MCID: TPT001
MIFTS: 51

Tauopathy malady

Summaries for Tauopathy

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A neurodegenerative disease that has material basis in the pathological aggregation of tau protein in so-called neurofibrillary tangles (nft) in the human brain.

MalaCards: Tauopathy, also known as tauopathies, is related to dementia and alzheimer's disease. An important gene associated with Tauopathy is MAPT (microtubule-associated protein tau), and among its related pathways are Parkinsons Disease Pathway and Alpha-synuclein signaling. The compounds thioflavine s and formate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are endocrine/exocrine gland and cellular.

Wikipedia:63 Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of... more...

Aliases & Classifications for Tauopathy

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

tauopathy 8
tauopathies 44 60


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Disease Ontology8 DOID:680
MeSH34 D024801

Related Diseases for Tauopathy

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17GeneCards, 18GeneDecks
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Diseases related to Tauopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.9RPS27A, GRN, HTT, NPC1, PSEN1, STH
2alzheimer's disease30.8NPEPPS, HTT, CAMK2G, RPS27A, GRN, SERPINI1
3frontotemporal dementia30.7PSEN1, MAPT
4progressive supranuclear palsy30.5RPS27A, MAPT, CDK5, LRRK2, PARK7, SNCA
5pick's disease30.3MAPT, PSEN1
6brain disease30.3MAPT, SNCA, SERPINI1, PSEN1
7motor neuron disease30.3INA, CDK5, MAPT, GRN, RPS27A, HTT
8lateral sclerosis30.3MAPT, SNCA
9amyotrophic lateral sclerosis30.3SNCA, PSEN1, GRN, MAPT, RPS27A, HTT
10parkinson's disease30.3PARK7, CAMK2G, RPS27A, HTT, PSEN1, STUB1
11aphasia30.1GRN, MAPT
12lewy body dementia30.1LRRK2, MAPT, SNCA
13transient cerebral ischemia30.1CAMK2G, RPS27A
14rem sleep behavior disorder30.0SNCA
15ischemia30.0SERPINI1, PSEN1, CAMK2G, SNCA, MAPK8, MAPT
16myositis29.8MAPT, SNCA, PSEN1, RPS27A
17multiple system atrophy29.8RPS27A, CDK5, LRRK2, MAPT, SNCA, HTT
18amyloidosis29.8RPS27A, MAPT, SNCA, PSEN1
19inclusion body myositis29.8MAPT, RPS27A
20movement disease29.8SNCA, LRRK2
21neuronitis10.7
22cerebritis10.2
23sleep disorder10.1
24tauopathy and respiratory failure10.1
25huntington's disease10.0HTT
26myopathy10.0RPS27A
27neuronal intranuclear inclusion disease10.0RPS27A
28apraxia10.0MAPT, GRN
29schizophrenia10.0NPEPPS, PSEN1, SNCA
30primary progressive aphasia10.0RPS27A, MAPT, GRN
31niemann-pick disease10.0MAPT, SNCA, NPC1
32brain ischemia10.0MAPT, CAMK2G
33parkinson disease type 310.0SNCA, LRRK2, MAPT, PARK7
34niemann–pick disease10.0NPC1
35semantic dementia10.0RPS27A, MAPT, GRN
36creutzfeldt-jakob syndrome10.0MAPT, RPS27A, SNCA
37vascular dementia10.0PSEN1, MAPT, RPS27A, SNCA
38spinocerebellar ataxia10.0MAPT, SNCA, RPS27A, HTT
39diabetes mellitus10.0MAPK8
40memory impairment10.0MAPT, GRN, SNCA, CDK5, PSEN1
41down syndrome10.0MAPT, PSEN1, SNCA
42frontotemporal lobar degeneration with ubiquitin-positive inclusions10.0GRN
43pancreatic cancer10.0MAPK8, RPS27A
44amyloid tumor10.0RPS27A, PSEN1, MAPT
45cerebral amyloid angiopathy10.0PSEN1, MAPT
46astrocytoma10.0MAPK8, SNCA, INA, PSEN1, CDKN3
47spinocerebellar ataxia type 310.0SNCA, HTT, RPS27A
48toxic encephalopathy10.0MAPT, MAPK8, HTT, CDK5
49essential tremor10.0SNCA, LRRK2
50glioblastoma multiforme10.0PPP2R4, MAPK8, GRN, CDKN3

Graphical network of the top 20 diseases related to Tauopathy:



Diseases related to tauopathy

Clinical Features for Tauopathy

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Drugs & Therapeutics for Tauopathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Tauopathy

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Genetic Tests for Tauopathy

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Anatomical Context for Tauopathy

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32MalaCards
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MalaCards organs/tissues related to Tauopathy:

32
Brain, Testes, Eye, Retina, Cortex

Animal Models for Tauopathy or affiliated genes

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36MGI
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Publications for Tauopathy

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50PubMed
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Articles related to Tauopathy:

(show top 50)    (show all 322)
idTitleAuthorsYear
1
Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. (24277722)
2014
2
Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice. (24362441)
2013
3
Non-invasive, in vivo monitoring of neuronal transport impairment in a mouse model of tauopathy using MEMRI. (22960250)
2013
4
Cerebrotendinous xanthomatosis with the c.379C>T (p.R127W) mutation in the CYP27A1 gene associated with premature age-associated limbic tauopathy. (23659550)
2013
5
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy. (23666556)
2013
6
In vivo functional brain mapping in a conditional mouse model of human tauopathy (tau(P301L)) reveals reduced neural activity in memory formation structures. (23379588)
2013
7
Mutations in MAPT give rise to aneuploidy in animal models of tauopathy. (24218087)
2013
8
Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy. (22874558)
2012
9
Anticholinergics boost the pathological process of neurodegeneration with increased inflammation in a tauopathy mouse model. (21889983)
2012
10
Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity. (22611162)
2012
11
Autosomal dominant tauopathy with parkinsonism and central hypoventilation. (22357714)
2012
12
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (21685912)
2011
13
Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease. (21812967)
2011
14
Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics. (22654720)
2011
15
Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies. (21442128)
2011
16
Corticobasal degeneration: a pathologically distinct 4R tauopathy. (21487420)
2011
17
Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy. (19427061)
2011
18
Acetylation of tau inhibits its degradation and contributes to tauopathy. (20869593)
2010
19
DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. (19606065)
2009
20
Tau exon 10 alternative splicing and tauopathies. (18616804)
2008
21
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. (18431510)
2008
22
A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics. (18490011)
2008
23
Tauopathy in human and experimental variant Creutzfeldt-Jakob disease. (17560687)
2008
24
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. (17113760)
2007
25
Cytosine beta-D-arabinofuranoside used as a paradigm modifier to increase production of tau aggregates in a cellular model of tauopathy. (17151917)
2007
26
Kinase activities increase during the development of tauopathy in htau mice. (17908241)
2007
27
N-phenylamine derivatives as aggregation inhibitors in cell models of tauopathy. (17908042)
2007
28
Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies. (17080726)
2006
29
Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. (16571759)
2006
30
Current strategies for the treatment of Alzheimer's disease and other tauopathies. (16981824)
2006
31
Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies. (15977985)
2005
32
Quantitative analysis of tau isoform transcripts in sporadic tauopathies. (15950767)
2005
33
Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies. (15645264)
2005
34
Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies. (15541003)
2004
35
Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice. (15658002)
2004
36
Neuropathology of tauopathies and synucleinopathies, and neuroanatomy of sleep disorders: meeting the challenge]. (14646802)
2003
37
Primary progressive aphasia as the initial manifestation of corticobasal degeneration and unusual tauopathies. (12955398)
2003
38
Dementia with Lewy bodies from the perspective of tauopathy. (12557014)
2003
39
Neurodegenerative tauopathy in the worm. (12913116)
2003
40
Ubiquitin-negative mini-pick-like bodies in the dentate gyrus in p301l tauopathy. (14757934)
2003
41
Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex--tauopathy without mutations in the tau gene? (12899197)
2003
42
Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. (12872001)
2003
43
Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam. (12093078)
2002
44
Neurofibrillary degeneration can be arrested in an in vivo cellular model of human tauopathy by application of a compound which inhibits tau filament formation in vitro. (12540050)
2002
45
Transgenic mouse models of tauopathies: prospects for animal models of Pick's disease. (11402147)
2001
46
New insights into genetic and molecular mechanisms of brain degeneration in tauopathies. (11207421)
2000
47
Molecular genetics of chromosome 17 tauopathies. (11193178)
2000
48
Tau gene mutation G389R causes a tauopathy with abundant pick body- like inclusions and axonal deposits. (10604746)
1999
49
A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy. (10412802)
1999
50
Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments. (9108114)
1997

Genetic Variations for Tauopathy

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Expression for genes affiliated with Tauopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tauopathy

Search GEO for disease gene expression data for Tauopathy.

Pathways for genes affiliated with Tauopathy

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37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 53Reactome, 4Cell Signaling Technology
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Pathways related to Tauopathy according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4PARK7, LRRK2, SNCA
210.4SNCA, STUB1, PARK7
310.4PSEN1, CDK5, MAPT
4
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10.4INA, CDK5, MAPT
510.3MAPK8, MAPT, CDK5
6
Hide members
10.3CDK5, MAPK8, CAMK2G, PSEN1
710.3CDK5, MAPT, MAPK8, PPP2R4
8
Hide members
10.3PPP2R4, MAPK8, MAPT, CDK5
910.3CDK5, MAPT, MAPK8, PPP2R4
10
Hide members
10.3MAPK8, MAPT, SNCA, STUB1, PPP2R4
11
Hide members
10.3STUB1, RPS27A, SNCA, MAPT, PARK7, MAPK8
1210.2PARK7, HTT, CAMK2G, PSEN1, MAPT, CDK5
13
Hide members
10.2HTT, PSEN1, MAPK8, MAPT, CDK5, SNCA

Compounds for genes affiliated with Tauopathy

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44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Tauopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1thioflavine s4410.8RPS27A, SNCA, MAPT
2formate4410.7MAPT, SNCA, RPS27A, HTT
34-hydroxynonenal44 2411.7MAPT, MAPK8, SNCA, PSEN1, RPS27A
4microcystin-lr4410.7CAMK2G, PPP2R4, CDKN3
5nmda44 2811.7MAPT, PPP2R4, HTT, PSEN1, CAMK2G, RPS27A
66-hydroxydopamine4410.7SNCA, RPS27A, CDK5, PARK7
7rotenone4410.7RPS27A, SNCA, MAPK8, PARK7
8lactacystin4410.7PSEN1, SNCA, MAPT, RPS27A, MAPK8, CDKN3
9kainate44 2811.7HTT, CDKN3, MAPT, PSEN1, CAMK2G
10levodopa44 1111.6CDK5, PARK7, RPS27A, CAMK2G, SNCA, CDKN3
11nocodazole44 1111.6CAMK2G, MAPT, CDKN3, PPP2R4, MAPK8
12calyculin a44 59 1112.6PPP2R4, MAPT, CAMK2G, CDKN3
13mg 13244 5911.6PPP2R4, RPS27A, SNCA, MAPK8, MAPT
14phosphoserine44 2411.6MAPT, PPP2R4, CAMK2G, CDKN3
15okadaic acid44 5911.6MAPK8, MAPT, CDKN3, CDK5, CAMK2G, PPP2R4
16n acetylcysteine4410.6MAPT, SNCA, MAPK8, PPP2R4, CDK5, RPS27A
17dopamine44 28 11 2413.6SNCA, RPS27A, CAMK2G, HTT, PPP2R4, CDK5
18proline4410.6RPS27A, CAMK2G, HTT, PSEN1, PPP2R4, CDK5
19geldanamycin44 49 59 1113.6HTT, STUB1, SNCA, RPS27A
20tacrolimus44 49 1112.6SNCA, PPP2R4, CAMK2G, RPS27A, CDKN3
21c2ceramide4410.6PPP2R4, MAPK8, MAPT, CDKN3
22testosterone44 59 11 2413.6CDKN3, PARK7, MAPT, SNCA, STUB1, PPP2R4
23glycogen44 2411.6HTT, RPS27A, PSEN1, SNCA, MAPT, CDKN3
24rapamycin4410.6HTT, MAPK8, CDKN3, PPP2R4, RPS27A, CAMK2G
25superoxide44 2411.5PARK7, CAMK2G, HTT, CDK5, MAPK8, PPP2R4
26thapsigargin44 5911.5MAPK8, PPP2R4, PSEN1, CAMK2G, CDKN3
27glutamine4410.5RPS27A, PSEN1, HTT, NPEPPS, PPP2R4, STUB1
28phosphothreonine4410.5PPP2R4, CDKN3, MAPT
29cycloheximide4410.5PARK7, MAPT, MAPK8, PPP2R4, PSEN1, CDKN3
30glutamate4410.5CDK5, HTT, PSEN1, PPP2R4, RPS27A, SNCA
31alanine4410.5CDKN3, CDK5, MAPT, SNCA, PPP2R4, RPS27A
32cysteine4410.5RPS27A, PSEN1, HTT, NPC1, PPP2R4, SNCA
33lysine4410.5PSEN1, HTT, PPP2R4, SNCA, PARK7, RPS27A
34h2o24410.5PARK7, MAPT, MAPK8, SNCA, CDK5, PPP2R4
35threonine4410.5PSEN1, CAMK2G, PPP2R4, CDKN3, CDK5, MAPK8
36butyrate4410.5HTT, MAPK8, MAPT, CDKN3, RPS27A
37oxygen44 2411.5PARK7, CAMK2G, HTT, PSEN1, PPP2R4, SNCA
38acetylcholine44 49 28 11 2414.5MAPT, RPS27A, CDKN3, CAMK2G, SNCA
39retinoic acid44 2411.5MAPT, INA, CDKN3, PPP2R4, MAPK8, CDK5
40cytochalasin d44 5911.5CDKN3, MAPK8, CAMK2G, MAPT
41glucose4410.4PSEN1, SNCA, MAPT, CAMK2G, HTT, GRN
42cap-p4410.4CDKN3, PPP2R4
43serine4410.4RPS27A, HTT, SERPINI1, CDK5, CDKN3, MAPT
44thioflavin4410.4MAPT, SNCA
45tyrosine4410.4PSEN1, HTT, RPS27A, CAMK2G, PARK7, PPP2R4
46lipid4410.4PPP2R4, PSEN1, HTT, CAMK2G, NPC1, SNCA
47chelerythrine4410.3CAMK2G, MAPK8, CDKN3
48atp44 2811.3CDK5, HTT, NPC1, PPP2R4, CAMK2G, RPS27A
49cytostatin4410.3PPP2R4, CDKN3
50cocaine44 1111.0CDK5, CDKN3, SNCA, CAMK2G

GO Terms for genes affiliated with Tauopathy

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16Gene Ontology
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Cellular components related to Tauopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inclusion bodyGO:01623410.4SNCA, HTT
2axonGO:03042410.3PSEN1, CDK5, MAPT, SNCA, HTT
3growth coneGO:03042610.2PSEN1, CDK5, MAPT, SNCA
4cytosolGO:0058299.8CDK5, STUB1, RPS27A, CAMK2G, HTT, NPEPPS

Biological processes related to Tauopathy according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1dopamine uptake involved in synaptic transmissionGO:05158310.7SNCA, PARK7
2regulation of locomotionGO:04001210.7SNCA, LRRK2
3negative regulation of neuron apoptotic processGO:04352410.7HTT, PSEN1, SNCA, PARK7
4regulation of synaptic plasticityGO:04816710.6CDK5, PSEN1, HTT
5neuron apoptotic processGO:05140210.6PSEN1, CDK5, HTT
6positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:03243610.6PSEN1, STUB1, LRRK2
7peptidyl-threonine phosphorylationGO:01810710.6LRRK2, MAPK8, CDK5
8positive regulation of receptor recyclingGO:00192110.6PSEN1, SNCA
9autophagyGO:00691410.6NPC1, LRRK2, PARK7
10axon cargo transportGO:00808810.6HTT, MAPT
11peptidyl-serine phosphorylationGO:01810510.6MAPK8, CDK5, LRRK2
12behavioral response to cocaineGO:04814810.5SNCA, CDK5
13determination of adult lifespanGO:00834010.5HTT, LRRK2
14positive regulation of apoptotic processGO:04306510.4PSEN1, RPS27A, PPP2R4, MAPK8
15synaptic vesicle endocytosisGO:04848810.4CDK5, SNCA
16protein polyubiquitinationGO:00020910.3STUB1, RPS27A, NPEPPS
17neuron migrationGO:00176410.3CDK5, MAPT, PSEN1
18axon extensionGO:04867510.1MAPT, CDK5

Molecular functions related to Tauopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Hsp70 protein bindingGO:03054410.4SNCA, STUB1
2protein bindingGO:0055159.6PARK7, CAMK2G, HTT, NPC1, PSEN1, STUB1

Products for genes affiliated with Tauopathy

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Sources for Tauopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet