MCID: TPT001
MIFTS: 35

Tauopathy malady

Neuronal diseases category

Summaries for Tauopathy

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A neurodegenerative disease that has material basis in the pathological aggregation of tau protein in so-called neurofibrillary tangles (nft) in the human brain.

MalaCards: Tauopathy, also known as tauopathies, is related to dementia and alzheimer's disease. An important gene associated with Tauopathy is MAPT (microtubule-associated protein tau), and among its related pathways are Reelin Pathway (Cajal-Retzius cells) and IL-6 Signaling Pathway. The compound roscovitine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes.

Wikipedia:66 Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of... more...

Aliases & Classifications for Tauopathy

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9Disease Ontology, 46Novoseek, 63UMLS, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

tauopathy 9
tauopathies 46 63


External Ids:

Disease Ontology9 DOID:680
MeSH36 D024801

Related Diseases for Tauopathy

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Tauopathy:



Diseases related to tauopathy

Symptoms for Tauopathy

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Drugs & Therapeutics for Tauopathy

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Tauopathy

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Genetic Tests for Tauopathy

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Anatomical Context for Tauopathy

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34MalaCards
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MalaCards organs/tissues related to Tauopathy:

34
Brain, Eye, Testes, Retina, Cortex

Animal Models for Tauopathy or affiliated genes

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Publications for Tauopathy

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53PubMed
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Articles related to Tauopathy:

(show top 50)    (show all 318)
idTitleAuthorsYear
1
Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. (24277722)
2014
2
Attenuation of I^-amyloid-induced tauopathy via activation of CK2I+/SIRT1: Targeting for cilostazol. (24254769)
2014
3
Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy. (23478312)
2013
4
Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells. (24319659)
2013
5
Neurodegenerative disease: can synucleinopathy and tauopathy be identified during life? (23857044)
2013
6
Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice. (24362441)
2013
7
MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. (22723018)
2012
8
Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy. (22874558)
2012
9
Anticholinergics boost the pathological process of neurodegeneration with increased inflammation in a tauopathy mouse model. (21889983)
2012
10
Potential neuroprotective strategies against tauopathy. (22817711)
2012
11
Impedance spectroscopy based measurement system for quantitative and label-free real-time monitoring of tauopathy in hippocampal slice cultures. (22221799)
2012
12
Loss of dopaminoreceptive neuron causes L-dopa resistant parkinsonism in tauopathy. (22169201)
2012
13
Is intractable epilepsy a tauopathy? (21440375)
2011
14
Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy. (21976528)
2011
15
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (21685912)
2011
16
Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity. (20882568)
2010
17
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. (20943926)
2010
18
Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies. (20569300)
2010
19
Generation of tau aggregates and clearance by autophagy in an inducible cell model of tauopathy. (20173337)
2010
20
Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. (20599975)
2010
21
A novel organotypic tauopathy model on a new microcavity chip for bioelectronic label-free and real time monitoring. (20591644)
2010
22
Development of a sensitive ELISA for quantification of three- and four-repeat tau isoforms in tauopathies. (19427527)
2009
23
Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration. (19717642)
2009
24
Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies. (19238406)
2009
25
Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. (19074615)
2009
26
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy. (19535996)
2009
27
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies. (18322396)
2008
28
Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. (18322384)
2008
29
Hyperphosphorylated tau is a cause of neuronal dysfunction in tauopathy. (18688086)
2008
30
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. (17113760)
2007
31
Cytosine beta-D-arabinofuranoside used as a paradigm modifier to increase production of tau aggregates in a cellular model of tauopathy. (17151917)
2007
32
Relation of hippocampal phospho-SAPK/JNK granules in Alzheimer's disease and tauopathies to granulovacuolar degeneration bodies. (17089132)
2007
33
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy. (17985339)
2007
34
Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis? (17318305)
2007
35
TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. (16461276)
2006
36
Neuropathology of familial tauopathy. (17080727)
2006
37
Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein. (17030663)
2006
38
Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). (16291936)
2005
39
Unique tauopathy in Fukuyama-type congenital muscular dystrophy. (16319722)
2005
40
Frequency of tau mutations in familial and sporadic frontotemporal dementia and other tauopathies. (15372253)
2004
41
Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies. (15541003)
2004
42
Neuropathology of tauopathies and synucleinopathies, and neuroanatomy of sleep disorders: meeting the challenge]. (14646802)
2003
43
Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies. (14572447)
2003
44
Hippocampal sclerosis dementia with tauopathy. (12946017)
2003
45
Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies. (11447312)
2001
46
Neurodegenerative tauopathies. (11520930)
2001
47
Analysis of tauopathies with transgenic mice. (11597522)
2001
48
The status of "Pick's Disease" and other tauopathies within the frontotemporal dementias. (11164281)
2001
49
The molecular genetics of the tauopathies. (10959034)
2000
50
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. (10595524)
1999

Variations for Tauopathy

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Expression for genes affiliated with Tauopathy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tauopathy

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Pathways for genes affiliated with Tauopathy

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51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 31KEGG, 13EMD Millipore, 61Thomson Reuters, 56Reactome, 55R&D Systems, 5Cell Signaling Technology
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Compounds for genes affiliated with Tauopathy

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46Novoseek
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Compounds related to Tauopathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1roscovitine469.5CDK5R1, MAPT

GO Terms for genes affiliated with Tauopathy

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17Gene Ontology
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Cellular components related to Tauopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.5CDK5R1, SNCB
2axonGO:0304249.2CDK5R1, MAPT
3growth coneGO:0304269.0CDK5R1, MAPT, SNCB

Biological processes related to Tauopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron migrationGO:0017649.5CDK5R1, MAPT

Products for genes affiliated with Tauopathy

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Sources for Tauopathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet