MCID: TPT001
MIFTS: 51

Tauopathy malady

Summaries for Tauopathy

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A neurodegenerative disease that has material basis in the pathological aggregation of tau protein in so-called neurofibrillary tangles (nft) in the human brain.

MalaCards: Tauopathy, also known as tauopathies, is related to dementia and alzheimer's disease. An important gene associated with Tauopathy is MAPT (microtubule-associated protein tau), and among its related pathways are Parkinsons Disease Pathway and Alpha-synuclein signaling. The compounds thioflavine s and formate have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related mouse phenotypes are endocrine/exocrine gland and cellular.

Wikipedia:63 Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of... more...

Aliases & Classifications for Tauopathy

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

tauopathy 8
tauopathies 44 60


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Disease Ontology8 DOID:680
MeSH34 D024801

Related Diseases for Tauopathy

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17GeneCards, 18GeneDecks
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Diseases related to Tauopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.9RPS27A, GRN, HTT, NPC1, PSEN1, STH
2alzheimer's disease30.8NPEPPS, HTT, CAMK2G, RPS27A, GRN, SERPINI1
3frontotemporal dementia30.7PSEN1, MAPT
4progressive supranuclear palsy30.5RPS27A, MAPT, CDK5, LRRK2, PARK7, SNCA
5pick's disease30.3MAPT, PSEN1
6brain disease30.3MAPT, SNCA, SERPINI1, PSEN1
7motor neuron disease30.3INA, CDK5, MAPT, GRN, RPS27A, HTT
8lateral sclerosis30.3MAPT, SNCA
9amyotrophic lateral sclerosis30.3SNCA, PSEN1, GRN, MAPT, RPS27A, HTT
10parkinson's disease30.3PARK7, CAMK2G, RPS27A, HTT, PSEN1, STUB1
11aphasia30.1GRN, MAPT
12lewy body dementia30.1LRRK2, MAPT, SNCA
13transient cerebral ischemia30.1CAMK2G, RPS27A
14rem sleep behavior disorder30.0SNCA
15ischemia30.0SERPINI1, PSEN1, CAMK2G, SNCA, MAPK8, MAPT
16myositis29.8MAPT, SNCA, PSEN1, RPS27A
17multiple system atrophy29.8RPS27A, CDK5, LRRK2, MAPT, SNCA, HTT
18amyloidosis29.8RPS27A, MAPT, SNCA, PSEN1
19inclusion body myositis29.8MAPT, RPS27A
20movement disease29.8SNCA, LRRK2
21neuronitis10.7
22cerebritis10.2
23sleep disorder10.1
24tauopathy and respiratory failure10.1
25huntington's disease10.0HTT
26myopathy10.0RPS27A
27neuronal intranuclear inclusion disease10.0RPS27A
28apraxia10.0MAPT, GRN
29schizophrenia10.0NPEPPS, PSEN1, SNCA
30primary progressive aphasia10.0RPS27A, MAPT, GRN
31niemann-pick disease10.0MAPT, SNCA, NPC1
32brain ischemia10.0MAPT, CAMK2G
33parkinson disease type 310.0SNCA, LRRK2, MAPT, PARK7
34niemann–pick disease10.0NPC1
35semantic dementia10.0RPS27A, MAPT, GRN
36creutzfeldt-jakob syndrome10.0MAPT, RPS27A, SNCA
37vascular dementia10.0PSEN1, MAPT, RPS27A, SNCA
38spinocerebellar ataxia10.0MAPT, SNCA, RPS27A, HTT
39diabetes mellitus10.0MAPK8
40memory impairment10.0MAPT, GRN, SNCA, CDK5, PSEN1
41down syndrome10.0MAPT, PSEN1, SNCA
42frontotemporal lobar degeneration with ubiquitin-positive inclusions10.0GRN
43pancreatic cancer10.0MAPK8, RPS27A
44amyloid tumor10.0RPS27A, PSEN1, MAPT
45cerebral amyloid angiopathy10.0PSEN1, MAPT
46astrocytoma10.0MAPK8, SNCA, INA, PSEN1, CDKN3
47spinocerebellar ataxia type 310.0SNCA, HTT, RPS27A
48toxic encephalopathy10.0MAPT, MAPK8, HTT, CDK5
49essential tremor10.0SNCA, LRRK2
50glioblastoma multiforme10.0PPP2R4, MAPK8, GRN, CDKN3

Graphical network of the top 20 diseases related to Tauopathy:



Diseases related to tauopathy

Clinical Features for Tauopathy

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Drugs & Therapeutics for Tauopathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Tauopathy

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Genetic Tests for Tauopathy

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Anatomical Context for Tauopathy

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32MalaCards
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MalaCards organs/tissues related to Tauopathy:

32
Brain, Eye, Cortex, Retina, Testes

Animal Models for Tauopathy or affiliated genes

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36MGI
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Publications for Tauopathy

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50PubMed
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Articles related to Tauopathy:

(show top 50)    (show all 322)
idTitleAuthorsYear
1
Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy. (23478312)
2013
2
A Case of Globular Glial Tauopathy Presenting Clinically as Alzheimer Disease. (23751368)
2013
3
Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation. (23371364)
2013
4
Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy. (23977276)
2013
5
Can tauopathy shake the amyloid cascade hypothesis? (23670106)
2013
6
Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes. (21981382)
2012
7
Development and assessment of sensitive immuno-PCR assays for the quantification of cerebrospinal fluid three- and four-repeat tau isoforms in tauopathies. (22862741)
2012
8
Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model. (22315694)
2012
9
GSPE interferes with tau aggregation in vivo: implication for treating tauopathy. (22054871)
2012
10
Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy. (22426397)
2012
11
Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy. (22689910)
2012
12
CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. (22027994)
2012
13
Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. (22366796)
2012
14
Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. (22057275)
2012
15
Is intractable epilepsy a tauopathy? (21440375)
2011
16
Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. (21854751)
2011
17
Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy. (21312224)
2011
18
RaphAc tauopathy alters serotonin metabolism and breathing activity in terminal Tau.P301L mice: possible implications for tauopathies and Alzheimer's disease. (21763469)
2011
19
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. (21949350)
2011
20
Four-repeat tauopathy clinically presenting as posterior cortical atrophy: atypical corticobasal degeneration? (20571819)
2011
21
Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies. (20569300)
2010
22
The role of MSUT-2 in tau neurotoxicity: a target for neuroprotection in tauopathy? (20658987)
2010
23
High education may offer protection against tauopathy in patients with mild cognitive impairment. (20413900)
2010
24
Anti-inflammatory action of donepezil ameliorates tau pathology, synaptic loss, and neurodegeneration in a tauopathy mouse model. (20847440)
2010
25
Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies. (19238406)
2009
26
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy. (19535996)
2009
27
Concentration-dependent effects of proteasomal inhibition on tau processing in a cellular model of tauopathy. (19636403)
2009
28
A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. (19363289)
2009
29
Small-molecule mediated neuroprotection in an in situ model of tauopathy. (19384600)
2009
30
Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. (19535999)
2009
31
Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice. (18258852)
2008
32
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy. (17985339)
2007
33
The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model. (17715352)
2007
34
The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. (17716969)
2007
35
TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. (16461276)
2006
36
Neuropathology of familial tauopathy. (17080727)
2006
37
A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. (16950154)
2006
38
Modeling tauopathy: a range of complementary approaches. (15615641)
2005
39
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum. (15174015)
2004
40
The role of tau (MAPT) in frontotemporal dementia and related tauopathies. (15365985)
2004
41
Diffuse form of argyrophilic grain disease: a new variant of four-repeat tauopathy different from limbic argyrophilic grain disease. (14517683)
2003
42
Sporadic Pick's disease: a tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter. (12112079)
2002
43
A novel tau mutation, S320F, causes a tauopathy with inclusions similar to those in Pick's disease. (11891833)
2002
44
Analysis of tauopathies with transgenic mice. (11597522)
2001
45
The status of "Pick's Disease" and other tauopathies within the frontotemporal dementias. (11164281)
2001
46
Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. (11810404)
2001
47
Frontal lobe dementia with novel tauopathy: sporadic multiple system tauopathy with dementia. (11305868)
2001
48
The molecular genetics of the tauopathies. (10959034)
2000
49
Tau gene mutation K257T causes a tauopathy similar to Pick's disease. (11089577)
2000
50
Progress in hereditary tauopathies: a mutation in the Tau gene (G389R) causes a Pick disease-like syndrome. (11193177)
2000

Genetic Variations for Tauopathy

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Expression for genes affiliated with Tauopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tauopathy

Search GEO for disease gene expression data for Tauopathy.

Pathways for genes affiliated with Tauopathy

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37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 53Reactome, 4Cell Signaling Technology
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Pathways related to Tauopathy according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4SNCA, LRRK2, PARK7
210.4PARK7, SNCA, STUB1
310.4CDK5, MAPT, PSEN1
4
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10.4INA, CDK5, MAPT
510.3CDK5, MAPT, MAPK8
6
Hide members
10.3CDK5, MAPK8, PSEN1, CAMK2G
710.3CDK5, MAPT, MAPK8, PPP2R4
8
Hide members
10.3PPP2R4, MAPK8, MAPT, CDK5
910.3PPP2R4, MAPK8, MAPT, CDK5
10
Hide members
10.3PPP2R4, STUB1, SNCA, MAPK8, MAPT
11
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10.3RPS27A, STUB1, SNCA, MAPK8, MAPT, PARK7
1210.2PARK7, CAMK2G, HTT, PSEN1, SNCA, MAPT
13
Hide members
10.2HTT, PSEN1, SNCA, MAPK8, MAPT, CDK5

Compounds for genes affiliated with Tauopathy

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44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Tauopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1thioflavine s4410.8RPS27A, SNCA, MAPT
2formate4410.7MAPT, SNCA, RPS27A, HTT
34-hydroxynonenal44 2411.7MAPT, MAPK8, SNCA, PSEN1, RPS27A
4microcystin-lr4410.7CAMK2G, PPP2R4, CDKN3
5nmda44 2811.7MAPT, PPP2R4, HTT, PSEN1, CAMK2G, RPS27A
66-hydroxydopamine4410.7SNCA, RPS27A, CDK5, PARK7
7rotenone4410.7RPS27A, SNCA, MAPK8, PARK7
8lactacystin4410.7PSEN1, SNCA, MAPT, RPS27A, MAPK8, CDKN3
9kainate44 2811.7HTT, CDKN3, MAPT, PSEN1, CAMK2G
10levodopa44 1111.6CDK5, PARK7, RPS27A, CAMK2G, SNCA, CDKN3
11nocodazole44 1111.6CAMK2G, MAPT, CDKN3, PPP2R4, MAPK8
12calyculin a44 59 1112.6PPP2R4, MAPT, CAMK2G, CDKN3
13mg 13244 5911.6PPP2R4, RPS27A, SNCA, MAPK8, MAPT
14phosphoserine44 2411.6MAPT, PPP2R4, CAMK2G, CDKN3
15okadaic acid44 5911.6MAPK8, MAPT, CDKN3, CDK5, CAMK2G, PPP2R4
16n acetylcysteine4410.6MAPT, SNCA, MAPK8, PPP2R4, CDK5, RPS27A
17dopamine44 28 11 2413.6SNCA, RPS27A, CAMK2G, HTT, PPP2R4, CDK5
18proline4410.6RPS27A, CAMK2G, HTT, PSEN1, PPP2R4, CDK5
19geldanamycin44 49 59 1113.6HTT, STUB1, SNCA, RPS27A
20tacrolimus44 49 1112.6SNCA, PPP2R4, CAMK2G, RPS27A, CDKN3
21c2ceramide4410.6PPP2R4, MAPK8, MAPT, CDKN3
22testosterone44 59 11 2413.6CDKN3, PARK7, MAPT, SNCA, STUB1, PPP2R4
23glycogen44 2411.6HTT, RPS27A, PSEN1, SNCA, MAPT, CDKN3
24rapamycin4410.6HTT, MAPK8, CDKN3, PPP2R4, RPS27A, CAMK2G
25superoxide44 2411.5PARK7, CAMK2G, HTT, CDK5, MAPK8, PPP2R4
26thapsigargin44 5911.5MAPK8, PPP2R4, PSEN1, CAMK2G, CDKN3
27glutamine4410.5RPS27A, PSEN1, HTT, NPEPPS, PPP2R4, STUB1
28phosphothreonine4410.5PPP2R4, CDKN3, MAPT
29cycloheximide4410.5PARK7, MAPT, MAPK8, PPP2R4, PSEN1, CDKN3
30glutamate4410.5CDK5, HTT, PSEN1, PPP2R4, RPS27A, SNCA
31alanine4410.5CDKN3, CDK5, MAPT, SNCA, PPP2R4, RPS27A
32cysteine4410.5RPS27A, PSEN1, HTT, NPC1, PPP2R4, SNCA
33lysine4410.5PSEN1, HTT, PPP2R4, SNCA, PARK7, RPS27A
34h2o24410.5PARK7, MAPT, MAPK8, SNCA, CDK5, PPP2R4
35threonine4410.5PSEN1, CAMK2G, PPP2R4, CDKN3, CDK5, MAPK8
36butyrate4410.5HTT, MAPK8, MAPT, CDKN3, RPS27A
37oxygen44 2411.5PARK7, CAMK2G, HTT, PSEN1, PPP2R4, SNCA
38acetylcholine44 49 28 11 2414.5MAPT, RPS27A, CDKN3, CAMK2G, SNCA
39retinoic acid44 2411.5MAPT, INA, CDKN3, PPP2R4, MAPK8, CDK5
40cytochalasin d44 5911.5CDKN3, MAPK8, CAMK2G, MAPT
41glucose4410.4PSEN1, SNCA, MAPT, CAMK2G, HTT, GRN
42cap-p4410.4CDKN3, PPP2R4
43serine4410.4RPS27A, HTT, SERPINI1, CDK5, CDKN3, MAPT
44thioflavin4410.4MAPT, SNCA
45tyrosine4410.4PSEN1, HTT, RPS27A, CAMK2G, PARK7, PPP2R4
46lipid4410.4PPP2R4, PSEN1, HTT, CAMK2G, NPC1, SNCA
47chelerythrine4410.3CAMK2G, MAPK8, CDKN3
48atp44 2811.3CDK5, HTT, NPC1, PPP2R4, CAMK2G, RPS27A
49cytostatin4410.3PPP2R4, CDKN3
50cocaine44 1111.0CDK5, CDKN3, SNCA, CAMK2G

GO Terms for genes affiliated with Tauopathy

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16Gene Ontology
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Cellular components related to Tauopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inclusion bodyGO:01623410.4SNCA, HTT
2axonGO:03042410.3CDK5, MAPT, SNCA, PSEN1, HTT
3growth coneGO:03042610.2PSEN1, SNCA, MAPT, CDK5
4cytosolGO:0058299.8RPS27A, CAMK2G, HTT, NPEPPS, STUB1, SNCA

Biological processes related to Tauopathy according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1dopamine uptake involved in synaptic transmissionGO:05158310.7PARK7, SNCA
2regulation of locomotionGO:04001210.7SNCA, LRRK2
3negative regulation of neuron apoptotic processGO:04352410.7PARK7, SNCA, PSEN1, HTT
4neuron apoptotic processGO:05140210.6HTT, PSEN1, CDK5
5regulation of synaptic plasticityGO:04816710.6HTT, PSEN1, CDK5
6positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:03243610.6LRRK2, STUB1, PSEN1
7peptidyl-threonine phosphorylationGO:01810710.6MAPK8, CDK5, LRRK2
8positive regulation of receptor recyclingGO:00192110.6SNCA, PSEN1
9autophagyGO:00691410.6NPC1, LRRK2, PARK7
10axon cargo transportGO:00808810.6MAPT, HTT
11peptidyl-serine phosphorylationGO:01810510.6LRRK2, CDK5, MAPK8
12behavioral response to cocaineGO:04814810.5CDK5, SNCA
13determination of adult lifespanGO:00834010.5HTT, LRRK2
14positive regulation of apoptotic processGO:04306510.4RPS27A, PSEN1, PPP2R4, MAPK8
15synaptic vesicle endocytosisGO:04848810.4CDK5, SNCA
16protein polyubiquitinationGO:00020910.3STUB1, NPEPPS, RPS27A
17neuron migrationGO:00176410.3PSEN1, MAPT, CDK5
18axon extensionGO:04867510.1CDK5, MAPT

Molecular functions related to Tauopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Hsp70 protein bindingGO:03054410.4SNCA, STUB1
2protein bindingGO:0055159.6PARK7, CAMK2G, HTT, NPC1, PSEN1, STUB1

Products for genes affiliated with Tauopathy

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Sources for Tauopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet