MCID: TPT001
MIFTS: 35

Tauopathy malady

Neuronal diseases category
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Summaries for Tauopathy

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Disease Ontology:8 A neurodegenerative disease that has material basis in the pathological aggregation of tau protein in so-called neurofibrillary tangles (nft) in the human brain.

MalaCards based summary: Tauopathy, also known as tauopathies, is related to progressive supranuclear palsy and dementia. An important gene associated with Tauopathy is MAPT (microtubule-associated protein tau), and among its related pathways are Reelin Pathway (Cajal-Retzius cells) and IL-6 Signaling Pathway. The compound roscovitine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex.

Wikipedia:65 Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of... more...

Aliases & Classifications for Tauopathy

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 34MeSH
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Tauopathy, Aliases & Descriptions:

Name: Tauopathy 8
 
Tauopathies 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:680
MeSH34 D024801

Related Diseases for Tauopathy

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Graphical network of the top 20 diseases related to Tauopathy:



Diseases related to tauopathy

Symptoms for Tauopathy

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Drugs & Therapeutics for Tauopathy

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Drug clinical trials:

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Search NIH Clinical Center for Tauopathy

Genetic Tests for Tauopathy

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Anatomical Context for Tauopathy

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MalaCards organs/tissues related to Tauopathy:

32
Brain, Eye, Cortex, Retina, Testes

Animal Models for Tauopathy or affiliated genes

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Publications for Tauopathy

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Articles related to Tauopathy:

(show top 50)    (show all 335)
idTitleAuthorsYear
1
Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. (24277722)
2014
2
Attenuation of I^-amyloid-induced tauopathy via activation of CK2I+/SIRT1: Targeting for cilostazol. (24254769)
2014
3
Cyclin-dependent kinase 5, a node protein in diminished tauopathy: a systems biology approach. (25225483)
2014
4
Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy. (23478312)
2013
5
Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells. (24319659)
2013
6
Neurodegenerative disease: can synucleinopathy and tauopathy be identified during life? (23857044)
2013
7
Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice. (24362441)
2013
8
MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. (22723018)
2012
9
Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy. (22874558)
2012
10
Anticholinergics boost the pathological process of neurodegeneration with increased inflammation in a tauopathy mouse model. (21889983)
2012
11
Potential neuroprotective strategies against tauopathy. (22817711)
2012
12
Impedance spectroscopy based measurement system for quantitative and label-free real-time monitoring of tauopathy in hippocampal slice cultures. (22221799)
2012
13
Loss of dopaminoreceptive neuron causes L-dopa resistant parkinsonism in tauopathy. (22169201)
2012
14
Is intractable epilepsy a tauopathy? (21440375)
2011
15
Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy. (21976528)
2011
16
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (21685912)
2011
17
Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity. (20882568)
2010
18
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. (20943926)
2010
19
Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies. (20569300)
2010
20
Generation of tau aggregates and clearance by autophagy in an inducible cell model of tauopathy. (20173337)
2010
21
Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. (20599975)
2010
22
A novel organotypic tauopathy model on a new microcavity chip for bioelectronic label-free and real time monitoring. (20591644)
2010
23
Development of a sensitive ELISA for quantification of three- and four-repeat tau isoforms in tauopathies. (19427527)
2009
24
Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration. (19717642)
2009
25
Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies. (19238406)
2009
26
Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. (19074615)
2009
27
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy. (19535996)
2009
28
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies. (18322396)
2008
29
Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. (18322384)
2008
30
Hyperphosphorylated tau is a cause of neuronal dysfunction in tauopathy. (18688086)
2008
31
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. (17113760)
2007
32
Cytosine beta-D-arabinofuranoside used as a paradigm modifier to increase production of tau aggregates in a cellular model of tauopathy. (17151917)
2007
33
Relation of hippocampal phospho-SAPK/JNK granules in Alzheimer's disease and tauopathies to granulovacuolar degeneration bodies. (17089132)
2007
34
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy. (17985339)
2007
35
Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis? (17318305)
2007
36
TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. (16461276)
2006
37
Neuropathology of familial tauopathy. (17080727)
2006
38
Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein. (17030663)
2006
39
Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). (16291936)
2005
40
Unique tauopathy in Fukuyama-type congenital muscular dystrophy. (16319722)
2005
41
Frequency of tau mutations in familial and sporadic frontotemporal dementia and other tauopathies. (15372253)
2004
42
Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies. (15541003)
2004
43
Neuropathology of tauopathies and synucleinopathies, and neuroanatomy of sleep disorders: meeting the challenge]. (14646802)
2003
44
Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies. (14572447)
2003
45
Hippocampal sclerosis dementia with tauopathy. (12946017)
2003
46
Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies. (11447312)
2001
47
Analysis of tauopathies with transgenic mice. (11597522)
2001
48
The status of "Pick's Disease" and other tauopathies within the frontotemporal dementias. (11164281)
2001
49
The molecular genetics of the tauopathies. (10959034)
2000
50
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. (10595524)
1999

Variations for Tauopathy

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Expression for genes affiliated with Tauopathy

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Expression patterns in normal tissues for genes affiliated with Tauopathy

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Pathways for genes affiliated with Tauopathy

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Compounds for genes affiliated with Tauopathy

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Sources:
44Novoseek
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Compounds related to Tauopathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1roscovitine449.5CDK5R1, MAPT

GO Terms for genes affiliated with Tauopathy

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Cellular components related to Tauopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.5CDK5R1, SNCB
2axonGO:0304249.2CDK5R1, MAPT
3growth coneGO:0304269.0CDK5R1, MAPT, SNCB

Biological processes related to Tauopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron migrationGO:0017649.5CDK5R1, MAPT

Products for genes affiliated with Tauopathy

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Sources for Tauopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet