MCID: TPT001
MIFTS: 51

Tauopathy malady

Summaries for Tauopathy

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A neurodegenerative disease that has material basis in the pathological aggregation of tau protein in so-called neurofibrillary tangles (nft) in the human brain.

MalaCards: Tauopathy, also known as tauopathies, is related to dementia and alzheimer's disease. An important gene associated with Tauopathy is MAPT (microtubule-associated protein tau), and among its related pathways are Parkinsons Disease Pathway and Alpha-synuclein signaling. The compounds thioflavine s and formate have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related mouse phenotypes are endocrine/exocrine gland and cellular.

Wikipedia:63 Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of... more...

Aliases & Classifications for Tauopathy

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

tauopathy 8
tauopathies 44 60


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Disease Ontology8 DOID:680
MeSH34 D024801

Related Diseases for Tauopathy

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17GeneCards, 18GeneDecks
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Diseases related to Tauopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.9RPS27A, GRN, HTT, NPC1, PSEN1, STH
2alzheimer's disease30.8NPEPPS, HTT, CAMK2G, RPS27A, GRN, SERPINI1
3frontotemporal dementia30.7PSEN1, MAPT
4progressive supranuclear palsy30.5RPS27A, MAPT, CDK5, LRRK2, PARK7, SNCA
5pick's disease30.3MAPT, PSEN1
6brain disease30.3MAPT, SNCA, SERPINI1, PSEN1
7motor neuron disease30.3INA, CDK5, MAPT, GRN, RPS27A, HTT
8lateral sclerosis30.3MAPT, SNCA
9amyotrophic lateral sclerosis30.3SNCA, PSEN1, GRN, MAPT, RPS27A, HTT
10parkinson's disease30.3PARK7, CAMK2G, RPS27A, HTT, PSEN1, STUB1
11aphasia30.1GRN, MAPT
12lewy body dementia30.1LRRK2, MAPT, SNCA
13transient cerebral ischemia30.1CAMK2G, RPS27A
14rem sleep behavior disorder30.0SNCA
15ischemia30.0SERPINI1, PSEN1, CAMK2G, SNCA, MAPK8, MAPT
16myositis29.8MAPT, SNCA, PSEN1, RPS27A
17multiple system atrophy29.8RPS27A, CDK5, LRRK2, MAPT, SNCA, HTT
18amyloidosis29.8RPS27A, MAPT, SNCA, PSEN1
19inclusion body myositis29.8MAPT, RPS27A
20movement disease29.8SNCA, LRRK2
21neuronitis10.7
22cerebritis10.2
23sleep disorder10.1
24tauopathy and respiratory failure10.1
25huntington's disease10.0HTT
26myopathy10.0RPS27A
27neuronal intranuclear inclusion disease10.0RPS27A
28apraxia10.0MAPT, GRN
29schizophrenia10.0NPEPPS, PSEN1, SNCA
30primary progressive aphasia10.0RPS27A, MAPT, GRN
31niemann-pick disease10.0MAPT, SNCA, NPC1
32brain ischemia10.0MAPT, CAMK2G
33parkinson disease type 310.0SNCA, LRRK2, MAPT, PARK7
34niemann–pick disease10.0NPC1
35semantic dementia10.0RPS27A, MAPT, GRN
36creutzfeldt-jakob syndrome10.0MAPT, RPS27A, SNCA
37vascular dementia10.0PSEN1, MAPT, RPS27A, SNCA
38spinocerebellar ataxia10.0MAPT, SNCA, RPS27A, HTT
39diabetes mellitus10.0MAPK8
40memory impairment10.0MAPT, GRN, SNCA, CDK5, PSEN1
41down syndrome10.0MAPT, PSEN1, SNCA
42frontotemporal lobar degeneration with ubiquitin-positive inclusions10.0GRN
43pancreatic cancer10.0MAPK8, RPS27A
44amyloid tumor10.0RPS27A, PSEN1, MAPT
45cerebral amyloid angiopathy10.0PSEN1, MAPT
46astrocytoma10.0MAPK8, SNCA, INA, PSEN1, CDKN3
47spinocerebellar ataxia type 310.0SNCA, HTT, RPS27A
48toxic encephalopathy10.0MAPT, MAPK8, HTT, CDK5
49essential tremor10.0SNCA, LRRK2
50glioblastoma multiforme10.0PPP2R4, MAPK8, GRN, CDKN3

Graphical network of the top 20 diseases related to Tauopathy:



Diseases related to tauopathy

Clinical Features for Tauopathy

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Drugs & Therapeutics for Tauopathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Tauopathy

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Genetic Tests for Tauopathy

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Anatomical Context for Tauopathy

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32MalaCards
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MalaCards organs/tissues related to Tauopathy:

32
Brain, Eye, Cortex, Retina, Testes

Animal Models for Tauopathy or affiliated genes

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36MGI
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Publications for Tauopathy

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50PubMed
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Articles related to Tauopathy:

(show top 50)    (show all 322)
idTitleAuthorsYear
1
Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare. (23704923)
2013
2
Preparation and Characterization of Methylene blue Nanoparticles for Alzheimer's disease and other Tauopathies. (24237400)
2013
3
Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. (23325240)
2013
4
Atypical association of semantic dementia, corticobasal syndrome, and 4R tauopathy. (24156410)
2013
5
Impedance spectroscopy based measurement system for quantitative and label-free real-time monitoring of tauopathy in hippocampal slice cultures. (22221799)
2012
6
Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies. (22009441)
2012
7
Review: tauopathy in the retina and optic nerve: does it shadow pathological changes in the brain? (23170062)
2012
8
A neuroprotective role for the DNA damage checkpoint in tauopathy. (22181010)
2012
9
The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features. (22595371)
2012
10
P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. (21698260)
2011
11
Unclassifiable tauopathy associated with an A152T variation in MAPT exon 7. (21176711)
2011
12
Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice. (21324362)
2011
13
Zebrafish models of Tauopathy. (20849952)
2011
14
Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity. (20882568)
2010
15
Grape-seed polyphenolic extract improves the eye phenotype in a Drosophila model of tauopathy. (20871666)
2010
16
CSF phospho-tau correlates with behavioural decline and brain insoluble phospho-tau levels in a rat model of tauopathy. (20379729)
2010
17
Alzheimer's disease and tauopathy studies in flies and worms. (20302939)
2010
18
Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. (21123557)
2010
19
An okadaic acid-induced model of tauopathy and cognitive deficiency. (20807517)
2010
20
Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, Parkinsonism, and motor neuron disease: a distinct clinicopathological and biochemical disease entity. (20140439)
2010
21
Development of a sensitive ELISA for quantification of three- and four-repeat tau isoforms in tauopathies. (19427527)
2009
22
Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration. (19717642)
2009
23
Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. (19074615)
2009
24
Hippocampal sclerosis with four-repeat tau-positive round inclusions in the dentate gyrus: a new type of four-repeat tauopathy. (19360425)
2009
25
The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family. (18065436)
2008
26
Atypical tauopathy with massive involvement of the white matter. (18208485)
2008
27
Relation of hippocampal phospho-SAPK/JNK granules in Alzheimer's disease and tauopathies to granulovacuolar degeneration bodies. (17089132)
2007
28
Inhibition of tau aggregation in cell models of tauopathy. (18220518)
2007
29
Tau aggregation and toxicity in a cell culture model of tauopathy. (17428800)
2007
30
Accumulation of pathological tau species and memory loss in a conditional model of tauopathy. (17409229)
2007
31
Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein. (17030663)
2006
32
Ultrastructural characteristics of tau filaments in tauopathies: immuno-electron microscopic demonstration of tau filaments in tauopathies. (17080728)
2006
33
Animal models of tauopathies]. (17432223)
2006
34
Abnormal Sp1 transcription factor expression in Alzheimer disease and tauopathies. (16378688)
2006
35
Unique tauopathy in Fukuyama-type congenital muscular dystrophy. (16319722)
2005
36
Exclusive induction of tau2 epitope in microglia/macrophages in inflammatory lesions-tautwopathy distinct from degenerative tauopathies. (15549333)
2005
37
Neurodegeneration in heterozygous Niemann-Pick type C1 (NPC1) mouse: implication of heterozygous NPC1 mutations being a risk for tauopathy. (15919659)
2005
38
Staging disease severity in movement disorder tauopathies: brain atrophy separates progressive supranuclear palsy from corticobasal degeneration. (15390131)
2005
39
Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model. (16238489)
2005
40
Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies. (15050686)
2004
41
Effects of alpha-tocopherol on an animal model of tauopathies. (15203189)
2004
42
Posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animals. (15270197)
2004
43
The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy. (12883828)
2003
44
Genetic modifiers of tauopathy in Drosophila. (14668378)
2003
45
Argyrophilic grain disease: molecular genetic difference to other four-repeat tauopathies. (14513264)
2003
46
Neurodegenerative tauopathies. (11520930)
2001
47
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. (11408621)
2001
48
The microtubule-associated protein tau in neurodegenerative diseases. Tauopathies]. (11562878)
2001
49
Tauopathies--a new class of neurodegenerative diseases]. (11256158)
2001
50
Dynamic neuropathology of tauopathy]. (12235808)
2001

Genetic Variations for Tauopathy

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Expression for genes affiliated with Tauopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tauopathy

Search GEO for disease gene expression data for Tauopathy.

Pathways for genes affiliated with Tauopathy

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37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 53Reactome, 4Cell Signaling Technology
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Pathways related to Tauopathy according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4SNCA, LRRK2, PARK7
210.4PARK7, SNCA, STUB1
310.4CDK5, MAPT, PSEN1
4
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10.4INA, CDK5, MAPT
510.3CDK5, MAPT, MAPK8
6
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10.3CDK5, MAPK8, PSEN1, CAMK2G
710.3CDK5, MAPT, MAPK8, PPP2R4
8
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10.3PPP2R4, MAPK8, MAPT, CDK5
910.3PPP2R4, MAPK8, MAPT, CDK5
10
Hide members
10.3PPP2R4, STUB1, SNCA, MAPK8, MAPT
11
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10.3RPS27A, STUB1, SNCA, MAPK8, MAPT, PARK7
1210.2PARK7, CAMK2G, HTT, PSEN1, SNCA, MAPT
13
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10.2HTT, PSEN1, SNCA, MAPK8, MAPT, CDK5

Compounds for genes affiliated with Tauopathy

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44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Tauopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1thioflavine s4410.8RPS27A, SNCA, MAPT
2formate4410.7MAPT, SNCA, RPS27A, HTT
34-hydroxynonenal44 2411.7MAPT, MAPK8, SNCA, PSEN1, RPS27A
4microcystin-lr4410.7CAMK2G, PPP2R4, CDKN3
5nmda44 2811.7MAPT, PPP2R4, HTT, PSEN1, CAMK2G, RPS27A
66-hydroxydopamine4410.7SNCA, RPS27A, CDK5, PARK7
7rotenone4410.7RPS27A, SNCA, MAPK8, PARK7
8lactacystin4410.7PSEN1, SNCA, MAPT, RPS27A, MAPK8, CDKN3
9kainate44 2811.7HTT, CDKN3, MAPT, PSEN1, CAMK2G
10levodopa44 1111.6CDK5, PARK7, RPS27A, CAMK2G, SNCA, CDKN3
11nocodazole44 1111.6CAMK2G, MAPT, CDKN3, PPP2R4, MAPK8
12calyculin a44 59 1112.6PPP2R4, MAPT, CAMK2G, CDKN3
13mg 13244 5911.6PPP2R4, RPS27A, SNCA, MAPK8, MAPT
14phosphoserine44 2411.6MAPT, PPP2R4, CAMK2G, CDKN3
15okadaic acid44 5911.6MAPK8, MAPT, CDKN3, CDK5, CAMK2G, PPP2R4
16n acetylcysteine4410.6MAPT, SNCA, MAPK8, PPP2R4, CDK5, RPS27A
17dopamine44 28 11 2413.6SNCA, RPS27A, CAMK2G, HTT, PPP2R4, CDK5
18proline4410.6RPS27A, CAMK2G, HTT, PSEN1, PPP2R4, CDK5
19geldanamycin44 49 59 1113.6HTT, STUB1, SNCA, RPS27A
20tacrolimus44 49 1112.6SNCA, PPP2R4, CAMK2G, RPS27A, CDKN3
21c2ceramide4410.6PPP2R4, MAPK8, MAPT, CDKN3
22testosterone44 59 11 2413.6CDKN3, PARK7, MAPT, SNCA, STUB1, PPP2R4
23glycogen44 2411.6HTT, RPS27A, PSEN1, SNCA, MAPT, CDKN3
24rapamycin4410.6HTT, MAPK8, CDKN3, PPP2R4, RPS27A, CAMK2G
25superoxide44 2411.5PARK7, CAMK2G, HTT, CDK5, MAPK8, PPP2R4
26thapsigargin44 5911.5MAPK8, PPP2R4, PSEN1, CAMK2G, CDKN3
27glutamine4410.5RPS27A, PSEN1, HTT, NPEPPS, PPP2R4, STUB1
28phosphothreonine4410.5PPP2R4, CDKN3, MAPT
29cycloheximide4410.5PARK7, MAPT, MAPK8, PPP2R4, PSEN1, CDKN3
30glutamate4410.5CDK5, HTT, PSEN1, PPP2R4, RPS27A, SNCA
31alanine4410.5CDKN3, CDK5, MAPT, SNCA, PPP2R4, RPS27A
32cysteine4410.5RPS27A, PSEN1, HTT, NPC1, PPP2R4, SNCA
33lysine4410.5PSEN1, HTT, PPP2R4, SNCA, PARK7, RPS27A
34h2o24410.5PARK7, MAPT, MAPK8, SNCA, CDK5, PPP2R4
35threonine4410.5PSEN1, CAMK2G, PPP2R4, CDKN3, CDK5, MAPK8
36butyrate4410.5HTT, MAPK8, MAPT, CDKN3, RPS27A
37oxygen44 2411.5PARK7, CAMK2G, HTT, PSEN1, PPP2R4, SNCA
38acetylcholine44 49 28 11 2414.5MAPT, RPS27A, CDKN3, CAMK2G, SNCA
39retinoic acid44 2411.5MAPT, INA, CDKN3, PPP2R4, MAPK8, CDK5
40cytochalasin d44 5911.5CDKN3, MAPK8, CAMK2G, MAPT
41glucose4410.4PSEN1, SNCA, MAPT, CAMK2G, HTT, GRN
42cap-p4410.4CDKN3, PPP2R4
43serine4410.4RPS27A, HTT, SERPINI1, CDK5, CDKN3, MAPT
44thioflavin4410.4MAPT, SNCA
45tyrosine4410.4PSEN1, HTT, RPS27A, CAMK2G, PARK7, PPP2R4
46lipid4410.4PPP2R4, PSEN1, HTT, CAMK2G, NPC1, SNCA
47chelerythrine4410.3CAMK2G, MAPK8, CDKN3
48atp44 2811.3CDK5, HTT, NPC1, PPP2R4, CAMK2G, RPS27A
49cytostatin4410.3PPP2R4, CDKN3
50cocaine44 1111.0CDK5, CDKN3, SNCA, CAMK2G

GO Terms for genes affiliated with Tauopathy

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16Gene Ontology
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Cellular components related to Tauopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inclusion bodyGO:01623410.4SNCA, HTT
2axonGO:03042410.3CDK5, MAPT, SNCA, PSEN1, HTT
3growth coneGO:03042610.2PSEN1, SNCA, MAPT, CDK5
4cytosolGO:0058299.8RPS27A, CAMK2G, HTT, NPEPPS, STUB1, SNCA

Biological processes related to Tauopathy according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1dopamine uptake involved in synaptic transmissionGO:05158310.7PARK7, SNCA
2regulation of locomotionGO:04001210.7SNCA, LRRK2
3negative regulation of neuron apoptotic processGO:04352410.7PARK7, SNCA, PSEN1, HTT
4neuron apoptotic processGO:05140210.6HTT, PSEN1, CDK5
5regulation of synaptic plasticityGO:04816710.6HTT, PSEN1, CDK5
6positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:03243610.6LRRK2, STUB1, PSEN1
7peptidyl-threonine phosphorylationGO:01810710.6MAPK8, CDK5, LRRK2
8positive regulation of receptor recyclingGO:00192110.6SNCA, PSEN1
9autophagyGO:00691410.6NPC1, LRRK2, PARK7
10axon cargo transportGO:00808810.6MAPT, HTT
11peptidyl-serine phosphorylationGO:01810510.6LRRK2, CDK5, MAPK8
12behavioral response to cocaineGO:04814810.5CDK5, SNCA
13determination of adult lifespanGO:00834010.5HTT, LRRK2
14positive regulation of apoptotic processGO:04306510.4RPS27A, PSEN1, PPP2R4, MAPK8
15synaptic vesicle endocytosisGO:04848810.4CDK5, SNCA
16protein polyubiquitinationGO:00020910.3STUB1, NPEPPS, RPS27A
17neuron migrationGO:00176410.3PSEN1, MAPT, CDK5
18axon extensionGO:04867510.1CDK5, MAPT

Molecular functions related to Tauopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Hsp70 protein bindingGO:03054410.4SNCA, STUB1
2protein bindingGO:0055159.6PARK7, CAMK2G, HTT, NPC1, PSEN1, STUB1

Products for genes affiliated with Tauopathy

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Sources for Tauopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet