Tauopathy malady

Disease Ontology: A neurodegenerative disease that has material basis in the pathological aggregation of tau protein in so-called neurofibrillary tangles (nft) in the human brain.⁶

MalaCards: Tauopathy, also known as tauopathies, is related to alzheimer's disease and pick's disease. An important gene associated with Tauopathy is MAPT (microtubule-associated protein tau), and among its related pathways are Protein Stability and Alzheimers Disease Pathway. The compounds thioflavine s and lysine have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and b cells, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia: Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of...⁴⁴ more...

Aliases & Descriptions:

tauopathy 6 tauopathies 32 43

Diseases related to tauopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 271)

id	Related Disease	Score	Top Affiliating Genes
1	alzheimer's disease	33.1	APOE, APP, MAPT, PSEN1, PRNP
2	pick's disease	31.8	MAPT, PSEN1
3	parkinson's disease	31.2	PARK7, UCHL1, MAPT, SNCA
4	frontotemporal dementia	29.3	PIN1, SERPINI1, VCP, PARK2, CDKN3, INA
5	lateral sclerosis	29.2	MAPT, SNCA, SOD1
6	inclusion body myositis	28.5	APP, MAPT, RPS27A
7	lewy body dementia	28.2	SNCB, SNCA
8	transient cerebral ischemia	27.8	CDK5, MAPT, MAP2, CASP3, CAMK2G, RPS27A
9	corticobasal degeneration	27.7	MAPT, CASP3, SNCA, RPS27A, TARDBP
10	progressive supranuclear palsy	26.6	PARK7, PARK2, CDK5, APOE, APP, MAPT
11	dementia	26.3	PIN1, SERPINI1, VCP, PARK7, PARK2, UCHL1
12	multiple system atrophy	25.5	PARK7, PARK2, UCHL1, UBB, CDK5, APOE
13	myositis	24.6	VCP, PARK7, PARK2, UBB, CDK5, IL2
14	supranuclear palsy	24.4	BMS1, PARK7, PARK2, MOBP, CD8B, CDK5
15	brain injury	23.6	SERPINI1, UCHL1, CDKN3, GRN, APOE, APP
16	neurodegenerative disease	23.6	PIN1, SERPINI1, VCP, PARK7, PARK2, UNG
17	neurodegeneration	22.8	PIN1, SERPINI1, VCP, PARK7, PARK2, UCHL1
18	amyotrophic lateral sclerosis	22.7	VCP, PARK7, PARK2, UBC, CDK5, CDK5R1
19	cerebritis	21.4	SERPINI1, NAGLU, PARK7, PARK2, UBC, MOBP
20	ischemia	20.7	SERPINI1, NAGLU, PARK7, PARK2, UBC, CDK5
21	neuronitis	18.8	PIN1, SERPINI1, VCP, RARRES3, PARK7, PARK2
22	primary progressive aphasia	13.9	GRN, MAPT, RPS27A
23	familial idiopathic basal ganglia calcification	13.8	APP, MAPT, PSEN1
24	niemann-pick disease type c1	13.8	APP, MAPT, SNCA, NPC1
25	basal ganglia calcification	13.8	APP, MAPT, PSEN1
26	parkinson disease 10	13.8	PARK7, PARK2, SNCA, LRRK2
27	early-onset familial alzheimer disease	13.8	SERPINI1, APP, MAPT, SNCA, PSEN1
28	parkinson disease type 3	13.8	PARK7, PARK2, MAPT, SNCA, LRRK2
29	fibrillary astrocytoma	13.8	APP, SNCB, SNCA
30	niemann–pick disease	13.8	APP, MAPT, SNCA, NPC1
31	neuronal intranuclear inclusion disease	13.7	MAPT, SNCA, RPS27A
32	hereditary cerebral hemorrhage with amyloidosis	13.7	APP, RPS27A, PSEN1
33	logopenic progressive aphasia	13.7	MAPT, SNCA
34	movement disease	13.7	PARK7, PARK2, MAPT, HTT, SNCA, RPS27A
35	frontotemporal dementia, ubiquitin-positive	13.7	MAPT, SNCA
36	apraxia	13.6	GRN, MAPT, HTT, PSEN1
37	aneurysmal bone cysts	13.6	CDK5, MAPT, SLCO1A2
38	gaze palsy	13.6	MAPT, SNCA, TARDBP
39	neuroaxonal dystrophy	13.6	APP, SNCA, RPS27A
40	striatonigral degeneration	13.6	MAP2, SNCA, RPS27A
41	tremor	13.6	PARK7, PARK2, UCHL1, CDKN3, SNCA, LRRK2
42	prion disease	13.6	APP, MAPT, PSEN1, PRNP
43	olivopontocerebellar atrophy	13.6	MAP2, GLUD1, SNCA
44	wernicke encephalopathy	13.5	INA, MAPT, PRNP
45	alzheimer disease type 1	13.5	APOE, APP, MAPT, PSEN1
46	binswanger's disease	13.5	APOE, APP, MAPT
47	alzheimer disease type 2	13.5	APOE, APP, MAPT, PSEN1
48	frontotemporal lobar degeneration with ubiquitin-positive inclusions	13.5	GRN, LOC643387, RPS27A, TARDBP, SQSTM1
49	ganglioglioma	13.5	CDK5, CDK5R1, MAP2, SNCA
50	inclusion body myopathy	13.4	VCP, APP, SNCA, RPS27A, TARDBP, PSEN1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to tauopathy:

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MGI Mouse Phenotypes related to tauopathy:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.4	SIRT1, NPC1, PSEN1, LRRK2, NDUFS4, CRHR1
2	endocrine/exocrine gland phenotype	MP:0005379	9.1	NPEPPS, PSEN1, SYT1, LRRK2, CRHR1, GLUD1
3	no phenotypic analysis	MP:0003012	9.0	SNCA, LRRK2, TARDBP, PRNP, SIRT1, SNCB
4	liver/biliary system phenotype	MP:0005370	8.9	SIRT1, NPC1, SOD1, SQSTM1, PRKAB1, IL2
5	taste/olfaction phenotype	MP:0005394	8.9	SNCA, CTNNB1, CASP3, HTT, MAPT
6	hematopoietic system phenotype	MP:0005397	8.7	GAPDH, USP1, UNG, SOD2, SQSTM1, PRDX2
7	integument phenotype	MP:0010771	8.6	SNCA, NDUFS4, LRRK2, TGM1, PSEN1, SQSTM1
8	other phenotype	MP:0005395	8.5	SOD2, PRNP, PSEN1, MAPT, APP, APOE
9	reproductive system phenotype	MP:0005389	8.4	SNCA, PRNP, SOD2, NPC1, NPEPPS, SIRT1
10	nervous system phenotype	MP:0003631	7.9	LRRK2, NDUFS4, SNCA, HTT, MAP2, MAPK8
11	normal phenotype	MP:0002873	7.8	SNCB, CRHR1, NDUFS4, SYT1, PSEN1, PRDX6
12	skeleton phenotype	MP:0005390	7.7	SQSTM1, EIF2AK3, NDUFS4, SNCA, CTNNB1, SP1
13	muscle phenotype	MP:0005369	7.3	SOD2, SOD1, PRNP, PRKAB1, PSEN1, NDUFS4
14	renal/urinary system phenotype	MP:0005367	7.2	PSEN1, PRDX6, SOD2, SIRT1, EP300, GAPDH
15	immune system phenotype	MP:0005387	7.0	PSEN1, PRKAB1, PRNP, SQSTM1, SOD2, NPC1
16	vision/eye phenotype	MP:0005391	6.2	PSEN1, PRKAB1, SOD1, SOD2, NPC1, SIRT1
17	behavior/neurological phenotype	MP:0005386	5.3	SIRT1, NPEPPS, NPC1, SOD2, SQSTM1, PRNP
18	cardiovascular system phenotype	MP:0005385	5.1	CRHR1, NDUFS4, LRRK2, PSEN1, PRDX6, SOD1
19	mortality/aging	MP:0010768	5.0	GAPDH, EP300, SIRT1, NPEPPS, NPC1, SQSTM1
20	growth/size phenotype	MP:0005378	3.1	GAPDH, EP300, SIRT1, NPEPPS, NPC1, SOD2
21	cellular phenotype	MP:0005384	3.1	NPC1, SOD2, SOD1, SQSTM1, PRNP, PRKAB1
22	homeostasis/metabolism phenotype	MP:0005376	3.0	SP1, UBB, UNG, PARK2, PARK7, USP1

Articles related to tauopathy:

(show top 50)    (show all 148)

id	Title	Authors	Year	Affiliating Genes
1	Chronic stress exacerbates tau pathology, neurodegene ration, and cognitive performance through a corticotropin-releasing factor rece ptor-dependent mechanism in a transgenic mouse model of tauopathy. (21976528)	Carroll J.C.... Trojanowski J.Q.	2011	MAPT, CRHR1
2	Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (21685912)	HAPglinger G.U.... Schellenberg G.D.	2011	MAPT, IL2, IRF4
3	Upper airway dysfunction of Tau-P301L mice correlates with tauopathy in midbrain and ponto-medullary brainstem nuclei. (20130190)	Dutschmann M.... Van Leuven F.	2010	MAPT
4	Tau in Alzheimer disease and related tauopathies. (20678074)	Iqbal K.... Grundke-Iqbal I.	2010	MAPT
5	Acetylation of tau inhibits its degradation and contr ibutes to tauopathy. (20869593)	Min S.W.... Gan L.	2010	MAPT, EP300, SIRT1
6	Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies. (19238406)	Zilka N.... Novak M.	2009	MAPT
7	Small-molecule mediated neuroprotection in an in situ model of tauopathy. (19384600)	Honson N.S.... Kuret J.	2009	MAPT
8	Transmission and spreading of tauopathy in transgenic mouse brain. (19503072)	Clavaguera F.... Tolnay M.	2009	MAPT
9	Repression of tau hyperphosphorylation by chronic end urance exercise in aged transgenic mouse model of tauopathies. (19360903)	Leem Y.H.... Han P.L.	2009	TCF4
10	NAP protects memory, increases soluble tau and reduce s tau hyperphosphorylation in a tauopathy model. (19264130)	Shiryaev N.... Gozes I.	2009	MAPT
11	Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. (18322384)	Gotz J.... Ittner L.M.	2008	VCP
12	Tau exon 10 alternative splicing and tauopathies. (18616804)	Liu F.... Gong C.X.	2008	MAPT
13	Identification of non-Alzheimer's disease tauopathies-related proteins by proteomic analysis. (18647502)	Yang G.... Xu D.	2008	GAPDH, SOD2, ENO1
14	Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy. (18079436)	Delobel P.... Goedert M.	2008	MAPT
15	A novel calcium-binding protein is associated with tau proteins in tauopathy. (18346207)	Vega I.E.... Yen S.H.	2008	MAPT
16	Relation of hippocampal phospho-SAPK/JNK granules in Alzheimer's disease and tauopathies to granulovacuolar degeneration bodies. (17089132)	Lagalwar S.... Binder L.I.	2007	MAPT, MAPK8
17	Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis? (17318305)	Mollenhauer B.... Otto M.	2007	APP, SNCA
18	Tau aggregation and toxicity in a cell culture model of tauopathy. (17428800)	Bandyopadhyay B.... Kuret J.	2007	MAPT
19	Tauopathies. (17604998)	HernA!ndez F.... Avila J.	2007	MAPT
20	Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. (16571759)	Boekhoorn K.... Lucassen P.J.	2006	MAPT
21	Animal models of tauopathies (17432223)	Higuchi M.	2006	MAPT
22	Ultrastructural characteristics of tau filaments in tauopathies: immuno-electron microscopic demonstration of tau filaments in tauopathies. (17080728)	Arima K.	2006	MAPT
23	Expression of a truncated tau protein induces oxidative stress in a rodent model of tauopathy. (16930434)	Cente M.... Novak M.	2006	MAPT
24	Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies. (17050703)	Reynolds M.R.... Binder L.I.	2006	MAPT
25	Tau protein as a differential biomarker of tauopathies. (15615637)	Sergeant N.... BuAce L.	2005	MAPT
26	Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. (15615853)	Zhang B.... Trojanowski J.Q.	2005	MAPT
27	Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model. (16238489)	Yoshiyama Y.... Trojanowski J.Q.	2005	MAPT
28	Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. (15867159)	Noble W.... Duff K.	2005	MAPT
29	Tau pathology in Alzheimer disease and other tauopathies. (15615638)	Iqbal K.... Grundke-Iqbal I.	2005	MAPT, MAP2
30	Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies. (15977985)	Ferrer I.... Avila J.	2005	MAPT
31	Quantitative analysis of tau isoform transcripts in sporadic tauopathies. (15950767)	Connell J.W.... Gallo J.M.	2005	MAPT
32	Frequency of tau mutations in familial and sporadic frontotemporal dementia and other tauopathies. (15372253)	Stanford P.M.... Schofield P.R.	2004	MAPT
33	Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies. (15050686)	Umeda Y.... Hasegawa M.	2004	MAPT
34	Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology. (14695329)	Dabir D.V.... Forman M.S.	2004	MAPT, SNCA
35	The role of tau (MAPT) in frontotemporal dementia and related tauopathies. (15365985)	Rademakers R.... Van Broeckhoven C.	2004	MAPT
36	Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice. (15658002)	Ferrer I.	2004	APP, MAPT
37	Dementia with Lewy bodies from the perspective of tauopathy. (12557014)	Iseki E.... Kosaka K.	2003	MAPT
38	An English kindred with a novel recessive tauopathy and respiratory failure. (14595660)	Nicholl D.J.... Heutink P.	2003	MAPT
39	The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy. (12883828)	Hogg M.... Bigio E.H.	2003	MAPT
40	Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies. (12805366)	Makrides V.... Feinstein S.C.	2003	MAPT
41	Genetic modifiers of tauopathy in Drosophila. (14668378)	Shulman J.M.... Feany M.B.	2003	MAPT, CDKN3
42	Guadeloupean parkinsonism: a cluster of progressive s upranuclear palsy-like tauopathy. (11912113)	Caparros-Lefebvre D.... Duyckaerts C.	2002	NDUFS4
43	Early-onset, rapidly progressive familial tauopathy with R406W mutation. (11889249)	Saito Y.... Murayama S.	2002	MAPT
44	Tauopathies--a new class of neurodegenerative diseases (11256158)	Ludolph A.C.... Storch A.	2001	MAPT
45	Transgenic mouse models of tauopathies: prospects for animal models of Pick's disease. (11402147)	Lee V.M.... Trojanowski J.Q.	2001	MAPT
46	Dynamic neuropathology of tauopathy (12235808)	Murayama S.	2001	MAPT
47	New insights into genetic and molecular mechanisms of brain degeneration in tauopathies. (11207421)	Forman M.S.... Trojanowski J.Q.	2000	MAPT
48	Progress in hereditary tauopathies: a mutation in the Tau gene (G389R) causes a Pick disease-like syndrome. (11193177)	Ghetti B.... Goedert M.	2000	MAPT
49	A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy. (10412802)	Delisle M.-B.... Ghetti B.	1999	MAPT
50	Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments. (9108114)	Spillantini M.G.... Ghetti B.	1997	MAPT

Genes related to tauopathy according to GeneCards:

(show top 50)    (show all 71)

id	Symbol	Description	Score	GeneCards Section Context
1	MAPT	microtubule-associated protein tau	11.0	Publications
2	STH	saitohin	11.0
3	TRA2B	transformer 2 beta homolog (Drosophila)	11.0
4	INA	internexin neuronal intermediate filament protein, alpha	11.0
5	STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	11.0	Publications
6	CDK5	cyclin-dependent kinase 5	11.0	Publications
7	GRN	granulin	11.0
8	PARK7	parkinson protein 7	11.0	Publications
9	NPEPPS	aminopeptidase puromycin sensitive	11.0	Publications
10	NPC1	Niemann-Pick disease, type C1	11.0	Publications
11	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Publications
12	SERPINI1	serpin peptidase inhibitor, clade I (neuroserpin), member 1	11.0
13	CAMK2G	calcium/calmodulin-dependent protein kinase II gamma	11.0	Publications
14	RPS27A	ribosomal protein S27a	11.0	Publications
15	PSEN1	presenilin 1	11.0	Publications
16	LRRK2	leucine-rich repeat kinase 2	11.0	Publications
17	PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	11.0
18	APP	amyloid beta (A4) precursor protein	11.0	Publications
19	CDKN3	cyclin-dependent kinase inhibitor 3	11.0	Publications
20	HTT	huntingtin	11.0
21	MAPK8	mitogen-activated protein kinase 8	11.0	Publications
22	PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	11.0
23	LOC643387	TAR DNA binding protein pseudogene	11.0	Publications
24	RARRES3	retinoic acid receptor responder (tazarotene induced) 3	11.0	Publications
25	ECHS1	enoyl CoA hydratase, short chain, 1, mitochondrial	11.0	Publications
26	USP1	ubiquitin specific peptidase 1	11.0	Publications
27	SNCB	synuclein, beta	11.0	Publications
28	CD8B	CD8b molecule	11.0	Publications
29	ZC3H14	zinc finger CCCH-type containing 14	11.0	Publications
30	PRDX6	peroxiredoxin 6	11.0	Publications
31	PRDX2	peroxiredoxin 2	11.0	Publications
32	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	11.0	Publications
33	TGM1	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)	11.0	Publications
34	STX6	syntaxin 6	11.0	Publications
35	IRF4	interferon regulatory factor 4	11.0	Publications
36	BMS1	BMS1 homolog, ribosome assembly protein (yeast)	11.0	Publications
37	MOBP	myelin-associated oligodendrocyte basic protein	11.0	Publications
38	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	11.0	Publications
39	ENO1	enolase 1, (alpha)	11.0	Publications
40	UNG	uracil-DNA glycosylase	11.0	Publications
41	VCP	valosin containing protein	11.0	Publications
42	SLCO1A2	solute carrier organic anion transporter family, member 1A2	11.0	Publications
43	EIF2AK3	eukaryotic translation initiation factor 2-alpha kinase 3	11.0	Publications
44	DPYSL2	dihydropyrimidinase-like 2	11.0	Publications
45	CAPN1	calpain 1, (mu/I) large subunit	11.0	Publications
46	UBB	ubiquitin B	11.0	UniProt Related
47	GLUD1	glutamate dehydrogenase 1	11.0	Publications
48	PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	11.0	Publications
49	PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	11.0	Publications
50	IL21	interleukin 21	11.0	Publications

Pathways related to tauopathy according to GeneDecks:

(show all 17)

id	Pathway	Score	Top Affiliating Genes
1	Protein Stability3	10.0	SQSTM1, STUB1, CAPN1, UCHL1, PARK2, USP1
2	Alzheimers Disease Pathway36	9.9	PSEN1, CAPN1, MAPT, APP, APOE, CDK5R1
3	Protein processing in endoplasmic reticulum20	9.9	VCP, PARK2, MAPK8, CAPN1, EIF2AK3, STUB1
4	TRAF6 mediated induction of TAK1 complex38	9.9	RPS27A, UBC, UBB
5	Parkinsons Disease Pathway36	9.9	STUB1, SNCA, UBC, UBB, UCHL1, PARK2
6	Immune response_MIF-JAB1 signaling41	9.8	UCHL1, UBB, UBC, MAPK8
7	CDK5 Pathway36	9.8	CAPN1, MAPT, CDK5R1, CDK5, UBC, UBB
8	Proteolysis_Putative ubiquitin pathway41	9.8	PARK2, UBB, UBC, STUB1
9	Reelin Pathway (Cajal-Retzius cells)36	9.4	PPP2R4, CTNNB1, MAPK8, MAPT, APP, APOE
10	Regulation of degradation of wt-CFTR41	9.4	STUB1, UBC, UBB, VCP
11	Glucose / Energy Metabolism3	9.3	GAPDH, SIRT1, PRKAB1, GLUD1, MARK1, ENO1
12	Parkinsons disease20	9.2	LRRK2, NDUFS4, SNCA, CASP3, UBB, UCHL1
13	p53 Signaling36	8.7	EP300, SIRT1, CASP3, MAPK8, UBC, UBB
14	Presenilin-Mediated Signaling36	8.6	PSEN1, CTNNB1, CASP3, APP, UBC, UBB
15	Alzheimers disease20	8.4	SNCA, NDUFS4, EIF2AK3, PSEN1, GAPDH, CASP3
16	Neuroscience3	8.2	PARK7, SNCB, SNCA, LRRK2, DPYSL2, TARDBP
17	Huntingtons disease20	8.0	EP300, SOD2, SOD1, NDUFS4, SP1, CASP3

Compounds related to tauopathy according to GeneDecks:

(show top 50)    (show all 168)

id	Compound	Score	Top Affiliating Genes
1	thioflavine s32	10.2	APP, RPS27A, APOE, MAPT, SNCA
2	lysine32	9.8	SYT1, PRNP, PARK7, SIRT1, PSEN1, PARK2
3	glucose32	9.8	GRN, GAPDH, PARK2, CDK5, CDK5R1, ENO1
4	nadph32 18	10.8	NDUFS4, GLUD1, MAPT, SQSTM1
5	alanine32	9.8	PIN1, NAGLU, PARK2, HTT, CAMK2G, GLUD1
6	levodopa32 9 9	11.6	SOD1, PARK7, LRRK2, NDUFS4, RPS27A, SNCA
7	n acetylcysteine32	9.4	RPS27A, PRKAB1, NAGLU, CDK5, APOE, MAPT
8	mg 13232 42	10.3	PARK2, MAPT, CASP3, PPP2R4, SNCA, RPS27A
9	threonine32	9.3	PARK2, UNG, CDK5, CDK5R1, MAPT, MAP2
10	sodium dodecylsulfate32	9.3	APP, MAPT, GLUD1, SNCA, RPS27A, PRNP
11	formate32	9.2	APOE, PRNP, RPS27A, SNCA, HTT, MAPT
12	glyceraldehyde 3-phosphate32	9.1	GLUD1, UNG, UCHL1, ENO1, PRDX2, PRDX6
13	nitric oxide32 9 18 9	12.1	CAPN1, TGM1, CRHR1, EIF2AK3, SIRT1, EP300
14	proline32	9.1	RPS27A, PARK2, MAPT, MAP2, HTT, CAPN1
15	lactacystin32	9.0	RPS27A, PSEN1, SNCA, CASP3, CDKN3, APOE
16	tacrolimus32 34 9 9	12.0	GAPDH, RPS27A, PPP2R4, CAMK2G, APP, IL2
17	peroxynitrite32	8.9	GAPDH, SOD2, SOD1, PRDX6, PSEN1, NDUFS4
18	glycogen32 18	9.8	HTT, MAP2, MAPT, CDK5R1, CDK5, PARK2
19	rapamycin32 42	9.8	HTT, CAMK2G, GLUD1, SP1, PPP2R4, SNCA
20	rotenone32	8.6	SNCA, SOD1, SOD2, NDUFS4, RPS27A, CASP3
21	cyclosporin a32 42	9.5	NAGLU, CDKN3, IL2, PIN1, APOE, APP
22	dopamine32 9 18 9	11.5	NAGLU, PARK7, PARK2, SYT1, GAPDH, NDUFS4
23	acetylcholine32 9 18 9	11.4	CDKN3, SYT1, APOE, SNCA, RPS27A, SOD2
24	6-hydroxydopamine32	8.4	PARK7, PARK2, CDK5, APP, CASP3, SNCA
25	nmda32 42	9.4	CTNNB1, GAPDH, PSEN1, PARK2, CDK5, APOE
26	calcium32 9 18 9	11.3	ENO1, PIN1, CDK5, MAP2, HTT, CAPN1
27	arginine32	8.3	SOD1, TGM1, RPS27A, SNCA, PRNP, PSEN1
28	thapsigargin32 42	9.1	CAPN1, PPP2R4, EIF2AK3, PSEN1, GAPDH, MAPK8
29	4-hydroxynonenal32 18	9.1	GAPDH, SOD2, APOE, APP, ENO1, MAPT
30	aspartate32	8.0	PIN1, NAGLU, APOE, ENO1, APP, GLUD1
31	ly29400232	8.0	SOD2, CDKN3, PRKAB1, PPP2R4, SP1, CAMK2G
32	oxygen32 18	8.9	GLUD1, PPP2R4, SNCA, NDUFS4, EIF2AK3, PSEN1
33	h2o232	7.9	MAPT, MAPK8, CAMK2G, GLUD1, SP1, PPP2R4
34	paclitaxel32 34 9 9	10.9	SOD2, PIN1, PARK2, CASP3, CDK5, APP
35	creatinine32	7.9	APOE, SOD1, PRDX2, ENO1, GAPDH, DPYSL2
36	glutamate32	7.7	RPS27A, NDUFS4, DPYSL2, SYT1, PRDX6, GAPDH
37	testosterone32 9 18 9	10.6	PARK7, PARK2, CDKN3, APOE, APP, GAPDH
38	actinomycin d32	7.4	APOE, APP, MAPT, MAPK8, SOD2, CDKN3
39	lactate32	7.4	NAGLU, CASP3, HTT, MAP2, MAPT, ENO1
40	glutamine32	7.3	PPP2R4, SNCA, RPS27A, EIF2AK3, TGM1, STUB1
41	retinoic acid32 42 18	9.3	RARRES3, EP300, PRDX2, TGM1, HTT, RPS27A
42	cisplatin32 34 9 9	10.2	EP300, NAGLU, SOD2, RPS27A, GAPDH, CTNNB1
43	lipid32	7.1	PRDX6, PRKAB1, PRNP, SOD1, SOD2, NPC1
44	atp32	7.0	CAPN1, PRDX6, PRKAB1, PARK2, VCP, CDKN3
45	cycloheximide32	6.9	UNG, CDKN3, IL2, APOE, MAPT, MAPK8
46	cysteine32	6.7	CASP3, GLUD1, SP1, CTNNB1, PPP2R4, SNCA
47	vegf32	6.2	CASP3, RPS27A, GAPDH, EP300, SOD2, PRKAB1
48	superoxide32 18	7.1	NAGLU, VCP, PARK7, PARK2, UNG, UCHL1
49	tyrosine32	6.0	RPS27A, SNCA, CRHR1, EIF2AK3, SYT1, STUB1
50	serine32	4.7	CAMK2G, MAPK8, CASP3, HTT, MAP2, MAPT

Cellular components related to tauopathy according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	growth cone	GO:030426	10.2	DPYSL2, SNCA, MAPT, CDK5R1, CDK5
2	axon	GO:030424	10.2	SNCA, HTT, MAPT, APP, CDK5R1, CDK5
3	endocytic vesicle membrane	GO:030666	9.6	SYT1, RPS27A, CAMK2G, UBC, UBB
4	protein-DNA complex	GO:032993	9.2	EP300, CTNNB1, SP1
5	perinuclear region of cytoplasm	GO:048471	9.1	GAPDH, NPC1, STX6, SNCA, CTNNB1, CDKN3
6	neuronal cell body	GO:043025	8.9	SOD1, DPYSL2, LRRK2, MAP2, APOE, CDK5R1
7	mitochondrion	GO:005739	7.8	NDUFS4, LRRK2, DPYSL2, PSEN1, SOD1, SOD2
8	nucleoplasm	GO:005654	7.3	EP300, SIRT1, SQSTM1, RPS27A, SP1, CAMK2G
9	nucleolus	GO:005730	6.9	PPP2R4, SNCB, TARDBP, PRNP, SOD1, SIRT1
10	cytosol	GO:005829	6.1	CAMK2G, CTNNB1, SNCA, RPS27A, DPYSL2, STUB1
11	plasma membrane	GO:005886	5.3	CTNNB1, SNCA, CRHR1, RPS27A, LRRK2, SYT1
12	nucleus	GO:005634	4.8	TCF4, SNCA, SNCB, PPP2R4, CTNNB1, SP1
13	cytoplasm	GO:005737	4.4	GAPDH, SP1, CTNNB1, PPP2R4, SNCB, SNCA

Biological processes related to tauopathy according to GeneDecks:

(show all 32)

id	Name	GO ID	Score	Top Affiliating Genes
1	axon cargo transport	GO:008088	10.6	HTT, MAPT, APP
2	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO:032436	10.5	PSEN1, STUB1, LRRK2, VCP
3	dopamine uptake involved in synaptic transmission	GO:051583	10.4	SNCA, PARK7
4	peptidyl-threonine phosphorylation	GO:018107	10.3	LRRK2, MAP2, MAPK8, CDK5R1, CDK5
5	Notch receptor processing	GO:007220	10.1	UBB, UBC, RPS27A, PSEN1
6	autophagy	GO:006914	10.0	NPC1, SQSTM1, LRRK2, PARK7
7	response to oxidative stress	GO:006979	10.0	SIRT1, PRNP, PRDX6, PRDX2, PSEN1, LRRK2
8	egress of virus within host cell	GO:046788	10.0	UBB, UBC, RPS27A
9	protein polyubiquitination	GO:000209	10.0	NPEPPS, STUB1, RPS27A, UBC, UBB, PARK2
10	negative regulation of type I interferon production	GO:032480	9.9	PIN1, UBB, UBC, RPS27A
11	endosomal transport	GO:016197	9.9	SQSTM1, RPS27A, HTT, UBC, UBB
12	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	9.9	UBB, UBC, APP, RPS27A
13	neuron migration	GO:001764	9.9	PSEN1, CTNNB1, MARK1, MAPT, CDK5R1, CDK5
14	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061418	9.8	EP300, RPS27A, UBC, UBB
15	negative regulation of transforming growth factor beta receptor signaling pathway	GO:030512	9.8	SIRT1, STUB1, RPS27A, UBC, UBB, PIN1
16	removal of superoxide radicals	GO:019430	9.8	PRDX2, SOD1, SOD2
17	JNK cascade	GO:007254	9.7	RPS27A, MAPK8, UBC, UBB
18	cellular response to stress	GO:033554	9.7	EP300, RPS27A, UBC, UBB
19	Notch signaling pathway	GO:007219	9.7	EP300, PSEN1, RPS27A, APP, UBC, UBB
20	cellular response to hypoxia	GO:071456	9.6	EP300, SIRT1, NPEPPS, RPS27A, UBC, UBB
21	negative regulation of neuron apoptotic process	GO:043524	9.6	SOD2, SOD1, PSEN1, SNCA, SNCB, HTT
22	neuron apoptotic process	GO:051402	9.6	GAPDH, PSEN1, CASP3, HTT, APP, CDK5
23	DNA repair	GO:006281	9.6	SIRT1, STUB1, RPS27A, UBC, UBB, UNG
24	stress-activated MAPK cascade	GO:051403	9.4	RPS27A, MAPK8, UBC, UBB
25	transforming growth factor beta receptor signaling pathway	GO:007179	9.4	UBB, UBC, SP1, RPS27A, STUB1
26	activation of MAPK activity	GO:000187	9.3	SOD1, LRRK2, RPS27A, UBC, UBB
27	induction of apoptosis by extracellular signals	GO:008624	9.1	SQSTM1, PSEN1, RPS27A, CASP3, MAPK8, UBC
28	nerve growth factor receptor signaling pathway	GO:048011	8.9	SQSTM1, PSEN1, RPS27A, CASP3, MAPK8, UBC
29	regulation of apoptotic process	GO:042981	8.9	SIRT1, PRDX2, RPS27A, CASP3, CDK5, UBC
30	response to drug	GO:042493	8.9	EP300, NPC1, SOD1, DPYSL2, SNCA, CTNNB1
31	anti-apoptosis	GO:006916	7.9	UBB, SOD1, SQSTM1, PRNP, PRDX2, PSEN1
32	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.6	EP300, SIRT1, SQSTM1, TCF4, RPS27A, CTNNB1

Molecular functions related to tauopathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	p53 binding	GO:002039	9.8	EP300, SIRT1, HTT, CDK5
2	superoxide dismutase activity	GO:004784	9.6	SOD1, SOD2
3	antioxidant activity	GO:016209	9.6	APOE, PRDX2, PRDX6
4	identical protein binding	GO:042802	8.9	SIRT1, SQSTM1, PRNP, EIF2AK3, SNCA, GLUD1
5	protein binding	GO:005515	1.9	GAPDH, SYT1, TARDBP, TCF4, DPYSL2, TGM1