MCID: TPT001
MIFTS: 50

Tauopathy malady

Summaries for Tauopathy

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A neurodegenerative disease that has material basis in the pathological aggregation of tau protein in so-called neurofibrillary tangles (nft) in the human brain.

MalaCards: Tauopathy, also known as tauopathies, is related to frontotemporal dementia and alzheimer's disease. An important gene associated with Tauopathy is MAPT (microtubule-associated protein tau), and among its related pathways are Parkinsons Disease Pathway and Alpha-synuclein signaling. The compounds thioflavine s and formate have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and retina, and related mouse phenotypes are endocrine/exocrine gland and cellular.

Wikipedia:64 Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of... more...

Aliases & Classifications for Tauopathy

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 35MeSH
See all sources

Aliases & Descriptions:

tauopathy 8
tauopathies 45 61


External Ids:

Disease Ontology8 DOID:680
MeSH35 D024801

Related Diseases for Tauopathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tauopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1frontotemporal dementia30.8PSEN1, MAPT
2alzheimer's disease30.6NPEPPS, HTT, CAMK2G, RPS27A, GRN, SERPINI1
3progressive supranuclear palsy30.5RPS27A, MAPT, CDK5, LRRK2, PARK7, SNCA
4parkinson's disease30.5PARK7, CAMK2G, RPS27A, HTT, PSEN1, STUB1
5pick's disease30.4MAPT, PSEN1
6brain disease30.4MAPT, SNCA, SERPINI1, PSEN1
7lateral sclerosis30.4MAPT, SNCA
8amyotrophic lateral sclerosis30.4SNCA, PSEN1, GRN, MAPT, RPS27A, HTT
9aphasia30.1GRN, MAPT
10transient cerebral ischemia30.1CAMK2G, RPS27A
11primary progressive aphasia30.1RPS27A, MAPT, GRN
12lewy body dementia29.8LRRK2, MAPT, SNCA
13semantic dementia29.8RPS27A, MAPT, GRN
14memory impairment29.8MAPT, GRN, SNCA, CDK5, PSEN1
15amyloidosis29.8RPS27A, MAPT, SNCA, PSEN1
16inclusion body myositis29.8MAPT, RPS27A
17corticobasal degeneration10.4
18argyrophilic grain disease10.3
19sleep disorder10.2
20tau syndrome10.2
21brain injury10.2
22amyotrophic lateral sclerosis-parkinsonism/dementia complex10.2
23traumatic brain injury10.1
24tauopathy and respiratory failure10.1
25huntington's disease10.0HTT
26myopathy10.0RPS27A
27neuronal intranuclear inclusion disease10.0RPS27A
28apraxia10.0MAPT, GRN
29schizophrenia10.0NPEPPS, PSEN1, SNCA
30niemann-pick disease10.0MAPT, SNCA, NPC1
31brain ischemia10.0MAPT, CAMK2G
32parkinson disease type 310.0SNCA, LRRK2, MAPT, PARK7
33niemann–pick disease10.0NPC1
34rem sleep behavior disorder10.0SNCA
35myositis10.0MAPT, SNCA, PSEN1, RPS27A
36creutzfeldt-jakob syndrome10.0MAPT, RPS27A, SNCA
37vascular dementia10.0PSEN1, MAPT, RPS27A, SNCA
38spinocerebellar ataxia10.0MAPT, SNCA, RPS27A, HTT
39diabetes mellitus10.0MAPK8
40down syndrome10.0MAPT, PSEN1, SNCA
41frontotemporal lobar degeneration with ubiquitin-positive inclusions10.0GRN
42pancreatic cancer10.0MAPK8, RPS27A
43amyloid tumor10.0RPS27A, PSEN1, MAPT
44cerebral amyloid angiopathy10.0PSEN1, MAPT
45astrocytoma10.0MAPK8, SNCA, INA, PSEN1, CDKN3
46multiple system atrophy10.0RPS27A, CDK5, LRRK2, MAPT, SNCA, HTT
47spinocerebellar ataxia type 310.0SNCA, HTT, RPS27A
48motor neuron disease10.0INA, CDK5, MAPT, GRN, RPS27A, HTT
49toxic encephalopathy10.0MAPT, MAPK8, HTT, CDK5
50essential tremor10.0SNCA, LRRK2

Graphical network of the top 20 diseases related to Tauopathy:



Diseases related to tauopathy

Clinical Features for Tauopathy

Drugs & Therapeutics for Tauopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Tauopathy

Drug clinical trials:

Search ClinicalTrials for Tauopathy

Search NIH Clinical Center for Tauopathy

Search CenterWatch for Tauopathy

Genetic Tests for Tauopathy

Anatomical Context for Tauopathy

Sources:
33MalaCards
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MalaCards organs/tissues related to Tauopathy:

33
Brain, Cortex, Retina, T cells, B cells

Animal Models for Tauopathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Tauopathy

Sources:
51PubMed
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Articles related to Tauopathy:

(show top 50)    (show all 232)
idTitleAuthorsYear
1
Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells. (24319659)
2013
2
Neurodegenerative disorder FTDP-17-related tau intron 10 +16C a89 T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice. (23680655)
2013
3
NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy. (23587881)
2013
4
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. (23332170)
2013
5
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. (24050400)
2013
6
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy. (23666556)
2013
7
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy. (22796753)
2013
8
Mutations in MAPT give rise to aneuploidy in animal models of tauopathy. (24218087)
2013
9
Impedance spectroscopy based measurement system for quantitative and label-free real-time monitoring of tauopathy in hippocampal slice cultures. (22221799)
2012
10
Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity. (22611162)
2012
11
NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy. (21965302)
2012
12
Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy. (22426397)
2012
13
Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy. (22689910)
2012
14
Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy. (22976049)
2012
15
CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. (22027994)
2012
16
Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction. (22079237)
2012
17
Induced tauopathy in a novel 3D-culture model mediates neurodegenerative processes: a real-time study on biochips. (23145103)
2012
18
Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: possible implication for neurodegenerative diseases. (22316605)
2012
19
Structural abnormalities in the cortex of the rTg4510 mouse model of tauopathy: a light and electron microscopy study. (21152933)
2011
20
Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity. (20882568)
2010
21
Upper airway dysfunction of Tau-P301L mice correlates with tauopathy in midbrain and ponto-medullary brainstem nuclei. (20130190)
2010
22
Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy. (20513372)
2010
23
SJLB mice develop tauopathy-induced parkinsonism. (20178834)
2010
24
Hippocampal sclerosis with four-repeat tau-positive round inclusions in the dentate gyrus: a new type of four-repeat tauopathy. (19360425)
2009
25
A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. (19363289)
2009
26
NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model. (19264130)
2009
27
Early-onset familial lewy body dementia with extensive tauopathy: a clinical, genetic, and neuropathological study. (19104444)
2009
28
Transmission and spreading of tauopathy in transgenic mouse brain. (19503072)
2009
29
Tauopathy with paired helical filaments in an aged chimpanzee. (18481275)
2008
30
Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice. (18258852)
2008
31
Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy. (18079436)
2008
32
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. (17113760)
2007
33
Cytosine beta-D-arabinofuranoside used as a paradigm modifier to increase production of tau aggregates in a cellular model of tauopathy. (17151917)
2007
34
Accumulation of pathological tau species and memory loss in a conditional model of tauopathy. (17409229)
2007
35
Neuropathology of familial tauopathy. (17080727)
2006
36
A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. (16950154)
2006
37
Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs. (16246844)
2006
38
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. (16651626)
2006
39
Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). (16291936)
2005
40
Progressive neurodegeneration in C. elegans model of tauopathy. (16242642)
2005
41
Neurodegeneration in heterozygous Niemann-Pick type C1 (NPC1) mouse: implication of heterozygous NPC1 mutations being a risk for tauopathy. (15919659)
2005
42
Genetic modifiers of tauopathy in Drosophila. (14668378)
2003
43
Argyrophilic grain disease is a sporadic 4-repeat tauopathy. (12071638)
2002
44
P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein. (12127682)
2002
45
Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam. (12093078)
2002
46
Neurofibrillary degeneration can be arrested in an in vivo cellular model of human tauopathy by application of a compound which inhibits tau filament formation in vitro. (12540050)
2002
47
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. (11408621)
2001
48
Dynamic neuropathology of tauopathy]. (12235808)
2001
49
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. (10595524)
1999
50
Tau gene mutation G389R causes a tauopathy with abundant pick body- like inclusions and axonal deposits. (10604746)
1999

Genetic Variations for Tauopathy

Expression for genes affiliated with Tauopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tauopathy

Search GEO for disease gene expression data for Tauopathy.

Pathways for genes affiliated with Tauopathy

Sources:
38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 30KEGG, 54Reactome, 4Cell Signaling Technology
See all sources

Pathways related to Tauopathy according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4PARK7, LRRK2, SNCA
210.4SNCA, STUB1, PARK7
310.4PSEN1, CDK5, MAPT
4
Hide members
10.4INA, CDK5, MAPT
510.3MAPK8, MAPT, CDK5
6
Hide members
10.3CDK5, MAPK8, CAMK2G, PSEN1
710.3CDK5, MAPT, MAPK8, PPP2R4
8
Hide members
10.3PPP2R4, MAPK8, MAPT, CDK5
910.3CDK5, MAPT, MAPK8, PPP2R4
10
Hide members
10.3MAPK8, MAPT, SNCA, STUB1, PPP2R4
11
Hide members
10.3STUB1, RPS27A, SNCA, MAPT, PARK7, MAPK8
1210.2PARK7, HTT, CAMK2G, PSEN1, MAPT, CDK5
13
Hide members
10.2HTT, PSEN1, MAPK8, MAPT, CDK5, SNCA

Compounds for genes affiliated with Tauopathy

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB
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Compounds related to Tauopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1thioflavine s4510.8RPS27A, SNCA, MAPT
2formate4510.7MAPT, SNCA, RPS27A, HTT
34-hydroxynonenal45 2411.7MAPT, MAPK8, SNCA, PSEN1, RPS27A
4microcystin-lr4510.7CAMK2G, PPP2R4, CDKN3
5nmda45 2911.7MAPT, PPP2R4, HTT, PSEN1, CAMK2G, RPS27A
66-hydroxydopamine4510.7SNCA, RPS27A, CDK5, PARK7
7rotenone4510.7RPS27A, SNCA, MAPK8, PARK7
8lactacystin4510.7PSEN1, SNCA, MAPT, RPS27A, MAPK8, CDKN3
9kainate45 2911.7HTT, CDKN3, MAPT, PSEN1, CAMK2G
10levodopa45 1111.6CDK5, PARK7, RPS27A, CAMK2G, SNCA, CDKN3
11nocodazole45 1111.6CAMK2G, MAPT, CDKN3, PPP2R4, MAPK8
12calyculin a45 60 1112.6PPP2R4, MAPT, CAMK2G, CDKN3
13mg 13245 6011.6PPP2R4, RPS27A, SNCA, MAPK8, MAPT
14phosphoserine45 2411.6MAPT, PPP2R4, CAMK2G, CDKN3
15okadaic acid45 6011.6MAPK8, MAPT, CDKN3, CDK5, CAMK2G, PPP2R4
16n acetylcysteine4510.6MAPT, SNCA, MAPK8, PPP2R4, CDK5, RPS27A
17dopamine45 29 11 2413.6SNCA, RPS27A, CAMK2G, HTT, PPP2R4, CDK5
18proline4510.6RPS27A, CAMK2G, HTT, PSEN1, PPP2R4, CDK5
19geldanamycin45 50 60 1113.6HTT, STUB1, SNCA, RPS27A
20tacrolimus45 50 1112.6SNCA, PPP2R4, CAMK2G, RPS27A, CDKN3
21c2ceramide4510.6PPP2R4, MAPK8, MAPT, CDKN3
22testosterone45 60 11 2413.6CDKN3, PARK7, MAPT, SNCA, STUB1, PPP2R4
23glycogen45 2411.6HTT, RPS27A, PSEN1, SNCA, MAPT, CDKN3
24rapamycin4510.6HTT, MAPK8, CDKN3, PPP2R4, RPS27A, CAMK2G
25superoxide45 2411.5PARK7, CAMK2G, HTT, CDK5, MAPK8, PPP2R4
26thapsigargin45 6011.5MAPK8, PPP2R4, PSEN1, CAMK2G, CDKN3
27glutamine4510.5RPS27A, PSEN1, HTT, NPEPPS, PPP2R4, STUB1
28phosphothreonine4510.5PPP2R4, CDKN3, MAPT
29cycloheximide4510.5PARK7, MAPT, MAPK8, PPP2R4, PSEN1, CDKN3
30glutamate4510.5CDK5, HTT, PSEN1, PPP2R4, RPS27A, SNCA
31alanine4510.5CDKN3, CDK5, MAPT, SNCA, PPP2R4, RPS27A
32cysteine4510.5RPS27A, PSEN1, HTT, NPC1, PPP2R4, SNCA
33lysine4510.5PSEN1, HTT, PPP2R4, SNCA, PARK7, RPS27A
34h2o24510.5PARK7, MAPT, MAPK8, SNCA, CDK5, PPP2R4
35threonine4510.5PSEN1, CAMK2G, PPP2R4, CDKN3, CDK5, MAPK8
36butyrate4510.5HTT, MAPK8, MAPT, CDKN3, RPS27A
37oxygen45 2411.5PARK7, CAMK2G, HTT, PSEN1, PPP2R4, SNCA
38acetylcholine45 50 29 11 2414.5MAPT, RPS27A, CDKN3, CAMK2G, SNCA
39retinoic acid45 2411.5MAPT, INA, CDKN3, PPP2R4, MAPK8, CDK5
40cytochalasin d45 6011.5CDKN3, MAPK8, CAMK2G, MAPT
41glucose4510.4PSEN1, SNCA, MAPT, CAMK2G, HTT, GRN
42cap-p4510.4CDKN3, PPP2R4
43serine4510.4RPS27A, HTT, SERPINI1, CDK5, CDKN3, MAPT
44thioflavin4510.4MAPT, SNCA
45tyrosine4510.4PSEN1, HTT, RPS27A, CAMK2G, PARK7, PPP2R4
46lipid4510.4PPP2R4, PSEN1, HTT, CAMK2G, NPC1, SNCA
47chelerythrine4510.3CAMK2G, MAPK8, CDKN3
48atp45 2911.3CDK5, HTT, NPC1, PPP2R4, CAMK2G, RPS27A
49cytostatin4510.3PPP2R4, CDKN3
50cocaine45 1111.0CDK5, CDKN3, SNCA, CAMK2G

GO Terms for genes affiliated with Tauopathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Tauopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inclusion bodyGO:01623410.4SNCA, HTT
2axonGO:03042410.3PSEN1, CDK5, MAPT, SNCA, HTT
3growth coneGO:03042610.2PSEN1, CDK5, MAPT, SNCA
4cytosolGO:0058299.8CDK5, STUB1, RPS27A, CAMK2G, HTT, NPEPPS

Biological processes related to Tauopathy according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1dopamine uptake involved in synaptic transmissionGO:05158310.7PARK7, SNCA
2regulation of locomotionGO:04001210.7SNCA, LRRK2
3negative regulation of neuron apoptotic processGO:04352410.7PARK7, SNCA, PSEN1, HTT
4neuron apoptotic processGO:05140210.6HTT, PSEN1, CDK5
5regulation of synaptic plasticityGO:04816710.6HTT, PSEN1, CDK5
6positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:03243610.6LRRK2, STUB1, PSEN1
7peptidyl-threonine phosphorylationGO:01810710.6MAPK8, CDK5, LRRK2
8positive regulation of receptor recyclingGO:00192110.6SNCA, PSEN1
9autophagyGO:00691410.6NPC1, LRRK2, PARK7
10axon cargo transportGO:00808810.6MAPT, HTT
11peptidyl-serine phosphorylationGO:01810510.6LRRK2, CDK5, MAPK8
12behavioral response to cocaineGO:04814810.5CDK5, SNCA
13determination of adult lifespanGO:00834010.5HTT, LRRK2
14positive regulation of apoptotic processGO:04306510.4RPS27A, PSEN1, PPP2R4, MAPK8
15synaptic vesicle endocytosisGO:04848810.4CDK5, SNCA
16protein polyubiquitinationGO:00020910.3STUB1, NPEPPS, RPS27A
17neuron migrationGO:00176410.3PSEN1, MAPT, CDK5
18axon extensionGO:04867510.1CDK5, MAPT

Molecular functions related to Tauopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Hsp70 protein bindingGO:03054410.4SNCA, STUB1
2protein bindingGO:0055159.6PARK7, CAMK2G, HTT, NPC1, PSEN1, STUB1

Products for genes affiliated with Tauopathy

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Sources for Tauopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet