GCA
MCID: TMP003
MIFTS: 60

Temporal Arteritis (GCA) malady

Categories: Rare diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases, Neuronal diseases, Muscle diseases, Oral diseases

Aliases & Classifications for Temporal Arteritis

About this section
Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 38MedlinePlus, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 49NINDS, 50Novoseek, 52OMIM, 54Orphanet, 62SNOMED-CT, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Temporal Arteritis:

Name: Temporal Arteritis 52 11 48 49 54 13 68
Giant Cell Arteritis 11 48 49 54 38 39 13 68
Polymyalgia Rheumatica 11 54 50 38 39 13 68
Cranial Arteritis 48 49 68
Rhizomelic Pseudopolyarthritis 54 68
Horton's Giant Cell Arteritis 48
Horton's Temporal Arteritis 48
Giant Cell Arteritis Nos 11
 
Arteritis Temporalis 48
Horton’s Syndrome 48
Arteritis Cranialis 48
Horton's Arteritis 48
Horton’s Disease 48
Horton's Disease 11
Horton Disease 54
Gca 48

Characteristics:

Orphanet epidemiological data:

54
giant cell arteritis:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000 (Germany),1-5/10000 (United Kingdom),1-5/10000 (Europe); Age of onset: Adult; Age of death: normal life expectancy

HPO:

64
temporal arteritis:
Inheritance: autosomal dominant inheritance

Classifications:



External Ids:

OMIM52 187360
Disease Ontology11 DOID:13375, DOID:853
ICD9CM32 446.5, 725
ICD1030 M35.3, M31.5
ICD10 via Orphanet31 M31.6, M35.3
MESH via Orphanet40 D013700
UMLS via Orphanet69 C0039483, C1956391, C1527406

Summaries for Temporal Arteritis

About this section
NINDS:49 Vasculitis is an inflammation of blood vessels, which includes the veins, arteries, and capillaries. Inflammation occurs with infection or is thought to be due to a faulty immune system response. It also can be caused by other immune system disease, an allergic reaction to medicines or toxins, and by certain blood cancers. Vasculitic disorders can cause problems in any organ system, including the central (CNS) and peripheral (PNS) nervous systems. Vasculitis disorders, or syndromes, of the CNS and PNS are characterized by the presence of inflammatory cells in and around blood vessels, and secondary narrowing or blockage of the blood vessels that nourish the brain, spinal cord, or peripheral nerves. A vasculitic syndrome may begin suddenly or develop over time. Symptoms include headaches, especially a headache that doesn’t go away; fever, rapid weight loss; confusion or forgetfulness leading to dementia; swelling of the brain, pain while chewing or swallowing; paralysis or numbness, usually in the arms or legs; and visual disturbances, such as double vision, blurred vision, or blindness Some of the better understood vasculitis syndromes are temporal arteritis (also called giant cell arteritis or cranial arteritis--a chronic inflammatory disorder of large blood vessels) and Takayasu’s disease, which affects larger aortas and may cause stoke.

MalaCards based summary: Temporal Arteritis, also known as giant cell arteritis, is related to ischemic optic neuropathy and hepatitis, and has symptoms including back pain, exanthema and muscle cramp. An important gene associated with Temporal Arteritis is CRP (C-Reactive Protein), and among its related pathways are Overview of nanoparticle effects and Immune response_Oncostatin M signaling via JAK-Stat in human cells. Affiliated tissues include testes, tongue and skin, and related mouse phenotype immune system.

NIH Rare Diseases:48 Giant cell arteritis (gca) is a form of vasculitis, a group of disorders that cause inflammation of blood vessels. in gca, the vessels of the head are most involved (especially the temporal arteries, located on each side of the head), but other blood vessels can also become inflamed. the inflammation causes the arteries to narrow, resulting in poor blood flow. signs and symptoms may include a throbbing headache on one side of the head or the back of the head; tenderness of the scalp; various symptoms that feel like the flu; and/or problems with eyesight. the cause of gca is still being studied, but an abnormal immune response has been implicated. several genetic and environmental factors may increase a person's risk to develop gca. early treatment is important and may include corticosteroids and/or other medications that suppress the immune system. last updated: 4/5/2016

MedlinePlus:38 Giant cell arteritis is a disorder that causes inflammation of your arteries, usually in the scalp, neck, and arms. it narrows the arteries, which keeps blood from flowing well. giant cell arteritis often occurs with another disorder called polymyalgia rheumatica. both are more common in women than in men. they almost always affect people over the age of 50. early symptoms of giant cell arteritis resemble the flu: fatigue, loss of appetite, and fever. other symptoms include headaches pain and tenderness over the temples double vision or visual loss, dizziness problems with coordination and balance pain in your jaw and tongue your doctor will make the diagnosis based on your medical history, symptoms, and a physical exam. there is no single test to diagnose giant cell arteritis, but you may have tests that measure inflammation. treatment is usually with corticosteroids. early treatment is important; otherwise there is a risk of permanent vision loss or stroke. however, when properly treated, giant cell arteritis rarely comes back. nih: national institute of arthritis and musculoskeletal and skin diseases

Wikipedia:71 Giant-cell arteritis (GCA), also called temporal arteritis, cranial arteritis, or Horton disease is an... more...

Description from OMIM:52 187360

Related Diseases for Temporal Arteritis

About this section

Diseases in the Temporal Arteritis family:

Juvenile Temporal Arteritis

Diseases related to Temporal Arteritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 271)
idRelated DiseaseScoreTop Affiliating Genes
1ischemic optic neuropathy29.8APOH, CRP, IL6
2hepatitis29.8HLA-DRB1, IFNG, IL6
3myeloid leukemia29.7APOH, CD40LG
4atherosclerosis29.4APOH, IL6
5asbestosis29.4APOH, CRP, IL6
6retinal ischemia29.4CCL2, CCL5, IFNG
7choroiditis29.3CCL2, CRP, IL6
8rheumatoid arthritis28.4CCL2, CCL5, CD40LG, CRP, HLA-DRB1, IFNG
9juvenile temporal arteritis12.5
10rhizomelic pseudopolyarthritis12.2
11arteritic anterior ischemic optic neuropathy11.6
12retinal vasculitis11.3
13nonarteritic anterior ischemic optic neuropathy11.1
14vasculitis syndromes of the central and peripheral nervous systems10.9
15exhibitionism10.3APOH, CD40LG
16polycythemia due to hypoxia10.3CD40LG, CRP
17intermediate coronary syndrome10.3APOH, CD40LG
18lubinsky syndrome10.3APOH, CD40LG
19hordeolum10.3CD40LG, SMUG1
20cannabis dependence10.3CD40LG, CRP
21non-amyloid monoclonal immunoglobulin deposition disease10.3HLA-DRB1, PTPN22
22adrenal gland ganglioneuroblastoma10.3CD40LG, TNFRSF10A
23caplan's syndrome10.3HLA-DRB1, IFNG
24complement component 8 deficiency10.2HLA-DRB1, PTPN22
25distal trisomy 14q10.2HLA-DRB1, IFNG
26haemonchiasis10.2APOH, CD40LG, CRP
27benign deep fibrous histiocytoma10.2CD40LG, HLA-DRB1, IFNG
28testicular lymphoma10.2CD40LG, CRP, IFNG
29pseudohypoparathyroidism10.2APOH, CD40LG, HLA-DRB1
30artery disease10.2CD40LG, CRP, SMUG1
31heart conduction disease10.2CD40LG, HLA-DRB1, IFNG
32hypertropia10.2CRP, IFNG, SMUG1
33coloboma of iris10.2CRP, IL6
34sclerosing breast papilloma10.2CD40LG, SMUG1
35generalized dystonia10.2CD40LG, CRP, IL1RN
36autoimmune disease of skin and connective tissue10.2CD40LG, IFNG, TNFRSF10A
37molybdenum cofactor deficiency a10.1CRP, HLA-DRB1, PTPN22
38strawberry gallbladder10.1CCL2, CRP, IFNG
39janus kinase-3 deficiency10.1IFNG, PTPN22, TNFRSF10A
40pulsating exophthalmos10.1HLA-DRB1, IFNG, PTPN22
41celiac disease10.1CD40LG, CRP, IL1RN
42supraumbilical midabdominal raphe and facial cavernous hemangiomas10.1APOH, IL6
43proximal symphalangism10.1CCL2, CD40LG, IFNG
44endobronchial leiomyoma10.1CD40LG, CRP, IL1RN
45retinal degeneration10.1CD40LG, CRP, IL6
46unilateral multicystic dysplastic kidney10.1CRP, IL6
47cataract, total congenital10.1CRP, IFNG, IL6
48hemangioma of spleen10.1CRP, IFNG, IL6
49female breast upper-inner quadrant cancer10.1CRP, SMUG1, TNFRSF10A
50multiple mitochondrial dysfunctions syndrome10.1CRP, IFNG, IL6

Comorbidity relations with Temporal Arteritis via Phenotypic Disease Network (PDN):

(show all 24)
Rheumatoid ArthritisHypertension, Essential
OsteoporosisPituitary Adenoma, Acth-Secreting
Nonarteritic Anterior Ischemic Optic NeuropathyDeficiency Anemia
Chronic Myocardial IschemiaIschemic Heart Disease
Familial Atrial FibrillationAdrenal Cortical Hypofunction
Cerebral ArteritisHeart Disease
Iron Deficiency AnemiaEsophagitis
Optic NeuritisAcute Cystitis
HypothyroidismTransient Cerebral Ischemia
Mitral Valve DiseaseBronchitis
Active Peptic Ulcer DiseaseIntermediate Coronary Syndrome
PolymyositisLeft Ventricular Outflow Tract Obstruction

Graphical network of the top 20 diseases related to Temporal Arteritis:



Diseases related to temporal arteritis

Symptoms & Phenotypes for Temporal Arteritis

About this section

Symptoms by clinical synopsis from OMIM:

187360

Clinical features from OMIM:

187360

Human phenotypes related to Temporal Arteritis:

 54 64 (show all 57)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency64 54 Occasional (29-5%) HP:0000083
2 glossitis64 54 Occasional (29-5%) HP:0000206
3 hearing impairment54 Occasional (29-5%)
4 conductive hearing impairment64 54 Occasional (29-5%) HP:0000405
5 epistaxis64 54 Occasional (29-5%) HP:0000421
6 visual impairment64 54 Frequent (79-30%) HP:0000505
7 ptosis64 54 Occasional (29-5%) HP:0000508
8 visual loss64 54 Occasional (29-5%) HP:0000572
9 ophthalmoparesis64 54 Frequent (79-30%) HP:0000597
10 nystagmus64 54 Occasional (29-5%) HP:0000639
11 optic atrophy64 54 Occasional (29-5%) HP:0000648
12 diplopia64 54 Occasional (29-5%) HP:0000651
13 depression64 54 Frequent (79-30%) HP:0000716
14 hematuria64 54 Occasional (29-5%) HP:0000790
15 diabetes insipidus64 54 Occasional (29-5%) HP:0000873
16 hyperhidrosis64 54 Occasional (29-5%) HP:0000975
17 visual field defect64 54 Occasional (29-5%) HP:0001123
18 ataxia64 54 Occasional (29-5%) HP:0001251
19 meningitis64 54 Occasional (29-5%) HP:0001287
20 muscle weakness64 54 Occasional (29-5%) HP:0001324
21 arthritis64 54 Frequent (79-30%) HP:0001369
22 joint stiffness64 54 Very frequent (99-80%) HP:0001387
23 hepatic failure64 54 Occasional (29-5%) HP:0001399
24 alopecia64 54 Frequent (79-30%) HP:0001596
25 sudden cardiac death64 54 Occasional (29-5%) HP:0001645
26 pericarditis64 54 Occasional (29-5%) HP:0001701
27 weight loss64 54 Very frequent (99-80%) HP:0001824
28 abnormality of thrombocytes64 54 Occasional (29-5%) HP:0001872
29 fever64 54 Very frequent (99-80%) HP:0001945
30 abdominal pain64 54 Occasional (29-5%) HP:0002027
31 anorexia64 54 Very frequent (99-80%) HP:0002039
32 abnormality of the pleura64 54 Occasional (29-5%) HP:0002103
33 headache64 54 Very frequent (99-80%) HP:0002315
34 vertigo64 54 Occasional (29-5%) HP:0002321
35 vasculitis64 54 Very frequent (99-80%) HP:0002633
36 cerebral ischemia64 54 Very frequent (99-80%) HP:0002637
37 aortic dissection64 54 Occasional (29-5%) HP:0002647
38 arthralgia64 54 Occasional (29-5%) HP:0002829
39 myalgia64 54 Occasional (29-5%) HP:0003326
40 paresthesia64 54 Occasional (29-5%) HP:0003401
41 elevated erythrocyte sedimentation rate64 54 Frequent (79-30%) HP:0003565
42 arterial thrombosis64 54 Occasional (29-5%) HP:0004420
43 abdominal aortic aneurysm64 54 Occasional (29-5%) HP:0004953
44 chewing difficulties64 54 Very frequent (99-80%) HP:0005216
45 gastrointestinal infarctions64 54 Occasional (29-5%) HP:0005244
46 peripheral neuropathy54 Occasional (29-5%)
47 double outlet right ventricle with subpulmonary ventricular septal defect without pulmonary stenosis64 54 Occasional (29-5%) HP:0011658
48 arrhythmia54 Occasional (29-5%)
49 fatigue64 54 Very frequent (99-80%) HP:0012378
50 cough64 54 Occasional (29-5%) HP:0012735
51 amaurosis fugax64 54 Occasional (29-5%) HP:0100576
52 mediastinal lymphadenopathy64 54 Occasional (29-5%) HP:0100721
53 gangrene64 54 Occasional (29-5%) HP:0100758
54 recurrent pharyngitis64 54 Occasional (29-5%) HP:0100776
55 skin ulcer64 54 Occasional (29-5%) HP:0200042
56 blindness64 HP:0000618
57 retinal arteritis64 HP:0008030

UMLS symptoms related to Temporal Arteritis:


back pain, exanthema, muscle cramp, muscle rigidity, muscle spasticity, pruritus, sciatica, muscle weakness, myalgia, angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Temporal Arteritis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053876.4CCL2, CCL5, CD40LG, CRP, IFNG, IL1RN

Drugs & Therapeutics for Temporal Arteritis

About this section

Drugs for Temporal Arteritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 93)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Prednisoneapproved, vet_approvedPhase 4, Phase 2, Phase 3, Phase 1139853-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
 
Juvason
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
2Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 2, Phase 3, Phase 113168
3HormonesPhase 4, Phase 2, Phase 3, Phase 114415
4Anti-Inflammatory AgentsPhase 4, Phase 3, Phase 2, Phase 110729
5Hormone AntagonistsPhase 4, Phase 2, Phase 3, Phase 113180
6Antineoplastic Agents, HormonalPhase 4, Phase 2, Phase 3, Phase 15592
7glucocorticoidsPhase 4, Phase 2, Phase 3, Phase 15103
8Omega 3 Fatty AcidNutraceuticalPhase 41018
9
InfliximabapprovedPhase 3, Phase 2392170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
10
Prednisoloneapproved, vet_approvedPhase 2, Phase 3119350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
11
Methylprednisoloneapproved, vet_approvedPhase 2, Phase 3119383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
12
HydroxychloroquineapprovedPhase 3154118-42-33652
Synonyms:
(+-)-Hydroxychloroquine
(±)-hydroxychloroquine
118-42-3
2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol
2-((4-((7-chloro-4-Quinolyl)amino)pentyl)ethylamino)ethanol
2-(N-(4-(7-Chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol
2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol
2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol
5-22-10-00280 (Beilstein Handbook Reference)
7-Chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline
7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline
7-Chloro-4-(5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl)aminoquinoline
7-chloro-4-(4-(Ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline
7-chloro-4-(4-(N-Ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline
7-chloro-4-[4-(N-Ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline
7-chloro-4-[5-(N-Ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline
747-36-4 (sulfate (1:1) salt)
AC1L1GEW
BRN 0253894
C07043
C18H26ClN3O
CHEMBL1535
CID3652
D08050
DB01611
DivK1c_000942
EINECS 204-249-8
Gen-Hydroxychloroquine 200mg Tablets
HCQ
HMS502P04
Hidroxicloroquina
 
Hidroxicloroquina [INN-Spanish]
Hydroxychlorochin
Hydroxychloroguine
Hydroxychloroquine (INN)
Hydroxychloroquine Sulfate (1:1) Salt
Hydroxychloroquine [INN:BAN]
Hydroxychloroquinum
Hydroxychloroquinum [INN-Latin]
IDI1_000942
Idrossiclorochina
Idrossiclorochina [DCIT]
KBio1_000942
LS-66614
MolPort-003-847-792
NCGC00159483-02
NINDS_000942
NSC4375
Oxichlorochine
Oxichlorochinum
Oxichloroquine
Oxychlorochin
Oxychloroquine
PlaqueN/A
Polirreumin
Polirreumin (TN)
Quensyl
SPBio_001116
ST072188
Spectrum2_001238
Spectrum5_001697
UNII-4QWG6N8QKH
WIN 1258
hydroxychloroquine
13
Etanerceptapproved, investigationalPhase 3403185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
14
MethotrexateapprovedPhase 3, Phase 215511959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
15
AdalimumabapprovedPhase 3494331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
16
AlendronateapprovedPhase 3162121268-17-5, 66376-36-12088
Synonyms:
(4-Amino-1-hydroxybutylidene)bisphosphonic acid
(4-Amino-1-hydroxybutylidene)diphosphonic acid
(4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid
(4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid)
(4-amino-1-hydroxybutylidene)bisphosphonic acid
121268-17-5 (mono-hydrochloride salt, trihydrate)
1yhm
4-Amino-1-hydroxybutane-1,1-diphosphonate
4-Amino-1-hydroxybutane-1,1-diphosphonic Acid
4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid)
4-Amino-1-hydroxybutylidene-1,1-bisphosphonate
4-amino-1-hydroxybutane-1,1-diphosphonic acid
66376-36-1
ABDP
AC1L1CW3
AKOS001015793
ALENDRONATE SODIUM
ALENDRONIC ACID
Acide Alendronique
Acide Alendronique [INN-French]
Acide alendronique
Acide alendronique [INN-French]
Acido Alendronico
Acido Alendronico [INN-Spanish]
Acido alendronico
Acido alendronico [INN-Spanish]
Acidum Alendronicum
Acidum Alendronicum [INN-Latin]
Acidum alendronicum
Acidum alendronicum [INN-Latin]
Adronat
 
Alendronate
Alendronate Sodium
Alendronate sodium hydrate
Alendronic acid
Alendronic acid (INN)
Alendronic acid [INN:BAN]
Alendros
Arendal
BIDD:GT0180
C07752
CHEBI:2567
CHEMBL870
CID2088
D07119
DB00630
Fosamax
Fosamax Plus D
HSCI1_000337
LS-106421
MK 217
MK-217
MolPort-000-421-410
NCGC00096054-01
NCGC00096054-03
NCGC00096054-04
Onclast
Oprea1_422906
Phosphonic acid, (4-amino-1-hydroxybutylidene)bis
SPECTRUM1505166
ST50036159
UNII-X1J18R4W8P
alendronate
bisphosphonate, 65
17
Folic Acidapproved, nutraceutical, vet_approvedPhase 3, Phase 2439259-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
18
leucovorinapproved, NutraceuticalPhase 3, Phase 2323558-05-954575, 6560146, 143
Synonyms:
(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
(6R,S)-5-Formyltetrahydrofolate
10-Formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolate
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
5-Formyltetrahydrofolate
5-Formyltetrahydrofolic acid
5-Formyltetrahydropteroylglutamate
5-Formyltetrahydropteroylglutamic acid
5-formyltetrahydrofolic acid
Acide folinique
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinate
Folinic acid
Folinic acid calcium salt
 
Folinic acid calcium salt USP27
Folinic acid-SF
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
L-Leucovorin
L-N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
L-leucovorin
Leucal
Leucovorin calcium
Leucovorin folinic acid
Leucovorinum
Leukovorin
Levoleucovorin
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
N5-Formyl-THF
N5-Formyltetrahydrofolate
N5-Formyltetrahydrofolic acid
Welcovorin
Wellcovorin
folinate
19
Alfacalcidolapproved, nutraceuticalPhase 36141294-56-85282181
Synonyms:
(5Z,7e)-9,10-Seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol
1-Hydroxycholecalciferol
1-hydroxycholecalciferol
1alpha-Hydroxy-vitamin D3
 
1alpha-hydroxycholecalciferol
1alpha-hydroxyvitamin D3
9,10-Secocholesta-5,7,10(19)-triene-1alpha,3beta-diol
Alfacalcidolum
Alsiodol
20Neuroprotective AgentsPhase 2, Phase 31716
21Pharmaceutical SolutionsPhase 38192
22Methylprednisolone HemisuccinatePhase 2, Phase 31193
23Protective AgentsPhase 2, Phase 37443
24Methylprednisolone acetatePhase 2, Phase 31193
25Prednisolone acetatePhase 2, Phase 31193
26Prednisolone phosphatePhase 2, Phase 31193
27Prednisolone hemisuccinatePhase 2, Phase 31193
28Immunosuppressive AgentsPhase 3, Phase 2, Phase 113086
29Autonomic AgentsPhase 2, Phase 310150
30Anti-Infective AgentsPhase 322062
31Gastrointestinal AgentsPhase 3, Phase 28402
32Dermatologic AgentsPhase 3, Phase 2, Phase 15806
33Antirheumatic AgentsPhase 3, Phase 210956
34AntiemeticsPhase 2, Phase 34022
35Peripheral Nervous System AgentsPhase 3, Phase 223689
36VitaminsPhase 35282
37AntimetabolitesPhase 3, Phase 212054
38Vitamin B ComplexPhase 3, Phase 24337
39vitamin dPhase 31724
40Folic Acid AntagonistsPhase 3, Phase 22257
41Nucleic Acid Synthesis InhibitorsPhase 3, Phase 24962
42Antimetabolites, AntineoplasticPhase 3, Phase 27361
43Antiprotozoal AgentsPhase 32051
44Antiparasitic AgentsPhase 32199
45AntimalarialsPhase 31246
46Trace ElementsPhase 36001
47AnalgesicsPhase 311733
48Analgesics, Non-NarcoticPhase 36501
49MicronutrientsPhase 36001
50HydroxycholecalciferolsPhase 3129

Interventional clinical trials:

(show top 50)    (show all 62)
idNameStatusNCT IDPhase
1Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell ArteritisUnknown statusNCT01400464Phase 4
2Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica PatientsCompletedNCT01169597Phase 4
3Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein LevelsTerminatedNCT00578578Phase 4
4Infliximab Therapy in Patients With Refractory Polymyalgia RheumaticaUnknown statusNCT01423591Phase 3
5Hydroxychloroquine in Giant Cell ArteritisCompletedNCT00430807Phase 3
6HECTHOR: Humira to Spare Steroids in Giant Cell ArteritisCompletedNCT00305539Phase 3
7Etanercept Treatment in the Early Course of Polymyalgia RheumaticaCompletedNCT00524381Phase 3
8Timed Release Tablet Prednisone in Polymyalgia RheumaticaCompletedNCT00836810Phase 2, Phase 3
9Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol.CompletedNCT00138983Phase 3
10Efficacy and Safety Study of Sirukumab in Patients With Giant Cell ArteritisRecruitingNCT02531633Phase 3
11Safety and Efficacy of tocilizuMAb Versus Placebo in Polymyalgia rHeumatica With glucocORticoid dEpendence SEMAPHORERecruitingNCT02908217Phase 3
12An Efficacy and Safety Study of Tocilizumab (RoActemra/Actemra) in Participants With Giant Cell Arteritis (GCA)Active, not recruitingNCT01791153Phase 3
13Giant Cell Arteritis and Anakinra TrialNot yet recruitingNCT02902731Phase 3
14Efficacy and Safety Study of Sirukumab in Subjects With Polymyalgia RheumaticaNot yet recruitingNCT02899026Phase 3
15A Study Assessing the Efficacy and Safety of Lodotra® Compared to Prednisone IR in Subjects Suffering From PMRTerminatedNCT01821040Phase 3
16Evaluation of Tocilizumab as an add-on Therapy to Corticoids in Horton's Disease: Proof of Concept Study.Unknown statusNCT01910038Phase 2
17Tocilizumab for Patients With Giant Cell ArteritisCompletedNCT01450137Phase 2
18Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's ArteritisCompletedNCT00556439Phase 2
19Phase II Randomized Study of Glucocorticoids With or Without Methotrexate for Treatment of Giant Cell ArteritisCompletedNCT00004686Phase 2
20Study of Tocilizumab to Treat Polymyalgia RheumaticaCompletedNCT01396317Phase 2
21Tocilizumab Effect iN pOlymyalgia RheumaticaCompletedNCT01713842Phase 2
22Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat UveitisCompletedNCT01789320Phase 1, Phase 2
23Ustekinumab for the Treatment of Giant Cell ArteritisRecruitingNCT02955147Phase 1, Phase 2
24Baricitinib in Relapsing Giant Cell ArteritisRecruitingNCT03026504Phase 2
25A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Giant Cell ArteritisTerminatedNCT00076726Phase 2
26A 3-arm Proof of Concept Study of AIN457, ACZ885 or Corticosteroids in Patients With Polymyalgia RheumaticaTerminatedNCT01364389Phase 2
27Delayed Release Prednisone in PMRTerminatedNCT02702778Phase 2
28MRI Superficial Temporal ArteryCompletedNCT00188448Phase 1
29Efficacy of Micro-Pulse Steroid Therapy as Induction Therapy in Patients With Polymyalgia RheumaticaUnknown statusNCT00982332
30Study of the T CD8 Immune Response in Horton's DiseaseUnknown statusNCT02158208
31Diagnostic Study of Temporal ArteritisUnknown statusNCT01130857
32Quantitative and Functional Study of TH17 Lymphocytes in Horton's Disease (HD)Unknown statusNCT02065297
33Sensitivity and Specificity of Color Doppler Directed Temporal Artery Biopsy as Compared to Standard Random Biopsy in the Diagnosis of Temporal ArteritisUnknown statusNCT00361192Early Phase 1
34Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune DiseasesUnknown statusNCT00006055
35Carotid Artery Neovascularization in Takayasu's and Giant Cell ArteritisCompletedNCT01795456
36Temporal Artery Biopsy vs ULtrasound in Diagnosis of GCA (TABUL)CompletedNCT00974883
37Lymphocyte and Cytokine Disturbances in Polymyalgia RheumaticaCompletedNCT02888496
38Educational Needs of Patients With Systemic VasculitisCompletedNCT02190929
39Reproductive Health in Men and Women With VasculitisCompletedNCT02176070
40Vasculitis Illness Perception (VIP) StudyCompletedNCT02190916
41Impact of Vasculitis on Employment and IncomeCompletedNCT02476292
42Magnetic Resonance Angiography vs Ultrasonography in Systemic Large vEssel vasculitiSCompletedNCT02042092
43Determining Disease Activity Biomarkers in Individuals With Giant Cell ArteritisRecruitingNCT00315497
44Biomarkers in Giant Cells ArteritisRecruitingNCT02844023
45Prospective Follow-up Study of the Aortic Diameter in Patients With Giant Cell ArteritisRecruitingNCT01588483
46Study of Circulating Microparticles in Giant Cell ArteritisRecruitingNCT02333708
47Study of Phenotypic and Functional Characteristics of Regulatory T Lymphocytes in Horton's DiseaseRecruitingNCT02857192
48Validation of a Diagnostic Algorithm of Giant Cell ArteritisRecruitingNCT02703922
49Improving the Diagnosis and Prognostication of GCA Through the Novel Use of PET Scan and Immune BiomarkersRecruitingNCT02771483
50Interest of Medical Imaging in the Diagnostic Strategy Vis a Vis a Suspected Horton DiseaseRecruitingNCT02473029

Search NIH Clinical Center for Temporal Arteritis


Cochrane evidence based reviews: polymyalgia rheumatica

Genetic Tests for Temporal Arteritis

About this section

Anatomical Context for Temporal Arteritis

About this section

MalaCards organs/tissues related to Temporal Arteritis:

36
Testes, Tongue, Skin, Brain, Spinal cord, Bone, Endothelial

Publications for Temporal Arteritis

About this section

Articles related to Temporal Arteritis:

(show top 50)    (show all 538)
idTitleAuthorsYear
1
Studies on the Histopathology of Temporal Arteritis. (28275606)
2017
2
Metaplastic ossification of the temporal artery with osteoclast-like giant cells: a mimicker of giant cell (temporal) arteritis. (28315516)
2017
3
Hypertrophic Pachymeningitis as a Potential Cause of Headache Associated with Temporal Arteritis. (26935376)
2016
4
When a temporal artery biopsy reveals a diagnosis other than temporal arteritis: eosinophilic granulomatosis with polyangiitis. (27316282)
2016
5
Temporal Arteritis With Arteritic Anterior Ischemic Optic Neuropathy is Bilateral Until Proven Otherwise: Response. (27855129)
2016
6
The Temporal Arteritis Proforma: Should cough be included? (27592336)
2016
7
Bilateral Blindness in a Patient With Temporal Arteritis After Wisdom Tooth Extraction. (26854772)
2016
8
VZV, temporal arteritis, and clinical practice: False positive immunohistochemical detection due to antibody cross-reactivity. (26688577)
2016
9
Juvenile temporal arteritis with eosinophilia associated with systemic sclerosis. (27401371)
2016
10
Is All Inflammation within Temporal Artery Biopsies Temporal Arteritis? (27445262)
2016
11
Preserved Visual Acuity in Anterior Ischemic Optic Neuropathy Secondary to Giant Cell (temporal) Arteritis. (26958148)
2016
12
Temporal arteritis with erythrocyte sedimentation rate <50 mm/h: a clinical reminder. (26966355)
2016
13
Extracranial cutaneous manifestation of temporal arteritis--a case of erythematous plaques on the legs. (26713645)
2016
14
Annular Elastolytic Giant Cell Granuloma and Temporal Arteritis Following Herpes Zoster. (26861435)
2015
15
Waldenstrom Macroglobulinemia Mimicking Temporal Arteritis. (25996301)
2015
16
The effect of temporal artery biopsy on the treatment of temporal arteritis. (25457237)
2015
17
A case of temporal arteritis in Filippino Lippi's (1459-1504) Saint Frediano? (26638160)
2015
18
Elderly woman with headache. Giant cell arteritis/temporal arteritis. (25910765)
2015
19
Annular Elastolytic Giant Cell Granuloma and Temporal Arteritis Following Herpes Zoster. (26861422)
2015
20
Magnetic Resonance Imaging of Temporal Arteritis: A Case Report. (25758708)
2015
21
Giant cell arteritis (temporal arteritis) revisited. (26448217)
2015
22
Calciphylaxis of the temporal artery masquerading as temporal arteritis: a case presentation and review of the literature. (25903821)
2015
23
Giant Cell Arteritis of the Female Genital Tract With Occult Temporal Arteritis and Marginal Zone Lymphoma Harboring Novel 20q Deletion: A Case Report and Literature Review. (26353853)
2015
24
Monckeberg's Arteriosclerosis in Temporal Arteritis Suspect. (26711297)
2015
25
The role of ultrasound in the diagnosis of temporal arteritis. (25890932)
2015
26
Fatal Calciphylaxis Presenting as Polymyalgia Rheumatica and Temporal Arteritis. (26583498)
2015
27
Polyarteritis nodosa mimicking giant cell (temporal) arteritis. (25030583)
2014
28
Perivascular Marginal Zone Lymphoma Mimicking Temporal Arteritis. (25361636)
2014
29
High-resolution color-coded ultrasonography findings of subacute temporal arteritis with ulcerating skin lesions. (25047586)
2014
30
Primary systemic Al amyloidosis presenting as temporal arteritis. (24551471)
2014
31
A rare case of temporal arteritis with rheumatoid arthritis and interstitial lung disease mimicking pulpo-periodontal pathology. (25210275)
2014
32
Temporal Artery Calciphylaxis Presenting as Temporal Arteritis in a Case of Rhinoorbitocerebral Mucormycosis. (24853118)
2014
33
Temporal ultrasonography findings in temporal arteritis: early disappearance of halo sign after only 2 days of steroid treatment. (23300333)
2013
34
Amyloid deposits in temporal artery mimicking temporal arteritis in a patient with multiple myeloma. (24232087)
2013
35
Vertebrobasilar Infarction Related to Giant Cell (Temporal) Arteritis: Case Report. (24390182)
2013
36
Morphological features of temporal arteritis. (23543964)
2013
37
Juvenile temporal arteritis. (23294490)
2013
38
Scalp necrosis in temporal arteritis: abrupt termination of the superficial temporal artery as a possible precursor. (23331479)
2013
39
Temporal arteritis in a young patient. (24143876)
2013
40
Methotrexate in refractory bilateral juvenile temporal arteritis: Report of a case. (24252028)
2013
41
Stellate ganglion block as an early intervention in sympathetically maintained headache and orofacial pain caused by temporal arteritis. (23332006)
2013
42
Temporal arteritis in the young. (23142255)
2013
43
Temporal arteritis: improving patient evaluation with a new protocol. (23596371)
2013
44
The activation pattern of macrophages in giant cell (temporal) arteritis and primary angiitis of the central nervous system. (24354510)
2013
45
The role of ultrasound biomicroscopy in the diagnosis of temporal arteritis. (23431722)
2012
46
Headache and temporal arteritis: when to suspect and how to manage. (22552735)
2012
47
Giant cell temporal arteritis associated with overlying basal cell carcinoma: co-incidence or connection? (23087802)
2012
48
TEMPL3: a simple mnemonic for the diagnosis of temporal arteritis. (23577360)
2012
49
Temporal arteritis: A case series from south India and an update of the Indian scenario. (22412269)
2012
50
Steroid-induced sigmoid diverticular perforation in a patient with temporal arteritis: a rare clinical pathology. (22493565)
2012

Variations for Temporal Arteritis

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Expression for genes affiliated with Temporal Arteritis

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Search GEO for disease gene expression data for Temporal Arteritis.

Pathways for genes affiliated with Temporal Arteritis

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Pathways related to Temporal Arteritis according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathwaysScoreTop Affiliating Genes
19.6CRP, IL6
29.6CCL2, SERPINA3
39.2HLA-DRB1, IFNG, IL6
4
Show member pathways
9.2CD40LG, IFNG, IL6
59.0CCL2, IFNG, IL6
68.7CCL2, CD40LG, IFNG, IL6
78.5CCL2, CCL5, IL6
88.5CCL2, CCL5, IL6
98.2CCL2, CCL5, CD40LG, IL6
108.0CCL2, CCL5, IL1RN, IL6
117.9CCL2, CCL5, HLA-DRB1, IFNG, IL6
127.7CCL2, CCL5, CD40LG, IFNG, IL1RN, PTPN22
13
Show member pathways
7.6CCL2, CCL5, CRP, IFNG, IL6, SERPINA3
14
Show member pathways
7.5CCL2, CCL5, CD40LG, IL6, PTPN22, TNFRSF10A
15
Show member pathways
7.4CCL2, CCL5, HLA-DRB1, IFNG, IL6, TNFRSF10A
16
Show member pathways
7.1CCL2, CCL5, CD40LG, HLA-DRB1, IFNG, IL1RN
17
Show member pathways
6.2CCL2, CCL5, CD40LG, CRP, HLA-DRB1, IFNG

GO Terms for genes affiliated with Temporal Arteritis

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Cellular components related to Temporal Arteritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.7CD40LG, HLA-DRB1, IFNG, IL6
2extracellular regionGO:00055767.1APOH, CCL2, CCL5, CD40LG, CRP, IFNG
3extracellular spaceGO:00056156.4APOH, CCL2, CCL5, CD40LG, CRP, IFNG

Biological processes related to Temporal Arteritis according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:001088810.3CRP, IL6
2defense response to protozoanGO:004283210.3IFNG, IL6
3neutrophil apoptotic processGO:000178110.2IFNG, IL6
4positive regulation of protein import into nucleus, translocationGO:003316010.2IFNG, IL6
5negative regulation of interleukin-1-mediated signaling pathwayGO:200066010.0IL1RN, IL6
6acute-phase responseGO:000695310.0CRP, IL6, SERPINA3
7regulation of vascular endothelial growth factor productionGO:001057410.0CCL2, IL6
8macrophage chemotaxisGO:00482469.8CCL2, CCL5
9positive regulation of macrophage chemotaxisGO:00107599.8CCL2, CCL5
10positive regulation of monocyte chemotaxisGO:00900269.8CCL2, CCL5
11cellular response to lipopolysaccharideGO:00712229.8CCL2, IFNG, IL6
12humoral immune responseGO:00069599.8CCL2, IFNG, IL6
13positive regulation of JAK-STAT cascadeGO:00464279.7CCL5, IL6
14positive regulation of gene expressionGO:00106289.7CRP, IFNG, IL6, PTPN22
15T cell receptor signaling pathwayGO:00508529.6HLA-DRB1, IFNG, PTPN22
16lipopolysaccharide-mediated signaling pathwayGO:00316639.6CCL2, CCL5, PTPN22
17neutrophil chemotaxisGO:00305939.5CCL2, CCL5, IFNG
18positive regulation of cell adhesionGO:00457859.5CCL2, CCL5, IFNG
19response to glucocorticoidGO:00513849.4CCL2, IL1RN, IL6
20positive regulation of tyrosine phosphorylation of STAT proteinGO:00425319.4CCL5, IFNG, IL6
21cellular response to interleukin-1GO:00713479.3CCL2, CCL5, IL6
22cellular response to tumor necrosis factorGO:00713569.3CCL2, CCL5, IL6
23monocyte chemotaxisGO:00025489.2CCL2, CCL5, IL6
24response to lipopolysaccharideGO:00324969.2CCL2, IL6, PTPN22, TNFRSF10A
25positive regulation of T cell proliferationGO:00421029.1CCL5, CD40LG, IFNG, IL6
26positive regulation of ERK1 and ERK2 cascadeGO:00703748.9CCL2, CCL5, IL6, PTPN22
27immune responseGO:00069557.4CCL2, CCL5, CD40LG, HLA-DRB1, IFNG, IL1RN
28inflammatory responseGO:00069547.3CCL2, CCL5, CD40LG, CRP, IL1RN, IL6

Molecular functions related to Temporal Arteritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051257.4CCL2, CCL5, CD40LG, IFNG, IL1RN, IL6

Sources for Temporal Arteritis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet