GCA
MCID: TMP003
MIFTS: 60

Temporal Arteritis (GCA) malady

Categories: Rare diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases, Neuronal diseases, Muscle diseases, Oral diseases

Aliases & Classifications for Temporal Arteritis

Aliases & Descriptions for Temporal Arteritis:

Name: Temporal Arteritis 54 12 50 51 56 14 69
Giant Cell Arteritis 12 50 51 56 41 42 14 69
Polymyalgia Rheumatica 12 56 52 41 42 14 69
Cranial Arteritis 50 51 69
Rhizomelic Pseudopolyarthritis 56 69
Horton's Giant Cell Arteritis 50
Polymyalgia Rheumatica [dup] 12
Horton's Temporal Arteritis 50
Giant Cell Arteritis Nos 12
Arteritis Temporalis 50
Arteritis Cranialis 50
Horton's Arteritis 50
Horton’s Syndrome 50
Horton's Disease 12
Horton’s Disease 50
Horton Disease 56
Gca 50

Characteristics:

Orphanet epidemiological data:

56
giant cell arteritis
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000 (Germany),1-5/10000 (United Kingdom),1-5/10000 (Europe); Age of onset: Adult; Age of death: normal life expectancy;

HPO:

32
temporal arteritis:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 54 187360
Disease Ontology 12 DOID:13375 DOID:853
ICD9CM 35 446.5 725
ICD10 33 M35.3 M31.5
ICD10 via Orphanet 34 M31.6 M35.3
MESH via Orphanet 43 D013700
UMLS via Orphanet 70 C0039483 C1956391 C1527406

Summaries for Temporal Arteritis

NINDS : 51 Vasculitis is an inflammation of blood vessels, which includes the veins, arteries, and capillaries. Inflammation occurs with infection or is thought to be due to a faulty immune system response. It also can be caused by other immune system disease, an allergic reaction to medicines or toxins, and by certain blood cancers. Vasculitic disorders can cause problems in any organ system, including the central (CNS) and peripheral (PNS) nervous systems. Vasculitis disorders, or syndromes, of the CNS and PNS are characterized by the presence of inflammatory cells in and around blood vessels, and secondary narrowing or blockage of the blood vessels that nourish the brain, spinal cord, or peripheral nerves. A vasculitic syndrome may begin suddenly or develop over time. Symptoms include headaches, especially a headache that doesn’t go away; fever, rapid weight loss; confusion or forgetfulness leading to dementia; swelling of the brain, pain while chewing or swallowing; paralysis or numbness, usually in the arms or legs; and visual disturbances, such as double vision, blurred vision, or blindness Some of the better understood vasculitis syndromes are temporal arteritis (also called giant cell arteritis or cranial arteritis--a chronic inflammatory disorder of large blood vessels) and Takayasu’s disease, which affects larger aortas and may cause stoke.

MalaCards based summary : Temporal Arteritis, also known as giant cell arteritis, is related to ischemic optic neuropathy and hepatitis, and has symptoms including ataxia, arthralgia and fatigue. An important gene associated with Temporal Arteritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Prednisone and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, tongue and skin, and related phenotype is immune system.

NIH Rare Diseases : 50 giant cell arteritis (gca) is a form of vasculitis, a group of disorders that cause inflammation of blood vessels. in gca, the vessels of the head are most involved (especially the temporal arteries, located on each side of the head), but other blood vessels can also become inflamed. the inflammation causes the arteries to narrow, resulting in poor blood flow. signs and symptoms may include a throbbing headache on one side of the head or the back of the head; tenderness of the scalp; various symptoms that feel like the flu; and/or problems with eyesight. the cause of gca is still being studied, but an abnormal immune response has been implicated. several genetic and environmental factors may increase a person's risk to develop gca. early treatment is important and may include corticosteroids and/or other medications that suppress the immune system. last updated: 4/5/2016

MedlinePlus : 41 giant cell arteritis is a disorder that causes inflammation of your arteries, usually in the scalp, neck, and arms. it narrows the arteries, which keeps blood from flowing well. giant cell arteritis often occurs with another disorder called polymyalgia rheumatica. both are more common in women than in men. they almost always affect people over the age of 50. early symptoms of giant cell arteritis resemble the flu: fatigue, loss of appetite, and fever. other symptoms include headaches pain and tenderness over the temples double vision or visual loss, dizziness problems with coordination and balance pain in your jaw and tongue your doctor will make the diagnosis based on your medical history, symptoms, and a physical exam. there is no single test to diagnose giant cell arteritis, but you may have tests that measure inflammation. treatment is usually with corticosteroids. early treatment is important; otherwise there is a risk of permanent vision loss or stroke. however, when properly treated, giant cell arteritis rarely comes back. nih: national institute of arthritis and musculoskeletal and skin diseases

Wikipedia : 71 Giant-cell arteritis (GCA), also called temporal arteritis, cranial arteritis, or Horton disease is an... more...

Description from OMIM: 187360

Related Diseases for Temporal Arteritis

Diseases in the Temporal Arteritis family:

Juvenile Temporal Arteritis

Diseases related to Temporal Arteritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 271)
id Related Disease Score Top Affiliating Genes
1 ischemic optic neuropathy 29.8 APOH CRP IL6
2 hepatitis 29.8 HLA-DRB1 IFNG IL6
3 myeloid leukemia 29.7 APOH CD40LG
4 atherosclerosis 29.4 APOH IL6
5 asbestosis 29.4 APOH CRP IL6
6 retinal ischemia 29.4 CCL2 CCL5 IFNG
7 choroiditis 29.3 CCL2 CRP IL6
8 rheumatoid arthritis 28.4 CCL2 CCL5 CD40LG CRP HLA-DRB1 IFNG
9 juvenile temporal arteritis 12.5
10 rhizomelic pseudopolyarthritis 12.2
11 arteritic anterior ischemic optic neuropathy 11.6
12 retinal vasculitis 11.3
13 nonarteritic anterior ischemic optic neuropathy 11.1
14 vasculitis syndromes of the central and peripheral nervous systems 10.9
15 exhibitionism 10.3 APOH CD40LG
16 polycythemia due to hypoxia 10.3 CD40LG CRP
17 intermediate coronary syndrome 10.3 APOH CD40LG
18 lubinsky syndrome 10.3 APOH CD40LG
19 hordeolum 10.3 CD40LG SMUG1
20 cannabis dependence 10.3 CD40LG CRP
21 non-amyloid monoclonal immunoglobulin deposition disease 10.3 HLA-DRB1 PTPN22
22 adrenal gland ganglioneuroblastoma 10.3 CD40LG TNFRSF10A
23 caplan's syndrome 10.3 HLA-DRB1 IFNG
24 complement component 8 deficiency 10.2 HLA-DRB1 PTPN22
25 distal trisomy 14q 10.2 HLA-DRB1 IFNG
26 haemonchiasis 10.2 APOH CD40LG CRP
27 benign deep fibrous histiocytoma 10.2 CD40LG HLA-DRB1 IFNG
28 testicular lymphoma 10.2 CD40LG CRP IFNG
29 pseudohypoparathyroidism 10.2 APOH CD40LG HLA-DRB1
30 artery disease 10.2 CD40LG CRP SMUG1
31 heart conduction disease 10.2 CD40LG HLA-DRB1 IFNG
32 hypertropia 10.2 CRP IFNG SMUG1
33 coloboma of iris 10.2 CRP IL6
34 sclerosing breast papilloma 10.2 CD40LG SMUG1
35 generalized dystonia 10.2 CD40LG CRP IL1RN
36 autoimmune disease of skin and connective tissue 10.2 CD40LG IFNG TNFRSF10A
37 molybdenum cofactor deficiency a 10.1 CRP HLA-DRB1 PTPN22
38 strawberry gallbladder 10.1 CCL2 CRP IFNG
39 janus kinase-3 deficiency 10.1 IFNG PTPN22 TNFRSF10A
40 pulsating exophthalmos 10.1 HLA-DRB1 IFNG PTPN22
41 celiac disease 10.1 CD40LG CRP IL1RN
42 supraumbilical midabdominal raphe and facial cavernous hemangiomas 10.1 APOH IL6
43 proximal symphalangism 10.1 CCL2 CD40LG IFNG
44 endobronchial leiomyoma 10.1 CD40LG CRP IL1RN
45 retinal degeneration 10.1 CD40LG CRP IL6
46 unilateral multicystic dysplastic kidney 10.1 CRP IL6
47 cataract, total congenital 10.1 CRP IFNG IL6
48 hemangioma of spleen 10.1 CRP IFNG IL6
49 female breast upper-inner quadrant cancer 10.1 CRP SMUG1 TNFRSF10A
50 multiple mitochondrial dysfunctions syndrome 10.1 CRP IFNG IL6

Comorbidity relations with Temporal Arteritis via Phenotypic Disease Network (PDN): (show all 24)


Active Peptic Ulcer Disease Acute Cystitis
Adrenal Cortical Hypofunction Bronchitis
Cerebral Arteritis Chronic Myocardial Ischemia
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Left Ventricular Outflow Tract Obstruction
Mitral Valve Disease Nonarteritic Anterior Ischemic Optic Neuropathy
Optic Neuritis Osteoporosis
Pituitary Adenoma, Acth-Secreting Polymyositis
Rheumatoid Arthritis Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Temporal Arteritis:



Diseases related to Temporal Arteritis

Symptoms & Phenotypes for Temporal Arteritis

Symptoms by clinical synopsis from OMIM:

187360

Clinical features from OMIM:

187360

Human phenotypes related to Temporal Arteritis:

56 32 (show top 50) (show all 57)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ataxia 56 32 Occasional (29-5%) HP:0001251
2 arthralgia 56 32 Occasional (29-5%) HP:0002829
3 fatigue 56 32 Very frequent (99-80%) HP:0012378
4 myalgia 56 32 Occasional (29-5%) HP:0003326
5 fever 56 32 Very frequent (99-80%) HP:0001945
6 headache 56 32 Very frequent (99-80%) HP:0002315
7 vertigo 56 32 Occasional (29-5%) HP:0002321
8 abdominal pain 56 32 Occasional (29-5%) HP:0002027
9 joint stiffness 56 32 Very frequent (99-80%) HP:0001387
10 muscle weakness 56 32 Occasional (29-5%) HP:0001324
11 amaurosis fugax 56 32 Occasional (29-5%) HP:0100576
12 recurrent pharyngitis 56 32 Occasional (29-5%) HP:0100776
13 ophthalmoparesis 56 32 Frequent (79-30%) HP:0000597
14 ptosis 56 32 Occasional (29-5%) HP:0000508
15 nystagmus 56 32 Occasional (29-5%) HP:0000639
16 diplopia 56 32 Occasional (29-5%) HP:0000651
17 depression 56 32 Frequent (79-30%) HP:0000716
18 hyperhidrosis 56 32 Occasional (29-5%) HP:0000975
19 sudden cardiac death 56 32 Occasional (29-5%) HP:0001645
20 arthritis 56 32 Frequent (79-30%) HP:0001369
21 visual impairment 56 32 Frequent (79-30%) HP:0000505
22 optic atrophy 56 32 Occasional (29-5%) HP:0000648
23 renal insufficiency 56 32 Occasional (29-5%) HP:0000083
24 weight loss 56 32 Very frequent (99-80%) HP:0001824
25 abnormality of the pleura 56 32 Occasional (29-5%) HP:0002103
26 aortic dissection 56 32 Occasional (29-5%) HP:0002647
27 skin ulcer 56 32 Occasional (29-5%) HP:0200042
28 visual field defect 56 32 Occasional (29-5%) HP:0001123
29 anorexia 56 32 Very frequent (99-80%) HP:0002039
30 cerebral ischemia 56 32 Very frequent (99-80%) HP:0002637
31 paresthesia 56 32 Occasional (29-5%) HP:0003401
32 hematuria 56 32 Occasional (29-5%) HP:0000790
33 diabetes insipidus 56 32 Occasional (29-5%) HP:0000873
34 visual loss 56 32 Occasional (29-5%) HP:0000572
35 conductive hearing impairment 56 32 Occasional (29-5%) HP:0000405
36 abnormality of thrombocytes 56 32 Occasional (29-5%) HP:0001872
37 epistaxis 56 32 Occasional (29-5%) HP:0000421
38 pericarditis 56 32 Occasional (29-5%) HP:0001701
39 meningitis 56 32 Occasional (29-5%) HP:0001287
40 alopecia 56 32 Frequent (79-30%) HP:0001596
41 cough 56 32 Occasional (29-5%) HP:0012735
42 vasculitis 56 32 Very frequent (99-80%) HP:0002633
43 hepatic failure 56 32 Occasional (29-5%) HP:0001399
44 arterial thrombosis 56 32 Occasional (29-5%) HP:0004420
45 mediastinal lymphadenopathy 56 32 Occasional (29-5%) HP:0100721
46 gastrointestinal infarctions 56 32 Occasional (29-5%) HP:0005244
47 chewing difficulties 56 32 Very frequent (99-80%) HP:0005216
48 gangrene 56 32 Occasional (29-5%) HP:0100758
49 glossitis 56 32 Occasional (29-5%) HP:0000206
50 elevated erythrocyte sedimentation rate 56 32 Frequent (79-30%) HP:0003565

UMLS symptoms related to Temporal Arteritis:


back pain, exanthema, muscle cramp, muscle rigidity, muscle spasticity, pruritus, sciatica, muscle weakness, myalgia, angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Temporal Arteritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 IL6 PTPN22 TNFRSF10A CCL2 CCL5 CD40LG

Drugs & Therapeutics for Temporal Arteritis

Drugs for Temporal Arteritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 53-03-2 5865
2 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
3 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
4 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
5 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
6 Hormones Phase 4,Phase 2,Phase 3,Phase 1
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
8 Omega 3 Fatty Acid Nutraceutical Phase 4
9
Infliximab Approved Phase 3,Phase 2 170277-31-3
10
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
12
Hydroxychloroquine Approved Phase 3 118-42-3 3652
13
Adalimumab Approved Phase 3 331731-18-1 16219006
14
Etanercept Approved, Investigational Phase 3 185243-69-0
15
Alendronate Approved Phase 3 121268-17-5, 66376-36-1 2088
16
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
17
Alfacalcidol Approved, Nutraceutical Phase 3 41294-56-8 5282181
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
19
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 54575, 6560146 143
20 Antirheumatic Agents Phase 3,Phase 2
21 Dermatologic Agents Phase 3,Phase 2,Phase 1
22 Gastrointestinal Agents Phase 3,Phase 2
23 Anti-Infective Agents Phase 3
24 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
25 Peripheral Nervous System Agents Phase 3,Phase 2
26 Antiemetics Phase 2, Phase 3
27 Autonomic Agents Phase 2, Phase 3
28 Methylprednisolone acetate Phase 2, Phase 3
29 Methylprednisolone Hemisuccinate Phase 2, Phase 3
30 Neuroprotective Agents Phase 2, Phase 3
31 Prednisolone acetate Phase 2, Phase 3
32 Prednisolone hemisuccinate Phase 2, Phase 3
33 Prednisolone phosphate Phase 2, Phase 3
34 Protective Agents Phase 2, Phase 3
35 Pharmaceutical Solutions Phase 3
36 Antimalarials Phase 3
37 Antiparasitic Agents Phase 3
38 Antiprotozoal Agents Phase 3
39 Analgesics Phase 3
40 Analgesics, Non-Narcotic Phase 3
41 Anti-Inflammatory Agents, Non-Steroidal Phase 3
42 Bone Density Conservation Agents Phase 3
43 Hydroxycholecalciferols Phase 3
44 Micronutrients Phase 3
45 Trace Elements Phase 3
46 vitamin d Phase 3
47 Vitamins Phase 3
48 Antimetabolites Phase 3,Phase 2
49 Antimetabolites, Antineoplastic Phase 3,Phase 2
50 Folic Acid Antagonists Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 62)
id Name Status NCT ID Phase
1 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4
2 Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica Patients Completed NCT01169597 Phase 4
3 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
4 Infliximab Therapy in Patients With Refractory Polymyalgia Rheumatica Unknown status NCT01423591 Phase 3
5 Hydroxychloroquine in Giant Cell Arteritis Completed NCT00430807 Phase 3
6 HECTHOR: Humira to Spare Steroids in Giant Cell Arteritis Completed NCT00305539 Phase 3
7 Etanercept Treatment in the Early Course of Polymyalgia Rheumatica Completed NCT00524381 Phase 3
8 Timed Release Tablet Prednisone in Polymyalgia Rheumatica Completed NCT00836810 Phase 2, Phase 3
9 Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol. Completed NCT00138983 Phase 3
10 Efficacy and Safety Study of Sirukumab in Patients With Giant Cell Arteritis Recruiting NCT02531633 Phase 3
11 Safety and Efficacy of tocilizuMAb Versus Placebo in Polymyalgia rHeumatica With glucocORticoid dEpendence SEMAPHORE Recruiting NCT02908217 Phase 3
12 An Efficacy and Safety Study of Tocilizumab (RoActemra/Actemra) in Participants With Giant Cell Arteritis (GCA) Active, not recruiting NCT01791153 Phase 3
13 Giant Cell Arteritis and Anakinra Trial Not yet recruiting NCT02902731 Phase 3
14 Efficacy and Safety Study of Sirukumab in Subjects With Polymyalgia Rheumatica Not yet recruiting NCT02899026 Phase 3
15 A Study Assessing the Efficacy and Safety of Lodotra® Compared to Prednisone IR in Subjects Suffering From PMR Terminated NCT01821040 Phase 3
16 Evaluation of Tocilizumab as an add-on Therapy to Corticoids in Horton's Disease: Proof of Concept Study. Unknown status NCT01910038 Phase 2
17 Tocilizumab for Patients With Giant Cell Arteritis Completed NCT01450137 Phase 2
18 Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's Arteritis Completed NCT00556439 Phase 2
19 Phase II Randomized Study of Glucocorticoids With or Without Methotrexate for Treatment of Giant Cell Arteritis Completed NCT00004686 Phase 2
20 Study of Tocilizumab to Treat Polymyalgia Rheumatica Completed NCT01396317 Phase 2
21 Tocilizumab Effect iN pOlymyalgia Rheumatica Completed NCT01713842 Phase 2
22 Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis Completed NCT01789320 Phase 1, Phase 2
23 Ustekinumab for the Treatment of Giant Cell Arteritis Recruiting NCT02955147 Phase 1, Phase 2
24 Baricitinib in Relapsing Giant Cell Arteritis Recruiting NCT03026504 Phase 2
25 A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Giant Cell Arteritis Terminated NCT00076726 Phase 2
26 A 3-arm Proof of Concept Study of AIN457, ACZ885 or Corticosteroids in Patients With Polymyalgia Rheumatica Terminated NCT01364389 Phase 2
27 Delayed Release Prednisone in PMR Terminated NCT02702778 Phase 2
28 MRI Superficial Temporal Artery Completed NCT00188448 Phase 1
29 Efficacy of Micro-Pulse Steroid Therapy as Induction Therapy in Patients With Polymyalgia Rheumatica Unknown status NCT00982332
30 Study of the T CD8 Immune Response in Horton's Disease Unknown status NCT02158208
31 Diagnostic Study of Temporal Arteritis Unknown status NCT01130857
32 Quantitative and Functional Study of TH17 Lymphocytes in Horton's Disease (HD) Unknown status NCT02065297
33 Sensitivity and Specificity of Color Doppler Directed Temporal Artery Biopsy as Compared to Standard Random Biopsy in the Diagnosis of Temporal Arteritis Unknown status NCT00361192 Early Phase 1
34 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055
35 Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis Completed NCT01795456
36 Temporal Artery Biopsy vs ULtrasound in Diagnosis of GCA (TABUL) Completed NCT00974883
37 Lymphocyte and Cytokine Disturbances in Polymyalgia Rheumatica Completed NCT02888496
38 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
39 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
40 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
41 Impact of Vasculitis on Employment and Income Completed NCT02476292
42 Magnetic Resonance Angiography vs Ultrasonography in Systemic Large vEssel vasculitiS Completed NCT02042092
43 Determining Disease Activity Biomarkers in Individuals With Giant Cell Arteritis Recruiting NCT00315497
44 Biomarkers in Giant Cells Arteritis Recruiting NCT02844023
45 Prospective Follow-up Study of the Aortic Diameter in Patients With Giant Cell Arteritis Recruiting NCT01588483
46 Study of Circulating Microparticles in Giant Cell Arteritis Recruiting NCT02333708
47 Study of Phenotypic and Functional Characteristics of Regulatory T Lymphocytes in Horton's Disease Recruiting NCT02857192
48 Validation of a Diagnostic Algorithm of Giant Cell Arteritis Recruiting NCT02703922
49 Improving the Diagnosis and Prognostication of GCA Through the Novel Use of PET Scan and Immune Biomarkers Recruiting NCT02771483
50 Interest of Medical Imaging in the Diagnostic Strategy Vis a Vis a Suspected Horton Disease Recruiting NCT02473029

Search NIH Clinical Center for Temporal Arteritis

Cochrane evidence based reviews: giant cell arteritis

Genetic Tests for Temporal Arteritis

Anatomical Context for Temporal Arteritis

MalaCards organs/tissues related to Temporal Arteritis:

39
Testes, Tongue, Skin, Brain, Spinal Cord, Bone, Endothelial

Publications for Temporal Arteritis

Articles related to Temporal Arteritis:

(show top 50) (show all 538)
id Title Authors Year
1
Studies on the Histopathology of Temporal Arteritis. ( 28275606 )
2017
2
Metaplastic ossification of the temporal artery with osteoclast-like giant cells: a mimicker of giant cell (temporal) arteritis. ( 28315516 )
2017
3
Hypertrophic Pachymeningitis as a Potential Cause of Headache Associated with Temporal Arteritis. ( 26935376 )
2016
4
When a temporal artery biopsy reveals a diagnosis other than temporal arteritis: eosinophilic granulomatosis with polyangiitis. ( 27316282 )
2016
5
Temporal Arteritis With Arteritic Anterior Ischemic Optic Neuropathy is Bilateral Until Proven Otherwise: Response. ( 27855129 )
2016
6
The Temporal Arteritis Proforma: Should cough be included? ( 27592336 )
2016
7
Bilateral Blindness in a Patient With Temporal Arteritis After Wisdom Tooth Extraction. ( 26854772 )
2016
8
VZV, temporal arteritis, and clinical practice: False positive immunohistochemical detection due to antibody cross-reactivity. ( 26688577 )
2016
9
Juvenile temporal arteritis with eosinophilia associated with systemic sclerosis. ( 27401371 )
2016
10
Is All Inflammation within Temporal Artery Biopsies Temporal Arteritis? ( 27445262 )
2016
11
Preserved Visual Acuity in Anterior Ischemic Optic Neuropathy Secondary to Giant Cell (temporal) Arteritis. ( 26958148 )
2016
12
Temporal arteritis with erythrocyte sedimentation rate <50 mm/h: a clinical reminder. ( 26966355 )
2016
13
Extracranial cutaneous manifestation of temporal arteritis--a case of erythematous plaques on the legs. ( 26713645 )
2016
14
Annular Elastolytic Giant Cell Granuloma and Temporal Arteritis Following Herpes Zoster. ( 26861435 )
2015
15
Waldenstrom Macroglobulinemia Mimicking Temporal Arteritis. ( 25996301 )
2015
16
The effect of temporal artery biopsy on the treatment of temporal arteritis. ( 25457237 )
2015
17
A case of temporal arteritis in Filippino Lippi's (1459-1504) Saint Frediano? ( 26638160 )
2015
18
Elderly woman with headache. Giant cell arteritis/temporal arteritis. ( 25910765 )
2015
19
Annular Elastolytic Giant Cell Granuloma and Temporal Arteritis Following Herpes Zoster. ( 26861422 )
2015
20
Magnetic Resonance Imaging of Temporal Arteritis: A Case Report. ( 25758708 )
2015
21
Giant cell arteritis (temporal arteritis) revisited. ( 26448217 )
2015
22
Calciphylaxis of the temporal artery masquerading as temporal arteritis: a case presentation and review of the literature. ( 25903821 )
2015
23
Giant Cell Arteritis of the Female Genital Tract With Occult Temporal Arteritis and Marginal Zone Lymphoma Harboring Novel 20q Deletion: A Case Report and Literature Review. ( 26353853 )
2015
24
Monckeberg's Arteriosclerosis in Temporal Arteritis Suspect. ( 26711297 )
2015
25
The role of ultrasound in the diagnosis of temporal arteritis. ( 25890932 )
2015
26
Fatal Calciphylaxis Presenting as Polymyalgia Rheumatica and Temporal Arteritis. ( 26583498 )
2015
27
Polyarteritis nodosa mimicking giant cell (temporal) arteritis. ( 25030583 )
2014
28
Perivascular Marginal Zone Lymphoma Mimicking Temporal Arteritis. ( 25361636 )
2014
29
High-resolution color-coded ultrasonography findings of subacute temporal arteritis with ulcerating skin lesions. ( 25047586 )
2014
30
Primary systemic Al amyloidosis presenting as temporal arteritis. ( 24551471 )
2014
31
A rare case of temporal arteritis with rheumatoid arthritis and interstitial lung disease mimicking pulpo-periodontal pathology. ( 25210275 )
2014
32
Temporal Artery Calciphylaxis Presenting as Temporal Arteritis in a Case of Rhinoorbitocerebral Mucormycosis. ( 24853118 )
2014
33
Temporal ultrasonography findings in temporal arteritis: early disappearance of halo sign after only 2 days of steroid treatment. ( 23300333 )
2013
34
Amyloid deposits in temporal artery mimicking temporal arteritis in a patient with multiple myeloma. ( 24232087 )
2013
35
Vertebrobasilar Infarction Related to Giant Cell (Temporal) Arteritis: Case Report. ( 24390182 )
2013
36
Morphological features of temporal arteritis. ( 23543964 )
2013
37
Juvenile temporal arteritis. ( 23294490 )
2013
38
Scalp necrosis in temporal arteritis: abrupt termination of the superficial temporal artery as a possible precursor. ( 23331479 )
2013
39
Temporal arteritis in a young patient. ( 24143876 )
2013
40
Methotrexate in refractory bilateral juvenile temporal arteritis: Report of a case. ( 24252028 )
2013
41
Stellate ganglion block as an early intervention in sympathetically maintained headache and orofacial pain caused by temporal arteritis. ( 23332006 )
2013
42
Temporal arteritis in the young. ( 23142255 )
2013
43
Temporal arteritis: improving patient evaluation with a new protocol. ( 23596371 )
2013
44
The activation pattern of macrophages in giant cell (temporal) arteritis and primary angiitis of the central nervous system. ( 24354510 )
2013
45
The role of ultrasound biomicroscopy in the diagnosis of temporal arteritis. ( 23431722 )
2012
46
Headache and temporal arteritis: when to suspect and how to manage. ( 22552735 )
2012
47
Giant cell temporal arteritis associated with overlying basal cell carcinoma: co-incidence or connection? ( 23087802 )
2012
48
TEMPL3: a simple mnemonic for the diagnosis of temporal arteritis. ( 23577360 )
2012
49
Temporal arteritis: A case series from south India and an update of the Indian scenario. ( 22412269 )
2012
50
Steroid-induced sigmoid diverticular perforation in a patient with temporal arteritis: a rare clinical pathology. ( 22493565 )
2012

Variations for Temporal Arteritis

Expression for Temporal Arteritis

Search GEO for disease gene expression data for Temporal Arteritis.

Pathways for Temporal Arteritis

Pathways related to Temporal Arteritis according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 CCL2 CCL5 CD40LG CRP HLA-DRB1 IFNG
2
Show member pathways
13.09 CCL2 CCL5 CD40LG HLA-DRB1 IFNG IL1RN
3
Show member pathways
13.07 CCL2 CCL5 CD40LG IL6 PTPN22 TNFRSF10A
4
Show member pathways
12.54 CCL2 CCL5 HLA-DRB1 IFNG IL6 TNFRSF10A
5 12.13 CCL2 CCL5 CD40LG IFNG IL1RN PTPN22
6 11.8 CCL2 IFNG IL6
7 11.75 CCL2 CCL5 IL6
8 11.49 CCL2 CCL5 IL6
9
Show member pathways
11.47 CD40LG IFNG IL6
10
Show member pathways
11.43 CCL2 CCL5 CRP IFNG IL6 SERPINA3
11 11.31 CCL2 CCL5 IL1RN IL6
12 11.31 CCL2 CCL5 HLA-DRB1 IFNG IL6
13 11.25 CCL2 CD40LG IFNG IL6
14 11.06 HLA-DRB1 IFNG IL6
15 10.99 CCL2 CCL5 CD40LG IL6
16 10.85 CCL2 SERPINA3
17 10.84 CRP IL6

GO Terms for Temporal Arteritis

Cellular components related to Temporal Arteritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 APOH CCL2 CCL5 CD40LG CRP IFNG
2 external side of plasma membrane GO:0009897 9.46 CD40LG HLA-DRB1 IFNG IL6
3 extracellular space GO:0005615 9.28 APOH CCL2 CCL5 CD40LG CRP IFNG

Biological processes related to Temporal Arteritis according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.9 CRP IFNG IL6 PTPN22
2 T cell receptor signaling pathway GO:0050852 9.81 HLA-DRB1 IFNG PTPN22
3 response to lipopolysaccharide GO:0032496 9.81 CCL2 IL6 PTPN22 TNFRSF10A
4 cellular response to lipopolysaccharide GO:0071222 9.79 CCL2 IFNG IL6
5 cellular response to tumor necrosis factor GO:0071356 9.78 CCL2 CCL5 IL6
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 CCL2 CCL5 IL6 PTPN22
7 cellular response to interleukin-1 GO:0071347 9.74 CCL2 CCL5 IL6
8 response to glucocorticoid GO:0051384 9.73 CCL2 IL1RN IL6
9 neutrophil chemotaxis GO:0030593 9.72 CCL2 CCL5 IFNG
10 humoral immune response GO:0006959 9.71 CCL2 IFNG IL6
11 positive regulation of cell adhesion GO:0045785 9.67 CCL2 CCL5 IFNG
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 CCL5 IFNG IL6
13 defense response to protozoan GO:0042832 9.63 IFNG IL6
14 positive regulation of JAK-STAT cascade GO:0046427 9.63 CCL5 IL6
15 positive regulation of monocyte chemotaxis GO:0090026 9.62 CCL2 CCL5
16 positive regulation of macrophage chemotaxis GO:0010759 9.61 CCL2 CCL5
17 macrophage chemotaxis GO:0048246 9.59 CCL2 CCL5
18 positive regulation of protein import into nucleus, translocation GO:0033160 9.58 IFNG IL6
19 negative regulation of lipid storage GO:0010888 9.58 CRP IL6
20 monocyte chemotaxis GO:0002548 9.58 CCL2 CCL5 IL6
21 immune response GO:0006955 9.56 CCL2 CCL5 CD40LG HLA-DRB1 IFNG IL1RN
22 regulation of vascular endothelial growth factor production GO:0010574 9.52 CCL2 IL6
23 acute-phase response GO:0006953 9.5 CRP IL6 SERPINA3
24 positive regulation of T cell proliferation GO:0042102 9.46 CCL5 CD40LG IFNG IL6
25 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.43 IL1RN IL6
26 lipopolysaccharide-mediated signaling pathway GO:0031663 9.43 CCL2 CCL5 PTPN22
27 neutrophil apoptotic process GO:0001781 9.37 IFNG IL6
28 inflammatory response GO:0006954 9.23 CCL2 CCL5 CD40LG CRP IL1RN IL6

Molecular functions related to Temporal Arteritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL2 CCL5 CD40LG IFNG IL1RN IL6

Sources for Temporal Arteritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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