MCID: TMP001
MIFTS: 59

Temporal Lobe Epilepsy malady

Neuronal diseases category
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Summaries for Temporal Lobe Epilepsy

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Wikipedia:65 Temporal lobe epilepsy is a chronic neurological condition characterized by recurrent, unprovoked... more...

MalaCards based summary: Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to febrile seizures and encephalitis. An important gene associated with Temporal Lobe Epilepsy is CASP2 (caspase 2, apoptosis-related cysteine peptidase), and among its related pathways are Interaction between L1 and Ankyrins and Neuroscience. The drugs phenytoin and phenytoin sodium and the compounds dodecylphosphocholine and dimyristoylphosphatidylcholine have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and cortex, and related mouse phenotypes are adipose tissue and mortality/aging.

Aliases & Classifications for Temporal Lobe Epilepsy

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Temporal Lobe Epilepsy, Aliases & Descriptions:

Name: Temporal Lobe Epilepsy 30 8
Epilepsy, Temporal Lobe 8 62
 
Epilepsy Temporal Lobe 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:3328
MeSH34 D004833

Related Diseases for Temporal Lobe Epilepsy

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Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1febrile seizures31.2SCN1A, LGI1, SCN1B
2encephalitis31.1PDYN, TSPO, LGI1
3frontal lobe epilepsy31.1SCN1B, SCN1A
4juvenile myoclonic epilepsy31.0SCN1A, GABBR1
5memory impairment30.8HTR1A, TSPO, APOE, PDYN
6idiopathic generalized epilepsy30.7SCN1B, LGI1
7mood disorder30.5RELN, HTR1A, GABBR1, PDYN
8psychotic disorder30.5RELN, HTR1A, PDYN
9obsessive-compulsive disorder30.4PDYN, TSPO, HTR1A
10dementia30.4HTR1A, APOE, TSPO
11schizophrenia30.0GABBR1, TSPO, PDYN, HTR1A, RELN
12epilepsy syndrome29.2GABBR1, SCN1A, HTR1A, PDYN, CASP2, LGI1
13mesial temporal lobe epilepsy with hippocampal sclerosis11.0
14neuronitis10.9
15status epilepticus10.7
16cerebritis10.6
17limbic encephalitis10.5
18scn1a-related seizure disorders10.5SCN1A
19autosomal dominant partial epilepsy with auditory features10.5
20encephalocele10.5
21temporal epilepsy, familial10.5
22epilepsy, familial temporal lobe, 110.5
23benign familial mesial temporal lobe epilepsy10.5
24hepatic coma10.5TSPO
25parametritis10.4
26chorea-acanthocytosis10.4
27acanthocytosis10.4
28chorea10.4
29syncope10.4
30seasonal affective disorder10.4HTR1A
31transvestism10.3
32tetanus10.3
33autonomic dysfunction10.3
34seizure disorder10.3
35infantile-onset mesial temporal lobe epilepsy with severe cognitive regression10.3
36withdrawal disorder10.3GABBR1, PDYN
37drug addiction10.3GABBR1, PDYN
38creutzfeldt-jakob disease10.3TSPO, APOE
39frontotemporal dementia10.2RELN, APOE
40vascular dementia10.2HTR1A, APOE
41generalized anxiety disorder10.2TSPO, HTR1A
42west syndrome10.2
43acute lymphoblastic leukemia10.2
44insulinoma10.2
45leukemia10.2
46major depressive disorder10.2
47malaria10.2
48systemic lupus erythematosus10.2
49dysembryoplastic neuroepithelial tumor10.2
50choroid plexus papilloma10.2

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to temporal lobe epilepsy

Symptoms for Temporal Lobe Epilepsy

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Drugs & Therapeutics for Temporal Lobe Epilepsy

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Drug clinical trials:

Search ClinicalTrials for Temporal Lobe Epilepsy

Search NIH Clinical Center for Temporal Lobe Epilepsy

Inferred drug relations via UMLS62/NDF-RT40:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Genetic Tests for Temporal Lobe Epilepsy

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Anatomical Context for Temporal Lobe Epilepsy

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MalaCards organs/tissues related to Temporal Lobe Epilepsy:

32
Temporal lobe, Brain, Cortex, Bone, Amygdala, Testes, Cerebellum, Heart, Skin, Prefrontal cortex, Olfactory bulb

Animal Models for Temporal Lobe Epilepsy or affiliated genes

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MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7PDYN, ACOT7, APOE, LGI1, GABBR1
2MP:00107687.8SCN1A, SCN1B, GABBR1, RELN, LGI1, HTR1A
3MP:00053787.3GABBR1, PDYN, LGI1, RELN, APOE, ACOT7
4MP:00053867.2ACOT7, HTR1A, SCN1A, RELN, APOE, PDYN
5MP:00036316.6SCN1A, GABBR1, PDYN, CALHM1, CASP2, ACOT7

Publications for Temporal Lobe Epilepsy

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Articles related to Temporal Lobe Epilepsy:

(show top 50)    (show all 819)
idTitleAuthorsYear
1
Ictal and postictal semiology in patients with bilateral temporal lobe epilepsy. (25282104)
2014
2
Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy. (23398413)
2013
3
Defining "epileptogenesis" and identifying "antiepileptogenic targets" in animal models of acquired temporal lobe epilepsy is not as simple as it might seem. (22342985)
2013
4
Impaired and facilitated functional networks in temporal lobe epilepsy. (24073391)
2013
5
P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study. (23786896)
2013
6
Characteristics of temporal lobe epilepsy with no ictal impairment of consciousness. (23369403)
2013
7
Functional connectivity estimated from intracranial EEG predicts surgical outcome in intractable temporal lobe epilepsy. (24205027)
2013
8
The strange sensation of deja vu: not so strange in temporal lobe epilepsy. (23457224)
2013
9
Application of dynamic susceptibility contrast-enhanced perfusion in temporal lobe epilepsy. (23117196)
2013
10
Subtle temporal lobe epilepsy with headache as the major complaint: what can we learn from the long-delayed diagnosis? (23290451)
2013
11
Resting state networks in temporal lobe epilepsy. (24117098)
2013
12
Sleep modulation of epileptic activity in mesial and neocortical temporal lobe epilepsy: a study with depth and subdural electrodes. (23751358)
2013
13
Enhanced sequential reaction time task performance in a rat model of mesial temporal lobe epilepsy with classic hippocampal sclerosis. (23511251)
2013
14
Mesial temporal lobe epilepsy in a patient with spinocerebellar ataxia type 13 (SCA13). (23215817)
2013
15
Outcomes for temporal lobe epilepsy operations may not be equal: a call for an RCT of ATL vs SAH. (23553476)
2013
16
Whole mitochondrial DNA variations in hippocampal surgical specimens and blood samples with high-throughput sequencing: a case of mesial temporal lobe epilepsy with hippocampal sclerosis. (23872536)
2013
17
A more realistic approach, using dynamic stimuli, to test facial emotion recognition impairment in temporal lobe epilepsy. (23648274)
2013
18
Increased metallothionein I/II expression in patients with temporal lobe epilepsy. (23028585)
2012
19
Critically appraised topic. Temporal lobe epilepsy and hippocampal stimulation. (23041406)
2012
20
Pathophysiology of mood disorders in temporal lobe epilepsy. (23429849)
2012
21
Changes in interictal spike features precede the onset of temporal lobe epilepsy. (22718546)
2012
22
Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy. (22238156)
2012
23
Temporal Lobe Epilepsy and the BDNF Receptor, TrkB (22787630)
2012
24
Medial temporal lobe epilepsy is associated with neuronal fibre loss and paradoxical increase in structural connectivity of limbic structures. (22764263)
2012
25
Serious adverse effects of gamma knife radiosurgery for mesial temporal lobe epilepsy. (23269044)
2012
26
Mesial temporal sclerosis is linked with more widespread white matter changes in temporal lobe epilepsy. (24179742)
2012
27
Prominent oligodendroglial response in surgical specimens of patients with temporal lobe epilepsy. (23083461)
2012
28
State-dependent precursors of seizures in correlation-based functional networks of electrocorticograms of patients with temporal lobe epilepsy. (22271261)
2012
29
Aberrant glutamate receptor 5 expression in temporal lobe epilepsy lesions. (19941835)
2010
30
Functional variant in complement C3 gene promoter and genetic susceptibility to temporal lobe epilepsy and febrile seizures. (20862287)
2010
31
Changes in the expression of selenoproteins in mesial temporal lobe epilepsy patients. (19499324)
2009
32
Spatiotemporospectral characteristics of scalp ictal EEG in mesial temporal lobe epilepsy with hippocampal sclerosis. (19563787)
2009
33
Surgery for temporal lobe epilepsy after cerebral malaria. (18515154)
2008
34
A componential analysis of proverb interpretation in patients with frontal lobe epilepsy and temporal lobe epilepsy: relationships with disease-related factors. (17853125)
2008
35
A Kv4.2 truncation mutation in a patient with temporal lobe epilepsy. (16934482)
2006
36
Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy. (16121124)
2006
37
Lack of GABABR1 gene variation (G1465A) in a Chinese population with temporal lobe epilepsy. (16278087)
2005
38
Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy. (15694259)
2005
39
Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. (15057313)
2004
40
Perivascular clustering in temporal lobe epilepsy: oligodendroglial cells of unknown function. (15480711)
2004
41
Reduction of hippocampal collapsin response mediated protein-2 in patients with mesial temporal lobe epilepsy. (15672539)
2004
42
Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. (12122039)
2002
43
Chronic encephalitis and temporal lobe epilepsy: a variant of Rasmussen's syndrome? (11245727)
2001
44
Inter-ictal and post-ictal psychoses in frontal lobe epilepsy: a retrospective comparison with psychoses in temporal lobe epilepsy. (10933987)
2000
45
Ultrastructural localization of dynorphin in the dentate gyrus in human temporal lobe epilepsy: a study of reorganized mossy fiber synapses. (10098940)
1999
46
Disturbance of visual information processing in temporal lobe epilepsy: in comparison with idiopathic generalized epilepsy. (8271589)
1993
47
MRI in the presurgical evaluation of patients with frontal lobe epilepsy and children with temporal lobe epilepsy: pathologic correlation and prognostic importance. (1563338)
1992
48
Developmental anterobasal temporal encephalocele and temporal lobe epilepsy. (2033453)
1991
49
Schizophrenia-like psychosis with Capgras syndrome in a patient with right temporal lobe epilepsy--a case report. (4095563)
1985
50
Transient global amnesia: manifestation of medial temporal lobe epilepsy. (455733)
1979

Variations for Temporal Lobe Epilepsy

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Expression for genes affiliated with Temporal Lobe Epilepsy

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Expression patterns in normal tissues for genes affiliated with Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for genes affiliated with Temporal Lobe Epilepsy

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Compounds for genes affiliated with Temporal Lobe Epilepsy

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Compounds related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1dodecylphosphocholine4410.3APOE, PDYN
2dimyristoylphosphatidylcholine4410.2PDYN, APOE
3damgo44 28 6112.2GABBR1, PDYN
4benzodiazepines4410.2TSPO, GABBR1
522r-hydroxycholesterol44 2811.2APOE, TSPO
6gamma-hydroxybutyrate4410.1TSPO, GABBR1
7baclofen44 1111.1TSPO, GABBR1
8nitrazepam44 1111.1TSPO, SCN1A
9bicuculline44 2811.1GABBR1, TSPO
10abecarnil4410.1HTR1A, TSPO
11carbon-114410.1TSPO, HTR1A
12benzodiazepine4410.0GABBR1, TSPO
13buspirone44 28 1112.0TSPO, HTR1A
14dopac4410.0SCG2, GABBR1
15clonazepam44 1111.0TSPO, GABBR1
16tetrodotoxin citrate6110.0SCN1A, SCN1B
17qx 314 chloride6110.0SCN1B, SCN1A
18phrixotoxin 36110.0SCN1B, SCN1A
19muscimol44 61 2812.0TSPO, GABBR1
20scopolamine44 28 24 1113.0TSPO, HTR1A
21veratridine44 61 2812.0SCN1A, SCN1B
22thiamine44 2 24 1112.9APOE, TSPO
23picrotoxin44 28 1111.9GABBR1, TSPO
24fluvoxamine44 50 1111.9HTR1A, TSPO
25pentylenetetrazol449.9TSPO, PDYN, GABBR1
26clomipramine44 50 1111.9HTR1A, TSPO
27naloxone44 28 50 1112.9GABBR1, PDYN, TSPO
28opiate449.9GABBR1, TSPO, PDYN
29l-tryptophan50 28 44 24 1113.8HTR1A, TSPO
30cocaine44 1110.8TSPO, GABBR1, PDYN
31nicotine44 28 50 1112.8PDYN, TSPO, APOE
32tetrodotoxin44 61 2811.8SCN1B, SCN1A, APOE
33spec-t449.7APOE, TSPO
34levodopa44 1110.7HTR1A, PDYN, TSPO
35amitriptyline44 28 50 1112.7HTR1A, GABBR1
36glutamine449.6PDYN, TSPO, APOE, CASP2
37morphine44 50 28 1112.6TSPO, CASP2, PDYN, GABBR1
38kainate44 2810.6TSPO, GABBR1, PDYN, APOE
39gaba449.6GABBR1, RELN, TSPO, PDYN
40glutamate449.3APOE, TSPO, RELN, PDYN, GABBR1
41gnrh449.3SCG2, GABBR1, PDYN
42zonisamide44 50 1111.3SCN1B, SCN1A
435-hydroxytryptamine449.2GABBR1, TSPO, HTR1A, SCG2
44cysteine449.1GABBR1, PDYN, CASP2, APOE, SCG2
45adenylate449.1SCG2, HTR1A, PDYN, GABBR1
46nmda44 289.9HTR1A, APOE, TSPO, RELN, PDYN, GABBR1
47norepinephrine44 24 1110.9GABBR1, PDYN, TSPO, SCG2, HTR1A
48potassium44 24 1110.9SCN1A, GABBR1, LGI1, PDYN, CASP2, SCN1B
49acetylcholine44 50 28 24 1112.7GABBR1, PDYN, HTR1A, TSPO, APOE, SCG2
50dopamine44 28 24 1111.6SCG2, APOE, TSPO, HTR1A, PDYN, GABBR1

GO Terms for genes affiliated with Temporal Lobe Epilepsy

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Cellular components related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:0015189.7SCN1B, SCN1A
2node of RanvierGO:0332689.7SCN1B, SCN1A
3intercalated discGO:0147049.6SCN1A, SCN1B
4T-tubuleGO:0303159.5SCN1A, SCN1B
5dendriteGO:0304259.4GABBR1, RELN, APOE
6extracellular regionGO:0055768.7PDYN, SCN1B, APOE, GABBR1, LGI1

Biological processes related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system axon regenerationGO:01401210.0APOE, TSPO
2regulation of behaviorGO:0507959.8RELN, HTR1A
3negative regulation of endothelial cell proliferationGO:0019379.7SCG2, APOE
4neuronal action potential propagationGO:0192279.7SCN1A, SCN1B
5agingGO:0075689.5APOE, TSPO, CASP2
6synaptic transmissionGO:0072688.5SCN1B, TSPO, PDYN, GABBR1

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle receptor bindingGO:0703269.7RELN, APOE
2voltage-gated sodium channel activityGO:0052489.6SCN1B, SCN1A

Products for genes affiliated with Temporal Lobe Epilepsy

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Sources for Temporal Lobe Epilepsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet