Temporal Lobe Epilepsy malady

Wikipedia: Temporal lobe epilepsy is a form of focal epilepsy, a chronic neurological condition characterized by...⁴⁴ more...

MalaCards: Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to febrile seizures and absence epilepsy. An important gene associated with Temporal Lobe Epilepsy is ACOT7 (acyl-CoA thioesterase 7), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Axon guidance. The drugs phenytoin sodium,prompt and phenytoin sodium,extended and the compounds glucose and chloride have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and cortex, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Aliases & Descriptions:

temporal lobe epilepsy 6 epilepsy, temporal lobe 6 43 temporal lobe epilepsy (disorder) 6

epilepsy temporal lobe 32 epilepsy 43

Diseases related to temporal lobe epilepsy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 977)

id	Related Disease	Score	Top Affiliating Genes
1	febrile seizures	35.3	SCN1B, SCN1A, LGI1, NPY
2	absence epilepsy	35.3	SCN1B, LGI4, GRIK1, HTR1A, GLUD1, ABAT
3	idiopathic generalized epilepsy	35.1	KCNJ10, SCN1B, SCN2A, SCN1A, ATP1A2, GRIK2
4	generalized epilepsy with febrile seizures plus	34.6	SCN1B, SCN1A, LGI1, ABAT, TSPO
5	childhood absence epilepsy	34.1	LGI4, GRIK1, GABBR1, GABRA5, GABRB3
6	focal epilepsy	33.9	RELN, SCN1A, LGI1, LGI2, DCX
7	intractable epilepsy	33.2	BDNF, SCN2A, SCN1A, GRIA2, GRIN1, GRM1
8	neuronal migration disorders	32.1	RELN, MAP2, CALB1, CALB2, PVALB, DCX
9	status epilepticus	31.5	CNP, CNR1, BDNF, SCN1A, LGI1, GRIA1
10	severe myoclonic epilepsy of infancy (smei)	31.4	SCN1B, SCN2A, SCN1A
11	juvenile absence epilepsy	31.4	GRIK1, GRIK2, GABRA5, GABRB3
12	focal cortical dysplasia	31.3	INA, GRIN1, GRM5, CALB2, TP53, C19orf48
13	tuberous sclerosis	31.3	GC, S100B, MSN, INTS2, GRM4, MAP2
14	limbic encephalitis	30.9	LGI1, GRIA1, GRIN2B, IL6, GAD1, GAD2
15	paraplegia	30.8	BAMBI, IL6, GJA1, SPAST, PLP1, ACE
16	epilepsy syndrome	30.5	RELN, CNR1, CLU, BDNF, SCN1B, SCN1A
17	spasticity	30.3	CNR1, BAMBI, MMP9, CCL3, GJA1, SPAST
18	epilepsies, partial	29.7	SCN1A, LGI1, GRM1, GRM5, MAOB, PDYN
19	convulsions	29.7	BDNF, SCN1B, SCN2A, SCN1A, LGI4, ATP1A2
20	ataxia	29.6	KCNJ10, SCG2, SCN2A, SCN1A, BAMBI, ATP1A2
21	dentatorubral-pallidoluysian atrophy	29.0	CASP3, CALB2, GFAP, PVALB, SLC1A3
22	rett syndrome	28.9	CLU, BDNF, S100B, GRIA3, APOE, MAP2
23	lennox-gastaut syndrome	28.8	SCN1A, ABAT, DCX
24	cerebellar ataxia	28.6	SCN1A, GRM1, SPAST, PDYN, NDUFS4, PRNP
25	fragile x syndrome	28.4	BDNF, GRIA1, GRIK1, GRM1, GRM5, MAOA
26	encephalitis	27.8	CNP, CNR1, BDNF, SCN1A, LGI1, S100B
27	schizophrenia	27.6	GRIK5, IL1B, IL1RN, MAOA, NOS1, NGFR
28	intellectual disability	27.5	RELN, BDNF, SCN1A, GRIK1, GRIN1, GRM5
29	memory impairment	26.9	CNR1, BDNF, GRIN1, APOE, MAOB, HTR1A
30	seizures	26.9	CNP, CNR1, BDNF, BCL2L11, KCND2, KCNJ10
31	migraine with aura	26.9	SCN1A, ATP1A2, HTR1B, HTR2C, ESR1, ACE
32	aicardi-goutieres syndrome	26.9	GC, SCN1A, AQP4, ENO2, NDUFS4, TSPO
33	bipolar disorder	26.7	BDNF, HTR1A, SLC6A4
34	hemimegalencephaly	26.5	GRIK2, NGF, SLC1A3, SLC1A1, SLC1A2
35	eating disorder	26.4	CNR1, BDNF, HTR1A, NTRK2, CRH, NPY
36	neurodegeneration	26.4	RELN, CNR1, CLU, BDNF, S100B, MOG
37	neuropathy	26.3	CNR1, BDNF, SCN2A, LGI1, CHGA, MSN
38	multiple sclerosis	26.1	MOG, IL1A, IL1B, IL1RN, APOE, TNFRSF1A
39	gastroenteritis	26.0	PCOLCE, SCN1B, SCN1A, IL1B, IL1RN, IL6
40	hyperhomocysteinemia	26.0	IL1B, IL1RN, IL6, APOA1, APOE, MAOB
41	mental retardation syndrome	25.9	RELN, RDX, BDNF, ATP1A2, GRM5, MAOA
42	type 1 diabetes mellitus	25.9	IL1B, IL1RAPL2, APOA1, HLA-S, ACE, NPY
43	dysembryoplastic neuroepithelial tumor	25.8	CHGA, S100B, MKI67, MIB1, GRIN1, MAP2
44	ganglioglioma	25.6	RELN, CHGA, S100B, GRIN1, GRM3, GRM5
45	tremor	25.4	CNR1, APOA1, HTR2C, PLP1, ABCB1, GFAP
46	glioblastoma	25.3	LGI1, MDM2, MAP2, CCNA2, GJA1, TP53
47	peripheral neuropathy	25.2	BDNF, SCN2A, MSN, KARS, GRM2, IL6
48	anxiety disorder	25.2	CNR1, BDNF, MAOA, MAOB, HTR1A, HTR1B
49	neuronitis	24.9	RELN, CNP, CNR1, RDX, SEPW1, SEMA3A
50	periodontitis	24.7	MMP9, IL1A, IL1B, IL1RAPL2, IL1RN, IL6

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 anti-epileptic agent [epc], mephenytoin, phenytoin, phenytoin sodium, phenytoin sodium extended, phenytoin sodium,extended, phenytoin sodium,prompt, primidone

Cell-based therapeutics:

MalaCards organs/tissues related to temporal lobe epilepsy:

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MGI Mouse Phenotypes related to temporal lobe epilepsy:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.4	GAD2, PSEN2, GJA1, GLUD1, CASP2, HTR1B
2	hematopoietic system phenotype	MP:0005397	10.2	SLC4A4, DFFB, EIF2S1, NLRP12, NTRK1, GJA1
3	respiratory system phenotype	MP:0005388	9.8	PSEN2, PRDX3, SLC12A5, ADORA1, ADK, GAD1
4	taste/olfaction phenotype	MP:0005394	9.6	GAD1, SLC6A1, DKK1, NGFR, CASP3, ENO2
5	other phenotype	MP:0005395	9.4	PRNP, ABCC1, ABCB1, NOS1, CRH, TNFRSF1A
6	limbs/digits/tail phenotype	MP:0005371	9.4	TNFRSF1A, NTRK1, NGFR, PSEN2, PRNP, NPY1R
7	renal/urinary system phenotype	MP:0005367	9.0	DAPK1, NGFR, DKK1, PSEN2, SLC1A1, C3
8	no phenotypic analysis	MP:0003012	9.0	DCX, NTRK1, TP53, ESR1, DBP, PRNP
9	normal phenotype	MP:0002873	8.5	SEPT3, BDNF, BCL2L11, SCN1B, BAMBI, MSN
10	digestive/alimentary phenotype	MP:0005381	8.5	GFAP, PDYN, NGFR, NLRP12, NOS1, PSEN2
11	reproductive system phenotype	MP:0005389	8.3	PRL, DCX, PLP1, SPAST, SRD5A1, CYP11A1
12	integument phenotype	MP:0010771	8.1	ATP1A2, NGF, NGFR, PDYN, NDUFS4, PSEN2
13	immune system phenotype	MP:0005387	7.9	NDUFS4, NLRP12, NOS1, PLP1, PLEC, CRH
14	adipose tissue phenotype	MP:0005375	7.8	NOS1, PDYN, ACE, NPY, NPY1R, SLC12A2
15	vision/eye phenotype	MP:0005391	7.5	RELN, CNP, BDNF, KCNJ10, SCN1B, NTRK1
16	skeleton phenotype	MP:0005390	7.5	NDUFS4, PDYN, NOS1, TNFRSF1A, TP53, ESR1
17	muscle phenotype	MP:0005369	7.5	NGFR, NOS1, PLEC, NTRK1, NTF3, CYP11A1
18	mortality/aging	MP:0010768	6.7	PLEC, SLC12A2, SLC12A5, RTN4, C3, ADK
19	nervous system phenotype	MP:0003631	6.5	SLC12A5, RTN4, SIRT2, C3, GABBR1, GABRB2
20	growth/size phenotype	MP:0005378	6.2	PTPRB, PRDX3, NPY, NPY1R, SLC6A1, SLC6A4
21	cardiovascular system phenotype	MP:0005385	6.0	NOS1, PLEC, NTF3, PTPRB, TNFRSF1A, TP53
22	homeostasis/metabolism phenotype	MP:0005376	5.5	NTF3, SOD1, NPY, NPY1R, SLC1A3, SLC1A1
23	cellular phenotype	MP:0005384	5.5	RELN, CNR1, SEMA3A, PALLD, CASP3, CASP6
24	behavior/neurological phenotype	MP:0005386	INF	LGI1, LGI4, BAMBI, S100B, ATP1A2, MOG
25	hearing/vestibular/ear phenotype	MP:0005377	INF	NGFR, ABCB1, OPRL1, , SOD1, SLC1A3

Articles related to temporal lobe epilepsy:

(show top 50)    (show all 213)

id	Title	Authors	Year	Affiliating Genes
1	Selective upregulation of brain-derived neurotrophic factor (BDNF) transcripts and BDNF direct induction of activity independent N-m ethyl-D-aspartate currents in temporal lobe epilepsy patients with hippocampal sclerosis. (21986136)	Wang F.J.... Zhang L.M.	2011	BDNF
2	Kallikrein 1 is overexpressed by astrocytes in the hi ppocampus of patients with refractory temporal lobe epilepsy, associated with h ippocampal sclerosis. (21211543)	SimA/es P.S.... Mazzacoratti M.d.a. .G.	2011	KLK1
3	Effect of apolipoprotein I/4 allele on hippocampal and brain volume in intractable temporal lobe epilepsy. (21317045)	Busch R.M.... Najm I.M.	2011	APOE
4	Upregulation of adenosine kinase in astrocytes in exp erimental and human temporal lobe epilepsy. (21635241)	Aronica E.... Gorter J.A.	2011	ADK
5	A polymorphism in CALHM1 is associated with temporal lobe epilepsy. (21439911)	Lv R.J.... Liu H.	2011	CALHM1
6	Carboxypeptidase A6 gene (CPA6) mutations in a recessive familial form of febrile seizures and temporal lobe epilepsy and in sporadic temporal lobe epilepsy. (21922598)	Salzmann A.... Malafosse A.	2011	CPA6
7	Cannabinoid-mediated inhibition of recurrent excitato ry circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy. (20498848)	Bhaskaran M.D.... Smith B.N.	2010	CNR1
8	Temporal lobe epilepsy and matrix metalloproteinase 9 : a tempting relation but negative genetic association. (20605480)	Heuser K.... Ottersen O.P.	2010	MMP9
9	Effects of lamotrigine and topiramate on hippocampal neurogenesis in experimental temporal-lobe epilepsy. (20025852)	Chen J.... Jiang W.	2010	DCX
10	Association between temporal lobe P-glycoprotein expr ession and seizure recurrence after surgery for pharmacoresistant temporal lobe epilepsy. (20403441)	Kwan P.... O'Brien T.J.	2010	ABCB1
11	Changes in the expression of selenoproteins in mesial temporal lobe epilepsy patients. (19499324)	YA1zbaA9ioA9lu A.... OzgA1As M.	2009	GPX1, SEPW1
12	Variants of the genes encoding AQP4 and Kir4.1 are as sociated with subgroups of patients with temporal lobe epilepsy. (19864112)	Heuser K.... Ottersen O.P.	2009	AQP4, KCNJ10
13	Interleukin-6 levels are increased in temporal lobe epilepsy but not in extra-temporal lobe epilepsy. (19252806)	Liimatainen S.... Peltola J.	2009	IL6
14	The mechanisms of medically refractory temporal lobe epilepsy. (19960958)	Chayasirisobhon S.	2009	ABCC1, ABCB1
15	Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsy. (19287316)	Kobow K.... BlA1mcke I.	2009	RELN
16	Lateral temporal lobe epilepsies: clinical and geneti c features. (19469848)	Michelucci R.... Nobile C.	2009	LGI1
17	Glycinergic tonic inhibition of hippocampal neurons with depolarizing GABAergic transmission elicits histopathological signs of temporal lobe epilepsy. (19210758)	Eichler S.A.... Meier J.C.	2008	SLC12A5
18	Comparative proteomics and correlated signaling network of rat hippocampus in the pilocarpine model of temporal lobe epilepsy. (18186018)	Liu X.Y.... Wei Y.Q.	2008	VDAC2, INA
19	M129V polymorphism in the prion protein gene is not associated with mesial temporal lobe epilepsy in a Han Chinese population. (18549399)	Wang X.... Liu Y.	2008	PRNP
20	Transcriptionally less active prodynorphin promoter alleles are associated with temporal lobe epilepsy: a case-control study and meta-analysis. (18334734)	Kauffman M.A.... Kochen S.	2008	PDYN
21	Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. (17931873)	Ravizza T.... Vezzani A.	2008	IL1B
22	The NR1 N-methyl-D-aspartate subunit and brain-derived neurotrophic factor in temporal lobe epilepsy hippocampus: a comparison of patients with and without coexisting psychiatric symptoms. (17919302)	Toro C.T.... Deakin J.F.	2007	GRIN1
23	5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression. (17588547)	Hasler G.... Theodore W.H.	2007	HTR1A
24	Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy. (17855601)	Huberfeld G.... Rivera C.	2007	SLC12A5
25	Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy. (16121124)	Schindler C.K.... Henshall D.C.	2006	CASP3, ENDOG, DFFB
26	Epileptogenic roles of astroglial death and regenerat ion in the dentate gyrus of experimental temporal lobe epilepsy. (16845674)	Kang T.C.... Kwon O.S.	2006	GLUD1
27	Architectural (Type IA) focal cortical dysplasia and parvalbumin immunostaining in temporal lobe epilepsy. (16822257)	Garbelli R.... Spreafico R.	2006	PVALB
28	Aberrant expression of cytoskeleton proteins in hippocampus from patients with mesial temporal lobe epilepsy. (16583313)	Yang J.W.... Lubec G.	2006	TCP1, STIP1, SIRT2
29	The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy. (16928449)	Brandt C.... LAPscher W.	2006	ABCB1
30	THE SCN2A gene is not a likely candidate for familial mesial temporal lobe epilepsy. (16914293)	Maurer-Morelli C.V.... Lopes-Cendes I.	2006	SCN2A
31	Analysis of pThr286-CaMKII and CaMKII immunohistochemistry in the hippocampus of patients with temporal lobe epilepsy. (16207525)	Lie A.A.... Elger C.E.	2005	CAMK2G
32	Reduction of hippocampal collapsin response mediated protein-2 in patients with mesial temporal lobe epilepsy. (15672539)	Czech T.... Lubec G.	2004	DPYSL2
33	Neurotrophin receptor immunoreactivity in the hippocampus of patients with mesial temporal lobe epilepsy. (15541005)	Ozbas-GerAseker F.... Aronica E.	2004	NTRK1, NGFR
34	Mesial temporal lobe epilepsy: a proton magnetic resonance spectroscopy study and a histopathological analysis. (15481715)	Cohen-Gadol A.A.... Hetherington H.H.	2004	GFAP
35	Limbic reductions of 5-HT1A receptor binding in human temporal lobe epilepsy. (15111672)	Savic I.... Farde L.	2004	HTR1A
36	Statistical parametric mapping of 5-HT1A receptor binding in temporal lobe epilepsy with hippocampal ictal onset on intracranial EEG. (15193619)	Merlet I.... MauguiA"re F.	2004	HTR1A
37	Increased frequency of interleukin-1beta-511T allele in patients with temporal lobe epilepsy, hippocampal sclerosis, and prolonged febrile convulsion. (12790892)	Kanemoto K.... Nishimura M.	2003	IL1B
38	GABA(B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsy. (12601092)	Gambardella A.... Quattrone A.	2003	GABBR1, GABRB1
39	PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy. (12629228)	Toczek M.T.... Theodore W.H.	2003	HTR1A
40	A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy. (11835385)	Stogmann E.... Zimprich F.	2002	PDYN
41	Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy. (12399076)	Seegers U.... LAPscher W.	2002	ABCB1
42	Glutamate NMDA receptor subunit R1 and GAD mRNA expression in human temporal lobe epilepsy. (12585688)	Neder L.... Moreira J.E.	2002	GAD1
43	Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. (10611117)	Proper E.A.... De Graan P.N.	2000	GFAP, GAP43
44	APOE epsilon4 genotype is associated with an earlier onset of chronic temporal lobe epilepsy. (10932283)	Briellmann R.S.... Berkovic S.F.	2000	APOE
45	Lack of association between temporal lobe epilepsy and a novel polymorphism in the alpha 2 subunit gene (ATP1A2) of the sodium potassium transporting ATPase. (10686557)	Buono R.J.... Berrettini W.H.	2000	ATP1A2
46	Expression of 5alpha-reductase and 3alpha-hydroxisteroid oxidoreductase in the hippocampus of patients with chronic temporal lobe epilepsy. (10691110)	Stoffel-Wagner B.... Elger C.E.	2000	SRD5A1
47	Serum sex hormones are altered in patients with chronic temporal lobe epilepsy receiving anticonvulsant medication. (9821980)	Stoffel-Wagner B.... Elger C.E.	1998	SHBG
48	Altered hippocampal kainate-receptor mRNA levels in temporal lobe epilepsy patients. (9848088)	Mathern G.W.... Adelson P.D.	1998	GRIK1, GRIK2, GRIK5
49	The apolipoprotein E epsilon 4 allele is not associated with early onset temporal lobe epilepsy. (9175120)	Blumcke I.... Wiestler O.D.	1997	APOE
50	Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. (7472396)	Du F.... Schwarcz R.	1995	PVALB

Genes related to temporal lobe epilepsy according to GeneCards:

(show top 50)    (show all 182)

id	Symbol	Description	Score	GeneCards Section Context
1	ACOT7	acyl-CoA thioesterase 7	11.1	Summaries, Publications
2	RELN	reelin	11.1	Summaries, Publications
3	CASP2	caspase 2, apoptosis-related cysteine peptidase	11.1	Summaries, Publications
4	ETL2	epilepsy, familial temporal lobe	11.0	Publications
5	LGI1	leucine-rich, glioma inactivated 1	11.0	Publications
6	LGI4	leucine-rich repeat LGI family, member 4	11.0	Publications
7	CALHM1	calcium homeostasis modulator 1	11.0	Publications
8	GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	11.0	Publications
9	SEPW1	selenoprotein W, 1	11.0	Publications
10	PFN2	profilin 2	11.0	Publications
11	PCOLCE	procollagen C-endopeptidase enhancer	11.0	Publications
12	OPALIN	oligodendrocytic myelin paranodal and inner loop protein	11.0	Publications
13	HLA-S	major histocompatibility complex, class I, S (pseudogene)	11.0	Publications
14	MIR146A	microRNA 146a	11.0	Publications
15	C19orf48	chromosome 19 open reading frame 48	11.0	Publications
16	LGI3	leucine-rich repeat LGI family, member 3	11.0	Publications
17	PDYN	prodynorphin	11.0	Publications
18	TSPO	translocator protein (18kDa)	11.0	Publications
19	SCG2	secretogranin II	11.0	Publications
20	CCNI	cyclin I	11.0	Publications
21	VDAC2	voltage-dependent anion channel 2	11.0	Publications
22	CHGB	chromogranin B (secretogranin 1)	11.0	Publications
23	LGI2	leucine-rich repeat LGI family, member 2	11.0	Publications
24	SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5	11.0	Publications
25	CLEC3B	C-type lectin domain family 3, member B	11.0	Publications
26	CACNB1	calcium channel, voltage-dependent, beta 1 subunit	11.0	Publications
27	BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	11.0	Publications
28	DBP	D site of albumin promoter (albumin D-box) binding protein	11.0	Publications
29	SLC38A2	solute carrier family 38, member 2	11.0	Publications
30	PRDX3	peroxiredoxin 3	11.0	Publications
31	SCN1B	sodium channel, voltage-gated, type I, beta subunit	11.0	Publications
32	GRM2	glutamate receptor, metabotropic 2	11.0	Publications
33	GRIK5	glutamate receptor, ionotropic, kainate 5	11.0	Publications
34	KLK1	kallikrein 1	11.0	Publications
35	FAM3C	family with sequence similarity 3, member C	11.0	Publications
36	INA	internexin neuronal intermediate filament protein, alpha	11.0	Publications
37	KCNJ10	potassium inwardly-rectifying channel, subfamily J, member 10	11.0	Publications
38	ENDOG	endonuclease G	11.0	Publications
39	SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	11.0	Publications
40	AQP4	aquaporin 4	11.0	Publications
41	STIP1	stress-induced-phosphoprotein 1	11.0	Publications
42	CNP	2',3'-cyclic nucleotide 3' phosphodiesterase	11.0	Publications
43	ASIC1	acid-sensing (proton-gated) ion channel 1	11.0	Publications
44	SCN3B	sodium channel, voltage-gated, type III, beta subunit	11.0	Publications
45	SIRT2	sirtuin 2	11.0	Publications
46	CA1	carbonic anhydrase I	11.0	Publications
47	MOG	myelin oligodendrocyte glycoprotein	11.0	Publications
48	OPRL1	opiate receptor-like 1	11.0	Publications
49	IL1RL2	interleukin 1 receptor-like 2	11.0	Publications
50	PNOC	prepronociceptin	11.0	Publications

Pathways related to temporal lobe epilepsy according to GeneDecks:

(show top 50)    (show all 65)

id	Pathway	Score	Top Affiliating Genes
1	Class A/1 (Rhodopsin-like receptors)38	10.8	NPY1R, NPY, CXCR1, OPRL1, PDYN, PNOC
2	Axon guidance38	10.6	PRNP, DCX, STIP1, DPYSL2, RHOA, CACNB2
3	Ca, cAMP and Lipid Signaling3	10.5	SLC12A2, CAMK2G, CALB1, GNB3, HTR1A, APOA1
4	Benzodiazepine Pathway, Pharmacodynamics34	10.5	TSPO, SLC6A1, GABRB2, SLC6A11
5	GPCR ligand binding38	10.5	GRM5, GRM4, GRM3, GRM2, GRM1
6	GABA signaling in brain10	10.4	SLC6A11, GAD2, GABRB3, GABRA5, GAD1, GABRB2
7	Development_MAG-dependent inhibition of neurite outgrowth41	10.3	RTN4, PSEN2, RHOA, NGFR, NGF, NTRK2
8	Development MAG-dependent inhibition of neurite outgrowth10	10.3	RTN4, RHOA, NGFR, NGF, NTRK2, NTRK1
9	Neurotrophin signaling pathway20	10.3	PSEN2, RHOA, NGFR, NGF, NTRK2, NTRK1
10	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	10.2	SLC6A4, HTR1A, MAOA
11	Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling41	10.2	PDYN, GABRB1, GABRB2, GABRB3, GRM1, GRIN2B
12	Long-term potentiation20	10.1	CAMK2G, GRM5, GRM1, GRIN2B, GRIN2A, GRIN1
13	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling10	10.1	GABRB3, GABRB2, GABRB1, GRM1, GRIN2B, GRIN2A
14	Dopamine-DARPP32 Feedback onto cAMP Pathway36	10.0	GRIN2B, GNB3, CACNB1, CACNB2, NOS1, GRIN2A
15	Doxorubicin Pathway, Pharmacokinetics34	9.9	SOD1, ABCC1, ABCB1, NOS1, GPX1
16	Signaling in Gap Junctions36	9.9	GJB1, GJA1, GNB3, HTR2C, GRM5, GRM4
17	Glutamatergic synapse20	9.9	GRIK2, SLC38A2, GRIK5, GRIN1, GRIN2A, GRIN2B
18	Long-term depression20	9.8	NOS1, CRH, GRM5, GRM1, GRIA3, GRIA2
19	Development_Neurotrophin family signaling41	9.8	TP53, NTF3, NTRK1, NTRK2, NGF, NGFR
20	Development Neurotrophin family signaling10	9.8	NGFR, BDNF, TP53, NTF3, NTRK1, NTRK2
21	Glutamic acid signaling10	9.7	GRIA3, GRIK1, GRIK2, GRIK5, GRIN1, GRIN2A
22	Neuropathic Pain-Signaling in Dorsal Horn Neurons36	9.7	NTRK2, NOS1, PDYN, CAMK2G, GRM5, GRM4
23	Akt Signaling36	9.7	NGFR, GABRB1, GABRB2, GABRA5, GABRB3, NTF3
24	Prion diseases20	9.6	SOD1, PRNP, STIP1, IL6, IL1B, IL1A
25	CREB Pathway36	9.6	GRM4, GRM5, GNB3, CACNB1, CACNB2, NTF3
26	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	9.6	SOD1, ABCC1, ABCB1, TP53, GPX1
27	Alzheimers disease20	9.5	PSEN2, NDUFS4, NOS1, TNFRSF1A, ERN1, CASP3
28	PAK Pathway36	9.5	NTF3, CASP2, CASP6, CASP3, CCL3, CCL4
29	Apoptosis through Death Receptors36	9.5	DFFB, NGFR, DAPK1, TNFRSF1A, TP53, CASP2
30	DHA Signaling36	9.4	NTF3, NTRK1, NTRK2, NGFR, CASP2, CASP6
31	Selected targets of ESR110	9.3	SLC12A2, SLC1A2, SLC1A1, SOD1, ABCB1, CTSD
32	PEDF Induced Signaling36	9.3	CCL3, CCL4, IL6, IL1B, IL1A, GRIN2B
33	Apoptosis20	9.3	DFFB, NGF, NTRK1, TNFRSF1A, TP53, CASP6
34	Pathogenesis of ALS36	9.2	GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B
35	Selected targets of p5310	9.2	DKK1, ABCB1, CTSD, DAPK1, TP53, CASP6
36	Neuroscience3	9.2	CNP, NOS1, NGF, NGFR, GFAP, DPYSL2
37	JNK Pathway36	9.2	NTF3, NTRK1, NTRK2, NGFR, TNFRSF1A, TP53
38	Apoptotic Pathways in Synovial Fibroblasts36	9.1	NGFR, NTRK2, NTRK1, NTF3, TNFRSF1A, TP53
39	JAK-STAT Pathway36	9.1	NTF3, NTRK1, NTRK2, NGFR, PSMC2, PRL
40	Intracellular Calcium Signaling36	9.0	HTR1A, HTR1B, HTR2C, GNB3, CACNB1, CACNB2
41	Mitochondrial Apoptosis36	9.0	TP53, NTF3, NTRK1, NTRK2, NGFR, CASP3
42	Neuroactive ligand-receptor interaction20	8.9	TSPO, PRL, OPRL1, NPY1R, ADORA1, GABBR1
43	Amyotrophic lateral sclerosis (ALS)20	8.9	TP53, TNFRSF1A, NOS1, SOD1, SLC1A2, CASP3
44	Cellular Apoptosis Pathway36	8.9	TP53, TNFRSF1A, NTF3, NTRK1, NTRK2, NGFR
45	p53 Mediated Apoptosis36	8.9	NGFR, NTRK2, NTRK1, NTF3, TP53, CASP6
46	Huntingtons disease20	8.8	SOD1, NDUFS4, TP53, CASP3, GPX1, GRM5
47	Endothelin-1 Signaling Pathway36	8.8	NOS1, NTRK2, NTRK1, CASP2, CASP6, CASP3
48	MAPK signaling pathway20	8.7	NGF, NTRK2, NTRK1, NTF3, TNFRSF1A, TP53
49	Molecular Mechanisms of Cancer36	8.7	PSEN2, NTRK2, NTF3, TP53, CAMK2G, CASP6
50	p38 Signaling36	8.3	CASP6, TP53, TNFRSF1A, NTF3, NTRK1, NTRK2

Compounds related to temporal lobe epilepsy according to GeneDecks:

(show top 50)    (show all 397)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.6	SCG2, S100B, MKI67, GRM3, CCNA2, CALB1
2	chloride32	10.5	CLU, MSN, INTS2, GRM1, GRM3, AQP4
3	nicotine32 34 9 9	13.5	CRH, PDYN
4	gnrh32	10.1	SCG2, MKI67, HTR2C, CAMK2G, CYP11A1, SRD5A1
5	catecholamine32	10.0	BDNF, CHGB, CHGA, S100B, IL1RAPL2, ENO2
6	haloperidol32 34 9 9	13.0	BDNF, CHGA, GRIN2B, GRM5, MAOB, HTR1A
7	choline32 9 18 9	13.0	S100B, APOA1, ENO2, MAP2, MAOB, CALB1
8	levodopa32 9 9	11.7	CNR1, BDNF, CHGA, MAOA, MAOB, HTR1A
9	atp32	9.7	VDAC2, CLU, BDNF, SCG2, IL1RAPL2, IL1RN
10	L-Glutamic Acid9 18 9	11.5	GRIA1, GRIA2, GRIA3, GRIK1, GRIK2, GRIK5
11	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid32	9.5	BDNF, GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A
12	tetrodotoxin32	9.5	CNR1, BDNF, APOE, ENO2, CALB1, CAMK2G
13	ethanol32 34 9 18 9	13.4	CLU, BDNF, S100B, MKI67, GRIN1, GRIN2A
14	potassium32 9 18 9	12.4	BDNF, BCL2L11, KCND2, SCN1B, SCN1A, LGI1
15	acetylcholine32 9 18 9	12.2	CNR1, BDNF, SCG2, CHGA, S100B, MOG
16	progesterone32 42 9 18 9	13.2	CLU, CHGA, S100B, MAP2, CCL4, CCNA2
17	h2o232	9.2	CLU, BDNF, BCL2L11, INTS2, IL1RAPL2, IL1RN
18	cyclic amp32 18	10.1	CNR1, BDNF, SCG2, CHGA, GRM2, GRM3
19	kainate32	9.0	CNR1, CLU, BDNF, KARS, GRIA1, GRIA2
20	aspartate32	8.9	CNR1, GC, BDNF, S100B, MMP9, GRM1
21	cysteine32	8.9	SEPW1, CLU, SCG2, S100B, KARS, MMP9
22	5-hydroxytryptamine32	8.9	CNR1, SCG2, CHGA, IL1A, IL1RAPL2, ENO2
23	histamine32 18	9.9	CNR1, BDNF, SCG2, CHGA, IL1B, IL1RAPL2
24	cocaine32 9 9	10.9	CNR1, BDNF, S100B, GRIA1, GRIA2, GRIN1
25	oxygen32 18	9.8	CLU, BDNF, BCL2L11, MOG, INTS2, GRIN1
26	fluoxetine32 34 9 9	11.8	CNR1, BDNF, MAOA, MAOB, HTR1A, HTR1B
27	forskolin32 42 9 9	11.8	CNP, BDNF, SCG2, CHGA, S100B, GRIA1
28	adenylate32	8.7	CNP, CNR1, GC, BDNF, SCG2, CHGA
29	superoxide32 18	9.6	GC, CLU, SCG2, IL1B, IL1RAPL2, IL1RN
30	alanine32	8.6	CNR1, BCL2L11, S100B, MSN, KARS, MMP9
31	paraffin32	8.6	CLU, CHGA, S100B, MMP9, MKI67, MDM2
32	phosphatidylinositol32	8.2	RELN, RDX, BDNF, BCL2L11, MSN, MMP9
33	cholesterol32 9 18 9	11.2	RELN, GC, CLU, BDNF, CHGA, IL1RAPL2
34	lipid32	8.1	RELN, CNP, CNR1, RDX, GC, CLU
35	paclitaxel32 34 9 9	11.0	CLU, BDNF, BCL2L11, CHGA, S100B, MKI67
36	estrogen32	8.0	RDX, GC, CLU, BDNF, CHGB, CHGA
37	dopamine32 9 18 9	11.0	CLU, BDNF, SCG2, CHGB, S100B, MMP9
38	cyclosporin a32 42	8.9	S100B, MMP9, IL1A, IL1RAPL2, IL1RN, IL6
39	glutamate32	7.9	CNP, CNR1, GC, CLU, ATP1A2, KARS
40	lactate32	7.8	CLU, BDNF, CHGA, S100B, MMP9, ASIC1
41	nmda32 42	8.7	RELN, CNR1, BDNF, KARS, GRIA1, GRIA2
42	indomethacin32 9 9	9.7	CNR1, BDNF, IL1A, IL1B, IL1RAPL2, IL1RN
43	testosterone32 9 18 9	10.3	GC, CLU, BDNF, CHGA, S100B, MMP9
44	gaba32 42	8.2	RELN, CNR1, BDNF, CHGA, S100B, KARS
45	dexamethasone32 42 34 9 9	11.1	CLU, CLEC3B, BCL2L11, SCG2, CHGB, CHGA
46	calcium32 9 18 9	10.1	RELN, CNR1, RDX, PCOLCE, CLEC3B, BDNF
47	actinomycin d32	6.8	CLU, BDNF, BCL2L11, MMP9, IL1A, IL1B
48	norepinephrine32 9 18 9	9.8	CNR1, BDNF, SCG2, CHGB, CHGA, S100B
49	vegf32	5.9	SEMA3A, CLU, BDNF, SCG2, CHGA, S100B
50	retinoic acid32 42 18	6.6	GC, SEPT3, CLU, BDNF, CHGA, S100B

Cellular components related to temporal lobe epilepsy according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:030424	10.5	PVALB, NPY1R, SLC6A1, GAP43, GAD2, TNFRSF1A
2	dendrite	GO:030425	10.4	GABRA5, DCX, DPYSL2, CALB1, APOE, GRIN1
3	voltage-gated sodium channel complex	GO:001518	10.4	SCN3B, SCN1A, SCN2A, SCN1B
4	synapse	GO:045202	10.3	SLC1A3, TLN2, NOS1, GRIN1, ATP1A2, LGI1
5	dendritic spine	GO:043197	10.2	GABBR1, SLC1A3, NOS1, GRIN1, GRIA1, ATP1A2
6	perikaryon	GO:043204	10.2	SLC12A5, CYP11A1, ENO2, GRIK5, GRIK2, GRIA3
7	basolateral plasma membrane	GO:016323	10.0	ADORA1, SLC12A2, SLC4A4, SLC1A3, ABCC1, EZR
8	postsynaptic density	GO:014069	9.9	ADORA1, NTRK2, GRM3, GRM1, GRIN2B, GRIN2A
9	neuronal cell body	GO:043025	9.9	SOD1, SLC1A3, RTN4, ADORA1, GABBR1, DPYSL2
10	terminal button	GO:043195	9.8	ADORA1, DPYSL2, NTRK2, GRIN2B, GRIN2A, GRIN1
11	cell surface	GO:009986	9.6	NTRK1, NTRK2, NGFR, ABCB1, SLC1A3, SLC6A1
12	postsynaptic membrane	GO:045211	9.4	ADORA1, GABBR1, GABBR2, GABRB1, GABRB2, GABRA5
13	presynaptic membrane	GO:042734	9.2	GAD2, GABBR1, ADORA1, GRM3, GRM2, GRM1
14	cell junction	GO:030054	8.6	RHOA, TCP1, GABBR1, GABBR2, GABRB1, GABRB2
15	extracellular space	GO:005615	8.2	CTSD, TNFRSF1A, CCL3, CCL4, APOE, CRH
16	extracellular region	GO:005576	8.2	PNOC, NTF3, CTSD, TNFRSF1A, CCL3, CCL4
17	integral to plasma membrane	GO:005887	8.1	CNR1, KCNJ10, SCN2A, ASIC1, GRIA2, GRIK1
18	cytosol	GO:005829	7.0	DPYSL2, GFAP, ACOT7, EIF2S1, RHOA, NGFR
19	plasma membrane	GO:005886	5.7	SLC6A1, GABRB3, GAD2, SLC6A11, GABRA5, GAP43

Biological processes related to temporal lobe epilepsy according to GeneDecks:

(show top 50)    (show all 59)

id	Name	GO ID	Score	Top Affiliating Genes
1	sodium ion transport	GO:006814	10.8	SLC12A2, SLC38A2, ASIC1, ATP1A2, SCN3B, SCN1A
2	nervous system development	GO:007399	10.8	ADORA1, DCX, DPYSL2, NTF3, SPAST, TMOD2
3	neurotransmitter secretion	GO:007269	10.8	SLC6A11, GAD2, GAD1, SLC38A2, SLC6A1, ABAT
4	axon guidance	GO:007411	10.8	NTF3, NGFR, RHOA, DPYSL2, STIP1, DCX
5	D-aspartate import	GO:070779	10.7	SLC1A2, SLC1A1, SLC1A3
6	behavior	GO:007610	10.7	NPY, ABAT, HTR1A, CCL3, MAOA, CNR1
7	response to cocaine	GO:042220	10.6	SLC6A1, CNR1, GRIN2A, GRIN2B, HTR1B, DPYSL2
8	regulation of axonogenesis	GO:050770	10.6	GRIN1, NGF, NGFR, RHOA, RTN4
9	sensory perception of pain	GO:019233	10.6	NPY1R, NGF, GRM1, GRIN2A, GRIN1, SCN3B
10	mechanoreceptor differentiation	GO:042490	10.6	BDNF, NTF3, NTRK1, NTRK2
11	response to toxin	GO:009636	10.5	SLC6A4, SLC6A1, GPX1, CCL3, CCL4, MAOB
12	regulation of sensory perception of pain	GO:051930	10.4	GRIN2A, GRM1, IL1A, CCL3, RTN4, KCNJ10
13	response to fungicide	GO:060992	10.4	SRD5A1, CYP11A1, GRIN2B, GRIN2A, GRIA3, GRIA2
14	long-term memory	GO:007616	10.4	RELN, GRIA1, GRIN1, GRIN2B, CRH
15	regulation of synaptic transmission	GO:050804	10.4	NTF3, GRM3, GRIK2, RELN
16	transmembrane transport	GO:055085	10.4	SLC38A2, SLC12A2, SLC12A5, GABRB1, GABRB2, GABRA5
17	response to nicotine	GO:035094	10.3	GABBR1, ABAT, NGF, MMP9, CNR1
18	cerebral cortex development	GO:021987	10.3	NPY, NTRK2, SRD5A1, GRIN2B, GRIN2A, GRIN1
19	learning or memory	GO:007611	10.3	CRH, TMOD2, CALB1, GRIN2B, GRIN2A, S100B
20	positive regulation of synaptic transmission	GO:050806	10.3	SLC1A3, GRIN2B, GRIK2, LGI1
21	glutamate catabolic process	GO:006538	10.3	GLUD1, GLUL, GAD1
22	neurotransmitter biosynthetic process	GO:042136	10.3	GAD2, GAD1, NOS1, MAOA
23	regulation of excitatory postsynaptic membrane potential	GO:060079	10.2	ADORA1, GRIN2B, GRIN2A, GRIN1, GRIK5, GRIK2
24	cellular response to organic substance	GO:071310	10.2	CASP3, CALB1, MAP2, IL1B, CLEC3B
25	feeding behavior	GO:007631	10.2	NPY1R, NPY, CRH, NTRK2, HTR2C, BDNF
26	regulation of long-term neuronal synaptic plasticity	GO:048169	10.2	GRIN2B, GRIN2A, GRIN1, GRIK2, KCNJ10
27	memory	GO:007613	10.2	SLC6A4, PSEN2, NGF, IL1RN, IL1B, GRIN2A
28	ion transmembrane transport	GO:034220	10.1	ATP1A2, GJA1, GABRB1, GABRB2, GABRA5, GABRB3
29	glutamate receptor signaling pathway	GO:007215	10.1	GRIN2B, GRIN2A, GRIK2, GRIK1, GRIA3
30	response to amphetamine	GO:001975	10.1	SOD1, DPYSL2, GRIN2B, GRIN2A, GRIN1
31	response to wounding	GO:009611	10.0	GAP43, SLC1A3, GFAP, NGFR, CASP3, GRIN2A
32	induction of apoptosis by extracellular signals	GO:008624	10.0	ADORA1, PSEN2, NGFR, NGF, DAPK1, TNFRSF1A
33	central nervous system development	GO:007417	9.8	DCX, NGFR, TP53, IL1RAPL2, GRIK1, MOG
34	response to gamma radiation	GO:010332	9.8	CYP11A1, TP53, CASP6, GPX1, IL1B, IL1A
35	nerve growth factor receptor signaling pathway	GO:048011	9.8	RTN4, PSEN2, RHOA, NGFR, NGF, NTRK2
36	response to ethanol	GO:045471	9.8	GABBR1, SOD1, ABAT, TNFRSF1A, HTR1B, MAOB
37	regulation of blood pressure	GO:008217	9.8	NPY1R, SOD1, ACE, GNB3, ATP1A2, CHGA
38	positive regulation of axonogenesis	GO:050772	9.7	RHOA, NGFR, NGF, NTRK2
39	response to estradiol stimulus	GO:032355	9.7	SLC6A4, SLC6A1, NPY1R, ESR1, CASP6, ENO2
40	response to hypoxia	GO:001666	9.7	ADORA1, SLC6A4, PSEN2, ABAT, NOS1, TNFRSF1A
41	negative regulation of neuron apoptotic process	GO:043524	9.7	SOD1, PRDX3, RHOA, NGF, NTRK2, NTRK1
42	transport	GO:006810	9.5	ABCC1, SLC6A1, SLC4A4, SLC12A2, SLC12A5, GABRB1
43	inflammatory response	GO:006954	9.4	ADORA1, C3, CXCR1, NGF, CRH, TNFRSF1A
44	positive regulation of apoptotic process	GO:043065	9.4	SOD1, TSPO, TP53, CASP2, ENDOG, IL1B
45	anti-apoptosis	GO:006916	9.4	SOD1, PRNP, NGFR, NGF, DAPK1, GPX1
46	apoptotic process	GO:006915	9.0	DAPK1, PLEC, NGF, NGFR, TSPO, DFFB
47	response to drug	GO:042493	9.0	SLC6A11, IL1RN, GRIN2A, MMP9, BDNF, ENO2
48	synaptic transmission	GO:007268	8.7	SLC6A11, GAD2, GABRB3, GABRA5, GAD1, GABRB2
49	locomotory behavior	GO:007626	INF	NPY1R, SOD1, , ABAT, CALB1, GRM1
50	sensory perception of sound	GO:007605	INF	GABRA5, GABRB2, SLC1A3, SOD1, , CASP3

Molecular functions related to temporal lobe epilepsy according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	glutamate decarboxylase activity	GO:004351	10.4	GLUL, GAD1, GAD2
2	calcium channel regulator activity	GO:005246	10.4	GRM2, GRM3, CACNB2, NPY
3	serotonin binding	GO:051378	10.3	HTR2C, HTR1B, HTR1A, MAOA
4	neurotransmitter binding	GO:042165	10.3	GRIN1, GRIN2A, GRIN2B, SLC6A11
5	glutamate receptor activity	GO:008066	10.3	GRM5, GRM4, GRM3, GRM2, GRM1, GRIA2
6	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	GO:004971	10.2	GRIA3, GRIA2, GRIA1
7	kainate selective glutamate receptor activity	GO:015277	10.2	GRIK5, GRIK2, GRIK1, GRIA2, GRIA1
8	extracellular-glutamate-gated ion channel activity	GO:005234	9.9	GRIA1, GRIN2B, GRIN2A, GRIN1, GRIK5, GRIK2
9	drug binding	GO:008144	9.6	ACE, HTR2C, HTR1B, HTR1A, GRIN2B, CNR1
10	identical protein binding	GO:042802	9.2	PRDX3, PRNP, TP53, ESR1, GLUL, GLUD1
11	protein binding	GO:005515	5.2	NLRP12, NGFR, PFN2, RHOA, ABCB1, EIF2S1