MCID: TMP001
MIFTS: 62

Temporal Lobe Epilepsy malady

Genetic diseases, Neuronal diseases, Rare diseases categories
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Summaries for Temporal Lobe Epilepsy

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65Wikipedia, 33MalaCards
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Wikipedia:65 Temporal lobe epilepsy is a chronic neurological condition characterized by recurrent seizures... more...

MalaCards: Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to febrile seizures and frontal lobe epilepsy. An important gene associated with Temporal Lobe Epilepsy is CASP2 (caspase 2, apoptosis-related cysteine peptidase), and among its related pathways are Interaction between L1 and Ankyrins and Neuroscience. The drugs mephenytoin and phenytoin and the compounds dodecylphosphocholine and dimyristoylphosphatidylcholine have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and cortex, and related mouse phenotypes are adipose tissue and mortality/aging.

Aliases & Classifications for Temporal Lobe Epilepsy

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8Disease Ontology, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

temporal lobe epilepsy 8 31
epilepsy, temporal lobe 8 62
epilepsy temporal lobe 45


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Disease Ontology8 DOID:3328
MeSH35 D004833

Related Diseases for Temporal Lobe Epilepsy

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17GeneCards, 18GeneDecks
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Diseases in the Epilepsy, Familial Temporal Lobe, 1 family:

temporal lobe epilepsy Epilepsy, Familial Temporal Lobe, 5
Epilepsy, Familial Temporal Lobe, 6 Epilepsy, Familial Temporal Lobe, 4
Epilepsy, Familial Temporal Lobe, 2

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1febrile seizures31.2SCN1A, LGI1, SCN1B
2frontal lobe epilepsy30.9SCN1B, SCN1A
3encephalitis30.8PDYN, TSPO, LGI1
4memory impairment30.7HTR1A, TSPO, APOE, PDYN
5idiopathic generalized epilepsy30.6SCN1B, LGI1
6juvenile myoclonic epilepsy30.6SCN1A, GABBR1
7mood disorder30.5RELN, HTR1A, GABBR1, PDYN
8psychotic disorder30.3RELN, HTR1A, PDYN
9obsessive-compulsive disorder30.3PDYN, TSPO, HTR1A
10dementia30.3HTR1A, APOE, TSPO
11schizophrenia30.2GABBR1, TSPO, PDYN, HTR1A, RELN
12epilepsy syndrome29.9GABBR1, SCN1A, HTR1A, PDYN, CASP2, LGI1
13mesial temporal lobe epilepsy with hippocampal sclerosis10.9
14neuronitis10.9
15status epilepticus10.7
16cerebritis10.6
17autosomal dominant partial epilepsy with auditory features10.5
18encephalocele10.5
19limbic encephalitis10.5
20encephaloceles10.5
21syncope10.5
22epilepsy, familial temporal lobe, 110.5
23benign familial mesial temporal lobe epilepsy10.5
24parametritis10.4
25chorea-acanthocytosis10.4
26acanthocytosis10.4
27temporal epilepsy, familial10.4
28chorea10.4
29transvestism10.3
30tetanus10.3
31autonomic dysfunction10.3
32seizure disorder10.3
33infantile-onset mesial temporal lobe epilepsy with severe cognitive regression10.3
34dysembryoplastic neuroepithelial tumor10.2
35major depressive disorder10.2
36choroid plexus papilloma10.2
37capgras syndrome10.2
38myxopapillary ependymoma10.2
39ganglioglioma10.2
40choroiditis10.2
41cysticercosis10.2
42eclampsia10.2
43alexia10.2
44asperger syndrome10.2
45periventricular nodular heterotopia10.2
46systemic lupus erythematosus10.2
47arachnoiditis10.2
48west syndrome10.2
49insulinoma10.2
50cerebral malaria10.2

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to temporal lobe epilepsy

Symptoms for Temporal Lobe Epilepsy

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Drugs & Therapeutics for Temporal Lobe Epilepsy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Temporal Lobe Epilepsy

Search NIH Clinical Center for Temporal Lobe Epilepsy

Inferred drug relations via UMLS62/NDF-RT41:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Genetic Tests for Temporal Lobe Epilepsy

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Anatomical Context for Temporal Lobe Epilepsy

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33MalaCards
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MalaCards organs/tissues related to Temporal Lobe Epilepsy:

33
Temporal lobe, Brain, Cortex, Bone, Amygdala, Testes, Heart, Cerebellum, Prefrontal cortex, Olfactory bulb, Skin

Animal Models for Temporal Lobe Epilepsy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7PDYN, ACOT7, APOE, LGI1, GABBR1
2MP:00107687.8SCN1A, SCN1B, GABBR1, RELN, LGI1, HTR1A
3MP:00053787.3GABBR1, PDYN, LGI1, RELN, APOE, ACOT7
4MP:00053867.2ACOT7, HTR1A, SCN1A, RELN, APOE, PDYN
5MP:00036316.6SCN1A, GABBR1, PDYN, CALHM1, CASP2, ACOT7

Publications for Temporal Lobe Epilepsy

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52PubMed
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Articles related to Temporal Lobe Epilepsy:

(show top 50)    (show all 797)
idTitleAuthorsYear
1
Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy. (23398413)
2013
2
Defining "epileptogenesis" and identifying "antiepileptogenic targets" in animal models of acquired temporal lobe epilepsy is not as simple as it might seem. (22342985)
2013
3
Impaired and facilitated functional networks in temporal lobe epilepsy. (24073391)
2013
4
P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study. (23786896)
2013
5
Characteristics of temporal lobe epilepsy with no ictal impairment of consciousness. (23369403)
2013
6
Functional connectivity estimated from intracranial EEG predicts surgical outcome in intractable temporal lobe epilepsy. (24205027)
2013
7
The strange sensation of deja vu: not so strange in temporal lobe epilepsy. (23457224)
2013
8
Application of dynamic susceptibility contrast-enhanced perfusion in temporal lobe epilepsy. (23117196)
2013
9
Subtle temporal lobe epilepsy with headache as the major complaint: what can we learn from the long-delayed diagnosis? (23290451)
2013
10
Resting state networks in temporal lobe epilepsy. (24117098)
2013
11
Sleep modulation of epileptic activity in mesial and neocortical temporal lobe epilepsy: a study with depth and subdural electrodes. (23751358)
2013
12
Pearls & Oy-sters: ictal syncope in a patient with temporal lobe epilepsy. (24325018)
2013
13
Enhanced sequential reaction time task performance in a rat model of mesial temporal lobe epilepsy with classic hippocampal sclerosis. (23511251)
2013
14
Mesial temporal lobe epilepsy in a patient with spinocerebellar ataxia type 13 (SCA13). (23215817)
2013
15
Outcomes for temporal lobe epilepsy operations may not be equal: a call for an RCT of ATL vs SAH. (23553476)
2013
16
Whole mitochondrial DNA variations in hippocampal surgical specimens and blood samples with high-throughput sequencing: a case of mesial temporal lobe epilepsy with hippocampal sclerosis. (23872536)
2013
17
A more realistic approach, using dynamic stimuli, to test facial emotion recognition impairment in temporal lobe epilepsy. (23648274)
2013
18
Increased metallothionein I/II expression in patients with temporal lobe epilepsy. (23028585)
2012
19
Critically appraised topic. Temporal lobe epilepsy and hippocampal stimulation. (23041406)
2012
20
Pathophysiology of mood disorders in temporal lobe epilepsy. (23429849)
2012
21
Changes in interictal spike features precede the onset of temporal lobe epilepsy. (22718546)
2012
22
Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy. (22238156)
2012
23
Temporal Lobe Epilepsy and the BDNF Receptor, TrkB (22787630)
2012
24
Medial temporal lobe epilepsy is associated with neuronal fibre loss and paradoxical increase in structural connectivity of limbic structures. (22764263)
2012
25
Serious adverse effects of gamma knife radiosurgery for mesial temporal lobe epilepsy. (23269044)
2012
26
Mesial temporal sclerosis is linked with more widespread white matter changes in temporal lobe epilepsy. (24179742)
2012
27
Prominent oligodendroglial response in surgical specimens of patients with temporal lobe epilepsy. (23083461)
2012
28
State-dependent precursors of seizures in correlation-based functional networks of electrocorticograms of patients with temporal lobe epilepsy. (22271261)
2012
29
Aberrant glutamate receptor 5 expression in temporal lobe epilepsy lesions. (19941835)
2010
30
Functional variant in complement C3 gene promoter and genetic susceptibility to temporal lobe epilepsy and febrile seizures. (20862287)
2010
31
Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. (19864112)
2010
32
Changes in the expression of selenoproteins in mesial temporal lobe epilepsy patients. (19499324)
2009
33
Spatiotemporospectral characteristics of scalp ictal EEG in mesial temporal lobe epilepsy with hippocampal sclerosis. (19563787)
2009
34
Surgery for temporal lobe epilepsy after cerebral malaria. (18515154)
2008
35
A componential analysis of proverb interpretation in patients with frontal lobe epilepsy and temporal lobe epilepsy: relationships with disease-related factors. (17853125)
2008
36
A Kv4.2 truncation mutation in a patient with temporal lobe epilepsy. (16934482)
2006
37
Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy. (16121124)
2006
38
Lack of GABABR1 gene variation (G1465A) in a Chinese population with temporal lobe epilepsy. (16278087)
2005
39
Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy. (15694259)
2005
40
Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. (15057313)
2004
41
Perivascular clustering in temporal lobe epilepsy: oligodendroglial cells of unknown function. (15480711)
2004
42
Reduction of hippocampal collapsin response mediated protein-2 in patients with mesial temporal lobe epilepsy. (15672539)
2004
43
Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. (12122039)
2002
44
Inter-ictal and post-ictal psychoses in frontal lobe epilepsy: a retrospective comparison with psychoses in temporal lobe epilepsy. (10933987)
2000
45
Ultrastructural localization of dynorphin in the dentate gyrus in human temporal lobe epilepsy: a study of reorganized mossy fiber synapses. (10098940)
1999
46
Disturbance of visual information processing in temporal lobe epilepsy: in comparison with idiopathic generalized epilepsy. (8271589)
1993
47
MRI in the presurgical evaluation of patients with frontal lobe epilepsy and children with temporal lobe epilepsy: pathologic correlation and prognostic importance. (1563338)
1992
48
Developmental anterobasal temporal encephalocele and temporal lobe epilepsy. (2033453)
1991
49
Schizophrenia-like psychosis with Capgras syndrome in a patient with right temporal lobe epilepsy--a case report. (4095563)
1985
50
Transient global amnesia: manifestation of medial temporal lobe epilepsy. (455733)
1979

Variations for Temporal Lobe Epilepsy

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Expression for genes affiliated with Temporal Lobe Epilepsy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for genes affiliated with Temporal Lobe Epilepsy

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50PathCards, 55Reactome, 5Cell Signaling Technology, 53QIAGEN, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Temporal Lobe Epilepsy

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45Novoseek, 29IUPHAR, 61Tocris Bioscience, 11DrugBank, 3BitterDB, 24HMDB, 51PharmGKB
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Compounds related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1dodecylphosphocholine4510.3PDYN, APOE
2dimyristoylphosphatidylcholine4510.2PDYN, APOE
3damgo45 29 6112.2PDYN, GABBR1
4benzodiazepines4510.2TSPO, GABBR1
522r-hydroxycholesterol45 2911.2APOE, TSPO
6gamma-hydroxybutyrate4510.1TSPO, GABBR1
7baclofen45 1111.1TSPO, GABBR1
8nitrazepam45 1111.1SCN1A, TSPO
9bicuculline45 2911.1TSPO, GABBR1
10abecarnil4510.1HTR1A, TSPO
11carbon-114510.1HTR1A, TSPO
12benzodiazepine4510.0TSPO, GABBR1
13buspirone45 29 1112.0TSPO, HTR1A
14dopac4510.0SCG2, GABBR1
15clonazepam45 1111.0TSPO, GABBR1
16qx 314 chloride6110.0SCN1A, SCN1B
17tetrodotoxin citrate6110.0SCN1A, SCN1B
18phrixotoxin 36110.0SCN1A, SCN1B
19thiamine45 3 24 1113.0APOE, TSPO
20muscimol45 61 2912.0GABBR1, TSPO
21veratridine45 61 2912.0SCN1A, SCN1B
22scopolamine45 29 24 1112.9TSPO, HTR1A
23picrotoxin45 29 1111.9TSPO, GABBR1
24fluvoxamine45 51 1111.9TSPO, HTR1A
25pentylenetetrazol459.9TSPO, PDYN, GABBR1
26clomipramine45 51 1111.9HTR1A, TSPO
27naloxone45 29 51 1112.9TSPO, PDYN, GABBR1
28opiate459.9GABBR1, PDYN, TSPO
29cocaine45 1110.8GABBR1, PDYN, TSPO
30nicotine45 29 51 1112.8APOE, TSPO, PDYN
31tetrodotoxin45 61 2911.8SCN1A, SCN1B, APOE
32spec-t459.7TSPO, APOE
33l-tryptophan51 29 45 24 1113.7TSPO, HTR1A
34levodopa45 1110.7TSPO, HTR1A, PDYN
35amitriptyline45 29 51 1112.7GABBR1, HTR1A
36glutamine459.6APOE, TSPO, CASP2, PDYN
37morphine45 51 29 1112.6TSPO, CASP2, PDYN, GABBR1
38kainate45 2910.6APOE, TSPO, PDYN, GABBR1
39gaba459.6GABBR1, PDYN, RELN, TSPO
40glutamate459.3GABBR1, PDYN, RELN, TSPO, APOE
41gnrh459.3SCG2, PDYN, GABBR1
42zonisamide45 51 1111.3SCN1B, SCN1A
435-hydroxytryptamine459.2GABBR1, HTR1A, TSPO, SCG2
44cysteine459.1SCG2, APOE, CASP2, PDYN, GABBR1
45adenylate459.1GABBR1, PDYN, HTR1A, SCG2
46nmda45 299.9GABBR1, PDYN, HTR1A, RELN, TSPO, APOE
47norepinephrine45 24 1110.9GABBR1, PDYN, HTR1A, TSPO, SCG2
48potassium45 24 1110.9SCN1A, SCN1B, LGI1, CASP2, PDYN, GABBR1
49acetylcholine45 51 29 24 1112.7SCG2, APOE, TSPO, HTR1A, PDYN, GABBR1
50dopamine45 29 24 1111.6GABBR1, PDYN, HTR1A, TSPO, APOE, SCG2

GO Terms for genes affiliated with Temporal Lobe Epilepsy

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16Gene Ontology
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Cellular components related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:0015189.7SCN1B, SCN1A
2node of RanvierGO:0332689.7SCN1B, SCN1A
3intercalated discGO:0147049.6SCN1B, SCN1A
4T-tubuleGO:0303159.5SCN1B, SCN1A
5dendriteGO:0304259.4APOE, RELN, GABBR1
6extracellular regionGO:0055768.7GABBR1, PDYN, LGI1, APOE, SCN1B

Biological processes related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system axon regenerationGO:01401210.0TSPO, APOE
2regulation of behaviorGO:0507959.8HTR1A, RELN
3negative regulation of endothelial cell proliferationGO:0019379.7APOE, SCG2
4neuronal action potential propagationGO:0192279.7SCN1B, SCN1A
5agingGO:0075689.5APOE, TSPO, CASP2
6synaptic transmissionGO:0072688.5GABBR1, PDYN, TSPO, SCN1B

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle receptor bindingGO:0703269.7RELN, APOE
2voltage-gated sodium channel activityGO:0052489.6SCN1B, SCN1A

Products for genes affiliated with Temporal Lobe Epilepsy

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Sources for Temporal Lobe Epilepsy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet