MCID: TMP001
MIFTS: 57

Temporal Lobe Epilepsy malady

Summaries for Temporal Lobe Epilepsy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Temporal lobe epilepsy is a chronic neurological condition characterized by recurrent seizures... more...

MalaCards: Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to epilepsy syndrome and encephalitis. An important gene associated with Temporal Lobe Epilepsy is CASP2 (caspase 2, apoptosis-related cysteine peptidase). The drugs mephenytoin and phenytoin and the compounds glutamate and nmda have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and cortex, and related mouse phenotypes are nervous system and mortality/aging.

Aliases & Classifications for Temporal Lobe Epilepsy

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8Disease Ontology, 30LifeMap Discovery™, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

temporal lobe epilepsy 8 30
epilepsy, temporal lobe 8 60
epilepsy temporal lobe 44


External Ids:

Disease Ontology8 DOID:3328
MeSH34 D004833

Related Diseases for Temporal Lobe Epilepsy

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Epilepsy, Familial Temporal Lobe, 1 family:

temporal lobe epilepsy Epilepsy, Familial Temporal Lobe, 5
Epilepsy, Familial Temporal Lobe, 4 Epilepsy, Familial Temporal Lobe, 2

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1epilepsy syndrome30.9TSPO, PVALB, CASP2, LGI1, SLC12A5, RELN
2encephalitis30.7TSPO, LGI1, PDYN
3mood disorder30.5PDYN, HTR1A, GABBR1, RELN
4focal epilepsy30.5TSPO, LGI1, PDYN
5idiopathic generalized epilepsy30.5LGI1, GABBR1
6schizophrenia30.2PVALB, PDYN, HTR1A, GABBR1, RELN, TSPO
7obsessive-compulsive disorder30.2TSPO, HTR1A, PDYN
8dementia30.2PVALB, HTR1A, APOE, TSPO
9psychotic disorder30.2RELN, HTR1A, PDYN
10neuronitis10.8
11status epilepticus10.7
12frontal lobe epilepsy10.6
13cerebritis10.5
14lateral sclerosis10.4
15autosomal dominant partial epilepsy with auditory features10.4
16epilepsy, familial temporal lobe, 110.4
17parametritis10.4
18visual epilepsy10.4
19chorea-acanthocytosis10.4
20temporal epilepsy, familial10.4
21benign familial mesial temporal lobe epilepsy10.4
22transvestism10.3
23juvenile myoclonic epilepsy10.3
24tetanus10.3
25infantile-onset mesial temporal lobe epilepsy with severe cognitive regression10.3
26mesial temporal lobe epilepsy with hippocampal sclerosis10.3
27transient global amnesia10.1
28capgras syndrome10.1
29choroid plexus papilloma10.1
30major depressive disorder10.1
31dysembryoplastic neuroepithelial tumor10.1
32choroiditis10.1
33cysticercosis10.1
34eclampsia10.1
35alexia10.1
36asperger syndrome10.1
37periventricular nodular heterotopia10.1
38systemic lupus erythematosus10.1
39arachnoiditis10.1
40west syndrome10.1
41ganglioglioma10.1
42myxopapillary ependymoma10.1
43temporal lobe neoplasm10.1
44cerebral malaria10.1
45insulinoma10.1
46acute leukemia10.1
47fetishism10.1
48herpes simplex10.1
49leukemia10.1
50lupus erythematosus10.1

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to temporal lobe epilepsy

Clinical Features for Temporal Lobe Epilepsy

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Drugs & Therapeutics for Temporal Lobe Epilepsy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Temporal Lobe Epilepsy

Drug clinical trials:

Search ClinicalTrials for Temporal Lobe Epilepsy

Search NIH Clinical Center for Temporal Lobe Epilepsy

Search CenterWatch for Temporal Lobe Epilepsy

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Genetic Tests for Temporal Lobe Epilepsy

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Anatomical Context for Temporal Lobe Epilepsy

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32MalaCards
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MalaCards organs/tissues related to Temporal Lobe Epilepsy:

32
Temporal lobe, Brain, Cortex, Bone, Amygdala, Testes, Cerebellum, Heart, Thyroid, Prefrontal cortex, Olfactory bulb, Skin

Animal Models for Temporal Lobe Epilepsy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.2LGI4, PVALB, CALHM1, CASP2, PDYN, HTR1A
2MP:001076811.1GABBR1, SCN1B, APOE, HTR1A, DBP, RELN
3MP:000538610.8PVALB, PDYN, HTR1A, APOE, SCN1B, GABBR1

Publications for Temporal Lobe Epilepsy

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50PubMed
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Articles related to Temporal Lobe Epilepsy:

(show top 50)    (show all 836)
idTitleAuthorsYear
1
The strange sensation of deja vu: not so strange in temporal lobe epilepsy. (23457224)
2013
2
Mesial temporal lobe epilepsy in a patient with spinocerebellar ataxia type 13 (SCA13). (23215817)
2013
3
Pearls & Oy-sters: ictal syncope in a patient with temporal lobe epilepsy. (24166964)
2013
4
Chemotactic and mitogenic stimuli of neuronal apoptosis in patients with medically intractable temporal lobe epilepsy. (22444245)
2013
5
Atypical neuropsychological profiles and cognitive outcome in mesial temporal lobe epilepsy. (23611738)
2013
6
Interleukin-1I^ secretion in hippocampal sclerosis patients with mesial temporal lobe epilepsy. (24147214)
2013
7
Update on temporal lobe epilepsy. (23533737)
2013
8
Periodic epileptiform discharges in mesial temporal lobe epilepsy with hippocampal sclerosis. (23787169)
2013
9
Expressional analysis of the astrocytic Kir4.1 channel in a pilocarpine-induced temporal lobe epilepsy model. (23922547)
2013
10
Spatial recognition memory in a virtual reality task is altered in refractory temporal lobe epilepsy. (23773979)
2013
11
Display of consistent ictal networks in refractory mesial temporal lobe epilepsy. (23639378)
2013
12
18F-flumazenil: a I^-aminobutyric acid A-specific PET radiotracer for the localization of drug-resistant temporal lobe epilepsy. (23857513)
2013
13
Impaired emotional memory recognition after early temporal lobe epilepsy surgery: the fearful face exception? (22901711)
2013
14
Mesial temporal lobe epilepsy with hippocampal sclerosis preceded by eclampsia: a rare association. (24005737)
2013
15
Electrode location and clinical outcome in hippocampal electrical stimulation for mesial temporal lobe epilepsy. (23540624)
2013
16
Elevated serum S-100B levels in children with temporal lobe epilepsy. (23146618)
2013
17
Temporal lobe epilepsy surgery in children versus adults: from etiologies to outcomes. (23908666)
2013
18
Early activation of ventral hippocampus and subiculum during spontaneous seizures in a rat model of temporal lobe epilepsy. (23825415)
2013
19
Pilocarpine-induced status epilepticus and subsequent spontaneous seizures: lack of effect on the number of gonadotropin-releasing hormone-positive neurons in a mouse model of temporal lobe epilepsy. (22209855)
2012
20
Outcomes after temporal lobectomy for temporal lobe epilepsy with hippocampal sclerosis. (23140034)
2012
21
Role of electroencephalography in presurgical evaluation of temporal lobe epilepsy. (23198144)
2012
22
Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. (22396514)
2012
23
Temporal lobe epilepsy in the elderly. (22957236)
2012
24
Failure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis. (22578703)
2012
25
Strategies for antiepileptogenesis: Antiepileptic drugs versus novel approaches evaluated in post-status epilepticus models of temporal lobe epilepsy (22787664)
2012
26
Psychosis in temporal lobe epilepsy: atypical presentation. (22665878)
2012
27
Grey-white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: Inter-observer analysis, histopathological findings, and correlation with clinical variables. (22738717)
2012
28
A Locus Identified on Chromosome18P11.31 is Associated with Hippocampal Abnormalities in a Family with Mesial Temporal Lobe Epilepsy. (23015801)
2012
29
Extrahippocampal desynchronization in nonlesional temporal lobe epilepsy. (22957245)
2012
30
Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury. (23071638)
2012
31
Loss of perivascular Kir4.1 potassium channels in the sclerotic hippocampus of patients with mesial temporal lobe epilepsy. (22878665)
2012
32
Connectivity disruptions in resting-state functional brain networks in children with temporal lobe epilepsy. (22418271)
2012
33
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy. (21635241)
2011
34
Intracranial electroencephalogram to evaluate refractory temporal and frontal lobe epilepsy. (22147314)
2011
35
Temporal lobe pleomorphic xanthoastrocytoma and chronic epilepsy: long-term surgical outcomes. (21741164)
2011
36
Involvement of IRE1I+ signaling in the hippocampus in patients with mesial temporal lobe epilepsy. (20965234)
2011
37
Everyday cognition in temporal lobe and frontal lobe epilepsy. (19713170)
2009
38
Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy. (19437412)
2009
39
Lateral temporal lobe epilepsies: clinical and genetic features. (19469848)
2009
40
Surgery for temporal lobe epilepsy after cerebral malaria. (18515154)
2008
41
Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy. (17437412)
2007
42
Architectural (Type IA) focal cortical dysplasia and parvalbumin immunostaining in temporal lobe epilepsy. (16822257)
2006
43
Medically refractory epilepsy associated with temporal lobe ganglioglioma: characteristics and postoperative outcome. (16318902)
2006
44
Effects of herbimycin A in the pilocarpine model of temporal lobe epilepsy. (16696126)
2006
45
Abnormal phonologic processing in familial lateral temporal lobe epilepsy due to a new LGI1 mutation. (15660777)
2005
46
Alternative splicing of glutamate transporter EAAT2 RNA in neocortex and hippocampus of temporal lobe epilepsy patients. (15246112)
2004
47
Neurotrophin receptor immunoreactivity in the hippocampus of patients with mesial temporal lobe epilepsy. (15541005)
2004
48
Novel locus on chromosome 12q22-q23.3 responsible for familial temporal lobe epilepsy associated with febrile seizures. (15342703)
2004
49
Neocortical abnormalities of [11C]-flumazenil PET in mesial temporal lobe epilepsy. (11294927)
2001
50
Lack of association between an interleukin 1 beta (IL-1beta) gene variation and refractory temporal lobe epilepsy. (11422336)
2001

Genetic Variations for Temporal Lobe Epilepsy

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Expression for genes affiliated with Temporal Lobe Epilepsy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for genes affiliated with Temporal Lobe Epilepsy

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Compounds for genes affiliated with Temporal Lobe Epilepsy

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1glutamate4411.3PVALB, PDYN, APOE, GABBR1, RELN, SLC12A5
2nmda44 2812.2TSPO, GABBR1, APOE, HTR1A, PDYN, PVALB
3gaba4411.2PVALB, PDYN, GABBR1, RELN, SLC12A5, TSPO
4acetylcholine44 49 28 11 2415.2PVALB, PDYN, HTR1A, APOE, GABBR1, TSPO
5dopamine44 28 11 2414.2PVALB, PDYN, HTR1A, APOE, GABBR1, TSPO
6kainate44 2812.2PVALB, PDYN, APOE, GABBR1, TSPO
7potassium44 11 2413.1LGI1, GABBR1, SCN1B, PDYN, CASP2
8morphine44 49 28 1114.1TSPO, GABBR1, PDYN, CASP2
9pentylenetetrazol4411.0TSPO, GABBR1, PDYN
10chloride4411.0TSPO, SLC12A5, GABBR1, PVALB
11bicuculline44 2812.0TSPO, SLC12A5, GABBR1
12naloxone44 49 28 1114.0PDYN, GABBR1, TSPO
13tetrodotoxin44 59 2813.0PVALB, APOE, SCN1B
14opiate4411.0TSPO, GABBR1, PDYN
15ethanol44 49 11 2414.0PVALB, CASP2, PDYN, GABBR1
16abecarnil4411.0HTR1A, TSPO
17levodopa44 1111.9TSPO, HTR1A, PDYN
18carbon-114410.9TSPO, HTR1A
19norepinephrine44 11 2412.9PDYN, HTR1A, GABBR1, TSPO
20dodecylphosphocholine4410.9PDYN, APOE
21benzodiazepines4410.9TSPO, GABBR1
22haloperidol44 28 2 49 1114.9TSPO, HTR1A, PVALB
23buspirone44 28 1112.9HTR1A, TSPO
24damgo44 59 2812.9PDYN, GABBR1
25gamma-hydroxybutyrate4410.8TSPO, GABBR1
26baclofen44 1111.7GABBR1, TSPO
2722r-hydroxycholesterol44 2811.7APOE, TSPO
28dimyristoylphosphatidylcholine4410.7APOE, PDYN
295-hydroxytryptamine4410.7TSPO, GABBR1, HTR1A
30scopolamine44 28 11 2413.6TSPO, HTR1A
31cocaine44 1111.6PDYN, GABBR1, TSPO
32fluvoxamine44 49 1112.3TSPO, HTR1A

GO Terms for genes affiliated with Temporal Lobe Epilepsy

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16Gene Ontology
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Biological processes related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726810.7SLC12A5, GABBR1, SCN1B, PDYN
2peripheral nervous system axon regenerationGO:01401210.6TSPO, APOE
3regulation of behaviorGO:05079510.5RELN, HTR1A
4agingGO:00756810.4CASP2, APOE, TSPO

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle receptor bindingGO:07032610.6RELN, APOE

Products for genes affiliated with Temporal Lobe Epilepsy

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Sources for Temporal Lobe Epilepsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet