MCID: TMP001
MIFTS: 57

Temporal Lobe Epilepsy malady

Summaries for Temporal Lobe Epilepsy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Temporal lobe epilepsy is a chronic neurological condition characterized by recurrent seizures... more...

MalaCards: Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to epilepsy syndrome and encephalitis. An important gene associated with Temporal Lobe Epilepsy is CASP2 (caspase 2, apoptosis-related cysteine peptidase). The drugs mephenytoin and phenytoin and the compounds glutamate and nmda have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and cortex, and related mouse phenotypes are nervous system and mortality/aging.

Aliases & Classifications for Temporal Lobe Epilepsy

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8Disease Ontology, 30LifeMap Discovery™, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

temporal lobe epilepsy 8 30
epilepsy, temporal lobe 8 60
epilepsy temporal lobe 44


External Ids:

Disease Ontology8 DOID:3328
MeSH34 D004833

Related Diseases for Temporal Lobe Epilepsy

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Epilepsy, Familial Temporal Lobe, 1 family:

temporal lobe epilepsy Epilepsy, Familial Temporal Lobe, 5
Epilepsy, Familial Temporal Lobe, 4 Epilepsy, Familial Temporal Lobe, 2

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1epilepsy syndrome30.9TSPO, PVALB, CASP2, LGI1, SLC12A5, RELN
2encephalitis30.7TSPO, LGI1, PDYN
3mood disorder30.5PDYN, HTR1A, GABBR1, RELN
4focal epilepsy30.5TSPO, LGI1, PDYN
5idiopathic generalized epilepsy30.5LGI1, GABBR1
6schizophrenia30.2PVALB, PDYN, HTR1A, GABBR1, RELN, TSPO
7obsessive-compulsive disorder30.2TSPO, HTR1A, PDYN
8dementia30.2PVALB, HTR1A, APOE, TSPO
9psychotic disorder30.2RELN, HTR1A, PDYN
10neuronitis10.8
11status epilepticus10.7
12frontal lobe epilepsy10.6
13cerebritis10.5
14lateral sclerosis10.4
15autosomal dominant partial epilepsy with auditory features10.4
16epilepsy, familial temporal lobe, 110.4
17parametritis10.4
18visual epilepsy10.4
19chorea-acanthocytosis10.4
20temporal epilepsy, familial10.4
21benign familial mesial temporal lobe epilepsy10.4
22transvestism10.3
23juvenile myoclonic epilepsy10.3
24tetanus10.3
25infantile-onset mesial temporal lobe epilepsy with severe cognitive regression10.3
26mesial temporal lobe epilepsy with hippocampal sclerosis10.3
27transient global amnesia10.1
28capgras syndrome10.1
29choroid plexus papilloma10.1
30major depressive disorder10.1
31dysembryoplastic neuroepithelial tumor10.1
32choroiditis10.1
33cysticercosis10.1
34eclampsia10.1
35alexia10.1
36asperger syndrome10.1
37periventricular nodular heterotopia10.1
38systemic lupus erythematosus10.1
39arachnoiditis10.1
40west syndrome10.1
41ganglioglioma10.1
42myxopapillary ependymoma10.1
43temporal lobe neoplasm10.1
44cerebral malaria10.1
45insulinoma10.1
46acute leukemia10.1
47fetishism10.1
48herpes simplex10.1
49leukemia10.1
50lupus erythematosus10.1

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to temporal lobe epilepsy

Clinical Features for Temporal Lobe Epilepsy

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Drugs & Therapeutics for Temporal Lobe Epilepsy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Temporal Lobe Epilepsy

Drug clinical trials:

Search ClinicalTrials for Temporal Lobe Epilepsy

Search NIH Clinical Center for Temporal Lobe Epilepsy

Search CenterWatch for Temporal Lobe Epilepsy

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Genetic Tests for Temporal Lobe Epilepsy

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Anatomical Context for Temporal Lobe Epilepsy

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32MalaCards
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MalaCards organs/tissues related to Temporal Lobe Epilepsy:

32
Temporal lobe, Brain, Cortex, Bone, Amygdala, Testes, Cerebellum, Heart, Thyroid, Prefrontal cortex, Olfactory bulb, Skin

Animal Models for Temporal Lobe Epilepsy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.2LGI4, PVALB, CALHM1, CASP2, PDYN, HTR1A
2MP:001076811.1GABBR1, SCN1B, APOE, HTR1A, DBP, RELN
3MP:000538610.8PVALB, PDYN, HTR1A, APOE, SCN1B, GABBR1

Publications for Temporal Lobe Epilepsy

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50PubMed
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Articles related to Temporal Lobe Epilepsy:

(show top 50)    (show all 836)
idTitleAuthorsYear
1
Seizure outcome after hippocampal deep brain stimulation in a prospective cohort of patients with refractory temporal lobe epilepsy. (23992890)
2014
2
Application of dynamic susceptibility contrast-enhanced perfusion in temporal lobe epilepsy. (23117196)
2013
3
Microtubule-associated proteins in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with granular cell layer dispersion. (24069608)
2013
4
Epileptic nystagmus and vertigo associated with bilateral temporal and frontal lobe epilepsy. (24353868)
2013
5
Mislocalization of AQP4 precedes chronic seizures in the kainate model of temporal lobe epilepsy. (23357720)
2013
6
Predicting and preventing psychopathology following temporal lobe epilepsy surgery. (23246146)
2013
7
Investigating higher-order cognitive functions in temporal lobe epilepsy: cognitive estimation. (24012509)
2013
8
Famous face identification in temporal lobe epilepsy: support for a multimodal integration model of semantic memory. (23040175)
2013
9
Slowly evolving trends in temporal lobe epilepsy management at london health sciences centre. (23533736)
2013
10
Selective amygdalohippocampectomy versus standard temporal lobectomy in patients with mesial temporal lobe epilepsy and unilateral hippocampal sclerosis. (23022178)
2013
11
Rhythmic ictal nonclonic hand (RINCH) motions in temporal lobe epilepsy: invasive EEG findings, incidence, and lateralizing value. (23928193)
2013
12
Disrupted segregation of working memory networks in temporal lobe epilepsy. (24179782)
2013
13
The cortical excitability profile of temporal lobe epilepsy. (24112043)
2013
14
Pharmacological blockade of IL-1I^/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy. (23938763)
2013
15
Self-reported quality of life in pharmacoresistant temporal lobe epilepsy: correlation with clinical variables and memory evaluation. (23906668)
2013
16
Seizure outcome in surgically treated drug-resistant mesial temporal lobe epilepsy based on the recent histopathological classifications. (23641822)
2013
17
Amygdala enlargement occurs in patients with mesial temporal lobe epilepsy and hippocampal sclerosis with early epilepsy onset. (24074891)
2013
18
Changes in interictal spike features precede the onset of temporal lobe epilepsy. (22718546)
2012
19
Mesial temporal sclerosis is linked with more widespread white matter changes in temporal lobe epilepsy. (24179742)
2012
20
Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis. (22615744)
2012
21
Temporal lobe epilepsy after refractory status epilepticus: an illustrative case and review of the literature. (22953058)
2012
22
Genetics of temporal lobe epilepsy: a review. (22957248)
2012
23
Sexual desire and satisfaction after resective surgery in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. (23103313)
2012
24
Hyperfamiliarity in patients with temporal lobe epilepsy. (22579121)
2012
25
Language mapping in temporal lobe epilepsy in children: special considerations. (22957246)
2012
26
The role of voxel-based morphometry in the detection of cortical dysplasia within the temporal pole in patients with intractable mesial temporal lobe epilepsy. (22510082)
2012
27
Microsurgical anatomy of the temporal lobe and its implications on temporal lobe epilepsy surgery. (22957242)
2012
28
Different structural correlates for verbal memory impairment in temporal lobe epilepsy with and without mesial temporal lobe sclerosis. (21438080)
2012
29
The "natural" history of medically treated temporal lobe epilepsy: what can an evidence-based approach tell us? (22953059)
2012
30
Increased PLA2 activity in the hippocampus of patients with temporal lobe epilepsy and psychosis. (21813137)
2011
31
Serotonin transporter gene (5HTT) polymorphisms and temporal lobe epilepsy. (21498047)
2011
32
Kallikrein 1 is overexpressed by astrocytes in the hippocampus of patients with refractory temporal lobe epilepsy, associated with hippocampal sclerosis. (21211543)
2011
33
Abnormal expression of netrin-G2 in temporal lobe epilepsy neurons in humans and a rat model. (20382146)
2010
34
Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: the first report from Asian families. (19780791)
2010
35
Modulation of androgen and estrogen receptor expression by antiepileptic drugs and steroids in hippocampus of patients with temporal lobe epilepsy. (19490052)
2009
36
Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. (17446080)
2007
37
Structural anomaly of left lateral temporal lobe in epilepsy due to mutated LGI1. (17875918)
2007
38
Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis. (17088374)
2007
39
Upregulated expression of postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA in temporal lobe tissue of epilepsy. (17506987)
2007
40
Endoplasmic reticulum stress and apoptosis signaling in human temporal lobe epilepsy. (16651883)
2006
41
Decreased expression of thyroid receptor-associated protein 220 in temporal lobe tissue of patients with refractory epilepsy. (16934225)
2006
42
Asymmetry of long-latency auditory evoked potentials in LGI1-related autosomal dominant lateral temporal lobe epilepsy. (16190946)
2005
43
Transient downregulation of Sema3A mRNA in a rat model for temporal lobe epilepsy. A novel molecular event potentially contributing to mossy fiber sprouting. (12821384)
2003
44
GABABR1 receptor protein expression in human mesial temporal cortex: changes in temporal lobe epilepsy. (12115687)
2002
45
Chromogranins in temporal lobe epilepsy. (10999531)
2000
46
Early loss of interneurons and delayed subunit-specific changes in GABA(A)-receptor expression in a mouse model of mesial temporal lobe epilepsy. (10902900)
2000
47
Cisternal S100 protein and neuron-specific enolase are elevated and site-specific markers in intractable temporal lobe epilepsy. (10463853)
1999
48
Serum sex hormones are altered in patients with chronic temporal lobe epilepsy receiving anticonvulsant medication. (9821980)
1998
49
Neuropeptide Y expression in animal models of temporal lobe epilepsy. (9302518)
1996
50
The temporal lobe epilepsy syndrome elucidated through SA,ren Kierkegaard's authorship and life. (3293355)
1988

Genetic Variations for Temporal Lobe Epilepsy

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Expression for genes affiliated with Temporal Lobe Epilepsy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for genes affiliated with Temporal Lobe Epilepsy

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Compounds for genes affiliated with Temporal Lobe Epilepsy

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1glutamate4411.3PVALB, PDYN, APOE, GABBR1, RELN, SLC12A5
2nmda44 2812.2TSPO, GABBR1, APOE, HTR1A, PDYN, PVALB
3gaba4411.2PVALB, PDYN, GABBR1, RELN, SLC12A5, TSPO
4acetylcholine44 49 28 11 2415.2PVALB, PDYN, HTR1A, APOE, GABBR1, TSPO
5dopamine44 28 11 2414.2PVALB, PDYN, HTR1A, APOE, GABBR1, TSPO
6kainate44 2812.2PVALB, PDYN, APOE, GABBR1, TSPO
7potassium44 11 2413.1LGI1, GABBR1, SCN1B, PDYN, CASP2
8morphine44 49 28 1114.1TSPO, GABBR1, PDYN, CASP2
9pentylenetetrazol4411.0TSPO, GABBR1, PDYN
10chloride4411.0TSPO, SLC12A5, GABBR1, PVALB
11bicuculline44 2812.0TSPO, SLC12A5, GABBR1
12naloxone44 49 28 1114.0PDYN, GABBR1, TSPO
13tetrodotoxin44 59 2813.0PVALB, APOE, SCN1B
14opiate4411.0TSPO, GABBR1, PDYN
15ethanol44 49 11 2414.0PVALB, CASP2, PDYN, GABBR1
16abecarnil4411.0HTR1A, TSPO
17levodopa44 1111.9TSPO, HTR1A, PDYN
18carbon-114410.9TSPO, HTR1A
19norepinephrine44 11 2412.9PDYN, HTR1A, GABBR1, TSPO
20dodecylphosphocholine4410.9PDYN, APOE
21benzodiazepines4410.9TSPO, GABBR1
22haloperidol44 28 2 49 1114.9TSPO, HTR1A, PVALB
23buspirone44 28 1112.9HTR1A, TSPO
24damgo44 59 2812.9PDYN, GABBR1
25gamma-hydroxybutyrate4410.8TSPO, GABBR1
26baclofen44 1111.7GABBR1, TSPO
2722r-hydroxycholesterol44 2811.7APOE, TSPO
28dimyristoylphosphatidylcholine4410.7APOE, PDYN
295-hydroxytryptamine4410.7TSPO, GABBR1, HTR1A
30scopolamine44 28 11 2413.6TSPO, HTR1A
31cocaine44 1111.6PDYN, GABBR1, TSPO
32fluvoxamine44 49 1112.3TSPO, HTR1A

GO Terms for genes affiliated with Temporal Lobe Epilepsy

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16Gene Ontology
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Biological processes related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726810.7SLC12A5, GABBR1, SCN1B, PDYN
2peripheral nervous system axon regenerationGO:01401210.6TSPO, APOE
3regulation of behaviorGO:05079510.5RELN, HTR1A
4agingGO:00756810.4CASP2, APOE, TSPO

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle receptor bindingGO:07032610.6RELN, APOE

Products for genes affiliated with Temporal Lobe Epilepsy

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Sources for Temporal Lobe Epilepsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet