Aliases & Classifications for Temporal Lobe Epilepsy

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Temporal Lobe Epilepsy, Aliases & Descriptions:

Name: Temporal Lobe Epilepsy 30 9
Epilepsy, Temporal Lobe 9 60
 
Epilepsy Temporal Lobe 43


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Disease Ontology9 DOID:3328
MeSH33 D004833

Summaries for Temporal Lobe Epilepsy

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Wikipedia:63 Temporal lobe epilepsy is a chronic neurological condition characterized by recurrent, unprovoked... more...

MalaCards based summary: Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to febrile seizures and encephalitis. An important gene associated with Temporal Lobe Epilepsy is CASP2 (caspase 2, apoptosis-related cysteine peptidase), and among its related pathways are Interaction between L1 and Ankyrins and Neuroscience. The drugs mephenytoin and phenytoin and the compounds dodecylphosphocholine and dimyristoylphosphatidylcholine have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and cortex, and related mouse phenotypes are adipose tissue and mortality/aging.

Related Diseases for Temporal Lobe Epilepsy

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Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1febrile seizures31.2SCN1A, LGI1, SCN1B
2encephalitis31.1PDYN, TSPO, LGI1
3frontal lobe epilepsy31.1SCN1B, SCN1A
4mood disorder30.5RELN, HTR1A, GABBR1, PDYN
5psychotic disorder30.5RELN, HTR1A, PDYN
6obsessive-compulsive disorder30.4PDYN, TSPO, HTR1A
7dementia30.4HTR1A, APOE, TSPO
8schizophrenia30.0GABBR1, TSPO, PDYN, HTR1A, RELN
9epilepsy syndrome29.2GABBR1, SCN1A, HTR1A, PDYN, CASP2, LGI1
10mesial temporal lobe epilepsy with hippocampal sclerosis11.0
11neuronitis10.9
12status epilepticus10.7
13cerebritis10.6
14autosomal dominant partial epilepsy with auditory features10.5
15limbic encephalitis10.5
16scn1a-related seizure disorders10.5SCN1A
17encephalocele10.5
18syncope10.5
19hepatic coma10.4TSPO
20epilepsy, familial temporal lobe, 110.4
21familial mesial temporal lobe epilepsy with febrile seizures10.4
22benign familial mesial temporal lobe epilepsy10.4
23infantile-onset mesial temporal lobe epilepsy with severe cognitive regression10.4
24major depressive disorder and accelerated response to antidepressant drug treatment10.4HTR1A
25epilepsy, familial temporal lobe, 210.3
26parametritis10.3
27transvestism10.3
28tetanus10.3
29autonomic dysfunction10.3
30seizure disorder10.3
31epilepsy, generalized, with febrile seizures plus, type 510.3SCN1A, GABBR1
32withdrawal disorder10.3GABBR1, PDYN
33drug addiction10.3GABBR1, PDYN
34creutzfeldt-jakob disease10.3TSPO, APOE
35dementia, frontotemporal10.2RELN, APOE
36vascular dementia10.2HTR1A, APOE
37cerebrovascular disease10.2TSPO, APOE
38systemic lupus erythematosus10.2
39mitochondrial complex i deficiency10.2
40malaria10.2
41urbach-wiethe disease10.2
42choroid plexus papilloma10.2
43west syndrome10.2
44insulinoma10.2
45leukemia10.2
46dysembryoplastic neuroepithelial tumor10.2
47capgras syndrome10.2
48myxopapillary ependymoma10.2
49ganglioglioma10.2
50choroiditis10.2

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to temporal lobe epilepsy

Symptoms for Temporal Lobe Epilepsy

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Drugs & Therapeutics for Temporal Lobe Epilepsy

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Drug clinical trials:

Search ClinicalTrials for Temporal Lobe Epilepsy

Search NIH Clinical Center for Temporal Lobe Epilepsy

Inferred drug relations via UMLS60/NDF-RT39:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Genetic Tests for Temporal Lobe Epilepsy

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Anatomical Context for Temporal Lobe Epilepsy

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MalaCards organs/tissues related to Temporal Lobe Epilepsy:

31
Temporal lobe, Brain, Cortex, Bone, Amygdala, Testes, Cerebellum, Heart, Skin, Prefrontal cortex, Olfactory bulb

Animal Models for Temporal Lobe Epilepsy or affiliated genes

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MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7APOE, LGI1, ACOT7, PDYN, GABBR1
2MP:00107687.8SCN1B, APOE, RELN, LGI1, HTR1A, CASP2
3MP:00053787.3SCN1A, SCN1B, APOE, RELN, LGI1, ACOT7
4MP:00053867.2SCN1A, SCN1B, APOE, RELN, LGI1, HTR1A
5MP:00036316.6GABBR1, SCN1A, SCN1B, APOE, RELN, LGI1

Publications for Temporal Lobe Epilepsy

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Articles related to Temporal Lobe Epilepsy:

(show top 50)    (show all 842)
idTitleAuthorsYear
1
Circadian rhythm and profile in patients with juvenile myoclonic epilepsy and temporal lobe epilepsy. (25608119)
2015
2
Dissociated multimodal hubs and seizures in temporal lobe epilepsy. (25909080)
2015
3
Ictal and postictal semiology in patients with bilateral temporal lobe epilepsy. (25282104)
2014
4
Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy. (23398413)
2013
5
Defining "epileptogenesis" and identifying "antiepileptogenic targets" in animal models of acquired temporal lobe epilepsy is not as simple as it might seem. (22342985)
2013
6
Impaired and facilitated functional networks in temporal lobe epilepsy. (24073391)
2013
7
P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study. (23786896)
2013
8
Characteristics of temporal lobe epilepsy with no ictal impairment of consciousness. (23369403)
2013
9
Functional connectivity estimated from intracranial EEG predicts surgical outcome in intractable temporal lobe epilepsy. (24205027)
2013
10
The strange sensation of deja vu: not so strange in temporal lobe epilepsy. (23457224)
2013
11
Application of dynamic susceptibility contrast-enhanced perfusion in temporal lobe epilepsy. (23117196)
2013
12
Subtle temporal lobe epilepsy with headache as the major complaint: what can we learn from the long-delayed diagnosis? (23290451)
2013
13
Resting state networks in temporal lobe epilepsy. (24117098)
2013
14
Sleep modulation of epileptic activity in mesial and neocortical temporal lobe epilepsy: a study with depth and subdural electrodes. (23751358)
2013
15
Pearls & Oy-sters: ictal syncope in a patient with temporal lobe epilepsy. (24325018)
2013
16
Enhanced sequential reaction time task performance in a rat model of mesial temporal lobe epilepsy with classic hippocampal sclerosis. (23511251)
2013
17
Mesial temporal lobe epilepsy in a patient with spinocerebellar ataxia type 13 (SCA13). (23215817)
2013
18
Outcomes for temporal lobe epilepsy operations may not be equal: a call for an RCT of ATL vs SAH. (23553476)
2013
19
Whole mitochondrial DNA variations in hippocampal surgical specimens and blood samples with high-throughput sequencing: a case of mesial temporal lobe epilepsy with hippocampal sclerosis. (23872536)
2013
20
Increased metallothionein I/II expression in patients with temporal lobe epilepsy. (23028585)
2012
21
Critically appraised topic. Temporal lobe epilepsy and hippocampal stimulation. (23041406)
2012
22
Pathophysiology of mood disorders in temporal lobe epilepsy. (23429849)
2012
23
Changes in interictal spike features precede the onset of temporal lobe epilepsy. (22718546)
2012
24
Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy. (22238156)
2012
25
Temporal Lobe Epilepsy and the BDNF Receptor, TrkB (22787630)
2012
26
Medial temporal lobe epilepsy is associated with neuronal fibre loss and paradoxical increase in structural connectivity of limbic structures. (22764263)
2012
27
Serious adverse effects of gamma knife radiosurgery for mesial temporal lobe epilepsy. (23269044)
2012
28
Mesial temporal sclerosis is linked with more widespread white matter changes in temporal lobe epilepsy. (24179742)
2012
29
Aberrant glutamate receptor 5 expression in temporal lobe epilepsy lesions. (19941835)
2010
30
Functional variant in complement C3 gene promoter and genetic susceptibility to temporal lobe epilepsy and febrile seizures. (20862287)
2010
31
Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. (19864112)
2010
32
Changes in the expression of selenoproteins in mesial temporal lobe epilepsy patients. (19499324)
2009
33
Spatiotemporospectral characteristics of scalp ictal EEG in mesial temporal lobe epilepsy with hippocampal sclerosis. (19563787)
2009
34
Surgery for temporal lobe epilepsy after cerebral malaria. (18515154)
2008
35
A Kv4.2 truncation mutation in a patient with temporal lobe epilepsy. (16934482)
2006
36
Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy. (16121124)
2006
37
Lack of GABABR1 gene variation (G1465A) in a Chinese population with temporal lobe epilepsy. (16278087)
2005
38
Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy. (15694259)
2005
39
Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. (15057313)
2004
40
Perivascular clustering in temporal lobe epilepsy: oligodendroglial cells of unknown function. (15480711)
2004
41
Reduction of hippocampal collapsin response mediated protein-2 in patients with mesial temporal lobe epilepsy. (15672539)
2004
42
Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. (12122039)
2002
43
Chronic encephalitis and temporal lobe epilepsy: a variant of Rasmussen's syndrome? (11245727)
2001
44
Inter-ictal and post-ictal psychoses in frontal lobe epilepsy: a retrospective comparison with psychoses in temporal lobe epilepsy. (10933987)
2000
45
Ultrastructural localization of dynorphin in the dentate gyrus in human temporal lobe epilepsy: a study of reorganized mossy fiber synapses. (10098940)
1999
46
Disturbance of visual information processing in temporal lobe epilepsy: in comparison with idiopathic generalized epilepsy. (8271589)
1993
47
MRI in the presurgical evaluation of patients with frontal lobe epilepsy and children with temporal lobe epilepsy: pathologic correlation and prognostic importance. (1563338)
1992
48
Developmental anterobasal temporal encephalocele and temporal lobe epilepsy. (2033453)
1991
49
Schizophrenia-like psychosis with Capgras syndrome in a patient with right temporal lobe epilepsy--a case report. (4095563)
1985
50
Transient global amnesia: manifestation of medial temporal lobe epilepsy. (455733)
1979

Variations for Temporal Lobe Epilepsy

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Expression for genes affiliated with Temporal Lobe Epilepsy

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Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for genes affiliated with Temporal Lobe Epilepsy

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Compounds for genes affiliated with Temporal Lobe Epilepsy

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Compounds related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1dodecylphosphocholine4310.3PDYN, APOE
2dimyristoylphosphatidylcholine4310.2PDYN, APOE
3damgo43 28 5912.2PDYN, GABBR1
4benzodiazepines4310.2TSPO, GABBR1
522r-hydroxycholesterol43 2811.2APOE, TSPO
6gamma-hydroxybutyrate4310.1TSPO, GABBR1
7baclofen43 1211.1TSPO, GABBR1
8nitrazepam43 1211.1SCN1A, TSPO
9bicuculline43 2811.1TSPO, GABBR1
10abecarnil4310.1HTR1A, TSPO
11carbon-114310.1HTR1A, TSPO
12benzodiazepine4310.0TSPO, GABBR1
13buspirone43 28 1212.0TSPO, HTR1A
14dopac4310.0SCG2, GABBR1
15clonazepam43 1211.0TSPO, GABBR1
16qx 314 chloride5910.0SCN1A, SCN1B
17tetrodotoxin citrate5910.0SCN1A, SCN1B
18phrixotoxin 35910.0SCN1A, SCN1B
19thiamine43 2 24 1213.0APOE, TSPO
20muscimol43 59 2812.0GABBR1, TSPO
21veratridine43 59 2812.0SCN1A, SCN1B
22scopolamine43 28 24 1212.9TSPO, HTR1A
23picrotoxin43 28 1211.9TSPO, GABBR1
24fluvoxamine43 49 1211.9TSPO, HTR1A
25pentylenetetrazol439.9TSPO, PDYN, GABBR1
26clomipramine43 49 1211.9HTR1A, TSPO
27naloxone43 28 49 1212.9TSPO, PDYN, GABBR1
28opiate439.9GABBR1, PDYN, TSPO
29cocaine43 1210.8GABBR1, PDYN, TSPO
30nicotine43 28 49 1212.8APOE, TSPO, PDYN
31tetrodotoxin43 59 2811.8SCN1A, SCN1B, APOE
32spec-t439.7TSPO, APOE
33l-tryptophan49 28 43 24 1213.7TSPO, HTR1A
34levodopa43 1210.7TSPO, HTR1A, PDYN
35amitriptyline43 28 49 1212.7GABBR1, HTR1A
36glutamine439.6APOE, TSPO, CASP2, PDYN
37morphine43 49 28 1212.6TSPO, CASP2, PDYN, GABBR1
38kainate43 2810.6APOE, TSPO, PDYN, GABBR1
39gaba439.6GABBR1, PDYN, RELN, TSPO
40glutamate439.3GABBR1, PDYN, RELN, TSPO, APOE
41gnrh439.3SCG2, PDYN, GABBR1
42zonisamide43 49 1211.3SCN1B, SCN1A
435-hydroxytryptamine439.2GABBR1, HTR1A, TSPO, SCG2
44cysteine439.1SCG2, APOE, CASP2, PDYN, GABBR1
45adenylate439.1GABBR1, PDYN, HTR1A, SCG2
46nmda43 289.9GABBR1, PDYN, HTR1A, RELN, TSPO, APOE
47norepinephrine43 24 1210.9GABBR1, PDYN, HTR1A, TSPO, SCG2
48potassium43 24 1210.9SCN1A, SCN1B, LGI1, CASP2, PDYN, GABBR1
49acetylcholine43 49 28 24 1212.7SCG2, APOE, TSPO, HTR1A, PDYN, GABBR1
50dopamine43 28 24 1211.6GABBR1, PDYN, HTR1A, TSPO, APOE, SCG2

GO Terms for genes affiliated with Temporal Lobe Epilepsy

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Cellular components related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:00015189.7SCN1B, SCN1A
2node of RanvierGO:00332689.7SCN1B, SCN1A
3intercalated discGO:00147049.6SCN1B, SCN1A
4T-tubuleGO:00303159.5SCN1B, SCN1A
5dendriteGO:00304259.4APOE, RELN, GABBR1
6extracellular regionGO:00055768.7GABBR1, PDYN, LGI1, APOE, SCN1B

Biological processes related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system axon regenerationGO:001401210.0TSPO, APOE
2regulation of behaviorGO:00507959.8HTR1A, RELN
3negative regulation of endothelial cell proliferationGO:00019379.7APOE, SCG2
4neuronal action potential propagationGO:00192279.7SCN1B, SCN1A
5agingGO:00075689.5APOE, TSPO, CASP2
6synaptic transmissionGO:00072688.5GABBR1, PDYN, TSPO, SCN1B

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle receptor bindingGO:00703269.7RELN, APOE
2voltage-gated sodium channel activityGO:00052489.6SCN1B, SCN1A

Products for genes affiliated with Temporal Lobe Epilepsy

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Sources for Temporal Lobe Epilepsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet