MCID: TMP001
MIFTS: 57

Temporal Lobe Epilepsy malady

Summaries for Temporal Lobe Epilepsy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Temporal lobe epilepsy is a chronic neurological condition characterized by recurrent seizures... more...

MalaCards: Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to epilepsy syndrome and encephalitis. An important gene associated with Temporal Lobe Epilepsy is CASP2 (caspase 2, apoptosis-related cysteine peptidase). The drugs phenytoin and phenytoin sodium and the compounds glutamate and nmda have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and cortex, and related mouse phenotypes are nervous system and mortality/aging.

Aliases & Classifications for Temporal Lobe Epilepsy

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8Disease Ontology, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

temporal lobe epilepsy 8 30
epilepsy, temporal lobe 8 60
epilepsy temporal lobe 44


External Ids:

Disease Ontology8 DOID:3328
MeSH34 D004833

Related Diseases for Temporal Lobe Epilepsy

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Epilepsy, Familial Temporal Lobe, 1 family:

temporal lobe epilepsy Epilepsy, Familial Temporal Lobe, 5
Epilepsy, Familial Temporal Lobe, 4 Epilepsy, Familial Temporal Lobe, 2

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1epilepsy syndrome30.9TSPO, PVALB, CASP2, LGI1, SLC12A5, RELN
2encephalitis30.7TSPO, LGI1, PDYN
3mood disorder30.5PDYN, HTR1A, GABBR1, RELN
4focal epilepsy30.5TSPO, LGI1, PDYN
5idiopathic generalized epilepsy30.5LGI1, GABBR1
6schizophrenia30.2PVALB, PDYN, HTR1A, GABBR1, RELN, TSPO
7obsessive-compulsive disorder30.2TSPO, HTR1A, PDYN
8dementia30.2PVALB, HTR1A, APOE, TSPO
9psychotic disorder30.2RELN, HTR1A, PDYN
10neuronitis10.8
11status epilepticus10.7
12frontal lobe epilepsy10.6
13cerebritis10.5
14lateral sclerosis10.4
15autosomal dominant partial epilepsy with auditory features10.4
16epilepsy, familial temporal lobe, 110.4
17parametritis10.4
18visual epilepsy10.4
19chorea-acanthocytosis10.4
20temporal epilepsy, familial10.4
21benign familial mesial temporal lobe epilepsy10.4
22transvestism10.3
23juvenile myoclonic epilepsy10.3
24tetanus10.3
25infantile-onset mesial temporal lobe epilepsy with severe cognitive regression10.3
26mesial temporal lobe epilepsy with hippocampal sclerosis10.3
27transient global amnesia10.1
28capgras syndrome10.1
29choroid plexus papilloma10.1
30major depressive disorder10.1
31dysembryoplastic neuroepithelial tumor10.1
32choroiditis10.1
33cysticercosis10.1
34eclampsia10.1
35alexia10.1
36asperger syndrome10.1
37periventricular nodular heterotopia10.1
38systemic lupus erythematosus10.1
39arachnoiditis10.1
40west syndrome10.1
41ganglioglioma10.1
42myxopapillary ependymoma10.1
43temporal lobe neoplasm10.1
44cerebral malaria10.1
45insulinoma10.1
46acute leukemia10.1
47fetishism10.1
48herpes simplex10.1
49leukemia10.1
50lupus erythematosus10.1

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to temporal lobe epilepsy

Clinical Features for Temporal Lobe Epilepsy

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Drugs & Therapeutics for Temporal Lobe Epilepsy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Temporal Lobe Epilepsy

Drug clinical trials:

Search ClinicalTrials for Temporal Lobe Epilepsy

Search NIH Clinical Center for Temporal Lobe Epilepsy

Search CenterWatch for Temporal Lobe Epilepsy

Inferred drug relations via UMLS60/NDF-RT40:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Genetic Tests for Temporal Lobe Epilepsy

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Anatomical Context for Temporal Lobe Epilepsy

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32MalaCards
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MalaCards organs/tissues related to Temporal Lobe Epilepsy:

32
Temporal lobe, Brain, Cortex, Bone, Amygdala, Testes, Cerebellum, Heart, Prefrontal cortex, Thyroid, Skin, Olfactory bulb

Animal Models for Temporal Lobe Epilepsy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.2LGI4, PVALB, CALHM1, CASP2, PDYN, HTR1A
2MP:001076811.1GABBR1, SCN1B, APOE, HTR1A, DBP, RELN
3MP:000538610.8PVALB, PDYN, HTR1A, APOE, SCN1B, GABBR1

Publications for Temporal Lobe Epilepsy

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50PubMed
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Articles related to Temporal Lobe Epilepsy:

(show top 50)    (show all 836)
idTitleAuthorsYear
1
Failures in temporal lobe epilepsy surgery. (24141482)
2014
2
Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy. (23398413)
2013
3
Characteristics of temporal lobe epilepsy with no ictal impairment of consciousness. (23369403)
2013
4
Sleep modulation of epileptic activity in mesial and neocortical temporal lobe epilepsy: a study with depth and subdural electrodes. (23751358)
2013
5
Assessing hippocampal functional reserve in temporal lobe epilepsy: a multi-voxel pattern analysis of fMRI data. (23352740)
2013
6
Expressions of tumor necrosis factor alpha and microRNA-155 in immature rat model of status epilepticus and children with mesial temporal lobe epilepsy. (23636891)
2013
7
Transient impact of spike on theta rhythm in temporal lobe epilepsy. (24100023)
2013
8
Autobiographical memory in children with temporal lobe epilepsy. (24050601)
2013
9
Patient satisfaction with temporal lobectomy/selective amygdalohippocampectomy for temporal lobe epilepsy and its relationship with Engel classification and the side of lobectomy. (24210461)
2013
10
Mitochondrial involvement and oxidative stress in temporal lobe epilepsy. (23411150)
2013
11
Expression of Growth-associated Protein 43 in the Hippocampus of Mesial Temporal Lobe Epilepsy Mouse Model. (24382233)
2013
12
Intellectual functioning in children with epilepsy: frontal lobe epilepsy, childhood absence epilepsy and benign epilepsy with centro-temporal spikes. (23992789)
2013
13
Post-operative mismatch negativity recovery in a temporal lobe epilepsy patient with cavernous angioma. (22817994)
2013
14
The effects of temporal lobe epilepsy on scene encoding. (23207513)
2013
15
Disrupted causal connectivity in mesial temporal lobe epilepsy. (23696798)
2013
16
Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice. (23611869)
2013
17
State-dependent precursors of seizures in correlation-based functional networks of electrocorticograms of patients with temporal lobe epilepsy. (22271261)
2012
18
Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy. (22832858)
2012
19
Late-onset temporal lobe epilepsy in a patient with juvenile myoclonic epilepsy. (22580373)
2012
20
Spatial patterns of water diffusion along white matter tracts in temporal lobe epilepsy. (22815555)
2012
21
Determining surgical candidacy in temporal lobe epilepsy. (22957238)
2012
22
Altered neurotransmitter release, vesicle recycling and presynaptic structure in the pilocarpine model of temporal lobe epilepsy. (22344585)
2012
23
Long-term radiosurgery effects in the treatment of temporal lobe epilepsy. (22839651)
2012
24
A review of the epidemiology of temporal lobe epilepsy. (22957234)
2012
25
Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy. (22874854)
2012
26
Cerebral vasospasm following temporal lobe epilepsy surgery. (22442433)
2012
27
Predictive model for refractoriness in temporal lobe epilepsy based on clinical and diagnostic test data. (22472321)
2012
28
Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response. (22535415)
2012
29
Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy. (22201552)
2012
30
Neuropsychology in temporal lobe epilepsy: influences from cognitive neuroscience and functional neuroimaging. (22957249)
2012
31
The immunosuppressant cyclosporin A inhibits recurrent seizures in an experimental model of temporal lobe epilepsy. (22981977)
2012
32
PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy. (23136853)
2012
33
A polymorphism in CALHM1 is associated with temporal lobe epilepsy. (21439911)
2011
34
Somatosensory rub evoked reflex epilepsy of a temporal lobe origin. (20640465)
2011
35
Bilateral temporal lobe epilepsy confirmed with intracranial EEG in chorea-acanthocytosis. (21251854)
2011
36
Focal epilepsy of probable temporal lobe origin in a Gypsy family showing linkage to a novel locus on 7p21.3. (21645995)
2011
37
Altered expression of the small guanosine triphosphatase RhoA in human temporal lobe epilepsy. (20140537)
2010
38
ApoE epsilon4 genotype and the age at onset of temporal lobe epilepsy: a case-control study and meta-analysis. (20554432)
2010
39
Association of serotonin transporter promoter (5-HTTLPR) and intron 2 (VNTR-2) polymorphisms with treatment response in temporal lobe epilepsy. (20655708)
2010
40
ApoE epsilon4 is not associated with posictal confusion in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. (19375284)
2009
41
Clinical characteristics and LGI1 gene mutation analysis on an autosomal dominant lateral temporal lobe epilepsy]. (19537038)
2009
42
Preoperative depressive symptoms predict postoperative seizure outcome in temporal and frontal lobe epilepsy. (19879810)
2009
43
Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. (19701204)
2009
44
Analysis of LGI1 promoter sequence, PDYN and GABBR1 polymorphisms in sporadic and familial lateral temporal lobe epilepsy. (18355961)
2008
45
Usefulness of [11C]methionine PET in the diagnosis of dysembryoplastic neuroepithelial tumor with temporal lobe epilepsy. (14692906)
2004
46
Glycosaminoglycan levels and proteoglycan expression are altered in the hippocampus of patients with mesial temporal lobe epilepsy. (12242104)
2002
47
Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy. (12399076)
2002
48
Somatostatin- and neuropeptide Y-synthesizing neurones in the fascia dentata of humans with temporal lobe epilepsy. (11287369)
2001
49
Health-related quality of life (HRQOL), activity of daily living (ADL) and depressive mood disorder in temporal lobe epilepsy patients. (10222299)
1999
50
Imaging of delta- and mu-opioid receptors in temporal lobe epilepsy by positron emission tomography. (9066357)
1997

Genetic Variations for Temporal Lobe Epilepsy

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Expression for genes affiliated with Temporal Lobe Epilepsy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for genes affiliated with Temporal Lobe Epilepsy

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Compounds for genes affiliated with Temporal Lobe Epilepsy

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1glutamate4411.3PVALB, PDYN, APOE, GABBR1, RELN, SLC12A5
2nmda44 2812.2TSPO, GABBR1, APOE, HTR1A, PDYN, PVALB
3gaba4411.2PVALB, PDYN, GABBR1, RELN, SLC12A5, TSPO
4acetylcholine44 49 28 11 2415.2PVALB, PDYN, HTR1A, APOE, GABBR1, TSPO
5dopamine44 28 11 2414.2PVALB, PDYN, HTR1A, APOE, GABBR1, TSPO
6kainate44 2812.2PVALB, PDYN, APOE, GABBR1, TSPO
7potassium44 11 2413.1LGI1, GABBR1, SCN1B, PDYN, CASP2
8morphine44 49 28 1114.1TSPO, GABBR1, PDYN, CASP2
9pentylenetetrazol4411.0TSPO, GABBR1, PDYN
10chloride4411.0TSPO, SLC12A5, GABBR1, PVALB
11bicuculline44 2812.0TSPO, SLC12A5, GABBR1
12naloxone44 49 28 1114.0PDYN, GABBR1, TSPO
13tetrodotoxin44 59 2813.0PVALB, APOE, SCN1B
14opiate4411.0TSPO, GABBR1, PDYN
15ethanol44 49 11 2414.0PVALB, CASP2, PDYN, GABBR1
16abecarnil4411.0HTR1A, TSPO
17levodopa44 1111.9TSPO, HTR1A, PDYN
18carbon-114410.9TSPO, HTR1A
19norepinephrine44 11 2412.9PDYN, HTR1A, GABBR1, TSPO
20dodecylphosphocholine4410.9PDYN, APOE
21benzodiazepines4410.9TSPO, GABBR1
22haloperidol44 28 2 49 1114.9TSPO, HTR1A, PVALB
23buspirone44 28 1112.9HTR1A, TSPO
24damgo44 59 2812.9PDYN, GABBR1
25gamma-hydroxybutyrate4410.8TSPO, GABBR1
26baclofen44 1111.7GABBR1, TSPO
2722r-hydroxycholesterol44 2811.7APOE, TSPO
28dimyristoylphosphatidylcholine4410.7APOE, PDYN
295-hydroxytryptamine4410.7TSPO, GABBR1, HTR1A
30scopolamine44 28 11 2413.6TSPO, HTR1A
31cocaine44 1111.6PDYN, GABBR1, TSPO
32fluvoxamine44 49 1112.3TSPO, HTR1A

GO Terms for genes affiliated with Temporal Lobe Epilepsy

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16Gene Ontology
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Biological processes related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726810.7SLC12A5, GABBR1, SCN1B, PDYN
2peripheral nervous system axon regenerationGO:01401210.6TSPO, APOE
3regulation of behaviorGO:05079510.5RELN, HTR1A
4agingGO:00756810.4CASP2, APOE, TSPO

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle receptor bindingGO:07032610.6RELN, APOE

Products for genes affiliated with Temporal Lobe Epilepsy

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Sources for Temporal Lobe Epilepsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet