MCID: TMP001
MIFTS: 50

Temporal Lobe Epilepsy malady

Categories: Neuronal diseases

Aliases & Classifications for Temporal Lobe Epilepsy

Aliases & Descriptions for Temporal Lobe Epilepsy:

Name: Temporal Lobe Epilepsy 38 12 14
Epilepsy, Temporal Lobe 12 42 69
Epilepsy Temporal Lobe 52

Classifications:



External Ids:

Disease Ontology 12 DOID:3328
MeSH 42 D004833
UMLS 69 C0014556

Summaries for Temporal Lobe Epilepsy

MalaCards based summary : Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to idiopathic generalized epilepsy and personality disorder, and has symptoms including seizures and seizures, focal. An important gene associated with Temporal Lobe Epilepsy is RELN (Reelin), and among its related pathways/superpathways are Transmission across Chemical Synapses and cAMP signaling pathway. The drugs Citalopram and Amitriptyline have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and amygdala, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 71 Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system characterized by recurrent,... more...

Related Diseases for Temporal Lobe Epilepsy

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
id Related Disease Score Top Affiliating Genes
1 idiopathic generalized epilepsy 29.8 BDNF CALB1 GFAP LGI1 NPY PVALB
2 personality disorder 29.6 BDNF GAD1 HTR1A PDYN PVALB RELN
3 schizophrenia 28.7 BDNF CALB1 GABBR1 GAD1 GRIK1 HTR1A
4 mesial temporal lobe epilepsy with hippocampal sclerosis 12.2
5 infantile-onset mesial temporal lobe epilepsy with severe cognitive regression 12.1
6 benign familial mesial temporal lobe epilepsy 12.1
7 epilepsy, familial temporal lobe, 1 12.0
8 epilepsy, familial temporal lobe, 2 11.8
9 epilepsy, familial temporal lobe, 7 11.8
10 epilepsy, familial temporal lobe, 3 11.8
11 epilepsy, familial temporal lobe, 5 11.7
12 epilepsy, familial temporal lobe, 4 11.7
13 epilepsy, familial temporal lobe, 8 11.6
14 epilepsy, familial temporal lobe, 6 11.6
15 autosomal dominant partial epilepsy with auditory features 11.3
16 urbach-wiethe disease 11.3
17 epilepsy 11.2
18 temporal epilepsy, familial 11.1
19 autosomal dominant epilepsy with auditory features 11.1
20 febrile seizures, familial, 11 11.1
21 epilepsy, familial focal with variable foci 2 11.0
22 mental retardation, anterior maxillary protrusion, and strabismus 11.0
23 neuronitis 10.5
24 berardinelli-seip congenital lipodystrophy 10.3 LGI1 RELN
25 febrile seizures 10.3
26 status epilepticus 10.3
27 neurogenic thoracic outlet syndrome 10.3 LGI1 RELN
28 cancerophobia 10.2 CALB1 PVALB
29 postencephalitic parkinson disease 10.2 BDNF HTR1A TSPO
30 thrombocythemia 3 10.2 SLC1A2 SLC1A3
31 cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk 10.2 BDNF PVALB SLC1A3
32 persistent vegetative state 10.2 CALB1 PVALB RELN
33 encephalitis 10.2
34 ovarian mucinous adenocarcinoma 10.2 BDNF GFAP SLC1A2
35 severe intellectual disability-progressive spastic diplegia syndrome 10.2 GABBR1 GABBR2
36 cerebritis 10.1
37 chronic conjunctivitis 10.1 BDNF GAD1 HTR1A RELN
38 hepatitis d 10.1 BDNF HTR1A NPY TSPO
39 limbic encephalitis 10.1
40 encephalocele 10.1
41 brain glioblastoma multiforme 10.1 BDNF GAD1 HTR1A RELN
42 siberian tick typhus 10.1 BDNF HTR1A LGI1 PDYN TSPO
43 mucopolysaccharidosis iv 10.1 BDNF PVALB SLC1A2
44 meconium aspiration syndrome 10.1 HTR1A PDYN
45 ovarian cancer 10.1 GAD1 GFAP SLC1A2 SLC1A3
46 plantar fasciitis 10.1 GFAP LGI1 TSPO
47 syncope 10.0
48 preeclampsia/eclampsia 5 10.0 BDNF GABBR1 GAD1 HTR1A NPY PDYN
49 parametritis 10.0
50 mononeuritis multiplex 10.0 GABBR1 GAD1 LGI1 RELN SCN1B

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to Temporal Lobe Epilepsy

Symptoms & Phenotypes for Temporal Lobe Epilepsy

UMLS symptoms related to Temporal Lobe Epilepsy:


seizures, seizures, focal

MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.41 PVALB RELN SCN1B SLC1A2 SLC1A3 SV2B
2 growth/size/body region MP:0005378 10.24 GABBR1 GABBR2 GAD1 GFAP GRIK1 LGI1
3 mortality/aging MP:0010768 10.13 GAD1 GFAP HTR1A LGI1 PVALB RELN
4 nervous system MP:0003631 10.13 ACOT7 BDNF CALB1 CASP2 GABBR1 GABBR2
5 cellular MP:0005384 10.1 BDNF CASP2 GAD1 GFAP PVALB RELN
6 homeostasis/metabolism MP:0005376 10.1 ACOT7 BDNF GABBR1 GABBR2 GAD1 GFAP
7 no phenotypic analysis MP:0003012 9.5 SCN1B SLC1A3 BDNF GAD1 HTR1A PDYN
8 normal MP:0002873 9.36 GFAP GRIK1 NPY PVALB SCN1B SLC1A2

Drugs & Therapeutics for Temporal Lobe Epilepsy

Drugs for Temporal Lobe Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4 59729-33-8 2771
2
Amitriptyline Approved Phase 4 50-48-6 2160
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Perphenazine Approved Phase 4 58-39-9 4748
5 Antidepressive Agents Phase 4
6 Antidepressive Agents, Second-Generation Phase 4
7 Antiparkinson Agents Phase 4
8 Autonomic Agents Phase 4,Phase 3
9 Cholinergic Agents Phase 4
10 Cholinergic Antagonists Phase 4
11 Muscarinic Antagonists Phase 4
12 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
13 Neurotransmitter Uptake Inhibitors Phase 4
14 Parasympatholytics Phase 4
15 Peripheral Nervous System Agents Phase 4,Phase 3
16 Psychotropic Drugs Phase 4,Phase 1,Phase 2
17
Serotonin Phase 4,Phase 2 50-67-9 5202
18 Serotonin Agents Phase 4,Phase 2
19 Serotonin Uptake Inhibitors Phase 4
20 Central Nervous System Depressants Phase 4,Phase 1,Phase 2
21 Tranquilizing Agents Phase 4,Phase 1,Phase 2
22 Anesthetics Phase 4,Phase 3
23 Adrenergic Agents Phase 4
24 Amitriptyline, perphenazine drug combination Phase 4
25 Analgesics Phase 4
26 Analgesics, Non-Narcotic Phase 4
27 Anesthetics, Local Phase 4
28 Anti-Arrhythmia Agents Phase 4
29 Antidepressive Agents, Tricyclic Phase 4
30 Antipsychotic Agents Phase 4
31 Diuretics, Potassium Sparing Phase 4
32 Sodium Channel Blockers Phase 4
33
Menthol Approved Phase 3 2216-51-5 16666
34
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
35 Anticonvulsants Phase 3,Phase 2,Phase 1
36 Antiemetics Phase 3
37 Anti-Inflammatory Agents Phase 3
38 Antineoplastic Agents, Hormonal Phase 3
39 BB 1101 Phase 3
40 Dexamethasone 21-phosphate Phase 3
41 Dexamethasone acetate Phase 3 1177-87-3
42 Gastrointestinal Agents Phase 3
43 glucocorticoids Phase 3
44 HIV Protease Inhibitors Phase 3
45 Hormone Antagonists Phase 3
46 Hormones Phase 3
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
48
protease inhibitors Phase 3
49 Piracetam Approved Phase 2 7491-74-9
50
Valproic Acid Approved, Investigational Phase 1, Phase 2 99-66-1 3121

Interventional clinical trials:

(show top 50) (show all 52)
id Name Status NCT ID Phase
1 Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy Completed NCT00595699 Phase 4
2 Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines Enrolling by invitation NCT02090998 Phase 4
3 Early Surgical Intervention to Treat Epilepsy Completed NCT00040326 Phase 3
4 Radiosurgery or Open Surgery for Epilepsy Trial Active, not recruiting NCT00860145 Phase 3
5 Dexamethasone in Herpes Simplex Virus Encephalitis Not yet recruiting NCT03084783 Phase 3
6 A Multicenter Study of Hippocampal Electrical Stimulation (HS, in Mesial Temporal Lobe Epilepsy Terminated NCT00717431 Phase 3
7 Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI) Completed NCT01044758 Phase 2
8 A Dose Ranging Pilot Study to Assess Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures Recruiting NCT02899611 Phase 1, Phase 2
9 PRX-00023 Therapy in Localization-Related Epilepsy Enrolling by invitation NCT01281956 Phase 2
10 Buspirone Therapy for Localized Epilepsy Terminated NCT01496612 Phase 2
11 Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy Completed NCT00916266 Phase 1
12 Efficacy of TDCS for Treating Working Memory Dysfunction and Depression in Temporal Lobe Epilepsy Withdrawn NCT02268578 Phase 1
13 Controlled Randomized Stimulation Versus Resection (CoRaStiR) Unknown status NCT00431457
14 Emotional Processing and Memory Evaluation in Epilepsy Patients Unknown status NCT00486239 Early Phase 1
15 CBT Versus Selective Serotonin Reuptake Inhibitor For Treatment Of Depression In Temporal Lobe Epilepsy Patients Completed NCT02262156
16 Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy Completed NCT01563627
17 Study of [11C]DPA-713 for Temporal Lobe Epilepsy Completed NCT01793532
18 Language and Emotional Function in Patients With Temporal Lobe Epilepsy Completed NCT00081432
19 GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression Completed NCT00931619
20 Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy Completed NCT00001672
21 Electrical Brain Stimulation to Reduce Epileptic Seizures Completed NCT00344877
22 Light Scattering Spectroscopy to Determine Brain Tumors Completed NCT00067418
23 Language Mapping in Patients With Epilepsy Completed NCT00706160
24 Does Memantine Improve Verbal Memory Task Performance in Subjects With Partial Epilepsy and Memory Dysfunction? Completed NCT01054599
25 Neocortical Epilepsies - Do They Progress? Completed NCT00610558
26 Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery Completed NCT03102957
27 Arterial Spin Labeling MRI Focal Abnormalities in Refractory Epilepsy Completed NCT01772654
28 MRI in Autosomal Dominant Partial Epilepsy With Auditory Features Completed NCT00072813
29 Serotonin Receptors in Seizure Disorders Completed NCT00001932
30 The Rolandic Epilepsy/ESES/Landau-Kleffner Syndrome and Correlation With Language Impairment Study Completed NCT01335425
31 Low-intensity Focused Ultrasound Pulsation (LIFUP) for Treatment of Temporal Lobe Epilepsy Recruiting NCT02151175
32 Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE) Recruiting NCT02383407
33 Stereotactic Laser Ablation for Temporal Lobe Epilepsy Recruiting NCT02844465
34 Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation Recruiting NCT02339376
35 Low Frequency TMS for Depression in Epilepsy Recruiting NCT03105700
36 Surgery as a Treatment for Medically Intractable Epilepsy Recruiting NCT01273129
37 Feasibility Study on LITT for Medical Refractory Epilepsy Recruiting NCT02820740
38 Brain P-gp and Inflammation in People With Epilepsy Recruiting NCT01663545
39 fMRI Guided TMS Enhancement of Associative Memory Networks Recruiting NCT02749422
40 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Recruiting NCT02796287
41 Evaluation and Treatment of Patients With Epilepsy Recruiting NCT00013845
42 Single Neurons Responses During Visual Recognition in Epileptic Patients Recruiting NCT02877576
43 Heart Rate Variability (HRV) Analysis in Patients With Nocturnal Epileptic Seizures Recruiting NCT02469844
44 Study of Specimens Obtained During Epilepsy Surgery Recruiting NCT00025714
45 Functional Link Between Hippocampal and Vestibular Systems: a Pilot Study in Epilepsy Surgery Active, not recruiting NCT01285921
46 Controlled Randomized Vagus Nerve Stimulation (VNS) Therapy Versus Resection (CoRaVNStiR) Not yet recruiting NCT02089243
47 Subcutaneous EEG in Epilepsy Not yet recruiting NCT02946151
48 Application of Diffusion Tensor Imaging and Tractography in Epilepsy Surgery Not yet recruiting NCT02590419
49 COMETE Study : COgnitive Rehabilitation of MEmory in Temporal Epilepsy Not yet recruiting NCT02589470
50 Near Death Experience (NDE) and Migraine Not yet recruiting NCT02854930

Search NIH Clinical Center for Temporal Lobe Epilepsy

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: epilepsy, temporal lobe

Genetic Tests for Temporal Lobe Epilepsy

Anatomical Context for Temporal Lobe Epilepsy

MalaCards organs/tissues related to Temporal Lobe Epilepsy:

39
Temporal Lobe, Brain, Amygdala, Cortex, Bone, Testes, Heart

Publications for Temporal Lobe Epilepsy

Articles related to Temporal Lobe Epilepsy:

(show top 50) (show all 980)
id Title Authors Year
1
Genome-Wide DNA Methylation Patterns Analysis of Noncoding RNAs in Temporal Lobe Epilepsy Patients. ( 28058582 )
2017
2
Immunohistochemical study of Metallothionein in patients with temporal lobe epilepsy. ( 28087193 )
2017
3
A Prediction Algorithm for Drug Response in Patients with Mesial Temporal Lobe Epilepsy Based on Clinical and Genetic Information. ( 28052106 )
2017
4
Altered Expression of CXCL13 and CXCR5 in Intractable Temporal Lobe Epilepsy Patients and Pilocarpine-Induced Epileptic Rats. ( 27873133 )
2017
5
Rabies Tracing of Birthdated Dentate Granule Cells in Rat Temporal Lobe Epilepsy. ( 28470680 )
2017
6
Lack of heart rate variability during sleep-related apnea in patients with temporal lobe epilepsy (TLE)-an indirect marker of SUDEP? ( 28091857 )
2017
7
Severe intermittent anxiety attacks. A diagnosis challenge in temporal lobe epilepsy. ( 28064331 )
2017
8
Sex differences in verbal and nonverbal learning before and after temporal lobe epilepsy surgery. ( 28033547 )
2017
9
Preoperative automated fibre quantification predicts postoperative seizure outcome in temporal lobe epilepsy. ( 28031219 )
2017
10
Navigation-assisted trans-inferotemporal cortex selective amygdalohippocampectomy for mesial temporal lobe epilepsy; preserving the temporal stem. ( 28067149 )
2017
11
Smad anchor for receptor activation contributes to seizures in temporal lobe epilepsy. ( 28035691 )
2017
12
Editorial: Limbic Encephalitis: Autoimmune Impact on Inhibitory GABAergic Neuronal Pathways in Temporal Lobe Epilepsy. ( 27014186 )
2016
13
In response: Brain atrophy in seizure-free temporal lobe epilepsy: Implications for predicting pharmacoresistance. ( 27160803 )
2016
14
Naringenin ameliorates kainic acid-induced morphological alterations in the dentate gyrus in a mouse model of temporal lobe epilepsy. ( 27584687 )
2016
15
Effects of Swimming Exercise on Learning and Memory in the Kainate-Lesion Model of Temporal Lobe Epilepsy. ( 28050361 )
2016
16
Prevalence and incidence of drug-resistant mesial temporal lobe epilepsy in the United States. ( 28034810 )
2016
17
Systemic lupus erythematosus manifested as drug-resistant mesial temporal lobe epilepsy. ( 27592110 )
2016
18
Interictal serum brain-derived neurotrophic factor level reflects white matter integrity, epilepsy severity, and cognitive dysfunction in chronic temporal lobe epilepsy. ( 27152461 )
2016
19
Usage of SWI (susceptibility weighted imaging) acquired at 7T for qualitative evaluation of temporal lobe epilepsy patients with histopathological and clinical correlation: An initial pilot study. ( 27653870 )
2016
20
Exploring psychiatric comorbidities and their effects on quality of life in patients with temporal lobe epilepsy and juvenile myoclonic epilepsy. ( 28025856 )
2016
21
Alteration of the alertness-related network in patients with right temporal lobe epilepsy: A resting state fMRI study. ( 27661438 )
2016
22
Interhemispheric functional and structural alterations and their relationships with alertness in unilateral temporal lobe epilepsy. ( 27160125 )
2016
23
Large-scale brain networks are distinctly affected in right and left mesial temporal lobe epilepsy. ( 27133613 )
2016
24
Investigation of hippocampal substructures in focal temporal lobe epilepsy with and without hippocampal sclerosis at 7T. ( 27564217 )
2016
25
An SNP site in pri-miR-124, a brain expressed miRNA gene, no contribution to mesial temporal lobe epilepsy in an Italian sample. ( 27188998 )
2016
26
Social cognition in temporal lobe epilepsy: A systematic review and meta-analysis. ( 27179192 )
2016
27
Does antiepileptic drug withdrawal predispose patients undergoing temporal lobe epilepsy surgery to late onset of psychiatric morbidity? A report of three cases. ( 27570392 )
2016
28
Epilepsy: Tau pathology found in temporal lobe epilepsy. ( 27562549 )
2016
29
Hippocampal malrotation is an anatomic variant and has no clinical significance in MRI-negative temporal lobe epilepsy. ( 27562507 )
2016
30
Brain atrophy in seizure-free temporal lobe epilepsy: Implications for predicting pharmacoresistance. ( 27160802 )
2016
31
Screening LGI1 in a cohort of 26 lateral temporal lobe epilepsy patients with auditory aura from Turkey detects a novel de novo mutation. ( 26773249 )
2016
32
Gray Matter Abnormalities in Temporal Lobe Epilepsy: Relationships with Resting-State Functional Connectivity and Episodic Memory Performance. ( 27171178 )
2016
33
Mesial temporal lobe epilepsy with hippocampal sclerosis as a neuroimmunological disorder. ( 27170276 )
2016
34
The impact of intelligence on memory and executive functions of children with temporal lobe epilepsy: Methodological concerns with clinical relevance. ( 28089585 )
2016
35
Contribution of NRG1 Gene Polymorphisms in Temporal Lobe Epilepsy. ( 26071373 )
2016
36
MBD3 expression and DNA binding patterns are altered in a rat model of temporal lobe epilepsy. ( 27650712 )
2016
37
Lithium therapy in comorbid temporal lobe epilepsy and cycloid psychosis. ( 28031853 )
2016
38
Auditory temporal processing in patients with temporal lobe epilepsy. ( 27179714 )
2016
39
More Severe Extratemporal Damages in Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis Than That With Other Lesions: A Multimodality MRI Study. ( 26962820 )
2016
40
Neuronal autoantibodies in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 27151964 )
2016
41
Long-term drug-resistant temporal lobe epilepsy associated with a mixed ganglioglioma and dysembryoplastic neuroepithelial tumor in an elderly patient. ( 27127715 )
2016
42
Temporal lobe epilepsy associated with GAD autoimmunity. ( 27638303 )
2016
43
Electrophysiological resting-state biomarker for diagnosing mesial temporal lobe epilepsy with hippocampal sclerosis. ( 28043064 )
2016
44
Optimizing memory function in temporal lobe epilepsy. ( 27164312 )
2016
45
Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy. ( 27162079 )
2016
46
Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy Patients. ( 28018680 )
2016
47
Prognostic factors for seizure outcome in patients with MRI-negative temporal lobe epilepsy: A meta-analysis and systematic review. ( 27182689 )
2016
48
Down-regulation of adenylate kinase 5 in temporal lobe epilepsy patients and rat model. ( 27288770 )
2016
49
Apolipoprotein E I/4 Allele was Associated With Nonlesional Mesial Temporal Lobe Epilepsy in Han Chinese Population. ( 26945380 )
2016
50
White matter abnormalities in patients with temporal lobe epilepsy and amygdala enlargement: Comparison with hippocampal sclerosis and healthy subjects. ( 27635630 )
2016

Variations for Temporal Lobe Epilepsy

Expression for Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for Temporal Lobe Epilepsy

GO Terms for Temporal Lobe Epilepsy

Cellular components related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.46 CALB1 GAD1 PVALB SLC1A2
2 synapse GO:0045202 9.17 CALB1 GABBR1 GABBR2 GAD1 GRIK1 LGI1
3 G-protein coupled receptor heterodimeric complex GO:0038039 8.96 GABBR1 GABBR2

Biological processes related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.92 GRIK1 SCN1B SLC1A2 SLC1A3 TSPO
2 response to drug GO:0042493 9.81 GAD1 SLC1A2 SLC1A3 TSPO
3 axon guidance GO:0007411 9.62 BDNF LGI1 RELN SCN1B
4 response to pain GO:0048265 9.49 RELN TSPO
5 positive regulation of synaptic transmission GO:0050806 9.48 LGI1 SLC1A3
6 L-glutamate transmembrane transport GO:0089711 9.46 SLC1A2 SLC1A3
7 behavior GO:0007610 9.43 HTR1A NPY
8 L-glutamate transport GO:0015813 9.4 SLC1A2 SLC1A3
9 regulation of behavior GO:0050795 9.37 HTR1A RELN
10 D-aspartate import GO:0070779 9.26 SLC1A2 SLC1A3
11 chemical synaptic transmission GO:0007268 9.23 GABBR2 GAD1 GRIK1 NPY PDYN SCN1B
12 L-glutamate import GO:0051938 9.16 SLC1A2 SLC1A3
13 gamma-aminobutyric acid biosynthetic process GO:0009449 8.96 GAD1 SLC1A3

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 L-glutamate transmembrane transporter activity GO:0005313 9.32 SLC1A2 SLC1A3
2 glutamate binding GO:0016595 9.26 GAD1 SLC1A3
3 high-affinity glutamate transmembrane transporter activity GO:0005314 9.16 SLC1A2 SLC1A3
4 G-protein coupled GABA receptor activity GO:0004965 8.96 GABBR1 GABBR2
5 glutamate:sodium symporter activity GO:0015501 8.62 SLC1A2 SLC1A3

Sources for Temporal Lobe Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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