MCID: TMP001
MIFTS: 57

Temporal Lobe Epilepsy malady

Summaries for Temporal Lobe Epilepsy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Temporal lobe epilepsy is a form of focal epilepsy, a chronic neurological condition characterized by... more...

MalaCards: Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to febrile seizures and memory impairment. An important gene associated with Temporal Lobe Epilepsy is CASP2 (caspase 2, apoptosis-related cysteine peptidase). The drugs phenytoin and phenytoin sodium and the compounds glutamate and nmda have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are nervous system and mortality/aging.

Aliases & Classifications for Temporal Lobe Epilepsy

Sources:
8Disease Ontology, 31LifeMap Discovery™, 61UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

temporal lobe epilepsy 8 31
epilepsy, temporal lobe 8 61
epilepsy temporal lobe 45


External Ids:

Disease Ontology8 DOID:3328
MeSH35 D004833

Related Diseases for Temporal Lobe Epilepsy

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Temporal Lobe Epilepsy family:

epilepsy, familial temporal lobe, 5 epilepsy, familial temporal lobe, 4
epilepsy, familial temporal lobe, 1 epilepsy, familial temporal lobe, 2

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1febrile seizures31.1SCN1B, LGI1
2memory impairment30.8PDYN, HTR1A, APOE, TSPO
3obsessive-compulsive disorder30.2TSPO, HTR1A, PDYN
4temporal epilepsy, familial10.8
5status epilepticus10.7
6frontal lobe epilepsy10.7
7epilepsy, familial mesial temporal lobe10.5
8epilepsy, familial temporal lobe, 110.5
9autosomal dominant partial epilepsy with auditory features10.5
10encephalocele10.5
11limbic encephalitis10.5
12syncope10.5
13benign familial mesial temporal lobe epilepsy10.5
14lateral sclerosis10.4
15visual epilepsy10.4
16chorea-acanthocytosis10.4
17acanthocytosis10.4
18chorea10.4
19encephaloceles10.4
20seizure disorder10.4
21transvestism10.3
22n syndrome10.3
23juvenile myoclonic epilepsy10.3
24tetanus10.3
25autonomic dysfunction10.3
26mesial temporal lobe epilepsy with hippocampal sclerosis10.3
27transient global amnesia10.2
28capgras syndrome10.2
29choroid plexus papilloma10.2
30major depressive disorder10.2
31dysembryoplastic neuroepithelial tumor10.2
32cysticercosis10.2
33eclampsia10.2
34alexia10.2
35asperger syndrome10.2
36periventricular nodular heterotopia10.2
37systemic lupus erythematosus10.2
38west syndrome10.2
39ganglioglioma10.2
40myxopapillary ependymoma10.2
41temporal lobe neoplasm10.2
42cerebral malaria10.2
43insulinoma10.2
44acute leukemia10.2
45spinocerebellar ataxia10.2
46spastic paraplegia 110.2
47spastic paraplegia 1010.2
48ependymoma10.2
49postural orthostatic tachycardia syndrome10.2
50herpes simplex encephalitis10.2

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to temporal lobe epilepsy

Clinical Features for Temporal Lobe Epilepsy

Drugs & Therapeutics for Temporal Lobe Epilepsy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Temporal Lobe Epilepsy

Drug clinical trials:

Search ClinicalTrials for Temporal Lobe Epilepsy

Search NIH Clinical Center for Temporal Lobe Epilepsy

Search CenterWatch for Temporal Lobe Epilepsy

Inferred drug relations via UMLS61/NDF-RT41:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Genetic Tests for Temporal Lobe Epilepsy

Anatomical Context for Temporal Lobe Epilepsy

Sources:
33MalaCards
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MalaCards organs/tissues related to Temporal Lobe Epilepsy:

33
Bone marrow, Whole blood, Brain, Cortex, Cerebellum, Heart, Thyroid, Skin, B lymphoblasts, B cells, Prefrontal cortex, Temporal lobe, Olfactory bulb, Amygdala

Animal Models for Temporal Lobe Epilepsy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.2LGI4, PVALB, CALHM1, CASP2, PDYN, HTR1A
2MP:001076811.1GABBR1, SCN1B, APOE, HTR1A, DBP, RELN
3MP:000538610.8PVALB, PDYN, HTR1A, APOE, SCN1B, GABBR1

Publications for Temporal Lobe Epilepsy

Sources:
51PubMed
See all sources

Articles related to Temporal Lobe Epilepsy:

(show top 50)    (show all 839)
idTitleAuthorsYear
1
Subtle temporal lobe epilepsy with headache as the major complaint: what can we learn from the long-delayed diagnosis? (23290451)
2013
2
Word-finding difficulties confound performance on verbal cognitive measures in adults with intractable left temporal lobe epilepsy. (23360444)
2013
3
Detection of hippocampal atrophy in patients with temporal lobe epilepsy: a 3-Tesla MRI shape. (23892579)
2013
4
Tenidap, an agonist of the inwardly rectifying K+ channel Kir2.3, delays the onset of cortical epileptiform activity in a model of chronic temporal lobe epilepsy. (23561319)
2013
5
The overall pathological status of the left hippocampus determines preoperative verbal memory performance in left mesial temporal lobe epilepsy. (24375772)
2013
6
Urokinase-type plasminogen activator receptor modulates epileptogenesis in mouse model of temporal lobe epilepsy. (23263886)
2013
7
Clinical phenotypes within non-surgical patients with mesial temporal lobe epilepsy caused by hippocampal sclerosis based on response to antiepileptic drugs. (23041032)
2013
8
Predicting and preventing psychopathology following temporal lobe epilepsy surgery. (23246146)
2013
9
Investigating higher-order cognitive functions in temporal lobe epilepsy: cognitive estimation. (24012509)
2013
10
Famous face identification in temporal lobe epilepsy: support for a multimodal integration model of semantic memory. (23040175)
2013
11
Slowly evolving trends in temporal lobe epilepsy management at london health sciences centre. (23533736)
2013
12
Selective amygdalohippocampectomy versus standard temporal lobectomy in patients with mesial temporal lobe epilepsy and unilateral hippocampal sclerosis. (23022178)
2013
13
Rhythmic ictal nonclonic hand (RINCH) motions in temporal lobe epilepsy: invasive EEG findings, incidence, and lateralizing value. (23928193)
2013
14
"TOR"-ing Down the Dentate Gate in Temporal Lobe Epilepsy. (24348120)
2013
15
Suggestive linkage of familial mesial temporal lobe epilepsy to chromosome 3q26. (24315020)
2013
16
Pharmacological blockade of IL-1I^/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy. (23938763)
2013
17
Seizure outcome in surgically treated drug-resistant mesial temporal lobe epilepsy based on the recent histopathological classifications. (23641822)
2013
18
Amygdala enlargement occurs in patients with mesial temporal lobe epilepsy and hippocampal sclerosis with early epilepsy onset. (24074891)
2013
19
Should patients be routinely assessed for cerebral vasospasm after temporal lobe epilepsy surgery? (22442435)
2012
20
Neuropathology of temporal lobe epilepsy. (22957233)
2012
21
Interleukin-1I^ and microRNA-146a in an immature rat model and children with mesial temporal lobe epilepsy. (22708826)
2012
22
Functional magnetic resonance imaging for language mapping in temporal lobe epilepsy. (22934161)
2012
23
Involvement of 5-HTa88 receptors in the pathogenesis of temporal lobe epilepsy. (22543085)
2012
24
Surgical techniques for the treatment of temporal lobe epilepsy. (22957228)
2012
25
The role of voxel-based morphometry in the detection of cortical dysplasia within the temporal pole in patients with intractable mesial temporal lobe epilepsy. (22510082)
2012
26
Microsurgical anatomy of the temporal lobe and its implications on temporal lobe epilepsy surgery. (22957242)
2012
27
Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats. (22720001)
2012
28
Neocortical temporal lobe epilepsy. (22953057)
2012
29
Kallikrein 1 is overexpressed by astrocytes in the hippocampus of patients with refractory temporal lobe epilepsy, associated with hippocampal sclerosis. (21211543)
2011
30
Abnormal expression of netrin-G2 in temporal lobe epilepsy neurons in humans and a rat model. (20382146)
2010
31
Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: the first report from Asian families. (19780791)
2010
32
Extent of initial injury determines language lateralization in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). (19744113)
2009
33
Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy. (19285131)
2009
34
Transcriptionally less active prodynorphin promoter alleles are associated with temporal lobe epilepsy: a case-control study and meta-analysis. (18334734)
2008
35
Upregulated expression of postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA in temporal lobe tissue of epilepsy. (17506987)
2007
36
The syndrome of mesial temporal lobe epilepsy with hippocampal sclerosis: clinical features and differential diagnosis. (16383112)
2006
37
Endoplasmic reticulum stress and apoptosis signaling in human temporal lobe epilepsy. (16651883)
2006
38
Decreased expression of thyroid receptor-associated protein 220 in temporal lobe tissue of patients with refractory epilepsy. (16934225)
2006
39
GABA receptor 1 polymorphism (G1465A) and temporal lobe epilepsy. (15946333)
2005
40
Asymmetry of long-latency auditory evoked potentials in LGI1-related autosomal dominant lateral temporal lobe epilepsy. (16190946)
2005
41
Transient downregulation of Sema3A mRNA in a rat model for temporal lobe epilepsy. A novel molecular event potentially contributing to mossy fiber sprouting. (12821384)
2003
42
Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. (12122039)
2002
43
Chromogranins in temporal lobe epilepsy. (10999531)
2000
44
Early loss of interneurons and delayed subunit-specific changes in GABA(A)-receptor expression in a mouse model of mesial temporal lobe epilepsy. (10902900)
2000
45
Generalised cerebral atrophy following temporal lobectomy for intractable epilepsy associated with mesial temporal sclerosis. (10745135)
2000
46
Disturbances of amino acids from temporal lobe synaptosomes in human complex partial epilepsy. (10555778)
1999
47
Neuropeptide Y expression in animal models of temporal lobe epilepsy. (9302518)
1996
48
Interictal metabolism and blood flow are uncoupled in temporal lobe cortex of patients with complex partial epilepsy. (7477979)
1995
49
Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. (7472396)
1995
50
Transient global amnesia: manifestation of medial temporal lobe epilepsy. (455733)
1979

Genetic Variations for Temporal Lobe Epilepsy

Expression for genes affiliated with Temporal Lobe Epilepsy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for genes affiliated with Temporal Lobe Epilepsy

Compounds for genes affiliated with Temporal Lobe Epilepsy

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1glutamate4511.3PVALB, PDYN, APOE, GABBR1, RELN, SLC12A5
2nmda45 2912.2TSPO, GABBR1, APOE, HTR1A, PDYN, PVALB
3gaba4511.2PVALB, PDYN, GABBR1, RELN, SLC12A5, TSPO
4acetylcholine45 50 29 11 2415.2PVALB, PDYN, HTR1A, APOE, GABBR1, TSPO
5dopamine45 29 11 2414.2PVALB, PDYN, HTR1A, APOE, GABBR1, TSPO
6kainate45 2912.2PVALB, PDYN, APOE, GABBR1, TSPO
7potassium45 11 2413.1LGI1, GABBR1, SCN1B, PDYN, CASP2
8morphine45 50 29 1114.1TSPO, GABBR1, PDYN, CASP2
9pentylenetetrazol4511.0TSPO, GABBR1, PDYN
10chloride4511.0TSPO, SLC12A5, GABBR1, PVALB
11bicuculline45 2912.0TSPO, SLC12A5, GABBR1
12naloxone45 50 29 1114.0PDYN, GABBR1, TSPO
13tetrodotoxin45 60 2913.0PVALB, APOE, SCN1B
14opiate4511.0TSPO, GABBR1, PDYN
15ethanol45 50 11 2414.0PVALB, CASP2, PDYN, GABBR1
16abecarnil4511.0HTR1A, TSPO
17levodopa45 1111.9TSPO, HTR1A, PDYN
18carbon-114510.9TSPO, HTR1A
19norepinephrine45 11 2412.9PDYN, HTR1A, GABBR1, TSPO
20dodecylphosphocholine4510.9PDYN, APOE
21benzodiazepines4510.9TSPO, GABBR1
22haloperidol45 29 2 50 1114.9TSPO, HTR1A, PVALB
23buspirone45 29 1112.9HTR1A, TSPO
24damgo45 60 2912.9PDYN, GABBR1
25gamma-hydroxybutyrate4510.8TSPO, GABBR1
26baclofen45 1111.7GABBR1, TSPO
2722r-hydroxycholesterol45 2911.7APOE, TSPO
28dimyristoylphosphatidylcholine4510.7APOE, PDYN
295-hydroxytryptamine4510.7TSPO, GABBR1, HTR1A
30scopolamine45 29 11 2413.6TSPO, HTR1A
31cocaine45 1111.6PDYN, GABBR1, TSPO
32fluvoxamine45 50 1112.3TSPO, HTR1A

GO Terms for genes affiliated with Temporal Lobe Epilepsy

Sources:
16Gene Ontology
See all sources

Biological processes related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726810.7PDYN, SCN1B, GABBR1, SLC12A5
2peripheral nervous system axon regenerationGO:01401210.6APOE, TSPO
3regulation of behaviorGO:05079510.5HTR1A, RELN
4agingGO:00756810.4CASP2, APOE, TSPO

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle receptor bindingGO:07032610.6RELN, APOE

Products for genes affiliated with Temporal Lobe Epilepsy

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Sources for Temporal Lobe Epilepsy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet