Aliases & Classifications for Temporal Lobe Epilepsy

MalaCards integrated aliases for Temporal Lobe Epilepsy:

Name: Temporal Lobe Epilepsy 38 12 14
Epilepsy, Temporal Lobe 12 42 69
Epilepsy Temporal Lobe 52

Classifications:



External Ids:

Disease Ontology 12 DOID:3328
MeSH 42 D004833
UMLS 69 C0014556

Summaries for Temporal Lobe Epilepsy

MalaCards based summary : Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to idiopathic generalized epilepsy and personality disorder, and has symptoms including seizures and seizures, focal. An important gene associated with Temporal Lobe Epilepsy is RELN (Reelin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Transmission across Chemical Synapses. The drugs Citalopram and Amitriptyline have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and bone, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 72 Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system characterized by recurrent,... more...

Related Diseases for Temporal Lobe Epilepsy

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
id Related Disease Score Top Affiliating Genes
1 idiopathic generalized epilepsy 29.6 BDNF CALB1 GFAP LGI1 NPY PVALB
2 personality disorder 29.5 BDNF GAD1 HTR1A PDYN PVALB RELN
3 schizophrenia 26.3 BDNF CALB1 GABBR1 GAD1 GRIK1 GRIN1
4 mesial temporal lobe epilepsy with hippocampal sclerosis 12.2
5 benign familial mesial temporal lobe epilepsy 12.1
6 infantile-onset mesial temporal lobe epilepsy with severe cognitive regression 12.1
7 epilepsy, familial temporal lobe, 1 11.9
8 epilepsy, familial temporal lobe, 2 11.9
9 epilepsy, familial temporal lobe, 3 11.8
10 epilepsy, familial temporal lobe, 7 11.8
11 epilepsy, familial temporal lobe, 4 11.7
12 epilepsy, familial temporal lobe, 6 11.6
13 epilepsy, familial temporal lobe, 5 11.6
14 epilepsy, familial temporal lobe, 8 11.6
15 autosomal dominant partial epilepsy with auditory features 11.3
16 urbach-wiethe disease 11.3
17 temporal epilepsy, familial 11.2
18 epilepsy 11.2
19 epilepsy, familial focal, with variable foci 3 11.1
20 epilepsy, familial focal, with variable foci 2 11.1
21 febrile seizures, familial, 11 11.1
22 autosomal dominant epilepsy with auditory features 11.1
23 mental retardation, anterior maxillary protrusion, and strabismus 11.0
24 middle ear neuroendocrine tumor 10.8 LGI1 RELN
25 meconium aspiration syndrome 10.6 HTR1A PDYN
26 adult central nervous system mature teratoma 10.6 CALB1 PVALB
27 postencephalitic parkinson disease 10.5 BDNF HTR1A TSPO
28 neuronitis 10.5
29 endotheliitis 10.5 BDNF PVALB SLC1A3
30 ovarian cystadenocarcinoma 10.5 BDNF GFAP SLC1A2
31 polycythemia vera, somatic 10.5 SLC1A2 SLC1A3
32 spondylosis 10.4 LGI1 PDYN TSPO
33 overuse syndrome 10.4 CALB1 PVALB RELN
34 seres-santamaria arimany muniz syndrome 10.4 GABBR1 GABBR2
35 active cochlear meniere's disease 10.4 BDNF LGI1
36 chronic conjunctivitis 10.4 BDNF GAD1 HTR1A RELN
37 spinal stenosis 10.4 BDNF GFAP GRIN1
38 lower urinary tract calculus 10.4 GFAP LGI1 TSPO
39 adenofibroma 10.4 GFAP GRIN1
40 hepatitis d 10.3 BDNF HTR1A NPY TSPO
41 autoimmune-related retinopathy and optic neuropathy 10.3 BDNF GAD1 HTR1A RELN
42 febrile seizures 10.3
43 status epilepticus 10.3
44 bone fracture 10.3 BDNF GAD1 HTR1A RELN
45 transsexualism 10.2 BDNF HTR1A LGI1 PDYN TSPO
46 partial motor epilepsy 10.2 BDNF HTR1A NPY
47 long bones of lower limb cancer 10.2 GABBR1 LGI1
48 iris disease 10.2 GAD1 GFAP SLC1A2 SLC1A3
49 encephalitis 10.2
50 craniosynostosis, adelaide type 10.2 BDNF HTR1A NPY SLC1A3

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to Temporal Lobe Epilepsy

Symptoms & Phenotypes for Temporal Lobe Epilepsy

UMLS symptoms related to Temporal Lobe Epilepsy:


seizures, seizures, focal

MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.43 LGI1 NPY PDYN PVALB RELN SCN1B
2 growth/size/body region MP:0005378 10.31 ACOT7 BDNF GABBR1 GABBR2 GAD1 GFAP
3 nervous system MP:0003631 10.23 SV2B ACOT7 BDNF CALB1 GABBR1 GABBR2
4 mortality/aging MP:0010768 10.2 GABBR2 GAD1 GFAP GRIN1 HTR1A LGI1
5 homeostasis/metabolism MP:0005376 10.18 HTR1A NPY PDYN SLC1A2 SLC1A3 TSPO
6 no phenotypic analysis MP:0003012 9.76 BDNF GAD1 GRIN1 HTR1A PDYN PVALB
7 normal MP:0002873 9.73 BDNF CALB1 GAD1 GFAP GRIK1 GRIN1
8 vision/eye MP:0005391 9.23 BDNF GFAP GRIN1 LGI1 RELN SCN1B

Drugs & Therapeutics for Temporal Lobe Epilepsy

Drugs for Temporal Lobe Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4 59729-33-8 2771
2
Amitriptyline Approved Phase 4 50-48-6 2160
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Perphenazine Approved Phase 4 58-39-9 4748
5 Antidepressive Agents Phase 4
6 Antidepressive Agents, Second-Generation Phase 4
7 Antiparkinson Agents Phase 4
8 Autonomic Agents Phase 4
9 Cholinergic Agents Phase 4
10 Cholinergic Antagonists Phase 4
11 Muscarinic Antagonists Phase 4
12 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
13 Neurotransmitter Uptake Inhibitors Phase 4
14 Parasympatholytics Phase 4
15 Peripheral Nervous System Agents Phase 4
16 Psychotropic Drugs Phase 4,Phase 1,Phase 2
17
Serotonin Phase 4,Phase 2 50-67-9 5202
18 Serotonin Agents Phase 4,Phase 2
19 Serotonin Uptake Inhibitors Phase 4
20 Central Nervous System Depressants Phase 4,Phase 1,Phase 2
21 Tranquilizing Agents Phase 4,Phase 1,Phase 2
22 Anesthetics Phase 4,Phase 3
23 Adrenergic Agents Phase 4
24 Amitriptyline, perphenazine drug combination Phase 4
25 Analgesics Phase 4
26 Analgesics, Non-Narcotic Phase 4
27 Anesthetics, Local Phase 4
28 Anti-Arrhythmia Agents Phase 4
29 Antidepressive Agents, Tricyclic Phase 4
30 Antipsychotic Agents Phase 4
31 Diuretics, Potassium Sparing Phase 4
32 Sodium Channel Blockers Phase 4
33
Menthol Approved Phase 3 2216-51-5 16666
34 Anticonvulsants Phase 3,Phase 1,Phase 2
35
Valproic Acid Approved, Investigational Phase 1, Phase 2 99-66-1 3121
36
Buspirone Approved, Investigational Phase 2 36505-84-7 2477
37 Antimanic Agents Phase 1, Phase 2
38 GABA Agents Phase 1, Phase 2
39 Anti-Anxiety Agents Phase 2
40 Naluzotan Phase 2
41 Serotonin 5-HT1 Receptor Agonists Phase 2
42
Sertraline Approved 79617-96-2 68617
43
Dopamine Approved 51-61-6, 62-31-7 681
44
Memantine Approved, Investigational 19982-08-2 4054
45
Glutamic Acid Approved, Nutraceutical 56-86-0 33032
46 Fluorides
47 Fluorodeoxyglucose F18
48 Dopamine Agents
49 Excitatory Amino Acid Antagonists
50 Excitatory Amino Acids

Interventional clinical trials:

(show all 50)

id Name Status NCT ID Phase Drugs
1 Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy Completed NCT00595699 Phase 4 escitalopram;placebo
2 Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines Enrolling by invitation NCT02090998 Phase 4 Amitriptyline
3 Early Surgical Intervention to Treat Epilepsy Completed NCT00040326 Phase 3 antiepileptic drugs
4 Radiosurgery or Open Surgery for Epilepsy Trial Active, not recruiting NCT00860145 Phase 3
5 A Multicenter Study of Hippocampal Electrical Stimulation (HS, in Mesial Temporal Lobe Epilepsy Terminated NCT00717431 Phase 3
6 A Dose Ranging Pilot Study to Assess Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures Recruiting NCT02899611 Phase 1, Phase 2 Valproate
7 Buspirone Therapy for Localized Epilepsy Terminated NCT01496612 Phase 2 Buspirone
8 PRX-00023 Therapy in Localization-Related Epilepsy Terminated NCT01281956 Phase 2 PRX-00023
9 Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy Completed NCT00916266 Phase 1
10 Efficacy of TDCS for Treating Working Memory Dysfunction and Depression in Temporal Lobe Epilepsy Withdrawn NCT02268578 Phase 1
11 Controlled Randomized Vagus Nerve Stimulation (VNS) Therapy Versus Resection (CoRaVNStiR) Unknown status NCT02089243
12 Application of Diffusion Tensor Imaging and Tractography in Epilepsy Surgery Unknown status NCT02590419
13 Controlled Randomized Stimulation Versus Resection (CoRaStiR) Unknown status NCT00431457
14 Emotional Processing and Memory Evaluation in Epilepsy Patients Unknown status NCT00486239 Early Phase 1
15 Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy Completed NCT01563627
16 Study of [11C]DPA-713 for Temporal Lobe Epilepsy Completed NCT01793532
17 Language and Emotional Function in Patients With Temporal Lobe Epilepsy Completed NCT00081432
18 CBT Versus Selective Serotonin Reuptake Inhibitor For Treatment Of Depression In Temporal Lobe Epilepsy Patients Completed NCT02262156 SSRI
19 GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression Completed NCT00931619
20 Electrical Brain Stimulation to Reduce Epileptic Seizures Completed NCT00344877
21 Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy Completed NCT00001672
22 Does Memantine Improve Verbal Memory Task Performance in Subjects With Partial Epilepsy and Memory Dysfunction? Completed NCT01054599 Memantine;Memantine
23 Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery Completed NCT03102957
24 Neocortical Epilepsies - Do They Progress? Completed NCT00610558
25 Light Scattering Spectroscopy to Determine Brain Tumors Completed NCT00067418
26 Brain P-gp and Inflammation in People With Epilepsy Completed NCT01663545
27 Arterial Spin Labeling MRI Focal Abnormalities in Refractory Epilepsy Completed NCT01772654
28 Language Mapping in Patients With Epilepsy Completed NCT00706160
29 MRI in Autosomal Dominant Partial Epilepsy With Auditory Features Completed NCT00072813
30 Serotonin Receptors in Seizure Disorders Completed NCT00001932
31 Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE) Recruiting NCT02383407
32 Stereotactic Laser Ablation for Temporal Lobe Epilepsy Recruiting NCT02844465
33 Low Frequency TMS for Depression in Epilepsy Recruiting NCT03105700
34 Low-intensity Focused Ultrasound Pulsation (LIFUP) for Treatment of Temporal Lobe Epilepsy Recruiting NCT02151175
35 Subcutaneous EEG in Epilepsy Recruiting NCT02946151
36 Feasibility Study on LITT for Medical Refractory Epilepsy Recruiting NCT02820740
37 Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation Recruiting NCT02339376
38 fMRI Guided TMS Enhancement of Associative Memory Networks Recruiting NCT02749422
39 Surgery as a Treatment for Medically Intractable Epilepsy Recruiting NCT01273129
40 Brain Network Activation Analysis in Epilepsy Recruiting NCT03265925
41 Evaluation and Treatment of Patients With Epilepsy Recruiting NCT00013845
42 Single Neurons Responses During Visual Recognition in Epileptic Patients Recruiting NCT02877576
43 Heart Rate Variability (HRV) Analysis in Patients With Nocturnal Epileptic Seizures Recruiting NCT02469844
44 Study of Specimens Obtained During Epilepsy Surgery Recruiting NCT00025714
45 Functional Link Between Hippocampal and Vestibular Systems: a Pilot Study in Epilepsy Surgery Active, not recruiting NCT01285921
46 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Active, not recruiting NCT02796287
47 COMETE Study : COgnitive Rehabilitation of MEmory in Temporal Epilepsy Not yet recruiting NCT02589470
48 Near Death Experience (NDE) and Migraine Not yet recruiting NCT02854930
49 The Utility of NIOM During LITT for Refractory MTLE Withdrawn NCT02913742
50 Efficacy and Safety of the Use of Memantine for Preserving Cognition in Adult Patients With Epilepsy Withdrawn NCT00986115 Memantine;Placebo

Search NIH Clinical Center for Temporal Lobe Epilepsy

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: epilepsy, temporal lobe

Genetic Tests for Temporal Lobe Epilepsy

Anatomical Context for Temporal Lobe Epilepsy

MalaCards organs/tissues related to Temporal Lobe Epilepsy:

39
Temporal Lobe, Brain, Bone, Amygdala, Cortex, Heart, Testes

Publications for Temporal Lobe Epilepsy

Articles related to Temporal Lobe Epilepsy:

(show top 50) (show all 1012)
id Title Authors Year
1
Hamartia in hippocampal sclerosis-associated mesial temporal lobe epilepsy. ( 28888331 )
2017
2
Navigation-assisted trans-inferotemporal cortex selective amygdalohippocampectomy for mesial temporal lobe epilepsy; preserving the temporal stem. ( 28067149 )
2017
3
TRIF contributes to epileptogenesis in temporal lobe epilepsy during TLR4 activation. ( 28867282 )
2017
4
Altered functional connectivity in mesial temporal lobe epilepsy. ( 28923408 )
2017
5
Psychogenic nonepileptic seizures in patients with surgically treated temporal lobe epilepsy: Presurgical and de novo postsurgical occurrence. ( 28867568 )
2017
6
Rabies Tracing of Birthdated Dentate Granule Cells in Rat Temporal Lobe Epilepsy. ( 28470680 )
2017
7
Deep brain stimulation for refractory temporal lobe epilepsy: a systematic review and meta-analysis with an emphasis on alleviation of seizure frequency outcome. ( 28921161 )
2017
8
Impact of hippocampal subfield histopathology in episodic memory impairment in mesial temporal lobe epilepsy and hippocampal sclerosis. ( 28873362 )
2017
9
MicroRNA and mesial temporal lobe epilepsy with hippocampal sclerosis: Whole miRNome profiling of human hippocampus. ( 28815576 )
2017
10
Pro-excitatory alterations in sodium channel activity facilitate subiculum neuron hyperexcitability in temporal lobe epilepsy. ( 28860087 )
2017
11
The role of presurgical EEG parameters and of reoperation for seizure outcome in temporal lobe epilepsy. ( 28888215 )
2017
12
Pharmacoresistance with newer anti-epileptic drugs in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 28941835 )
2017
13
Bilateral cingulum fiber reductions in temporal lobe epilepsy with unilateral hippocampal sclerosis. ( 28941760 )
2017
14
Immunohistochemical study of Metallothionein in patients with temporal lobe epilepsy. ( 28087193 )
2017
15
Morphometric MRI features are associated with surgical outcome in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 28324681 )
2017
16
Lack of heart rate variability during sleep-related apnea in patients with temporal lobe epilepsy (TLE)-an indirect marker of SUDEP? ( 28091857 )
2017
17
Decline in word-finding: The objective cognitive finding most relevant to patients after mesial temporal lobe epilepsy surgery. ( 28867574 )
2017
18
Comparing CAT12 and VBM8 for Detecting Brain Morphological Abnormalities in Temporal Lobe Epilepsy. ( 28883807 )
2017
19
Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model. ( 28239767 )
2017
20
Quantitative and qualitative analysis of semantic verbal fluency in patients with temporal lobe epilepsy. ( 28863828 )
2017
21
Hippocampal Atrophy Is Associated with Altered Hippocampus-Posterior Cingulate Cortex Connectivity in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. ( 28104639 )
2017
22
The clinical phenotype of autosomal dominant lateral temporal lobe epilepsy related to reelin mutations. ( 28142128 )
2017
23
Smad anchor for receptor activation contributes to seizures in temporal lobe epilepsy. ( 28035691 )
2017
24
Personalized structural image analysis in patients with temporal lobe epilepsy. ( 28883420 )
2017
25
Severe intermittent anxiety attacks. A diagnosis challenge in temporal lobe epilepsy. ( 28064331 )
2017
26
Immunogenetic Predisposing Factors for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. ( 28675059 )
2017
27
Relationship between neuronal network architecture and naming performance in temporal lobe epilepsy: A connectome based approach using machine learning. ( 28899551 )
2017
28
Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy. ( 28912503 )
2017
29
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. ( 28857179 )
2017
30
Genome-Wide DNA Methylation Patterns Analysis of Noncoding RNAs in Temporal Lobe Epilepsy Patients. ( 28058582 )
2017
31
Visual Deficit From Laser Interstitial Thermal Therapy for Temporal Lobe Epilepsy: Anatomical Considerations. ( 28922876 )
2017
32
Disconnection of hippocampal networks contributes to memory dysfunction in individuals with temporal lobe epilepsy. ( 28888031 )
2017
33
An epileptologist's view: Seizure-related outcomes after radiofrequency ablation for mesial temporal lobe epilepsy. ( 28927701 )
2017
34
NTRK2 (TrkB gene) variants and temporal lobe epilepsy: A genetic association study. ( 28863320 )
2017
35
Preoperative automated fibre quantification predicts postoperative seizure outcome in temporal lobe epilepsy. ( 28031219 )
2017
36
A Prediction Algorithm for Drug Response in Patients with Mesial Temporal Lobe Epilepsy Based on Clinical and Genetic Information. ( 28052106 )
2017
37
Altered Expression of CXCL13 and CXCR5 in Intractable Temporal Lobe Epilepsy Patients and Pilocarpine-Induced Epileptic Rats. ( 27873133 )
2017
38
Sex differences in verbal and nonverbal learning before and after temporal lobe epilepsy surgery. ( 28033547 )
2017
39
Exploring psychiatric comorbidities and their effects on quality of life in patients with temporal lobe epilepsy and juvenile myoclonic epilepsy. ( 28025856 )
2016
40
Naringenin ameliorates kainic acid-induced morphological alterations in the dentate gyrus in a mouse model of temporal lobe epilepsy. ( 27584687 )
2016
41
Brain Infiltration of Immune Cells in CASPR2-Antibody Associated Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. ( 28360810 )
2016
42
The impact of intelligence on memory and executive functions of children with temporal lobe epilepsy: Methodological concerns with clinical relevance. ( 28089585 )
2016
43
Epilepsy surgery in drug resistant temporal lobe epilepsy associated with neuronal antibodies. ( 28043058 )
2016
44
Increased expression of BDNF transcript with exon VI in hippocampi of patients with pharmaco-resistant temporal lobe epilepsy. ( 26621122 )
2016
45
In response: Brain atrophy in seizure-free temporal lobe epilepsy: Implications for predicting pharmacoresistance. ( 27160803 )
2016
46
Lithium therapy in comorbid temporal lobe epilepsy and cycloid psychosis. ( 28031853 )
2016
47
Combined (18)F-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 27995064 )
2016
48
Hippocampal atrophy on MRI is predictive of histopathological patterns and surgical prognosis in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 27842262 )
2016
49
1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy. ( 27208748 )
2016
50
Long-term outcome of mild mesial temporal lobe epilepsy: A prospective longitudinal cohort study. ( 27164663 )
2016

Variations for Temporal Lobe Epilepsy

Expression for Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for Temporal Lobe Epilepsy

Pathways related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.35 GABBR1 GABBR2 GRIK1 GRIN1 HTR1A NPY
2
Show member pathways
12.72 GABBR1 GABBR2 GAD1 GRIK1 GRIN1 SLC1A2
3 11.92 BDNF GRIN1 HTR1A SLC1A3
4 11.87 CALB1 GABBR1 GABBR2 GAD1 GFAP GRIN1
5 11.82 CALB1 HTR1A TSPO
6
Show member pathways
11.8 GABBR1 GABBR2 HTR1A
7
Show member pathways
11.77 BDNF GRIN1 PDYN
8 11.75 BDNF GFAP GRIN1 PDYN
9
Show member pathways
11.74 GRIN1 SLC1A2 SLC1A3
10
Show member pathways
11.74 BDNF GABBR1 GABBR2 GRIN1 HTR1A NPY
11 11.46 BDNF GAD1 GFAP SLC1A3
12 11.4 BDNF GAD1 GRIN1
13 10.7 GABBR1 GABBR2
14 10.56 GABBR1 GABBR2 GAD1
15
Show member pathways
10.36 SLC1A2 SLC1A3

GO Terms for Temporal Lobe Epilepsy

Cellular components related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 GABBR1 GABBR2 GRIK1 GRIN1 HTR1A SLC1A3
2 cell junction GO:0030054 9.85 GABBR1 GABBR2 GRIK1 GRIN1 LGI1 SV2B
3 neuron projection GO:0043005 9.78 CALB1 GABBR2 GRIN1 SLC1A3
4 axon GO:0030424 9.71 CALB1 GAD1 PVALB SLC1A2
5 postsynaptic membrane GO:0045211 9.62 GABBR1 GABBR2 GRIK1 GRIN1
6 dendrite GO:0030425 9.55 CALB1 GABBR1 GRIN1 PDYN RELN
7 terminal bouton GO:0043195 9.43 CALB1 GRIN1 PVALB
8 synapse GO:0045202 9.23 CALB1 GABBR1 GABBR2 GAD1 GRIK1 GRIN1
9 G-protein coupled receptor heterodimeric complex GO:0038039 8.96 GABBR1 GABBR2
10 plasma membrane GO:0005886 10.23 GABBR1 GABBR2 GAD1 GRIK1 GRIN1 HTR1A

Biological processes related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.87 GAD1 SLC1A2 SLC1A3 TSPO
2 ion transport GO:0006811 9.85 GRIK1 GRIN1 SCN1B SLC1A2 SLC1A3 TSPO
3 axon guidance GO:0007411 9.71 BDNF LGI1 RELN SCN1B
4 cerebral cortex development GO:0021987 9.63 GRIN1 NPY RELN
5 response to pain GO:0048265 9.56 RELN TSPO
6 positive regulation of synaptic transmission GO:0050806 9.55 LGI1 SLC1A3
7 L-glutamate transmembrane transport GO:0089711 9.54 SLC1A2 SLC1A3
8 behavior GO:0007610 9.52 HTR1A NPY
9 L-glutamate transport GO:0015813 9.49 SLC1A2 SLC1A3
10 response to wounding GO:0009611 9.48 SLC1A2 SLC1A3
11 regulation of behavior GO:0050795 9.43 HTR1A RELN
12 long-term memory GO:0007616 9.33 CALB1 GRIN1 RELN
13 D-aspartate import GO:0070779 9.26 SLC1A2 SLC1A3
14 chemical synaptic transmission GO:0007268 9.23 GABBR2 GAD1 GRIK1 NPY PDYN SCN1B
15 positive regulation of glial cell proliferation GO:0060252 9.21 TSPO
16 L-glutamate import across plasma membrane GO:0098712 9.02 SLC1A3
17 gamma-aminobutyric acid biosynthetic process GO:0009449 8.96 GAD1 SLC1A3

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular-glutamate-gated ion channel activity GO:0005234 9.4 GRIK1 GRIN1
2 ionotropic glutamate receptor activity GO:0004970 9.37 GRIK1 GRIN1
3 L-glutamate transmembrane transporter activity GO:0005313 9.32 SLC1A2 SLC1A3
4 high-affinity glutamate transmembrane transporter activity GO:0005314 9.26 SLC1A2 SLC1A3
5 G-protein coupled GABA receptor activity GO:0004965 9.16 GABBR1 GABBR2
6 glutamate:sodium symporter activity GO:0015501 8.96 SLC1A2 SLC1A3
7 glutamate binding GO:0016595 8.8 GAD1 GRIN1 SLC1A3

Sources for Temporal Lobe Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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