Aliases & Classifications for Temporal Lobe Epilepsy

MalaCards integrated aliases for Temporal Lobe Epilepsy:

Name: Temporal Lobe Epilepsy 37 12 14
Epilepsy, Temporal Lobe 12 41 69
Epilepsy Temporal Lobe 51

Classifications:



External Ids:

Disease Ontology 12 DOID:3328
MeSH 41 D004833
UMLS 69 C0014556

Summaries for Temporal Lobe Epilepsy

MalaCards based summary : Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to epilepsy, familial temporal lobe, 1 and autosomal dominant epilepsy with auditory features, and has symptoms including seizures An important gene associated with Temporal Lobe Epilepsy is RELN (Reelin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Transmission across Chemical Synapses. The drugs Citalopram and Amitriptyline have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and cortex, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 72 Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system characterized by recurrent,... more...

Related Diseases for Temporal Lobe Epilepsy

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 epilepsy, familial temporal lobe, 1 33.4 LGI1 RELN
2 autosomal dominant epilepsy with auditory features 32.7 LGI1 RELN
3 epilepsy 31.7 GABBR1 GAD1 LGI1 RELN SCN1B
4 encephalitis 30.8 GFAP LGI1 TSPO
5 dysembryoplastic neuroepithelial tumor 30.4 GFAP GRIN1
6 anxiety 30.4 BDNF HTR1A NPY TSPO
7 status epilepticus 30.3 BDNF CALB1 GFAP LGI1 NPY PVALB
8 mood disorder 30.3 BDNF HTR1A NPY
9 neuronal migration disorders 30.1 CALB1 PVALB RELN
10 major depressive disorder 30.1 BDNF GAD1 HTR1A NPY SLC1A2
11 epilepsy, idiopathic generalized 30.0 GABBR1 LGI1 SCN1B TSPO
12 psychotic disorder 29.5 BDNF HTR1A RELN SLC1A1
13 obsessive-compulsive disorder 29.3 BDNF HTR1A SLC1A1
14 alzheimer disease 29.3 BDNF GFAP GRIN1 RELN SLC1A2 SLC1A3
15 schizophrenia 26.3 BDNF CALB1 GABBR1 GAD1 GRIK1 GRIN1
16 mesial temporal lobe epilepsy with hippocampal sclerosis 12.4
17 benign familial mesial temporal lobe epilepsy 12.2
18 infantile-onset mesial temporal lobe epilepsy with severe cognitive regression 12.2
19 epilepsy, familial temporal lobe, 2 12.2
20 epilepsy, familial temporal lobe, 3 12.2
21 epilepsy, familial temporal lobe, 7 11.9
22 epilepsy, familial temporal lobe, 4 11.8
23 epilepsy, familial temporal lobe, 5 11.7
24 epilepsy, familial temporal lobe, 6 11.7
25 epilepsy, familial temporal lobe, 8 11.7
26 temporal epilepsy, familial 11.7
27 autosomal dominant partial epilepsy with auditory features 11.4
28 epilepsy, familial focal, with variable foci 2 11.2
29 epilepsy, familial focal, with variable foci 3 11.2
30 febrile seizures, familial, 11 11.2
31 lipoid proteinosis of urbach and wiethe 11.1
32 epilepsy, nocturnal frontal lobe, 1 11.1
33 mental retardation, anterior maxillary protrusion, and strabismus 11.1
34 neuronitis 10.6
35 dissociative amnesia 10.5 HTR1A PDYN
36 febrile seizures 10.4
37 breast fibrosarcoma 10.4 CALB1 PVALB
38 generalized anxiety disorder 10.4 BDNF HTR1A TSPO
39 childhood disintegrative disease 10.4 BDNF LGI1
40 toxic encephalopathy 10.3 BDNF GFAP SLC1A2
41 focal epilepsy 10.3 LGI1 PDYN TSPO
42 neonatal hypoxic and ischemic brain injury 10.3 BDNF PVALB SLC1A3
43 sensory neuropathy type 1 10.3 GABBR1 GABBR2
44 ocular dominance 10.3 BDNF GAD1 GRIN1
45 cerebritis 10.2
46 leukoencephalopathy, hereditary diffuse, with spheroids 10.2 GFAP SLC1A2
47 panic disorder 10.2 BDNF HTR1A TSPO
48 neuronal ceroid-lipofuscinoses 10.2 GFAP PVALB SLC1A3
49 spinal cord injury 10.2 BDNF GFAP GRIN1 PDYN
50 aging 10.2

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to Temporal Lobe Epilepsy

Symptoms & Phenotypes for Temporal Lobe Epilepsy

UMLS symptoms related to Temporal Lobe Epilepsy:


seizures

MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.46 GFAP CALB1 GRIK1 GABBR1 GRIN1 GABBR2
2 growth/size/body region MP:0005378 10.28 BDNF GFAP GRIK1 GABBR1 GRIN1 GABBR2
3 nervous system MP:0003631 10.23 BDNF GFAP CALB1 GRIK1 GABBR1 GRIN1
4 mortality/aging MP:0010768 10.2 BDNF GFAP GABBR1 GRIN1 GABBR2 HTR1A
5 homeostasis/metabolism MP:0005376 10.18 BDNF GFAP GABBR1 GRIN1 GABBR2 HTR1A
6 cellular MP:0005384 10.17 GAD1 BDNF GFAP GRIN1 SLC1A1 SLC1A2
7 no phenotypic analysis MP:0003012 9.76 BDNF GRIN1 HTR1A GAD1 PDYN PVALB
8 normal MP:0002873 9.73 BDNF GFAP CALB1 GRIK1 GRIN1 GAD1
9 vision/eye MP:0005391 9.28 BDNF GFAP GRIN1 SLC1A1 SLC1A3 RELN

Drugs & Therapeutics for Temporal Lobe Epilepsy

Drugs for Temporal Lobe Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4 59729-33-8 2771
2
Amitriptyline Approved Phase 4 50-48-6 2160
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Perphenazine Approved Phase 4 58-39-9 4748
5 Antidepressive Agents Phase 4
6 Antidepressive Agents, Second-Generation Phase 4
7 Antiparkinson Agents Phase 4
8 Autonomic Agents Phase 4
9 Cholinergic Agents Phase 4
10 Cholinergic Antagonists Phase 4
11 Muscarinic Antagonists Phase 4
12 Neurotransmitter Agents Phase 4,Phase 2
13 Neurotransmitter Uptake Inhibitors Phase 4
14 Parasympatholytics Phase 4
15 Peripheral Nervous System Agents Phase 4
16 Psychotropic Drugs Phase 4,Phase 2
17
Serotonin Phase 4,Phase 2 50-67-9 5202
18 Serotonin Agents Phase 4,Phase 2
19 Serotonin Uptake Inhibitors Phase 4
20 Anesthetics Phase 4,Phase 3
21 Adrenergic Agents Phase 4
22 Amitriptyline, perphenazine drug combination Phase 4
23 Analgesics Phase 4
24 Analgesics, Non-Narcotic Phase 4
25 Anesthetics, Local Phase 4
26 Anti-Arrhythmia Agents Phase 4
27 Antidepressive Agents, Tricyclic Phase 4
28 Antipsychotic Agents Phase 4
29 Central Nervous System Depressants Phase 4,Phase 2
30 Diuretics, Potassium Sparing Phase 4
31 Sodium Channel Blockers Phase 4
32 Tranquilizing Agents Phase 4,Phase 2
33
Menthol Approved Phase 3 2216-51-5 16666
34 Anticonvulsants Phase 3
35
Buspirone Approved, Investigational Phase 2 36505-84-7 2477
36 Anti-Anxiety Agents Phase 2
37 Naluzotan Phase 2
38 Serotonin 5-HT1 Receptor Agonists Phase 2
39
Sertraline Approved 79617-96-2 68617
40
Dopamine Approved 51-61-6, 62-31-7 681
41
Memantine Approved, Investigational 19982-08-2 4054
42
Glutamic Acid Approved, Nutraceutical 56-86-0 33032
43 Fluorides
44 Fluorodeoxyglucose F18
45 Dopamine Agents
46 Excitatory Amino Acid Antagonists
47 Excitatory Amino Acids
48 Krestin

Interventional clinical trials:

(show all 46)

# Name Status NCT ID Phase Drugs
1 Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy Completed NCT00595699 Phase 4 escitalopram;placebo
2 Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines Enrolling by invitation NCT02090998 Phase 4 Amitriptyline
3 Early Surgical Intervention to Treat Epilepsy Completed NCT00040326 Phase 3 antiepileptic drugs
4 Radiosurgery or Open Surgery for Epilepsy Trial Active, not recruiting NCT00860145 Phase 3
5 A Multicenter Study of Hippocampal Electrical Stimulation (HS, in Mesial Temporal Lobe Epilepsy Terminated NCT00717431 Phase 3
6 Buspirone Therapy for Localized Epilepsy Terminated NCT01496612 Phase 2 Buspirone
7 PRX-00023 Therapy in Localization-Related Epilepsy Terminated NCT01281956 Phase 2 PRX-00023
8 Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy Completed NCT00916266 Phase 1
9 Efficacy of TDCS for Treating Working Memory Dysfunction and Depression in Temporal Lobe Epilepsy Withdrawn NCT02268578 Phase 1
10 Low-intensity Focused Ultrasound Pulsation (LIFUP) for Treatment of Temporal Lobe Epilepsy Unknown status NCT02151175
11 Controlled Randomized Vagus Nerve Stimulation (VNS) Therapy Versus Resection (CoRaVNStiR) Unknown status NCT02089243
12 Application of Diffusion Tensor Imaging and Tractography in Epilepsy Surgery Unknown status NCT02590419
13 Controlled Randomized Stimulation Versus Resection (CoRaStiR) Unknown status NCT00431457
14 Emotional Processing and Memory Evaluation in Epilepsy Patients Unknown status NCT00486239 Early Phase 1
15 Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy Completed NCT01563627
16 Study of [11C]DPA-713 for Temporal Lobe Epilepsy Completed NCT01793532
17 CBT Versus Selective Serotonin Reuptake Inhibitor For Treatment Of Depression In Temporal Lobe Epilepsy Patients Completed NCT02262156 SSRI
18 Language and Emotional Function in Patients With Temporal Lobe Epilepsy Completed NCT00081432
19 GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression Completed NCT00931619
20 Electrical Brain Stimulation to Reduce Epileptic Seizures Completed NCT00344877
21 Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery Completed NCT03102957
22 Does Memantine Improve Verbal Memory Task Performance in Subjects With Partial Epilepsy and Memory Dysfunction? Completed NCT01054599 Memantine;Memantine
23 Neocortical Epilepsies - Do They Progress? Completed NCT00610558
24 Functional Link Between Hippocampal and Vestibular Systems: a Pilot Study in Epilepsy Surgery Completed NCT01285921
25 Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy Completed NCT00001672
26 Brain P-gp and Inflammation in People With Epilepsy Completed NCT01663545
27 Light Scattering Spectroscopy to Determine Brain Tumors Completed NCT00067418
28 fMRI Guided TMS Enhancement of Associative Memory Networks Completed NCT02749422
29 Arterial Spin Labeling MRI Focal Abnormalities in Refractory Epilepsy Completed NCT01772654
30 Language Mapping in Patients With Epilepsy Completed NCT00706160
31 Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE) Recruiting NCT02383407
32 Low Frequency TMS for Depression in Epilepsy Recruiting NCT03105700
33 Subcutaneous EEG in Epilepsy Recruiting NCT02946151
34 Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation Recruiting NCT02339376
35 Surgery as a Treatment for Medically Intractable Epilepsy Recruiting NCT01273129
36 Evaluation and Treatment of Patients With Epilepsy Recruiting NCT00013845
37 Brain Network Activation Analysis in Epilepsy Recruiting NCT03265925
38 Feasibility Study on LITT for Medical Refractory Epilepsy Active, not recruiting NCT02820740
39 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Active, not recruiting NCT02796287
40 COMETE Study : COgnitive Rehabilitation of MEmory in Temporal Epilepsy Not yet recruiting NCT02589470
41 Evaluation of Stress Sensitivity and Hyperemotivity in Epilepsy Compared to and a Group of Healthy Volunteers Not yet recruiting NCT03464370 Not Applicable
42 Near Death Experience (NDE) and Migraine Not yet recruiting NCT02854930
43 Emotion Recognition in Benign Epilepsy of Childhood With Centro-Temporal Spikes (BECTS) Not yet recruiting NCT03465566
44 Stereotactic Laser Ablation for Temporal Lobe Epilepsy Suspended NCT02844465
45 The Utility of NIOM During LITT for Refractory MTLE Withdrawn NCT02913742
46 Efficacy and Safety of the Use of Memantine for Preserving Cognition in Adult Patients With Epilepsy Withdrawn NCT00986115 Memantine;Placebo

Search NIH Clinical Center for Temporal Lobe Epilepsy

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: epilepsy, temporal lobe

Genetic Tests for Temporal Lobe Epilepsy

Anatomical Context for Temporal Lobe Epilepsy

MalaCards organs/tissues related to Temporal Lobe Epilepsy:

38
Temporal Lobe, Brain, Cortex, Bone, Amygdala, Bone Marrow, Testes

Publications for Temporal Lobe Epilepsy

Articles related to Temporal Lobe Epilepsy:

(show top 50) (show all 1038)
# Title Authors Year
1
Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder? ( 29414551 )
2018
2
SRR intronic variation inhibits expression of its neighbouring SMG6 gene and protects against temporal lobe epilepsy. ( 29363864 )
2018
3
The relationship between structural MRI, FDG-PET, and memory in temporal lobe epilepsy: Preliminary results. ( 29414560 )
2018
4
Stereotactic Laser Amygdalohippocampotomy for Mesial Temporal Lobe Epilepsy. ( 29420840 )
2018
5
Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 29247965 )
2018
6
High-Throughput Data of Circular RNA Profiles in Human Temporal Cortex Tissue Reveals Novel Insights into Temporal Lobe Epilepsy. ( 29428937 )
2018
7
Impaired spatial pattern separation performance in temporal lobe epilepsy is associated with visuospatial memory deficits and hippocampal volume loss. ( 29428769 )
2018
8
SPECT perfusion changes during ictal automatisms with preserved responsiveness in patients with right temporal lobe epilepsy. ( 29396356 )
2018
9
Alterations of theta oscillation in executive control in temporal lobe epilepsy patients. ( 29358157 )
2018
10
Laser ablation is effective for temporal lobe epilepsy with and without mesial temporal sclerosis if hippocampal seizure onsets are localized by stereoelectroencephalography. ( 29392715 )
2018
11
Follow-Up of Peripheral IL-1I^ and IL-6 and Relation with Apoptotic Death in Drug-Resistant Temporal Lobe Epilepsy Patients Submitted to Surgery. ( 29401729 )
2018
12
Long-Term Electroclinical and Employment Follow up in Temporal Lobe Epilepsy Surgery. A Cuban Comprehensive Epilepsy Surgery Program. ( 29389846 )
2018
13
Altered spontaneous brain activity in MRI-negative refractory temporal lobe epilepsy patients with major depressive disorder: A resting-state fMRI study. ( 29406962 )
2018
14
[<sup>18</sup>F]GE180 positron emission tomographic imaging indicates a potential double-hit insult in the intrahippocampal kainate mouse model of temporal lobe epilepsy. ( 29364511 )
2018
15
Unique and shared areas of cognitive function in children with intractable frontal or temporal lobe epilepsy. ( 29414546 )
2018
16
Surgical Management and Long-Term Seizure Outcome After Surgery for Temporal Lobe Epilepsy Associated with Cerebral Cavernous Malformations. ( 29175574 )
2018
17
Echocardiographic risk markers of sudden death in patients with temporal lobe epilepsy. ( 29414527 )
2018
18
Topographic principles of cortical fluid-attenuated inversion recovery signal in temporal lobe epilepsy. ( 29383717 )
2018
19
Intracranial electrodes monitoring improves seizure control and complication outcomes for patients with temporal lobe epilepsy - A retrospective cohort study. ( 29360612 )
2018
20
Comparing CAT12 and VBM8 for Detecting Brain Morphological Abnormalities in Temporal Lobe Epilepsy. ( 28883807 )
2017
21
Decline in word-finding: The objective cognitive finding most relevant to patients after mesial temporal lobe epilepsy surgery. ( 28867574 )
2017
22
Lack of heart rate variability during sleep-related apnea in patients with temporal lobe epilepsy (TLE)-an indirect marker of SUDEP? ( 28091857 )
2017
23
Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy. ( 28912503 )
2017
24
Psychogenic nonepileptic seizures in patients with surgically treated temporal lobe epilepsy: Presurgical and de novo postsurgical occurrence. ( 28867568 )
2017
25
Deep brain stimulation for refractory temporal lobe epilepsy: a systematic review and meta-analysis with an emphasis on alleviation of seizure frequency outcome. ( 28921161 )
2017
26
Hamartia in hippocampal sclerosis-associated mesial temporal lobe epilepsy. ( 28888331 )
2017
27
A Prediction Algorithm for Drug Response in Patients with Mesial Temporal Lobe Epilepsy Based on Clinical and Genetic Information. ( 28052106 )
2017
28
Pharmacoresistance with newer anti-epileptic drugs in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 28941835 )
2017
29
Bilateral cingulum fiber reductions in temporal lobe epilepsy with unilateral hippocampal sclerosis. ( 28941760 )
2017
30
TRIF contributes to epileptogenesis in temporal lobe epilepsy during TLR4 activation. ( 28867282 )
2017
31
Personalized structural image analysis in patients with temporal lobe epilepsy. ( 28883420 )
2017
32
NTRK2 (TrkB gene) variants and temporal lobe epilepsy: A genetic association study. ( 28863320 )
2017
33
Hippocampal Atrophy Is Associated with Altered Hippocampus-Posterior Cingulate Cortex Connectivity in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. ( 28104639 )
2017
34
Smad anchor for receptor activation contributes to seizures in temporal lobe epilepsy. ( 28035691 )
2017
35
Severe intermittent anxiety attacks. A diagnosis challenge in temporal lobe epilepsy. ( 28064331 )
2017
36
Preoperative automated fibre quantification predicts postoperative seizure outcome in temporal lobe epilepsy. ( 28031219 )
2017
37
Pro-excitatory alterations in sodium channel activity facilitate subiculum neuron hyperexcitability in temporal lobe epilepsy. ( 28860087 )
2017
38
Volumetric Changes in Hippocampal Subregions and Memory Performance in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. ( 29094314 )
2017
39
Altered functional connectivity in mesial temporal lobe epilepsy. ( 28923408 )
2017
40
Visual Deficit From Laser Interstitial Thermal Therapy for Temporal Lobe Epilepsy: Anatomical Considerations. ( 28922876 )
2017
41
Quantitative and qualitative analysis of semantic verbal fluency in patients with temporal lobe epilepsy. ( 28863828 )
2017
42
Impact of hippocampal subfield histopathology in episodic memory impairment in mesial temporal lobe epilepsy and hippocampal sclerosis. ( 28873362 )
2017
43
An epileptologist's view: Seizure-related outcomes after radiofrequency ablation for mesial temporal lobe epilepsy. ( 28927701 )
2017
44
Relationship between neuronal network architecture and naming performance in temporal lobe epilepsy: A connectome based approach using machine learning. ( 28899551 )
2017
45
The role of presurgical EEG parameters and of reoperation for seizure outcome in temporal lobe epilepsy. ( 28888215 )
2017
46
Navigation-assisted trans-inferotemporal cortex selective amygdalohippocampectomy for mesial temporal lobe epilepsy; preserving the temporal stem. ( 28067149 )
2017
47
Disconnection of hippocampal networks contributes to memory dysfunction in individuals with temporal lobe epilepsy. ( 28888031 )
2017
48
Genome-Wide DNA Methylation Patterns Analysis of Noncoding RNAs in Temporal Lobe Epilepsy Patients. ( 28058582 )
2017
49
MicroRNA and mesial temporal lobe epilepsy with hippocampal sclerosis: Whole miRNome profiling of human hippocampus. ( 28815576 )
2017
50
Rabies Tracing of Birthdated Dentate Granule Cells in Rat Temporal Lobe Epilepsy. ( 28470680 )
2017

Variations for Temporal Lobe Epilepsy

Expression for Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for Temporal Lobe Epilepsy

Pathways related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.39 GABBR1 GABBR2 GRIK1 GRIN1 HTR1A NPY
2
Show member pathways
12.61 GABBR1 GABBR2 GAD1 GRIK1 GRIN1 SLC1A1
3
Show member pathways
12.58 GRIK1 GRIN1 SLC1A1 SLC1A2 SLC1A3
4
Show member pathways
11.99 GAD1 SLC1A1 SLC1A2 SLC1A3
5 11.95 BDNF GRIN1 HTR1A SLC1A3
6 11.93 CALB1 GABBR1 GABBR2 GAD1 GFAP GRIN1
7 11.85 CALB1 HTR1A TSPO
8
Show member pathways
11.82 GABBR1 GABBR2 HTR1A
9
Show member pathways
11.79 BDNF GRIN1 PDYN
10 11.78 BDNF GFAP GRIN1 PDYN
11
Show member pathways
11.74 BDNF GABBR1 GABBR2 GRIN1 HTR1A NPY
12
Show member pathways
11.73 GRIN1 SLC1A1 SLC1A2 SLC1A3
13 11.52 BDNF GAD1 GFAP SLC1A3
14 11.45 BDNF GAD1 GRIN1
15 10.74 GABBR1 GABBR2
16 10.66 GABBR1 GABBR2 GAD1
17
Show member pathways
10.4 SLC1A2 SLC1A3

GO Terms for Temporal Lobe Epilepsy

Cellular components related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.91 GABBR1 GABBR2 GRIK1 GRIN1 LGI1 SV2B
2 neuron projection GO:0043005 9.78 CALB1 GABBR2 GRIN1 SLC1A3
3 axon GO:0030424 9.76 CALB1 GAD1 PVALB SLC1A2
4 integral component of plasma membrane GO:0005887 9.76 GABBR1 GABBR2 GRIK1 GRIN1 HTR1A SLC1A1
5 postsynaptic membrane GO:0045211 9.71 GABBR1 GABBR2 GRIK1 GRIN1
6 dendrite GO:0030425 9.65 CALB1 GABBR1 GRIN1 PDYN RELN
7 terminal bouton GO:0043195 9.54 CALB1 GRIN1 PVALB
8 synapse GO:0045202 9.23 CALB1 GABBR1 GABBR2 GAD1 GRIK1 GRIN1
9 G-protein coupled receptor heterodimeric complex GO:0038039 8.96 GABBR1 GABBR2
10 plasma membrane GO:0005886 10.13 GABBR1 GABBR2 GAD1 GRIK1 GRIN1 HTR1A

Biological processes related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.91 GAD1 SLC1A2 SLC1A3 TSPO
2 ion transport GO:0006811 9.91 GRIK1 GRIN1 SCN1B SLC1A1 SLC1A2 SLC1A3
3 axon guidance GO:0007411 9.84 BDNF LGI1 RELN SCN1B
4 response to wounding GO:0009611 9.74 GFAP SLC1A2 SLC1A3
5 cerebral cortex development GO:0021987 9.73 GRIN1 NPY RELN
6 amino acid transport GO:0006865 9.7 SLC1A1 SLC1A2 SLC1A3
7 long-term memory GO:0007616 9.69 CALB1 GRIN1 RELN
8 glutamate secretion GO:0014047 9.63 SLC1A1 SLC1A2 SLC1A3
9 response to pain GO:0048265 9.61 RELN TSPO
10 positive regulation of synaptic transmission GO:0050806 9.6 LGI1 SLC1A3
11 positive regulation of glial cell proliferation GO:0060252 9.58 GFAP TSPO
12 behavior GO:0007610 9.58 HTR1A NPY
13 regulation of behavior GO:0050795 9.55 HTR1A RELN
14 L-glutamate transmembrane transport GO:0089711 9.5 SLC1A1 SLC1A2 SLC1A3
15 gamma-aminobutyric acid biosynthetic process GO:0009449 9.49 GAD1 SLC1A3
16 L-glutamate import GO:0051938 9.48 SLC1A1 SLC1A3
17 D-aspartate import across plasma membrane GO:0140016 9.43 SLC1A1 SLC1A3
18 L-glutamate transport GO:0015813 9.43 SLC1A1 SLC1A2 SLC1A3
19 L-aspartate import across plasma membrane GO:0140009 9.4 SLC1A1 SLC1A3
20 L-glutamate import across plasma membrane GO:0098712 9.33 SLC1A1 SLC1A2 SLC1A3
21 chemical synaptic transmission GO:0007268 9.32 GABBR2 GAD1 GRIK1 NPY PDYN SCN1B
22 D-aspartate import GO:0070779 9.13 SLC1A1 SLC1A2 SLC1A3
23 transport GO:0006810 10.19 GRIK1 GRIN1 SCN1B SLC1A1 SLC1A2 SLC1A3

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 symporter activity GO:0015293 9.63 SLC1A1 SLC1A2 SLC1A3
2 amino acid transmembrane transporter activity GO:0015171 9.54 SLC1A1 SLC1A2 SLC1A3
3 extracellularly glutamate-gated ion channel activity GO:0005234 9.43 GRIK1 GRIN1
4 L-glutamate transmembrane transporter activity GO:0005313 9.43 SLC1A1 SLC1A2 SLC1A3
5 ionotropic glutamate receptor activity GO:0004970 9.4 GRIK1 GRIN1
6 high-affinity glutamate transmembrane transporter activity GO:0005314 9.33 SLC1A1 SLC1A2 SLC1A3
7 G-protein coupled GABA receptor activity GO:0004965 9.32 GABBR1 GABBR2
8 glutamate:sodium symporter activity GO:0015501 9.13 SLC1A1 SLC1A2 SLC1A3
9 glutamate binding GO:0016595 8.92 GAD1 GRIN1 SLC1A1 SLC1A3

Sources for Temporal Lobe Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....