MCID: TND004
MIFTS: 48

Tendinopathy malady

Summaries for Tendinopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Tendinopathy refers to a disease of a tendon. More specifically, it can refer to: more...

MalaCards: Tendinopathy is related to tendinitis and obesity. An important gene associated with Tendinopathy is MIR608 (microRNA 608), and among its related pathways are Degradation of collagen and Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction). The compounds estrogen and procollagen have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and spinal cord, and related mouse phenotypes are limbs/digits/tail and normal.

Aliases & Classifications for Tendinopathy

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32MalaCards, 30LifeMap Discovery™, 60UMLS
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Aliases & Descriptions:

tendinopathy 32 30 60


Related Diseases for Tendinopathy

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17GeneCards, 18GeneDecks
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Diseases related to Tendinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1tendinitis30.1TNC, COMP
2obesity30.1COMP, NPY, MMP3, NOS3
3pseudoachondroplasia29.9COMP
4multiple epiphyseal dysplasia29.9ACAN, COMP
5diabetes mellitus29.9NOS3, MMP3, IL1R1, NPY
6tendinosis10.3
7neuronitis10.2
8epicondylitis10.2
9achilles bursitis10.1
10bursitis10.1
11enthesopathy10.1
12peritonitis10.0MMP8
13bipolar disorder10.0GRIN1
14down syndrome10.0CHAT
15cerebral palsy10.0MMP8
16spondylitis10.0ACAN
17pneumonia10.0MMP8
18dermatofibrosarcoma protuberans10.0ACTC1
19oral submucous fibrosis10.0MMP1
20migraine10.0CHRM2
21sarcoidosis10.0DCN
22gingivitis10.0MMP1, MMP8
23primary hyperoxaluria10.0NOS3
24hepatitis c10.0IL1R1
25leiomyoma10.0MMP3, ACTC1
26acute myocardial infarction10.0MMP8, TNC
27chorioamnionitis10.0MMP8, IL1R1
28ovarian cancer10.0DCN
29myopia 610.0DCN, FMOD
30thyroid cancer10.0TNC
31dementia10.0CHAT, MMP3
32pulmonary emphysema10.0MMP8, MMP1
33aggressive periodontitis10.0MMP1, MMP8
34hepatocellular carcinoma10.0DCN
35epidermolysis bullosa dystrophica10.0MMP3, MMP1
36neuroblastoma10.0CHAT
37diabetic retinopathy10.0NOS3
38amyotrophic lateral sclerosis10.0CHAT, SLC18A3
39ehlers-danlos syndrome10.0DCN, COL5A1
40localized scleroderma10.0DCN, MMP1
41hypertension10.0NOS3, NPY
42dilated cardiomyopathy10.0CHRM2, MMP1, ACTC1
43neurofibroma10.0ACTC1, TNC
44psoriatic arthritis10.0COMP, MMP3, MMP1
45psoriasis10.0NOS3, IL1R1
46osteochondritis dissecans10.0ACAN
47tongue cancer10.0TNC, MMP8
48liver cirrhosis10.0NPY, NOS3
49gingival overgrowth10.0DCN, MMP3, MMP1
50pulmonary fibrosis10.0MMP1, DCN, TNC

Graphical network of the top 20 diseases related to Tendinopathy:



Diseases related to tendinopathy

Clinical Features for Tendinopathy

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Drugs & Therapeutics for Tendinopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Tendinopathy

Drug clinical trials:

Search ClinicalTrials for Tendinopathy

Search NIH Clinical Center for Tendinopathy

Search CenterWatch for Tendinopathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Tendinopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Tendinopathy:
Autologous tenocyte implantation for damaged tendons
Embryonic/Adult Cultured Cells Related to Tendinopathy:
Tenocytes, PMIDs: 24068695, 23314880

Genetic Tests for Tendinopathy

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Anatomical Context for Tendinopathy

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32MalaCards
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MalaCards organs/tissues related to Tendinopathy:

32
Bone, Testes, Spinal cord, Bone marrow, Whole blood, Endothelial

Animal Models for Tendinopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tendinopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.4VCAN, ACAN, FMOD, COL27A1, COMP
2MP:00028738.8COMP, TNC, NPY, CHAT, GRIN1, NOS3
3MP:00053888.6COL27A1, DCN, CHRM2, GRIN1, IL1R1, NOS3
4MP:00053858.6COL5A1, FMOD, CHAT, CHRM2, GRIN1, IL1R1
5MP:00053698.5CHAT, DCN, FMOD, COMP, CHRM2, IL1R1
6MP:00036318.2TNC, NPY, CHAT, CHRM2, GRIN1, IL1R1
7MP:00053768.1CHRM2, CHAT, DCN, NPY, TNC, GRIN1
8MP:00053868.1DCN, NPY, TNC, FMOD, COMP, CHAT
9MP:00053788.1DCN, NPY, FMOD, COL27A1, COMP, CHAT
10MP:00053908.1VCAN, COMP, COL27A1, FMOD, NPY, DCN

Publications for Tendinopathy

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50PubMed
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Articles related to Tendinopathy:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
MMP-8 polymorphism is genetic marker to tendinopathy primary posterior tibial tendon. (22487237)
2014
2
Beneficial effects of autologous bone marrow-derived mesenchymal stem cells in naturally occurring tendinopathy. (24086616)
2013
3
Tendinopathy a89 from basic science to treatment. (24003459)
2013
4
Tendinopathy: a review of the pathophysiology and evidence for treatment. (24113701)
2013
5
Differences in tendon properties in elite badminton players with or without patellar tendinopathy. (23227947)
2013
6
Science in brief: the likely role of the central nervous system in bilateral tendinopathy and tendon healing. (23738878)
2013
7
Neovascularity in patellar tendinopathy and the response to eccentric training: a case report using Power Doppler ultrasound. (23022320)
2013
8
Achilles tendinopathy after treatment with ophthalmic moxifloxacin. (23280174)
2013
9
Patients with rotator cuff tendinopathy can successfully self-manage, but with certain caveats: a qualitative study. (24238700)
2013
10
Capacity for sliding between tendon fascicles decreases with ageing in injury prone equine tendons: a possible mechanism for age-related tendinopathy? (23300032)
2013
11
Acromiohumeral distance measurement in rotator cuff tendinopathy: is there a reliable, clinically applicable method? A systematic review. (23821657)
2013
12
The risks and benefits of glucocorticoid treatment for tendinopathy: A systematic review of the effects of local glucocorticoid on tendon. (24074644)
2013
13
CHELT therapy in the treatment of chronic insertional Achilles tendinopathy. (24352875)
2013
14
Biomechanical properties of double- and single-row suture anchor repair for surgical treatment of insertional Achilles tendinopathy. (23644147)
2013
15
Proximal disinsertion of the common extensor tendon for lateral elbow tendinopathy. (23629999)
2013
16
Treatment for insertional Achilles tendinopathy: a systematic review. (23052113)
2013
17
Evaluation of a diode laser for use in induction of tendinopathy in the superficial digital flexor tendon of horses. (22924726)
2012
18
Evaluation and management of elbow tendinopathy. (23016111)
2012
19
Levofloxacin-induced tendinopathy of the hip. (22535840)
2012
20
Local biochemical and morphological differences in human Achilles tendinopathy: a case control study. (22480275)
2012
21
The surgical treatment of peroneal tendinopathy (excluding subluxations): a series of 17 patients. (22112304)
2012
22
Reconstructive surgery using autologous bone-patellar tendon graft for insertional Achilles tendinopathy. (22105979)
2012
23
Exercise for rotator cuff tendinopathy: a systematic review. (22507359)
2012
24
Analysis of hereditary and medical risk factors in Achilles tendinopathy and Achilles tendon ruptures: a matched pair analysis. (22350054)
2012
25
Tendinopathy: present challenges and perspectives for progression. (21223378)
2011
26
High hamstring tendinopathy in 3 female long distance runners. (22014863)
2011
27
Cross-cultural adaptation and validation of the VISA-P questionnaire for German-speaking patients with patellar tendinopathy. (21289458)
2011
28
Fluoroquinolone-associated tendinopathy. (22035890)
2011
29
Chronic Achilles tendinopathy treated with eccentric stretching program. (22097158)
2011
30
Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model. (21540192)
2011
31
Association of MMP-8 polymorphisms with tendinopathy of the primary posterior tibial tendon: a pilot study. (22179173)
2011
32
The pathogenesis of tendinopathy: balancing the response to loading. (20308995)
2010
33
Patient guided Piezo-electric Extracorporeal Shockwave Therapy as treatment for chronic severe patellar tendinopathy: A pilot study. (20858940)
2010
34
Mechanobiological response of tendon stem cells: implications of tendon homeostasis and pathogenesis of tendinopathy. (19918904)
2010
35
In vitro model to study chondrogenic differentiation in tendinopathy. (19279223)
2009
36
Cross-cultural adaptation and validation of the VISA-A questionnaire for German-speaking achilles tendinopathy patients. (19878572)
2009
37
Current concepts review: noninsertional Achilles tendinopathy. (19912730)
2009
38
Shock-wave treatment was more effective than eccentric training for chronic insertional achilles tendinopathy. (19451774)
2009
39
"Tenomalacia": a new sonographic sign of tendinopathy? (18677489)
2009
40
Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations. (18443036)
2009
41
Achilles tendinopathy: pathology and management strategies. (19749642)
2009
42
Does the dosage matter in sclerosing polidocanol injections in Achilles tendinopathy? (19099292)
2009
43
Management of tendinopathy. (19188560)
2009
44
VISA-P score for patellar tendinopathy in males: adaptation to Italian. (18720116)
2008
45
Molecular and clinical developments in tendinopathy: editorial comment. (18459029)
2008
46
A systematic review with procedural assessments and meta-analysis of low level laser therapy in lateral elbow tendinopathy (tennis elbow). (18510742)
2008
47
Italian translation of the VISA-A score for tendinopathy of the main body of the Achilles tendon. (18608373)
2008
48
VEGF expression in patellar tendinopathy: a preliminary study. (18459027)
2008
49
Eccentric training programmes in the management of lateral elbow tendinopathy. (18608381)
2008
50
Evidence-based soft tissue rheumatology: epicondylitis and hand stenosing tendinopathy. (17043459)
2004

Genetic Variations for Tendinopathy

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Expression for genes affiliated with Tendinopathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tendinopathy

Search GEO for disease gene expression data for Tendinopathy.

Pathways for genes affiliated with Tendinopathy

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Sources:
53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 52R&D Systems, 12EMD Millipore
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Pathways related to Tendinopathy according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1MMP3, COL5A1
210.0SLC18A3, CHAT
3
Hide members
10.0MMP8, MMP3, COL5A1
4
Hide members
10.0MMP3, MMP8, MMP1
5
Hide members
9.9COL27A1, COL5A1, COMP
69.8IL1R1, COL27A1, COL5A1
79.8NOS3, MMP1, DCN
89.8GRIN1, IL1R1, ACAN, VCAN
9
Hide members
9.7COMP, COL5A1, COL27A1, TNC
10
Hide members
9.6FMOD, DCN, ACAN, VCAN
119.6COMP, FMOD, DCN, ACAN
12
Cell adhesion Cell-matrix glycoconjugates
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9.6TNC, MMP3, MMP1, ACAN, VCAN
13
Hide members
9.4FMOD, TNC, DCN, ACAN, VCAN
14
Hide members
9.3COL5A1, COL27A1, TNC, MMP3, MMP8, MMP1
159.2COMP, COL5A1, COL27A1, TNC, CHRM2, NOS3
16
Cell adhesion ECM remodeling
Hide members
9.1FMOD, TNC, MMP3, MMP8, MMP1, ACAN
17
Hide members
8.3VCAN, COMP, COL5A1, COL27A1, FMOD, TNC

Compounds for genes affiliated with Tendinopathy

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Tendinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CHAT
2procollagen4410.5ACAN, FMOD
3(4-aminophenyl)mercuric acetate4410.4MMP3, MMP8
4leflunomide49 44 1112.1MMP1, MMP3, IL1R1, COMP
5neurocan4410.1TNC, DCN, ACAN, VCAN
6etanercept44 49 1112.1MMP1, MMP3, IL1R1, COMP
7dermatan44 2411.1DCN, ACAN, VCAN
8glutamate4410.1NPY, CHAT, GRIN1, SLC18A3
9dexamethasone44 49 28 1113.1DCN, CHAT, IL1R1, ACAN
10infliximab44 49 1112.0COMP, IL1R1, MMP3, MMP1
11alginate4410.0COMP, DCN, MMP3, ACAN, VCAN
12gi 254023x5910.0MMP1, MMP8, MMP3
13acetylcholine44 49 28 11 2413.9CHAT, CHRM2, MMP3, SLC18A3
14adalimumab44 49 1111.9MMP3, IL1R1, COMP
15dermatan sulfate449.9COMP, FMOD, DCN, ACAN, VCAN
16chondroitin44 2410.9FMOD, DCN, MMP3, ACAN, VCAN
17prednisolone44 28 1111.9COMP, NPY, IL1R1, MMP3, MMP1
18matrigel449.8DCN, MMP3, MMP1, NOS3, ACTC1
19formaldehyde44 2410.8TNC, NPY, CHAT, MMP1, ACTC1
20nicotine44 49 28 1112.8MMP1, GRIN1, CHRM2, CHAT, NPY
21cocaine44 1110.8NPY, CHAT, CHRM2, GRIN1, SLC18A3
22keratan sulfate449.7COMP, FMOD, DCN, MMP3, ACAN, VCAN
23ribonucleic acid449.7DCN, GRIN1, IL1R1, MMP3, MMP1, ACTC1
24methotrexate44 49 1111.7COMP, IL1R1, MMP3, MMP1, NOS3
25gm 6001599.7MMP1, MMP8, MMP3
26norepinephrine44 11 2411.6NPY, CHAT, CHRM2, GRIN1, IL1R1, MMP1
27choline44 11 2411.6NOS3, SLC18A3, CHRM2, CHAT, NPY
28heparin44 28 11 2412.6DCN, IL1R1, MMP3, VCAN
29ascorbic acid44 2410.6TNC, IL1R1, MMP3, MMP1, NOS3, ACAN
30tgf beta1449.6COMP, TNC, DCN, MMP3, MMP1, ACAN
31gaba449.6GRIN1, CHRM2, CHAT, NPY, TNC
32cyclosporin a44 28 5911.6ACTC1, MMP1, MMP8, MMP3, IL1R1, DCN
33lactate449.6COMP, NPY, CHAT, IL1R1, MMP3, MMP8
34pd 98,059449.6DCN, CHAT, MMP3, MMP1, NOS3, ACAN
35pge2449.5ACAN, MMP1, MMP8, MMP3, IL1R1, DCN
36chondroitin sulfate44 2410.5COMP, FMOD, TNC, DCN, MMP3, ACAN
37progesterone44 59 28 11 2413.5TNC, CHAT, IL1R1, MMP3, MMP8, MMP1
38creatinine449.3COMP, TNC, NPY, DCN, IL1R1, MMP3
39paraffin449.3TNC, NPY, DCN, CHAT, IL1R1, MMP3
40oligonucleotide449.3COMP, TNC, DCN, CHAT, GRIN1, IL1R1
41zinc44 2410.2DCN, CHRM2, GRIN1, IL1R1, MMP3, MMP8
42glucose449.2COMP, NPY, DCN, CHAT, IL1R1, MMP3
43vegf449.1TNC, DCN, IL1R1, MMP3, MMP8, MMP1
44hyaluronic acid44 2410.1FMOD, COMP, TNC, DCN, IL1R1, MMP3
45cysteine449.1COMP, TNC, DCN, GRIN1, IL1R1, MMP3
46glycosaminoglycan449.0VCAN, ACAN, ACTC1, MMP1, MMP8, MMP3
47nitric oxide44 11 2410.8NPY, DCN, CHAT, CHRM2, GRIN1, IL1R1
48calcium44 49 11 2411.6CHRM2, CHAT, NPY, TNC, COMP, GRIN1
49tyrosine448.5FMOD, TNC, NPY, DCN, CHAT, CHRM2
50retinoic acid44 249.1ACAN, COMP, TNC, NPY, ACTC1, NOS3

GO Terms for genes affiliated with Tendinopathy

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16Gene Ontology
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Cellular components related to Tendinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.6DCN, ACAN, VCAN, FMOD
2lysosomal lumenGO:0432029.3DCN, VCAN, ACAN, FMOD
3proteinaceous extracellular matrixGO:0055789.2COMP, ACAN, MMP1, MMP8, MMP3, FMOD
4extracellular matrixGO:0310129.2VCAN, ACAN, DCN, TNC, FMOD, COMP
5extracellular spaceGO:0056158.8VCAN, MMP8, COMP, FMOD, TNC, NPY
6extracellular regionGO:0055768.0VCAN, COMP, COL5A1, COL27A1, FMOD, TNC

Biological processes related to Tendinopathy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1chondroitin sulfate catabolic processGO:03020710.1VCAN, DCN
2dermatan sulfate biosynthetic processGO:03020810.0VCAN, DCN
3collagen catabolic processGO:03057410.0COL5A1, MMP3, MMP8, MMP1
4extracellular matrix disassemblyGO:0226179.9COL5A1, MMP3, MMP8, MMP1
5keratan sulfate catabolic processGO:0423409.7ACAN, FMOD
6glycosaminoglycan metabolic processGO:0302039.7VCAN, ACAN, DCN, FMOD
7cell adhesionGO:0071559.6COMP, COL5A1, TNC, ACAN, VCAN
8extracellular matrix organizationGO:0301988.5VCAN, COMP, COL5A1, COL27A1, FMOD, TNC

Molecular functions related to Tendinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422210.0MMP1, MMP8, MMP3
2extracellular matrix structural constituentGO:0052019.6ACAN, COL27A1, COL5A1, COMP
3calcium ion bindingGO:0055099.2COMP, GRIN1, MMP3, MMP8, MMP1, VCAN

Products for genes affiliated with Tendinopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tendinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet