MCID: TND004
MIFTS: 48

Tendinopathy malady

Summaries for Tendinopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Tendinopathy refers to a disease of a tendon. More specifically, it can refer to: more...

MalaCards: Tendinopathy is related to tendinitis and obesity. An important gene associated with Tendinopathy is MIR608 (microRNA 608), and among its related pathways are Degradation of collagen and Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction). The compounds estrogen and procollagen have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and bone marrow, and related mouse phenotypes are limbs/digits/tail and normal.

Aliases & Classifications for Tendinopathy

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32MalaCards, 30LifeMap Discovery™, 60UMLS
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Aliases & Descriptions:

tendinopathy 32 30 60


Related Diseases for Tendinopathy

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17GeneCards, 18GeneDecks
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Diseases related to Tendinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1tendinitis30.1TNC, COMP
2obesity30.1COMP, NPY, MMP3, NOS3
3pseudoachondroplasia29.9COMP
4multiple epiphyseal dysplasia29.9ACAN, COMP
5diabetes mellitus29.9NOS3, MMP3, IL1R1, NPY
6tendinosis10.3
7neuronitis10.2
8epicondylitis10.2
9achilles bursitis10.1
10bursitis10.1
11enthesopathy10.1
12peritonitis10.0MMP8
13bipolar disorder10.0GRIN1
14down syndrome10.0CHAT
15cerebral palsy10.0MMP8
16spondylitis10.0ACAN
17pneumonia10.0MMP8
18dermatofibrosarcoma protuberans10.0ACTC1
19oral submucous fibrosis10.0MMP1
20migraine10.0CHRM2
21sarcoidosis10.0DCN
22gingivitis10.0MMP1, MMP8
23primary hyperoxaluria10.0NOS3
24hepatitis c10.0IL1R1
25leiomyoma10.0MMP3, ACTC1
26acute myocardial infarction10.0MMP8, TNC
27chorioamnionitis10.0MMP8, IL1R1
28ovarian cancer10.0DCN
29myopia 610.0DCN, FMOD
30thyroid cancer10.0TNC
31dementia10.0CHAT, MMP3
32pulmonary emphysema10.0MMP8, MMP1
33aggressive periodontitis10.0MMP1, MMP8
34hepatocellular carcinoma10.0DCN
35epidermolysis bullosa dystrophica10.0MMP3, MMP1
36neuroblastoma10.0CHAT
37diabetic retinopathy10.0NOS3
38amyotrophic lateral sclerosis10.0CHAT, SLC18A3
39ehlers-danlos syndrome10.0DCN, COL5A1
40localized scleroderma10.0DCN, MMP1
41hypertension10.0NOS3, NPY
42dilated cardiomyopathy10.0CHRM2, MMP1, ACTC1
43neurofibroma10.0ACTC1, TNC
44psoriatic arthritis10.0COMP, MMP3, MMP1
45psoriasis10.0NOS3, IL1R1
46osteochondritis dissecans10.0ACAN
47tongue cancer10.0TNC, MMP8
48liver cirrhosis10.0NPY, NOS3
49gingival overgrowth10.0DCN, MMP3, MMP1
50pulmonary fibrosis10.0MMP1, DCN, TNC

Graphical network of the top 20 diseases related to Tendinopathy:



Diseases related to tendinopathy

Clinical Features for Tendinopathy

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Drugs & Therapeutics for Tendinopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Tendinopathy

Drug clinical trials:

Search ClinicalTrials for Tendinopathy

Search NIH Clinical Center for Tendinopathy

Search CenterWatch for Tendinopathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Tendinopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Tendinopathy:
Autologous tenocyte implantation for damaged tendons
Embryonic/Adult Cultured Cells Related to Tendinopathy:
Tenocytes, PMIDs: 24068695, 23314880

Genetic Tests for Tendinopathy

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Anatomical Context for Tendinopathy

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32MalaCards
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MalaCards organs/tissues related to Tendinopathy:

32
Bone, Testes, Bone marrow, Whole blood, Spinal cord, Endothelial

Animal Models for Tendinopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tendinopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.4VCAN, ACAN, FMOD, COL27A1, COMP
2MP:00028738.8COMP, TNC, NPY, CHAT, GRIN1, NOS3
3MP:00053888.6COL27A1, DCN, CHRM2, GRIN1, IL1R1, NOS3
4MP:00053858.6COL5A1, FMOD, CHAT, CHRM2, GRIN1, IL1R1
5MP:00053698.5CHAT, DCN, FMOD, COMP, CHRM2, IL1R1
6MP:00036318.2TNC, NPY, CHAT, CHRM2, GRIN1, IL1R1
7MP:00053768.1CHRM2, CHAT, DCN, NPY, TNC, GRIN1
8MP:00053868.1DCN, NPY, TNC, FMOD, COMP, CHAT
9MP:00053788.1DCN, NPY, FMOD, COL27A1, COMP, CHAT
10MP:00053908.1VCAN, COMP, COL27A1, FMOD, NPY, DCN

Publications for Tendinopathy

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50PubMed
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Articles related to Tendinopathy:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Comparing PRP Injections With ESWT for Athletes With Chronic Patellar Tendinopathy. (24366015)
2014
2
Polymorphisms in TNC and COL5A1 genes are associated with risk of superficial digital flexor tendinopathy in National Hunt Thoroughbred racehorses. (23906005)
2013
3
Transcatheter arterial embolization using imipenem/cilastatin sodium for tendinopathy and enthesopathy refractory to nonsurgical management. (23707086)
2013
4
Multiple percutaneous longitudinal tenotomies for chronic achilles tendinopathy in runners: a long-term study. (23841991)
2013
5
Surgical management of chronic proximal hamstring tendinopathy in athletes: a 2 to 11A years of follow-up. (23397447)
2013
6
What is the best clinical test for Achilles tendinopathy? (23548453)
2013
7
Altered fate of tendon-derived stem cells isolated from a failed tendon-healing animal model of tendinopathy. (23106341)
2013
8
Heated lidocaine/tetracaine patch for treatment of patellar tendinopathy pain. (23888118)
2013
9
Development of a self-managed loaded exercise programme for rotator cuff tendinopathy. (23480845)
2013
10
Impact of autologous blood injections in treatment of mid-portion Achilles tendinopathy: double blind randomised controlled trial. (23599320)
2013
11
No difference in effectiveness between focused and radial shockwave therapy for treating patellar tendinopathy: a randomized controlled trial. (23666379)
2013
12
Effectiveness of Platelet-rich Plasma Injection for Rotator Cuff Tendinopathy: A Prospective Open-label Study. (24416661)
2013
13
Further characterisation of an experimental model of tendinopathy in the horse. (23448172)
2013
14
Surgical treatment of chronic achilles tendinopathy: long-term results of the endoscopic technique. (23643200)
2013
15
A multidisciplinary approach including the use of platelet-rich plasma to treat an elite athlete with patellar tendinopathy - a case report. (24302777)
2013
16
Development and validation of a new visa questionnaire (VISA-H) for patients with proximal hamstring tendinopathy. (23470447)
2013
17
Use of autologous growth factors in aging tendon and chronic tendinopathy. (23747906)
2013
18
The effectiveness of extracorporeal shock wave therapy on chronic achilles tendinopathy: a systematic review. (23386759)
2013
19
Heat shock proteins in tendinopathy: novel molecular regulators. (23258952)
2012
20
Achilles tendinoscopy and plantaris tendon release and division in the treatment of non-insertional Achilles tendinopathy. (22444000)
2012
21
Calcific tendinopathy of the pectoralis major insertion with intracortical protrusion of calcification. (23405498)
2012
22
Risk factors for patellar tendinopathy: a systematic review of the literature. (21367808)
2011
23
Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow tendinopathy: a prospective, single-blind, randomised trial of autologous blood injections versus platelet-rich plasma injections. (21406450)
2011
24
No effects of PRP on ultrasonographic tendon structure and neovascularisation in chronic midportion Achilles tendinopathy. (21047840)
2011
25
Ultrasound-guided injections of hyperosmolar dextrose for overuse patellar tendinopathy: a pilot study. (21343141)
2011
26
Extra-corporeal pulsed-activated therapy ("EPAT" sound wave) for Achilles tendinopathy: a prospective study. (21406328)
2011
27
The impact of physically demanding work of basketball and volleyball players on the risk for patellar tendinopathy and on work limitations. (21248400)
2011
28
Treatment of chronic tendinopathy with ultrasound-guided needle tenotomy and platelet-rich plasma injection. (21872551)
2011
29
Mechanisms of rotator cuff tendinopathy: intrinsic, extrinsic, or both? (20846766)
2011
30
Patellar tendinopathy in master track and field athletes: influence of impact profile, weight, height, age and gender. (21057939)
2011
31
Longitudinal microvascularity in Achilles tendinopathy (power Doppler ultrasound, magnetic resonance imaging time-intensity curves and the Victorian Institute of Sport Assessment-Achilles questionnaire): a pilot study. (19711073)
2010
32
Autologous blood versus corticosteroid local injection in the short-term treatment of lateral elbow tendinopathy: a randomized clinical trial of efficacy. (20463564)
2010
33
Low level laser treatment of tendinopathy: a systematic review with meta-analysis. (19708800)
2010
34
Nonoperative treatment of midportion Achilles tendinopathy: a review. (20051741)
2010
35
Lateral elbow tendinopathy. (20971969)
2010
36
The short-term effects of high volume image guided injections in resistant non-insertional Achilles tendinopathy. (19944642)
2010
37
Letter to the editor: Minimally invasive paratenon release for non-insertional Achilles tendinopathy. (19830889)
2009
38
Fluoroquinolone-induced tendinopathy. (19114846)
2009
39
The prevalence of neovascularity in patients clinically diagnosed with rotator cuff tendinopathy. (20025761)
2009
40
Effect of ultrasound-guided, peritendinous injections of adalimumab and anakinra in chronic Achilles tendinopathy: a pilot study. (18492052)
2009
41
Efficacy of customised foot orthoses in the treatment of Achilles tendinopathy: study protocol for a randomised trial. (19852853)
2009
42
Eccentric loading for Achilles tendinopathy--strengthening or stretching? (19211585)
2009
43
Surgery for chronic Achilles tendinopathy produces worse results in women. (18608368)
2008
44
Calcific tendinopathy of the rotator cuff. Conservative management with 434 Mhz local microwave diathermy (hyperthermia): a case study. (18608369)
2008
45
Surgical management of tendinopathy of biceps femoris tendon in athletes. (18608398)
2008
46
Sclerosing injections in midportion Achilles tendinopathy: a retrospective study of 25 patients. (18551276)
2008
47
Adiposity and tendinopathy. (18608380)
2008
48
What are causes and treatment strategies for patellar-tendinopathy in female runners? (18538775)
2008
49
Oxygen species and overuse tendinopathy in athletes. (19005916)
2008
50
Versican splice variant messenger RNA expression in normal human Achilles tendon and tendinopathies. (15138331)
2004

Genetic Variations for Tendinopathy

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Expression for genes affiliated with Tendinopathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tendinopathy

Search GEO for disease gene expression data for Tendinopathy.

Pathways for genes affiliated with Tendinopathy

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Sources:
53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 52R&D Systems, 12EMD Millipore
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Pathways related to Tendinopathy according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1MMP3, COL5A1
210.0SLC18A3, CHAT
3
Hide members
10.0MMP8, MMP3, COL5A1
4
Hide members
10.0MMP3, MMP8, MMP1
5
Hide members
9.9COL27A1, COL5A1, COMP
69.8IL1R1, COL27A1, COL5A1
79.8NOS3, MMP1, DCN
89.8GRIN1, IL1R1, ACAN, VCAN
9
Hide members
9.7COMP, COL5A1, COL27A1, TNC
10
Hide members
9.6FMOD, DCN, ACAN, VCAN
119.6COMP, FMOD, DCN, ACAN
12
Cell adhesion Cell-matrix glycoconjugates
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9.6TNC, MMP3, MMP1, ACAN, VCAN
13
Hide members
9.4FMOD, TNC, DCN, ACAN, VCAN
14
Hide members
9.3COL5A1, COL27A1, TNC, MMP3, MMP8, MMP1
159.2COMP, COL5A1, COL27A1, TNC, CHRM2, NOS3
16
Cell adhesion ECM remodeling
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9.1FMOD, TNC, MMP3, MMP8, MMP1, ACAN
17
Hide members
8.3VCAN, COMP, COL5A1, COL27A1, FMOD, TNC

Compounds for genes affiliated with Tendinopathy

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Tendinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CHAT
2procollagen4410.5FMOD, ACAN
3(4-aminophenyl)mercuric acetate4410.4MMP3, MMP8
4leflunomide49 44 1112.1IL1R1, COMP, MMP1, MMP3
5neurocan4410.1ACAN, VCAN, TNC, DCN
6etanercept44 49 1112.1MMP1, MMP3, IL1R1, COMP
7dermatan44 2411.1DCN, ACAN, VCAN
8glutamate4410.1CHAT, GRIN1, SLC18A3, NPY
9dexamethasone44 49 28 1113.1ACAN, IL1R1, CHAT, DCN
10infliximab44 49 1112.0COMP, IL1R1, MMP1, MMP3
11alginate4410.0COMP, VCAN, ACAN, MMP3, DCN
12gi 254023x5910.0MMP1, MMP8, MMP3
13acetylcholine44 49 28 11 2413.9CHRM2, CHAT, MMP3, SLC18A3
14adalimumab44 49 1111.9MMP3, COMP, IL1R1
15dermatan sulfate449.9VCAN, DCN, FMOD, COMP, ACAN
16chondroitin44 2410.9DCN, MMP3, FMOD, VCAN, ACAN
17prednisolone44 28 1111.9MMP3, IL1R1, NPY, COMP, MMP1
18matrigel449.8ACTC1, NOS3, DCN, MMP1, MMP3
19formaldehyde44 2410.8CHAT, NPY, TNC, ACTC1, MMP1
20nicotine44 49 28 1112.8NPY, MMP1, GRIN1, CHRM2, CHAT
21cocaine44 1110.8CHAT, GRIN1, NPY, CHRM2, SLC18A3
22keratan sulfate449.7VCAN, ACAN, DCN, COMP, MMP3, FMOD
23ribonucleic acid449.7ACTC1, MMP3, IL1R1, MMP1, DCN, GRIN1
24methotrexate44 49 1111.7MMP1, COMP, IL1R1, MMP3, NOS3
25gm 6001599.7MMP1, MMP8, MMP3
26norepinephrine44 11 2411.6MMP1, IL1R1, GRIN1, CHRM2, CHAT, NPY
27choline44 11 2411.6NPY, NOS3, SLC18A3, CHRM2, CHAT
28heparin44 28 11 2412.6MMP3, DCN, IL1R1, VCAN
29ascorbic acid44 2410.6ACAN, TNC, IL1R1, MMP3, MMP1, NOS3
30tgf beta1449.6COMP, TNC, MMP3, MMP1, ACAN, VCAN
31gaba449.6CHRM2, TNC, GRIN1, NPY, CHAT
32cyclosporin a44 28 5911.6MMP3, MMP1, IL1R1, DCN, ACTC1, MMP8
33lactate449.6MMP1, MMP8, MMP3, IL1R1, NPY, COMP
34pd 98,059449.6DCN, CHAT, MMP3, MMP1, ACAN, NOS3
35pge2449.5IL1R1, ACAN, MMP8, MMP1, DCN, MMP3
36chondroitin sulfate44 2410.5COMP, FMOD, TNC, DCN, MMP3, ACAN
37progesterone44 59 28 11 2413.5ACTC1, MMP1, MMP3, IL1R1, TNC, CHAT
38creatinine449.3ACTC1, COMP, TNC, NPY, DCN, IL1R1
39paraffin449.3DCN, TNC, NPY, ACTC1, MMP1, CHAT
40oligonucleotide449.3COMP, GRIN1, IL1R1, MMP1, VCAN, MMP8
41zinc44 2410.2MMP3, GRIN1, MMP8, CHRM2, IL1R1, MMP1
42glucose449.2ACTC1, MMP8, VCAN, COMP, NPY, DCN
43vegf449.1MMP8, MMP1, NOS3, TNC, DCN, ACTC1
44hyaluronic acid44 2410.1TNC, FMOD, DCN, MMP3, MMP1, ACAN
45cysteine449.1SLC18A3, MMP1, MMP8, MMP3, IL1R1, GRIN1
46glycosaminoglycan449.0ACAN, COMP, DCN, VCAN, FMOD, TNC
47nitric oxide44 11 2410.8MMP8, NPY, ACAN, NOS3, SLC18A3, IL1R1
48calcium44 49 11 2411.6MMP8, MMP1, NOS3, ACTC1, COMP, MMP3
49tyrosine448.5CHRM2, CHAT, DCN, TNC, FMOD, GRIN1
50retinoic acid44 249.1COMP, TNC, NPY, CHAT, GRIN1, IL1R1

GO Terms for genes affiliated with Tendinopathy

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Sources:
16Gene Ontology
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Cellular components related to Tendinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.6VCAN, ACAN, DCN, FMOD
2lysosomal lumenGO:0432029.3FMOD, DCN, ACAN, VCAN
3proteinaceous extracellular matrixGO:0055789.2COMP, FMOD, MMP3, MMP8, MMP1, ACAN
4extracellular matrixGO:0310129.2COMP, COL5A1, FMOD, TNC, DCN, ACAN
5extracellular spaceGO:0056158.8COMP, FMOD, TNC, NPY, DCN, MMP3
6extracellular regionGO:0055768.0VCAN, COMP, COL5A1, COL27A1, FMOD, TNC

Biological processes related to Tendinopathy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1chondroitin sulfate catabolic processGO:03020710.1VCAN, DCN
2dermatan sulfate biosynthetic processGO:03020810.0VCAN, DCN
3collagen catabolic processGO:03057410.0COL5A1, MMP3, MMP8, MMP1
4extracellular matrix disassemblyGO:0226179.9COL5A1, MMP3, MMP8, MMP1
5keratan sulfate catabolic processGO:0423409.7ACAN, FMOD
6glycosaminoglycan metabolic processGO:0302039.7VCAN, ACAN, DCN, FMOD
7cell adhesionGO:0071559.6COMP, COL5A1, TNC, ACAN, VCAN
8extracellular matrix organizationGO:0301988.5VCAN, COMP, COL5A1, COL27A1, FMOD, TNC

Molecular functions related to Tendinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422210.0MMP1, MMP8, MMP3
2extracellular matrix structural constituentGO:0052019.6ACAN, COL27A1, COL5A1, COMP
3calcium ion bindingGO:0055099.2COMP, GRIN1, MMP3, MMP8, MMP1, VCAN

Products for genes affiliated with Tendinopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tendinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet