MCID: TND004
MIFTS: 38

Tendinopathy malady

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Summaries for Tendinopathy

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Tendinopathy refers to a disease of a tendon. More specifically, it can refer to: more...

MalaCards: Tendinopathy is related to pseudoachondroplasia and multiple epiphyseal dysplasia. An important gene associated with Tendinopathy is MIR608 (microRNA 608), and among its related pathways are Cell adhesion ECM remodeling and ECM proteoglycans. The compounds dermatan sulfate and pentosidine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and spinal cord.

Aliases & Classifications for Tendinopathy

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Sources:
33MalaCards, 31LifeMap Discovery™, 62UMLS
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Aliases & Descriptions:

tendinopathy 33 31 62


Related Diseases for Tendinopathy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tendinopathy:



Diseases related to tendinopathy

Symptoms for Tendinopathy

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Drugs & Therapeutics for Tendinopathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Tendinopathy

Search NIH Clinical Center for Tendinopathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Tendinopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Tendinopathy:
Autologous tenocyte implantation for damaged tendons
Embryonic/Adult Cultured Cells Related to Tendinopathy:
Tenocytes, PMIDs: 24068695, 23314880

Genetic Tests for Tendinopathy

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Anatomical Context for Tendinopathy

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Sources:
33MalaCards
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MalaCards organs/tissues related to Tendinopathy:

33
Bone, Testes, Spinal cord, Bone marrow, Whole blood, Endothelial

Animal Models for Tendinopathy or affiliated genes

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Publications for Tendinopathy

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52PubMed
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Articles related to Tendinopathy:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
The correlation of Achilles tendinopathy and body mass index. (23687344)
2013
2
Beneficial effects of autologous bone marrow-derived mesenchymal stem cells in naturally occurring tendinopathy. (24086616)
2013
3
Tendinopathy a89 from basic science to treatment. (24003459)
2013
4
MMP-1 promoter polymorphism is associated with primary tendinopathy of the posterior tibial tendon. (23389922)
2013
5
Polymorphisms in TNC and COL5A1 genes are associated with risk of superficial digital flexor tendinopathy in National Hunt Thoroughbred racehorses. (23906005)
2013
6
Mid- and long-term efficacy of the arthroscopic patellar release for treatment of patellar tendinopathy unresponsive to nonoperative management. (23830221)
2013
7
Transcatheter arterial embolization using imipenem/cilastatin sodium for tendinopathy and enthesopathy refractory to nonsurgical management. (23707086)
2013
8
Multiple percutaneous longitudinal tenotomies for chronic achilles tendinopathy in runners: a long-term study. (23841991)
2013
9
Don't miss familial hypercholesterolaemia in Achilles tendinopathy. (23615584)
2013
10
Open Patellar Tendon Debridement for Treatment of Recalcitrant Patellar Tendinopathy: Indications, Technique, and Clinical Outcomes After a 2-Year Minimum Follow-up. (24427403)
2013
11
Asymptomatic Achilles, patellar, and quadriceps tendinopathy: a longitudinal clinical and ultrasonographic study in elite fencers. (22092963)
2013
12
Polymorphisms within the COL5A1 3'-UTR that alters mRNA structure and the MIR608 gene are associated with Achilles tendinopathy. (23347277)
2013
13
Tendinopathy treatment: where is the evidence? (22341021)
2012
14
Presentation and conservative management of acute calcific tendinopathy: a case study and literature review. (22388055)
2012
15
Chronic insertional Achilles tendinopathy: surgical outcomes. (23738280)
2012
16
Tendinopathy in sport. (23016086)
2012
17
Evaluation of a diode laser for use in induction of tendinopathy in the superficial digital flexor tendon of horses. (22924726)
2012
18
Electromyographic analysis of an eccentric calf muscle exercise in persons with and without Achilles tendinopathy. (22814448)
2012
19
Use of platelet rich plasma for the treatment of bicipital tendinopathy in spinal cord injury:: a pilot study. (23459023)
2012
20
Risk factors for patellar tendinopathy in basketball and volleyball players: a cross-sectional study. (21496108)
2012
21
Comparing the effects of eccentric training with eccentric training and static stretching exercises in the treatment of patellar tendinopathy. A controlled clinical trial. (21856721)
2012
22
Ultrasound-guided injection of platelet-rich plasma in chronic Achilles and patellar tendinopathy. (23730392)
2012
23
Risk factors for superficial digital flexor tendinopathy in Thoroughbred racehorses in hurdle starts in the UK (2001-2009). (22372389)
2012
24
Is compressive load a factor in the development of tendinopathy? (22113234)
2012
25
Incidence of midportion Achilles tendinopathy in the general population. (21926076)
2011
26
Tendinopathy: no longer a 'one size fi ts all' diagnosis. (21513085)
2011
27
Risk factors for patellar tendinopathy: a systematic review of the literature. (21367808)
2011
28
Longitudinal microvascularity in Achilles tendinopathy (power Doppler ultrasound, magnetic resonance imaging time-intensity curves and the Victorian Institute of Sport Assessment-Achilles questionnaire): a pilot study. (19711073)
2010
29
Novel approaches for the management of tendinopathy. (21048180)
2010
30
The pathogenesis of tendinopathy: balancing the response to loading. (20308995)
2010
31
Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. (20068208)
2010
32
Platelet-rich plasma for treatment of Achilles tendinopathy. (20442383)
2010
33
Adductor tendinopathy in a hockey player with persistent groin pain: a case report. (21120018)
2010
34
Bringing Achilles tendinopathy to heel. (20844392)
2010
35
Expression of bone morphogenetic protein-2 in the chondrogenic and ossifying sites of calcific tendinopathy and traumatic tendon injury rat models. (19622147)
2009
36
High- versus low-energy extracorporeal shock wave therapy of rotator cuff tendinopathy: a prospective, randomised, controlled study. (19774810)
2009
37
Comparing the effects of exercise program and low-level laser therapy with exercise program and polarized polychromatic non-coherent light (bioptron light) on the treatment of lateral elbow tendinopathy. (19473072)
2009
38
Letter to the editor: Minimally invasive paratenon release for non-insertional Achilles tendinopathy. (19830889)
2009
39
Kinematic analysis of runners with achilles mid-portion tendinopathy. (20003878)
2009
40
Interobserver reliability of neovascularization score using power Doppler ultrasonography in midportion achilles tendinopathy. (19359416)
2009
41
The patellar tendinopathy in athletes: a sonographic grading correlated to prognosis and therapy. (18560913)
2008
42
Minimally invasive stripping for chronic Achilles tendinopathy. (18608390)
2008
43
5-HT3 receptor antagonist for the treatment of tendinopathy. (18587426)
2008
44
Eccentric calf muscle training in athletic patients with Achilles tendinopathy. (18608370)
2008
45
Assessing clinically diagnosed patellar tendinopathy with magnetic resonance imaging and ultrasound. (18469581)
2008
46
VISA-P score for patellar tendinopathy in males: adaptation to Italian. (18720116)
2008
47
Molecular and clinical developments in tendinopathy: editorial comment. (18459029)
2008
48
Surgery for chronic Achilles tendinopathy produces worse results in women. (18608368)
2008
49
Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy. (16219640)
2006
50
Histopathology of common tendinopathies. Update and implications for clinical management. (10418074)
1999

Variations for Tendinopathy

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Expression for genes affiliated with Tendinopathy

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tendinopathy

Search GEO for disease gene expression data for Tendinopathy.

Pathways for genes affiliated with Tendinopathy

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Sources:
50PathCards, 60Thomson Reuters, 12EMD Millipore, 55Reactome, 54R&D Systems, 38NCBI BioSystems Database
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Pathways related to Tendinopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5ACAN, MMP8
29.3ACAN, COMP
39.3COMP, ACAN
49.1GRIN1, ACAN
5
Show member pathways
8.4COL5A1, COMP, ACAN, MMP8

Compounds for genes affiliated with Tendinopathy

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Sources:
45Novoseek, 24HMDB, 11DrugBank
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Compounds related to Tendinopathy according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1dermatan sulfate4510.1COMP
2pentosidine459.6COMP, ACAN
3keratan sulfate459.6COMP, ACAN
4alginate459.6ACAN, COMP
5p002459.6COMP, MMP8
6procollagen459.6ACAN, COMP
7chondroitin sulfate45 2410.6COMP, ACAN
8sulfate45 2410.4COMP, ACAN
9tgf beta1459.4COMP, ACAN
10agarose459.3ACAN, COMP
11hyaluronic acid45 2410.2COMP, ACAN
12glycosaminoglycan459.2COMP, ACAN, MMP8
13proline459.1COMP, ACAN, MMP8
14nitric oxide45 24 1110.8MMP8, ACAN, GRIN1
15oligonucleotide458.8MMP8, COMP, GRIN1
16lipid458.6GRIN1, COMP, MMP8
17retinoic acid45 249.4MMP8, ACAN, COMP, GRIN1
18cysteine458.3GRIN1, COMP, MMP8

GO Terms for genes affiliated with Tendinopathy

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16Gene Ontology
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Cellular components related to Tendinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310128.7COL5A1, COMP, ACAN
2proteinaceous extracellular matrixGO:0055788.6MMP8, ACAN, COMP
3extracellular regionGO:0055768.4COL5A1, COMP, ACAN, MMP8

Biological processes related to Tendinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteolysisGO:0065089.5ACAN, MMP8
2collagen catabolic processGO:0305749.4COL5A1, MMP8
3extracellular matrix disassemblyGO:0226179.0COL5A1, ACAN, MMP8
4skeletal system developmentGO:0015019.0COMP, ACAN
5cell adhesionGO:0071558.8ACAN, COMP, COL5A1
6extracellular matrix organizationGO:0301988.5COL5A1, COMP, ACAN, MMP8

Molecular functions related to Tendinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.3COL5A1, COMP
2extracellular matrix structural constituentGO:0052018.7COL5A1, COMP, ACAN
3calcium ion bindingGO:0055098.3GRIN1, COMP, MMP8

Products for genes affiliated with Tendinopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tendinopathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet