Summaries for Tendinosis

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Wikipedia:63 Tendinosis, sometimes called chronic tendinitis, chronic tendinopathy, or chronic tendon injury, is... more...

MalaCards based summary: Tendinosis is related to astrocytoma and pigmented villonodular synovitis. An important gene associated with Tendinosis is CHAT (choline O-acetyltransferase), and among its related pathways are Acetylcholine Synthesis and TNF signaling pathway. The compounds physostigmine and ibotenic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and bone, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Aliases & Classifications for Tendinosis

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Sources:
31MalaCards, 30LifeMap Discovery®, 60UMLS
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Tendinosis, Aliases & Descriptions:

Name: Tendinosis 31 30 60


Related Diseases for Tendinosis

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Diseases related to Tendinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma30.2CNR1, PDGFRB, CXCL10, MMP3
2pigmented villonodular synovitis10.4PDGFRB
3fibromatosis10.4PDGFRB
4drug dependence10.4CNR1, CHRM2
5tendinitis10.4
6paracoccidioidomycosis10.3CXCL10, TNFRSF1A
7tendinopathy10.3
8congenital myasthenic syndrome10.3CHAT, ACHE
9amnestic disorder10.3ACHE, CHAT
10ganglioneuroblastoma10.3NPY, TH
11ewing sarcoma10.3CHAT, NPY
12neuronitis10.3
13brain disease10.3CXCL10, TH, CHAT
14alcohol dependence10.3CNR1, CHRM2, NPY
15vascular dementia10.2CHAT, ACHE
16biliary atresia10.2TIMP1, CXCL10
17central hypoventilation syndrome, congenital10.2BDNF, TH
18neonatal hypoxic and ischemic brain injury10.2TH, BDNF
19osteoporosis10.2CNR1, MMP3, NPY
20bulimia nervosa10.2NPY, BDNF
21noonan syndrome 110.2CNR1, CHRM2, TNFRSF1A
22congenital heart disease10.2CHRM2, MMP3, TNFRSF1A
23dementia, lewy body10.2ACHE, TH
24bursitis10.2
25chronic pain10.2
26localized scleroderma10.2DCN, MMP1
27central nervous system disease10.2CHAT, BDNF, CNR1
28kawasaki disease10.2TIMP1, MMP3
29supranuclear palsy, progressive10.2TH, CHAT, ACHE
30epidermolysis bullosa dystrophica10.2MMP1, MMP3
31pheochromocytoma10.1CHAT, NPY, SLC18A3, TH
32status epilepticus10.1BDNF, NPY, CNR1
33ganglioneuroma10.1NPY, TH
34eating disorder10.1CNR1, BDNF, NPY
35anxiety disorder10.1CNR1, BDNF, NPY
36anorexia nervosa10.1CNR1, NPY, BDNF
37rett syndrome10.1BDNF, CHAT, TH
38neuroblastoma10.1TH, CHAT, BDNF
39liver cirrhosis10.1NPY, TIMP1, CNR1
40primary hyperoxaluria10.1DCN, CXCL10, MMP3, NPY
41toxic encephalopathy10.1BDNF, CHAT, TH
42relapsing-remitting multiple sclerosis10.1TIMP1, BDNF
43galactosemia10.1NPY, CXCL10, CNR1, TNFRSF1A
44neurotic disorder10.1BDNF, TH, NPY
45metabolic syndrome x10.1ACHE, NPY, CNR1
46viral infectious disease10.1CXCL10, MMP3, CHRM2, TNFRSF1A
47oral submucous fibrosis10.1MMP1, TIMP1
48parkinson disease, late-onset10.1BDNF, TH, CNR1
49stroke, ischemic10.1CNR1, CHAT, TNFRSF1A, TH
50bipolar disorder10.0CNR1, BDNF, TH

Graphical network of the top 20 diseases related to Tendinosis:



Diseases related to tendinosis

Symptoms for Tendinosis

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Drugs & Therapeutics for Tendinosis

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Drug clinical trials:

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Genetic Tests for Tendinosis

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Anatomical Context for Tendinosis

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MalaCards organs/tissues related to Tendinosis:

31
Bone marrow, Bone

Animal Models for Tendinosis or affiliated genes

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MGI Mouse Phenotypes related to Tendinosis:

35 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7NPY, TNFRSF1A, DCN, CHRM2, PDGFRB
2MP:00053818.7TNFRSF1A, DCN, PDGFRB, BDNF, NPY, CNR1
3MP:00053758.5TNFRSF1A, ACHE, CNR1, PDGFRB, NPY, SLC17A6
4MP:00020068.4TIMP1, TNFRSF1A, DCN, TH, MMP1
5MP:00053918.3TH, DCN, CHRM2, ACHE, PDGFRB, BDNF
6MP:00028738.3SLC17A6, TH, CHAT, CNR1, PDGFRB, NPY
7MP:00053858.2TIMP1, TH, TNFRSF1A, CHAT, PDGFRB, CXCL10
8MP:00053848.2CNR1, DCN, CXCL10, TH, PDGFRB, BDNF
9MP:00053698.0ACHE, TNFRSF1A, DCN, CHAT, CHRM2, PDGFRB
10MP:00107718.0SLC17A6, BDNF, TH, CHRM2, TNFRSF1A, PDGFRB
11MP:00053978.0MMP3, TNFRSF1A, TIMP1, DCN, CXCL10, ACHE
12MP:00053907.9SLC18A3, NPY, PDGFRB, CNR1, TNFRSF1A, DCN
13MP:00030127.8TH, ACHE, BDNF, SLC18A3, SLC17A6, CNR1
14MP:00053897.8DCN, TIMP1, TNFRSF1A, CHAT, ACHE, BDNF
15MP:00053877.8PDGFRB, CXCL10, MMP1, MMP3, DCN, TNFRSF1A
16MP:00053887.5SLC17A6, TH, TNFRSF1A, TIMP1, DCN, CHRM2
17MP:00053866.6NPY, SLC17A6, TH, TNFRSF1A, DCN, CHRM2
18MP:00053786.5CNR1, PDGFRB, NPY, BDNF, SLC17A6, ACHE
19MP:00036316.0SLC17A6, SLC18A3, NPY, PDGFRB, CNR1, BDNF
20MP:00107685.9CNR1, PDGFRB, BDNF, SLC17A6, CXCL10, SLC18A3
21MP:00053764.6SLC17A6, CHAT, CHRM2, CXCL10, ACHE, CNR1

Publications for Tendinosis

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Articles related to Tendinosis:

(show all 43)
idTitleAuthorsYear
1
Peroneal tendinosis as a predisposing factor for the acute lateral ankle sprain in runners. (25786820)
2015
2
Quantitative MRI characterization of arthroscopically verified supraspinatus pathology: comparison of tendon tears, tendinosis and asymptomatic supraspinatus tendons with T2 mapping. (25739912)
2015
3
Achilles tendinosis: treatment options. (25729512)
2015
4
Percutaneous ultrasonic tenotomy for chronic elbow tendinosis: a prospective study. (25306494)
2014
5
The impact of posture on wrist tendinosis among blue-collar workers: the San Francisco study. (24669549)
2014
6
Sonoelastography findings of biceps tendinitis and tendinosis. (25368684)
2014
7
Plantar Flexor Muscle Architecture Changes as a Result of Eccentric Exercise in Patients With Achilles Tendinosis. (25037955)
2014
8
Combined intra-tendinous injection of Platelet Rich Plasma and bevacizumab accelerates and improves healing compared to Platelet Rich Plasma in tendinosis: comprehensive assessment on a rat model. (25489554)
2014
9
An Achilles tendinosis masking an intramedullary astrocytoma. (25322734)
2014
10
Trigger finger, tendinosis, and intratendinous gene expression. (22882155)
2014
11
Acute calcific tendinosis of the flexor hallucis brevis: case report. (23729205)
2013
12
The plantaris tendon in association with mid-portion Achilles tendinosis: tendinosis-like morphological features and presence of a non-neuronal cholinergic system. (23378267)
2013
13
Flexor hallucis longus tendon transfer in treatment of Achilles tendinosis. (23283373)
2013
14
Early weightbearing using Achilles suture bridge technique for insertional Achilles tendinosis: a review of 43 patients. (23669005)
2013
15
Dynamic contrast enhanced magnetic resonance imaging in chronic Achilles tendinosis. (24261480)
2013
16
Efficacy of intra-tendinous injection of platelet-rich plasma in treating tendinosis: comprehensive assessment of a rat model. (23801419)
2013
17
Injectable treatments for noninsertional achilles tendinosis: a systematic review. (23637232)
2013
18
Platelet rich plasma treatment for chronic Achilles tendinosis. (22735279)
2012
19
Effects of tendon viscoelasticity in Achilles tendinosis on explosive performance and clinical severity in athletes. (22830527)
2012
20
Tendinopathy: why the difference between tendinitis and tendinosis matters. (22553479)
2012
21
Eccentric training for the rehabilitation of a high level wrestler with distal biceps tendinosis: a case report. (22893861)
2012
22
Ultrasonographic evaluation of canine supraspinatus calcifying tendinosis. (23033462)
2012
23
Is calcaneal inclination higher in patients with insertional Achilles tendinosis? A case-controlled, cross-sectional study. (22819613)
2012
24
Is percutaneous radiofrequency coblation for treatment of Achilles tendinosis safe and effective? (22974813)
2012
25
Achilles tendon reattachment after surgical treatment of insertional tendinosis using the suture bridge technique: a case series. (22579354)
2012
26
Increased expression of cannabinoid CBa88 receptors in Achilles tendinosis. (21931835)
2011
27
Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors: a pilot study. (21819445)
2011
28
Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy-peptidergic elevation preceding tendinosis-like tissue changes. (21625050)
2011
29
VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes. (18050306)
2008
30
Autologous bone marrow plasma injection after arthroscopic debridement for elbow tendinosis. (18695767)
2008
31
Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy). (17999088)
2008
32
In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis. (17661370)
2007
33
Extensive expression of markers for acetylcholine synthesis and of M2 receptors in tenocytes in therapy-resistant chronic painful patellar tendon tendinosis - a pilot study. (17289083)
2007
34
Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man. (17206652)
2007
35
Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. (16830327)
2006
36
Calcific tendinosis and periarthritis: classic magnetic resonance imaging appearance and associated findings. (15100546)
2004
37
Tennis elbow tendinosis (epicondylitis). (15116648)
2004
38
cDNA-arrays and real-time quantitative PCR techniques in the investigation of chronic Achilles tendinosis. (14554207)
2003
39
Increased expression of matrix metalloproteinase 1 (MMP1) in 11 patients with patellar tendinosis. (12553513)
2002
40
Increased cell proliferation and associated expression of PDGFRbeta causing hypercellularity in patellar tendinosis. (11285371)
2001
41
Re: "Comparison of results of retrocalcaneal decompression for retrocalcaneal bursitis and insertional Achilles tendinosis with calcific spur" by Dr. Anthony Watson et. al. (11475463)
2001
42
Expression of transforming growth factor-beta isoforms and their receptors in chronic tendinosis. (11554502)
2001
43
Comparison of results of retrocalcaneal decompression for retrocalcaneal bursitis and insertional achilles tendinosis with calcific spur. (10966360)
2000

Variations for Tendinosis

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Expression for genes affiliated with Tendinosis

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Search GEO for disease gene expression data for Tendinosis.

Pathways for genes affiliated with Tendinosis

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Pathways related to Tendinosis according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CHAT, ACHE
29.6CXCL10, MMP3, TNFRSF1A
3
Show member pathways
catecholamine biosynthesis36
9.5TH, CHAT, ACHE
49.3MMP1, TIMP1
59.2TNFRSF1A, ACHE, BDNF
69.2BDNF, CHRM2, CHAT, TH
7
Show member pathways
Metalloproteases in connective tissue degradation
9.0MMP1, MMP3, TIMP1
8
Show member pathways
9.0TIMP1, MMP3, MMP1
9
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells58
Oncostatin M Signaling Pathway36
9.0TIMP1, MMP3, MMP1
10
Show member pathways
8.8MMP3, CHRM2, CXCL10, CNR1, PDGFRB, NPY
11
Show member pathways
8.8TIMP1, DCN, MMP3, MMP1
12
Show member pathways
8.7BDNF, PDGFRB, TIMP1, TH
13
Show member pathways
8.7TNFRSF1A, TIMP1, PDGFRB, BDNF
148.7SLC18A3, ACHE, CHAT, TH
15
Show member pathways
8.5TNFRSF1A, TIMP1, CXCL10, PDGFRB, BDNF
16
Show member pathways
8.5TNFRSF1A, TIMP1, CXCL10, PDGFRB, BDNF
17
Show member pathways
8.5TNFRSF1A, TIMP1, CXCL10, PDGFRB, BDNF
18
Show member pathways
8.5TNFRSF1A, TIMP1, CXCL10, PDGFRB, BDNF
19
Show member pathways
8.3BDNF, PDGFRB, MMP1, MMP3, TIMP1
20
Show member pathways
7.7TH, CHAT, CHRM2, ACHE, CNR1, SLC18A3

Compounds for genes affiliated with Tendinosis

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Compounds related to Tendinosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1physostigmine43 1210.7ACHE, CNR1, CHRM2, CHAT
2ibotenic acid439.5TH, CHAT, NPY
3desipramine43 49 1211.2BDNF, CNR1, TH, CHRM2
4kainate43 2810.2CHAT, BDNF, NPY, CNR1, TH
55-hydroxytryptamine439.1CHRM2, CHAT, TH, NPY, CNR1
6hydroxamate439.0MMP1, MMP3, TIMP1, TNFRSF1A
7haloperidol43 49 28 2 1212.9TH, CHAT, BDNF, NPY, MMP1
8tetrodotoxin43 59 2810.9TH, CHRM2, BDNF, ACHE, CNR1, NPY
9carbachol43 28 1210.8CHRM2, TH, ACHE, CNR1, NPY, BDNF
10infliximab43 49 1210.8MMP1, MMP3, CXCL10, TNFRSF1A, TIMP1
11glycosaminoglycan438.8MMP1, DCN, CXCL10, TIMP1, MMP3
12leflunomide43 49 1210.8PDGFRB, MMP1, TNFRSF1A, MMP3, TIMP1
13nicotine43 28 49 1211.6CNR1, CHAT, CHRM2, ACHE, NPY, MMP1
14nmda43 289.6BDNF, NPY, CNR1, CHAT, TH, ACHE
15gaba438.5CNR1, CHRM2, CHAT, BDNF, NPY, TH
16tgf beta1438.5PDGFRB, MMP3, DCN, TIMP1, TNFRSF1A, MMP1
17forskolin43 49 1210.4CHRM2, NPY, CXCL10, BDNF, MMP3, TNFRSF1A
18cyclic amp43 249.4BDNF, CXCL10, CNR1, CHRM2, CHAT, TNFRSF1A
19ribonucleic acid438.4TIMP1, MMP3, DCN, TNFRSF1A, PDGFRB, MMP1
20etanercept43 49 1210.4MMP3, TIMP1, TNFRSF1A, MMP1
21creatinine438.4MMP1, NPY, CXCL10, TNFRSF1A, DCN, MMP3
22adenylate438.3TH, CXCL10, BDNF, NPY, TIMP1, CHRM2
23cocaine43 129.3SLC18A3, CHRM2, TH, CHAT, CNR1, NPY
24aspartate438.2BDNF, CNR1, CHAT, DCN, TNFRSF1A, TIMP1
25pd 98,059438.2DCN, MMP3, MMP1, CHAT, BDNF, TIMP1
26matrigel438.2PDGFRB, BDNF, TIMP1, DCN, MMP1, CXCL10
27histamine43 28 2410.2BDNF, CHRM2, MMP3, TH, CXCL10, CNR1
28testosterone43 59 24 1211.1BDNF, NPY, MMP1, TNFRSF1A, TH, PDGFRB
29choline43 24 1210.1CHAT, TH, NPY, BDNF, SLC18A3, ACHE
30lactate438.1NPY, MMP3, CHAT, TIMP1, TH, BDNF
31indomethacin43 28 59 1211.1BDNF, NPY, CNR1, MMP3, TIMP1, TNFRSF1A
32cycloheximide438.0TNFRSF1A, BDNF, MMP1, MMP3, TIMP1, CHAT
33cholesterol43 28 24 1211.0TIMP1, BDNF, PDGFRB, CXCL10, TNFRSF1A, DCN
34dexamethasone43 49 28 1211.0MMP3, MMP1, TH, DCN, TIMP1, TNFRSF1A
35nitric oxide43 24 129.7TIMP1, NPY, TNFRSF1A, DCN, CHAT, CHRM2
36dopamine43 28 24 1210.7TH, CHAT, TNFRSF1A, ACHE, NPY, BDNF
37glucose437.7CNR1, BDNF, NPY, PDGFRB, SLC17A6, TNFRSF1A
38paraffin437.7DCN, MMP3, MMP1, NPY, TIMP1, CHAT
39norepinephrine43 24 129.6TH, TNFRSF1A, TIMP1, MMP1, CHRM2, NPY
40acetylcholine43 49 28 24 1211.6TH, SLC18A3, CHAT, MMP3, CHRM2, ACHE
41alanine437.5TNFRSF1A, CHAT, CHRM2, NPY, PDGFRB, CNR1
42vegf437.5TH, TNFRSF1A, TIMP1, BDNF, MMP3, MMP1
43calcium43 49 24 1210.4PDGFRB, CNR1, CHRM2, CXCL10, NPY, CHAT
44atp43 288.3PDGFRB, CXCL10, CHAT, MMP3, NPY, BDNF
45serine437.1ACHE, PDGFRB, CNR1, MMP1, MMP3, DCN
46cysteine437.0TH, TNFRSF1A, TIMP1, MMP1, MMP3, DCN
47tyrosine436.4MMP3, CHAT, DCN, TIMP1, TNFRSF1A, CHRM2
48retinoic acid43 247.2BDNF, NPY, PDGFRB, CXCL10, CHAT, MMP1
49glutamate436.0SLC17A6, TH, TNFRSF1A, TIMP1, DCN, MMP3
50estrogen435.9DCN, TH, TNFRSF1A, MMP1, CHAT, CHRM2

GO Terms for genes affiliated with Tendinosis

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Cellular components related to Tendinosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304249.5ACHE, CHAT, TNFRSF1A
2extracellular spaceGO:00056158.3TNFRSF1A, DCN, MMP3, CXCL10, ACHE, NPY
3extracellular regionGO:00055766.9BDNF, TNFRSF1A, TIMP1, DCN, MMP3, MMP1

Biological processes related to Tendinosis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.9NPY, CNR1, CHRM2
2regulation of heart contractionGO:00080169.9CHRM2, TH
3response to hyperoxiaGO:00550939.8BDNF, PDGFRB
4muscle organ developmentGO:00075179.8CHAT, CXCL10, ACHE
5neurotransmitter biosynthetic processGO:00421369.8TH, CHAT, ACHE
6response to ethanolGO:00454719.7TH, TNFRSF1A, CNR1
7phosphatidylcholine biosynthetic processGO:00066569.5ACHE, CHAT
8agingGO:00075689.4TIMP1, DCN, CNR1
9response to lipopolysaccharideGO:00324969.3CNR1, CXCL10, DCN, TNFRSF1A, TH
10response to hypoxiaGO:00016669.2BDNF, TNFRSF1A, TH
11extracellular matrix disassemblyGO:00226179.0TIMP1, DCN, MMP3, MMP1
12extracellular matrix organizationGO:00301989.0TIMP1, DCN, MMP3, MMP1
13synaptic transmissionGO:00072688.7CHAT, ACHE, NPY, SLC18A3

Products for genes affiliated with Tendinosis

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Sources for Tendinosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet