MCID: TND006
MIFTS: 40

Tendinosis malady

Summaries for Tendinosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Tendinosis, sometimes called chronic tendinitis, tendinosus, chronic tendinopathy, or chronic tendon... more...

MalaCards: Tendinosis is related to tendinopathy and tendinitis. An important gene associated with Tendinosis is CHAT (choline O-acetyltransferase), and among its related pathways are Acetylcholine Synthesis and TNF signaling pathway. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include bone and bone marrow, and related mouse phenotypes are vision/eye and respiratory system.

Aliases & Classifications for Tendinosis

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32MalaCards
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Aliases & Descriptions:

tendinosis 32


Related Diseases for Tendinosis

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17GeneCards, 18GeneDecks
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Diseases related to Tendinosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1tendinopathy10.3
2tendinitis10.1
3achilles bursitis10.1
4bursitis10.1
5dermatitis10.0CXCL10
6hepatitis10.0CXCL10
7pneumonia10.0CXCL10
8dermatofibrosarcoma protuberans10.0PDGFRB
9lewy body dementia10.0TH
10substance abuse10.0CNR1
11myelodysplastic syndromes10.0PDGFRB
12chagas disease10.0CHRM2
13major depressive disorder10.0CHRM2
14colon adenocarcinoma10.0TNFRSF1A
15myopia 610.0DCN
16meningitis10.0CXCL10
17coronary heart disease10.0NPY
18rhinitis10.0NPY
19encephalomyelitis10.0CXCL10, CNR1
20multiple system atrophy10.0TH, CHAT
21psoriasis10.0CXCL10, TNFRSF1A
22familial mediterranean fever10.0TNFRSF1A
23anxiety disorder10.0BDNF
24leiomyoma10.0MMP3
25myasthenia gravis10.0ACHE
26migraine10.0CNR1, CHRM2
27drug dependence10.0CNR1, CHRM2
28sarcoma10.0TH, PDGFRB
29uveitis10.0CXCL10, TNFRSF1A
30sarcoidosis10.0CXCL10, DCN
31encephalitis10.0CXCL10, CNR1
32sudden infant death syndrome10.0CHAT, TH
33hypertension10.0NPY, TH
34respiratory failure10.0NPY
35essential hypertension10.0NPY, TH
36frontotemporal dementia10.0ACHE
37rhabdomyosarcoma10.0PDGFRB
38glomerulonephritis10.0DCN
39adenoma10.0CNR1, DCN
40down syndrome10.0ACHE, CHAT
41brain disease10.0CHAT, CXCL10, TH
42neonatal hypoxic and ischemic brain injury10.0BDNF, TH
43central hypoventilation syndrome, congenital, with or without hirschsprung disease10.0BDNF, TH
44epidermolysis bullosa dystrophica10.0MMP3, MMP1
45congenital myasthenic syndrome10.0CHAT, ACHE
46pick's disease10.0CHAT, ACHE
47localized scleroderma10.0DCN, MMP1
48neuroblastoma10.0TH, CHAT, BDNF
49bulimia nervosa10.0NPY, BDNF
50obesity10.0MMP3, CNR1, NPY

Graphical network of the top 20 diseases related to Tendinosis:



Diseases related to tendinosis

Clinical Features for Tendinosis

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Drugs & Therapeutics for Tendinosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Tendinosis

Drug clinical trials:

Search ClinicalTrials for Tendinosis

Search NIH Clinical Center for Tendinosis

Search CenterWatch for Tendinosis

Genetic Tests for Tendinosis

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Anatomical Context for Tendinosis

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32MalaCards
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MalaCards organs/tissues related to Tendinosis:

32
Bone, Bone marrow

Animal Models for Tendinosis or affiliated genes

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36MGI
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Publications for Tendinosis

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50PubMed
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Articles related to Tendinosis:

(show all 19)
idTitleAuthorsYear
1
Tendinopathy: why the difference between tendinitis and tendinosis matters. (22553479)
2012
2
Increased expression of cannabinoid CBa88 receptors in Achilles tendinosis. (21931835)
2011
3
Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors: a pilot study. (21819445)
2011
4
Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy-peptidergic elevation preceding tendinosis-like tissue changes. (21625050)
2011
5
VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes. (18050306)
2008
6
Autologous bone marrow plasma injection after arthroscopic debridement for elbow tendinosis. (18695767)
2008
7
Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy). (17999088)
2008
8
In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis. (17661370)
2007
9
Extensive expression of markers for acetylcholine synthesis and of M2 receptors in tenocytes in therapy-resistant chronic painful patellar tendon tendinosis - a pilot study. (17289083)
2007
10
Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man. (17206652)
2007
11
Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. (16830327)
2006
12
Calcific tendinosis and periarthritis: classic magnetic resonance imaging appearance and associated findings. (15100546)
2004
13
Tennis elbow tendinosis (epicondylitis). (15116648)
2004
14
cDNA-arrays and real-time quantitative PCR techniques in the investigation of chronic Achilles tendinosis. (14554207)
2003
15
Increased expression of matrix metalloproteinase 1 (MMP1) in 11 patients with patellar tendinosis. (12553513)
2002
16
Increased cell proliferation and associated expression of PDGFRbeta causing hypercellularity in patellar tendinosis. (11285371)
2001
17
Re: "Comparison of results of retrocalcaneal decompression for retrocalcaneal bursitis and insertional Achilles tendinosis with calcific spur" by Dr. Anthony Watson et. al. (11475463)
2001
18
Expression of transforming growth factor-beta isoforms and their receptors in chronic tendinosis. (11554502)
2001
19
Comparison of results of retrocalcaneal decompression for retrocalcaneal bursitis and insertional achilles tendinosis with calcific spur. (10966360)
2000

Genetic Variations for Tendinosis

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Expression for genes affiliated with Tendinosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tendinosis

Search GEO for disease gene expression data for Tendinosis.

Pathways for genes affiliated with Tendinosis

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37NCBI BioSystems Database, 29KEGG, 53Reactome, 12EMD Millipore, 51QIAGEN, 49PharmGKB
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Pathways related to Tendinosis according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ACHE, CHAT
29.7MMP3, CXCL10, TNFRSF1A
3
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9.5ACHE, TH, CHAT
4
Cell adhesion ECM remodeling
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9.3TIMP1, MMP3, MMP1
5
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9.3TIMP1, MMP3, MMP1
6
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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9.3MMP1, MMP3, TIMP1
79.0TH, CHRM2, CHAT, BDNF
8
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8.9TIMP1, DCN, MMP3, MMP1
98.7ACHE, SLC18A3, TH, CHAT
10
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8.5TIMP1, BDNF, PDGFRB, TNFRSF1A, CXCL10
11
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8.5TIMP1, BDNF, PDGFRB, TNFRSF1A, CXCL10
12
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8.5TIMP1, BDNF, PDGFRB, TNFRSF1A, CXCL10
13
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8.4TIMP1, BDNF, PDGFRB, MMP3, MMP1
14
Hide members
7.6CHAT, CHRM2, CNR1, TH, SLC17A6, SLC18A3

Compounds for genes affiliated with Tendinosis

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB, 24HMDB, 59Tocris Bioscience
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Compounds related to Tendinosis according to GeneCards/GeneDecks:

(show top 50)    (show all 171)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CHAT
2cycloheximide4410.5CXCL10
3forskolin44 49 1112.0TH, CHAT, NPY
4ibotenic acid449.8TH, CHAT, NPY
5physostigmine44 1110.6CHAT, CHRM2, CNR1, ACHE
6glucose449.5PDGFRB, NPY, CHAT, SLC17A6
7dexamethasone44 49 28 1112.5TIMP1, DCN, CHAT, TH
8carbachol44 28 1111.5NPY, CHRM2, CNR1, ACHE
9uva 1449.4TIMP1, MMP3, MMP1
10matrigel449.4PDGFRB, DCN, CXCL10, MMP3, MMP1
11hydroxamate449.3TIMP1, TNFRSF1A, MMP3, MMP1
125-hydroxytryptamine449.2TH, CNR1, CHRM2, CHAT, NPY
13etanercept44 49 1111.1TIMP1, TNFRSF1A, MMP3, MMP1
14leflunomide49 44 1111.1TIMP1, PDGFRB, TNFRSF1A, MMP3, MMP1
15infliximab44 49 1111.1TIMP1, TNFRSF1A, CXCL10, MMP3, MMP1
16kainate44 2810.1BDNF, NPY, CHAT, CNR1, TH
17aspartate449.0BDNF, DCN, CHAT, CNR1, TH
18desipramine44 49 1111.0BDNF, CHRM2, CNR1, TH
19glycosaminoglycan449.0TIMP1, DCN, CXCL10, MMP3, MMP1
20haloperidol44 28 2 49 1112.9BDNF, NPY, CHAT, MMP1, TH
21cyclic amp44 249.8BDNF, NPY, CHAT, CHRM2, CNR1, TH
22nmda44 289.8BDNF, CHAT, CNR1, MMP3, TH, ACHE
23tgf beta1448.7TIMP1, PDGFRB, TNFRSF1A, DCN, MMP3, MMP1
24methamphetamine44 49 1110.7BDNF, NPY, CHAT, TH
25ribonucleic acid448.7TIMP1, PDGFRB, TNFRSF1A, DCN, MMP3, MMP1
26tetrodotoxin44 59 2810.6BDNF, NPY, CHRM2, CNR1, TH, ACHE
27nicotine44 49 28 1111.6NPY, CHAT, CHRM2, CNR1, MMP1, TH
28dopamine44 28 11 2411.3BDNF, NPY, CHAT, CNR1, TH, SLC18A3
29gaba448.3BDNF, NPY, CHAT, CHRM2, CNR1, TH
30glutamate448.2TNFRSF1A, NPY, CHAT, SLC17A6, SLC18A3, ACHE
31creatinine448.2BDNF, TNFRSF1A, NPY, DCN, CXCL10, MMP3
32pd 98,059448.1MMP1, MMP3, CHAT, DCN, BDNF, TIMP1
33adenylate448.1TIMP1, BDNF, NPY, CHRM2, CNR1, CXCL10
34lactate448.1TIMP1, BDNF, NPY, CHAT, MMP3, MMP1
35indomethacin44 59 28 1111.1TIMP1, BDNF, TNFRSF1A, NPY, CNR1, MMP3
36cocaine44 119.0BDNF, NPY, CHAT, CHRM2, CNR1, TH
37histamine44 28 2410.0TIMP1, BDNF, NPY, CHRM2, CNR1, CXCL10
38paraffin447.9TIMP1, PDGFRB, TNFRSF1A, NPY, DCN, CHAT
39testosterone44 59 11 2410.9BDNF, PDGFRB, TNFRSF1A, NPY, CHAT, MMP1
40cholesterol44 28 11 2410.9MMP3, CXCL10, DCN, TNFRSF1A, PDGFRB, BDNF
41choline44 11 249.8BDNF, NPY, CHAT, CHRM2, TH, SLC18A3
42acetylcholine44 49 28 11 2411.7BDNF, CHAT, CHRM2, CNR1, MMP3, TH
43nitric oxide44 11 249.7TIMP1, TNFRSF1A, NPY, DCN, CHAT, CHRM2
44norepinephrine44 11 249.6TIMP1, BDNF, TNFRSF1A, NPY, CHAT, CHRM2
45vegf447.6TIMP1, BDNF, PDGFRB, TNFRSF1A, DCN, CXCL10
46alanine447.6TIMP1, PDGFRB, TNFRSF1A, NPY, DCN, CHAT
47cysteine447.4TIMP1, PDGFRB, TNFRSF1A, DCN, CNR1, MMP3
48atp44 288.2BDNF, PDGFRB, TNFRSF1A, NPY, CHAT, CXCL10
49tyrosine446.3NPY, TNFRSF1A, PDGFRB, BDNF, TIMP1, DCN
50retinoic acid44 247.3TIMP1, BDNF, PDGFRB, TNFRSF1A, NPY, DCN

GO Terms for genes affiliated with Tendinosis

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16Gene Ontology
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Cellular components related to Tendinosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5NPY, DCN, CXCL10, MMP3, ACHE, TNFRSF1A
2extracellular regionGO:0055766.6ACHE, TIMP1, BDNF, TNFRSF1A, NPY, DCN

Biological processes related to Tendinosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1response to ethanolGO:0454719.8TH, CNR1, TNFRSF1A
2neurotransmitter biosynthetic processGO:0421369.7CHAT, TH, ACHE
3G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.7CNR1, CHRM2, NPY
4extracellular matrix disassemblyGO:0226179.3TIMP1, MMP3, MMP1
5response to hyperoxiaGO:0550939.3PDGFRB, BDNF
6response to lipopolysaccharideGO:0324969.3TH, CXCL10, CNR1, DCN, TNFRSF1A
7agingGO:0075689.3TIMP1, DCN, CNR1
8extracellular matrix organizationGO:0301988.9MMP1, MMP3, DCN, TIMP1
9synaptic transmissionGO:0072688.6ACHE, SLC18A3, CHAT, NPY

Products for genes affiliated with Tendinosis

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Sources for Tendinosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet