MCID: TND006
MIFTS: 43

Tendinosis malady

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Summaries for Tendinosis

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Wikipedia:65 Tendinosis, sometimes called chronic tendinitis, chronic tendinopathy, or chronic tendon injury, is... more...

MalaCards based summary: Tendinosis is related to astrocytoma and pigmented villonodular synovitis. An important gene associated with Tendinosis is CHAT (choline O-acetyltransferase), and among its related pathways are Acetylcholine Synthesis and TNF signaling pathway. The compounds physostigmine and ibotenic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and bone, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Aliases & Classifications for Tendinosis

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Sources:
32MalaCards, 30LifeMap Discovery®, 62UMLS
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Tendinosis, Aliases & Descriptions:

Name: Tendinosis 32 30 62


Related Diseases for Tendinosis

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Diseases related to Tendinosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma30.2MMP3, CXCL10, CNR1, PDGFRB
2pigmented villonodular synovitis10.4PDGFRB
3fibromatosis10.4PDGFRB
4drug dependence10.4CHRM2, CNR1
5paracoccidioidomycosis10.3TNFRSF1A, CXCL10
6congenital myasthenic syndrome10.3CHAT, ACHE
7tendinopathy10.3
8tendinitis10.3
9ganglioneuroblastoma10.3TH, NPY
10amnestic disorder10.3CHAT, ACHE
11neuroepithelioma10.3CHAT, NPY
12alcohol dependence10.3CHRM2, CNR1, NPY
13brain disease10.3CXCL10, CHAT, TH
14neuronitis10.3
15vascular dementia10.2CHAT, ACHE
16biliary atresia10.2TIMP1, CXCL10
17central hypoventilation syndrome, congenital, with or without hirschsprung disease10.2TH, BDNF
18neonatal hypoxic and ischemic brain injury10.2TH, BDNF
19osteoporosis10.2MMP3, CNR1, NPY
20bulimia nervosa10.2BDNF, NPY
21noonan syndrome10.2TNFRSF1A, CHRM2, CNR1
22congenital heart disease10.2TNFRSF1A, MMP3, CHRM2
23lewy body dementia10.2ACHE, TH
24localized scleroderma10.2DCN, MMP1
25central nervous system disease10.2CHAT, CNR1, BDNF
26bursitis10.2
27chronic pain10.2
28kawasaki disease10.2TIMP1, MMP3
29progressive supranuclear palsy10.2TH, CHAT, ACHE
30epidermolysis bullosa dystrophica10.2MMP3, MMP1
31status epilepticus10.1CNR1, NPY, BDNF
32pheochromocytoma10.1SLC18A3, NPY, CHAT, TH
33ganglioneuroma10.1NPY, TH
34eating disorder10.1CNR1, NPY, BDNF
35anxiety disorder10.1BDNF, NPY, CNR1
36anorexia nervosa10.1BDNF, NPY, CNR1
37rett syndrome10.1TH, CHAT, BDNF
38neuroblastoma10.1TH, CHAT, BDNF
39liver cirrhosis10.1NPY, CNR1, TIMP1
40primary hyperoxaluria10.1DCN, MMP3, CXCL10, NPY
41toxic encephalopathy10.1BDNF, CHAT, TH
42relapsing-remitting multiple sclerosis10.1TIMP1, BDNF
43galactosemia10.1TNFRSF1A, CXCL10, CNR1, NPY
44metabolic syndrome x10.1ACHE, CNR1, NPY
45viral infectious disease10.1TNFRSF1A, MMP3, CHRM2, CXCL10
46oral submucous fibrosis10.1TIMP1, MMP1
47parkinson's disease10.1BDNF, CNR1, TH
48cerebrovascular disease10.1TH, TNFRSF1A, CHAT, CNR1
49bipolar disorder10.1BDNF, CNR1, TH
50pulpitis10.1TIMP1, MMP1

Graphical network of the top 20 diseases related to Tendinosis:



Diseases related to tendinosis

Symptoms for Tendinosis

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Drugs & Therapeutics for Tendinosis

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Drug clinical trials:

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Genetic Tests for Tendinosis

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Anatomical Context for Tendinosis

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MalaCards organs/tissues related to Tendinosis:

32
Bone marrow, Bone

Animal Models for Tendinosis or affiliated genes

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MGI Mouse Phenotypes related to Tendinosis:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7TNFRSF1A, DCN, CHRM2, PDGFRB, NPY
2MP:00053818.7TNFRSF1A, DCN, CNR1, PDGFRB, NPY, BDNF
3MP:00053758.5TNFRSF1A, ACHE, CNR1, PDGFRB, NPY, SLC17A6
4MP:00020068.4TH, TNFRSF1A, TIMP1, DCN, MMP1
5MP:00053918.3TH, TNFRSF1A, DCN, CHRM2, ACHE, PDGFRB
6MP:00028738.3TH, CHAT, CNR1, PDGFRB, NPY, BDNF
7MP:00053858.2TH, TNFRSF1A, TIMP1, CHAT, CHRM2, CXCL10
8MP:00053848.2BDNF, PDGFRB, CNR1, CXCL10, DCN, TNFRSF1A
9MP:00053698.0TNFRSF1A, DCN, CHAT, CHRM2, ACHE, PDGFRB
10MP:00107718.0TH, TNFRSF1A, DCN, CHRM2, CNR1, PDGFRB
11MP:00053978.0TNFRSF1A, TIMP1, DCN, MMP3, CXCL10, ACHE
12MP:00053907.9TNFRSF1A, DCN, MMP3, CHAT, CNR1, PDGFRB
13MP:00030127.8TH, ACHE, CNR1, BDNF, SLC18A3, SLC17A6
14MP:00053897.8TNFRSF1A, TIMP1, DCN, CHAT, ACHE, CNR1
15MP:00053877.8TNFRSF1A, TIMP1, DCN, MMP3, MMP1, CXCL10
16MP:00053887.5TH, TNFRSF1A, TIMP1, DCN, CHRM2, ACHE
17MP:00053866.6TH, TNFRSF1A, DCN, CHAT, CHRM2, ACHE
18MP:00053786.5CHAT, DCN, TIMP1, TNFRSF1A, TH, CHRM2
19MP:00036316.0TH, TNFRSF1A, MMP3, CHAT, CHRM2, CXCL10
20MP:00107685.9CHAT, DCN, TIMP1, TNFRSF1A, TH, CXCL10
21MP:00053764.6SLC17A6, TH, TNFRSF1A, TIMP1, DCN, MMP3

Publications for Tendinosis

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Articles related to Tendinosis:

(show all 39)
idTitleAuthorsYear
1
Percutaneous ultrasonic tenotomy for chronic elbow tendinosis: a prospective study. (25306494)
2014
2
The impact of posture on wrist tendinosis among blue-collar workers: the San Francisco study. (24669549)
2014
3
Sonoelastography findings of biceps tendinitis and tendinosis. (25368684)
2014
4
Plantar Flexor Muscle Architecture Changes as a Result of Eccentric Exercise in Patients With Achilles Tendinosis. (25037955)
2014
5
An Achilles tendinosis masking an intramedullary astrocytoma. (25322734)
2014
6
Trigger finger, tendinosis, and intratendinous gene expression. (22882155)
2014
7
Acute calcific tendinosis of the flexor hallucis brevis: case report. (23729205)
2013
8
The plantaris tendon in association with mid-portion Achilles tendinosis: tendinosis-like morphological features and presence of a non-neuronal cholinergic system. (23378267)
2013
9
Flexor hallucis longus tendon transfer in treatment of Achilles tendinosis. (23283373)
2013
10
Early weightbearing using Achilles suture bridge technique for insertional Achilles tendinosis: a review of 43 patients. (23669005)
2013
11
Dynamic contrast enhanced magnetic resonance imaging in chronic Achilles tendinosis. (24261480)
2013
12
Efficacy of intra-tendinous injection of platelet-rich plasma in treating tendinosis: comprehensive assessment of a rat model. (23801419)
2013
13
Injectable treatments for noninsertional achilles tendinosis: a systematic review. (23637232)
2013
14
Platelet rich plasma treatment for chronic Achilles tendinosis. (22735279)
2012
15
Effects of tendon viscoelasticity in Achilles tendinosis on explosive performance and clinical severity in athletes. (22830527)
2012
16
Tendinopathy: why the difference between tendinitis and tendinosis matters. (22553479)
2012
17
Eccentric training for the rehabilitation of a high level wrestler with distal biceps tendinosis: a case report. (22893861)
2012
18
Ultrasonographic evaluation of canine supraspinatus calcifying tendinosis. (23033462)
2012
19
Is calcaneal inclination higher in patients with insertional Achilles tendinosis? A case-controlled, cross-sectional study. (22819613)
2012
20
Is percutaneous radiofrequency coblation for treatment of Achilles tendinosis safe and effective? (22974813)
2012
21
Achilles tendon reattachment after surgical treatment of insertional tendinosis using the suture bridge technique: a case series. (22579354)
2012
22
Increased expression of cannabinoid CBa88 receptors in Achilles tendinosis. (21931835)
2011
23
Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors: a pilot study. (21819445)
2011
24
Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy-peptidergic elevation preceding tendinosis-like tissue changes. (21625050)
2011
25
VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes. (18050306)
2008
26
Autologous bone marrow plasma injection after arthroscopic debridement for elbow tendinosis. (18695767)
2008
27
Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy). (17999088)
2008
28
In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis. (17661370)
2007
29
Extensive expression of markers for acetylcholine synthesis and of M2 receptors in tenocytes in therapy-resistant chronic painful patellar tendon tendinosis - a pilot study. (17289083)
2007
30
Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man. (17206652)
2007
31
Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. (16830327)
2006
32
Calcific tendinosis and periarthritis: classic magnetic resonance imaging appearance and associated findings. (15100546)
2004
33
Tennis elbow tendinosis (epicondylitis). (15116648)
2004
34
cDNA-arrays and real-time quantitative PCR techniques in the investigation of chronic Achilles tendinosis. (14554207)
2003
35
Increased expression of matrix metalloproteinase 1 (MMP1) in 11 patients with patellar tendinosis. (12553513)
2002
36
Increased cell proliferation and associated expression of PDGFRbeta causing hypercellularity in patellar tendinosis. (11285371)
2001
37
Re: "Comparison of results of retrocalcaneal decompression for retrocalcaneal bursitis and insertional Achilles tendinosis with calcific spur" by Dr. Anthony Watson et. al. (11475463)
2001
38
Expression of transforming growth factor-beta isoforms and their receptors in chronic tendinosis. (11554502)
2001
39
Comparison of results of retrocalcaneal decompression for retrocalcaneal bursitis and insertional achilles tendinosis with calcific spur. (10966360)
2000

Variations for Tendinosis

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Expression for genes affiliated with Tendinosis

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Expression patterns in normal tissues for genes affiliated with Tendinosis

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Pathways for genes affiliated with Tendinosis

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Pathways related to Tendinosis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CHAT, ACHE
29.6CXCL10, MMP3, TNFRSF1A
3
Show member pathways
catecholamine biosynthesis37
9.5TH, ACHE, CHAT
49.3MMP1, TIMP1
59.2BDNF, ACHE, TNFRSF1A
69.2TH, CHAT, BDNF, CHRM2
7
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
9.0MMP1, MMP3, TIMP1
8
Show member pathways
9.0MMP1, MMP3, TIMP1
9
Show member pathways
9.0MMP3, MMP1, TIMP1
10
Show member pathways
8.8MMP3, CNR1, CHRM2, CXCL10, PDGFRB, NPY
11
Show member pathways
8.8MMP1, MMP3, DCN, TIMP1
12
Show member pathways
8.7TIMP1, BDNF, TH, PDGFRB
13
Show member pathways
8.7BDNF, PDGFRB, TIMP1, TNFRSF1A
148.7SLC18A3, TH, CHAT, ACHE
15
Show member pathways
8.5TIMP1, CXCL10, PDGFRB, BDNF, TNFRSF1A
16
Show member pathways
8.5CXCL10, BDNF, TNFRSF1A, TIMP1, PDGFRB
17
Show member pathways
8.5PDGFRB, TIMP1, BDNF, CXCL10, TNFRSF1A
18
Show member pathways
8.5TNFRSF1A, TIMP1, CXCL10, PDGFRB, BDNF
19
Show member pathways
8.3MMP3, TIMP1, PDGFRB, MMP1, BDNF
20
Show member pathways
7.7SLC18A3, CHAT, CNR1, ACHE, CHRM2, TH

Compounds for genes affiliated with Tendinosis

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Compounds related to Tendinosis according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1physostigmine44 1110.7ACHE, CNR1, CHRM2, CHAT
2ibotenic acid449.5TH, CHAT, NPY
3desipramine44 50 1111.2BDNF, CNR1, TH, CHRM2
4kainate44 2810.2CHAT, BDNF, NPY, CNR1, TH
55-hydroxytryptamine449.1CHRM2, CHAT, TH, NPY, CNR1
6hydroxamate449.0MMP1, MMP3, TIMP1, TNFRSF1A
7haloperidol44 50 28 2 1112.9TH, CHAT, BDNF, NPY, MMP1
8tetrodotoxin44 61 2810.9TH, CHRM2, BDNF, ACHE, CNR1, NPY
9carbachol44 28 1110.8CHRM2, TH, ACHE, CNR1, NPY, BDNF
10infliximab44 50 1110.8MMP1, MMP3, CXCL10, TNFRSF1A, TIMP1
11glycosaminoglycan448.8MMP1, DCN, CXCL10, TIMP1, MMP3
12leflunomide44 50 1110.8PDGFRB, MMP1, TNFRSF1A, MMP3, TIMP1
13nicotine44 28 50 1111.6CNR1, CHAT, CHRM2, ACHE, NPY, MMP1
14nmda44 289.6BDNF, NPY, CNR1, CHAT, TH, ACHE
15gaba448.5CNR1, CHRM2, CHAT, BDNF, NPY, TH
16tgf beta1448.5PDGFRB, MMP3, DCN, TIMP1, TNFRSF1A, MMP1
17forskolin44 50 1110.4CHRM2, NPY, CXCL10, BDNF, MMP3, TNFRSF1A
18cyclic amp44 249.4BDNF, CXCL10, CNR1, CHRM2, CHAT, TNFRSF1A
19ribonucleic acid448.4TIMP1, MMP3, DCN, TNFRSF1A, PDGFRB, MMP1
20etanercept44 50 1110.4MMP3, TIMP1, TNFRSF1A, MMP1
21creatinine448.4MMP1, NPY, CXCL10, TNFRSF1A, DCN, MMP3
22adenylate448.3TH, CXCL10, BDNF, NPY, TIMP1, CHRM2
23cocaine44 119.3SLC18A3, CHRM2, TH, CHAT, CNR1, NPY
24aspartate448.2BDNF, CNR1, CHAT, DCN, TNFRSF1A, TIMP1
25pd 98,059448.2DCN, MMP3, MMP1, CHAT, BDNF, TIMP1
26matrigel448.2PDGFRB, BDNF, TIMP1, DCN, MMP1, CXCL10
27histamine44 28 2410.2BDNF, CHRM2, MMP3, TH, CXCL10, CNR1
28testosterone44 61 24 1111.1BDNF, NPY, MMP1, TNFRSF1A, TH, PDGFRB
29choline44 24 1110.1CHAT, TH, NPY, BDNF, SLC18A3, ACHE
30lactate448.1NPY, MMP3, CHAT, TIMP1, TH, BDNF
31indomethacin44 28 61 1111.1BDNF, NPY, CNR1, MMP3, TIMP1, TNFRSF1A
32cycloheximide448.0TNFRSF1A, BDNF, MMP1, MMP3, TIMP1, CHAT
33cholesterol44 28 24 1111.0TIMP1, BDNF, PDGFRB, CXCL10, TNFRSF1A, DCN
34dexamethasone44 50 28 1111.0MMP3, MMP1, TH, DCN, TIMP1, TNFRSF1A
35nitric oxide44 24 119.7TIMP1, NPY, TNFRSF1A, DCN, CHAT, CHRM2
36dopamine44 28 24 1110.7TH, CHAT, TNFRSF1A, ACHE, NPY, BDNF
37glucose447.7CNR1, BDNF, NPY, PDGFRB, SLC17A6, TNFRSF1A
38paraffin447.7DCN, MMP3, MMP1, NPY, TIMP1, CHAT
39norepinephrine44 24 119.6TH, TNFRSF1A, TIMP1, MMP1, CHRM2, NPY
40acetylcholine44 50 28 24 1111.6TH, SLC18A3, CHAT, MMP3, CHRM2, ACHE
41alanine447.5TNFRSF1A, CHAT, CHRM2, NPY, PDGFRB, CNR1
42vegf447.5TH, TNFRSF1A, TIMP1, BDNF, MMP3, MMP1
43calcium44 50 24 1110.4PDGFRB, CNR1, CHRM2, CXCL10, NPY, CHAT
44atp44 288.3PDGFRB, CXCL10, CHAT, MMP3, NPY, BDNF
45serine447.1ACHE, PDGFRB, CNR1, MMP1, MMP3, DCN
46cysteine447.0TH, TNFRSF1A, TIMP1, MMP1, MMP3, DCN
47tyrosine446.4MMP3, CHAT, DCN, TIMP1, TNFRSF1A, CHRM2
48retinoic acid44 247.2BDNF, NPY, PDGFRB, CXCL10, CHAT, MMP1
49glutamate446.0SLC17A6, TH, TNFRSF1A, TIMP1, DCN, MMP3
50estrogen445.9DCN, TH, TNFRSF1A, MMP1, CHAT, CHRM2

GO Terms for genes affiliated with Tendinosis

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Cellular components related to Tendinosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.5ACHE, CHAT, TNFRSF1A
2extracellular spaceGO:0056158.3TNFRSF1A, DCN, MMP3, CXCL10, ACHE, NPY
3extracellular regionGO:0055766.9BDNF, TNFRSF1A, TIMP1, DCN, MMP3, MMP1

Biological processes related to Tendinosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.9NPY, CNR1, CHRM2
2regulation of heart contractionGO:0080169.9CHRM2, TH
3response to hyperoxiaGO:0550939.8BDNF, PDGFRB
4muscle organ developmentGO:0075179.8CHAT, CXCL10, ACHE
5neurotransmitter biosynthetic processGO:0421369.8TH, CHAT, ACHE
6response to ethanolGO:0454719.7TH, TNFRSF1A, CNR1
7phosphatidylcholine biosynthetic processGO:0066569.5ACHE, CHAT
8agingGO:0075689.4TIMP1, DCN, CNR1
9response to lipopolysaccharideGO:0324969.3CNR1, CXCL10, DCN, TNFRSF1A, TH
10response to hypoxiaGO:0016669.2BDNF, TNFRSF1A, TH
11extracellular matrix disassemblyGO:0226179.0TIMP1, DCN, MMP3, MMP1
12extracellular matrix organizationGO:0301989.0TIMP1, DCN, MMP3, MMP1
13synaptic transmissionGO:0072688.7CHAT, ACHE, NPY, SLC18A3

Products for genes affiliated with Tendinosis

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Sources for Tendinosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet