MCID: TND006
MIFTS: 42

Tendinosis malady

Summaries for Tendinosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Tendinosis, sometimes called chronic tendinitis, chronic tendinopathy, or chronic tendon injury, is... more...

MalaCards: Tendinosis is related to tendinopathy and tendinitis. An important gene associated with Tendinosis is CHAT (choline O-acetyltransferase), and among its related pathways are Acetylcholine Synthesis and TNF signaling pathway. The compounds physostigmine and ibotenic acid have been mentioned in the context of this disorder. Affiliated tissues include bone and bone marrow, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Aliases & Classifications for Tendinosis

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34MalaCards
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Aliases & Descriptions:

tendinosis 34


Related Diseases for Tendinosis

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18GeneCards, 19GeneDecks
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Diseases related to Tendinosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1tendinopathy10.3
2tendinitis10.2
3bursitis10.2
4chronic pain10.2
5pigmented villonodular synovitis10.1PDGFRB
6fibromatosis10.1PDGFRB
7drug dependence10.1CNR1, CHRM2
8paracoccidioidomycosis10.1CXCL10, TNFRSF1A
9congenital myasthenic syndrome10.1CHAT, ACHE
10amnestic disorder10.1ACHE, CHAT
11ganglioneuroblastoma10.1NPY, TH
12neuroepithelioma10.1CHAT, NPY
13alcohol dependence10.1CNR1, CHRM2, NPY
14brain disease10.1CXCL10, TH, CHAT
15vascular dementia10.1CHAT, ACHE
16biliary atresia10.0TIMP1, CXCL10
17central hypoventilation syndrome, congenital, with or without hirschsprung disease10.0BDNF, TH
18neonatal hypoxic and ischemic brain injury10.0TH, BDNF
19osteoporosis10.0CNR1, MMP3, NPY
20bulimia nervosa10.0NPY, BDNF
21noonan syndrome10.0CNR1, CHRM2, TNFRSF1A
22congenital heart disease10.0CHRM2, MMP3, TNFRSF1A
23lewy body dementia10.0ACHE, TH
24localized scleroderma10.0DCN, MMP1
25central nervous system disease10.0CHAT, BDNF, CNR1
26kawasaki disease10.0TIMP1, MMP3
27progressive supranuclear palsy10.0TH, CHAT, ACHE
28epidermolysis bullosa dystrophica10.0MMP1, MMP3
29pheochromocytoma10.0CHAT, NPY, SLC18A3, TH
30status epilepticus10.0BDNF, NPY, CNR1
31ganglioneuroma10.0NPY, TH
32eating disorder10.0CNR1, BDNF, NPY
33anxiety disorder10.0CNR1, BDNF, NPY
34anorexia nervosa10.0CNR1, NPY, BDNF
35rett syndrome10.0BDNF, CHAT, TH
36neuroblastoma10.0TH, CHAT, BDNF
37astrocytoma10.0CNR1, PDGFRB, CXCL10, MMP3
38liver cirrhosis10.0NPY, TIMP1, CNR1
39primary hyperoxaluria10.0DCN, CXCL10, MMP3, NPY
40toxic encephalopathy10.0BDNF, CHAT, TH
41relapsing-remitting multiple sclerosis10.0TIMP1, BDNF
42neuronitis10.0
43calcific tendinitis10.0
44epicondylitis10.0
45galactosemia10.0NPY, CXCL10, CNR1, TNFRSF1A
46metabolic syndrome x10.0ACHE, NPY, CNR1
47viral infectious disease10.0CXCL10, MMP3, CHRM2, TNFRSF1A
48oral submucous fibrosis10.0MMP1, TIMP1
49parkinson's disease10.0BDNF, TH, CNR1
50cerebrovascular disease10.0CNR1, CHAT, TNFRSF1A, TH

Graphical network of the top 20 diseases related to Tendinosis:



Diseases related to tendinosis

Symptoms for Tendinosis

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Drugs & Therapeutics for Tendinosis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Tendinosis

Drug clinical trials:

Search ClinicalTrials for Tendinosis

Search NIH Clinical Center for Tendinosis

Search CenterWatch for Tendinosis

Genetic Tests for Tendinosis

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Anatomical Context for Tendinosis

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34MalaCards
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MalaCards organs/tissues related to Tendinosis:

34
Bone, Bone marrow

Animal Models for Tendinosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Tendinosis:

38 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7TNFRSF1A, DCN, CHRM2, PDGFRB, NPY
2MP:00053818.7TNFRSF1A, DCN, CNR1, PDGFRB, NPY, BDNF
3MP:00053758.5TNFRSF1A, ACHE, CNR1, PDGFRB, NPY, SLC17A6
4MP:00020068.4TH, TNFRSF1A, TIMP1, DCN, MMP1
5MP:00053918.3TH, TNFRSF1A, DCN, CHRM2, ACHE, PDGFRB
6MP:00028738.3TH, CHAT, CNR1, PDGFRB, NPY, BDNF
7MP:00053858.2TH, TNFRSF1A, TIMP1, CHAT, CHRM2, CXCL10
8MP:00053848.2BDNF, PDGFRB, CNR1, CXCL10, DCN, TNFRSF1A
9MP:00053698.0TNFRSF1A, DCN, CHAT, CHRM2, ACHE, PDGFRB
10MP:00107718.0TH, TNFRSF1A, DCN, CHRM2, CNR1, PDGFRB
11MP:00053978.0TNFRSF1A, TIMP1, DCN, MMP3, CXCL10, ACHE
12MP:00053907.9TNFRSF1A, DCN, MMP3, CHAT, CNR1, PDGFRB
13MP:00030127.8TH, ACHE, CNR1, BDNF, SLC18A3, SLC17A6
14MP:00053897.8TNFRSF1A, TIMP1, DCN, CHAT, ACHE, CNR1
15MP:00053877.8TNFRSF1A, TIMP1, DCN, MMP3, MMP1, CXCL10
16MP:00053887.5TH, TNFRSF1A, TIMP1, DCN, CHRM2, ACHE
17MP:00053866.6TH, TNFRSF1A, DCN, CHAT, CHRM2, ACHE
18MP:00053786.5CHAT, DCN, TIMP1, TNFRSF1A, TH, CHRM2
19MP:00036316.0TH, TNFRSF1A, MMP3, CHAT, CHRM2, CXCL10
20MP:00107685.9CHAT, DCN, TIMP1, TNFRSF1A, TH, CXCL10
21MP:00053764.6SLC17A6, TH, TNFRSF1A, TIMP1, DCN, MMP3

Publications for Tendinosis

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53PubMed
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Articles related to Tendinosis:

(show all 18)
idTitleAuthorsYear
1
Tendinopathy: why the difference between tendinitis and tendinosis matters. (22553479)
2012
2
Increased expression of cannabinoid CBa88 receptors in Achilles tendinosis. (21931835)
2011
3
Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors: a pilot study. (21819445)
2011
4
Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy-peptidergic elevation preceding tendinosis-like tissue changes. (21625050)
2011
5
VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes. (18050306)
2008
6
Autologous bone marrow plasma injection after arthroscopic debridement for elbow tendinosis. (18695767)
2008
7
Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy). (17999088)
2008
8
In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis. (17661370)
2007
9
Extensive expression of markers for acetylcholine synthesis and of M2 receptors in tenocytes in therapy-resistant chronic painful patellar tendon tendinosis - a pilot study. (17289083)
2007
10
Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man. (17206652)
2007
11
Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. (16830327)
2006
12
Tennis elbow tendinosis (epicondylitis). (15116648)
2004
13
cDNA-arrays and real-time quantitative PCR techniques in the investigation of chronic Achilles tendinosis. (14554207)
2003
14
Increased expression of matrix metalloproteinase 1 (MMP1) in 11 patients with patellar tendinosis. (12553513)
2002
15
Increased cell proliferation and associated expression of PDGFRbeta causing hypercellularity in patellar tendinosis. (11285371)
2001
16
Re: "Comparison of results of retrocalcaneal decompression for retrocalcaneal bursitis and insertional Achilles tendinosis with calcific spur" by Dr. Anthony Watson et. al. (11475463)
2001
17
Expression of transforming growth factor-beta isoforms and their receptors in chronic tendinosis. (11554502)
2001
18
Comparison of results of retrocalcaneal decompression for retrocalcaneal bursitis and insertional achilles tendinosis with calcific spur. (10966360)
2000

Variations for Tendinosis

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Expression for genes affiliated with Tendinosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tendinosis

Search GEO for disease gene expression data for Tendinosis.

Pathways for genes affiliated with Tendinosis

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 56Reactome, 61Thomson Reuters, 13EMD Millipore, 54QIAGEN, 52PharmGKB
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Pathways related to Tendinosis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CHAT, ACHE
29.6CXCL10, MMP3, TNFRSF1A
3
Show member pathways
catecholamine biosynthesis39
9.5TH, ACHE, CHAT
49.3MMP1, TIMP1
59.2BDNF, ACHE, TNFRSF1A
69.2TH, CHAT, BDNF, CHRM2
7
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.0MMP1, MMP3, TIMP1
8
Show member pathways
9.0MMP1, MMP3, TIMP1
9
Show member pathways
9.0MMP3, MMP1, TIMP1
10
Show member pathways
8.8MMP3, CNR1, CHRM2, CXCL10, PDGFRB, NPY
11
Show member pathways
8.8MMP1, MMP3, DCN, TIMP1
12
Show member pathways
8.7TIMP1, BDNF, TH, PDGFRB
13
Show member pathways
8.7BDNF, PDGFRB, TIMP1, TNFRSF1A
148.7SLC18A3, TH, CHAT, ACHE
15
Show member pathways
8.5TIMP1, CXCL10, PDGFRB, BDNF, TNFRSF1A
16
Show member pathways
8.5CXCL10, BDNF, TNFRSF1A, TIMP1, PDGFRB
17
Show member pathways
8.5PDGFRB, TIMP1, BDNF, CXCL10, TNFRSF1A
18
Show member pathways
8.5TNFRSF1A, TIMP1, CXCL10, PDGFRB, BDNF
19
Show member pathways
8.3MMP3, TIMP1, PDGFRB, MMP1, BDNF
20
Show member pathways
7.7SLC18A3, CHAT, CNR1, ACHE, CHRM2, TH

Compounds for genes affiliated with Tendinosis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 3BitterDB, 62Tocris Bioscience, 25HMDB
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Compounds related to Tendinosis according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1physostigmine46 1210.7ACHE, CNR1, CHRM2, CHAT
2ibotenic acid469.5TH, CHAT, NPY
3desipramine46 52 1211.2BDNF, CNR1, TH, CHRM2
4kainate46 3010.2CHAT, BDNF, NPY, CNR1, TH
55-hydroxytryptamine469.1CHRM2, CHAT, TH, NPY, CNR1
6hydroxamate469.0MMP1, MMP3, TIMP1, TNFRSF1A
7haloperidol46 52 30 3 1212.9TH, CHAT, BDNF, NPY, MMP1
8tetrodotoxin46 62 3010.9TH, CHRM2, BDNF, ACHE, CNR1, NPY
9carbachol46 30 1210.8CHRM2, TH, ACHE, CNR1, NPY, BDNF
10infliximab46 52 1210.8MMP1, MMP3, CXCL10, TNFRSF1A, TIMP1
11glycosaminoglycan468.8MMP1, DCN, CXCL10, TIMP1, MMP3
12leflunomide46 52 1210.8PDGFRB, MMP1, TNFRSF1A, MMP3, TIMP1
13nicotine46 30 52 1211.6CNR1, CHAT, CHRM2, ACHE, NPY, MMP1
14nmda46 309.6BDNF, NPY, CNR1, CHAT, TH, ACHE
15gaba468.5CNR1, CHRM2, CHAT, BDNF, NPY, TH
16tgf beta1468.5PDGFRB, MMP3, DCN, TIMP1, TNFRSF1A, MMP1
17forskolin46 52 1210.4CHRM2, NPY, CXCL10, BDNF, MMP3, TNFRSF1A
18cyclic amp46 259.4BDNF, CXCL10, CNR1, CHRM2, CHAT, TNFRSF1A
19ribonucleic acid468.4TIMP1, MMP3, DCN, TNFRSF1A, PDGFRB, MMP1
20etanercept46 52 1210.4MMP3, TIMP1, TNFRSF1A, MMP1
21creatinine468.4MMP1, NPY, CXCL10, TNFRSF1A, DCN, MMP3
22adenylate468.3TH, CXCL10, BDNF, NPY, TIMP1, CHRM2
23cocaine46 129.3SLC18A3, CHRM2, TH, CHAT, CNR1, NPY
24aspartate468.2BDNF, CNR1, CHAT, DCN, TNFRSF1A, TIMP1
25pd 98,059468.2DCN, MMP3, MMP1, CHAT, BDNF, TIMP1
26matrigel468.2PDGFRB, BDNF, TIMP1, DCN, MMP1, CXCL10
27histamine46 30 2510.2BDNF, CHRM2, MMP3, TH, CXCL10, CNR1
28testosterone46 62 25 1211.1BDNF, NPY, MMP1, TNFRSF1A, TH, PDGFRB
29choline46 25 1210.1CHAT, TH, NPY, BDNF, SLC18A3, ACHE
30lactate468.1NPY, MMP3, CHAT, TIMP1, TH, BDNF
31indomethacin46 30 62 1211.1BDNF, NPY, CNR1, MMP3, TIMP1, TNFRSF1A
32cycloheximide468.0TNFRSF1A, BDNF, MMP1, MMP3, TIMP1, CHAT
33cholesterol46 30 25 1211.0TIMP1, BDNF, PDGFRB, CXCL10, TNFRSF1A, DCN
34dexamethasone46 52 30 1211.0MMP3, MMP1, TH, DCN, TIMP1, TNFRSF1A
35nitric oxide46 25 129.7TIMP1, NPY, TNFRSF1A, DCN, CHAT, CHRM2
36dopamine46 30 25 1210.7TH, CHAT, TNFRSF1A, ACHE, NPY, BDNF
37glucose467.7CNR1, BDNF, NPY, PDGFRB, SLC17A6, TNFRSF1A
38paraffin467.7DCN, MMP3, MMP1, NPY, TIMP1, CHAT
39norepinephrine46 25 129.6TH, TNFRSF1A, TIMP1, MMP1, CHRM2, NPY
40acetylcholine46 52 30 25 1211.6TH, SLC18A3, CHAT, MMP3, CHRM2, ACHE
41alanine467.5TNFRSF1A, CHAT, CHRM2, NPY, PDGFRB, CNR1
42vegf467.5TH, TNFRSF1A, TIMP1, BDNF, MMP3, MMP1
43calcium46 52 25 1210.4PDGFRB, CNR1, CHRM2, CXCL10, NPY, CHAT
44atp46 308.3PDGFRB, CXCL10, CHAT, MMP3, NPY, BDNF
45serine467.1ACHE, PDGFRB, CNR1, MMP1, MMP3, DCN
46cysteine467.0TH, TNFRSF1A, TIMP1, MMP1, MMP3, DCN
47tyrosine466.4MMP3, CHAT, DCN, TIMP1, TNFRSF1A, CHRM2
48retinoic acid46 257.2BDNF, NPY, PDGFRB, CXCL10, CHAT, MMP1
49glutamate466.0SLC17A6, TH, TNFRSF1A, TIMP1, DCN, MMP3
50estrogen465.9DCN, TH, TNFRSF1A, MMP1, CHAT, CHRM2

GO Terms for genes affiliated with Tendinosis

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17Gene Ontology
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Cellular components related to Tendinosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.5ACHE, CHAT, TNFRSF1A
2extracellular spaceGO:0056158.3TNFRSF1A, DCN, MMP3, CXCL10, ACHE, NPY
3extracellular regionGO:0055766.9BDNF, TNFRSF1A, TIMP1, DCN, MMP3, MMP1

Biological processes related to Tendinosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.9NPY, CNR1, CHRM2
2regulation of heart contractionGO:0080169.9CHRM2, TH
3response to hyperoxiaGO:0550939.8BDNF, PDGFRB
4muscle organ developmentGO:0075179.8CHAT, CXCL10, ACHE
5neurotransmitter biosynthetic processGO:0421369.8TH, CHAT, ACHE
6response to ethanolGO:0454719.7TH, TNFRSF1A, CNR1
7phosphatidylcholine biosynthetic processGO:0066569.5ACHE, CHAT
8agingGO:0075689.4TIMP1, DCN, CNR1
9response to lipopolysaccharideGO:0324969.3CNR1, CXCL10, DCN, TNFRSF1A, TH
10response to hypoxiaGO:0016669.2BDNF, TNFRSF1A, TH
11extracellular matrix disassemblyGO:0226179.0TIMP1, DCN, MMP3, MMP1
12extracellular matrix organizationGO:0301989.0TIMP1, DCN, MMP3, MMP1
13synaptic transmissionGO:0072688.7CHAT, ACHE, NPY, SLC18A3

Products for genes affiliated with Tendinosis

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  • Antibodies
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Sources for Tendinosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet