MCID: TND006
MIFTS: 42

Tendinosis malady

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Summaries for Tendinosis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Tendinosis, sometimes called chronic tendinitis, chronic tendinopathy, or chronic tendon injury, is... more...

MalaCards: Tendinosis is related to tendinopathy and tendinitis. An important gene associated with Tendinosis is CHAT (choline O-acetyltransferase), and among its related pathways are Acetylcholine Synthesis and TNF signaling pathway. The compounds physostigmine and ibotenic acid have been mentioned in the context of this disorder. Affiliated tissues include bone and bone marrow, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Aliases & Classifications for Tendinosis

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33MalaCards
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Aliases & Descriptions:

tendinosis 33


Related Diseases for Tendinosis

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17GeneCards, 18GeneDecks
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Diseases related to Tendinosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1tendinopathy10.3
2tendinitis10.2
3bursitis10.2
4chronic pain10.2
5pigmented villonodular synovitis10.1PDGFRB
6fibromatosis10.1PDGFRB
7drug dependence10.1CNR1, CHRM2
8paracoccidioidomycosis10.1CXCL10, TNFRSF1A
9congenital myasthenic syndrome10.1CHAT, ACHE
10amnestic disorder10.1ACHE, CHAT
11ganglioneuroblastoma10.1NPY, TH
12neuroepithelioma10.1CHAT, NPY
13alcohol dependence10.1CNR1, CHRM2, NPY
14brain disease10.1CXCL10, TH, CHAT
15vascular dementia10.1CHAT, ACHE
16biliary atresia10.0TIMP1, CXCL10
17central hypoventilation syndrome, congenital, with or without hirschsprung disease10.0BDNF, TH
18neonatal hypoxic and ischemic brain injury10.0TH, BDNF
19osteoporosis10.0CNR1, MMP3, NPY
20bulimia nervosa10.0NPY, BDNF
21noonan syndrome10.0CNR1, CHRM2, TNFRSF1A
22congenital heart disease10.0CHRM2, MMP3, TNFRSF1A
23lewy body dementia10.0ACHE, TH
24localized scleroderma10.0DCN, MMP1
25central nervous system disease10.0CHAT, BDNF, CNR1
26kawasaki disease10.0TIMP1, MMP3
27progressive supranuclear palsy10.0TH, CHAT, ACHE
28epidermolysis bullosa dystrophica10.0MMP1, MMP3
29pheochromocytoma10.0CHAT, NPY, SLC18A3, TH
30status epilepticus10.0BDNF, NPY, CNR1
31ganglioneuroma10.0NPY, TH
32eating disorder10.0CNR1, BDNF, NPY
33anxiety disorder10.0CNR1, BDNF, NPY
34anorexia nervosa10.0CNR1, NPY, BDNF
35rett syndrome10.0BDNF, CHAT, TH
36neuroblastoma10.0TH, CHAT, BDNF
37astrocytoma10.0CNR1, PDGFRB, CXCL10, MMP3
38liver cirrhosis10.0NPY, TIMP1, CNR1
39primary hyperoxaluria10.0DCN, CXCL10, MMP3, NPY
40toxic encephalopathy10.0BDNF, CHAT, TH
41relapsing-remitting multiple sclerosis10.0TIMP1, BDNF
42neuronitis10.0
43calcific tendinitis10.0
44epicondylitis10.0
45galactosemia10.0NPY, CXCL10, CNR1, TNFRSF1A
46metabolic syndrome x10.0ACHE, NPY, CNR1
47viral infectious disease10.0CXCL10, MMP3, CHRM2, TNFRSF1A
48oral submucous fibrosis10.0MMP1, TIMP1
49parkinson's disease10.0BDNF, TH, CNR1
50cerebrovascular disease10.0CNR1, CHAT, TNFRSF1A, TH

Graphical network of the top 20 diseases related to Tendinosis:



Diseases related to tendinosis

Symptoms for Tendinosis

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Drugs & Therapeutics for Tendinosis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Tendinosis

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Anatomical Context for Tendinosis

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33MalaCards
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MalaCards organs/tissues related to Tendinosis:

33
Bone, Bone marrow

Animal Models for Tendinosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Tendinosis:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7TNFRSF1A, DCN, CHRM2, PDGFRB, NPY
2MP:00053818.7TNFRSF1A, DCN, CNR1, PDGFRB, NPY, BDNF
3MP:00053758.5TNFRSF1A, ACHE, CNR1, PDGFRB, NPY, SLC17A6
4MP:00020068.4TH, TNFRSF1A, TIMP1, DCN, MMP1
5MP:00053918.3TH, TNFRSF1A, DCN, CHRM2, ACHE, PDGFRB
6MP:00028738.3TH, CHAT, CNR1, PDGFRB, NPY, BDNF
7MP:00053858.2TH, TNFRSF1A, TIMP1, CHAT, CHRM2, CXCL10
8MP:00053848.2BDNF, PDGFRB, CNR1, CXCL10, DCN, TNFRSF1A
9MP:00053698.0TNFRSF1A, DCN, CHAT, CHRM2, ACHE, PDGFRB
10MP:00107718.0TH, TNFRSF1A, DCN, CHRM2, CNR1, PDGFRB
11MP:00053978.0TNFRSF1A, TIMP1, DCN, MMP3, CXCL10, ACHE
12MP:00053907.9TNFRSF1A, DCN, MMP3, CHAT, CNR1, PDGFRB
13MP:00030127.8TH, ACHE, CNR1, BDNF, SLC18A3, SLC17A6
14MP:00053897.8TNFRSF1A, TIMP1, DCN, CHAT, ACHE, CNR1
15MP:00053877.8TNFRSF1A, TIMP1, DCN, MMP3, MMP1, CXCL10
16MP:00053887.5TH, TNFRSF1A, TIMP1, DCN, CHRM2, ACHE
17MP:00053866.6TH, TNFRSF1A, DCN, CHAT, CHRM2, ACHE
18MP:00053786.5CHAT, DCN, TIMP1, TNFRSF1A, TH, CHRM2
19MP:00036316.0TH, TNFRSF1A, MMP3, CHAT, CHRM2, CXCL10
20MP:00107685.9CHAT, DCN, TIMP1, TNFRSF1A, TH, CXCL10
21MP:00053764.6SLC17A6, TH, TNFRSF1A, TIMP1, DCN, MMP3

Publications for Tendinosis

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52PubMed
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Articles related to Tendinosis:

(show all 18)
idTitleAuthorsYear
1
Tendinopathy: why the difference between tendinitis and tendinosis matters. (22553479)
2012
2
Increased expression of cannabinoid CBa88 receptors in Achilles tendinosis. (21931835)
2011
3
Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors: a pilot study. (21819445)
2011
4
Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy-peptidergic elevation preceding tendinosis-like tissue changes. (21625050)
2011
5
VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes. (18050306)
2008
6
Autologous bone marrow plasma injection after arthroscopic debridement for elbow tendinosis. (18695767)
2008
7
Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy). (17999088)
2008
8
In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis. (17661370)
2007
9
Extensive expression of markers for acetylcholine synthesis and of M2 receptors in tenocytes in therapy-resistant chronic painful patellar tendon tendinosis - a pilot study. (17289083)
2007
10
Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man. (17206652)
2007
11
Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. (16830327)
2006
12
Tennis elbow tendinosis (epicondylitis). (15116648)
2004
13
cDNA-arrays and real-time quantitative PCR techniques in the investigation of chronic Achilles tendinosis. (14554207)
2003
14
Increased expression of matrix metalloproteinase 1 (MMP1) in 11 patients with patellar tendinosis. (12553513)
2002
15
Increased cell proliferation and associated expression of PDGFRbeta causing hypercellularity in patellar tendinosis. (11285371)
2001
16
Re: "Comparison of results of retrocalcaneal decompression for retrocalcaneal bursitis and insertional Achilles tendinosis with calcific spur" by Dr. Anthony Watson et. al. (11475463)
2001
17
Expression of transforming growth factor-beta isoforms and their receptors in chronic tendinosis. (11554502)
2001
18
Comparison of results of retrocalcaneal decompression for retrocalcaneal bursitis and insertional achilles tendinosis with calcific spur. (10966360)
2000

Variations for Tendinosis

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Expression for genes affiliated with Tendinosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tendinosis

Search GEO for disease gene expression data for Tendinosis.

Pathways for genes affiliated with Tendinosis

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50PathCards, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 60Thomson Reuters, 12EMD Millipore, 53QIAGEN, 51PharmGKB
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Pathways related to Tendinosis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CHAT, ACHE
29.6CXCL10, MMP3, TNFRSF1A
3
Show member pathways
catecholamine biosynthesis38
9.5TH, ACHE, CHAT
49.3MMP1, TIMP1
59.2BDNF, ACHE, TNFRSF1A
69.2TH, CHAT, BDNF, CHRM2
7
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
9.0MMP1, MMP3, TIMP1
8
Show member pathways
9.0MMP1, MMP3, TIMP1
9
Show member pathways
9.0MMP3, MMP1, TIMP1
10
Show member pathways
8.8MMP3, CNR1, CHRM2, CXCL10, PDGFRB, NPY
11
Show member pathways
8.8MMP1, MMP3, DCN, TIMP1
12
Show member pathways
8.7TIMP1, BDNF, TH, PDGFRB
13
Show member pathways
8.7BDNF, PDGFRB, TIMP1, TNFRSF1A
148.7SLC18A3, TH, CHAT, ACHE
15
Show member pathways
8.5TIMP1, CXCL10, PDGFRB, BDNF, TNFRSF1A
16
Show member pathways
8.5CXCL10, BDNF, TNFRSF1A, TIMP1, PDGFRB
17
Show member pathways
8.5PDGFRB, TIMP1, BDNF, CXCL10, TNFRSF1A
18
Show member pathways
8.5TNFRSF1A, TIMP1, CXCL10, PDGFRB, BDNF
19
Show member pathways
8.3MMP3, TIMP1, PDGFRB, MMP1, BDNF
20
Show member pathways
7.7SLC18A3, CHAT, CNR1, ACHE, CHRM2, TH

Compounds for genes affiliated with Tendinosis

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45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 3BitterDB, 61Tocris Bioscience, 24HMDB
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Compounds related to Tendinosis according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1physostigmine45 1110.7ACHE, CNR1, CHRM2, CHAT
2ibotenic acid459.5TH, CHAT, NPY
3desipramine45 51 1111.2BDNF, CNR1, TH, CHRM2
4kainate45 2910.2CHAT, BDNF, NPY, CNR1, TH
55-hydroxytryptamine459.1CHRM2, CHAT, TH, NPY, CNR1
6hydroxamate459.0MMP1, MMP3, TIMP1, TNFRSF1A
7haloperidol45 51 29 3 1112.9TH, CHAT, BDNF, NPY, MMP1
8tetrodotoxin45 61 2910.9TH, CHRM2, BDNF, ACHE, CNR1, NPY
9carbachol45 29 1110.8CHRM2, TH, ACHE, CNR1, NPY, BDNF
10infliximab45 51 1110.8MMP1, MMP3, CXCL10, TNFRSF1A, TIMP1
11glycosaminoglycan458.8MMP1, DCN, CXCL10, TIMP1, MMP3
12leflunomide45 51 1110.8PDGFRB, MMP1, TNFRSF1A, MMP3, TIMP1
13nicotine45 29 51 1111.6CNR1, CHAT, CHRM2, ACHE, NPY, MMP1
14nmda45 299.6BDNF, NPY, CNR1, CHAT, TH, ACHE
15gaba458.5CNR1, CHRM2, CHAT, BDNF, NPY, TH
16tgf beta1458.5PDGFRB, MMP3, DCN, TIMP1, TNFRSF1A, MMP1
17forskolin45 51 1110.4CHRM2, NPY, CXCL10, BDNF, MMP3, TNFRSF1A
18cyclic amp45 249.4BDNF, CXCL10, CNR1, CHRM2, CHAT, TNFRSF1A
19ribonucleic acid458.4TIMP1, MMP3, DCN, TNFRSF1A, PDGFRB, MMP1
20etanercept45 51 1110.4MMP3, TIMP1, TNFRSF1A, MMP1
21creatinine458.4MMP1, NPY, CXCL10, TNFRSF1A, DCN, MMP3
22adenylate458.3TH, CXCL10, BDNF, NPY, TIMP1, CHRM2
23cocaine45 119.3SLC18A3, CHRM2, TH, CHAT, CNR1, NPY
24aspartate458.2BDNF, CNR1, CHAT, DCN, TNFRSF1A, TIMP1
25pd 98,059458.2DCN, MMP3, MMP1, CHAT, BDNF, TIMP1
26matrigel458.2PDGFRB, BDNF, TIMP1, DCN, MMP1, CXCL10
27histamine45 29 2410.2BDNF, CHRM2, MMP3, TH, CXCL10, CNR1
28testosterone45 61 24 1111.1BDNF, NPY, MMP1, TNFRSF1A, TH, PDGFRB
29choline45 24 1110.1CHAT, TH, NPY, BDNF, SLC18A3, ACHE
30lactate458.1NPY, MMP3, CHAT, TIMP1, TH, BDNF
31indomethacin45 29 61 1111.1BDNF, NPY, CNR1, MMP3, TIMP1, TNFRSF1A
32cycloheximide458.0TNFRSF1A, BDNF, MMP1, MMP3, TIMP1, CHAT
33cholesterol45 29 24 1111.0TIMP1, BDNF, PDGFRB, CXCL10, TNFRSF1A, DCN
34dexamethasone45 51 29 1111.0MMP3, MMP1, TH, DCN, TIMP1, TNFRSF1A
35nitric oxide45 24 119.7TIMP1, NPY, TNFRSF1A, DCN, CHAT, CHRM2
36dopamine45 29 24 1110.7TH, CHAT, TNFRSF1A, ACHE, NPY, BDNF
37glucose457.7CNR1, BDNF, NPY, PDGFRB, SLC17A6, TNFRSF1A
38paraffin457.7DCN, MMP3, MMP1, NPY, TIMP1, CHAT
39norepinephrine45 24 119.6TH, TNFRSF1A, TIMP1, MMP1, CHRM2, NPY
40acetylcholine45 51 29 24 1111.6TH, SLC18A3, CHAT, MMP3, CHRM2, ACHE
41alanine457.5TNFRSF1A, CHAT, CHRM2, NPY, PDGFRB, CNR1
42vegf457.5TH, TNFRSF1A, TIMP1, BDNF, MMP3, MMP1
43calcium45 51 24 1110.4PDGFRB, CNR1, CHRM2, CXCL10, NPY, CHAT
44atp45 298.3PDGFRB, CXCL10, CHAT, MMP3, NPY, BDNF
45serine457.1ACHE, PDGFRB, CNR1, MMP1, MMP3, DCN
46cysteine457.0TH, TNFRSF1A, TIMP1, MMP1, MMP3, DCN
47tyrosine456.4MMP3, CHAT, DCN, TIMP1, TNFRSF1A, CHRM2
48retinoic acid45 247.2BDNF, NPY, PDGFRB, CXCL10, CHAT, MMP1
49glutamate456.0SLC17A6, TH, TNFRSF1A, TIMP1, DCN, MMP3
50estrogen455.9DCN, TH, TNFRSF1A, MMP1, CHAT, CHRM2

GO Terms for genes affiliated with Tendinosis

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16Gene Ontology
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Cellular components related to Tendinosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.5ACHE, CHAT, TNFRSF1A
2extracellular spaceGO:0056158.3TNFRSF1A, DCN, MMP3, CXCL10, ACHE, NPY
3extracellular regionGO:0055766.9BDNF, TNFRSF1A, TIMP1, DCN, MMP3, MMP1

Biological processes related to Tendinosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.9NPY, CNR1, CHRM2
2regulation of heart contractionGO:0080169.9CHRM2, TH
3response to hyperoxiaGO:0550939.8BDNF, PDGFRB
4muscle organ developmentGO:0075179.8CHAT, CXCL10, ACHE
5neurotransmitter biosynthetic processGO:0421369.8TH, CHAT, ACHE
6response to ethanolGO:0454719.7TH, TNFRSF1A, CNR1
7phosphatidylcholine biosynthetic processGO:0066569.5ACHE, CHAT
8agingGO:0075689.4TIMP1, DCN, CNR1
9response to lipopolysaccharideGO:0324969.3CNR1, CXCL10, DCN, TNFRSF1A, TH
10response to hypoxiaGO:0016669.2BDNF, TNFRSF1A, TH
11extracellular matrix disassemblyGO:0226179.0TIMP1, DCN, MMP3, MMP1
12extracellular matrix organizationGO:0301989.0TIMP1, DCN, MMP3, MMP1
13synaptic transmissionGO:0072688.7CHAT, ACHE, NPY, SLC18A3

Products for genes affiliated with Tendinosis

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Sources for Tendinosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet