Aliases & Classifications for Tendinosis

Aliases & Descriptions for Tendinosis:

Name: Tendinosis 39 38 69

Summaries for Tendinosis

MalaCards based summary : Tendinosis is related to tendinitis and symmastia. An important gene associated with Tendinosis is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are PAK Pathway and Degradation of the extracellular matrix. The drugs Lidocaine and Menthol have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related phenotypes are homeostasis/metabolism and behavior/neurological

Wikipedia : 71 Tendinosis, sometimes called chronic tendinitis, chronic tendinopathy, or chronic tendon injury, is... more...

Related Diseases for Tendinosis

Graphical network of the top 20 diseases related to Tendinosis:



Diseases related to Tendinosis

Symptoms & Phenotypes for Tendinosis

MGI Mouse Phenotypes related to Tendinosis:

44 (show all 19)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.46 ACHE BDNF CHAT CHRM2 CNR1 CXCL10
2 behavior/neurological MP:0005386 10.39 ACHE BDNF CHAT CHRM2 CNR1 DCN
3 growth/size/body region MP:0005378 10.37 TGFB2 TGFBR2 TH ACHE BDNF CHAT
4 mortality/aging MP:0010768 10.32 ACHE BDNF CXCL10 DCN PDGFRB SLC17A6
5 nervous system MP:0003631 10.28 MMP3 NPY PDGFRB SLC17A6 SLC18A3 TGFB2
6 cardiovascular system MP:0005385 10.22 CHAT CHRM2 CXCL10 PDGFRB TGFB2 TGFBR2
7 digestive/alimentary MP:0005381 10.2 BDNF CHAT CNR1 DCN NPY PDGFRB
8 endocrine/exocrine gland MP:0005379 10.14 BDNF DCN PDGFRB TGFB2 TGFBR2 TH
9 adipose tissue MP:0005375 10.13 ACHE CNR1 NPY PDGFRB SLC17A6 TGFBR2
10 muscle MP:0005369 10.11 ACHE CHAT CHRM2 DCN PDGFRB SLC18A3
11 craniofacial MP:0005382 10.1 ACHE BDNF DCN PDGFRB TGFB2 TGFBR2
12 integument MP:0010771 10.1 BDNF CHRM2 CNR1 DCN PDGFRB SLC17A6
13 normal MP:0002873 9.97 BDNF CHAT CNR1 DCN NPY PDGFRB
14 neoplasm MP:0002006 9.91 DCN MMP1 TGFBR2 TH TIMP1 TNFRSF1A
15 no phenotypic analysis MP:0003012 9.91 ACHE BDNF CNR1 SLC17A6 TNFRSF1A SLC18A3
16 reproductive system MP:0005389 9.91 CHAT CNR1 DCN PDGFRB TGFB2 TIMP1
17 respiratory system MP:0005388 9.9 ACHE BDNF CHAT CHRM2 DCN SLC17A6
18 skeleton MP:0005390 9.7 NPY PDGFRB SLC18A3 TGFB2 TGFBR2 TIMP1
19 vision/eye MP:0005391 9.32 ACHE BDNF CHAT CHRM2 DCN PDGFRB

Drugs & Therapeutics for Tendinosis

Drugs for Tendinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 1,Phase 2 137-58-6 3676
2
Menthol Approved Phase 4 2216-51-5 16666
3 Anesthetics Phase 4,Phase 1,Phase 2
4 Anesthetics, Local Phase 4,Phase 1,Phase 2
5 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3
6
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
7
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
8
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
9
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741 24759
10 Prednisolone acetate Phase 2, Phase 3
11 Thrombin Phase 2, Phase 3
12 glucocorticoids Phase 2, Phase 3
13 Gastrointestinal Agents Phase 2, Phase 3
14 Neuroprotective Agents Phase 2, Phase 3
15 Hormone Antagonists Phase 2, Phase 3
16 Hormones Phase 2, Phase 3
17 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
19 Prednisolone hemisuccinate Phase 2, Phase 3
20 Prednisolone phosphate Phase 2, Phase 3
21 Protective Agents Phase 2, Phase 3
22 Antiemetics Phase 2, Phase 3
23 Anti-Inflammatory Agents Phase 2, Phase 3
24 Methylprednisolone acetate Phase 2, Phase 3
25 Methylprednisolone Hemisuccinate Phase 2, Phase 3
26 Autonomic Agents Phase 2, Phase 3
27 Antineoplastic Agents, Hormonal Phase 2, Phase 3
28 Calamus Nutraceutical Phase 2, Phase 3
29
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
30
Benzocaine Approved Phase 2 1994-09-7, 94-09-7 2337
31 tannic acid Approved, Nutraceutical Phase 2
32 Sodium Channel Blockers Phase 1, Phase 2
33 Diuretics, Potassium Sparing Phase 1, Phase 2
34 Anti-Arrhythmia Agents Phase 1, Phase 2
35 Central Nervous System Depressants Phase 1, Phase 2
36 triamcinolone acetonide Phase 2
37 Triamcinolone diacetate Phase 2
38 Triamcinolone hexacetonide Phase 2
39 Immunosuppressive Agents Phase 2
40 Mitogens
41 Performance-Enhancing Substances
42 Calcium, Dietary

Interventional clinical trials:

(show all 29)
id Name Status NCT ID Phase
1 Achilles Tendinosis Study; Comparison of Radiofrequency to Surgical MicroDebridement Completed NCT00534781 Phase 4
2 Radio-frequency (RF)-Based Plasma Micro-tenotomy for the Treatment of Shoulder Impingement Syndrome Completed NCT01554670 Phase 4
3 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
4 Bundang Rehabilitative Impact Study of the Elbow Epicondylitis Completed NCT02492945 Phase 4
5 Platelet-rich Plasma vs. Whole Blood for Gluteus Medius Tendinopathy Recruiting NCT02978833 Phase 4
6 Clinical Evaluation of Placement of Radiofrequency-based Plasma Microdebridement in the Treatment Algorithm for Foot and Ankle Tendinosis and Plantar Fasciosis Withdrawn NCT00420875 Phase 4
7 Subacromial Decompression Versus Subacromial Bursectomy for Patients With Rotator Cuff Tendinosis Unknown status NCT00196573 Phase 3
8 A Randomized Control Trial to Evaluate the Efficacy of Autologous Blood Injection Versus Local Corticosteroid Injection for Treatment of Lateral Epicondylitis Completed NCT00947765 Phase 2, Phase 3
9 Impact of Autologous Platelet Rich Plasma on Healing of Rotator Cuff Repairs Completed NCT01000935 Phase 2, Phase 3
10 Hyaluronate Injection for Lateral Epicondylitis Recruiting NCT02258295 Phase 3
11 A Dynamic Elastic Garment (DEG) in Patients With Rotator Cuff Tendinopathy Not yet recruiting NCT03032432 Phase 3
12 A Prospective Comparison of Ultrasound-Guided Percutaneous Platelet-Rich Plasma Injection Completed NCT01600326 Phase 2
13 Effectiveness of Dextrose Injection for Osgood-Schlatter Disease Completed NCT01300754 Phase 1, Phase 2
14 PEAK Platelet Rich Plasma Injection Treatment for Chronic Lateral Epicondylosis Recruiting NCT03072381 Phase 2
15 Safety and Efficacy of RCT-01 in Men and Women With Unilateral, Chronic Achilles Tendinosis Active, not recruiting NCT02330146 Phase 1, Phase 2
16 Platelet-Rich Plasma (PRP) Injection for the Treatment of Chronic Patellar Tendinopathy Enrolling by invitation NCT01843504 Phase 2
17 Radiofrequency Microtenotomy for Treatment of Rotator Cuff Tendinopathy Completed NCT02275689 Phase 1
18 Exercise and Shoe Orthoses in Treatment of Posterior Tibial Tendon Dysfunction Completed NCT00279630 Phase 1
19 Long Duration Therapeutic Ultrasound for Tendon Healing Completed NCT02466308
20 Steroid Versus Platelet Rich Plasma Injection for Chronic Low Back Pain Completed NCT02334475
21 Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injections Completed NCT01200875
22 Effects of Hypertonic Dextrose Water Injection for Supraspinatus Tendinosis Patients Recruiting NCT03000205
23 Percutaneous Needle Tenotomy (PNT) Versus Platelet Rich Plasma (PRP) With PNT in the Treatment of Chronic Tendinosis Recruiting NCT01833598
24 Treatment of Acute and Chronic Ligament and Tendon Injuries With Platelet Rich Plasma Recruiting NCT01406821
25 Cellular & Biocellular Regenerative Therapy in Musculoskeletal Pain, Dysfunction,Degenerative or Inflammatory Disease Recruiting NCT03090672
26 Physiotherapy or Acupuncture for Lateral Epicondylitis Recruiting NCT02321696
27 Effectiveness of Isometric vs. Eccentric Exercise in Chronic Achilles Tendinopathy Recruiting NCT02732782
28 Effects of Isoinertial Training on Rotator Cuff Tendinopathy Not yet recruiting NCT02982460
29 Long-Term Follow-up of the Safety and Efficacy of RCT-01 in Men and Women With Unilateral, Chronic Achilles Tendinosis Withdrawn NCT02655042

Search NIH Clinical Center for Tendinosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Tendinosis cell therapies at LifeMap Discovery.

Genetic Tests for Tendinosis

Anatomical Context for Tendinosis

MalaCards organs/tissues related to Tendinosis:

39
Skin, Bone, Bone Marrow

Publications for Tendinosis

Articles related to Tendinosis:

(show top 50) (show all 62)
id Title Authors Year
1
Greater Trochanteric Pain Syndrome: Percutaneous Tendon Fenestration Versus Platelet-Rich Plasma Injection for Treatment of Gluteal Tendinosis. ( 27663654 )
2016
2
Return to Sport and Physical Activity After Calcaneoplasty for Insertional Achilles Tendinosis. ( 27600485 )
2016
3
CORR Insights(Ar): Corticosteroid Injections Give Small and Transient Pain Relief in Rotator Cuff Tendinosis: A Meta-analysis. ( 27572298 )
2016
4
T2 * relaxation time in Achilles tendinosis and controls and its correlation with clinical score. ( 26605756 )
2016
5
Comparison of Clinical Efficacy Among Endoscopy-Assisted Radio-Frequency Ablation, Extracorporeal Shockwaves, and Eccentric Exercises in Treatment of Insertional Achilles Tendinosis. ( 27723374 )
2016
6
Technical Innovation Case Report: Ultrasound-Guided Prolotherapy Injection for Insertional Achilles Calcific Tendinosis. ( 27974984 )
2016
7
Corticosteroid Injections Give Small and Transient Pain Relief in Rotator Cuff Tendinosis: A Meta-analysis. ( 27469590 )
2016
8
Efficacy of Achilles Suture Bridge Technique for Insertional Achilles Tendinosis in an Obese and Athletic Patient. ( 27644578 )
2016
9
High Power Laser for Treatment of Achilles Tendinosis - a Single Blind Randomized Placebo Controlled Clinical Study. ( 27330704 )
2016
10
The molecular systemic and local effects of intra-tendinous injection of Platelet Rich Plasma in tendinosis: preliminary results on a rat model with ELISA method. ( 26261788 )
2015
11
Results of Surgical Treatment of Chronic Patellar Tendinosis (Jumper's Knee): A Systematic Review of the Literature. ( 26248496 )
2015
12
Retraction. Skin-derived fibroblasts for the treatment of refractory Achilles tendinosis: preliminary short-term results by H. Obaid, A. Clarke, P. Rosenfeld, C. Leach, and D. Connell. J Bone Joint Surg Am. 2012 Feb 1;94(3):193-200. ( 25878311 )
2015
13
Peroneal tendinosis as a predisposing factor for the acute lateral ankle sprain in runners. ( 25786820 )
2015
14
Achilles tendinosis: treatment options. ( 25729512 )
2015
15
Amniotic Tissues for the Treatment of Chronic Plantar Fasciosis and Achilles Tendinosis. ( 26491722 )
2015
16
The neuromechanical adaptations to Achilles tendinosis. ( 26046962 )
2015
17
Update to the retraction of "Skin-derived fibroblasts for the treatment of refractory Achilles tendinosis: preliminary short-term results" by H. Obaid, A. Clarke, P. Rosenfeld, C. Leach, and D. Connell. J Bone Joint Surg Am. 2012 Feb 1;94(3):193-200. ( 26085535 )
2015
18
Management of rotator cuff calcific tendinosis guided by ultrasound elastography. ( 26143386 )
2015
19
Gastrocnemius tendinosis-A frequent finding on MRI knee examination. ( 26456309 )
2015
20
A retrospective comparison of the management of recalcitrant lateral elbow tendinosis: platelet-rich plasma injections versus surgery. ( 26034445 )
2015
21
Quantitative MRI characterization of arthroscopically verified supraspinatus pathology: comparison of tendon tears, tendinosis and asymptomatic supraspinatus tendons with T2 mapping. ( 25739912 )
2015
22
Asymptomatic Elite Adolescent Tennis Players' Signs of Tendinosis in Their Dominant Shoulder Compared With Their Nondominant Shoulder. ( 26651279 )
2015
23
Trigger finger, tendinosis, and intratendinous gene expression. ( 22882155 )
2014
24
Sonoelastography findings of biceps tendinitis and tendinosis. ( 25368684 )
2014
25
The impact of posture on wrist tendinosis among blue-collar workers: the San Francisco study. ( 24669549 )
2014
26
An Achilles tendinosis masking an intramedullary astrocytoma. ( 25322734 )
2014
27
Combined intra-tendinous injection of Platelet Rich Plasma and bevacizumab accelerates and improves healing compared to Platelet Rich Plasma in tendinosis: comprehensive assessment on a rat model. ( 25489554 )
2014
28
Percutaneous ultrasonic tenotomy for chronic elbow tendinosis: a prospective study. ( 25306494 )
2014
29
Plantar Flexor Muscle Architecture Changes as a Result of Eccentric Exercise in Patients With Achilles Tendinosis. ( 25037955 )
2014
30
Injectable treatments for noninsertional achilles tendinosis: a systematic review. ( 23637232 )
2013
31
Dynamic contrast enhanced magnetic resonance imaging in chronic Achilles tendinosis. ( 24261480 )
2013
32
Early weightbearing using Achilles suture bridge technique for insertional Achilles tendinosis: a review of 43 patients. ( 23669005 )
2013
33
The plantaris tendon in association with mid-portion Achilles tendinosis: tendinosis-like morphological features and presence of a non-neuronal cholinergic system. ( 23378267 )
2013
34
Acute calcific tendinosis of the flexor hallucis brevis: case report. ( 23729205 )
2013
35
Flexor hallucis longus tendon transfer in treatment of Achilles tendinosis. ( 23283373 )
2013
36
Efficacy of intra-tendinous injection of platelet-rich plasma in treating tendinosis: comprehensive assessment of a rat model. ( 23801419 )
2013
37
Effects of tendon viscoelasticity in Achilles tendinosis on explosive performance and clinical severity in athletes. ( 22830527 )
2012
38
Is percutaneous radiofrequency coblation for treatment of Achilles tendinosis safe and effective? ( 22974813 )
2012
39
Ultrasonographic evaluation of canine supraspinatus calcifying tendinosis. ( 23033462 )
2012
40
Tendinopathy: why the difference between tendinitis and tendinosis matters. ( 22553479 )
2012
41
Eccentric training for the rehabilitation of a high level wrestler with distal biceps tendinosis: a case report. ( 22893861 )
2012
42
Achilles tendon reattachment after surgical treatment of insertional tendinosis using the suture bridge technique: a case series. ( 22579354 )
2012
43
Is calcaneal inclination higher in patients with insertional Achilles tendinosis? A case-controlled, cross-sectional study. ( 22819613 )
2012
44
Platelet rich plasma treatment for chronic Achilles tendinosis. ( 22735279 )
2012
45
Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors: a pilot study. ( 21819445 )
2011
46
Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy-peptidergic elevation preceding tendinosis-like tissue changes. ( 21625050 )
2011
47
Increased expression of cannabinoid CBa88 receptors in Achilles tendinosis. ( 21931835 )
2011
48
VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes. ( 18050306 )
2008
49
Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy). ( 17999088 )
2008
50
Autologous bone marrow plasma injection after arthroscopic debridement for elbow tendinosis. ( 18695767 )
2008

Variations for Tendinosis

Expression for Tendinosis

Search GEO for disease gene expression data for Tendinosis.

Pathways for Tendinosis

Pathways related to Tendinosis according to GeneCards Suite gene sharing:

(show all 24)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 BDNF CXCL10 PDGFRB TGFB2 TGFBR2 TIMP1
2
Show member pathways
12.59 DCN MMP1 MMP3 TGFB2 TIMP1
3 12.5 BDNF PDGFRB TGFB2 TGFBR2 TNFRSF1A
4 12.42 CNR1 NPY SLC17A6 TH
5
Show member pathways
12.4 ACHE CHAT CHRM2 SLC17A6 SLC18A3 TH
6 12.28 PDGFRB TGFB2 TGFBR2 TNFRSF1A
7 11.89 MMP1 TGFB2 TGFBR2 TNFRSF1A
8 11.84 MMP1 MMP3 TIMP1
9 11.83 BDNF CHAT CHRM2 TH
10 11.8 CXCL10 MMP3 TNFRSF1A
11
Show member pathways
11.76 MMP1 MMP3 TIMP1
12 11.71 MMP1 MMP3 TGFB2
13 11.66 DCN TGFB2 TGFBR2
14 11.63 BDNF CHAT TH
15 11.59 BDNF PDGFRB TGFB2 TIMP1
16
Show member pathways
11.5 MMP1 MMP3 TNFRSF1A
17 11.46 MMP1 MMP3 TIMP1
18 11.35 ACHE TGFB2 TH
19 11.27 CXCL10 TIMP1 TNFRSF1A
20 11.2 MMP3 PDGFRB TGFB2 TIMP1
21 10.9 MMP1 TIMP1
22
Show member pathways
10.67 ACHE CHAT TH
23 10.3 ACHE CHAT
24 10 ACHE CHAT SLC18A3 TH

GO Terms for Tendinosis

Cellular components related to Tendinosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 ACHE CXCL10 DCN MMP3 NPY TGFB2
2 extracellular matrix GO:0031012 9.35 DCN MMP1 MMP3 TGFB2 TIMP1
3 extracellular region GO:0005576 9.32 ACHE BDNF CXCL10 DCN MMP1 MMP3

Biological processes related to Tendinosis according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.91 CXCL10 PDGFRB TGFB2 TGFBR2 TIMP1
2 animal organ morphogenesis GO:0009887 9.73 DCN TGFBR2 TH
3 response to lipopolysaccharide GO:0032496 9.65 CNR1 CXCL10 DCN TH TNFRSF1A
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.63 DCN PDGFRB TGFB2
5 extracellular matrix disassembly GO:0022617 9.62 DCN MMP1 MMP3 TIMP1
6 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.58 CHRM2 CNR1 NPY
7 positive regulation of protein oligomerization GO:0032461 9.55 MMP1 MMP3
8 aging GO:0007568 9.55 CNR1 DCN PDGFRB TGFBR2 TIMP1
9 pathway-restricted SMAD protein phosphorylation GO:0060389 9.54 TGFB2 TGFBR2
10 atrioventricular valve morphogenesis GO:0003181 9.52 TGFB2 TGFBR2
11 dopamine biosynthetic process GO:0042416 9.49 TGFB2 TH
12 membranous septum morphogenesis GO:0003149 9.48 TGFB2 TGFBR2
13 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.43 TGFB2 TGFBR2
14 endocardial cushion fusion GO:0003274 9.37 TGFB2 TGFBR2
15 neurotransmitter biosynthetic process GO:0042136 9.13 ACHE CHAT TH
16 wound healing GO:0042060 9.02 DCN PDGFRB TGFB2 TGFBR2 TIMP1

Molecular functions related to Tendinosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 acetylcholine binding GO:0042166 8.62 ACHE SLC18A3

Sources for Tendinosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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