MCID: TNS001
MIFTS: 43

Tenosynovial Giant Cell Tumor malady

Muscle diseases, Cancer diseases categories

Summaries for Tenosynovial Giant Cell Tumor

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MalaCards: Tenosynovial Giant Cell Tumor, also known as fibrous histiocytoma of tendon sheath, is related to giant cell tumor and hemangioma. An important gene associated with Tenosynovial Giant Cell Tumor is DES (desmin), and among its related pathways are DNA damage ATM/ATR regulation of G1/S checkpoint and GADD45 Pathway. The compounds mucicarmine and hpvs have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are muscle and embryogenesis.

Aliases & Classifications for Tenosynovial Giant Cell Tumor

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Muscle diseases


Aliases & Descriptions:

tenosynovial giant cell tumor 8
fibrous histiocytoma of tendon sheath 8 60
giant cell tumor of tendon sheath 8
giant cell tumor of tenosynovium 8


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Disease Ontology8 DOID:314
NCIt39 C3402
ICD9CM27 727.02

Related Diseases for Tenosynovial Giant Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Tenosynovial Giant Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1giant cell tumor31.6CSF1, DES
2hemangioma30.7CLU, NF1
3neurofibromatosis30.4NF1
4pigmented villonodular synovitis10.8
5villonodular synovitis10.8
6synovitis10.8
7giant hemangioma10.5
8sclerosing hemangioma10.5
9nodular tenosynovitis10.4
10malignant giant cell tumor10.4
11carpal tunnel syndrome10.4
12wegener's granulomatosis10.4
13reactive arthritis10.3
14arthritis10.3
15bone giant cell tumor10.3
16cervicitis10.3
17rheumatoid arthritis10.3
18neuropathy10.0MYOG
19malignant mesenchymoma10.0MYOG
20rhabdoid tumor10.0DES
21adenosarcoma10.0DES
22angiosarcoma10.0CALB2
23leydig cell tumor10.0CALB2
24sertoli-leydig cell tumor10.0CALB2
25glomus tumor10.0DES
26neuroblastoma10.0TP53
27neutropenia10.0CSF1
28kidney cancer10.0TP53
29malignant pleural mesothelioma10.0CALB2
30endometriosis10.0CALB2
31adenomatoid tumor10.0CALB2
32cystadenoma10.0CLU
33glomerulonephritis10.0CLU
34thymoma10.0CALB2
35myofibrillar myopathy10.0DES
36vascular disease10.0TP53
37malignant fibroxanthoma10.0TP53
38anaplastic large cell lymphoma10.0CLU
39uterine sarcoma10.0DES
40dementia10.0CLU
41lung cancer10.0TP53
42chondrosarcoma10.0DES
43pseudosarcomatous fibromatosis10.0DES, MYOG
44benign meningioma10.0CCNA2
45leiomyoma10.0MYOG, DES
46alveolar soft part sarcoma10.0DES, MYOG
47dermatofibrosarcoma protuberans10.0DES
48alveolar rhabdomyosarcoma10.0DES, MYOG
49smooth muscle tumor10.0CCNA2, DES
50embryonal rhabdomyosarcoma10.0MYOG, DES

Graphical network of the top 20 diseases related to Tenosynovial Giant Cell Tumor:



Diseases related to tenosynovial giant cell tumor

Clinical Features for Tenosynovial Giant Cell Tumor

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Drugs & Therapeutics for Tenosynovial Giant Cell Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Tenosynovial Giant Cell Tumor

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Anatomical Context for Tenosynovial Giant Cell Tumor

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32MalaCards
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MalaCards organs/tissues related to Tenosynovial Giant Cell Tumor:

32
Bone

Animal Models for Tenosynovial Giant Cell Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tenosynovial Giant Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.9TP53, NF1, CSF1
2MP:00053807.8TP53, MYOG, NF1, CSF1, CCNA2
3MP:00053867.0CALB2, CSF1, DES, NF1, MYOG, TP53

Publications for Tenosynovial Giant Cell Tumor

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50PubMed
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Articles related to Tenosynovial Giant Cell Tumor:

(show all 49)
idTitleAuthorsYear
1
Partial response of a rare malignant metastatic diffuse tenosynovial giant cell tumor with benign histologic features, treated with SCH 717-454, an insulin growth factor receptor inhibitor, in combination with everolimus, an MTOR inhibitor. (23430345)
2013
2
Tenosynovial giant cell tumor in an unusual localization. (23619549)
2013
3
Tenosynovial giant cell tumor arising on the scapular region. (24403889)
2013
4
Chondroid tenosynovial giant cell tumor of the temporal bone. (23303171)
2013
5
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. (22784912)
2012
6
Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery. (22281719)
2012
7
Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. (21823110)
2012
8
Tenosynovial giant cell tumor in the cervico-thoracic junction. (23208911)
2012
9
Bilateral tenosynovial giant cell tumor of the knee accompanied by chronic ACL tear. (21590297)
2012
10
Tenosynovial giant cell tumor: case report and review. (22849738)
2012
11
Malignant diffuse-type tenosynovial giant cell tumor of the buttock. (22827766)
2012
12
Navigation-guided resection for a tenosynovial giant cell tumor involving the temporomandibular joint and skull base. (22421861)
2012
13
Tenosynovial giant cell tumor of the thigh: positron emission tomography findings. (21869945)
2011
14
Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. (21577109)
2011
15
Chondroid tenosynovial giant cell tumor: a clinicopathological and immunohistochemical analysis of 5 new cases. (21087985)
2011
16
Localized tenosynovial giant cell tumor in both knee joints. (20354849)
2010
17
Therapeutic Antibodies Targeting CSF1 Impede Macrophage Recruitment in a Xenograft Model of Tenosynovial Giant Cell Tumor. (20981142)
2010
18
Clusterin is expressed in normal synoviocytes and in tenosynovial giant cell tumors of localized and diffuse types: diagnostic and histogenetic implications. (19542874)
2009
19
Yellow nodule on the distal finger. Xanthomatous localized tenosynovial giant cell tumor (TGCT) of the finger. (19687429)
2009
20
Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT). (18296418)
2008
21
Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors. (17918257)
2008
22
Tenosynovial giant cell tumor of the posterior arch of C1. (18309482)
2008
23
Immunohistochemical and biogenetic features of diffuse-type tenosynovial giant cell tumors: the potential roles of cyclin A, P53, and deletion of 15q in sarcomatous transformation. (18829481)
2008
24
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
25
Tenosynovial giant cell tumor and pigmented villonodular synovitis. (17579851)
2007
26
Translocation and expression of CSF1 in pigmented villonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides. (17527089)
2007
27
Atypical tenosynovial giant cell tumor of the extensor hallucis longus tendon. (16868332)
2006
28
Diffuse-type tenosynovial giant cell tumor in association with neurofibromatosis type 1-Noonan syndrome: possibly more than a chance relationship. (16723851)
2006
29
A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. (16407111)
2006
30
Conditions suggesting lymphoma: case 3. Primary synovial lymphoma with osteoclast-like giant cells presenting as a tenosynovial giant-cell tumor. (15923579)
2005
31
Tenosynovial giant cell tumor]. (15657685)
2005
32
A large, multiply recurrent tenosynovial giant cell tumor of the hand treated with resection and radiation therapy. (15074461)
2004
33
Arthroscopic resection of an extra-articular tenosynovial giant cell tumor from the ankle region. (12966401)
2003
34
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
35
Localized tenosynovial giant cell tumor of tendon sheath. A case report. (10834013)
2000
36
Tenosynovial giant cell tumor of finger, localized type: a case report. (10642950)
1999
37
Analysis of 35 cases of localized and diffuse tenosynovial giant cell tumor: a report from the Chromosomes and Morphology (CHAMP) study group. (10392632)
1999
38
Diffuse variant tenosynovial giant cell tumor of the temporomandibular joint: report of a case. (9710197)
1998
39
Tenosynovial giant cell tumors: evidence for a desmin-positive dendritic cell subpopulation. (9796719)
1998
40
A new cytogenetic subgroup in tenosynovial giant cell tumors (nodular tenosynovitis) is characterized by involvement of 16q24. (8646750)
1996
41
Tenosynovial giant-cell tumor arising from the anterior cruciate ligament of the knee. (8864010)
1996
42
Tenosynovial giant-cell tumor in the knee joint. (7794435)
1995
43
Diffuse tenosynovial giant cell tumor of soft tissues. Report of a case with cytologic and cytogenetic findings. (7631554)
1995
44
Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis). (8033128)
1994
45
Diffuse-variant tenosynovial giant cell tumor: a rare and aggressive lesion. (8163276)
1994
46
Scintigraphic evaluation of tenosynovial giant-cell tumor using technetium-99m(V)-dimercaptosuccinic acid. (8410292)
1993
47
Diffuse type tenosynovial giant cell tumor of the ankle. (8386232)
1993
48
Tenosynovial giant-cell tumor of the cervical spine. Case report. (1331365)
1992
49
Diffuse and localized tenosynovial giant cell tumor and pigmented villonodular synovitis: a clinicopathologic and flow cytometric DNA analysis. (1319390)
1992

Genetic Variations for Tenosynovial Giant Cell Tumor

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Expression for genes affiliated with Tenosynovial Giant Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tenosynovial Giant Cell Tumor

Search GEO for disease gene expression data for Tenosynovial Giant Cell Tumor.

Pathways for genes affiliated with Tenosynovial Giant Cell Tumor

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12EMD Millipore, 51QIAGEN
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Pathways related to Tenosynovial Giant Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TP53, CCNA2
29.5TP53, CCNA2
3
Hide members
8.2TP53, NF1, DES, CSF1, COL6A3

Compounds for genes affiliated with Tenosynovial Giant Cell Tumor

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 2BitterDB, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Tenosynovial Giant Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1mucicarmine449.9CALB2, DES
2hpvs449.7CCNA2, TP53
3c2ceramide449.7CSF1, MYOG
4b 723449.6DES, CALB2
5olomoucine44 1110.6CCNA2, TP53
6hmba449.6CCNA2, TP53
7eb 108944 5910.6CLU, CCNA2
8colchicine59 44 2 28 1113.5CLU, NF1, CCNA2
9adpribose449.5CCNA2, DES, TP53
10acetylcholine44 49 28 11 2413.5CALB2, MYOG
11bcnu449.5TP53, CSF1
12hydroxyurea44 49 1111.5CSF1, CCNA2, TP53
13cytarabine44 49 1111.5TP53, CSF1, CCNA2
14docetaxel44 49 59 1112.4CLU, TP53, CCNA2
15camptothecin44 59 1111.4CLU, CCNA2, TP53
16arsenite44 2410.3CSF1, CCNA2, TP53
17ethanol44 49 11 2412.2CALB2, CCNA2, CLU, DES
18lysine449.2NF1, DES, CCNA2, CSF1
19bromodeoxyuridine449.2DES, MYOG, CCNA2
205fluorouracil449.2CCNA2, TP53, CSF1
21cd 437449.2TP53, CCNA2
22actinomycin d449.1CLU, DES, CSF1, TP53
23etoposide44 49 59 1112.1CSF1, TP53, CCNA2, CLU
24proline449.1DES, CCNA2, CLU, TP53
25fatty acid449.1CLU, MYOG, NF1
26cisplatin44 49 59 1112.0TP53, CSF1, CCNA2, CLU
2712-o-tetradecanoylphorbol 13-acetate449.0MYOG, DES, CSF1, CCNA2
28cycloheximide449.0TP53, CLU, CCNA2, CSF1
29dopamine44 28 11 2412.0CLU, CALB2, CCNA2, NF1
30doxorubicin44 49 1110.8DES, CSF1, CCNA2, TP53, CLU
31h2o2448.8CSF1, CLU, CCNA2, DES, TP53
32rapamycin448.8CSF1, MYOG, NF1, CCNA2
33ly294002448.7CCNA2, TP53, MYOG, CSF1
34arginine448.7CSF1, CCNA2, DES, NF1, TP53
35paclitaxel44 49 1110.6CCNA2, TP53, CLU, CSF1, CALB2
36adenylate448.5NF1, DES, CCNA2, CSF1, MYOG
37cysteine448.4CLU, MYOG, NF1, DES, CSF1
38thymidine44 249.3TP53, CLU, CCNA2, DES, CSF1, CALB2
39oligonucleotide448.1TP53, CLU, MYOG, NF1, CCNA2
40testosterone44 59 11 2411.1CALB2, CSF1, DES, CLU, CCNA2, MYOG
41vegf448.0CSF1, CCNA2, CLU, TP53, DES, MYOG
42steroid447.9MYOG, CALB2, NF1, CLU, CCNA2, DES
43butyrate447.8CLU, CCNA2, TP53, CALB2, CSF1, MYOG
44progesterone44 59 28 11 2411.8NF1, TP53, CCNA2, CALB2, CLU, CSF1
45calcium44 49 11 2410.7CALB2, DES, NF1, MYOG, CCNA2, CLU
46tyrosine447.6DES, CALB2, CLU, CSF1, CCNA2, NF1
47retinoic acid44 248.5TP53, NF1, DES, CLU, CSF1, CCNA2
48serine447.5CLU, CCNA2, CSF1, DES, NF1, TP53
49paraffin447.0CALB2, CLU, NF1, MYOG, TP53, DES
50estrogen447.0CALB2, TP53, CLU, NF1, DES, CSF1

GO Terms for genes affiliated with Tenosynovial Giant Cell Tumor

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16Gene Ontology
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Biological processes related to Tenosynovial Giant Cell Tumor according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuroblast proliferationGO:0074069.5TP53, NF1
2release of cytochrome c from mitochondriaGO:0018369.4CLU, TP53
3negative regulation of fibroblast proliferationGO:0481479.4NF1, TP53
4positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.3TP53, CLU
5positive regulation of neuron apoptotic processGO:0435259.3TP53, NF1
6positive regulation of cell cycle arrestGO:0711589.1TP53, MYOG
7Ras protein signal transductionGO:0072659.1TP53, NF1, CCNA2
8positive regulation of apoptotic processGO:0430658.6TP53, CLU, NF1

Molecular functions related to Tenosynovial Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positiGO:0012289.0TP53, MYOG

Products for genes affiliated with Tenosynovial Giant Cell Tumor

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Sources for Tenosynovial Giant Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet