MCID: TNS001
MIFTS: 37

Tenosynovial Giant Cell Tumor malady

Muscle, Cancer categories

Summaries for Tenosynovial Giant Cell Tumor

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33MalaCards
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MalaCards: Tenosynovial Giant Cell Tumor, also known as fibrous histiocytoma of tendon sheath, is related to neurofibromatosis and pigmented villonodular synovitis. An important gene associated with Tenosynovial Giant Cell Tumor is DES (desmin), and among its related pathways are DNA damage ATM/ATR regulation of G1/S checkpoint and GADD45 Pathway. The compounds mucicarmine and hpvs have been mentioned in the context of this disorder. Related mouse phenotypes are muscle and embryogenesis.

Aliases & Classifications for Tenosynovial Giant Cell Tumor

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Muscle


Aliases & Descriptions:

tenosynovial giant cell tumor 8
fibrous histiocytoma of tendon sheath 8 61
giant cell tumor of tendon sheath 8
giant cell tumor of tenosynovium 8


External Ids:

Disease Ontology8 DOID:314
NCIt40 C3402
ICD9CM27 727.02

Related Diseases for Tenosynovial Giant Cell Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tenosynovial Giant Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis30.4NF1
2pigmented villonodular synovitis10.8
3villonodular synovitis10.8
4synovitis10.8
5giant hemangioma10.5
6nodular tenosynovitis10.4
7carpal tunnel syndrome10.4
8wegener's granulomatosis10.4
9pyogenic granuloma10.4
10noonan syndrome10.3
11reactive arthritis10.3
12n syndrome10.3
13arthritis10.3
14bone giant cell tumor10.3
15neurofibromatosis-noonan syndrome10.3
16neuropathy10.0MYOG
17malignant mesenchymoma10.0MYOG
18rhabdoid tumor10.0DES
19adenosarcoma10.0DES
20angiosarcoma10.0CALB2
21leydig cell tumor10.0CALB2
22sertoli-leydig cell tumor10.0CALB2
23glomus tumor10.0DES
24neuroblastoma10.0TP53
25neutropenia10.0CSF1
26kidney cancer10.0TP53
27malignant pleural mesothelioma10.0CALB2
28endometriosis10.0CALB2
29adenomatoid tumor10.0CALB2
30cystadenoma10.0CLU
31glomerulonephritis10.0CLU
32thymoma10.0CALB2
33vascular disease10.0TP53
34myofibrillar myopathy10.0DES
35malignant fibroxanthoma10.0TP53
36anaplastic large cell lymphoma10.0CLU
37uterine sarcoma10.0DES
38dementia10.0CLU
39lung cancer10.0TP53
40chondrosarcoma10.0DES
41pseudosarcomatous fibromatosis10.0MYOG, DES
42benign meningioma10.0CCNA2
43leiomyoma10.0MYOG, DES
44alveolar soft part sarcoma10.0MYOG, DES
45dermatofibrosarcoma protuberans10.0DES
46alveolar rhabdomyosarcoma10.0MYOG, DES
47embryonal rhabdomyosarcoma10.0MYOG, DES
48smooth muscle tumor10.0CCNA2, DES
49schizophrenia10.0CALB2
50myopathy congenital10.0DES, MYOG

Graphical network of the top 20 diseases related to Tenosynovial Giant Cell Tumor:



Diseases related to tenosynovial giant cell tumor

Clinical Features for Tenosynovial Giant Cell Tumor

Drugs & Therapeutics for Tenosynovial Giant Cell Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Tenosynovial Giant Cell Tumor

Anatomical Context for Tenosynovial Giant Cell Tumor

Animal Models for Tenosynovial Giant Cell Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Tenosynovial Giant Cell Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.9CSF1, NF1, TP53
2MP:00053807.8TP53, NF1, CSF1, CCNA2, MYOG
3MP:00053867.0TP53, CALB2, CSF1, DES, NF1, MYOG

Publications for Tenosynovial Giant Cell Tumor

Sources:
51PubMed
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Articles related to Tenosynovial Giant Cell Tumor:

(show all 49)
idTitleAuthorsYear
1
Partial response of a rare malignant metastatic diffuse tenosynovial giant cell tumor with benign histologic features, treated with SCH 717-454, an insulin growth factor receptor inhibitor, in combination with everolimus, an MTOR inhibitor. (23430345)
2013
2
Tenosynovial giant cell tumor in an unusual localization. (23619549)
2013
3
Tenosynovial giant cell tumor arising on the scapular region. (24403889)
2013
4
Chondroid tenosynovial giant cell tumor of the temporal bone. (23303171)
2013
5
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. (22784912)
2012
6
Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery. (22281719)
2012
7
Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. (21823110)
2012
8
Tenosynovial giant cell tumor in the cervico-thoracic junction. (23208911)
2012
9
Bilateral tenosynovial giant cell tumor of the knee accompanied by chronic ACL tear. (21590297)
2012
10
Tenosynovial giant cell tumor: case report and review. (22849738)
2012
11
Malignant diffuse-type tenosynovial giant cell tumor of the buttock. (22827766)
2012
12
Navigation-guided resection for a tenosynovial giant cell tumor involving the temporomandibular joint and skull base. (22421861)
2012
13
Tenosynovial giant cell tumor of the thigh: positron emission tomography findings. (21869945)
2011
14
Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. (21577109)
2011
15
Chondroid tenosynovial giant cell tumor: a clinicopathological and immunohistochemical analysis of 5 new cases. (21087985)
2011
16
Localized tenosynovial giant cell tumor in both knee joints. (20354849)
2010
17
Therapeutic Antibodies Targeting CSF1 Impede Macrophage Recruitment in a Xenograft Model of Tenosynovial Giant Cell Tumor. (20981142)
2010
18
Clusterin is expressed in normal synoviocytes and in tenosynovial giant cell tumors of localized and diffuse types: diagnostic and histogenetic implications. (19542874)
2009
19
Yellow nodule on the distal finger. Xanthomatous localized tenosynovial giant cell tumor (TGCT) of the finger. (19687429)
2009
20
Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT). (18296418)
2008
21
Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors. (17918257)
2008
22
Tenosynovial giant cell tumor of the posterior arch of C1. (18309482)
2008
23
Immunohistochemical and biogenetic features of diffuse-type tenosynovial giant cell tumors: the potential roles of cyclin A, P53, and deletion of 15q in sarcomatous transformation. (18829481)
2008
24
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
25
Tenosynovial giant cell tumor and pigmented villonodular synovitis. (17579851)
2007
26
Translocation and expression of CSF1 in pigmented villonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides. (17527089)
2007
27
Atypical tenosynovial giant cell tumor of the extensor hallucis longus tendon. (16868332)
2006
28
Diffuse-type tenosynovial giant cell tumor in association with neurofibromatosis type 1-Noonan syndrome: possibly more than a chance relationship. (16723851)
2006
29
A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. (16407111)
2006
30
Conditions suggesting lymphoma: case 3. Primary synovial lymphoma with osteoclast-like giant cells presenting as a tenosynovial giant-cell tumor. (15923579)
2005
31
Tenosynovial giant cell tumor]. (15657685)
2005
32
A large, multiply recurrent tenosynovial giant cell tumor of the hand treated with resection and radiation therapy. (15074461)
2004
33
Arthroscopic resection of an extra-articular tenosynovial giant cell tumor from the ankle region. (12966401)
2003
34
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
35
Localized tenosynovial giant cell tumor of tendon sheath. A case report. (10834013)
2000
36
Tenosynovial giant cell tumor of finger, localized type: a case report. (10642950)
1999
37
Analysis of 35 cases of localized and diffuse tenosynovial giant cell tumor: a report from the Chromosomes and Morphology (CHAMP) study group. (10392632)
1999
38
Diffuse variant tenosynovial giant cell tumor of the temporomandibular joint: report of a case. (9710197)
1998
39
Tenosynovial giant cell tumors: evidence for a desmin-positive dendritic cell subpopulation. (9796719)
1998
40
A new cytogenetic subgroup in tenosynovial giant cell tumors (nodular tenosynovitis) is characterized by involvement of 16q24. (8646750)
1996
41
Tenosynovial giant-cell tumor arising from the anterior cruciate ligament of the knee. (8864010)
1996
42
Tenosynovial giant-cell tumor in the knee joint. (7794435)
1995
43
Diffuse tenosynovial giant cell tumor of soft tissues. Report of a case with cytologic and cytogenetic findings. (7631554)
1995
44
Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis). (8033128)
1994
45
Diffuse-variant tenosynovial giant cell tumor: a rare and aggressive lesion. (8163276)
1994
46
Scintigraphic evaluation of tenosynovial giant-cell tumor using technetium-99m(V)-dimercaptosuccinic acid. (8410292)
1993
47
Diffuse type tenosynovial giant cell tumor of the ankle. (8386232)
1993
48
Tenosynovial giant-cell tumor of the cervical spine. Case report. (1331365)
1992
49
Diffuse and localized tenosynovial giant cell tumor and pigmented villonodular synovitis: a clinicopathologic and flow cytometric DNA analysis. (1319390)
1992

Genetic Variations for Tenosynovial Giant Cell Tumor

Expression for genes affiliated with Tenosynovial Giant Cell Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tenosynovial Giant Cell Tumor

Search GEO for disease gene expression data for Tenosynovial Giant Cell Tumor.

Pathways for genes affiliated with Tenosynovial Giant Cell Tumor

Sources:
12EMD Millipore, 52QIAGEN
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Pathways related to Tenosynovial Giant Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TP53, CCNA2
29.5TP53, CCNA2
3
Hide members
8.2TP53, NF1, DES, CSF1, COL6A3

Compounds for genes affiliated with Tenosynovial Giant Cell Tumor

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 2BitterDB, 29IUPHAR, 50PharmGKB, 24HMDB
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Compounds related to Tenosynovial Giant Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1mucicarmine459.9CALB2, DES
2hpvs459.7CCNA2, TP53
3c2ceramide459.7MYOG, CSF1
4b 723459.6DES, CALB2
5olomoucine45 1110.6TP53, CCNA2
6hmba459.6CCNA2, TP53
7eb 108945 6010.6CCNA2, CLU
8colchicine60 45 2 29 1113.5CLU, NF1, CCNA2
9adpribose459.5TP53, DES, CCNA2
10acetylcholine45 50 29 11 2413.5CALB2, MYOG
11bcnu459.5TP53, CSF1
12hydroxyurea45 50 1111.5CCNA2, CSF1, TP53
13cytarabine45 50 1111.5CCNA2, CSF1, TP53
14docetaxel45 50 60 1112.4TP53, CLU, CCNA2
15camptothecin45 60 1111.4CCNA2, CLU, TP53
16arsenite45 2410.3TP53, CSF1, CCNA2
17ethanol45 50 11 2412.2CCNA2, CALB2, DES, CLU
18lysine459.2CCNA2, CSF1, DES, NF1
19bromodeoxyuridine459.2MYOG, DES, CCNA2
205fluorouracil459.2TP53, CSF1, CCNA2
21cd 437459.2TP53, CCNA2
22actinomycin d459.1CSF1, DES, CLU, TP53
23etoposide45 50 60 1112.1TP53, CLU, CSF1, CCNA2
24proline459.1TP53, CLU, DES, CCNA2
25fatty acid459.1CLU, MYOG, NF1
26cisplatin45 50 60 1112.0CCNA2, CSF1, CLU, TP53
2712-o-tetradecanoylphorbol 13-acetate459.0CCNA2, CSF1, DES, MYOG
28cycloheximide459.0TP53, CLU, CSF1, CCNA2
29dopamine45 29 11 2412.0CLU, NF1, CALB2, CCNA2
30doxorubicin45 50 1110.8CCNA2, CSF1, DES, CLU, TP53
31h2o2458.8CCNA2, CSF1, DES, CLU, TP53
32rapamycin458.8MYOG, NF1, CSF1, CCNA2
33ly294002458.7CCNA2, CSF1, MYOG, TP53
34arginine458.7TP53, NF1, DES, CSF1, CCNA2
35paclitaxel45 50 1110.6CCNA2, CALB2, CSF1, CLU, TP53
36adenylate458.5CCNA2, CSF1, DES, NF1, MYOG
37cysteine458.4CSF1, DES, NF1, MYOG, CLU
38thymidine45 249.3CCNA2, CALB2, CSF1, DES, CLU, TP53
39oligonucleotide458.1CCNA2, NF1, MYOG, CLU, TP53
40testosterone45 60 11 2411.1CCNA2, CALB2, CSF1, DES, MYOG, CLU
41vegf458.0CCNA2, CSF1, DES, MYOG, CLU, TP53
42steroid457.9CCNA2, CALB2, DES, NF1, MYOG, CLU
43butyrate457.8CCNA2, CALB2, CSF1, MYOG, CLU, TP53
44progesterone45 60 29 11 2411.8CCNA2, CALB2, CSF1, DES, NF1, CLU
45calcium45 50 11 2410.7CCNA2, CALB2, DES, NF1, MYOG, CLU
46tyrosine457.6CCNA2, CALB2, CSF1, DES, NF1, MYOG
47retinoic acid45 248.5CCNA2, CSF1, DES, NF1, MYOG, CLU
48serine457.5CCNA2, CSF1, DES, NF1, MYOG, CLU
49paraffin457.0TP53, CCNA2, CALB2, CSF1, DES, NF1
50estrogen457.0CCNA2, CALB2, CSF1, DES, NF1, MYOG

GO Terms for genes affiliated with Tenosynovial Giant Cell Tumor

Sources:
16Gene Ontology
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Biological processes related to Tenosynovial Giant Cell Tumor according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuroblast proliferationGO:0074069.5TP53, NF1
2release of cytochrome c from mitochondriaGO:0018369.4CLU, TP53
3negative regulation of fibroblast proliferationGO:0481479.4NF1, TP53
4positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.3TP53, CLU
5positive regulation of neuron apoptotic processGO:0435259.3TP53, NF1
6positive regulation of cell cycle arrestGO:0711589.1TP53, MYOG
7Ras protein signal transductionGO:0072659.1TP53, NF1, CCNA2
8positive regulation of apoptotic processGO:0430658.6TP53, CLU, NF1

Molecular functions related to Tenosynovial Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positiGO:0012289.0TP53, MYOG

Products for genes affiliated with Tenosynovial Giant Cell Tumor

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Sources for Tenosynovial Giant Cell Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet