MCID: TNS001
MIFTS: 34

Tenosynovial Giant Cell Tumor malady

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Tenosynovial Giant Cell Tumor

Aliases & Descriptions for Tenosynovial Giant Cell Tumor:

Name: Tenosynovial Giant Cell Tumor 12 14
Fibrous Histiocytoma of Tendon Sheath 12 69
Giant Cell Tumor of Tendon Sheath 12
Giant Cell Tumor of Tenosynovium 12

Classifications:



External Ids:

Disease Ontology 12 DOID:314
ICD9CM 35 727.02
NCIt 47 C3402
UMLS 69 C1318543

Summaries for Tenosynovial Giant Cell Tumor

MalaCards based summary : Tenosynovial Giant Cell Tumor, also known as fibrous histiocytoma of tendon sheath, is related to pigmented villonodular synovitis and giant cell tumor. An important gene associated with Tenosynovial Giant Cell Tumor is CSF1 (Colony Stimulating Factor 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Hematopoietic cell lineage. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone and salivary gland, and related phenotype is muscle.

Related Diseases for Tenosynovial Giant Cell Tumor

Graphical network of the top 20 diseases related to Tenosynovial Giant Cell Tumor:



Diseases related to Tenosynovial Giant Cell Tumor

Symptoms & Phenotypes for Tenosynovial Giant Cell Tumor

MGI Mouse Phenotypes related to Tenosynovial Giant Cell Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.92 CD163 CLU COL6A3 CSF1

Drugs & Therapeutics for Tenosynovial Giant Cell Tumor

Drugs for Tenosynovial Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1, Phase 2
2 Immunoglobulins Phase 1, Phase 2
3 Grapefruit Seed Extract Nutraceutical Phase 2
4
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
5 Albumin-Bound Paclitaxel Phase 1
6 Antimitotic Agents Phase 1
7 Antineoplastic Agents, Phytogenic Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3
2 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2
3 Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Recruiting NCT02471716 Phase 1, Phase 2
4 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS) Recruiting NCT01643850 Phase 2
5 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2
6 A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor Recruiting NCT02673736 Phase 1
7 Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors Recruiting NCT01804530 Phase 1
8 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Active, not recruiting NCT01494688 Phase 1
9 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088

Search NIH Clinical Center for Tenosynovial Giant Cell Tumor

Genetic Tests for Tenosynovial Giant Cell Tumor

Anatomical Context for Tenosynovial Giant Cell Tumor

MalaCards organs/tissues related to Tenosynovial Giant Cell Tumor:

39
Bone, Salivary Gland

Publications for Tenosynovial Giant Cell Tumor

Articles related to Tenosynovial Giant Cell Tumor:

(show top 50) (show all 73)
id Title Authors Year
1
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
2
Diffuse Type Tenosynovial Giant Cell Tumor of the Ankle. ( 26996490 )
2016
3
Intramuscular Tenosynovial Giant Cell Tumor, Diffuse-Type. ( 26755356 )
2016
4
Tenosynovial Giant Cell Tumor in the Dermis of the External Auditory Meatus. ( 27072732 )
2016
5
Coexisting sarcoidal granulomatous inflammation and diffuse tenosynovial giant cell tumor of the knee after a total knee replacement: a case report. ( 27717976 )
2016
6
Malignant tenosynovial giant cell tumor with CDKN2A/B genomic alteration: a histological, immunohistochemical, and molecular study. ( 27989786 )
2016
7
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. ( 26820289 )
2016
8
Fine Needle Aspiration Cytology of Chondroid Tenosynovial Giant Cell Tumor of the Hand. ( 26266013 )
2015
9
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. ( 26337311 )
2015
10
Tenosynovial Giant Cell Tumor, Diffuse Type/Pigmented Villonodular Synovitis in a Pars Defect: A Case Report. ( 26067150 )
2015
11
Tenosynovial giant cell tumor arising from the posterior cruciate ligament: a case report and literature review. ( 26261570 )
2015
12
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. ( 26222558 )
2015
13
Malignant tenosynovial giant cell tumor of the leg: a radiologic-pathologic correlation and review of the literature. ( 25861547 )
2015
14
Arthroscopic Resection of a Tenosynovial Giant Cell Tumor in the Wrist: A Case Report. ( 26496348 )
2015
15
Primary diffuse-type tenosynovial giant cell tumor of the spine: a report of 3 cases and systemic review of the literature. ( 25269059 )
2014
16
Novel CSF1-S100A10 fusion gene and CSF1 transcript identified by RNA sequencing in tenosynovial giant cell tumors. ( 24604026 )
2014
17
Intramuscular diffuse-type tenosynovial giant cell tumor of the deltoid muscle in a child. ( 24676801 )
2014
18
Tenosynovial Giant Cell Tumor of Diffuse Type Mimicking Bony Metastasis Detected on F-18 FDG PET/CT. ( 25177381 )
2014
19
Recurrent temporal bone tenosynovial giant cell tumor with chondroid metaplasia: the use of imaging to assess recurrence. ( 24571839 )
2014
20
Multiple metastases from histologically benign intraarticular diffuse-type tenosynovial giant cell tumor: a case report. ( 25130396 )
2014
21
A tenosynovial giant cell tumor arising from femoral attachment of the anterior cruciate ligament. ( 24900909 )
2014
22
Tenosynovial giant cell tumor presenting as a parotid gland mass: Expanding the differential diagnosis of giant cell-rich lesions in salivary glands. ( 25745294 )
2014
23
Hepatoid tenosynovial giant cell tumor - A rare morphologic variant case report. ( 25023880 )
2014
24
Diffuse-type tenosynovial giant cell tumor with t(1;17)(p13;p13) and trisomy 5. ( 25189912 )
2014
25
Tenosynovial giant cell tumor in an unusual localization. ( 23619549 )
2013
26
Chondroid tenosynovial giant cell tumor of the temporal bone. ( 23303171 )
2013
27
Tenosynovial giant cell tumor arising on the scapular region. ( 24403889 )
2013
28
Partial response of a rare malignant metastatic diffuse tenosynovial giant cell tumor with benign histologic features, treated with SCH 717-454, an insulin growth factor receptor inhibitor, in combination with everolimus, an MTOR inhibitor. ( 23430345 )
2013
29
Malignant diffuse-type tenosynovial giant cell tumor of the buttock. ( 22827766 )
2012
30
Navigation-guided resection for a tenosynovial giant cell tumor involving the temporomandibular joint and skull base. ( 22421861 )
2012
31
Tenosynovial giant cell tumor in the cervico-thoracic junction. ( 23208911 )
2012
32
Bilateral tenosynovial giant cell tumor of the knee accompanied by chronic ACL tear. ( 21590297 )
2012
33
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. ( 22784912 )
2012
34
Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. ( 21823110 )
2012
35
Tenosynovial giant cell tumor: case report and review. ( 22849738 )
2012
36
Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery. ( 22281719 )
2012
37
Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. ( 21577109 )
2011
38
Tenosynovial giant cell tumor of the thigh: positron emission tomography findings. ( 21869945 )
2011
39
Chondroid tenosynovial giant cell tumor: a clinicopathological and immunohistochemical analysis of 5 new cases. ( 21087985 )
2011
40
Localized tenosynovial giant cell tumor in both knee joints. ( 20354849 )
2010
41
Therapeutic Antibodies Targeting CSF1 Impede Macrophage Recruitment in a Xenograft Model of Tenosynovial Giant Cell Tumor. ( 20981142 )
2010
42
Clusterin is expressed in normal synoviocytes and in tenosynovial giant cell tumors of localized and diffuse types: diagnostic and histogenetic implications. ( 19542874 )
2009
43
Yellow nodule on the distal finger. Xanthomatous localized tenosynovial giant cell tumor (TGCT) of the finger. ( 19687429 )
2009
44
Tenosynovial giant cell tumor of the posterior arch of C1. ( 18309482 )
2008
45
Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT). ( 18296418 )
2008
46
Immunohistochemical and biogenetic features of diffuse-type tenosynovial giant cell tumors: the potential roles of cyclin A, P53, and deletion of 15q in sarcomatous transformation. ( 18829481 )
2008
47
Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors. ( 17918257 )
2008
48
Tenosynovial giant cell tumor and pigmented villonodular synovitis. ( 17579851 )
2007
49
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. ( 17225151 )
2007
50
Translocation and expression of CSF1 in pigmented villonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides. ( 17527089 )
2007

Variations for Tenosynovial Giant Cell Tumor

Expression for Tenosynovial Giant Cell Tumor

Search GEO for disease gene expression data for Tenosynovial Giant Cell Tumor.

Pathways for Tenosynovial Giant Cell Tumor

GO Terms for Tenosynovial Giant Cell Tumor

Cellular components related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.65 CLU COL6A3 CSF1 PGM1 SERPINA3
2 extracellular region GO:0005576 9.43 CD163 CLU COL6A3 CSF1 PGM1 SERPINA3
3 platelet alpha granule lumen GO:0031093 9.16 CLU SERPINA3
4 CSF1-CSF1R complex GO:1990682 8.62 CSF1 CSF1R

Biological processes related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.61 CLU CSF1 CSF1R
2 immune system process GO:0002376 9.58 CLU CSF1 CSF1R
3 hemopoiesis GO:0030097 9.37 CSF1 CSF1R
4 acute-phase response GO:0006953 9.32 CD163 SERPINA3
5 osteoclast differentiation GO:0030316 9.26 CSF1 CSF1R
6 inflammatory response GO:0006954 9.26 CD163 CSF1 CSF1R SERPINA3
7 macrophage differentiation GO:0030225 9.16 CSF1 CSF1R
8 macrophage colony-stimulating factor signaling pathway GO:0038145 8.62 CSF1 CSF1R

Molecular functions related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase inhibitor activity GO:0004867 8.62 COL6A3 SERPINA3

Sources for Tenosynovial Giant Cell Tumor

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9 Cosmic
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68 Tocris
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70 UMLS via Orphanet
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