MCID: TNS001
MIFTS: 33

Tenosynovial Giant Cell Tumor malady

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Tenosynovial Giant Cell Tumor

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Aliases & Descriptions for Tenosynovial Giant Cell Tumor:

Name: Tenosynovial Giant Cell Tumor 10 12
Fibrous Histiocytoma of Tendon Sheath 10 65
 
Giant Cell Tumor of Tendon Sheath 10
Giant Cell Tumor of Tenosynovium 10

Classifications:



External Ids:

Disease Ontology10 DOID:314
ICD9CM29 727.02
NCIt42 C3402
UMLS65 C1318543

Summaries for Tenosynovial Giant Cell Tumor

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MalaCards based summary: Tenosynovial Giant Cell Tumor, also known as fibrous histiocytoma of tendon sheath, is related to pigmented villonodular synovitis and breast cancer. An important gene associated with Tenosynovial Giant Cell Tumor is CSF1 (Colony Stimulating Factor 1), and among its related pathways are Macrophage Differentiation and Growth Inhibition by METS and Integrins in angiogenesis. Affiliated tissues include t cells, breast and liver.

Related Diseases for Tenosynovial Giant Cell Tumor

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Graphical network of the top 20 diseases related to Tenosynovial Giant Cell Tumor:



Diseases related to tenosynovial giant cell tumor

Symptoms for Tenosynovial Giant Cell Tumor

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Drugs & Therapeutics for Tenosynovial Giant Cell Tumor

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Drugs for Tenosynovial Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ImmunoglobulinsPhase 1, Phase 24477
2AntibodiesPhase 1, Phase 24477
3Grapefruit Seed ExtractNutraceuticalPhase 238
4
GemcitabineapprovedPhase 1188195058-81-460750
Synonyms:
103882-84-4
122111-03-9
2',2'-DiF-dC
2',2'-Difluoro-2'-deoxycytidine
2',2'-Difluorodeoxycytidine
2'-Deoxy-.beta.-D-2',2'-difluorocytidine
2'-Deoxy-2',2'-difluorocytidine
4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one
4-amino-1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
95058-81-4
AB1004842
AC1L1TUQ
C07650
CCRIS 8984
CHEBI:175901
CHEMBL888
CID60750
Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine
D02368
DB00441
DDFC
DFDC
DFdC
DFdCyd
Folfugem
GEO
Gamcitabine
GemLip
Gemcel
 
Gemcin
Gemcitabin
Gemcitabina
Gemcitabina [INN-Spanish]
Gemcitabine
Gemcitabine (USAN/INN)
Gemcitabine HCl
Gemcitabine Hydrochloride
Gemcitabine hydrochloride
Gemcitabine stereoisomer
Gemcitabinum
Gemcitabinum [INN-Latin]
Gemtro
Gemzar
Gemzar (hydrochloride)
HMS2089P10
HSDB 7567
Inno-D07001
LS-59139
LY 188011
LY-188011
LY188011
NCGC00168784-01
NChemBio.2007.10-comp25
NSC 613327
NSC613327
TL8005979
UNII-B76N6SBZ8R
ZINC18279854
Zefei
gemcitabine
nchembio.573-comp7
nchembio.90-comp2
5
PaclitaxelapprovedPhase 1262133069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
6Tubulin ModulatorsPhase 14279
7Antiviral AgentsPhase 18071
8Immunologic FactorsPhase 118483
9Immunosuppressive AgentsPhase 110422
10Antimitotic AgentsPhase 14296
11Albumin-Bound PaclitaxelPhase 12621
12Anti-Infective AgentsPhase 117220
13AntimetabolitesPhase 19454
14Antimetabolites, AntineoplasticPhase 15770
15Antineoplastic Agents, PhytogenicPhase 14294

Interventional clinical trials:

idNameStatusNCT IDPhase
1PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)RecruitingNCT02371369Phase 3
2Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)CompletedNCT01261429Phase 2
3Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell TumorRecruitingNCT02471716Phase 1, Phase 2
4MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)RecruitingNCT01643850Phase 2
5Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell TumorActive, not recruitingNCT01207492Phase 2
6A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell TumorRecruitingNCT02673736Phase 1
7Phase 1 Study of PLX7486 as Single Agent and With Gemcitabine Plus Nab-Paclitaxel in Patients With Advanced Solid TumorsRecruitingNCT01804530Phase 1
8A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Patients With Advanced Solid TumorsRecruitingNCT01494688Phase 1
9Safety Study of PLX108-01 in Patients With Solid TumorsActive, not recruitingNCT01004861Phase 1

Search NIH Clinical Center for Tenosynovial Giant Cell Tumor

Genetic Tests for Tenosynovial Giant Cell Tumor

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Anatomical Context for Tenosynovial Giant Cell Tumor

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MalaCards organs/tissues related to Tenosynovial Giant Cell Tumor:

33
T cells, Breast, Liver, Prostate, Testes, Cervix, Nk cells

Animal Models for Tenosynovial Giant Cell Tumor or affiliated genes

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Publications for Tenosynovial Giant Cell Tumor

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Articles related to Tenosynovial Giant Cell Tumor:

(show top 50)    (show all 66)
idTitleAuthorsYear
1
Prolyl-hydroxylase inhibitor activating hypoxia-inducible transcription factors reduce levels of transplant arteriosclerosis in a murine aortic allograft model. (26819270)
2016
2
Expression of ERG protein in prostate cancer: variability and biological correlates. (25972242)
2015
3
The alternative splicing of the apolipoprotein E gene is unperturbed in the brains of Alzheimer's disease patients. (24996286)
2014
4
Monostotic fibrous dysplasia of the proximal femur: natural history and predisposing factors for disease progression. (24788504)
2014
5
IL-4RI+, a STUB-strate for Proteasomal Degradation: Understanding the Termination of Cytokine Signaling in Asthma. (24381986)
2014
6
Impact of the hypoxia-inducible factor-1 I+ (HIF1A) Pro582Ser polymorphism on diabetes nephropathy. (22991450)
2013
7
Links between DRD4, executive attention, and alphabetic skills in a nonclinical sample. (22897338)
2013
8
HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells. (24236056)
2013
9
Clinical characteristics and risk factors for mortality in cefepime-resistant Pseudomonas aeruginosa bacteremia. (24064286)
2013
10
Posttraumatic subgaleal and orbital hematoma due to factor XIII deficiency. (21284470)
2011
11
Splenic infarction associated with rapidly progressive chronic lymphocytic leukemia with complex karyotype and ATM mutation. (21185599)
2011
12
Meta-analysis of the association between single nucleotide polymorphisms in TGF-I^ receptor genes and abdominal aortic aneurysm. (21855067)
2011
13
Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer--a case control study. (21104022)
2011
14
Comments regarding 'Walking performance and health-related quality of life after surgical or endovascular invasive versus non-invasive treatment for intermittent claudication--a prospective randomised trial'. (21531592)
2011
15
Involvement of genetic instability in the downregulation of sFRP1 in Chinese patients with hepatocellular carcinoma. (21046672)
2010
16
Gaucher's disease type I: a disease masked by the presence of abnormal laboratory tests common to primary liver disease. (20093936)
2010
17
The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1. (19389703)
2009
18
Acute interstitial pneumonia in feedlot cattle: effects of feeding feather meal or vitamin E. (17479779)
2007
19
Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review. (17464974)
2007
20
Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway. (17182967)
2007
21
Mycotoxins nivalenol and deoxynivalenol differentially modulate cytokine mRNA expression in Jurkat T cells. (17166736)
2006
22
CD10 expression in stromal cells of oral cavity squamous cell carcinoma: a clinic and pathologic correlation. (16700740)
2006
23
Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population. (16228113)
2005
24
Is laser conization adequate for therapeutic excision of adenocarcinoma in situ of the uterine cervix? (15916663)
2005
25
Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development. (15657426)
2005
26
Q188R, K285N, and N314D mutation-associated alleles in the galactose-1-phosphate uridyltransferase gene and female infertility. (15749517)
2005
27
Germline mutational dynamics in myotonic dystrophy type 1 males: allele length and age effects. (14745066)
2004
28
Development of a rapid genotyping method for single nucleotide polymorphisms and its application in cancer studies. (14719090)
2004
29
LXR/RXR ligand activation enhances basolateral efflux of beta-sitosterol in CaCo-2 cells. (14993242)
2004
30
Relationship between dexamethasone-inhibited lysozyme activity in peripheral mononuclear leukocytes and the cortisol and glucocorticoid receptor response to dexamethasone. (14563378)
2003
31
Characterization of a putative type IV aminophospholipid transporter P-type ATPase. (12532265)
2003
32
The Val-210-Ile pathogenic Creutzfeldt-Jakob disease mutation increases both the helical and aggregation propensities of a sequence corresponding to helix-3 of PrP(C). (11341933)
2001
33
Multimodal treatment of metastatic thymic carcinoma including high-dose chemotherapy with autologous stem cell transplantation: report of a case with more than 4-year disease-free survival. (11801755)
2001
34
Interaction of eIF4G with poly(A)-binding protein stimulates translation and is critical for Xenopus oocyte maturation. (10996799)
2000
35
Galectin-3 is associated with the plasma membrane of lens fiber cells. (10634621)
2000
36
Expression of serum amyloid A protein in the absence of the acute phase response does not reduce HDL cholesterol or apoA-I levels in human apoA-I transgenic mice. (10191288)
1999
37
Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain. (10051333)
1999
38
Serum leptin and insulin concentrations in prepubertal lean, obese and insulin-dependent diabetes mellitus children. (9861331)
1998
39
Cutaneous disseminated actinomycosis in a patient with acute lymphocytic leukemia. (9519608)
1998
40
p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha. (9407140)
1997
41
A keratin K5 mutation (Leu 463-->Pro) in a family with the Weber-Cockayne type of epidermolysis bullosa simplex. (9266030)
1997
42
Comparative concentrations of growth hormone-binding protein in maternal circulation, fetal circulation, and amniotic fluid. (9152622)
1997
43
The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. (8752281)
1996
44
Immunoreactive elastase I: clinical evaluation of a new noninvasive test of pancreatic function. (8595714)
1996
45
Suramin inhibits growth and yet promotes insulin-like growth factor II expression in HepG2 cells. (8381048)
1993
46
Administration of human recombinant granulocyte colony-stimulating factor (filgrastim) accelerates granulocyte recovery following high-dose chemotherapy and autologous marrow transplantation with 4-hydroperoxycyclophosphamide-purged marrow in women with metastatic breast cancer. (7693341)
1993
47
A foregut carcinoid tumor causing Zollinger-Ellison syndrome. (2919971)
1989
48
Estrogen receptors in bilateral breast cancer. (3383109)
1988
49
Treatment of superior limbic keratoconjunctivitis with topical cromolyn sodium. (3113315)
1987
50
Peripheral blood NK cells in patients with extrinsic allergic alveolitis: phenotype and function. (2437628)
1986

Variations for Tenosynovial Giant Cell Tumor

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Expression for genes affiliated with Tenosynovial Giant Cell Tumor

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Search GEO for disease gene expression data for Tenosynovial Giant Cell Tumor.

Pathways for genes affiliated with Tenosynovial Giant Cell Tumor

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GO Terms for genes affiliated with Tenosynovial Giant Cell Tumor

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Biological processes related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1macrophage colony-stimulating factor signaling pathwayGO:003814510.0CSF1, CSF1R
2macrophage differentiationGO:00302259.9CSF1, CSF1R
3osteoclast differentiationGO:00303169.8CSF1, CSF1R
4positive regulation of osteoclast differentiationGO:00456729.7CSF1, CSF1R
5phosphatidylinositol metabolic processGO:00464889.5CSF1R, PDGFRB
6phosphatidylinositol-mediated signalingGO:00480159.3CSF1R, PDGFRB

Sources for Tenosynovial Giant Cell Tumor

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet