MCID: TNS001
MIFTS: 38

Tenosynovial Giant Cell Tumor

Categories: Muscle diseases, Cancer diseases

Aliases & Classifications for Tenosynovial Giant Cell Tumor

MalaCards integrated aliases for Tenosynovial Giant Cell Tumor:

Name: Tenosynovial Giant Cell Tumor 12 14
Fibrous Histiocytoma of Tendon Sheath 12 69
Giant Cell Tumor of Tendon Sheath 12
Giant Cell Tumor of Tenosynovium 12

Classifications:



External Ids:

Disease Ontology 12 DOID:314
ICD9CM 34 727.02
NCIt 46 C3402
UMLS 69 C1318543

Summaries for Tenosynovial Giant Cell Tumor

MalaCards based summary : Tenosynovial Giant Cell Tumor, also known as fibrous histiocytoma of tendon sheath, is related to pigmented villonodular synovitis and giant cell tumor. An important gene associated with Tenosynovial Giant Cell Tumor is CSF1 (Colony Stimulating Factor 1), and among its related pathways/superpathways are ERK Signaling and Hematopoietic cell lineage. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone, salivary gland and brain, and related phenotype is no phenotypic analysis.

Related Diseases for Tenosynovial Giant Cell Tumor

Diseases related to Tenosynovial Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 pigmented villonodular synovitis 33.0 CSF1 CSF1R
2 giant cell tumor 10.9
3 synovitis 10.5
4 villonodular synovitis 10.5
5 thyroid lymphoma 10.2 CDKN2A CDKN2B
6 scrotal carcinoma 10.2 CDKN2A CDKN2B
7 atypical neurofibroma 10.2 CDKN2A CDKN2B
8 ewing's family of tumors 10.2 CDKN2A CDKN2B
9 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.2 CSF1 CSF1R
10 grade iii astrocytoma 10.2 CDKN2A CDKN2B
11 acute lymphoblastic leukemia, childhood 10.1 CDKN2A CDKN2B
12 malignant histiocytosis 10.1 CSF1 CSF1R
13 skin melanoma 10.1 CDKN2A CDKN2B
14 leukemia, acute lymphoblastic 3 10.1 CDKN2A CDKN2B
15 nervous system cancer 10.1 CDKN2A CDKN2B
16 melanoma, cutaneous malignant 1 10.1 CDKN2A CDKN2B
17 nodular tenosynovitis 10.1
18 tenosynovitis 10.1
19 leukemia, acute lymphoblastic 10.0 CDKN2A CDKN2B
20 precursor t-cell acute lymphoblastic leukemia 10.0 CDKN2A CDKN2B
21 acute lymphocytic leukemia 9.9 CDKN2A CDKN2B
22 neurofibromatosis, type iv, of riccardi 9.9
23 rheumatoid arthritis 9.9
24 arthritis 9.9
25 lymphoma 9.9
26 cervicitis 9.9
27 histiocytic sarcoma 9.8 CDKN2A CSF1 CSF1R
28 myelodysplastic syndrome 9.8 CDKN2B CSF1 CSF1R
29 oligodendroglioma 9.7 CDKN2A CDKN2B
30 anaplastic large cell lymphoma 9.7 CLU CSF1R
31 congenital disorder of glycosylation, type in 9.6 CLU PGM1
32 leukemia, acute myeloid 9.5 CDKN2A CDKN2B CSF1 CSF1R
33 bladder cancer 9.3 CDKN2A CDKN2B CLU

Graphical network of the top 20 diseases related to Tenosynovial Giant Cell Tumor:



Diseases related to Tenosynovial Giant Cell Tumor

Symptoms & Phenotypes for Tenosynovial Giant Cell Tumor

MGI Mouse Phenotypes related to Tenosynovial Giant Cell Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 8.92 CSF1 CSF1R CDKN2A CDKN2B

Drugs & Therapeutics for Tenosynovial Giant Cell Tumor

Drugs for Tenosynovial Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1, Phase 2
2 Immunoglobulins Phase 1, Phase 2
3 Grapefruit Seed Extract Nutraceutical Phase 2
4
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
5
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
6
Warfarin Approved Phase 1 81-81-2 54678486 6691
7
Menadione Approved, Nutraceutical Phase 1 58-27-5 4055
8
Phytonadione Approved, Investigational, Nutraceutical Phase 1 84-80-0 5284607 4812
9 Albumin-Bound Paclitaxel Phase 1
10 Antimitotic Agents Phase 1
11 Antineoplastic Agents, Phytogenic Phase 1
12 Adjuvants, Anesthesia Phase 1
13 Anesthetics Phase 1
14 Anesthetics, General Phase 1
15 Anesthetics, Intravenous Phase 1
16 Anti-Anxiety Agents Phase 1
17 Anticoagulants Phase 1
18 Antifibrinolytic Agents Phase 1
19 Central Nervous System Depressants Phase 1
20 Coagulants Phase 1
21 GABA Agents Phase 1
22 GABA Modulators Phase 1
23 Hemostatics Phase 1
24 Hypnotics and Sedatives Phase 1
25 Micronutrients Phase 1
26 Neurotransmitter Agents Phase 1
27 Psychotropic Drugs Phase 1
28 Trace Elements Phase 1
29 Tranquilizing Agents Phase 1
30 Vitamins Phase 1
31 Menaquinone Nutraceutical Phase 1
32 naphthoquinone Nutraceutical Phase 1
33 Vitamin K Nutraceutical Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3 PLX3397;Placebo
2 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
3 Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Recruiting NCT02471716 Phase 1, Phase 2 FPA008
4 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
5 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS) Active, not recruiting NCT01643850 Phase 2 MCS110;Placebo
6 A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor Active, not recruiting NCT02673736 Phase 1 PLX73086
7 Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors Active, not recruiting NCT01804530 Phase 1 PLX7486 TsOH
8 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Active, not recruiting NCT01494688 Phase 1 Paclitaxel;RO5509554
9 Pexidartinib Effects on How the Body Processes Midazolam and S-warfarin (Pharmacokinetics) Not yet recruiting NCT03291288 Phase 1 S-warfarin;Midazolam;Pexidartinib
10 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088

Search NIH Clinical Center for Tenosynovial Giant Cell Tumor

Genetic Tests for Tenosynovial Giant Cell Tumor

Anatomical Context for Tenosynovial Giant Cell Tumor

MalaCards organs/tissues related to Tenosynovial Giant Cell Tumor:

38
Bone, Salivary Gland, Brain

Publications for Tenosynovial Giant Cell Tumor

Articles related to Tenosynovial Giant Cell Tumor:

(show top 50) (show all 83)
# Title Authors Year
1
Extra-articular tenosynovial giant cell tumor of diffuse type in the temporal area with brain parenchymal invasion: a case report. ( 29334779 )
2018
2
Extra-articular diffuse-type tenosynovial giant cell tumor with benign histological features resulting in fatal pulmonary metastases. ( 28219303 )
2017
3
Tenosynovial Giant Cell Tumor in the Midfoot Treated With Femoral Head Allograft Reconstruction. ( 28864387 )
2017
4
Pitfalls in the cytological diagnosis of tenosynovial giant cell tumor: An illustration of eight discordant cases. ( 28941190 )
2017
5
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
6
Prognosis of Advanced Tenosynovial Giant Cell Tumor of the Knee Diagnosed During Total Knee Arthroplasty. ( 28161138 )
2017
7
Fine needle aspiration cytology diagnosis of metastatic malignant diffuse type tenosynovial giant cell tumor. ( 28701836 )
2017
8
Tenosynovial Giant Cell Tumor: Incidence, Prevalence, Patient Characteristics, and Recurrence. A Registry-based Cohort Study in Denmark. ( 28765257 )
2017
9
Imaging features for diffuse-type tenosynovial giant cell tumor of the temporomandibular joint: A case report. ( 28658169 )
2017
10
Chondroid Tenosynovial Giant Cell Tumor of the Temporomandibular Joint: A Rare Case Report. ( 29215692 )
2017
11
Diffuse Type Tenosynovial Giant Cell Tumor of the Ankle. ( 26996490 )
2016
12
Intramuscular Tenosynovial Giant Cell Tumor, Diffuse-Type. ( 26755356 )
2016
13
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. ( 26820289 )
2016
14
Malignant tenosynovial giant cell tumor with CDKN2A/B genomic alteration: a histological, immunohistochemical, and molecular study. ( 27989786 )
2016
15
Tenosynovial Giant Cell Tumor in the Dermis of the External Auditory Meatus. ( 27072732 )
2016
16
Pediatric Intra-Articular Localized Tenosynovial Giant Cell Tumor Presenting as an Acutely Irritable Hip: A Case Report. ( 29252637 )
2016
17
Coexisting sarcoidal granulomatous inflammation and diffuse tenosynovial giant cell tumor of the knee after a total knee replacement: a case report. ( 27717976 )
2016
18
Tenosynovial giant cell tumor arising from the posterior cruciate ligament: a case report and literature review. ( 26261570 )
2015
19
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. ( 26337311 )
2015
20
Tenosynovial Giant Cell Tumor, Diffuse Type/Pigmented Villonodular Synovitis in a Pars Defect: A Case Report. ( 26067150 )
2015
21
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. ( 26222558 )
2015
22
Malignant tenosynovial giant cell tumor of the leg: a radiologic-pathologic correlation and review of the literature. ( 25861547 )
2015
23
Fine Needle Aspiration Cytology of Chondroid Tenosynovial Giant Cell Tumor of the Hand. ( 26266013 )
2015
24
Arthroscopic Resection of a Tenosynovial Giant Cell Tumor in the Wrist: A Case Report. ( 26496348 )
2015
25
Tenosynovial Giant Cell Tumor of Diffuse Type Mimicking Bony Metastasis Detected on F-18 FDG PET/CT. ( 25177381 )
2014
26
Primary diffuse-type tenosynovial giant cell tumor of the spine: a report of 3 cases and systemic review of the literature. ( 25269059 )
2014
27
Multiple metastases from histologically benign intraarticular diffuse-type tenosynovial giant cell tumor: a case report. ( 25130396 )
2014
28
Hepatoid tenosynovial giant cell tumor - A rare morphologic variant case report. ( 25023880 )
2014
29
Tenosynovial giant cell tumor presenting as a parotid gland mass: Expanding the differential diagnosis of giant cell-rich lesions in salivary glands. ( 25745294 )
2014
30
Diffuse-type tenosynovial giant cell tumor with t(1;17)(p13;p13) and trisomy 5. ( 25189912 )
2014
31
Intramuscular diffuse-type tenosynovial giant cell tumor of the deltoid muscle in a child. ( 24676801 )
2014
32
Novel CSF1-S100A10 fusion gene and CSF1 transcript identified by RNA sequencing in tenosynovial giant cell tumors. ( 24604026 )
2014
33
Recurrent temporal bone tenosynovial giant cell tumor with chondroid metaplasia: the use of imaging to assess recurrence. ( 24571839 )
2014
34
A tenosynovial giant cell tumor arising from femoral attachment of the anterior cruciate ligament. ( 24900909 )
2014
35
Tenosynovial giant cell tumor arising on the scapular region. ( 24403889 )
2013
36
Tenosynovial giant cell tumor in an unusual localization. ( 23619549 )
2013
37
Chondroid tenosynovial giant cell tumor of the temporal bone. ( 23303171 )
2013
38
Partial response of a rare malignant metastatic diffuse tenosynovial giant cell tumor with benign histologic features, treated with SCH 717-454, an insulin growth factor receptor inhibitor, in combination with everolimus, an MTOR inhibitor. ( 23430345 )
2013
39
Navigation-guided resection for a tenosynovial giant cell tumor involving the temporomandibular joint and skull base. ( 22421861 )
2012
40
Malignant diffuse-type tenosynovial giant cell tumor of the buttock. ( 22827766 )
2012
41
Tenosynovial giant cell tumor in the cervico-thoracic junction. ( 23208911 )
2012
42
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. ( 22784912 )
2012
43
Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery. ( 22281719 )
2012
44
Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. ( 21823110 )
2012
45
Tenosynovial giant cell tumor: case report and review. ( 22849738 )
2012
46
Bilateral tenosynovial giant cell tumor of the knee accompanied by chronic ACL tear. ( 21590297 )
2012
47
Chondroid tenosynovial giant cell tumor: a clinicopathological and immunohistochemical analysis of 5 new cases. ( 21087985 )
2011
48
Tenosynovial giant cell tumor of the thigh: positron emission tomography findings. ( 21869945 )
2011
49
Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. ( 21577109 )
2011
50
Localized tenosynovial giant cell tumor in both knee joints. ( 20354849 )
2010

Variations for Tenosynovial Giant Cell Tumor

Expression for Tenosynovial Giant Cell Tumor

Search GEO for disease gene expression data for Tenosynovial Giant Cell Tumor.

Pathways for Tenosynovial Giant Cell Tumor

GO Terms for Tenosynovial Giant Cell Tumor

Cellular components related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CSF1-CSF1R complex GO:1990682 8.62 CSF1 CSF1R

Biological processes related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.61 CLU CSF1 CSF1R
2 negative regulation of cell proliferation GO:0008285 9.54 CDKN2A CDKN2B CSF1R
3 positive regulation of gene expression GO:0010628 9.5 CDKN2A CLU CSF1
4 hemopoiesis GO:0030097 9.4 CSF1 CSF1R
5 osteoclast differentiation GO:0030316 9.26 CSF1 CSF1R
6 negative regulation of phosphorylation GO:0042326 9.16 CDKN2A CDKN2B
7 macrophage differentiation GO:0030225 8.96 CSF1 CSF1R
8 macrophage colony-stimulating factor signaling pathway GO:0038145 8.62 CSF1 CSF1R

Molecular functions related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN2A CDKN2B

Sources for Tenosynovial Giant Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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