MCID: TNS001
MIFTS: 46

Tenosynovial Giant Cell Tumor malady

Cancer diseases, Muscle diseases categories

Summaries for Tenosynovial Giant Cell Tumor

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34MalaCards
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MalaCards: Tenosynovial Giant Cell Tumor, also known as fibrous histiocytoma of tendon sheath, is related to giant cell tumor and hemangioma. An important gene associated with Tenosynovial Giant Cell Tumor is CSF1 (colony stimulating factor 1 (macrophage)), and among its related pathways are ATF-2 transcription factor network and Id Signaling Pathway. The compounds hpvs and eb 1089 have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are vision/eye and skeleton.

Aliases & Classifications for Tenosynovial Giant Cell Tumor

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9Disease Ontology, 63UMLS, 28ICD9CM, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Muscle diseases


Aliases & Descriptions:

tenosynovial giant cell tumor 9
fibrous histiocytoma of tendon sheath 9 63
giant cell tumor of tendon sheath 9
giant cell tumor of tenosynovium 9


External Ids:

Disease Ontology9 DOID:314
ICD9CM28 727.02
NCIt41 C3402

Related Diseases for Tenosynovial Giant Cell Tumor

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Tenosynovial Giant Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1giant cell tumor31.8DES, CSF1
2hemangioma30.8CLU, NF1
3fibroma30.7CALB2, DES
4pigmented villonodular synovitis10.8
5villonodular synovitis10.8
6synovitis10.8
7sclerosing hemangioma10.6
8nodular tenosynovitis10.5
9carpal tunnel syndrome10.4
10wegener's granulomatosis10.4
11bone giant cell tumor10.4
12malignant giant cell tumor10.4
13pyogenic granuloma10.4
14neurofibromatosis10.3
15arthritis10.3
16cervicitis10.3
17rheumatoid arthritis10.3
18adenomatoid tumor10.1CALB2
19actinic keratosis10.1TP53
20adenosarcoma10.1DES
21glomus tumor10.1DES
22sertoli cell tumor10.1CALB2, DES
23granular cell tumor10.1DES, CALB2
24benign mesothelioma10.1CALB2, TP53
25sex cord-gonadal stromal tumor10.1CALB2, DES
26endometrial stromal sarcoma10.1CSF1, DES
27pseudosarcomatous fibromatosis10.1DES, MYOG
28alveolar soft part sarcoma10.1MYOG, DES
29alveolar rhabdomyosarcoma10.1DES, MYOG
30myopathy congenital10.1MYOG, DES
31embryonal rhabdomyosarcoma10.1MYOG, DES
32abrikosov's tumor10.1DES, CALB2
33adrenocortical carcinoma10.0CALB2, TP53
34smooth muscle tumor10.0DES, CCNA2
35malignant mixed mullerian tumor10.0TP53, DES
36meningioma10.0NF1, CALB2
37uterine fibroid10.0MYOG, DES
38wilms tumor10.0DES, MYOG, CALB2
39chronic myelomonocytic leukemia10.0NF1, CSF1
40laryngeal squamous cell carcinoma10.0CCNA2, TP53
41malignant fibroxanthoma10.0MYOG, DES, CCNA2
42malignant mesothelioma10.0DES, CALB2
43anaplastic astrocytoma10.0CCNA2, TP53
44lung small cell carcinoma10.0CCNA2, TP53, CALB2
45liposarcoma10.0DES, TP53, CALB2
46leiomyoma10.0DES, MYOG
47li-fraumeni syndrome10.0TP53, NF1
48myopathy10.0COL6A3, MYOG, DES
49epilepsy syndrome10.0CALB2, CLU, CCNA2
50seminoma10.0CCNA2, CALB2

Graphical network of the top 20 diseases related to Tenosynovial Giant Cell Tumor:



Diseases related to tenosynovial giant cell tumor

Symptoms for Tenosynovial Giant Cell Tumor

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Drugs & Therapeutics for Tenosynovial Giant Cell Tumor

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Tenosynovial Giant Cell Tumor

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Anatomical Context for Tenosynovial Giant Cell Tumor

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34MalaCards
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MalaCards organs/tissues related to Tenosynovial Giant Cell Tumor:

34
Bone

Animal Models for Tenosynovial Giant Cell Tumor or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Tenosynovial Giant Cell Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6NF1, CSF1, COL6A3, TP53
2MP:00053908.2TP53, MYOG, COL6A3, CSF1, NF1
3MP:00053888.2TP53, MYOG, CSF1, NF1
4MP:00053858.1DES, TP53, CLU, CSF1, NF1
5MP:00053767.7DES, TP53, CLU, MYOG, CSF1, NF1
6MP:00107687.6DES, TP53, MYOG, CCNA2, CSF1, NF1
7MP:00053697.4NF1, DES, TP53, CLU, MYOG, COL6A3
8MP:00053867.4DES, TP53, MYOG, CSF1, CALB2, NF1

Publications for Tenosynovial Giant Cell Tumor

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53PubMed
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Articles related to Tenosynovial Giant Cell Tumor:

(show all 49)
idTitleAuthorsYear
1
Partial response of a rare malignant metastatic diffuse tenosynovial giant cell tumor with benign histologic features, treated with SCH 717-454, an insulin growth factor receptor inhibitor, in combination with everolimus, an MTOR inhibitor. (23430345)
2013
2
Tenosynovial giant cell tumor in an unusual localization. (23619549)
2013
3
Tenosynovial giant cell tumor arising on the scapular region. (24403889)
2013
4
Chondroid tenosynovial giant cell tumor of the temporal bone. (23303171)
2013
5
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. (22784912)
2012
6
Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery. (22281719)
2012
7
Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. (21823110)
2012
8
Tenosynovial giant cell tumor in the cervico-thoracic junction. (23208911)
2012
9
Bilateral tenosynovial giant cell tumor of the knee accompanied by chronic ACL tear. (21590297)
2012
10
Tenosynovial giant cell tumor: case report and review. (22849738)
2012
11
Malignant diffuse-type tenosynovial giant cell tumor of the buttock. (22827766)
2012
12
Navigation-guided resection for a tenosynovial giant cell tumor involving the temporomandibular joint and skull base. (22421861)
2012
13
Tenosynovial giant cell tumor of the thigh: positron emission tomography findings. (21869945)
2011
14
Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. (21577109)
2011
15
Chondroid tenosynovial giant cell tumor: a clinicopathological and immunohistochemical analysis of 5 new cases. (21087985)
2011
16
Localized tenosynovial giant cell tumor in both knee joints. (20354849)
2010
17
Therapeutic Antibodies Targeting CSF1 Impede Macrophage Recruitment in a Xenograft Model of Tenosynovial Giant Cell Tumor. (20981142)
2010
18
Clusterin is expressed in normal synoviocytes and in tenosynovial giant cell tumors of localized and diffuse types: diagnostic and histogenetic implications. (19542874)
2009
19
Yellow nodule on the distal finger. Xanthomatous localized tenosynovial giant cell tumor (TGCT) of the finger. (19687429)
2009
20
Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT). (18296418)
2008
21
Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors. (17918257)
2008
22
Tenosynovial giant cell tumor of the posterior arch of C1. (18309482)
2008
23
Immunohistochemical and biogenetic features of diffuse-type tenosynovial giant cell tumors: the potential roles of cyclin A, P53, and deletion of 15q in sarcomatous transformation. (18829481)
2008
24
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
25
Tenosynovial giant cell tumor and pigmented villonodular synovitis. (17579851)
2007
26
Translocation and expression of CSF1 in pigmented villonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides. (17527089)
2007
27
Atypical tenosynovial giant cell tumor of the extensor hallucis longus tendon. (16868332)
2006
28
Diffuse-type tenosynovial giant cell tumor in association with neurofibromatosis type 1-Noonan syndrome: possibly more than a chance relationship. (16723851)
2006
29
A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. (16407111)
2006
30
Conditions suggesting lymphoma: case 3. Primary synovial lymphoma with osteoclast-like giant cells presenting as a tenosynovial giant-cell tumor. (15923579)
2005
31
Tenosynovial giant cell tumor]. (15657685)
2005
32
A large, multiply recurrent tenosynovial giant cell tumor of the hand treated with resection and radiation therapy. (15074461)
2004
33
Arthroscopic resection of an extra-articular tenosynovial giant cell tumor from the ankle region. (12966401)
2003
34
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
35
Localized tenosynovial giant cell tumor of tendon sheath. A case report. (10834013)
2000
36
Tenosynovial giant cell tumor of finger, localized type: a case report. (10642950)
1999
37
Analysis of 35 cases of localized and diffuse tenosynovial giant cell tumor: a report from the Chromosomes and Morphology (CHAMP) study group. (10392632)
1999
38
Diffuse variant tenosynovial giant cell tumor of the temporomandibular joint: report of a case. (9710197)
1998
39
Tenosynovial giant cell tumors: evidence for a desmin-positive dendritic cell subpopulation. (9796719)
1998
40
A new cytogenetic subgroup in tenosynovial giant cell tumors (nodular tenosynovitis) is characterized by involvement of 16q24. (8646750)
1996
41
Tenosynovial giant-cell tumor arising from the anterior cruciate ligament of the knee. (8864010)
1996
42
Tenosynovial giant-cell tumor in the knee joint. (7794435)
1995
43
Diffuse tenosynovial giant cell tumor of soft tissues. Report of a case with cytologic and cytogenetic findings. (7631554)
1995
44
Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis). (8033128)
1994
45
Diffuse-variant tenosynovial giant cell tumor: a rare and aggressive lesion. (8163276)
1994
46
Scintigraphic evaluation of tenosynovial giant-cell tumor using technetium-99m(V)-dimercaptosuccinic acid. (8410292)
1993
47
Diffuse type tenosynovial giant cell tumor of the ankle. (8386232)
1993
48
Tenosynovial giant-cell tumor of the cervical spine. Case report. (1331365)
1992
49
Diffuse and localized tenosynovial giant cell tumor and pigmented villonodular synovitis: a clinicopathologic and flow cytometric DNA analysis. (1319390)
1992

Variations for Tenosynovial Giant Cell Tumor

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Expression for genes affiliated with Tenosynovial Giant Cell Tumor

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tenosynovial Giant Cell Tumor

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Pathways for genes affiliated with Tenosynovial Giant Cell Tumor

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51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 58SinoBiological, 54QIAGEN, 31KEGG
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Pathways related to Tenosynovial Giant Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6NF1, CCNA2
29.6CCNA2, MYOG
39.5CCNA2, TP53
49.5CCNA2, TP53
5
Show member pathways
p53 pathway39
9.5CCNA2, TP53
69.5TP53, CCNA2
79.2TP53, COL6A3, CSF1
8
Show member pathways
8.2NF1, CSF1, COL6A3, TP53, DES

Compounds for genes affiliated with Tenosynovial Giant Cell Tumor

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Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 52PharmGKB, 3BitterDB, 30IUPHAR, 25HMDB
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Compounds related to Tenosynovial Giant Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1hpvs469.7CCNA2, TP53
2eb 108946 6210.7CCNA2, CLU
3olomoucine46 1210.6CCNA2, TP53
4hydroxyurea46 52 1211.5TP53, CCNA2, CSF1
5colchicine46 62 3 30 1213.5CLU, CCNA2, NF1
6hmba469.5CCNA2, TP53
7cytarabine46 52 1211.5TP53, CCNA2, CSF1
8adpribose469.4CCNA2, TP53, DES
9bromodeoxyuridine469.4DES, MYOG, CCNA2
10bcnu469.4TP53, CSF1
11mucicarmine469.4DES, CALB2
12c2ceramide469.4CSF1, MYOG, TP53
13arsenite46 2510.4CSF1, CCNA2, TP53
145fluorouracil469.3CSF1, CCNA2, TP53
15camptothecin46 62 1211.3CCNA2, CLU, TP53
16docetaxel46 52 62 1212.3TP53, CLU, CCNA2
1712-o-tetradecanoylphorbol 13-acetate469.3DES, MYOG, CCNA2, CSF1
18lysine469.2DES, CCNA2, CSF1, NF1
19rapamycin469.2MYOG, CCNA2, CSF1, NF1
20etoposide46 52 62 1212.1CSF1, CCNA2, CLU, TP53
21cisplatin46 52 62 1212.0CSF1, CCNA2, CLU, TP53
22ly294002469.0TP53, MYOG, CCNA2, CSF1
23actinomycin d469.0CSF1, CLU, TP53, DES
24proline469.0DES, TP53, CLU, CCNA2
25cycloheximide469.0CSF1, CCNA2, CLU, TP53
26fatty acid468.9NF1, MYOG, CLU, DES
27ethanol46 52 25 1211.8CALB2, CCNA2, CLU, DES
28acetylcholine46 52 30 25 1212.8DES, MYOG, CSF1, CALB2
29n acetylcysteine468.8CSF1, CLU, TP53
30adenylate468.8DES, MYOG, CCNA2, CSF1, NF1
31doxorubicin46 52 1210.7DES, TP53, CLU, CCNA2, CSF1
32h2o2468.7CSF1, CCNA2, CLU, TP53, DES
33arginine468.7DES, TP53, CCNA2, CSF1, NF1
34dopamine46 30 25 1211.7CLU, CCNA2, CALB2, NF1
35cysteine468.6NF1, CSF1, MYOG, CLU, DES
36nitric oxide46 25 1210.4DES, MYOG, CCNA2, CALB2
37oligonucleotide468.4TP53, CLU, MYOG, CCNA2, NF1
38paclitaxel46 52 1210.3TP53, CLU, CCNA2, CSF1, CALB2
39vegf468.2DES, TP53, CLU, MYOG, CCNA2, CSF1
40testosterone46 62 25 1211.0DES, CLU, MYOG, CCNA2, CSF1, CALB2
41thymidine46 258.9DES, TP53, CLU, CCNA2, CSF1, CALB2
42steroid467.8DES, CLU, MYOG, CCNA2, CALB2, NF1
43butyrate467.8TP53, CLU, MYOG, CCNA2, CSF1, CALB2
44retinoic acid46 258.7DES, TP53, CLU, MYOG, CCNA2, CSF1
45serine467.7DES, TP53, CLU, MYOG, CCNA2, CSF1
46calcium46 52 25 1210.7DES, CLU, MYOG, CCNA2, CALB2, NF1
47tyrosine467.5DES, CLU, MYOG, CCNA2, CSF1, CALB2
48progesterone46 30 62 25 1211.4DES, TP53, CLU, CCNA2, CSF1, CALB2
49paraffin466.9NF1, DES, TP53, CLU, MYOG, CCNA2
50estrogen466.9DES, TP53, CLU, MYOG, CCNA2, CSF1

GO Terms for genes affiliated with Tenosynovial Giant Cell Tumor

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17Gene Ontology
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Cellular components related to Tenosynovial Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcolemmaGO:0423839.7COL6A3, DES

Biological processes related to Tenosynovial Giant Cell Tumor according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1ossificationGO:0015039.6CSF1, MYOG
2release of cytochrome c from mitochondriaGO:0018369.6CLU, TP53
3negative regulation of neuroblast proliferationGO:0074069.6NF1, TP53
4positive regulation of cell cycle arrestGO:0711589.5TP53, MYOG
5positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.5TP53, CLU
6negative regulation of fibroblast proliferationGO:0481479.5NF1, TP53
7positive regulation of neuron apoptotic processGO:0435259.3NF1, TP53
8skeletal muscle tissue developmentGO:0075199.3MYOG, NF1
9Ras protein signal transductionGO:0072659.2NF1, CCNA2, TP53
10intrinsic apoptotic signaling pathwayGO:0971939.1CLU, TP53
11positive regulation of apoptotic processGO:0430658.9NF1, CLU, TP53

Molecular functions related to Tenosynovial Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0012289.3MYOG, TP53

Products for genes affiliated with Tenosynovial Giant Cell Tumor

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Sources for Tenosynovial Giant Cell Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet