MCID: TNS001
MIFTS: 40

Tenosynovial Giant Cell Tumor malady

Muscle diseases, Cancer diseases categories

Summaries for Tenosynovial Giant Cell Tumor

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MalaCards based summary: Tenosynovial Giant Cell Tumor, also known as fibrous histiocytoma of tendon sheath, is related to giant cell tumor and fibroma. An important gene associated with Tenosynovial Giant Cell Tumor is CSF1 (colony stimulating factor 1 (macrophage)), and among its related pathways are ATF-2 transcription factor network and Id Signaling Pathway. The compounds hpvs and eb 1089 have been mentioned in the context of this disorder. Affiliated tissues include bone and salivary gland, and related mouse phenotypes are vision/eye and skeleton.

Aliases & Classifications for Tenosynovial Giant Cell Tumor

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Tenosynovial Giant Cell Tumor, Aliases & Descriptions:

Name: Tenosynovial Giant Cell Tumor 9
Fibrous Histiocytoma of Tendon Sheath 9 60
 
Giant Cell Tumor of Tendon Sheath 9
Giant Cell Tumor of Tenosynovium 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Muscle diseases


External Ids:

Disease Ontology9 DOID:314
NCIt38 C3402
ICD9CM27 727.02

Related Diseases for Tenosynovial Giant Cell Tumor

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Diseases related to Tenosynovial Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1giant cell tumor32.2DES, CSF1
2fibroma31.0CALB2, DES
3hemangioma30.7CLU, NF1
4pigmented villonodular synovitis10.9
5villonodular synovitis10.8
6synovitis10.8
7sclerosing hemangioma10.6
8adenomatoid tumor10.5CALB2
9nodular tenosynovitis10.5
10actinic keratosis10.4TP53
11adenosarcoma10.4DES
12bone giant cell tumor10.4
13malignant giant cell tumor10.4
14pyogenic granuloma10.4
15glomus tumor10.4DES
16rheumatoid arthritis10.3
17arthritis10.3
18malignant giant cell tumor of the tendon sheath10.3
19neurofibromatosis10.3
20cervicitis10.3
21sertoli cell tumor10.3CALB2, DES
22granular cell tumor10.3DES, CALB2
23benign mesothelioma10.3CALB2, TP53
24myoma10.3MYOG, DES
25sex cord-gonadal stromal tumor10.3CALB2, DES
26endometrial stromal sarcoma10.3CSF1, DES
27pseudosarcomatous fibromatosis10.3DES, MYOG
28alveolar soft-part sarcoma10.3MYOG, DES
29rhabdomyosarcoma 2, alveolar10.2DES, MYOG
30myopathy congenital10.2MYOG, DES
31embryonal rhabdomyosarcoma10.2MYOG, DES
32abrikosov's tumor10.2DES, CALB2
33adrenocortical carcinoma10.2CALB2, TP53
34smooth muscle tumor10.2DES, CCNA2
35malignant mixed mullerian tumor10.2TP53, DES
36meningioma, familial10.2NF1, CALB2
37uterine fibroid10.2MYOG, DES
38mesothelioma10.1DES, MYOG, CALB2
39wilms tumor10.1DES, MYOG, CALB2
40chronic myelomonocytic leukemia10.1NF1, CSF1
41laryngeal squamous cell carcinoma10.1CCNA2, TP53
42malignant fibroxanthoma10.1MYOG, DES, CCNA2
43mesothelioma, somatic10.1DES, CALB2
44grade iii astrocytoma10.1CCNA2, TP53
45liposarcoma10.1DES, TP53, CALB2
46leiomyoma10.1DES, MYOG
47small cell cancer of the lung, somatic10.1CCNA2, TP53, CALB2
48li-fraumeni syndrome10.1TP53, NF1
49myopathy10.0COL6A3, MYOG, DES
50epilepsy syndrome10.0CALB2, CLU, CCNA2

Graphical network of the top 20 diseases related to Tenosynovial Giant Cell Tumor:



Diseases related to tenosynovial giant cell tumor

Symptoms for Tenosynovial Giant Cell Tumor

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Drugs & Therapeutics for Tenosynovial Giant Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Tenosynovial Giant Cell Tumor

Search NIH Clinical Center for Tenosynovial Giant Cell Tumor

Genetic Tests for Tenosynovial Giant Cell Tumor

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Anatomical Context for Tenosynovial Giant Cell Tumor

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MalaCards organs/tissues related to Tenosynovial Giant Cell Tumor:

31
Bone, Salivary gland

Animal Models for Tenosynovial Giant Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Tenosynovial Giant Cell Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6NF1, CSF1, COL6A3, TP53
2MP:00053908.2TP53, MYOG, COL6A3, CSF1, NF1
3MP:00053888.2TP53, MYOG, CSF1, NF1
4MP:00053858.1DES, TP53, CLU, CSF1, NF1
5MP:00053767.7DES, TP53, CLU, MYOG, CSF1, NF1
6MP:00107687.6DES, TP53, MYOG, CCNA2, CSF1, NF1
7MP:00053697.4NF1, DES, TP53, CLU, MYOG, COL6A3
8MP:00053867.4DES, TP53, MYOG, CSF1, CALB2, NF1

Publications for Tenosynovial Giant Cell Tumor

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Articles related to Tenosynovial Giant Cell Tumor:

(show top 50)    (show all 59)
idTitleAuthorsYear
1
Malignant tenosynovial giant cell tumor of the leg: a radiologic-pathologic correlation and review of the literature. (25861547)
2015
2
Tenosynovial Giant Cell Tumor of Diffuse Type Mimicking Bony Metastasis Detected on F-18 FDG PET/CT. (25177381)
2014
3
Diffuse-type tenosynovial giant cell tumor with t(1;17)(p13;p13) and trisomy 5. (25189912)
2014
4
Intramuscular diffuse-type tenosynovial giant cell tumor of the deltoid muscle in a child. (24676801)
2014
5
Recurrent temporal bone tenosynovial giant cell tumor with chondroid metaplasia: the use of imaging to assess recurrence. (24571839)
2014
6
A tenosynovial giant cell tumor arising from femoral attachment of the anterior cruciate ligament. (24900909)
2014
7
Partial response of a rare malignant metastatic diffuse tenosynovial giant cell tumor with benign histologic features, treated with SCH 717-454, an insulin growth factor receptor inhibitor, in combination with everolimus, an MTOR inhibitor. (23430345)
2013
8
Tenosynovial giant cell tumor in an unusual localization. (23619549)
2013
9
Tenosynovial giant cell tumor arising on the scapular region. (24403889)
2013
10
Chondroid tenosynovial giant cell tumor of the temporal bone. (23303171)
2013
11
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. (22784912)
2012
12
Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery. (22281719)
2012
13
Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. (21823110)
2012
14
Tenosynovial giant cell tumor in the cervico-thoracic junction. (23208911)
2012
15
Bilateral tenosynovial giant cell tumor of the knee accompanied by chronic ACL tear. (21590297)
2012
16
Tenosynovial giant cell tumor: case report and review. (22849738)
2012
17
Malignant diffuse-type tenosynovial giant cell tumor of the buttock. (22827766)
2012
18
Navigation-guided resection for a tenosynovial giant cell tumor involving the temporomandibular joint and skull base. (22421861)
2012
19
Tenosynovial giant cell tumor of the thigh: positron emission tomography findings. (21869945)
2011
20
Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. (21577109)
2011
21
Chondroid tenosynovial giant cell tumor: a clinicopathological and immunohistochemical analysis of 5 new cases. (21087985)
2011
22
Localized tenosynovial giant cell tumor in both knee joints. (20354849)
2010
23
Therapeutic Antibodies Targeting CSF1 Impede Macrophage Recruitment in a Xenograft Model of Tenosynovial Giant Cell Tumor. (20981142)
2010
24
Clusterin is expressed in normal synoviocytes and in tenosynovial giant cell tumors of localized and diffuse types: diagnostic and histogenetic implications. (19542874)
2009
25
Yellow nodule on the distal finger. Xanthomatous localized tenosynovial giant cell tumor (TGCT) of the finger. (19687429)
2009
26
Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT). (18296418)
2008
27
Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors. (17918257)
2008
28
Tenosynovial giant cell tumor of the posterior arch of C1. (18309482)
2008
29
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
30
Tenosynovial giant cell tumor and pigmented villonodular synovitis. (17579851)
2007
31
Translocation and expression of CSF1 in pigmented villonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides. (17527089)
2007
32
Atypical tenosynovial giant cell tumor of the extensor hallucis longus tendon. (16868332)
2006
33
Diffuse-type tenosynovial giant cell tumor in association with neurofibromatosis type 1-Noonan syndrome: possibly more than a chance relationship. (16723851)
2006
34
A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. (16407111)
2006
35
Conditions suggesting lymphoma: case 3. Primary synovial lymphoma with osteoclast-like giant cells presenting as a tenosynovial giant-cell tumor. (15923579)
2005
36
A large, multiply recurrent tenosynovial giant cell tumor of the hand treated with resection and radiation therapy. (15074461)
2004
37
Arthroscopic resection of an extra-articular tenosynovial giant cell tumor from the ankle region. (12966401)
2003
38
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
39
Localized tenosynovial giant cell tumor of tendon sheath. A case report. (10834013)
2000
40
Tenosynovial giant cell tumor of finger, localized type: a case report. (10642950)
1999
41
Analysis of 35 cases of localized and diffuse tenosynovial giant cell tumor: a report from the Chromosomes and Morphology (CHAMP) study group. (10392632)
1999
42
Diffuse variant tenosynovial giant cell tumor of the temporomandibular joint: report of a case. (9710197)
1998
43
Tenosynovial giant cell tumors: evidence for a desmin-positive dendritic cell subpopulation. (9796719)
1998
44
A new cytogenetic subgroup in tenosynovial giant cell tumors (nodular tenosynovitis) is characterized by involvement of 16q24. (8646750)
1996
45
Tenosynovial giant-cell tumor in the knee joint. (7794435)
1995
46
Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis). (8033128)
1994
47
Diffuse-variant tenosynovial giant cell tumor: a rare and aggressive lesion. (8163276)
1994
48
Scintigraphic evaluation of tenosynovial giant-cell tumor using technetium-99m(V)-dimercaptosuccinic acid. (8410292)
1993
49
Tenosynovial giant-cell tumor of the cervical spine. Case report. (1331365)
1992
50
Diffuse and localized tenosynovial giant cell tumor and pigmented villonodular synovitis: a clinicopathologic and flow cytometric DNA analysis. (1319390)
1992

Variations for Tenosynovial Giant Cell Tumor

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Expression for genes affiliated with Tenosynovial Giant Cell Tumor

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Search GEO for disease gene expression data for Tenosynovial Giant Cell Tumor.

Pathways for genes affiliated with Tenosynovial Giant Cell Tumor

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Pathways related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6NF1, CCNA2
29.6CCNA2, MYOG
39.5CCNA2, TP53
49.5CCNA2, TP53
5
Show member pathways
p53 pathway36
9.5CCNA2, TP53
69.5TP53, CCNA2
79.2TP53, COL6A3, CSF1
8
Show member pathways
8.2NF1, CSF1, COL6A3, TP53, DES

Compounds for genes affiliated with Tenosynovial Giant Cell Tumor

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Compounds related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1hpvs439.7CCNA2, TP53
2eb 108943 5910.7CCNA2, CLU
3olomoucine43 1210.6TP53, CCNA2
4hydroxyurea43 49 1211.5CSF1, TP53, CCNA2
5colchicine43 59 2 28 1213.5CLU, NF1, CCNA2
6hmba439.5TP53, CCNA2
7cytarabine43 49 1211.5CSF1, CCNA2, TP53
8adpribose439.4DES, CCNA2, TP53
9bromodeoxyuridine439.4DES, MYOG, CCNA2
10bcnu439.4TP53, CSF1
11mucicarmine439.4DES, CALB2
12c2ceramide439.4MYOG, CSF1, TP53
13arsenite43 2410.4TP53, CSF1, CCNA2
145fluorouracil439.3TP53, CCNA2, CSF1
15camptothecin43 59 1211.3CLU, CCNA2, TP53
16docetaxel43 49 59 1212.3TP53, CCNA2, CLU
1712-o-tetradecanoylphorbol 13-acetate439.3CCNA2, MYOG, DES, CSF1
18lysine439.2DES, CSF1, NF1, CCNA2
19rapamycin439.2CCNA2, CSF1, NF1, MYOG
20etoposide43 49 59 1212.1TP53, CSF1, CLU, CCNA2
21cisplatin43 49 59 1212.0TP53, CCNA2, CSF1, CLU
22ly294002439.0TP53, MYOG, CCNA2, CSF1
23actinomycin d439.0CLU, CSF1, TP53, DES
24proline439.0CCNA2, DES, CLU, TP53
25cycloheximide439.0TP53, CLU, CCNA2, CSF1
26fatty acid438.9DES, CLU, NF1, MYOG
27ethanol43 49 24 1211.8CCNA2, CLU, CALB2, DES
28acetylcholine43 49 28 24 1212.8CSF1, CALB2, MYOG, DES
29n acetylcysteine438.8CLU, TP53, CSF1
30adenylate438.8CSF1, NF1, DES, CCNA2, MYOG
31doxorubicin43 49 1210.7DES, TP53, CLU, CCNA2, CSF1
32h2o2438.7CCNA2, CSF1, CLU, TP53, DES
33arginine438.7CCNA2, TP53, DES, CSF1, NF1
34dopamine43 28 24 1211.7CCNA2, CLU, CALB2, NF1
35cysteine438.6DES, MYOG, CSF1, NF1, CLU
36nitric oxide43 24 1210.4CCNA2, CALB2, DES, MYOG
37oligonucleotide438.4TP53, CLU, CCNA2, MYOG, NF1
38paclitaxel43 49 1210.3CLU, CSF1, CALB2, TP53, CCNA2
39vegf438.2CCNA2, MYOG, CLU, TP53, DES, CSF1
40testosterone43 59 24 1211.0CALB2, CSF1, DES, CLU, MYOG, CCNA2
41thymidine43 248.9DES, TP53, CLU, CCNA2, CALB2, CSF1
42steroid437.8NF1, CALB2, CCNA2, MYOG, CLU, DES
43butyrate437.8TP53, CCNA2, CSF1, CALB2, MYOG, CLU
44retinoic acid43 248.7TP53, CLU, MYOG, CCNA2, CSF1, NF1
45serine437.7CSF1, CCNA2, MYOG, CLU, TP53, NF1
46calcium43 49 24 1210.7DES, CLU, CCNA2, CALB2, NF1, MYOG
47tyrosine437.5NF1, DES, CLU, MYOG, CCNA2, CSF1
48progesterone43 28 59 24 1211.4CALB2, CSF1, CCNA2, NF1, CLU, TP53
49paraffin436.9CCNA2, DES, TP53, CLU, MYOG, NF1
50estrogen436.9CCNA2, CSF1, CALB2, CLU, NF1, TP53

GO Terms for genes affiliated with Tenosynovial Giant Cell Tumor

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Cellular components related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sarcolemmaGO:00423839.7COL6A3, DES

Biological processes related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1ossificationGO:00015039.6CSF1, MYOG
2release of cytochrome c from mitochondriaGO:00018369.6CLU, TP53
3negative regulation of neuroblast proliferationGO:00074069.6NF1, TP53
4positive regulation of cell cycle arrestGO:00711589.5TP53, MYOG
5positive regulation of intrinsic apoptotic signaling pathwayGO:020012449.5TP53, CLU
6negative regulation of fibroblast proliferationGO:00481479.5NF1, TP53
7positive regulation of neuron apoptotic processGO:00435259.3NF1, TP53
8skeletal muscle tissue developmentGO:00075199.3MYOG, NF1
9Ras protein signal transductionGO:00072659.2NF1, CCNA2, TP53
10intrinsic apoptotic signaling pathwayGO:00971939.1CLU, TP53
11positive regulation of apoptotic processGO:00430658.9NF1, CLU, TP53

Molecular functions related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:00012289.3MYOG, TP53

Products for genes affiliated with Tenosynovial Giant Cell Tumor

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Sources for Tenosynovial Giant Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet