MCID: TNS001
MIFTS: 31

Tenosynovial Giant Cell Tumor malady

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Tenosynovial Giant Cell Tumor

About this section

Aliases & Descriptions for Tenosynovial Giant Cell Tumor:

Name: Tenosynovial Giant Cell Tumor 11 13
Fibrous Histiocytoma of Tendon Sheath 11 66
 
Giant Cell Tumor of Tendon Sheath 11
Giant Cell Tumor of Tenosynovium 11

Classifications:



External Ids:

Disease Ontology11 DOID:314
ICD9CM30 727.02
NCIt43 C3402

Summaries for Tenosynovial Giant Cell Tumor

About this section
MalaCards based summary: Tenosynovial Giant Cell Tumor, also known as fibrous histiocytoma of tendon sheath, is related to pigmented villonodular synovitis and giant cell tumor. An important gene associated with Tenosynovial Giant Cell Tumor is CSF1 (Colony Stimulating Factor 1), and among its related pathways are Hematopoietic cell lineage and Macrophage Differentiation and Growth Inhibition by METS. Affiliated tissues include bone and salivary gland.

Related Diseases for Tenosynovial Giant Cell Tumor

About this section

Graphical network of the top 20 diseases related to Tenosynovial Giant Cell Tumor:



Diseases related to tenosynovial giant cell tumor

Symptoms for Tenosynovial Giant Cell Tumor

About this section

Drugs & Therapeutics for Tenosynovial Giant Cell Tumor

About this section

Drugs for Tenosynovial Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PaclitaxelPhase 1269133069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nab-paclitaxel
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel

Interventional clinical trials:

idNameStatusNCT IDPhase
1PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)Active, not recruitingNCT02371369Phase 3
2Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)CompletedNCT01261429Phase 2
3Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell TumorRecruitingNCT02471716Phase 1, Phase 2
4MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)RecruitingNCT01643850Phase 2
5Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell TumorActive, not recruitingNCT01207492Phase 2
6A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell TumorRecruitingNCT02673736Phase 1
7Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid TumorsRecruitingNCT01804530Phase 1
8A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid TumorsActive, not recruitingNCT01494688Phase 1
9Safety Study of PLX108-01 in Patients With Solid TumorsActive, not recruitingNCT01004861Phase 1

Search NIH Clinical Center for Tenosynovial Giant Cell Tumor

Genetic Tests for Tenosynovial Giant Cell Tumor

About this section

Anatomical Context for Tenosynovial Giant Cell Tumor

About this section

MalaCards organs/tissues related to Tenosynovial Giant Cell Tumor:

34
Bone, Salivary gland

Animal Models for Tenosynovial Giant Cell Tumor or affiliated genes

About this section

Publications for Tenosynovial Giant Cell Tumor

About this section

Articles related to Tenosynovial Giant Cell Tumor:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Intramuscular Tenosynovial Giant Cell Tumor, Diffuse-Type. (26755356)
2016
2
Diffuse Type Tenosynovial Giant Cell Tumor of the Ankle. (26996490)
2016
3
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. (26820289)
2016
4
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. (26337311)
2015
5
Malignant tenosynovial giant cell tumor of the leg: a radiologic-pathologic correlation and review of the literature. (25861547)
2015
6
Tenosynovial giant cell tumor arising from the posterior cruciate ligament: a case report and literature review. (26261570)
2015
7
Fine Needle Aspiration Cytology of Chondroid Tenosynovial Giant Cell Tumor of the Hand. (26266013)
2015
8
Arthroscopic Resection of a Tenosynovial Giant Cell Tumor in the Wrist: A Case Report. (26496348)
2015
9
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. (26222558)
2015
10
Tenosynovial Giant Cell Tumor, Diffuse Type/Pigmented Villonodular Synovitis in a Pars Defect: A Case Report. (26067150)
2015
11
Diffuse-type tenosynovial giant cell tumor with t(1;17)(p13;p13) and trisomy 5. (25189912)
2014
12
A tenosynovial giant cell tumor arising from femoral attachment of the anterior cruciate ligament. (24900909)
2014
13
Tenosynovial giant cell tumor presenting as a parotid gland mass: Expanding the differential diagnosis of giant cell-rich lesions in salivary glands. (25745294)
2014
14
Primary diffuse-type tenosynovial giant cell tumor of the spine: a report of 3 cases and systemic review of the literature. (25269059)
2014
15
Tenosynovial Giant Cell Tumor of Diffuse Type Mimicking Bony Metastasis Detected on F-18 FDG PET/CT. (25177381)
2014
16
Partial response of a rare malignant metastatic diffuse tenosynovial giant cell tumor with benign histologic features, treated with SCH 717-454, an insulin growth factor receptor inhibitor, in combination with everolimus, an MTOR inhibitor. (23430345)
2013
17
Chondroid tenosynovial giant cell tumor of the temporal bone. (23303171)
2013
18
Tenosynovial giant cell tumor in an unusual localization. (23619549)
2013
19
Malignant diffuse-type tenosynovial giant cell tumor of the buttock. (22827766)
2012
20
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. (22784912)
2012
21
Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery. (22281719)
2012
22
Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. (21823110)
2012
23
Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. (21577109)
2011
24
Chondroid tenosynovial giant cell tumor: a clinicopathological and immunohistochemical analysis of 5 new cases. (21087985)
2011
25
Tenosynovial giant cell tumor of the thigh: positron emission tomography findings. (21869945)
2011
26
Therapeutic Antibodies Targeting CSF1 Impede Macrophage Recruitment in a Xenograft Model of Tenosynovial Giant Cell Tumor. (20981142)
2010
27
Localized tenosynovial giant cell tumor in both knee joints. (20354849)
2010
28
Yellow nodule on the distal finger. Xanthomatous localized tenosynovial giant cell tumor (TGCT) of the finger. (19687429)
2009
29
Clusterin is expressed in normal synoviocytes and in tenosynovial giant cell tumors of localized and diffuse types: diagnostic and histogenetic implications. (19542874)
2009
30
Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT). (18296418)
2008
31
Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors. (17918257)
2008
32
Tenosynovial giant cell tumor of the posterior arch of C1. (18309482)
2008
33
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
34
Tenosynovial giant cell tumor and pigmented villonodular synovitis. (17579851)
2007
35
Diffuse-type tenosynovial giant cell tumor in association with neurofibromatosis type 1-Noonan syndrome: possibly more than a chance relationship. (16723851)
2006
36
Atypical tenosynovial giant cell tumor of the extensor hallucis longus tendon. (16868332)
2006
37
Conditions suggesting lymphoma: case 3. Primary synovial lymphoma with osteoclast-like giant cells presenting as a tenosynovial giant-cell tumor. (15923579)
2005
38
A large, multiply recurrent tenosynovial giant cell tumor of the hand treated with resection and radiation therapy. (15074461)
2004
39
Arthroscopic resection of an extra-articular tenosynovial giant cell tumor from the ankle region. (12966401)
2003
40
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
41
Localized tenosynovial giant cell tumor of tendon sheath. A case report. (10834013)
2000
42
Tenosynovial giant cell tumor of finger, localized type: a case report. (10642950)
1999
43
Diffuse variant tenosynovial giant cell tumor of the temporomandibular joint: report of a case. (9710197)
1998
44
Tenosynovial giant cell tumors: evidence for a desmin-positive dendritic cell subpopulation. (9796719)
1998
45
Tenosynovial giant-cell tumor arising from the anterior cruciate ligament of the knee. (8864010)
1996
46
Tenosynovial giant-cell tumor in the knee joint. (7794435)
1995
47
Diffuse-variant tenosynovial giant cell tumor: a rare and aggressive lesion. (8163276)
1994
48
Scintigraphic evaluation of tenosynovial giant-cell tumor using technetium-99m(V)-dimercaptosuccinic acid. (8410292)
1993
49
Diffuse type tenosynovial giant cell tumor of the ankle. (8386232)
1993
50
Tenosynovial giant-cell tumor of the cervical spine. Case report. (1331365)
1992

Variations for Tenosynovial Giant Cell Tumor

About this section

Expression for genes affiliated with Tenosynovial Giant Cell Tumor

About this section
Search GEO for disease gene expression data for Tenosynovial Giant Cell Tumor.

Pathways for genes affiliated with Tenosynovial Giant Cell Tumor

About this section

GO Terms for genes affiliated with Tenosynovial Giant Cell Tumor

About this section

Cellular components related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CSF1-CSF1R complexGO:199068210.3CSF1, CSF1R
2platelet alpha granule lumenGO:00310939.9CLU, SERPINA3
3extracellular spaceGO:00056158.1CLU, COL6A3, CSF1, SERPINA3
4extracellular exosomeGO:00700628.0CLU, COL6A3, CSF1, PGM1, SERPINA3

Biological processes related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoclast differentiationGO:004567210.2CSF1, CSF1R
2macrophage colony-stimulating factor signaling pathwayGO:003814510.2CSF1, CSF1R
3macrophage differentiationGO:003022510.2CSF1, CSF1R
4osteoclast differentiationGO:003031610.2CSF1, CSF1R
5hemopoiesisGO:00300979.9CSF1, CSF1R
6platelet degranulationGO:00025769.8CLU, SERPINA3
7acute-phase responseGO:00069539.6CD163, SERPINA3
8innate immune responseGO:00450879.4CLU, CSF1, CSF1R
9transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.4CSF1, CSF1R
10inflammatory responseGO:00069549.3CSF1, CSF1R, SERPINA3
11positive regulation of cell proliferationGO:00082849.2CLU, CSF1, CSF1R

Molecular functions related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00048679.3COL6A3, SERPINA3

Sources for Tenosynovial Giant Cell Tumor

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet