MCID: TNS001
MIFTS: 38

Tenosynovial Giant Cell Tumor malady

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Tenosynovial Giant Cell Tumor

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Aliases & Descriptions for Tenosynovial Giant Cell Tumor:

Name: Tenosynovial Giant Cell Tumor 10 12
Fibrous Histiocytoma of Tendon Sheath 10 65
 
Giant Cell Tumor of Tendon Sheath 10
Giant Cell Tumor of Tenosynovium 10

Classifications:



External Ids:

Disease Ontology10 DOID:314
ICD9CM29 727.02
NCIt42 C3402
UMLS65 C1318543

Summaries for Tenosynovial Giant Cell Tumor

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MalaCards based summary: Tenosynovial Giant Cell Tumor, also known as fibrous histiocytoma of tendon sheath, is related to synovitis and pigmented villonodular synovitis. An important gene associated with Tenosynovial Giant Cell Tumor is CSF1 (Colony Stimulating Factor 1), and among its related pathways are Macrophage Differentiation and Growth Inhibition by METS and Integrins in angiogenesis. Affiliated tissues include prostate, breast and myeloid.

Related Diseases for Tenosynovial Giant Cell Tumor

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Graphical network of the top 20 diseases related to Tenosynovial Giant Cell Tumor:



Diseases related to tenosynovial giant cell tumor

Symptoms for Tenosynovial Giant Cell Tumor

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Drugs & Therapeutics for Tenosynovial Giant Cell Tumor

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Drugs for Tenosynovial Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ImmunoglobulinsPhase 1, Phase 24477
2AntibodiesPhase 1, Phase 24477
3Grapefruit Seed ExtractNutraceuticalPhase 238
4
GemcitabineapprovedPhase 1188195058-81-460750
Synonyms:
103882-84-4
122111-03-9
2',2'-DiF-dC
2',2'-Difluoro-2'-deoxycytidine
2',2'-Difluorodeoxycytidine
2'-Deoxy-.beta.-D-2',2'-difluorocytidine
2'-Deoxy-2',2'-difluorocytidine
4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one
4-amino-1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
95058-81-4
AB1004842
AC1L1TUQ
C07650
CCRIS 8984
CHEBI:175901
CHEMBL888
CID60750
Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine
D02368
DB00441
DDFC
DFDC
DFdC
DFdCyd
Folfugem
GEO
Gamcitabine
GemLip
Gemcel
 
Gemcin
Gemcitabin
Gemcitabina
Gemcitabina [INN-Spanish]
Gemcitabine
Gemcitabine (USAN/INN)
Gemcitabine HCl
Gemcitabine Hydrochloride
Gemcitabine hydrochloride
Gemcitabine stereoisomer
Gemcitabinum
Gemcitabinum [INN-Latin]
Gemtro
Gemzar
Gemzar (hydrochloride)
HMS2089P10
HSDB 7567
Inno-D07001
LS-59139
LY 188011
LY-188011
LY188011
NCGC00168784-01
NChemBio.2007.10-comp25
NSC 613327
NSC613327
TL8005979
UNII-B76N6SBZ8R
ZINC18279854
Zefei
gemcitabine
nchembio.573-comp7
nchembio.90-comp2
5
PaclitaxelapprovedPhase 1262133069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
6Tubulin ModulatorsPhase 14279
7Antiviral AgentsPhase 18071
8Immunologic FactorsPhase 118483
9Immunosuppressive AgentsPhase 110422
10Antimitotic AgentsPhase 14296
11Albumin-Bound PaclitaxelPhase 12621
12Anti-Infective AgentsPhase 117220
13AntimetabolitesPhase 19454
14Antimetabolites, AntineoplasticPhase 15770
15Antineoplastic Agents, PhytogenicPhase 14294

Interventional clinical trials:

idNameStatusNCT IDPhase
1PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)RecruitingNCT02371369Phase 3
2Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)CompletedNCT01261429Phase 2
3Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell TumorRecruitingNCT02471716Phase 1, Phase 2
4MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)RecruitingNCT01643850Phase 2
5Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell TumorActive, not recruitingNCT01207492Phase 2
6A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell TumorRecruitingNCT02673736Phase 1
7Phase 1 Study of PLX7486 as Single Agent and With Gemcitabine Plus Nab-Paclitaxel in Patients With Advanced Solid TumorsRecruitingNCT01804530Phase 1
8A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Patients With Advanced Solid TumorsRecruitingNCT01494688Phase 1
9Safety Study of PLX108-01 in Patients With Solid TumorsActive, not recruitingNCT01004861Phase 1

Search NIH Clinical Center for Tenosynovial Giant Cell Tumor

Genetic Tests for Tenosynovial Giant Cell Tumor

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Anatomical Context for Tenosynovial Giant Cell Tumor

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MalaCards organs/tissues related to Tenosynovial Giant Cell Tumor:

33
Prostate, Breast, Myeloid, Cervix, T cells, Nk cells, Liver

Animal Models for Tenosynovial Giant Cell Tumor or affiliated genes

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Publications for Tenosynovial Giant Cell Tumor

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Articles related to Tenosynovial Giant Cell Tumor:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Intramuscular Tenosynovial Giant Cell Tumor, Diffuse-Type. (26755356)
2016
2
Diffuse Type Tenosynovial Giant Cell Tumor of the Ankle. (26996490)
2016
3
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. (26820289)
2016
4
Tenosynovial Giant Cell Tumor in the Dermis of the External Auditory Meatus. (27072732)
2016
5
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. (26337311)
2015
6
Malignant tenosynovial giant cell tumor of the leg: a radiologic-pathologic correlation and review of the literature. (25861547)
2015
7
Tenosynovial giant cell tumor arising from the posterior cruciate ligament: a case report and literature review. (26261570)
2015
8
Tenosynovial Giant Cell Tumor of Diffuse Type Mimicking Bony Metastasis Detected on F-18 FDG PET/CT. (25177381)
2014
9
Diffuse-type tenosynovial giant cell tumor with t(1;17)(p13;p13) and trisomy 5. (25189912)
2014
10
Intramuscular diffuse-type tenosynovial giant cell tumor of the deltoid muscle in a child. (24676801)
2014
11
Novel CSF1-S100A10 fusion gene and CSF1 transcript identified by RNA sequencing in tenosynovial giant cell tumors. (24604026)
2014
12
Partial response of a rare malignant metastatic diffuse tenosynovial giant cell tumor with benign histologic features, treated with SCH 717-454, an insulin growth factor receptor inhibitor, in combination with everolimus, an MTOR inhibitor. (23430345)
2013
13
Tenosynovial giant cell tumor in an unusual localization. (23619549)
2013
14
Tenosynovial giant cell tumor arising on the scapular region. (24403889)
2013
15
Chondroid tenosynovial giant cell tumor of the temporal bone. (23303171)
2013
16
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. (22784912)
2012
17
Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery. (22281719)
2012
18
Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. (21823110)
2012
19
Tenosynovial giant cell tumor in the cervico-thoracic junction. (23208911)
2012
20
Bilateral tenosynovial giant cell tumor of the knee accompanied by chronic ACL tear. (21590297)
2012
21
Tenosynovial giant cell tumor: case report and review. (22849738)
2012
22
Malignant diffuse-type tenosynovial giant cell tumor of the buttock. (22827766)
2012
23
Tenosynovial giant cell tumor of the thigh: positron emission tomography findings. (21869945)
2011
24
Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. (21577109)
2011
25
Localized tenosynovial giant cell tumor in both knee joints. (20354849)
2010
26
Therapeutic Antibodies Targeting CSF1 Impede Macrophage Recruitment in a Xenograft Model of Tenosynovial Giant Cell Tumor. (20981142)
2010
27
Clusterin is expressed in normal synoviocytes and in tenosynovial giant cell tumors of localized and diffuse types: diagnostic and histogenetic implications. (19542874)
2009
28
Yellow nodule on the distal finger. Xanthomatous localized tenosynovial giant cell tumor (TGCT) of the finger. (19687429)
2009
29
Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT). (18296418)
2008
30
Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors. (17918257)
2008
31
Tenosynovial giant cell tumor of the posterior arch of C1. (18309482)
2008
32
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
33
Tenosynovial giant cell tumor and pigmented villonodular synovitis. (17579851)
2007
34
Translocation and expression of CSF1 in pigmented villonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides. (17527089)
2007
35
Atypical tenosynovial giant cell tumor of the extensor hallucis longus tendon. (16868332)
2006
36
Diffuse-type tenosynovial giant cell tumor in association with neurofibromatosis type 1-Noonan syndrome: possibly more than a chance relationship. (16723851)
2006
37
A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. (16407111)
2006
38
Conditions suggesting lymphoma: case 3. Primary synovial lymphoma with osteoclast-like giant cells presenting as a tenosynovial giant-cell tumor. (15923579)
2005
39
A large, multiply recurrent tenosynovial giant cell tumor of the hand treated with resection and radiation therapy. (15074461)
2004
40
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
41
Localized tenosynovial giant cell tumor of tendon sheath. A case report. (10834013)
2000
42
Tenosynovial giant cell tumor of finger, localized type: a case report. (10642950)
1999
43
Analysis of 35 cases of localized and diffuse tenosynovial giant cell tumor: a report from the Chromosomes and Morphology (CHAMP) study group. (10392632)
1999
44
Diffuse variant tenosynovial giant cell tumor of the temporomandibular joint: report of a case. (9710197)
1998
45
Tenosynovial giant cell tumors: evidence for a desmin-positive dendritic cell subpopulation. (9796719)
1998
46
Tenosynovial giant-cell tumor in the knee joint. (7794435)
1995
47
Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis). (8033128)
1994
48
Scintigraphic evaluation of tenosynovial giant-cell tumor using technetium-99m(V)-dimercaptosuccinic acid. (8410292)
1993
49
Tenosynovial giant-cell tumor of the cervical spine. Case report. (1331365)
1992
50
Diffuse and localized tenosynovial giant cell tumor and pigmented villonodular synovitis: a clinicopathologic and flow cytometric DNA analysis. (1319390)
1992

Variations for Tenosynovial Giant Cell Tumor

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Expression for genes affiliated with Tenosynovial Giant Cell Tumor

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Search GEO for disease gene expression data for Tenosynovial Giant Cell Tumor.

Pathways for genes affiliated with Tenosynovial Giant Cell Tumor

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GO Terms for genes affiliated with Tenosynovial Giant Cell Tumor

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Biological processes related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1macrophage colony-stimulating factor signaling pathwayGO:003814510.0CSF1, CSF1R
2macrophage differentiationGO:00302259.9CSF1, CSF1R
3osteoclast differentiationGO:00303169.8CSF1, CSF1R
4positive regulation of osteoclast differentiationGO:00456729.7CSF1, CSF1R
5phosphatidylinositol metabolic processGO:00464889.5CSF1R, PDGFRB
6phosphatidylinositol-mediated signalingGO:00480159.3CSF1R, PDGFRB

Sources for Tenosynovial Giant Cell Tumor

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet