MCID: TRT001
MIFTS: 41

Teratocarcinoma malady

Category: Cancer diseases

Aliases & Classifications for Teratocarcinoma

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Aliases & Descriptions for Teratocarcinoma:

Name: Teratocarcinoma 10 47 12 36 65
 
Mixed Embryonal Carcinoma and Teratoma 10

Classifications:



External Ids:

Disease Ontology10 DOID:3305
MeSH36 D018243
SNOMED-CT59 67830002
NCIt42 C3756
UMLS65 C0206664

Summaries for Teratocarcinoma

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Disease Ontology:10 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.

MalaCards based summary: Teratocarcinoma, also known as mixed embryonal carcinoma and teratoma, is related to childhood teratocarcinoma of the testis and neuronitis. An important gene associated with Teratocarcinoma is TDGF1 (Teratocarcinoma-Derived Growth Factor 1), and among its related pathways are TGF-beta Signaling Pathway (sino) and Glypican 1 network. Affiliated tissues include testis, testis germ and ovary, and related mouse phenotypes are hearing/vestibular/ear and embryo.

Wikipedia:68 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

Related Diseases for Teratocarcinoma

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Graphical network of the top 20 diseases related to Teratocarcinoma:



Diseases related to teratocarcinoma

Symptoms for Teratocarcinoma

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Drugs & Therapeutics for Teratocarcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Teratocarcinoma


Cochrane evidence based reviews: teratocarcinoma

Genetic Tests for Teratocarcinoma

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Anatomical Context for Teratocarcinoma

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MalaCards organs/tissues related to Teratocarcinoma:

33
Testis, Testis germ, Ovary, Lung, Heart, Prostate, Breast

Animal Models for Teratocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Teratocarcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.8BMP2, CRABP1, FGF2, RARA, RARB, RARG
2MP:00053808.3BMP2, ENPP2, JUN, LAMB1, NANOG, RARA
3MP:00028737.8BMP2, CRABP1, ENPP2, JUN, RARA, RARB

Publications for Teratocarcinoma

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Articles related to Teratocarcinoma:

(show top 50)    (show all 510)
idTitleAuthorsYear
1
Differential expression of HERV-K (HML-2) proviruses in cells and virions of the teratocarcinoma cell line Tera-1. (25746218)
2015
2
Development of experimental tumors formed by mouse and human embryonic stem and teratocarcinoma cells after subcutaneous and intraperitoneal transplantations into immunodeficient and immunocompetent mice. (23051679)
2013
3
Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea. (22100652)
2011
4
Identification and partial characterization of soluble and membrane-bound KDN(deaminoneuraminic acid)-glycoproteins in human ovarian teratocarcinoma PA-1, and enhanced expression of free and bound KDN in cells cultured in mannose-rich media. (16897181)
2006
5
The detection of differentiation-inducing chemicals by using green fluorescent protein expression in genetically engineered teratocarcinoma cells. (16180984)
2005
6
Expression in murine teratocarcinoma F9 cells of transcription factors involved in pancreas development. (15194401)
2004
7
Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. (14990856)
2004
8
Identification and characterization of retinoic acid receptor beta2 target genes in F9 teratocarcinoma cells. (12805409)
2003
9
Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. (12810068)
2003
10
Expression of Sec61 alpha in F9 and P19 teratocarcinoma cells after retinoic acid treatment. (14509846)
2003
11
Apoptosis of the teratocarcinoma cell line Tera-1 leads to the cleavage of HERV-K10gag proteins by caspases and/or granzyme B. (12193232)
2002
12
Retinoic acid treatment enhances the acetylcholine contents in the human teratocarcinoma cell line NTera-2. (11102653)
2000
13
Proadrenomedullin NH(2)-terminal 20 peptide (PAMP) and adrenomedullin bind to teratocarcinoma cells. (10704725)
2000
14
Differential response to exogenous and endogenous activin in a human ovarian teratocarcinoma-derived cell line (PA-1): regulation by cell surface follistatin. (10342830)
1999
15
Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat. (10588714)
1999
16
Human growth-differentiation factor 3 (hGDF3): developmental regulation in human teratocarcinoma cell lines and expression in primary testicular germ cell tumours. (9467948)
1998
17
Expression of teratocarcinoma-derived growth factor-1 (TDGF-1) in testis germ cell tumors and its effects on growth and differentiation of embryonal carcinoma cell line NTERA2/D1. (9285688)
1997
18
Regulation of the laminin beta 1 (LAMB1), retinoic acid receptor beta, and bone morphogenetic protein 2 genes in mutant F9 teratocarcinoma cell lines partially deficient in cyclic AMP-dependent protein kinase activity. (9419418)
1997
19
Testicular microlithiasis associated with teratocarcinoma and intratubular germ cell neoplasia: a case report. (9354962)
1997
20
Dependence of mutation induction on fast-neutron energy in a human epithelial teratocarcinoma cell line (P3). (8927701)
1996
21
A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation. (8673928)
1996
22
Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP). (7850777)
1995
23
A teratocarcinoma-derived neurotrophic activity. (7662906)
1995
24
Ultraviolet irradiation, although it activates the transcription factor AP-1 in F9 teratocarcinoma stem cells, does not induce the full complement of differentiation-associated genes. (7521841)
1994
25
Developmentally regulated expression of two novel platelet-derived growth factor alpha-receptor transcripts in human teratocarcinoma cells. (8261442)
1994
26
Kinetics of in vitro mineralization by an osteogenic clonal cell line (C1) derived from mouse teratocarcinoma. (8405769)
1993
27
Changes in Hox1.6, c-jun, and Oct-3 gene expressions are associated with teratocarcinoma F9 cell differentiation in three different ways of induction. (8453995)
1993
28
Characterization of a DNA-damage-recognition protein from F9 teratocarcinoma cells, which is inducible by retinoic acid and cyclic AMP. (8382473)
1993
29
Retinoic acid modulation of transmembrane signaling. Analysis in F9 teratocarcinoma cells. (2170395)
1990
30
Alterations of cellular characteristics of a human ovarian teratocarcinoma cell line after in vitro treatment with retinoids. (2373285)
1990
31
Milk plasma supports growth and differentiation of a mouse teratocarcinoma cell line. (2732192)
1989
32
Actin cytoskeleton of extraembryonic endoderm and teratocarcinoma-derived endoderm cells. (2553454)
1989
33
Basement membrane matrices in mouse embryogenesis, teratocarcinoma differentiation and in neuromuscular maturation. (2485704)
1989
34
Repression of the IgH enhancer in teratocarcinoma cells associated with a novel octamer factor. (2536195)
1989
35
Plasminogen activator expression in F9 teratocarcinoma embryoid bodies and their endoderm derivatives. (2516796)
1989
36
Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells. (2470007)
1989
37
An early effect of retinoic acid: cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation. (3422432)
1988
38
Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells. (3342876)
1988
39
Isolation of complementary DNA clones for genes exhibiting reduced expression after treatment of mouse teratocarcinoma stem cells with a tumor-promoting phorbol ester. (2821315)
1987
40
Interferon inducibility and sensitivity of human teratocarcinoma-derived cell lines. (2440957)
1987
41
Induction of class I major histocompatibility complex antigens in human teratocarcinoma cells by interferon without induction of differentiation, growth inhibition, or resistance to viral infection. (3026615)
1987
42
Decreased c-myc expression is an early event in retinoic acid-induced differentiation of F9 teratocarcinoma cells. (3526333)
1986
43
Differentiation alters the unstable expression of adenine phosphoribosyltransferase in mouse teratocarcinoma cells. (3783283)
1986
44
Inhibition of gap junctional intercellular communication in human teratocarcinoma cells by organochlorine pesticides. (3952740)
1986
45
Isolation and characterization of the cDNAs corresponding to mRNAs abundant in undifferentiated mouse embryonal teratocarcinoma stem cells, but not in differentiated mouse parietal endoderm cells. (2434467)
1986
46
The outgrowth of parietal endoderm from mouse teratocarcinoma stem-cell embryoid bodies. (2430849)
1986
47
Characterization of three mouse monoclonal antibodies that react with high-molecular-mass glycopeptides isolated from F9 mouse teratocarcinoma cells. (2429884)
1986
48
Multipotent mutator strain of mouse teratocarcinoma cells. (3859019)
1985
49
Expression of N-myc in teratocarcinoma stem cells and mouse embryos. (3840574)
1985
50
Molecular biology of embryonic and teratocarcinoma stem cells. Proceedings of an international symposium. Prague, Czechoslovakia, 10-15 September 1984. (6535648)
1984

Variations for Teratocarcinoma

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Expression for genes affiliated with Teratocarcinoma

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Search GEO for disease gene expression data for Teratocarcinoma.

Pathways for genes affiliated with Teratocarcinoma

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GO Terms for genes affiliated with Teratocarcinoma

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Biological processes related to Teratocarcinoma according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1retinal pigment epithelium developmentGO:000340610.7RARB, RARG
2embryonic eye morphogenesisGO:004804810.6RARB, RARG
3cell migration involved in sprouting angiogenesisGO:000204210.6FGF2, TDGF1
4positive regulation of programmed cell deathGO:004306810.5RARB, RARG
5negative regulation of chondrocyte differentiationGO:003233110.5RARB, RARG
6trachea cartilage developmentGO:006053410.5RARA, RARG
7face developmentGO:006032410.5RARA, RARG
8corticotropin hormone secreting cell differentiationGO:006012810.5BMP2, FGF2
9chondroblast differentiationGO:006059110.5FGF2, RARA
10embryonic hindlimb morphogenesisGO:003511610.4RARB, RARG
11ventricular cardiac muscle cell differentiationGO:005501210.4RARA, RARB
12glandular epithelial cell developmentGO:000206810.3RARA, RARB, RARG
13outflow tract septum morphogenesisGO:000314810.3RARA, RARB
14negative regulation of cartilage developmentGO:006103710.3RARA, RARB, RARG
15steroid hormone mediated signaling pathwayGO:004340110.2RARA, RARB
16growth plate cartilage developmentGO:000341710.1RARB, RARG
17regulation of myelinationGO:003164110.1RARA, RARB, RARG
18bone developmentGO:006034810.0RARA, RARB, RARG
19activation of MAPK activityGO:000018710.0BMP2, FGF2, TDGF1
20multicellular organism growthGO:00352649.9RARA, RARB, RARG
21retinoic acid receptor signaling pathwayGO:00483849.7RARA, RARB, RARG
22negative regulation of apoptotic processGO:00430669.4JUN, RARA, RARB, RARG

Molecular functions related to Teratocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1retinoic acid bindingGO:00019729.8CRABP1, RARA

Sources for Teratocarcinoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet