MCID: TRT001
MIFTS: 36

Teratocarcinoma malady

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Teratocarcinoma

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Aliases & Descriptions for Teratocarcinoma:

Name: Teratocarcinoma 11 49 38 13 67
 
Mixed Embryonal Carcinoma and Teratoma 11

Classifications:



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Disease Ontology11 DOID:3305
MeSH38 D018243
SNOMED-CT61 67830002
NCIt44 C3756

Summaries for Teratocarcinoma

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Disease Ontology:11 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.

MalaCards based summary: Teratocarcinoma, also known as mixed embryonal carcinoma and teratoma, is related to teratoma and childhood teratocarcinoma of the testis. An important gene associated with Teratocarcinoma is TDGF1 (Teratocarcinoma-Derived Growth Factor 1), and among its related pathways are Human Early Embryo Development and Vitamin A and carotenoid metabolism. Affiliated tissues include testis, lung and bone, and related mouse phenotypes are embryo and normal.

Related Diseases for Teratocarcinoma

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Graphical network of the top 20 diseases related to Teratocarcinoma:



Diseases related to teratocarcinoma

Symptoms for Teratocarcinoma

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Drugs & Therapeutics for Teratocarcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Teratocarcinoma


Cochrane evidence based reviews: teratocarcinoma

Genetic Tests for Teratocarcinoma

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Anatomical Context for Teratocarcinoma

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MalaCards organs/tissues related to Teratocarcinoma:

35
Testis, Lung, Bone, Colon, Brain, Pineal, Cardiac myocytes

Animal Models for Teratocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Teratocarcinoma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.0ENPP2, JUN, LAMB1, NANOG, NR6A1, POU5F1
2MP:00028738.2CRABP1, ENPP2, FGF4, JUN, POU5F1, RARA

Publications for Teratocarcinoma

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Articles related to Teratocarcinoma:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/I^-catenin signaling. (25138740)
2014
2
Wnt/I^-catenin signaling pathway upregulates c-Myc expression to promote cell proliferation of P19 teratocarcinoma cells. (22976998)
2012
3
Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells. (18164278)
2008
4
Testicular teratocarcinoma associated with testicular microlithiasis. (17464445)
2008
5
Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. (17716626)
2007
6
Identification and partial characterization of soluble and membrane-bound KDN(deaminoneuraminic acid)-glycoproteins in human ovarian teratocarcinoma PA-1, and enhanced expression of free and bound KDN in cells cultured in mannose-rich media. (16897181)
2006
7
The detection of differentiation-inducing chemicals by using green fluorescent protein expression in genetically engineered teratocarcinoma cells. (16180984)
2005
8
A role for p21 (WAF1) in the cAMP-dependent differentiation of F9 teratocarcinoma cells into parietal endoderm. (15707594)
2005
9
Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. (14990856)
2004
10
Stem cell based therapeutical approach of male infertility by teratocarcinoma derived germ cells. (15163638)
2004
11
Identification and characterization of retinoic acid receptor beta2 target genes in F9 teratocarcinoma cells. (12805409)
2003
12
Transient modulation of cytoplasmic and nuclear retinoid receptors expression in differentiating human teratocarcinoma NT2 cells. (12485405)
2003
13
Apoptosis of the teratocarcinoma cell line Tera-1 leads to the cleavage of HERV-K10gag proteins by caspases and/or granzyme B. (12193232)
2002
14
Induction of instability of p34(cdc2) expression by treatment with cisplatin (CDDP) in mouse teratocarcinoma F9 cells. (11790456)
2002
15
Cytotoxic targeting of F9 teratocarcinoma tumours with anti-ED-B fibronectin scFv antibody modified liposomes. (12085265)
2002
16
Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat. (10588714)
1999
17
Expression of teratocarcinoma-derived growth factor-1 (TDGF-1) in testis germ cell tumors and its effects on growth and differentiation of embryonal carcinoma cell line NTERA2/D1. (9285688)
1997
18
Testicular microlithiasis associated with teratocarcinoma and intratubular germ cell neoplasia: a case report. (9354962)
1997
19
Dependence of mutation induction on fast-neutron energy in a human epithelial teratocarcinoma cell line (P3). (8927701)
1996
20
Hinokitiol induces differentiation of teratocarcinoma F9 cells. (8593483)
1995
21
Saporin toxins directed to basic fibroblast growth factor receptors effectively target human ovarian teratocarcinoma in an animal model. (8630880)
1995
22
Ultraviolet irradiation, although it activates the transcription factor AP-1 in F9 teratocarcinoma stem cells, does not induce the full complement of differentiation-associated genes. (7521841)
1994
23
Characterization of conventional protein kinase C (PKC) isotype expression during F9 teratocarcinoma differentiation. Overexpression of PKC alpha alters the expression of some differentiation-dependent genes. (7961696)
1994
24
Globo-series carbohydrate antigens are expressed in different forms on human and murine teratocarcinoma-derived cells. (7960243)
1994
25
Gene therapy of murine teratocarcinoma: separate functions for insulin-like growth factors I and II in immunogenicity and differentiation. (8016120)
1994
26
Kinetics of in vitro mineralization by an osteogenic clonal cell line (C1) derived from mouse teratocarcinoma. (8405769)
1993
27
Changes in Hox1.6, c-jun, and Oct-3 gene expressions are associated with teratocarcinoma F9 cell differentiation in three different ways of induction. (8453995)
1993
28
Characterization of a DNA-damage-recognition protein from F9 teratocarcinoma cells, which is inducible by retinoic acid and cyclic AMP. (8382473)
1993
29
Homeobox-containing genes in teratocarcinoma embryoid bodies: a possible role for Hox-D12 (Hox-4.7) in establishing the extraembryonic endoderm lineage in the mouse. (8103490)
1993
30
Testicular teratocarcinoma with intracaval metastases to the heart. (1413360)
1992
31
The expression and localization of urokinase-type plasminogen activator and its type 1 inhibitor are regulated by retinoic acid and fibroblast growth factor in human teratocarcinoma cells. (1905574)
1991
32
Retinoic acid modulation of transmembrane signaling. Analysis in F9 teratocarcinoma cells. (2170395)
1990
33
Alterations of cellular characteristics of a human ovarian teratocarcinoma cell line after in vitro treatment with retinoids. (2373285)
1990
34
Actin cytoskeleton of extraembryonic endoderm and teratocarcinoma-derived endoderm cells. (2553454)
1989
35
Plasminogen activator expression in F9 teratocarcinoma embryoid bodies and their endoderm derivatives. (2516796)
1989
36
Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. (2792079)
1989
37
An early effect of retinoic acid: cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation. (3422432)
1988
38
A teratocarcinoma glycoprotein carrying a developmentally regulated carbohydrate marker is a member of the immunoglobulin gene superfamily. (2963822)
1988
39
MHC class I expression by developmental tumors: teratocarcinoma stem cells are TCA positive. (3170287)
1988
40
Induction of class I major histocompatibility complex antigens in human teratocarcinoma cells by interferon without induction of differentiation, growth inhibition, or resistance to viral infection. (3026615)
1987
41
The effect of dibutyryl cyclic AMP and butyrate on F9 teratocarcinoma cellular retinoic acid-binding protein activity. (3031026)
1987
42
Metastatic enhancement and growth inhibition by glucocorticoid and its receptors in mouse teratocarcinoma OTT6050 in vivo. (3660400)
1987
43
Expression of c-myc during differentiation of the human teratocarcinoma cell line Tera-2. (3327864)
1987
44
Decreased c-myc expression is an early event in retinoic acid-induced differentiation of F9 teratocarcinoma cells. (3526333)
1986
45
Differentiation alters the unstable expression of adenine phosphoribosyltransferase in mouse teratocarcinoma cells. (3783283)
1986
46
The outgrowth of parietal endoderm from mouse teratocarcinoma stem-cell embryoid bodies. (2430849)
1986
47
Expression of N-myc in teratocarcinoma stem cells and mouse embryos. (3840574)
1985
48
Roles of extracellular matrix components in differentiating teratocarcinoma cells. (4044595)
1985
49
Clonal growth and mesenchymal differentiation of PCC3/A/1 teratocarcinoma cells in serum-free medium. (3995602)
1985
50
Pleiotropic phenotypic expression in cybrids derived from mouse teratocarcinoma cells fused with rat myoblast cytoplasts. (2416471)
1985

Variations for Teratocarcinoma

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Expression for genes affiliated with Teratocarcinoma

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Search GEO for disease gene expression data for Teratocarcinoma.

Pathways for genes affiliated with Teratocarcinoma

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GO Terms for genes affiliated with Teratocarcinoma

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Biological processes related to Teratocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1endodermal cell fate specificationGO:000171410.7NANOG, POU5F1
2glandular epithelial cell developmentGO:000206810.7RARA, RARB
3ventricular cardiac muscle cell differentiationGO:005501210.7RARA, RARB
4negative regulation of cartilage developmentGO:006103710.6RARA, RARB
5outflow tract septum morphogenesisGO:000314810.6RARA, RARB
6growth plate cartilage developmentGO:000341710.5RARA, RARB
7retinoic acid receptor signaling pathwayGO:004838410.5RARA, RARB
8chondroblast differentiationGO:006059110.4FGF4, RARA
9regulation of myelinationGO:003164110.3RARA, RARB
10somatic stem cell population maintenanceGO:003501910.0NANOG, POU5F1, TDGF1
11cellular processGO:00099879.9JUN, RRAS2
12negative regulation of apoptotic processGO:00430669.4FGF4, JUN, RARA, RARB, TDGF1
13positive regulation of cell proliferationGO:00082849.0FGF4, JUN, RARA, RARB, TDGF1
14positive regulation of transcription from RNA polymerase II promoterGO:00459448.7FGF4, JUN, NANOG, NR6A1, POU5F1, RARA

Molecular functions related to Teratocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1retinoic acid receptor activityGO:000370810.6RARA, RARB
2retinoic acid bindingGO:000197210.3CRABP1, RARA
3steroid hormone receptor activityGO:000370710.3NR6A1, RARA, RARB
4sequence-specific DNA bindingGO:00435659.0JUN, NANOG, NR6A1, POU5F1, RARA, RARB

Sources for Teratocarcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet