MCID: TRT001
MIFTS: 41

Teratocarcinoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Teratocarcinoma

MalaCards integrated aliases for Teratocarcinoma:

Name: Teratocarcinoma 12 51 41 14 69
Mixed Embryonal Carcinoma and Teratoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3305
MeSH 41 D018243
NCIt 46 C3756
SNOMED-CT 64 67830002
UMLS 69 C0206664

Summaries for Teratocarcinoma

Disease Ontology : 12 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.

MalaCards based summary : Teratocarcinoma, also known as mixed embryonal carcinoma and teratoma, is related to embryonal carcinoma and childhood teratocarcinoma of the testis. An important gene associated with Teratocarcinoma is TDGF1 (Teratocarcinoma-Derived Growth Factor 1), and among its related pathways/superpathways are Developmental Biology and Pathways in cancer. Affiliated tissues include testis, testis germ and ovary, and related phenotypes are embryo and mortality/aging

Wikipedia : 72 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

Related Diseases for Teratocarcinoma

Diseases related to Teratocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 embryonal carcinoma 27.6 CRABP1 FGF4 JUN NR6A1 POU5F1 RARA
2 childhood teratocarcinoma of the testis 12.0
3 neuronitis 10.3
4 multiple mitochondrial dysfunctions syndrome 5 10.0
5 mediastinitis 10.0
6 ovarian embryonal carcinoma 9.9 NANOG POU5F1
7 insulin-like growth factor i 9.9
8 leukemia 9.9
9 teratoma 9.9
10 germ cells tumors 9.9
11 mixed germ cell cancer 9.9 CRABP1 POU5F1 TDGF1
12 neuroblastoma 9.8
13 testicular microlithiasis 9.8
14 mature teratoma 9.8
15 embryonal testis carcinoma 9.8
16 cytomegalovirus infection 9.8
17 venous hemangioma 9.8 NANOG POU5F1
18 alzheimer disease 9.7
19 blood group, i system 9.7
20 hairy nose tip 9.7
21 systemic lupus erythematosus 9.7
22 ovarian cancer 9.7
23 polykaryocytosis inducer 9.7
24 spermatogenic failure, x-linked, 1 9.7
25 combined immunodeficiency, x-linked 9.7
26 ovarian germ cell cancer 9.7
27 mycobacterium tuberculosis 1 9.7
28 takenouchi-kosaki syndrome 9.7
29 anal fistula 9.7
30 male infertility 9.7
31 severe combined immunodeficiency 9.7
32 meningocele 9.7
33 heart disease 9.7
34 allergic hypersensitivity disease 9.7
35 cervicitis 9.7
36 adenocarcinoma 9.7
37 cerebritis 9.7
38 seminoma 9.7
39 infertility 9.7
40 adenoma 9.7
41 hyperthyroidism 9.7
42 herpes simplex 9.7
43 duodenitis 9.7
44 lupus erythematosus 9.7
45 aldosterone-producing adenoma 9.7
46 acute promyelocytic leukemia 9.5 CRABP1 JUN RARA RARB

Graphical network of the top 20 diseases related to Teratocarcinoma:



Diseases related to Teratocarcinoma

Symptoms & Phenotypes for Teratocarcinoma

MGI Mouse Phenotypes related to Teratocarcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.96 JUN LAMB1 NANOG NR6A1 POU5F1 RARA
2 mortality/aging MP:0010768 9.73 TDGF1 CRABP1 ENPP2 FGF4 JUN LAMB1
3 limbs/digits/tail MP:0005371 9.63 CRABP1 FGF4 LAMB1 NR6A1 RARA RARB
4 normal MP:0002873 9.32 CRABP1 ENPP2 FGF4 GSR JUN POU5F1

Drugs & Therapeutics for Teratocarcinoma

Search Clinical Trials , NIH Clinical Center for Teratocarcinoma

Cochrane evidence based reviews: teratocarcinoma

Genetic Tests for Teratocarcinoma

Anatomical Context for Teratocarcinoma

MalaCards organs/tissues related to Teratocarcinoma:

38
Testis, Testis Germ, Ovary, Bone, Lung, Brain, Colon

Publications for Teratocarcinoma

Articles related to Teratocarcinoma:

(show top 50) (show all 517)
# Title Authors Year
1
New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells. ( 29439916 )
2018
2
Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells. ( 29207191 )
2018
3
Correlative Studies Unravelling the Possible Mechanism of Cell Death in Tideglusib-Treated Human Ovarian Teratocarcinoma-Derived PA-1 Cells. ( 29431064 )
2017
4
Frizzled gene expression and negative regulation of canonical WNT-I^-catenin signaling in mouse F9 teratocarcinoma cells. ( 28177772 )
2017
5
Tumorigenic and Differentiation Potentials of Embryonic Stem Cells Depend on TGFI^ Family Signaling: Lessons from Teratocarcinoma Cells Stimulated to Differentiate with Retinoic Acid. ( 28798778 )
2017
6
Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy. ( 29066898 )
2017
7
Lysine methylation represses p53 activity in teratocarcinoma cancer cells. ( 27535933 )
2016
8
Vitamin D3 stimulates embryonic stem cells but inhibits migration and growth of ovarian cancer and teratocarcinoma cell lines. ( 27091127 )
2016
9
Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin. ( 27116544 )
2016
10
Actions of activin A, connective tissue growth factor, hepatocyte growth factor and teratocarcinoma-derived growth factor 1 on the development of the bovine preimplantation embryo. ( 27185102 )
2016
11
Differential expression of HERV-K (HML-2) proviruses in cells and virions of the teratocarcinoma cell line Tera-1. ( 25746218 )
2015
12
Pleuritis caused by Acremonium strictum in a patient with metastatic testicular teratocarcinoma. ( 26042869 )
2015
13
The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1. ( 25761220 )
2015
14
Nicotinamide induces apoptosis of F9 mouse teratocarcinoma stem cells by downregulation of SATB1 expression. ( 25596087 )
2015
15
Ligand-independent androgen receptors promote ovarian teratocarcinoma cell growth by stimulating self-renewal of cancer stem/progenitor cells. ( 24793306 )
2014
16
Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/I^-catenin signaling. ( 25138740 )
2014
17
MicroRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonic carcinoma P19 cells. ( 23007514 )
2013
18
Teratocarcinoma in a non seminomatous, mixed germ cell tumour of the testis-a rare entity. ( 23998086 )
2013
19
Extracellular syntaxin4 triggers the differentiation program in teratocarcinoma F9 cells that impacts cell adhesion properties. ( 23884628 )
2013
20
Murine teratocarcinoma-derived neuronal cultures. ( 23975819 )
2013
21
KSRP silencing favors neural differentiation of P19 teratocarcinoma cells. ( 23462617 )
2013
22
Development of experimental tumors formed by mouse and human embryonic stem and teratocarcinoma cells after subcutaneous and intraperitoneal transplantations into immunodeficient and immunocompetent mice. ( 23051679 )
2013
23
MicroRNA-21 promotes the ovarian teratocarcinoma PA1 cell line by sustaining cancer stem/progenitor populations in vitro. ( 23890123 )
2013
24
Wnt/I^-catenin signaling pathway upregulates c-Myc expression to promote cell proliferation of P19 teratocarcinoma cells. ( 22976998 )
2012
25
Teratocarcinoma formation in embryonic stem cell-derived neural progenitor hippocampal transplants. ( 22776287 )
2012
26
Presacral teratocarcinoma presenting as anal fistula and rectal adenocarcinoma: a unique case presentation and literature review. ( 22611366 )
2012
27
Primary CNS teratocarcinoma. ( 22363315 )
2012
28
Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell. ( 19943082 )
2011
29
Unusual autopsy finding in a case of metastatic teratocarcinoma. ( 21109467 )
2011
30
A spontaneous teratocarcinoma in the testis of a swiss albino mouse. ( 21270422 )
2011
31
Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea. ( 22100652 )
2011
32
Teratocarcinoma-derived growth factor 1 (TDGF1) sequence variants in patients with congenital heart defect. ( 19853938 )
2011
33
Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro. ( 20385969 )
2010
34
A teratocarcinoma-like human embryonic stem cell (hESC) line and four hESC lines reveal potentially oncogenic genomic changes. ( 20428235 )
2010
35
Effects of insulin-like growth factor binding protein 7 on apoptosis in human teratocarcinoma cells in vitro. ( 20393014 )
2010
36
Angiogenesis and vascular network of teratocarcinoma from embryonic stem cell transplant into seminiferous tubules. ( 19513074 )
2009
37
Suppression of teratocarcinoma growth by soluble TRAIL gene expression driven by the progression-elevated gene-3 promoter. ( 19823015 )
2009
38
Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke. ( 18514379 )
2008
39
Moesin signalling induces F9 teratocarcinoma cells to differentiate into primitive extraembryonic endoderm. ( 17993262 )
2008
40
Testicular teratocarcinoma associated with testicular microlithiasis. ( 17464445 )
2008
41
Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells. ( 18237746 )
2008
42
Mediastinal teratocarcinoma as initial manifestation of asymptomatic HIV infection: a case report. ( 18663349 )
2008
43
Primary mediastinal giant teratocarcinoma. ( 18626155 )
2008
44
Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells. ( 18164278 )
2008
45
Cervical mature teratoma 17 years after initial treatment of testicular teratocarcinoma: report of a late relapse. ( 17201931 )
2007
46
ER stress induces the expression of Jpk, which inhibits cell cycle progression in F9 teratocarcinoma cell. ( 17404020 )
2007
47
Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. ( 17716626 )
2007
48
Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements. ( 17875646 )
2007
49
22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. ( 17689017 )
2007
50
Noxp20 and Noxp70, two new markers of early neuronal differentiation, detected in teratocarcinoma-derived neuroectodermic precursor cells. ( 17029606 )
2006

Variations for Teratocarcinoma

Expression for Teratocarcinoma

Search GEO for disease gene expression data for Teratocarcinoma.

Pathways for Teratocarcinoma

GO Terms for Teratocarcinoma

Biological processes related to Teratocarcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 FGF4 JUN NANOG NR6A1 POU5F1 RARA
2 negative regulation of apoptotic process GO:0043066 9.89 FGF4 JUN RARA RARB TDGF1
3 positive regulation of cell proliferation GO:0008284 9.88 FGF4 JUN RARA RARB TDGF1
4 somatic stem cell population maintenance GO:0035019 9.61 NANOG POU5F1 TDGF1
5 steroid hormone mediated signaling pathway GO:0043401 9.58 NR6A1 RARA RARB
6 retinoic acid receptor signaling pathway GO:0048384 9.52 RARA RARB
7 regulation of myelination GO:0031641 9.51 RARA RARB
8 negative regulation of cartilage development GO:0061037 9.46 RARA RARB
9 growth plate cartilage development GO:0003417 9.32 RARA RARB
10 endodermal cell fate specification GO:0001714 9.26 NANOG POU5F1
11 chondroblast differentiation GO:0060591 9.16 FGF4 RARA
12 ventricular cardiac muscle cell differentiation GO:0055012 8.96 RARA RARB
13 glandular epithelial cell development GO:0002068 8.62 RARA RARB

Molecular functions related to Teratocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding transcription factor activity GO:0003700 9.73 JUN NANOG NR6A1 POU5F1 RARA RARB
2 steroid hormone receptor activity GO:0003707 9.33 NR6A1 RARA RARB
3 retinoic acid binding GO:0001972 9.32 CRABP1 RARA
4 sequence-specific DNA binding GO:0043565 9.1 JUN NANOG NR6A1 POU5F1 RARA RARB
5 retinoic acid receptor activity GO:0003708 8.96 RARA RARB

Sources for Teratocarcinoma

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7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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36 KEGG
37 LifeMap
39 MedGen
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42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
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65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
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70 UMLS via Orphanet
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