MCID: TRT001
MIFTS: 38

Teratocarcinoma malady

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Teratocarcinoma

Aliases & Descriptions for Teratocarcinoma:

Name: Teratocarcinoma 12 52 42 14 69
Mixed Embryonal Carcinoma and Teratoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3305
MeSH 42 D018243
NCIt 47 C3756
SNOMED-CT 64 67830002
UMLS 69 C0206664

Summaries for Teratocarcinoma

Disease Ontology : 12 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.

MalaCards based summary : Teratocarcinoma, also known as mixed embryonal carcinoma and teratoma, is related to childhood teratocarcinoma of the testis and neuronitis. An important gene associated with Teratocarcinoma is TDGF1 (Teratocarcinoma-Derived Growth Factor 1), and among its related pathways/superpathways are Developmental Biology and Pathways in cancer. Affiliated tissues include testis, ovary and testis germ, and related phenotypes are embryo and mortality/aging

Wikipedia : 71 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

Related Diseases for Teratocarcinoma

Graphical network of the top 20 diseases related to Teratocarcinoma:



Diseases related to Teratocarcinoma

Symptoms & Phenotypes for Teratocarcinoma

MGI Mouse Phenotypes related to Teratocarcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.85 ENPP2 FGF4 JUN LAMB1 NANOG NR6A1
2 mortality/aging MP:0010768 9.73 CRABP1 ENPP2 FGF4 JUN LAMB1 NANOG
3 normal MP:0002873 9.28 JUN POU5F1 RARA RARB SEPT3 TDGF1

Drugs & Therapeutics for Teratocarcinoma

Search Clinical Trials , NIH Clinical Center for Teratocarcinoma

Cochrane evidence based reviews: teratocarcinoma

Genetic Tests for Teratocarcinoma

Anatomical Context for Teratocarcinoma

MalaCards organs/tissues related to Teratocarcinoma:

39
Testis, Ovary, Testis Germ, Lung, Bone, Colon, Brain

Publications for Teratocarcinoma

Articles related to Teratocarcinoma:

(show top 50) (show all 511)
id Title Authors Year
1
Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin. ( 27116544 )
2016
2
Actions of activin A, connective tissue growth factor, hepatocyte growth factor and teratocarcinoma-derived growth factor 1 on the development of the bovine preimplantation embryo. ( 27185102 )
2016
3
Vitamin D3 stimulates embryonic stem cells but inhibits migration and growth of ovarian cancer and teratocarcinoma cell lines. ( 27091127 )
2016
4
Lysine methylation represses p53 activity in teratocarcinoma cancer cells. ( 27535933 )
2016
5
Differential expression of HERV-K (HML-2) proviruses in cells and virions of the teratocarcinoma cell line Tera-1. ( 25746218 )
2015
6
Nicotinamide induces apoptosis of F9 mouse teratocarcinoma stem cells by downregulation of SATB1 expression. ( 25596087 )
2015
7
Pleuritis caused by Acremonium strictum in a patient with metastatic testicular teratocarcinoma. ( 26042869 )
2015
8
The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1. ( 25761220 )
2015
9
Ligand-independent androgen receptors promote ovarian teratocarcinoma cell growth by stimulating self-renewal of cancer stem/progenitor cells. ( 24793306 )
2014
10
Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/I^-catenin signaling. ( 25138740 )
2014
11
Extracellular syntaxin4 triggers the differentiation program in teratocarcinoma F9 cells that impacts cell adhesion properties. ( 23884628 )
2013
12
Teratocarcinoma in a non seminomatous, mixed germ cell tumour of the testis-a rare entity. ( 23998086 )
2013
13
MicroRNA-21 promotes the ovarian teratocarcinoma PA1 cell line by sustaining cancer stem/progenitor populations in vitro. ( 23890123 )
2013
14
Development of experimental tumors formed by mouse and human embryonic stem and teratocarcinoma cells after subcutaneous and intraperitoneal transplantations into immunodeficient and immunocompetent mice. ( 23051679 )
2013
15
Murine teratocarcinoma-derived neuronal cultures. ( 23975819 )
2013
16
KSRP silencing favors neural differentiation of P19 teratocarcinoma cells. ( 23462617 )
2013
17
MicroRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonic carcinoma P19 cells. ( 23007514 )
2013
18
Wnt/I^-catenin signaling pathway upregulates c-Myc expression to promote cell proliferation of P19 teratocarcinoma cells. ( 22976998 )
2012
19
Presacral teratocarcinoma presenting as anal fistula and rectal adenocarcinoma: a unique case presentation and literature review. ( 22611366 )
2012
20
Teratocarcinoma formation in embryonic stem cell-derived neural progenitor hippocampal transplants. ( 22776287 )
2012
21
Primary CNS teratocarcinoma. ( 22363315 )
2012
22
Unusual autopsy finding in a case of metastatic teratocarcinoma. ( 21109467 )
2011
23
Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea. ( 22100652 )
2011
24
A spontaneous teratocarcinoma in the testis of a swiss albino mouse. ( 21270422 )
2011
25
Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell. ( 19943082 )
2011
26
Teratocarcinoma-derived growth factor 1 (TDGF1) sequence variants in patients with congenital heart defect. ( 19853938 )
2011
27
Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro. ( 20385969 )
2010
28
Effects of insulin-like growth factor binding protein 7 on apoptosis in human teratocarcinoma cells in vitro. ( 20393014 )
2010
29
A teratocarcinoma-like human embryonic stem cell (hESC) line and four hESC lines reveal potentially oncogenic genomic changes. ( 20428235 )
2010
30
Angiogenesis and vascular network of teratocarcinoma from embryonic stem cell transplant into seminiferous tubules. ( 19513074 )
2009
31
Suppression of teratocarcinoma growth by soluble TRAIL gene expression driven by the progression-elevated gene-3 promoter. ( 19823015 )
2009
32
Primary mediastinal giant teratocarcinoma. ( 18626155 )
2008
33
Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells. ( 18237746 )
2008
34
Mediastinal teratocarcinoma as initial manifestation of asymptomatic HIV infection: a case report. ( 18663349 )
2008
35
Moesin signalling induces F9 teratocarcinoma cells to differentiate into primitive extraembryonic endoderm. ( 17993262 )
2008
36
Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke. ( 18514379 )
2008
37
Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells. ( 18164278 )
2008
38
Testicular teratocarcinoma associated with testicular microlithiasis. ( 17464445 )
2008
39
22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. ( 17689017 )
2007
40
Cervical mature teratoma 17 years after initial treatment of testicular teratocarcinoma: report of a late relapse. ( 17201931 )
2007
41
ER stress induces the expression of Jpk, which inhibits cell cycle progression in F9 teratocarcinoma cell. ( 17404020 )
2007
42
Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. ( 17716626 )
2007
43
Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements. ( 17875646 )
2007
44
Noxp20 and Noxp70, two new markers of early neuronal differentiation, detected in teratocarcinoma-derived neuroectodermic precursor cells. ( 17029606 )
2006
45
Polyunsaturated fatty acids mobilize intracellular Ca2+ in NT2 human teratocarcinoma cells by causing release of Ca2+ from mitochondria. ( 16601147 )
2006
46
Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamma and retinoid-independent pathways. ( 16788091 )
2006
47
Identification and partial characterization of soluble and membrane-bound KDN(deaminoneuraminic acid)-glycoproteins in human ovarian teratocarcinoma PA-1, and enhanced expression of free and bound KDN in cells cultured in mannose-rich media. ( 16897181 )
2006
48
Cytotoxicity of a novel fibroblast growth factor receptor targeted immunotoxin on a human ovarian teratocarcinoma cell line. ( 16999598 )
2006
49
Galpha13 activation rescues moesin-depletion induced apoptosis in F9 teratocarcinoma cells. ( 16860319 )
2006
50
Jpk, a novel cell death inducer, regulates the expression of Hoxa7 in F9 teratocarcinoma cells, but not during apoptosis. ( 17384261 )
2006

Variations for Teratocarcinoma

Expression for Teratocarcinoma

Search GEO for disease gene expression data for Teratocarcinoma.

Pathways for Teratocarcinoma

GO Terms for Teratocarcinoma

Biological processes related to Teratocarcinoma according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.89 FGF4 JUN RARA RARB TDGF1
2 positive regulation of cell proliferation GO:0008284 9.88 FGF4 JUN RARA RARB TDGF1
3 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.87 FGF4 JUN NANOG NR6A1 POU5F1 RARA
4 somatic stem cell population maintenance GO:0035019 9.61 NANOG POU5F1 TDGF1
5 steroid hormone mediated signaling pathway GO:0043401 9.58 NR6A1 RARA RARB
6 outflow tract septum morphogenesis GO:0003148 9.55 RARA RARB
7 retinoic acid receptor signaling pathway GO:0048384 9.54 RARA RARB
8 regulation of myelination GO:0031641 9.52 RARA RARB
9 cellular process GO:0009987 9.51 JUN RRAS2
10 negative regulation of cartilage development GO:0061037 9.46 RARA RARB
11 growth plate cartilage development GO:0003417 9.37 RARA RARB
12 endodermal cell fate specification GO:0001714 9.26 NANOG POU5F1
13 chondroblast differentiation GO:0060591 9.16 FGF4 RARA
14 ventricular cardiac muscle cell differentiation GO:0055012 8.96 RARA RARB
15 glandular epithelial cell development GO:0002068 8.62 RARA RARB

Molecular functions related to Teratocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor activity, sequence-specific DNA binding GO:0003700 9.73 JUN NANOG NR6A1 POU5F1 RARA RARB
2 steroid hormone receptor activity GO:0003707 9.33 NR6A1 RARA RARB
3 sequence-specific DNA binding GO:0043565 9.1 JUN NANOG NR6A1 POU5F1 RARA RARB
4 retinoic acid receptor activity GO:0003708 8.96 RARA RARB

Sources for Teratocarcinoma

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