MCID: TRT001
MIFTS: 43

Teratocarcinoma malady

Cancer diseases category
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Summaries for Teratocarcinoma

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.

MalaCards: Teratocarcinoma, also known as mixed embryonal carcinoma and teratoma, is related to neuronitis and mediastinitis. An important gene associated with Teratocarcinoma is TDGF1 (teratocarcinoma-derived growth factor 1), and among its related pathways are Neural Crest Differentiation and Phospholipase-C Pathway. The compounds tyrosine and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include testis, testis germ and ovary, and related mouse phenotype normal.

Wikipedia:65 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

Aliases & Classifications for Teratocarcinoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

teratocarcinoma 8 10 45 62
mixed embryonal carcinoma and teratoma 8


External Ids:

Disease Ontology8 DOID:3305
MeSH35 D018243
SNOMED-CT58 67830002
NCIt40 C3756

Related Diseases for Teratocarcinoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Teratocarcinoma:



Diseases related to teratocarcinoma

Symptoms for Teratocarcinoma

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Drugs & Therapeutics for Teratocarcinoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Teratocarcinoma

Search NIH Clinical Center for Teratocarcinoma

Genetic Tests for Teratocarcinoma

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Anatomical Context for Teratocarcinoma

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33MalaCards
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MalaCards organs/tissues related to Teratocarcinoma:

33
Testis, Testis germ, Ovary, Bone, Lung, Brain, Colon, Cardiac myocytes, Liver, Heart, Placenta, Kidney, T cells, Pancreas, Pineal, Pituitary, Testes

Animal Models for Teratocarcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Teratocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.9FGF8, TRO, TDGF1, SEPT3, HOXA1

Publications for Teratocarcinoma

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52PubMed
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Articles related to Teratocarcinoma:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
Development of experimental tumors formed by mouse and human embryonic stem and teratocarcinoma cells after subcutaneous and intraperitoneal transplantations into immunodeficient and immunocompetent mice. (23051679)
2013
2
Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea. (22100652)
2011
3
Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. (17716626)
2007
4
Identification and partial characterization of soluble and membrane-bound KDN(deaminoneuraminic acid)-glycoproteins in human ovarian teratocarcinoma PA-1, and enhanced expression of free and bound KDN in cells cultured in mannose-rich media. (16897181)
2006
5
The detection of differentiation-inducing chemicals by using green fluorescent protein expression in genetically engineered teratocarcinoma cells. (16180984)
2005
6
Expression in murine teratocarcinoma F9 cells of transcription factors involved in pancreas development. (15194401)
2004
7
Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. (14990856)
2004
8
Identification and characterization of retinoic acid receptor beta2 target genes in F9 teratocarcinoma cells. (12805409)
2003
9
Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. (12810068)
2003
10
Expression of Sec61 alpha in F9 and P19 teratocarcinoma cells after retinoic acid treatment. (14509846)
2003
11
Apoptosis of the teratocarcinoma cell line Tera-1 leads to the cleavage of HERV-K10gag proteins by caspases and/or granzyme B. (12193232)
2002
12
Retinoic acid treatment enhances the acetylcholine contents in the human teratocarcinoma cell line NTera-2. (11102653)
2000
13
Proadrenomedullin NH(2)-terminal 20 peptide (PAMP) and adrenomedullin bind to teratocarcinoma cells. (10704725)
2000
14
Differential response to exogenous and endogenous activin in a human ovarian teratocarcinoma-derived cell line (PA-1): regulation by cell surface follistatin. (10342830)
1999
15
Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat. (10588714)
1999
16
Human growth-differentiation factor 3 (hGDF3): developmental regulation in human teratocarcinoma cell lines and expression in primary testicular germ cell tumours. (9467948)
1998
17
Expression of teratocarcinoma-derived growth factor-1 (TDGF-1) in testis germ cell tumors and its effects on growth and differentiation of embryonal carcinoma cell line NTERA2/D1. (9285688)
1997
18
Regulation of the laminin beta 1 (LAMB1), retinoic acid receptor beta, and bone morphogenetic protein 2 genes in mutant F9 teratocarcinoma cell lines partially deficient in cyclic AMP-dependent protein kinase activity. (9419418)
1997
19
Testicular microlithiasis associated with teratocarcinoma and intratubular germ cell neoplasia: a case report. (9354962)
1997
20
Dependence of mutation induction on fast-neutron energy in a human epithelial teratocarcinoma cell line (P3). (8927701)
1996
21
A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation. (8673928)
1996
22
A teratocarcinoma-derived neurotrophic activity. (7662906)
1995
23
Ultraviolet irradiation, although it activates the transcription factor AP-1 in F9 teratocarcinoma stem cells, does not induce the full complement of differentiation-associated genes. (7521841)
1994
24
Developmentally regulated expression of two novel platelet-derived growth factor alpha-receptor transcripts in human teratocarcinoma cells. (8261442)
1994
25
Kinetics of in vitro mineralization by an osteogenic clonal cell line (C1) derived from mouse teratocarcinoma. (8405769)
1993
26
Changes in Hox1.6, c-jun, and Oct-3 gene expressions are associated with teratocarcinoma F9 cell differentiation in three different ways of induction. (8453995)
1993
27
Characterization of a DNA-damage-recognition protein from F9 teratocarcinoma cells, which is inducible by retinoic acid and cyclic AMP. (8382473)
1993
28
Retinoic acid modulation of transmembrane signaling. Analysis in F9 teratocarcinoma cells. (2170395)
1990
29
Alterations of cellular characteristics of a human ovarian teratocarcinoma cell line after in vitro treatment with retinoids. (2373285)
1990
30
Milk plasma supports growth and differentiation of a mouse teratocarcinoma cell line. (2732192)
1989
31
Actin cytoskeleton of extraembryonic endoderm and teratocarcinoma-derived endoderm cells. (2553454)
1989
32
Basement membrane matrices in mouse embryogenesis, teratocarcinoma differentiation and in neuromuscular maturation. (2485704)
1989
33
Plasminogen activator expression in F9 teratocarcinoma embryoid bodies and their endoderm derivatives. (2516796)
1989
34
Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells. (2470007)
1989
35
A monoclonal antibody, MA21, recognizes a surface component that is present on F9 teratocarcinoma cells and that appears vectorially on the trophectoderm of peri-implantation-stage mouse blastocysts. (2654386)
1989
36
An early effect of retinoic acid: cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation. (3422432)
1988
37
Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells. (3342876)
1988
38
Isolation of complementary DNA clones for genes exhibiting reduced expression after treatment of mouse teratocarcinoma stem cells with a tumor-promoting phorbol ester. (2821315)
1987
39
Interferon inducibility and sensitivity of human teratocarcinoma-derived cell lines. (2440957)
1987
40
Induction of class I major histocompatibility complex antigens in human teratocarcinoma cells by interferon without induction of differentiation, growth inhibition, or resistance to viral infection. (3026615)
1987
41
Decreased c-myc expression is an early event in retinoic acid-induced differentiation of F9 teratocarcinoma cells. (3526333)
1986
42
Differentiation alters the unstable expression of adenine phosphoribosyltransferase in mouse teratocarcinoma cells. (3783283)
1986
43
Inhibition of gap junctional intercellular communication in human teratocarcinoma cells by organochlorine pesticides. (3952740)
1986
44
Isolation and characterization of the cDNAs corresponding to mRNAs abundant in undifferentiated mouse embryonal teratocarcinoma stem cells, but not in differentiated mouse parietal endoderm cells. (2434467)
1986
45
The outgrowth of parietal endoderm from mouse teratocarcinoma stem-cell embryoid bodies. (2430849)
1986
46
Characterization of three mouse monoclonal antibodies that react with high-molecular-mass glycopeptides isolated from F9 mouse teratocarcinoma cells. (2429884)
1986
47
Trophoblastic differentiation of human teratocarcinoma cell line HT-H1. (2426151)
1986
48
Multipotent mutator strain of mouse teratocarcinoma cells. (3859019)
1985
49
Expression of N-myc in teratocarcinoma stem cells and mouse embryos. (3840574)
1985
50
Molecular biology of embryonic and teratocarcinoma stem cells. Proceedings of an international symposium. Prague, Czechoslovakia, 10-15 September 1984. (6535648)
1984

Variations for Teratocarcinoma

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Expression for genes affiliated with Teratocarcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Teratocarcinoma

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Pathways for genes affiliated with Teratocarcinoma

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50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 30KEGG
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Pathways related to Teratocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9FGF8, HOXA1
2
Show member pathways
9.5RRAS2, TDGF1, FGF8
3
Show member pathways
9.5FGF8, TDGF1, RRAS2
4
Show member pathways
9.5FGF8, TDGF1, RRAS2
5
Show member pathways
9.5FGF8, TDGF1, RRAS2
69.3FGF8, WNT9B, RRAS2

Compounds for genes affiliated with Teratocarcinoma

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45Novoseek, 24HMDB
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Compounds related to Teratocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tyrosine458.8RRAS2, TDGF1, TRO, FGF8, BYSL
2retinoic acid45 249.3FGF8, TDGF1P3, WNT9B, SEPT3, HOXA1

GO Terms for genes affiliated with Teratocarcinoma

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16Gene Ontology
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Biological processes related to Teratocarcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1motor neuron axon guidanceGO:00804510.0FGF8, HOXA1
2gastrulationGO:00736910.0FGF8, TDGF1
3anatomical structure morphogenesisGO:0096539.9FGF8, HOXA1
4BMP signaling pathwayGO:0305099.8FGF8, TDGF1
5male genitalia developmentGO:0305399.8FGF8, WNT9B
6branching involved in ureteric bud morphogenesisGO:0016589.6WNT9B, FGF8
7canonical Wnt signaling pathwayGO:0600709.6FGF8, TDGF1

Molecular functions related to Teratocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.6FGF8, TDGF1P3, TDGF1

Products for genes affiliated with Teratocarcinoma

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Sources for Teratocarcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet