MCID: TRT001
MIFTS: 42

Teratocarcinoma malady

Cancer diseases category

Summaries for Teratocarcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.

MalaCards: Teratocarcinoma, also known as mixed embryonal carcinoma and teratoma, is related to neuronitis and mediastinitis. An important gene associated with Teratocarcinoma is TDGF1 (teratocarcinoma-derived growth factor 1), and among its related pathways is Signaling by NODAL. The compound retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include testis, testis germ and ovary, and related mouse phenotype mortality/aging.

Wikipedia:63 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

Aliases & Classifications for Teratocarcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

teratocarcinoma 8 10 44 60
mixed embryonal carcinoma and teratoma 8


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Disease Ontology8 DOID:3305
NCIt39 C3756
SNOMED-CT56 67830002
MeSH34 D018243

Related Diseases for Teratocarcinoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Teratocarcinoma:



Diseases related to teratocarcinoma

Clinical Features for Teratocarcinoma

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Drugs & Therapeutics for Teratocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Teratocarcinoma

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Anatomical Context for Teratocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Teratocarcinoma:

32
Testis, Testis germ, Ovary, Bone, Lung, Brain, Colon, Pineal, Cardiac myocytes, Liver, Heart, Kidney, Placenta, T cells, Pancreas, Pituitary, Testes

Animal Models for Teratocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Teratocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076810.9TDGF1, CRABP1, TRO, MAP3K12, BYSL, HOXA1

Publications for Teratocarcinoma

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50PubMed
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Articles related to Teratocarcinoma:

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idTitleAuthorsYear
1
Presacral teratocarcinoma presenting as anal fistula and rectal adenocarcinoma: a unique case presentation and literature review. (22611366)
2012
2
Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea. (22100652)
2011
3
Angiogenesis and vascular network of teratocarcinoma from embryonic stem cell transplant into seminiferous tubules. (19513074)
2009
4
Resistance mechanisms following cisplatin and oxaliplatin treatment of the human teratocarcinoma cell line 2102EP. (15868958)
2005
5
Nitrofen induces a redox-dependent apoptosis associated with increased p38 activity in P19 teratocarcinoma cells. (15582350)
2005
6
Laminin-5 suppresses chondrogenic differentiation of murine teratocarcinoma cell line ATDC5. (16165127)
2005
7
Retinoic acid induces parietal endoderm but not primitive endoderm and visceral endoderm differentiation in F9 teratocarcinoma stem cells with a targeted deletion of the Rex-1 (Zfp-42) gene. (12354678)
2002
8
Phenotypic heterogeneity of human endogenous retrovirus particles produced by teratocarcinoma cell lines. (11172100)
2001
9
Retinoic acid treatment enhances the acetylcholine contents in the human teratocarcinoma cell line NTera-2. (11102653)
2000
10
Dual effects of four members of the fibroblast growth factor member family on multiplication and motility in human teratocarcinoma cells in vitro. (11131657)
2000
11
Teratocarcinoma presenting with duodenal metastases diagnosed on endoscopic fine needle aspiration. (10531722)
1999
12
Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3. (10371304)
1999
13
Neurofilament proteins are constitutively expressed in F9 teratocarcinoma cells. (10593619)
1999
14
Localization and expression of integrin subunits in the embryoid bodies of F9 teratocarcinoma cells. (10047453)
1999
15
Identification of a retinoic acid response domain involved in the activation of the beta 1-adrenergic receptor gene by retinoic acid in F9 teratocarcinoma cells. (9448745)
1998
16
Increased expression of c-jun, but not retinoic acid receptor beta, is associated with F9 teratocarcinoma stem cell differentiation induced by polyamine depletion. (9361192)
1997
17
In vitro induction of differentiation by ginsenoides in F9 teratocarcinoma cells. (8869109)
1996
18
Restricted expression of new HERV-K members in human teratocarcinoma cells. (7747445)
1995
19
Further studies on cell adhesion based on Le(x)-Le(x) interaction, with new approaches: embryoglycan aggregation of F9 teratocarcinoma cells, and adhesion of various tumour cells based on Le(x) expression. (7841799)
1994
20
Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design. (7932806)
1994
21
Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids. (8045916)
1994
22
Identification of a major poly-N-acetyllactosamine-containing cell-surface glycoprotein of mouse teratocarcinoma cells. Appearance on cells induced to primitive endoderm but not parietal endoderm differentiation. (8125095)
1994
23
Evidence that HERV-K is the endogenous retrovirus sequence that codes for the human teratocarcinoma-derived retrovirus HTDV. (8356806)
1993
24
Teratocarcinoma F9 cells induced to differentiate with sodium butyrate produce both tissue-type and urokinase-type plasminogen activators. (1644865)
1992
25
Molecular cloning of a mouse 47-kDa heat-shock protein (HSP47), a collagen-binding stress protein, and its expression during the differentiation of F9 teratocarcinoma cells. (1317794)
1992
26
Regulation of the differentiation of teratocarcinoma cells into primitive endoderm by G alpha i2. (1455234)
1992
27
The expression and localization of urokinase-type plasminogen activator and its type 1 inhibitor are regulated by retinoic acid and fibroblast growth factor in human teratocarcinoma cells. (1905574)
1991
28
Overexpression of the cellular retinoic acid binding protein-I (CRABP-I) results in a reduction in differentiation-specific gene expression in F9 teratocarcinoma cells. (1847931)
1991
29
Maintenance and use of F9 teratocarcinoma cells. (1964999)
1990
30
Extragonadal teratocarcinoma derived from embryonal stem cells in chimaeric mice. (2313482)
1990
31
A retinoic acid-responsive gene, MK, found in the teratocarcinoma system. Heterogeneity of the transcript and the nature of the translation product. (2355021)
1990
32
Actin cytoskeleton of extraembryonic endoderm and teratocarcinoma-derived endoderm cells. (2553454)
1989
33
Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells. (2511439)
1989
34
An early effect of retinoic acid: cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation. (3422432)
1988
35
Posttranscriptional regulation of the expression of CAD gene during differentiation of F9 teratocarcinoma cells by induction with retinoic acid and dibutyryl cyclic AMP. (2896607)
1988
36
Inducer mediated in vitro differentiation in a neurogenic transplantable murine teratocarcinoma. (2847981)
1988
37
Induction of class I major histocompatibility complex antigens in human teratocarcinoma cells by interferon without induction of differentiation, growth inhibition, or resistance to viral infection. (3026615)
1987
38
The effect of dibutyryl cyclic AMP and butyrate on F9 teratocarcinoma cellular retinoic acid-binding protein activity. (3031026)
1987
39
Decrease in the c-myb gene transcript during differentiation of mouse teratocarcinoma stem cells. (2840075)
1987
40
Butyrate selectively activates the metallothionein gene in teratocarcinoma cells and induces hypersensitivity to metal induction. (3601676)
1987
41
Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B. (3311384)
1987
42
Collagen expression during teratocarcinoma cell line-induced endochondral bone tumor. (3519748)
1986
43
Latent infection of human ovarian teratocarcinoma cells with human cytomegalovirus. Brief report. (3019280)
1986
44
Cell surface lectins of transplantable human teratocarcinoma cells: purification of a new mannan-specific endogenous lectin. (4048775)
1985
45
Mouse teratocarcinoma and embryonic development. Two-dimensional protein patterns in muscle differentiation. (4043091)
1985
46
An increase in prolyl-4-hydroxylase activity occurs during the retinoic acid-induced differentiation of mouse teratocarcinoma stem cell lines F9 and P19. (2997185)
1985
47
Reactivity of five N-acetylgalactosamine-recognizing lectins with preimplantation embryos, early postimplantation embryos, and teratocarcinoma cells of the mouse. (4018458)
1985
48
Isolation of a teratocarcinoma stem cell lectin implicated in intercellular adhesion. (3987889)
1985
49
Molecular biology of embryonic and teratocarcinoma stem cells. Proceedings of an international symposium. Prague, Czechoslovakia, 10-15 September 1984. (6535648)
1984
50
Intracranial teratocarcinoma in a child with anterior sacral and intrasacral meningocele. (732963)
1978

Genetic Variations for Teratocarcinoma

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Expression for genes affiliated with Teratocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Teratocarcinoma

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Pathways for genes affiliated with Teratocarcinoma

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53Reactome
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Pathways related to Teratocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.6TDGF1, FST

Compounds for genes affiliated with Teratocarcinoma

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44Novoseek, 24HMDB
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Compounds related to Teratocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid44 2411.9TDGF1P3, SEPT3, LAMB1, FST, WNT9B, HOXA1

GO Terms for genes affiliated with Teratocarcinoma

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16Gene Ontology
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Biological processes related to Teratocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:00756610.6LAMB1, TRO
2positive regulation of cell migrationGO:03033510.3TDGF1, LAMB1, RRAS2

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Sources for Teratocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
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