MCID: TRT001
MIFTS: 42

Teratocarcinoma malady

Cancer diseases category

Summaries for Teratocarcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.

MalaCards: Teratocarcinoma, also known as mixed embryonal carcinoma and teratoma, is related to neuronitis and mediastinitis. An important gene associated with Teratocarcinoma is TDGF1 (teratocarcinoma-derived growth factor 1), and among its related pathways is Signaling by NODAL. The compound retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include testis, testis germ and ovary, and related mouse phenotype mortality/aging.

Wikipedia:63 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

Aliases & Classifications for Teratocarcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

teratocarcinoma 8 10 44 60
mixed embryonal carcinoma and teratoma 8


External Ids:

Disease Ontology8 DOID:3305
NCIt39 C3756
SNOMED-CT56 67830002
MeSH34 D018243

Related Diseases for Teratocarcinoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Teratocarcinoma:



Diseases related to teratocarcinoma

Clinical Features for Teratocarcinoma

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Drugs & Therapeutics for Teratocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Teratocarcinoma

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Anatomical Context for Teratocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Teratocarcinoma:

32
Testis, Testis germ, Ovary, Bone, Lung, Brain, Colon, Pineal, Cardiac myocytes, Liver, Heart, Kidney, Placenta, T cells, Pancreas, Pituitary, Testes

Animal Models for Teratocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Teratocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076810.9TDGF1, CRABP1, TRO, MAP3K12, BYSL, HOXA1

Publications for Teratocarcinoma

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50PubMed
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Articles related to Teratocarcinoma:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
Wnt/I^-catenin signaling pathway upregulates c-Myc expression to promote cell proliferation of P19 teratocarcinoma cells. (22976998)
2012
2
Primary CNS teratocarcinoma. (22363315)
2012
3
Teratocarcinoma formation in embryonic stem cell-derived neural progenitor hippocampal transplants. (22776287)
2012
4
Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements. (17875646)
2007
5
The detection of differentiation-inducing chemicals by using green fluorescent protein expression in genetically engineered teratocarcinoma cells. (16180984)
2005
6
Bex3 associates with replicating mitochondria and is involved in possible growth control of F9 teratocarcinoma cells. (15563833)
2004
7
Gene profiling of Frizzled-1 and Frizzled-2 signaling: expression of G-protein-coupled receptor chimeras in mouse F9 teratocarcinoma embryonal cells. (14722236)
2004
8
Transient modulation of cytoplasmic and nuclear retinoid receptors expression in differentiating human teratocarcinoma NT2 cells. (12485405)
2003
9
A novel gene, Jpk, induces apoptosis in F9 murine teratocarcinoma cell through ROS generation. (15033765)
2003
10
Extragonadal teratocarcinoma in chimeric mice. (10490215)
1999
11
Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function. (10559239)
1999
12
Shunt-related abdominal metastasis of cerebral teratocarcinoma: report of an unusual case and review of the literature. (9632200)
1998
13
Analysis of the DNA-binding activities of Myc/Max/Mad network complexes during induced differentiation of U-937 monoblasts and F9 teratocarcinoma cells. (9264414)
1997
14
Resistance of ovarian teratocarcinoma cell spheroids to complement-mediated lysis. (9155042)
1997
15
Dependence of mutation induction on fast-neutron energy in a human epithelial teratocarcinoma cell line (P3). (8927701)
1996
16
A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation. (8673928)
1996
17
Multiparametric analysis of cell differentiation in teratocarcinoma embryoid bodies. (9087797)
1996
18
Murine endodermal F9E cells, derived from the teratocarcinoma line F9, contain high basal levels of retinoic acid receptors (RARs and RXRs) but are not sensitive to the actions of retinoic acid. (8765051)
1996
19
Correlation of ploidy and cyclin B1, P34cdc2 and PCNA expression in F9 teratocarcinoma cells. (9087796)
1996
20
Hinokitiol induces differentiation of teratocarcinoma F9 cells. (8593483)
1995
21
Characterization of protein kinase CK2 protein subunits and p53 in F9 teratocarcinoma cells in the absence and presence of cisplatin. (7735333)
1994
22
Cardiac myocyte differentiation induced by 3,5,3'-triiodo-L-thyronine (T3) in P19 teratocarcinoma cells is accompanied by preferential binding of RGG(T/A)CA direct repeats spaced by 4 base pairs in the DNA. (7811280)
1994
23
Effects of synthetic retinoids and retinoic acid isomers on the expression of alkaline phosphatase in F9 teratocarcinoma cells. (8216300)
1993
24
Retinoic acid stimulates the protein kinase C pathway before activation of its beta-nuclear receptor during human teratocarcinoma differentiation. (8218362)
1993
25
Inhibin subunits, follistatin and activin receptors in the human teratocarcinoma cell line Tera-2. (8389547)
1993
26
Expression and localization of villin, fimbrin, and myosin I in differentiating mouse F9 teratocarcinoma cells. (1601186)
1992
27
Serotonin uptake, storage, and synthesis in an immortalized committed cell line derived from mouse teratocarcinoma. (2155426)
1990
28
Assays for expression of genes regulated by retinoic acid in murine teratocarcinoma cell lines. (1965001)
1990
29
Transfection and expression of syngeneic H-2 genes does not reduce malignancy of H-2 negative teratocarcinoma cells in the autologous host. (2344619)
1990
30
Antibodies as drug carriers for solid tumors: evaluation of drug-anti-SSEA-1 conjugates in the treatment of teratocarcinoma. (1983386)
1990
31
Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells. (2470007)
1989
32
Two purified factors bind to the same sequence in the enhancer of mouse MHC class I genes: one of them is a positive regulator induced upon differentiation of teratocarcinoma cells. (2668878)
1989
33
Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells. (3342876)
1988
34
A human teratocarcinoma which expresses a rare neuronal cell surface antigen. (3315107)
1987
35
Growth and differentiation of teratocarcinoma OTT6050 affected by host hormonal changes in old mice. (3590172)
1987
36
Retinoic acid-induced rapid loss of nuclear cyclic AMP-dependent protein kinase in teratocarcinoma cells. (3664484)
1987
37
Resistance to 402AX teratocarcinoma involves immunity to minor histocompatibility antigens. (3301646)
1987
38
Decreased c-myc expression is an early event in retinoic acid-induced differentiation of F9 teratocarcinoma cells. (3526333)
1986
39
Chimeric potency of a mutator strain of mouse teratocarcinoma cells. (3084422)
1986
40
Conditions affecting the differentiation of F9 teratocarcinoma cells: potentiation of response by cyclic AMP. (2423499)
1986
41
Extraembryonic tissues as sources and sinks of humoral factors in development: teratocarcinoma model systems. (3543953)
1986
42
Constitutive and retinoic acid-inducible expression of cytomegalovirus immediate-early genes in human teratocarcinoma cells. (3009858)
1986
43
The regulation of collagen type IV(alpha 1) and other genes during the retinoic acid induced differentiation of wild type and mutant mouse teratocarcinoma stem cells. (3027712)
1986
44
Sublocalization of c-myb to 6q21----q23 by in situ hybridization and c-myb expression in a human teratocarcinoma with 6q rearrangements. (3007038)
1986
45
Effects of tunicamycin, N-methyl-1-deoxynojirimycin, and manno-1-deoxynojirimycin on the biosynthesis of lactosaminoglycans in F9 teratocarcinoma cells. (2945635)
1986
46
Clonal growth and mesenchymal differentiation of PCC3/A/1 teratocarcinoma cells in serum-free medium. (3995602)
1985
47
A membrane glycoprotein involved in teratocarcinoma cell adhesion to substratum. (3996476)
1985
48
Isoelectric forms of alpha-L-fucosidase in mouse teratocarcinoma-derived cell lines. (2995166)
1985
49
Serological analysis of early mouse embryo with rat monoclonal antibodies produced against mouse teratocarcinoma cells. (3838958)
1985
50
Organization and state of methylation of endogenous type C retroviral sequences in 129 mouse differentiated and undifferentiated teratocarcinoma cell lines. (2984855)
1985

Genetic Variations for Teratocarcinoma

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Expression for genes affiliated with Teratocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Teratocarcinoma

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Pathways for genes affiliated with Teratocarcinoma

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53Reactome
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Pathways related to Teratocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.6TDGF1, FST

Compounds for genes affiliated with Teratocarcinoma

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44Novoseek, 24HMDB
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Compounds related to Teratocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid44 2411.9TDGF1P3, SEPT3, LAMB1, FST, WNT9B, HOXA1

GO Terms for genes affiliated with Teratocarcinoma

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16Gene Ontology
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Biological processes related to Teratocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:00756610.6LAMB1, TRO
2positive regulation of cell migrationGO:03033510.3TDGF1, LAMB1, RRAS2

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Sources for Teratocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
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50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
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