Teratocarcinoma malady

Disease Ontology: A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.⁶

MalaCards: Teratocarcinoma, also known as teratocarcinoma (morphologic abnormality), is related to pediatric cns embryonal cell carcinoma and germ cell tumor. An important gene associated with Teratocarcinoma is TDGF1P3 (teratocarcinoma-derived growth factor 1 pseudogene 3), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Glioma Invasiveness. The compounds threonine and dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and ovary, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Wikipedia: A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or...⁴⁴ more...

Aliases & Descriptions:

teratocarcinoma 6 8 32 43 teratocarcinoma (morphologic abnormality) 6

mixed embryonal carcinoma and teratoma 6 carcinoma, embryonal 43

Diseases related to teratocarcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 495)

id	Related Disease	Score	Top Affiliating Genes
1	pediatric cns embryonal cell carcinoma	30.9	LMNA, BMP2, RARG, RARA, RARS, RARB
2	germ cell tumor	27.9	NANOG, BMP2, RARG, RARB, UTF1, ZFP42
3	congenital heart defect	26.8	SERPINE1, JUN, CD36, FN1, GSR, FGF2
4	herpes simplex	26.1	CNTN2, SERPINE1, LMNA, LMNB1, MYC, RAC1
5	hyperthyroidism	25.5	PCSK2, SERPINE1, CGA, CD36, GSR, ALPP
6	rhabdomyosarcoma	25.4	NCOA3, MYC, RARA, RARB, RAC1, CDKN1A
7	aldosteronism	23.4	SERPINE1, BMP2, CGA, JUN, FST, CD36
8	colon carcinoma	22.3	SERPINE1, LMNA, MYC, MYB, BMP2, RARA
9	alzheimer's disease	21.2	PCSK2, PCSK5, SERPINE1, LMNA, MYC, RARA
10	neuronitis	20.5	CNTN2, PCSK2, PCSK5, SERPINE1, NANOG, LMNA
11	adenoma	20.5	NCOA3, PCSK2, MYC, MYB, BMP2, RARA
12	carcinoma	18.2	NCOA3, CNTN2, PCSK2, BYSL, RBP1, RBP2
13	cleft lip	14.2	RARA, FGF18, FGF3, FGF7, FGF8, FGF9
14	stickler syndrome	14.2	RARA, FGF18, FGF3, FGF7, FGF8, FGF9
15	craniosynostosis	14.2	BMP2, FGF2, FGF4, FGF7, FGF8, FGF9
16	differentiating neuroblastoma	14.1	BMP2, RARA, FOS, ASCL1, APP, MAPT
17	acrocephalosyndactylia	14.1	FGF2, FGF4, FGF7, FGFR2
18	mental retardation syndrome	14.1	CFI, FOS, APP, MAPT, HPRT1, HOXA1
19	early-onset familial alzheimer disease	14.1	APP, MAPT, SNCA, PSEN1
20	congenital diaphragmatic hernia	14.0	RARB, FGF18, FGF2, FGF7, HOXB5, CYP26A1
21	memory impairment	14.0	CHAT, BACE1, APP, MAPT, SNCA, CREB1
22	gliosis	14.0	CHAT, BACE1, FOS, FGF9, APP, MAPT
23	alzheimer disease type 2	14.0	APP, MAPT, PLAU, PSEN1
24	malignant fibrous histiocytoma	14.0	BMP2, MDM2, IGF2, TRO, CREB1, PDGFRA
25	aicardi-goutieres syndrome	14.0	CHAT, BACE1, APP, MAPT, SNCA, TH
26	craniosynostosis, syndromic	13.9	FGF2, FGF7, FGF9, FGFR2
27	fibrous histiocytoma	13.9	BMP2, MDM2, IGF2, TRO, CREB1, PDGFRA
28	dentatorubral-pallidoluysian atrophy	13.9	CASP3, CALB2, CREB1, PVALB
29	thanatophoric dysplasia	13.9	FGF2, FGF3, FGF9, FGFR2
30	vascular dementia	13.9	CHAT, APP, MAPT, SNCA, PSEN1
31	keratomalacia	13.9	RBP1, RARG, RARA, RARS, RARB, FGF3
32	familial idiopathic basal ganglia calcification	13.9	APP, MAPT, PSEN1
33	frontotemporal dementia	13.9	BACE1, JUN, APP, MAPT, SNCA, PSEN1
34	lewy body dementia	13.9	CHAT, APP, MAPT, SNCA, TH
35	histiocytoma	13.9	BMP2, FSCN1, MDM2, IGF2, TRO, CTSB
36	traumatic brain injury	13.9	BMP2, BACE1, JUN, FOS, APP, CASP3
37	motor neuron disease	13.9	CHAT, MAPT, SNCA, PVALB, SYP, NUDT6
38	cerebral hypoxia	13.9	FOS, APP, CASP3, CREB1, PLAT
39	neuroendocrine carcinoma	13.9	FSCN1, ASCL1, CALCA, KRT8, SYP
40	amyloid tumor	13.8	CHAT, BACE1, APP, MAPT, CTSB, SYP
41	sacrococcygeal teratoma	13.8	NANOG, CGA, JUN, POU5F1, AFP, GDNF
42	tauopathy	13.8	APP, MAPT, CASP3, SP1, SNCA, PSEN1
43	epilepsy syndrome	13.8	FLT1, GSR, GRIK2, CALB2, ODC1, CREB1
44	neurilemmoma	13.8	BMP2, RAC1, CALB2, SNCA, PDGFRA, KRT8
45	xeroderma pigmentosum	13.8	LMNA, RARG, GSR, CALB2, CAT, HPRT1
46	carcinoid syndrome	13.8	PCSK2, RARB, FSCN1, ASCL1, CALB2, CALCA
47	transient cerebral ischemia	13.8	JUN, FOS, GSR, MAPT, CASP3, DYT10
48	sudden infant death syndrome	13.8	BMP2, CHAT, FOS, ASCL1, CASP3, TH
49	abrikosov's tumor	13.8	CGA, FSCN1, INHBA, CALB2, PDGFRA, KRT8
50	neuroendocrine tumor	13.8	ASCL1, CCNB1, CALCA, PDGFRA, KRT8, SYP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to teratocarcinoma:

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MGI Mouse Phenotypes related to teratocarcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.4	PCSK2, RARG, ZFP42, B4GALT1, ASCL1, FGF8
2	respiratory system phenotype	MP:0005388	10.2	PCSK5, B4GALT1, FST, FOXD3, ASCL1, FGF18
3	craniofacial phenotype	MP:0005382	10.0	NCOA3, PCSK5, LMNB1, RARG, PBX2, T
4	other phenotype	MP:0005395	9.8	RBP2, SERPINH1, RARG, RARA, RARB, BACE1
5	pigmentation phenotype	MP:0001186	9.7	RBP1, LMNA, MYC, RAC1, ITGB1, ASCL1
6	liver/biliary system phenotype	MP:0005370	9.5	NCOA3, RBP1, MYB, CD36, HPRT1, NR2C2
7	no phenotypic analysis	MP:0003012	9.5	PCSK5, NANOG, MYC, BACE1, T, ASCL1
8	limbs/digits/tail phenotype	MP:0005371	9.5	PCSK5, LMNA, BMP2, RARA, RARB, RAC1
9	embryogenesis phenotype	MP:0005380	9.2	NCOA3, NANOG, LMNB1, MYC, MYB, RARG
10	hematopoietic system phenotype	MP:0005397	9.0	RBP1, PBX2, MXD1, B4GALT1, FUT4, CDKN1A
11	renal/urinary system phenotype	MP:0005367	9.0	NCOA3, PCSK5, LMNA, RARA, RARB, CFI
12	normal phenotype	MP:0002873	8.8	SEPT3, LMNA, MYC, MYB, BMP2, RARG
13	hearing/vestibular/ear phenotype	MP:0005377	8.7	NCOA3, RBP1, LMNA, MYC, BMP2, RARG
14	reproductive system phenotype	MP:0005389	8.4	NCOA3, PCSK2, RBP1, LMNA, BMP2, RARG
15	immune system phenotype	MP:0005387	8.4	NCOA3, PCSK5, RBP1, LMNA, MYB, RARG
16	skeleton phenotype	MP:0005390	8.2	PCSK5, LMNA, MYC, BMP2, RARG, RARA
17	vision/eye phenotype	MP:0005391	8.2	RBP1, LMNA, RARG, RARA, RARB, LAMA1
18	adipose tissue phenotype	MP:0005375	7.7	NCOA3, SERPINE1, LMNA, MYC, B4GALT1, CDKN1A
19	muscle phenotype	MP:0005369	7.4	NCOA3, LMNA, LMNB1, MYC, RARA, RARB
20	nervous system phenotype	MP:0003631	7.3	CNTN2, PCSK5, RBP1, SEPT3, SERPINH1, LMNA
21	integument phenotype	MP:0010771	7.2	NCOA3, PCSK2, LMNB1, MYC, MYB, RARG
22	behavior/neurological phenotype	MP:0005386	7.1	NCOA3, CNTN2, PCSK2, LMNA, RARB, CHAT
23	digestive/alimentary phenotype	MP:0005381	7.1	NCOA3, PCSK5, RBP2, LMNA, MYC, BMP2
24	tumorigenesis	MP:0002006	7.0	NCOA3, SERPINE1, MYC, RARA, CDKN1A, ITGB1
25	cardiovascular system phenotype	MP:0005385	6.5	PCSK2, PCSK5, SERPINE1, LMNA, MYC, MYB
26	mortality/aging	MP:0010768	6.4	PCSK2, PCSK5, BYSL, SERPINH1, SERPINE1, NANOG
27	cellular phenotype	MP:0005384	6.3	NCOA3, PCSK2, NANOG, LMNA, LMNB1, MYC
28	growth/size phenotype	MP:0005378	5.2	NCOA3, PCSK5, RBP1, SERPINE1, LMNA, LMNB1
29	homeostasis/metabolism phenotype	MP:0005376	5.0	NCOA3, PCSK2, RBP1, RBP2, SERPINE1, LMNA

Articles related to teratocarcinoma:

(show top 50)    (show all 99)

id	Title	Authors	Year	Affiliating Genes
1	Teratocarcinoma-derived growth factor-1 is upregulate d in aldosterone-producing adenomas and increases aldosterone secretion and inh ibits apoptosis in vitro. (20385969)	Williams T.A.... Mulatero P.	2010	CASP3, TDGF1
2	Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells. (18237746)	Xu J.... Gudas L.J.	2008	SOCS3
3	22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. (17689017)	Yao Z.X.... Papadopoulos V.	2007	APP, GFRA2
4	Nitrofen induces a redox-dependent apoptosis associated with increased p38 activity in P19 teratocarcinoma cells. (15582350)	Kling D.E.... Schnitzer J.J.	2005	CASP3
5	Identification and characterization of retinoic acid receptor beta2 target genes in F9 teratocarcinoma cells. (12805409)	Zhuang Y.... Gudas L.J.	2003	RARB, DAB2, RARS
6	Transient modulation of cytoplasmic and nuclear retinoid receptors expression in differentiating human teratocarcinoma NT2 cells. (12485405)	Borghi R.... Tosetti F.	2003	RARB, CRABP1, RBP1
7	Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. (12810068)	Lopatina N.G.... Tollefsbol T.O.	2003	TERT
8	Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation. (12871956)	Longobardi E.... Blasi F.	2003	PKNOX1, PBX2
9	CCK processing by pituitary GH3 cells, human teratocarcinoma cells NT2 and hNT differentiated human neuronal cells evidence for a differentiation-induced change in enzyme expression and pro CCK processing. (11883703)	Beinfeld M.C.... Wang W.	2002	PCSK2, PCSK5
10	Effects of insulin-like growth factor-binding protein 2 and an IGF-type I receptor-blocking antibody on apoptosis in human teratocarcinoma cells in vitro. (11482908)	Granerus M.... EngstrAPm W.	2001	IGF2
11	A truncated form of teratocarcinoma-derived growth factor-1 (cripto-1) mRNA expressed in human colon carcinoma cell lines and tumors. (11553858)	Baldassarre G.... Persico M.G.	2001	TDGF1
12	Brachyury is expressed by human teratocarcinoma cells in the absence of mesodermal differentiation. (10768863)	Gokhale P.J.... Andrews P.W.	2000	T
13	Retinoic acid treatment enhances the acetylcholine co ntents in the human teratocarcinoma cell line NTera-2. (11102653)	Fischer H.S.... Saria A.	2000	CHAT, NPY
14	Proadrenomedullin NH(2)-terminal 20 peptide (PAMP) and adrenomedullin bind to teratocarcinoma cells. (10704725)	Moody T.W.... Montuenga L.M.	2000	ADM
15	ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells. (10049360)	Antic D.... Keene J.D.	1999	NEFM, ELAVL2
16	Differential response to exogenous and endogenous activin in a human ovarian teratocarcinoma-derived cell line (PA-1): regulation by cell surface follistatin. (10342830)	Delbaere A.... Schneyer A.L.	1999	FST, INHBA
17	Neuronal differentiation of NT2/D1 teratocarcinoma cells is accompanied by a loss of lamin A/C expression and an increase in lamin B1 expression. (10364436)	Pierce T.... Holy J.	1999	LMNA, LMNB1
18	Differentiation of human pluripotent teratocarcinoma stem cells induced by bone morphogenetic protein-2. (10612460)	Pera M.F.... Herszfeld D.	1998	BMP2
19	Human growth-differentiation factor 3 (hGDF3): developmental regulation in human teratocarcinoma cell lines and expression in primary testicular germ cell tumours. (9467948)	Caricasole A.A.... van den Eijnden-van Raaij A.J.	1998	GDF3
20	Increased expression of c-jun, but not retinoic acid receptor beta, is associated with F9 teratocarcinoma stem cell differentiation induced by polyamine depletion. (9361192)	Bjersing J.L.... Heby O.	1997	ODC1, JUN, RARB
21	Regulation of the laminin beta 1 (LAMB1), retinoic acid receptor beta, and bone morphogenetic protein 2 genes in mutant F9 teratocarcinoma cell lines partially deficient in cyclic AMP-dependent protein kinase activity. (9419418)	Shen J.... Gudas L.J.	1997	BMP2, RARB, LAMB1
22	Retinoic acid abolishes the calcitonin gene-related peptide autocrine system in F9 teratocarcinoma cells. (9057102)	Segond N.... Evain-Brion D.	1997	CALCA
23	Aggregates of a beta-amyloid peptide are required to induce calcium currents in neuron-like human teratocarcinoma cells: relation to Alzheimer's disease. (9030407)	Sanderson K.L.... Ingram V.M.	1997	APP
24	A two-site monoclonal antibody immunoradiometric assay for human follistatin: secretion by a human ovarian teratocarcinoma-derived cell line (PA-1). (8636347)	Wang Q.F.... Sluss P.M.	1996	FST
25	Correlation of ploidy and cyclin B1, P34cdc2 and PCNA expression in F9 teratocarcinoma cells. (9087796)	Baroja A.... Arechaga J.	1996	CCNB1
26	Saporin toxins directed to basic fibroblast growth factor receptors effectively target human ovarian teratocarcinoma in an animal model. (8630880)	Davol P.... Frackelton A.R.	1995	NUDT6
27	Induction by adenovirus-5 E1A of the differentiation phenotype of F9 teratocarcinoma cells involves a conserved region (CR1) of E1A. (7742380)	Li H.O.... Yokoyama K.	1995	LAMB1
28	The beta 1, 4-galactosyltransferase gene is post-transcriptionally regulated during differentiation of mouse F9 teratocarcinoma cells. (7579794)	Kudo T.... Narimatsu H.	1995	B4GALT1
29	The kinetics of induction of Hox1.6 and C-jun mRNA during three different ways of inducing differentiation in teratocarcinoma F9 cells. (8589890)	Iwai S.A.... Nishimune Y.	1995	JUN
30	Ultraviolet irradiation, although it activates the transcription factor AP-1 in F9 teratocarcinoma stem cells, does not induce the full complement of differentiation-associated genes. (7521841)	Auer H.P.... Rahmsdorf H.J.	1994	JUN
31	Characterization of conventional protein kinase C (PKC) isotype expression during F9 teratocarcinoma differentiation. Overexpression of PKC alpha alters the expression of some differentiation-dependent genes. (7961696)	Kindregan H.C.... Niles R.M.	1994	PRKCA
32	Autocrine downregulation of fibroblast growth factor receptors in F9 teratocarcinoma cells. (8077293)	Moscatelli D.	1994	FGF2
33	Developmentally regulated expression of two novel platelet-derived growth factor alpha-receptor transcripts in human teratocarcinoma cells. (8261442)	Mosselman S.... Van Zoelen E.J.	1994	PDGFRA
34	Expression of prelamin A but not mature lamin A confe rs sensitivity of DNA biosynthesis to lovastatin on F9 teratocarcinoma cells. (7983180)	Sinensky M.... Fantle K.	1994	LMNA
35	Effects of synthetic retinoids and retinoic acid isomers on the expression of alkaline phosphatase in F9 teratocarcinoma cells. (8216300)	Gianni M.... Garattini E.	1993	RARA, RARB, ALPP
36	Cooperation between retinoic acid and phorbol esters enhances human teratocarcinoma differentiation. (8243888)	Kurie J.M.... Dmitrovsky E.	1993	PRKCA, JUN, RARB
37	9-cis and all-trans retinoic acid induce a similar phenotype in human teratocarcinoma cells. (8243889)	Kurie J.M.... Dmitrovsky E.	1993	RXRA
38	Inhibin subunits, follistatin and activin receptors in the human teratocarcinoma cell line Tera-2. (8389547)	de Jong F.H.... Van Zoelen E.J.	1993	ACVR2B, FST
39	Concentration-dependent modulation of basic fibroblast growth factor action on multiplication and locomotion of human teratocarcinoma cells. (1312020)	Schofield P.N.... EngstrAPm W.	1992	FGF2
40	Gene activation mediated by protein kinase C in human macrophage and teratocarcinoma cells expressing aminoglycoside phosphotransferase activity. (1660486)	Maio J.J.... Brown F.L.	1991	CAT
41	Secretion of polypeptides related to epidermal growth factor and insulinlike growth factor I by a human teratocarcinoma cell line. (1660868)	Jing N.H.... Sakakura T.	1991	EGF
42	Transcription factor Sp1 is important for retinoic acid-induced expression of the tissue plasminogen activator gene during F9 teratocarcinoma cell differentiation. (2172788)	Darrow A.L.... Strickland S.	1990	PLAT, SP1
43	Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. (2108320)	Drivas G.T.... D'Eustachio P.	1990	RAC1, RAN, RRAS2
44	A retinoic acid-inducible mRNA from F9 teratocarcinoma cells encodes a novel protease inhibitor homologue. (2394749)	Wang S.Y.... Gudas L.J.	1990	LAMB1, SPINT2
45	Cyclic AMP analogs and retinoic acid influence the expression of retinoic acid receptor alpha, beta, and gamma mRNAs in F9 teratocarcinoma cells. (2152965)	Hu L.... Gudas L.J.	1990	RARA, RARB, RARS
46	Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. (2792079)	Ciccodicola A.... Persico M.G.	1989	TDGF1
47	Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells. (2470007)	Brooks S.... Peters G.	1989	FGF3
48	A teratocarcinoma glycoprotein carrying a developmentally regulated carbohydrate marker is a member of the immunoglobulin gene superfamily. (2963822)	Ozawa M.... Muramatsu T.	1988	EMB
49	Messenger RNA expressed in mouse teratocarcinoma stem cells and down-regulated by a tumor-promoting phorbol ester codes for a novel transmembrane protein. (3202867)	Akagi J.... Akagi M.	1988	TMEM165
50	Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos. (4075393)	Hauser C.A.... Tjian R.	1985	HOXB5

Genes related to teratocarcinoma according to GeneCards:

(show top 50)    (show all 168)

id	Symbol	Description	Score	GeneCards Section Context
1	TDGF1P3	teratocarcinoma-derived growth factor 1 pseudogene 3	11.0	Proteins, Aliases & Descriptions, Transcripts, Publications
2	SEPT3	septin 3	11.0	Summaries, Disorders
3	BYSL	bystin-like	11.0	Summaries
4	TDGF1P5	teratocarcinoma-derived growth factor 1 pseudogene 5	11.0	Aliases & Descriptions, Publications
5	TDGF1P6	teratocarcinoma-derived growth factor 1 pseudogene 6	11.0	Publications, Aliases & Descriptions
6	TDGF1P7	teratocarcinoma-derived growth factor 1 pseudogene 7	11.0	Aliases & Descriptions, Publications
7	TDGF1P4	teratocarcinoma-derived growth factor 1 pseudogene 4	11.0	Publications, Aliases & Descriptions
8	TDGF1P2	teratocarcinoma-derived growth factor 1 pseudogene 2	11.0	Aliases & Descriptions, Publications
9	TDGF1P1	teratocarcinoma-derived growth factor 1 pseudogene 1	11.0	Aliases & Descriptions
10	TDGF1	teratocarcinoma-derived growth factor 1	11.0	Orthologs, Transcripts, Databases, Publications (show all 5 sections) Aliases & Descriptions
11	RRAS2	related RAS viral (r-ras) oncogene homolog 2	11.0	Publications, Aliases & Descriptions
12	WNT9B	wingless-type MMTV integration site family, member 9B	11.0	Summaries
13	CRABP1	cellular retinoic acid binding protein 1	11.0	Publications
14	TROAP	trophinin associated protein (tastin)	11.0
15	FST	follistatin	11.0	Publications
16	TRO	trophinin	11.0
17	LAMB1	laminin, beta 1	11.0	Publications
18	LBX1	ladybird homeobox 1	11.0
19	MAP3K12	mitogen-activated protein kinase kinase kinase 12	11.0
20	ASCL1	achaete-scute complex homolog 1 (Drosophila)	11.0
21	FGF4	fibroblast growth factor 4	11.0
22	HOXA1	homeobox A1	11.0
23	FGF8	fibroblast growth factor 8 (androgen-induced)	11.0	Publications
24	RARG	retinoic acid receptor, gamma	11.0	Publications
25	FGF7	fibroblast growth factor 7	11.0	Publications
26	RARB	retinoic acid receptor, beta	11.0	Publications
27	ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	11.0	Publications
28	ERVK-6	endogenous retrovirus group K, member 6	11.0	Publications
29	POU5F1	POU class 5 homeobox 1	11.0	Publications
30	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	11.0
31	PVALB	parvalbumin	11.0	Publications
32	WNT2	wingless-type MMTV integration site family member 2	11.0
33	DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	11.0	Publications
34	ODC1	ornithine decarboxylase 1	11.0	Publications
35	NR6A1	nuclear receptor subfamily 6, group A, member 1	11.0	Publications
36	CNTN2	contactin 2 (axonal)	11.0
37	RARA	retinoic acid receptor, alpha	11.0	Publications
38	HBEGF	heparin-binding EGF-like growth factor	11.0	Publications
39	ADAR	adenosine deaminase, RNA-specific	11.0
40	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications
41	BMP2	bone morphogenetic protein 2	11.0	Publications
42	GDNF	glial cell derived neurotrophic factor	11.0
43	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.0	Publications
44	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
45	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	11.0
46	CALB2	calbindin 2	11.0
47	KRT8	keratin 8	11.0
48	SYP	synaptophysin	11.0
49	EGR1	early growth response 1	11.0
50	NR2C2	nuclear receptor subfamily 2, group C, member 2	11.0

Pathways related to teratocarcinoma according to GeneDecks:

(show top 50)    (show all 128)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.7	TDGF1, FGF7, FGF18, FGF4
2	Glioma Invasiveness36	10.7	RRAS2, NUDT6, TDGF1, TGFA, PLAU, FGF8
3	PPAR Pathway36	10.6	FGF8, FGF7, FGF4, FGF2, FLT1, BMP2
4	CREB Pathway36	10.4	CREB1, PDGFRA, PRKCG, PRKCA, NUDT6, BMP2
5	ERK5 Signaling36	10.3	NUDT6, TDGF1, TGFA, CREB1, IGF2, FGF8
6	14-3-3 Induced Intracellular Signaling36	10.3	PDGFRA, FLT1, JUN, BMP2, FGF18, FGF2
7	Akt Signaling36	10.1	FGF7, ACVR2B, PDGFRA, MDM2, FGF8, FGF4
8	FGF Pathway36	10.0	FGF7, FGF4, FGF3, FGF18, RAC1, FGF8
9	Nanog in Mammalian ESC Pluripotency36	10.0	PDGFRA, EGF, TGFA, TDGF1, NUDT6, POU5F1
10	Renin-Angiotensin Pathway36	10.0	PRKCA, PRKCG, NUDT6, RRAS2, RAC1, FGF8
11	Ras Pathway36	10.0	BMP2, IGF2, FGFR2, FGF7, FGF4, FGF2
12	DHA Signaling36	9.9	NUDT6, IGF2, MAPT, APP, FGFR2, FGF7
13	Rac1 Pathway36	9.9	FGF18, RAC1, JUN, ITGB1, FGF4, FGF7
14	Estrogen Pathway36	9.8	FGF4, FGF2, FGF18, FLT1, TGFA, JUN
15	Activation of PKA through GPCR36	9.8	CREB1, FGF7, FGF4, FGF2, FLT1, ADRB1
16	Breast Cancer Regulation by Stathmin136	9.8	TDGF1, FGF7, PRKCG, NUDT6, FGF2, BMP2
17	Development_Role of Activin A in cell differentiation and proliferation41	9.7	NANOG, MYC, MXD1, CGA, CDKN1A, SP1
18	Development Role of Activin A in cell differentiation and proliferation10	9.7	POU5F1, ACVR2B, PKNOX1, CREB1, SP1, INHBA
19	Cell adhesion_ECM remodeling41	9.7	SERPINE1, PLAU, PLAT, IGF2, FN1, ITGB1
20	p53 Mediated Apoptosis36	9.7	TGFA, NUDT6, FGF4, FGF2, FGF18, FLT1
21	Cell adhesion ECM remodeling10	9.7	PLAU, HBEGF, NID1, COL4A1, SERPINE1, LAMA1
22	Apoptotic Pathways in Synovial Fibroblasts36	9.7	FLT1, FGF2, FGF4, FGF7, FGF8, FGFR2
23	Telomerase Components in Cell Signaling36	9.7	BMP2, PRKCG, FLT1, FGF18, FGF2, FGF7
24	Paxillin Interactions36	9.7	RRAS2, EPHB2, BMP2, RAC1, ITGB1, FLT1
25	Nuclear Receptor Activation by Vitamin-A36	9.7	RARG, NUDT6, BMP2, NCOA3, TDGF1, TGFA
26	P2Y Receptor Signaling36	9.6	JUN, FGF3, FGF2, FGF18, FLT1, MYC
27	RhoGDI Pathway36	9.5	FGF9, FGF7, FGF8, FGFR2, CASP3, EGF
28	ILK Signaling36	9.5	PDGFRA, TGFA, FGF7, FGF8, FGFR2, IGF2
29	JAK-STAT Pathway36	9.5	PDGFRA, EGF, TGFA, NUDT6, SOCS3, RRAS2
30	mTOR Pathway36	9.3	EGF, FGF18, BMP2, RAC1, EPHB2, RRAS2
31	Melanoma20	9.3	FGF9, CDKN1A, MDM2, PDGFRA, FGF3, EGF
32	Intracellular Calcium Signaling36	9.3	FGF18, FLT1, IGF2, RRAS2, EPHB2, PRKCA
33	Mitochondrial Apoptosis36	9.3	IGF2, CASP3, PDGFRA, FLT1, EGF, TGFA
34	GPCR Pathway36	9.3	FGF18, FGF2, FGF4, FGF7, FGFR2, FGF8
35	Cellular Apoptosis Pathway36	9.2	FLT1, PDGFRA, EGF, TGFA, TDGF1, PRKCG
36	p70S6K Signaling36	9.2	TDGF1, PRKCG, PRKCA, NUDT6, RRAS2, FGF2
37	Rho Family GTPases36	9.1	FGF4, PDGFRA, IGF2, FGF8, BMP2, RAC1
38	Pancreatic Adenocarcinoma36	9.1	FGF8, TGFA, TDGF1, NUDT6, EPHB2, CDKN1A
39	Activation of PKC through GPCR36	9.1	CREB1, PDGFRA, EGF, TGFA, BMP2, RAC1
40	MAPK signaling pathway20	9.1	PDGFRA, EGF, MAP3K12, RRAS2, PRKCG, CASP3
41	p38 Signaling36	9.0	IGF2, TGFA, BMP2, RAC1, FLT1, PDGFRA
42	PTEN Pathway36	9.0	EGF, PDGFRA, BMP2, RAC1, FN1, FLT1
43	Tec Kinases Signaling36	9.0	BMP2, FGF7, TGFA, PRKCA, PRKCG, TDGF1
44	Antioxidant Action of Vitamin-C36	8.9	TDGF1, PRKCG, PRKCA, NUDT6, RRAS2, RAC1
45	NF-KappaB Family Pathway36	8.9	FGF4, FGF7, FGF8, FGFR2, IGF2, EGF
46	Phospholipase-C Pathway36	8.7	PDGFRA, RAC1, LAMA1, LAMB1, ITGB1, FLT1
47	ERK Signaling36	8.7	IGF2, MAX, FGFR2, FGF8, FGF7, FGF4
48	MAPK Signaling36	8.5	FGFR2, IGF2, CREB1, COL4A1, PDGFRA, EGF
49	Pathways in cancer20	7.6	PDGFRA, CTNNA2, COL4A1, RXRA, MYC, FGF8
50	Molecular Mechanisms of Cancer36	7.6	ACVR2B, EGF, PDGFRA, COL4A1, CTNNA2, CASP3

Compounds related to teratocarcinoma according to GeneDecks:

(show top 50)    (show all 305)

id	Compound	Score	Top Affiliating Genes
1	threonine32	10.7	BMP2, FGFR2, MAPT, MAP3K12, CCNB1, KRT8
2	dopamine32 9 18 9	13.5	BMP2, RARB, CHAT, CGA, FOS, ASCL1
3	ly29400232	10.3	RARA, JUN, FOS, FN1, GZMB, FGF2
4	h2o232	10.2	CNTN2, MYB, RAN, BACE1, CGA, FGFR2
5	n-(4-hydroxyphenyl)retinamide32	9.8	CNTN2, RBP1, MYC, RARG, RARA, RARS
6	gnrh32	9.8	SERPINE1, FST, ODC1, SP1, CREB1, PLAU
7	aspartate32	9.7	RARA, CHAT, BACE1, CGA, GZMB, GSR
8	kainate32	9.6	CHAT, JUN, FOS, GSR, GRIK2, MAPT
9	zinc32 18	10.4	CNTN2, LMNA, MYB, RARA, RARB, RAN
10	vitamin a32 9 18 9	12.3	RBP1, RBP2, MYC, RARG, RARA, RARS
11	ribonucleic acid32	9.2	PCSK2, MYC, BMP2, RARA, RARB, CGA
12	cyclic amp32 18	10.2	PCSK2, RARS, RARB, CGA, JUN, FOS
13	agar32	9.1	CNTN2, RARA, RARB, RAC1, FST, FN1
14	acetylcholine32 9 18 9	12.1	RAC1, CHAT, BACE1, CGA, FGF7, APP
15	bromodeoxyuridine32	8.8	NCOA3, CNTN2, MYC, MYB, RARS, FST
16	etoposide32 42 9 9	11.7	CNTN2, LMNB1, MYC, RARA, CGA, JUN
17	oligonucleotide32	8.7	CNTN2, SERPINH1, MYC, MYB, BMP2, RARA
18	rapamycin32 42	9.7	MYB, BMP2, FN1, GZMB, FLT1, FGF7
19	sb 20358032 42	9.7	BMP2, RAC1, CDKN1A, CD36, ITGB1, FOS
20	arginine32	8.6	NCOA3, CNTN2, PCSK2, MYB, BMP2, RARA
21	glutamate32	8.5	CNTN2, CHAT, BACE1, FOS, GZMB, GSR
22	alanine32	8.5	CNTN2, LMNA, MYC, MYB, BMP2, RARA
23	steroid32	8.5	NCOA3, CNTN2, RBP1, MYB, BMP2, RARA
24	glutamine32	8.5	NCOA3, MYB, CD36, ITGB1, FN1, FGF7
25	lactate32	8.4	BMP2, CHAT, CGA, FST, FN1, GZMB
26	vitamin d32	8.2	NCOA3, SERPINE1, BMP2, RARA, RARS, RARB
27	phorbol32	8.2	MYC, MYB, RAC1, JUN, CDKN1A, FOS
28	tgf beta132	8.2	SERPINE1, BMP2, RARA, FST, CDKN1A, CD36
29	forskolin32 42 9 9	11.1	CNTN2, BMP2, RARS, RARB, RAC1, CHAT
30	12-o-tetradecanoylphorbol 13-acetate32	8.1	CNTN2, MYC, RARA, RARS, RARB, FSCN1
31	progesterone32 42 9 18 9	12.1	NCOA3, RBP1, MYB, BMP2, RARA, RARS
32	testosterone32 9 18 9	10.9	NCOA3, SERPINE1, BMP2, RARA, RARS, RARB
33	cysteine32	7.9	CNTN2, LMNB1, MYB, RARA, RARB, RAN
34	gf 109203x32 42	8.8	JUN, CDKN1A, FOS, FN1, FGF2, APP
35	ibmx32	7.8	PCSK2, BMP2, RARB, CGA, FST, FN1
36	adenylate32	7.7	SERPINE1, MYB, RARB, CGA, FST, FOS
37	heparin32 9 18 9	10.7	SERPINE1, BACE1, LAMA1, CGA, FST, CD36
38	paraffin32	7.6	RBP1, MYC, CHAT, CGA, FSCN1, CDKN1A
39	tamoxifen32 34 9 9	10.6	NCOA3, MYC, RARA, CGA, JUN, CDKN1A
40	genistein32 9 18 9	10.4	SERPINE1, MYC, BMP2, RARB, RAC1, JUN
41	estrogen32	7.3	NCOA3, RBP1, SERPINE1, BMP2, RARG, RARA
42	thymidine32 18	8.2	CNTN2, RBP2, MYC, MYB, BMP2, RARA
43	phosphatidylinositol32	7.2	NCOA3, MYC, RARA, RAN, RAC1, CHAT
44	pd 98,05932	7.2	SERPINE1, MYC, BMP2, RARA, RAC1, CHAT
45	cisplatin32 34 9 9	9.9	MYC, RARB, RAN, RAC1, CGA, CFI
46	vegf32	6.7	CNTN2, SERPINH1, SERPINE1, MYC, BMP2, RAC1
47	actinomycin d32	6.5	SERPINE1, MYC, MYB, BMP2, RARA, RARB
48	tyrosine32	5.8	NCOA3, CNTN2, PCSK2, BYSL, SERPINH1, LMNB1
49	cycloheximide32	5.3	NCOA3, CNTN2, SERPINE1, MYC, MYB, BMP2
50	serine32	4.5	CNTN2, PCSK2, PCSK5, SEPT3, SERPINH1, SERPINE1

Cellular components related to teratocarcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:009986	10.0	ALPP, PLAT, PLAU, ACVR2B, HBEGF, TGFA
2	axon	GO:030424	9.3	EPHB2, NEFM, PVALB, RXRA, SNCA, CTNNA2
3	extracellular matrix	GO:031012	9.2	PLAT, COL4A1, NID1, WNT2, IGFBP7, FGFR2
4	nucleoplasm	GO:005654	8.8	TERT, SP1, SP100, NR2C2, NR6A1, CREB1
5	Golgi apparatus	GO:005794	8.4	FGFR2, APP, CAT, TMEM165, PTHLH, TFAP2A
6	nucleus	GO:005634	8.0	NR2C2, SNCA, SMEK2, CRABP2, CREB1, SP100
7	extracellular region	GO:005576	7.9	PLAU, PLAT, SNCA, SPINT2, PTHLH, CALCA
8	extracellular space	GO:005615	7.1	GDF3, IGFBP7, CALCA, PTHLH, CTSB, PLAT
9	cytoplasm	GO:005737	6.9	SNCA, CRABP1, CRABP2, PLAT, PKNOX1, PDGFRA

Biological processes related to teratocarcinoma according to GeneDecks:

(show all 43)

id	Name	GO ID	Score	Top Affiliating Genes
1	insulin receptor signaling pathway	GO:008286	10.9	RHOQ, IGF2, FGFR2, FGF9, FGF8, FGF7
2	thyroid-stimulating hormone-secreting cell differentiation	GO:060129	10.9	FGF8, FGF2, BMP2
3	corticotropin hormone secreting cell differentiation	GO:060128	10.8	FGF8, FGF2, BMP2
4	negative regulation of neuron apoptotic process	GO:043524	10.8	GDNF, PRKCG, PSEN1, TGFA, SNCA, GRIK2
5	BMP signaling pathway	GO:030509	10.8	TDGF1, ACVR2B, EGR1, FGF8, T, BMP2
6	organ induction	GO:001759	10.8	GDNF, FGF8, FGF3, FGF2
7	response to retinoic acid	GO:032526	10.8	WNT9B, RXRA, SP100, ASCL1, RARA, RARG
8	embryonic skeletal system morphogenesis	GO:048704	10.8	PDGFRA, HOXB5, HOXB1, HOXA7, HOXA5, HOXA4
9	neuron apoptotic process	GO:051402	10.8	PSEN1, CASP3, MAX, APP, GRIK2
10	branching involved in salivary gland morphogenesis	GO:060445	10.8	FGFR2, FGF8, FGF7, LAMA1
11	anatomical structure morphogenesis	GO:009653	10.7	POU5F1, TH, HOXB5, HOXA4, HOXA1, FGF8
12	SMAD protein signal transduction	GO:060395	10.7	AFP, FOS, JUN, T, BMP2
13	positive regulation of cell migration	GO:030335	10.6	RRAS2, TDGF1, HBEGF, PDGFRA, FLT1, ITGB1
14	retinoic acid receptor signaling pathway	GO:048384	10.6	RXRA, SP100, CYP26A1, RARA, RARG
15	lung development	GO:030324	10.5	WNT2, ACVR2B, SP1, FGFR2, FGF2, FGF18
16	positive regulation of epithelial cell proliferation	GO:050679	10.5	TGFA, FGFR2, FGF9, FGF7, LAMB1, MYC
17	anterior/posterior pattern specification	GO:009952	10.5	HOXB1, HOXB5, CYP26A1, ACVR2B, HOXA7, HOXA5
18	positive regulation of cell division	GO:051781	10.5	TGFA, CAT, IGF2, FGFR2, FGF9, FGF8
19	canonical Wnt receptor signaling pathway	GO:060070	10.4	WNT2, TDGF1, FGF8, T, RARG, MYC
20	cardiac muscle cell differentiation	GO:055007	10.4	TDGF1, ITGB1, T, BMP2
21	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.4	PRKCA, PDGFRA, FGFR2, FGF4, FGF2, FGF18
22	branching involved in ureteric bud morphogenesis	GO:001658	10.4	GDNF, FGF8, FGF2, BMP2, MYC
23	thyroid gland development	GO:030878	10.3	CGA, FGF8, HOXA3, HOXA5
24	fibroblast growth factor receptor signaling pathway	GO:008543	10.3	FGFR2, MDM2, CREB1, PRKCG, PRKCA, FGF9
25	positive regulation of fibroblast proliferation	GO:048146	10.2	WNT2, TDGF1, PDGFRA, CDKN1A, JUN, MYC
26	positive regulation of MAPK cascade	GO:043410	10.1	IGF2, FGFR2, FGF9, FLT1, ITGB1, CD36
27	response to wounding	GO:009611	10.0	ADM, POU5F1, CTSB, CASP3, FGF7, FN1
28	transcription initiation from RNA polymerase II promoter	GO:006367	10.0	RXRA, NR6A1, NR2C2, SP1, RARB, RARA
29	positive regulation of phospholipase C activity	GO:010863	9.9	FLT1, FGF2, PDGFRA
30	axon guidance	GO:007411	9.9	GDNF, EPHB2, CSNK2B, COL4A1, CREB1, AP2A1
31	protein processing	GO:016485	9.9	PSEN1, PTHLH, CASP3, MYC, PCSK5
32	cell-cell signaling	GO:007267	9.8	CALCA, PTHLH, WNT2, WNT9B, ADM, ADCYAP1
33	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.8	HOXA7, SUZ12, SP100, NR6A1, RXRA, EGR1
34	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.8	GDNF, POU5F1, TDGF1, TFAP2A, EGR1, RHOQ
35	aging	GO:007568	9.7	ADRB1, ADM, SOCS3, PRKCA, RXRA, CALCA
36	negative regulation of cell proliferation	GO:008285	9.5	FGFR2, IGFBP7, PTHLH, RXRA, TFAP2A, PRKCA
37	nerve growth factor receptor signaling pathway	GO:048011	9.4	ADCYAP1, PRKCA, PRKCG, PSEN1, CREB1, CASP3
38	epidermal growth factor receptor signaling pathway	GO:007173	9.3	PRKCA, PRKCG, TDGF1, TGFA, HBEGF, EGF
39	positive regulation of transcription, DNA-dependent	GO:045893	9.3	DAB2, SP1, SP100, CREB1, EGF, EGR1
40	signal transduction	GO:007165	9.2	HBEGF, ACVR2B, EGF, PLAU, CREB1, TDGF1P3
41	cell adhesion	GO:007155	9.2	EMB, PRKCA, TROAP, IGFBP7, APP, FN1
42	positive regulation of cell proliferation	GO:008284	8.9	ADM, FGF3, FGF2, FGF18, FLT1, ITGB1
43	angiogenesis	GO:001525	8.8	COL4A1, PKNOX1, EGF, TGFA, PRKCA, EPHB2

Molecular functions related to teratocarcinoma according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	retinoic acid receptor activity	GO:003708	10.7	RXRA, RARB, RARA, RARG
2	steroid hormone receptor activity	GO:003707	10.6	RXRA, NR6A1, NR2C2, RARB, RARA, RARG
3	retinoid binding	GO:005501	10.6	RBP1, RBP2, CRABP1, CRABP2
4	retinal binding	GO:016918	10.6	CRABP2, CRABP1, RBP2, RBP1
5	type 2 fibroblast growth factor receptor binding	GO:005111	10.5	FGF18, FGF7, FGF8
6	retinol binding	GO:019841	10.5	CRABP2, CRABP1, RBP2, RBP1
7	heparin binding	GO:008201	10.3	HBEGF, APP, FGFR2, FGF9, FGF7, FGF4
8	sequence-specific DNA binding	GO:043565	10.2	SP1, SUZ12, HOXB5, HOXB1, HOXA7, NR2C2
9	sequence-specific DNA binding transcription factor activity	GO:003700	10.1	HOXB1, HOXA7, HOXA5, HOXA4, HOXA3, HOXB5
10	double-stranded DNA binding	GO:003690	10.1	EGR1, RXRA, CREB1, SP1, ASCL1, JUN
11	protein homodimerization activity	GO:042803	10.0	HPRT1, TERT, SP1, SP100, NR6A1, PDGFRA
12	growth factor activity	GO:008083	10.0	EGF, HBEGF, TGFA, TDGF1, TDGF1P3, NUDT6
13	transcription factor binding	GO:008134	9.9	POU5F1, CSNK2B, SP100, SP1, HOXA7, ENPP2
14	transcription coactivator activity	GO:003713	9.7	SP100, NR2C2, RXRA, TFAP2A, MAX, JUN
15	receptor binding	GO:005102	9.3	CSNK2B, NPY, ADM, ADCYAP1, EPHB2, GDNF
16	protein binding	GO:005515	4.7	ADRB1, CTNNA2, CTSB, NR2C2, SNCA, CREB1