MCID: TRT001
MIFTS: 40

Teratocarcinoma malady

Cancer category

Summaries for Teratocarcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.

MalaCards: Teratocarcinoma, also known as mixed embryonal carcinoma and teratoma, is related to childhood teratocarcinoma of the testis and t-cell leukemia. An important gene associated with Teratocarcinoma is TDGF1 (teratocarcinoma-derived growth factor 1), and among its related pathways is Signaling by NODAL. The compound retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and brain, and related mouse phenotype mortality/aging.

Wikipedia:64 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

Aliases & Classifications for Teratocarcinoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

teratocarcinoma 8 10 45 61
mixed embryonal carcinoma and teratoma 8


External Ids:

Disease Ontology8 DOID:3305
NCIt40 C3756
SNOMED-CT57 67830002
MeSH35 D018243

Related Diseases for Teratocarcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Teratocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1childhood teratocarcinoma of the testis10.2
2t-cell leukemia10.2
3cytomegalovirus infection10.2
4teratoma10.2
5testicular microlithiasis10.1
6germ cell tumors10.1
7embryonal cancer10.0LBX1, CRABP1, HOXA1, LAMB1, TDGF1, TDGF1P3
8systemic lupus erythematosus10.0
9sertoli cell tumor10.0
10meningocele10.0
11infertility10.0
12adenocarcinoma10.0
13adenoma10.0
14t cell deficiency10.0
15testis seminoma10.0
16tuberculosis10.0
17ovarian germ cell tumor10.0
18anal fistula10.0

Graphical network of diseases related to Teratocarcinoma:



Diseases related to teratocarcinoma

Clinical Features for Teratocarcinoma

Drugs & Therapeutics for Teratocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Teratocarcinoma

Drug clinical trials:

Search ClinicalTrials for Teratocarcinoma

Search NIH Clinical Center for Teratocarcinoma

Search CenterWatch for Teratocarcinoma

Genetic Tests for Teratocarcinoma

Anatomical Context for Teratocarcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Teratocarcinoma:

33
Ovary, Liver, Brain, Kidney, Lung, Heart, Colon, Pancreas, Placenta, Testis, T cells, B cells, Cardiac myocytes, Pineal, Pituitary, Testis germ

Animal Models for Teratocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Teratocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076810.9TDGF1, CRABP1, TRO, MAP3K12, BYSL, HOXA1

Publications for Teratocarcinoma

Sources:
51PubMed
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Articles related to Teratocarcinoma:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
Teratocarcinoma in a non seminomatous, mixed germ cell tumour of the testis-a rare entity. (23998086)
2013
2
A teratocarcinoma-like human embryonic stem cell (hESC) line and four hESC lines reveal potentially oncogenic genomic changes. (20428235)
2010
3
Effects of insulin-like growth factor binding protein 7 on apoptosis in human teratocarcinoma cells in vitro. (20393014)
2010
4
Moesin signalling induces F9 teratocarcinoma cells to differentiate into primitive extraembryonic endoderm. (17993262)
2008
5
Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. (17716626)
2007
6
ER stress induces the expression of Jpk, which inhibits cell cycle progression in F9 teratocarcinoma cell. (17404020)
2007
7
The road from teratocarcinoma to human embryonic stem cells. (17142865)
2005
8
A blockade in Wnt signaling is activated following the differentiation of F9 teratocarcinoma cells. (14720502)
2004
9
Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation. (12871956)
2003
10
Paraneoplastic hyperthyroidism in a patient with metastasizing teratocarcinoma and excessively high HCG]. (14579189)
2003
11
Effects of extracellular matrices on F9 teratocarcinoma stem cells: a crucial role of type IV collagen in the early stage of differentiation of F9 stem cells. (12679600)
2002-2003
12
A truncated form of teratocarcinoma-derived growth factor-1 (cripto-1) mRNA expressed in human colon carcinoma cell lines and tumors. (11553858)
2001
13
Differentiation of human pluripotent teratocarcinoma stem cells induced by bone morphogenetic protein-2. (10612460)
1998
14
Expression of teratocarcinoma-derived growth factor-1 (TDGF-1) in testis germ cell tumors and its effects on growth and differentiation of embryonal carcinoma cell line NTERA2/D1. (9285688)
1997
15
The GABAA receptor is expressed in human neurons derived from a teratocarcinoma cell line. (9299433)
1997
16
Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP). (7850777)
1995
17
Induction by adenovirus-5 E1A of the differentiation phenotype of F9 teratocarcinoma cells involves a conserved region (CR1) of E1A. (7742380)
1995
18
Expression of syndecan-1 changes during the differentiation of visceral and parietal endoderm from murine F9 teratocarcinoma cells. (8575644)
1995
19
Globo-series carbohydrate antigens are expressed in different forms on human and murine teratocarcinoma-derived cells. (7960243)
1994
20
Radiation-induced apoptosis in F9 teratocarcinoma cells. (7910198)
1994
21
Formation of the annexin II2p112 complex upon differentiation of F9 teratocarcinoma cells. (8314895)
1993
22
Modulation of fibroblast growth factor receptor expression and signalling during retinoic acid-induced differentiation of Tera-2 teratocarcinoma cells. (7680553)
1993
23
Metastatic mature teratoma in lung following testicular embryonal carcinoma and teratocarcinoma. (8135909)
1993
24
Activation of collagen IV gene expression in F9 teratocarcinoma cells by 3-deazaadenosine analogs. Indirect inhibitors of methylation. (1537874)
1992
25
Retinoic acid regulates gene expression of retinoic acid receptors alpha, beta and gamma in F9 mouse teratocarcinoma cells. (1334013)
1992
26
Effect of ascitic liquid on growth in vitro of embryoid bodies derived from teratocarcinoma. (1576432)
1992
27
Independent regulation of HNF-1 alpha and HNF-1 beta by retinoic acid in F9 teratocarcinoma cells. (2065662)
1991
28
Gene activation mediated by protein kinase C in human macrophage and teratocarcinoma cells expressing aminoglycoside phosphotransferase activity. (1660486)
1991
29
Molecular analysis of APRT deficiency in mouse P19 teratocarcinoma stem cell line. (2011791)
1991
30
Alteration of homeobox gene expression by N-ras transformation of PA- 1 human teratocarcinoma cells. (1675427)
1991
31
Berberine-induced morphologic differentiation and down-regulation of c-Ki-ras2 protooncogene expression in human teratocarcinoma cells. (2265407)
1990
32
Residual proliferative capacity in F9 teratocarcinoma stem cell cultures treated with alpha-difluoromethylornithine, an inducer of parietal endoderm differentiation. (2109649)
1990
33
Milk plasma supports growth and differentiation of a mouse teratocarcinoma cell line. (2732192)
1989
34
Plasminogen activator expression in F9 teratocarcinoma embryoid bodies and their endoderm derivatives. (2516796)
1989
35
A monoclonal antibody, MA21, recognizes a surface component that is present on F9 teratocarcinoma cells and that appears vectorially on the trophectoderm of peri-implantation-stage mouse blastocysts. (2654386)
1989
36
In vivo antitumor effect of methotrexate conjugated to a monoclonal IgM antibody specific for stage-specific embryonic antigen-1, on MH-15 mouse teratocarcinoma. (2567209)
1989
37
Constitutive c-myc expression enhances proliferation of differentiating F9 teratocarcinoma cells. (2475175)
1989
38
Molecular cloning of complementary DNA to mouse tissue plasminogen activator mRNA and its expression during F9 teratocarcinoma cell differentiation. (2826484)
1988
39
Human epithelial teratocarcinoma cells (P3): radiobiological characterization, DNA damage, and comparison with other rodent and human cell lines. (3340734)
1988
40
Teratocarcinoma of the ovary in a mare. (3192478)
1988
41
Interferon inducibility and sensitivity of human teratocarcinoma-derived cell lines. (2440957)
1987
42
The adenovirus Ela gene induces differentiation of F9 teratocarcinoma cells. (2439896)
1987
43
Expression of c-myc during differentiation of the human teratocarcinoma cell line Tera-2. (3327864)
1987
44
Selection against expression of the Escherichia coli gene gpt in hprt+ mouse teratocarcinoma and hybrid cells. (3323888)
1987
45
The outgrowth of parietal endoderm from mouse teratocarcinoma stem-cell embryoid bodies. (2430849)
1986
46
Sialic acid lyase in differentiating murine teratocarcinoma cells. (4065222)
1985
47
Expression of a cytoplasmic LINE-1 transcript is regulated in a human teratocarcinoma cell line. (2412228)
1985
48
A pluripotent human stem-cell clone isolated from the TERA-2 teratocarcinoma line lacks antigens SSEA-3 and SSEA-4 in vitro, but expresses these antigens when grown as a xenograft tumor. (2412924)
1985
49
Gap-junctional communication in a communication-defective and in a communication-competent teratocarcinoma cell line. (3905839)
1985
50
Developmentally regulated surface structures of teratocarcinoma stem cells studied by mutant cell lines. (6535647)
1984

Genetic Variations for Teratocarcinoma

Expression for genes affiliated with Teratocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Teratocarcinoma

Search GEO for disease gene expression data for Teratocarcinoma.

Pathways for genes affiliated with Teratocarcinoma

Sources:
54Reactome
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Pathways related to Teratocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6TDGF1, FST

Compounds for genes affiliated with Teratocarcinoma

Sources:
45Novoseek, 24HMDB
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Compounds related to Teratocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid45 2411.9TDGF1P3, SEPT3, LAMB1, FST, WNT9B, HOXA1

GO Terms for genes affiliated with Teratocarcinoma

Sources:
16Gene Ontology
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Biological processes related to Teratocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:00756610.6LAMB1, TRO
2positive regulation of cell migrationGO:03033510.3TDGF1, LAMB1, RRAS2

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Sources for Teratocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet