MCID: TRT001
MIFTS: 36

Teratocarcinoma malady

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Teratocarcinoma

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Aliases & Descriptions for Teratocarcinoma:

Name: Teratocarcinoma 11 50 39 13 68
 
Mixed Embryonal Carcinoma and Teratoma 11

Classifications:



External Ids:

Disease Ontology11 DOID:3305
MeSH39 D018243
SNOMED-CT62 67830002
NCIt45 C3756

Summaries for Teratocarcinoma

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Disease Ontology:11 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.

MalaCards based summary: Teratocarcinoma, also known as mixed embryonal carcinoma and teratoma, is related to teratoma and childhood teratocarcinoma of the testis. An important gene associated with Teratocarcinoma is TDGF1 (Teratocarcinoma-Derived Growth Factor 1), and among its related pathways are Human Early Embryo Development and Vitamin A and carotenoid metabolism. Affiliated tissues include testis, lung and bone, and related mouse phenotypes are embryo and normal.

Related Diseases for Teratocarcinoma

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Graphical network of the top 20 diseases related to Teratocarcinoma:



Diseases related to teratocarcinoma

Symptoms & Phenotypes for Teratocarcinoma

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MGI Mouse Phenotypes related to Teratocarcinoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.0ENPP2, JUN, LAMB1, NANOG, NR6A1, POU5F1
2MP:00028738.2CRABP1, ENPP2, FGF4, JUN, POU5F1, RARA

Drugs & Therapeutics for Teratocarcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Teratocarcinoma


Cochrane evidence based reviews: teratocarcinoma

Genetic Tests for Teratocarcinoma

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Anatomical Context for Teratocarcinoma

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MalaCards organs/tissues related to Teratocarcinoma:

36
Testis, Lung, Bone, Colon, Brain, Pineal, Cardiac myocytes

Publications for Teratocarcinoma

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Articles related to Teratocarcinoma:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Actions of activin A, connective tissue growth factor, hepatocyte growth factor and teratocarcinoma-derived growth factor 1 on the development of the bovine preimplantation embryo. (27185102)
2016
2
Vitamin D3 stimulates embryonic stem cells but inhibits migration and growth of ovarian cancer and teratocarcinoma cell lines. (27091127)
2016
3
Lysine methylation represses p53 activity in teratocarcinoma cancer cells. (27535933)
2016
4
Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin. (27116544)
2016
5
The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1. (25761220)
2015
6
Pleuritis caused by Acremonium strictum in a patient with metastatic testicular teratocarcinoma. (26042869)
2015
7
Differential expression of HERV-K (HML-2) proviruses in cells and virions of the teratocarcinoma cell line Tera-1. (25746218)
2015
8
Nicotinamide induces apoptosis of F9 mouse teratocarcinoma stem cells by downregulation of SATB1 expression. (25596087)
2015
9
Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/I^-catenin signaling. (25138740)
2014
10
Ligand-independent androgen receptors promote ovarian teratocarcinoma cell growth by stimulating self-renewal of cancer stem/progenitor cells. (24793306)
2014
11
Murine teratocarcinoma-derived neuronal cultures. (23975819)
2013
12
Teratocarcinoma in a non seminomatous, mixed germ cell tumour of the testis-a rare entity. (23998086)
2013
13
MicroRNA-21 promotes the ovarian teratocarcinoma PA1 cell line by sustaining cancer stem/progenitor populations in vitro. (23890123)
2013
14
Development of experimental tumors formed by mouse and human embryonic stem and teratocarcinoma cells after subcutaneous and intraperitoneal transplantations into immunodeficient and immunocompetent mice. (23051679)
2013
15
Extracellular syntaxin4 triggers the differentiation program in teratocarcinoma F9 cells that impacts cell adhesion properties. (23884628)
2013
16
KSRP silencing favors neural differentiation of P19 teratocarcinoma cells. (23462617)
2013
17
MicroRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonic carcinoma P19 cells. (23007514)
2013
18
Wnt/I^-catenin signaling pathway upregulates c-Myc expression to promote cell proliferation of P19 teratocarcinoma cells. (22976998)
2012
19
Presacral teratocarcinoma presenting as anal fistula and rectal adenocarcinoma: a unique case presentation and literature review. (22611366)
2012
20
Primary CNS teratocarcinoma. (22363315)
2012
21
Teratocarcinoma formation in embryonic stem cell-derived neural progenitor hippocampal transplants. (22776287)
2012
22
A spontaneous teratocarcinoma in the testis of a swiss albino mouse. (21270422)
2011
23
Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell. (19943082)
2011
24
Unusual autopsy finding in a case of metastatic teratocarcinoma. (21109467)
2011
25
Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea. (22100652)
2011
26
Teratocarcinoma-derived growth factor 1 (TDGF1) sequence variants in patients with congenital heart defect. (19853938)
2011
27
Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro. (20385969)
2010
28
A teratocarcinoma-like human embryonic stem cell (hESC) line and four hESC lines reveal potentially oncogenic genomic changes. (20428235)
2010
29
Effects of insulin-like growth factor binding protein 7 on apoptosis in human teratocarcinoma cells in vitro. (20393014)
2010
30
Suppression of teratocarcinoma growth by soluble TRAIL gene expression driven by the progression-elevated gene-3 promoter. (19823015)
2009
31
Angiogenesis and vascular network of teratocarcinoma from embryonic stem cell transplant into seminiferous tubules. (19513074)
2009
32
Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells. (18164278)
2008
33
Testicular teratocarcinoma associated with testicular microlithiasis. (17464445)
2008
34
Moesin signalling induces F9 teratocarcinoma cells to differentiate into primitive extraembryonic endoderm. (17993262)
2008
35
Primary mediastinal giant teratocarcinoma. (18626155)
2008
36
Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells. (18237746)
2008
37
Mediastinal teratocarcinoma as initial manifestation of asymptomatic HIV infection: a case report. (18663349)
2008
38
Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke. (18514379)
2008
39
Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. (17716626)
2007
40
ER stress induces the expression of Jpk, which inhibits cell cycle progression in F9 teratocarcinoma cell. (17404020)
2007
41
22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. (17689017)
2007
42
Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements. (17875646)
2007
43
Cervical mature teratoma 17 years after initial treatment of testicular teratocarcinoma: report of a late relapse. (17201931)
2007
44
Identification and partial characterization of soluble and membrane-bound KDN(deaminoneuraminic acid)-glycoproteins in human ovarian teratocarcinoma PA-1, and enhanced expression of free and bound KDN in cells cultured in mannose-rich media. (16897181)
2006
45
Cytotoxicity of a novel fibroblast growth factor receptor targeted immunotoxin on a human ovarian teratocarcinoma cell line. (16999598)
2006
46
Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamma and retinoid-independent pathways. (16788091)
2006
47
Polyunsaturated fatty acids mobilize intracellular Ca2+ in NT2 human teratocarcinoma cells by causing release of Ca2+ from mitochondria. (16601147)
2006
48
Jpk, a novel cell death inducer, regulates the expression of Hoxa7 in F9 teratocarcinoma cells, but not during apoptosis. (17384261)
2006
49
Galpha13 activation rescues moesin-depletion induced apoptosis in F9 teratocarcinoma cells. (16860319)
2006
50
Noxp20 and Noxp70, two new markers of early neuronal differentiation, detected in teratocarcinoma-derived neuroectodermic precursor cells. (17029606)
2006

Variations for Teratocarcinoma

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Expression for genes affiliated with Teratocarcinoma

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Search GEO for disease gene expression data for Teratocarcinoma.

Pathways for genes affiliated with Teratocarcinoma

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GO Terms for genes affiliated with Teratocarcinoma

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Biological processes related to Teratocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1endodermal cell fate specificationGO:000171410.8NANOG, POU5F1
2glandular epithelial cell developmentGO:000206810.7RARA, RARB
3growth plate cartilage developmentGO:000341710.7RARA, RARB
4negative regulation of cartilage developmentGO:006103710.7RARA, RARB
5outflow tract septum morphogenesisGO:000314810.7RARA, RARB
6chondroblast differentiationGO:006059110.7FGF4, RARA
7regulation of myelinationGO:003164110.5RARA, RARB
8retinoic acid receptor signaling pathwayGO:004838410.5RARA, RARB
9cellular processGO:000998710.2JUN, RRAS2
10negative regulation of apoptotic processGO:004306610.1FGF4, JUN, RARA, RARB, TDGF1
11positive regulation of cell proliferationGO:000828410.0FGF4, JUN, RARA, RARB, TDGF1
12ventricular cardiac muscle cell differentiationGO:005501210.0RARA, RARB
13somatic stem cell population maintenanceGO:00350199.9NANOG, POU5F1, TDGF1
14positive regulation of transcription from RNA polymerase II promoterGO:00459449.3FGF4, JUN, NANOG, NR6A1, POU5F1, RARA

Molecular functions related to Teratocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1retinoic acid receptor activityGO:000370810.7RARA, RARB
2retinoic acid bindingGO:000197210.6CRABP1, RARA
3steroid hormone receptor activityGO:00037079.7NR6A1, RARA, RARB
4sequence-specific DNA bindingGO:00435659.5JUN, NANOG, NR6A1, POU5F1, RARA, RARB

Sources for Teratocarcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet