MCID: TRT010
MIFTS: 53

Teratoma malady

Summaries for Teratoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A teratoma is an encapsulated tumor with tissue or organ components resembling normal derivatives of... more...

MalaCards: Teratoma is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Teratoma is AFP (alpha-fetoprotein), and among its related pathways are Cardiac Progenitor Differentiation and Selected targets of Oct-3/4. The compounds vegf and progesterone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are behavior/neurological and reproductive system.

Aliases & Classifications for Teratoma

Sources:
10DISEASES, 45Novoseek, 61UMLS
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Aliases & Descriptions:

teratoma 10 45 61


Related Diseases for Teratoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the malignant teratoma family:

intermediate malignant teratoma adult teratoma
teratoma with malignant transformation teratoma

Diseases related to Teratoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 416)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.0CGB7, CGB, NKX2-1, MUC16, KRT7, ACTC1
2adenocarcinoma30.9CGB5, CGB7, CGB, NKX2-1, AFP, MUC16
3germ cell tumors30.6KIT
4germinoma30.5KIT, POU5F1, AFP, CGB, CGB5, CGA
5struma ovarii30.4NKX2-1, MUC16
6testicular cancer30.3AFP, CGB, CGB5, CGA
7papillary carcinoma30.2NKX2-1, MUC16, KRT7, ACTC1
8mucinous cystadenocarcinoma30.2MUC16, KRT7
9dysgerminoma30.2CGA, CGB5, AFP, POU5F1, KIT, KRT7
10ectopic pregnancy30.2CGA, CGB5, CGB7, CGB
11germ cell cancer30.2CGA, AFP
12neuroendocrine carcinoma30.2KRT7, KIT, NKX2-1
13angiosarcoma30.2ACTC1
14adenoma30.1CGA, CGB7, CGB, NKX2-1, KRT7, ACTC1
15cystadenoma30.1KRT7
16wilms tumor30.0ACTC1, KRT7, NKX2-1
17thyroid cancer30.0TP53, NKX2-1
18bronchogenic cyst30.0MUC16
19thyroiditis29.9CGA
20placental site trophoblastic tumor29.9CGA, CGB5, CGB
21paraganglioma29.9GFAP, KIT
22male germ cell tumor, somatic29.9CGA, AFP
23large cell carcinoma29.9CGB5, NKX2-1, KRT7
24ependymoma29.9GFAP
25bladder carcinoma29.9CGB7, CGB, PTGS2, TP53
26hyperprolactinemia29.6CGA, CGB5, CGB
27sertoli-leydig cell tumor29.6KRT7, AFP
28omphalocele29.6AFP
29gonadoblastoma29.6KIT, POU5F1
30ganglioneuroma29.6GFAP
31ulcerative colitis29.6TP53
32sacrococcygeal teratoma11.1
33ovarian cystic teratoma10.8
34growing teratoma syndrome10.7
35adult teratoma10.7
36nasopharyngeal teratoma10.7
37mediastinum teratoma10.5
38epignathus10.5
39gliomatosis peritonei10.5
40malignant ovarian cyst10.5
41fallopian tube teratoma10.4
42n syndrome10.4
43nonseminomatous germ cell tumor10.4
44mixed germ cell tumor10.4
45klinefelter's syndrome10.4
46adult cystic teratoma10.3
47ovarian squamous cell carcinoma10.3
48malignant germ cell tumor10.3
49limbic encephalitis10.3
50pseudomyxoma peritonei10.3

Graphical network of the top 20 diseases related to Teratoma:



Diseases related to teratoma

Clinical Features for Teratoma

Drugs & Therapeutics for Teratoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Teratoma

Drug clinical trials:

Search ClinicalTrials for Teratoma

Search NIH Clinical Center for Teratoma

Search CenterWatch for Teratoma

Genetic Tests for Teratoma

Anatomical Context for Teratoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Teratoma:

33
Bone marrow, Whole blood, Lymph node, Spleen, Thymus, Brain, Cerebellum, Spinal cord, Heart, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Ovary, Uterus, Placenta, Prostate, Testis, Cervix, Myeloid, T cells, B cells, Fetal brain, Medulla oblongata, Tongue, Fetal liver, Fetal lung, Bronchial epithelium, Appendix, Fetal thyroid, Pineal, Pituitary, Uterus corpus, Testis germ, Testis leydig

Animal Models for Teratoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Teratoma

Sources:
51PubMed
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Articles related to Teratoma:

(show top 50)    (show all 2060)
idTitleAuthorsYear
1
Early Prenatal Detection of an Intra-abdominal Cryptorchid Testicular Teratoma. (24054441)
2014
2
111In-pentetreotide uptake in an ovarian teratoma and impact of SPECT/CT imaging. (23989444)
2013
3
KRAS mutation positive mucinous adenocarcinoma originating in mature ovarian teratoma: Case report and review of literature. (24422958)
2013
4
Simultaneous combined single stage removal of immature teratoma at anterior skull base: a case report. (22502784)
2012
5
High-grade sarcoma masquerading as growing teratoma syndrome after resection of ovarian immature teratoma: report of a case. (22498946)
2012
6
Recurrence of mature cystic teratoma at a site of incision. (22779980)
2012
7
Intramedullary lumbosacral teratoma in a domestic ferret (Mustela putorius furo). (22529139)
2012
8
Teratoma of the mediastinum: a case report. (21599893)
2011
9
Relationship between endometriosis, endometrioid adenocarcinoma, gliomatosis peritonei, and carcinoid tumor in a patient with recurrent ovarian teratoma. (21293285)
2011
10
Images for surgeons. A case of matured mediastinal teratoma complicated by cardiac tamponade: an unusual aetiology. (21061752)
2010
11
Inadvertent rupture of benign cystic teratoma does not impair future fertility. (20739009)
2010
12
Mature cystic teratoma: Unusual presentation as dysphagia. (20108063)
2009
13
Successful pregnancy after treatment for ovarian malignant teratoma with growing teratoma syndrome. (19152879)
2009
14
Mature cystic teratoma in the posterior mediastinum. (19503655)
2009
15
Sacrococcygeal teratoma: Excision aided by laparocopic ligation of the median sacral artery in a premature neonate. (20177446)
2009
16
Adenocarcinoma arising in anterior mediastinal mature cystic teratoma: report of a case. (18368326)
2008
17
Metachronous mature teratoma in the corpus callosum occurring 12 years after a pineal germinoma. (18590442)
2008
18
Bifocal mixed germ-cell tumor with growing teratoma syndrome and metachronous mature metastases: case report. (18574668)
2008
19
Prenatal sonographic diagnosis of an oropharyngeal teratoma (epignathus) on a stillborn infant: a case report. (17729204)
2007
20
Malignant transformation of intracranial mature teratoma to yolk sac tumor after late relapse. Case report. (17564180)
2007
21
Neurogenic bladder dysfunction after sacrococcygeal teratoma resection. (16406929)
2006
22
Monolateral mature ovarian cystic teratoma. (15746800)
2005
23
Spontaneous rupture of mediastinal cystic teratoma with high levels of amylase, lipase, CA 19-9, CA 125 and CEA in cystic fluid: a case report. (15164790)
2004
24
Mediastinal growing teratoma syndrome after cisplatin-based chemotherapy and radiotherapy for intracranial germinoma. (14752454)
2004
25
Abnormal umbilical cord Doppler sonograms may predict impending demise in fetuses with sacrococcygeal teratoma. A report of two cases. (14646415)
2004
26
Preoperative diagnosis of malignant transformation arising from mature cystic teratoma of the ovary. (12893196)
2003
27
Application of comparative genomic hybridization technique for detection of chromosomal aberrations in benign cystic teratoma. (12810260)
2003
28
Stroma adjacent to metastatic mature teratoma after chemotherapy for testicular germ cell tumors is derived from the same progenitor cells as the teratoma. (14522936)
2003
29
Liver transplantation for growing teratoma syndrome: report of a case. (14586885)
2003
30
Two cases of unusual urethral complications after resection of sacrococcygeal teratoma. (14614737)
2003
31
Sacrococcygeal teratoma: 25 year experience. (11336088)
2001
32
Prenatally diagnosed sacrococcygeal teratoma: a unique expression of trisomy 1q. (10700874)
2000
33
CT features of torsion of benign cystic teratoma of the ovary. (10589567)
1999
34
Sacrococcygeal teratoma with vascular placental dissemination. (10912432)
1999
35
Cystic teratoma of the greater omentum: a case report and review of the literature. (9311177)
1997
36
Serous cystadenocarcinoma and ovarian teratoma during pregnancy. (8737305)
1996
37
Yolk sac tumor identified at autopsy after surgical excision of immature sacrococcygeal teratoma. (7666328)
1995
38
Paget's disease and invasive undifferentiated carcinoma occurring in a mature cystic teratoma of the ovary. (1653182)
1991
39
Nasopharyngeal teratoma ('hairy polyp'), Dandy-Walker malformation, diaphragmatic hernia, and other anomalies in a female infant. (2074566)
1990
40
Embryonal rhabdomyosarcoma arising in a mature teratoma of the testis: a case report. (2188021)
1990
41
The use of serum TA-4 in monitoring patients with malignant transformation of ovarian mature cystic teratoma. (2736493)
1989
42
Squamous cell carcinoma arising in mature cystic teratoma of the ovary. Clinicopathologic and topographic analysis. (2712191)
1989
43
Sacrococcygeal teratoma. (4038215)
1985
44
Serum tumour marker regression rate following chemotherapy for malignant teratoma. (6209145)
1984
45
Pregnancy specific beta 1 glycoprotein: a comparison of analysis by radioimmunoassay and enzyme linked immunosorbent assay observations on patients with malignant teratoma of testis. (6974761)
1981
46
Primary intracranial mixed choriocarcinoma and malignant teratoma. (96120)
1978
47
NASOPHARYNGEAL TERATOMA. (14310179)
1965
48
ADULT NASOPHARYNGEAL TERATOMA IN THE NEWBORN. (14239539)
1964
49
Acute Epididymo-orchitis and Teratoma of Testis. (20789394)
1962
50
Roentgen therapy for malignant teratoma of the testis. (20990621)
1946

Genetic Variations for Teratoma

Expression for genes affiliated with Teratoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Teratoma

Search GEO for disease gene expression data for Teratoma.

Pathways for genes affiliated with Teratoma

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 52QIAGEN
See all sources

Pathways related to Teratoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5SOX2, POU5F1, KIT, ACTC1
210.5TP53, POU5F1, CGB, CGB7, SOX2
310.5TP53, AFP, CGA
4
Hide members
10.5CGB, CGA
510.5POU5F1, SOX2

Compounds for genes affiliated with Teratoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1vegf4511.0TP53, CGA, CGB5, PTGS2, ACTC1, KRT7
2progesterone45 60 29 11 2415.0NKX2-1, CGB, CGB7, CGB5, CGA, AFP
3retinoic acid45 2412.0SOX2, CGB5, CGB7, NKX2-1, AFP, POU5F1
4paraffin4511.0ACTC1, KRT7, GFAP, KIT, CD99, MUC16
5testosterone45 60 11 2414.0CGA, CGB5, CGB7, CGB, AFP, MUC16
6cisplatin45 50 60 1114.0CGA, CGB5, CGB7, CGB, AFP, MUC16
7oestriol4511.0CGA, CGB5, CGB7, CGB, AFP
8bleomycin45 1111.9CGA, CGB5, CGB7, CGB, AFP, TP53
9methotrexate45 50 1112.9CGA, CGB5, CGB7, CGB, AFP, KIT
10lactate4510.9CGA, CGB5, CGB7, CGB, AFP, MUC16
11hematoxylin4510.9NKX2-1, MUC16, KIT, GFAP, KRT7, ACTC1
12b 7234510.9NKX2-1, AFP, MUC16, KRT7, ACTC1
13cyclophosphamide45 50 1112.9CGA, CGB5, CGB, AFP, MUC16, TP53
14estrogen4510.9GFAP
15etoposide45 50 60 1113.9CGB5, CGB7, CGB, AFP
16estradiol45 11 2412.9CGA, CGB5, CGB7, CGB, AFP, MUC16
17creatinine4510.9CGA, CGB5, CGB, AFP, MUC16, GFAP
18clomiphene citrate4510.9CGA, CGB5, CGB, AFP
19mifepristone45 60 29 1113.9CGA, CGB5, CGB, AFP, PTGS2
20ctp4510.9CGB, CGB7, CGB5, CGA
21ifosfamide45 1111.9AFP, CGB, CGB5, CGA
22vincristine45 50 1112.9KIT, AFP
23formaldehyde45 2411.9NKX2-1, KIT, GFAP, KRT7, ACTC1
24doxorubicin45 50 1112.9CGA, CGB5, AFP, MUC16, KIT, TP53
25glycogen45 2411.9CGB5, AFP, KIT, GFAP, KRT7, ACTC1
26paclitaxel45 50 1112.9CGB5, AFP, MUC16, GFAP, TP53
27actinomycin d4510.9CGA, CGB5, AFP, KIT, PTGS2, TP53
28steroid4510.9CGA, CGB5, NKX2-1, AFP, MUC16, KIT
29glucose4510.9CGB5, CGB, MUC16, GFAP, KRT7, ACTC1
30vinblastine45 50 1112.8TP53, AFP, CGB5, CGA
318-bromo-cyclic amp4510.8CGA, CGB5, GFAP
32dexamethasone45 50 29 1113.8CGB5, NKX2-1, AFP, MUC16, GFAP, PTGS2
33reticulin4510.8GFAP, KRT7, ACTC1
34iron45 2411.8AFP, MUC16, GFAP, KRT7, ACTC1, PTGS2
35gnrh4510.8CGA, CGB5, CGB7, CGB, NKX2-1
36irinotecan45 50 1112.8AFP, KIT, PTGS2, TP53
37mucicarmine4510.8ACTC1, KRT7, NKX2-1
38carboplatin45 50 1112.8CGA, AFP, MUC16, TP53
39ribonucleic acid4510.8CGA, CGB5, NKX2-1, KIT, ACTC1
40tyrosine4510.8SCYL1, CGB5, NKX2-1, AFP, MUC16, KIT
41cyclic amp45 2411.7MRGPRD, CGA, CGB5, CGB, NKX2-1, GFAP
4211-ketotestosterone4510.7CGB5, CGA
43cycloheximide4510.7CGB5
44(+-)-pgf2-alpha4510.6CGA, CGB5, PTGS2
4517-hydroxyprogesterone45 2411.6MUC16, CGB5, CGA
46sialic acid4510.6KRT7, CGA
47thyroxine45 2411.5CGA, CGB7, CGB, AFP
48diethylstilbestrol45 29 1112.5AFP, CGB5, CGA
49methanol45 2411.4ACTC1, KRT7, GFAP
50serine4510.2CGA, CGB5, NKX2-1, AFP, MUC16, KIT

GO Terms for genes affiliated with Teratoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.5TP53, SCYL1, DDIT4L, AFP, POU5F1, CD99

Biological processes related to Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endodermal cell fate specificationGO:00171410.5POU5F1, SOX2
2detection of mechanical stimulus involved in sensory perception of soundGO:05091010.5KIT, SOX2
3response to woundingGO:00961110.4GFAP, POU5F1, SOX2
4epithelial tube branching involved in lung morphogenesisGO:06044110.2NKX2-1, SOX2

Molecular functions related to Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1miRNA bindingGO:03519810.5POU5F1, SOX2
2transcription regulatory region DNA bindingGO:04421210.2TP53, POU5F1, NKX2-1, SOX2

Products for genes affiliated with Teratoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Teratoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet