MCID: TRT010
MIFTS: 55

Teratoma malady

Cancer diseases category
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Summaries for Teratoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 A teratoma is an encapsulated tumor with tissue or organ components resembling normal derivatives of... more...

MalaCards: Teratoma is related to germ cell tumors and adenocarcinoma. An important gene associated with Teratoma is AFP (alpha-fetoprotein), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Ovarian steroidogenesis. The compounds ctp and oestriol have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and thyroid, and related mouse phenotypes are tumorigenesis and skeleton.

Aliases & Classifications for Teratoma

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10DISEASES, 45Novoseek, 62UMLS
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Classifications:

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Global: Cancer diseases


Aliases & Descriptions:

teratoma 10 45 62


Related Diseases for Teratoma

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17GeneCards, 18GeneDecks
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Diseases in the Malignant Teratoma family:

Intermediate Malignant Teratoma Adult Teratoma
teratoma

Diseases related to Teratoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 375)
idRelated DiseaseScoreTop Affiliating Genes
1germ cell tumors31.1KIT
2adenocarcinoma30.9PTGS2, ACTC1, AFP, NKX2-1, CGB
3endodermal sinus tumor30.7AFP, CGB
4klinefelter's syndrome30.6CGA, CGB
5choriocarcinoma30.5CGA, CGB, AFP
6melanoma30.5CGB, KIT, ACTC1, NKX2-1
7germinoma30.4CGA, POU5F1, CGB, KIT, AFP
8testicular cancer30.3CGA, AFP, CGB
9sarcoma30.3CGB, KIT, ACTC1
10germ cell cancer30.3AFP, CGA
11ectopic pregnancy30.3CGB, CGA
12neuroendocrine carcinoma30.2NKX2-1, KIT
13leydig cell tumor30.2CGA
14seminoma30.2CGA, CGB, KIT, POU5F1, AFP, SOX2
15endometriosis30.2PTGS2, CGA, ACTC1
16dysgerminoma30.2CGA, KIT, POU5F1, AFP
17hemangioma30.2ACTC1, NKX2-1
18adenoma30.1CGA, ACTC1, PTGS2, NKX2-1, CGB
19male germ cell tumor, somatic30.1AFP, CGA
20placental site trophoblastic tumor30.0CGA, CGB
21down syndrome30.0AFP, CGA, CGB
22omphalocele29.9AFP
23oligohydramnios29.9AFP
24paraganglioma29.9GFAP, KIT
25hyperprolactinemia29.8CGA, CGB
26neural tube defects29.8CGA, CGB, AFP
27gonadoblastoma29.7POU5F1, KIT
28neurofibroma29.7ACTC1, KIT
29cystic teratoma11.1
30sacrococcygeal teratoma11.1
31mature teratoma11.0
32malignant teratoma10.9
33gastric teratoma10.8
34mediastinitis10.8
35growing teratoma syndrome10.8
36nasopharyngeal teratoma10.7
37nasopharyngitis10.7
38ovarian cystic teratoma10.7
39thyroiditis10.6
40teratoma with malignant transformation10.6
41gliomatosis peritonei10.5
42epignathus10.5
43encephalitis10.5
44cervicitis10.4
45peritonitis10.4
46nonseminomatous germ cell tumor10.4
47adult teratoma10.3
48mixed germ cell tumor10.3
49limbic encephalitis10.3
50cleft palate10.3

Graphical network of the top 20 diseases related to Teratoma:



Diseases related to teratoma

Symptoms for Teratoma

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Drugs & Therapeutics for Teratoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Teratoma

Search NIH Clinical Center for Teratoma

Genetic Tests for Teratoma

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Anatomical Context for Teratoma

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33MalaCards
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MalaCards organs/tissues related to Teratoma:

33
Ovary, Testis, Thyroid, Bone, Eye, Pineal, Liver, Pancreas, Lung, Colon, Heart, Pituitary, Kidney, Uterus, Tongue, Prostate, Spinal cord, Breast, Brain, Appendix, Testes, Adrenal gland, Lymph node, Cervix, Thymus, Small intestine, Skin, Myeloid, Cerebellum, Spleen, Bone marrow, Salivary gland, Placenta, Medulla oblongata

Animal Models for Teratoma or affiliated genes

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37MGI
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Publications for Teratoma

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52PubMed
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Articles related to Teratoma:

(show top 50)    (show all 2021)
idTitleAuthorsYear
1
Heterogenous malignant presacral teratoma with a locally destructive benign intrasacral component. (24178949)
2013
2
Embryonal rhabdomyosarcoma arising from a mediastinal teratoma: an unusual case report. (23487585)
2013
3
The long-term psychosocial outcomes following excision of sacrococcygeal teratoma: a national study. (24277662)
2013
4
Intrapericardial mature cystic teratoma in an adult: case presentation. (23007804)
2013
5
Profound nephrotic syndrome in a patient with ovarian teratoma. (23816730)
2013
6
Primary lymphoma arising in a mature cystic teratoma of the ovary. (23163645)
2012
7
Mature posterior fossa teratoma mimicking infratentorial meningioma: a case report. (22030172)
2012
8
Chemical meningitis caused by spontaneous rupture of spinal teratoma. (22799119)
2012
9
A case report of nasopharyngeal teratoma with a cleft palate and an inguinal hernia. (21524948)
2011
10
Mediastinal epithelioid hemangioendothelioma mimicking a teratoma. (21492982)
2011
11
Prostate tissue within teratoma component of malignant mixed germ cell tumor. (20667927)
2010
12
Images for surgeons. A case of matured mediastinal teratoma complicated by cardiac tamponade: an unusual aetiology. (21061752)
2010
13
Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans. (20967026)
2010
14
Primary adenocarcinoid tumor of the ovary arising in mature cystic teratoma. A case report. (19317273)
2009
15
Malignant transformation of mature cystic teratoma of the ovary: experience at a single institution. (18823690)
2008
16
A case of spermatic cord teratoma in low-stage testicular cancer managed by surveillance. (18268549)
2008
17
Sacrococcygeal teratoma in an adult female Nigerian. (19253526)
2008
18
Immature teratoma of gallbladder associated with gliomatosis peritonei, a case report. (17923185)
2007
19
Primitive neuroectodermal tumor arising in a testicular teratoma with retroperitoneal metastasis: report of an interesting case with review of literature. (17991577)
2007
20
Interstitial cells of Cajal (ICC) in mature cystic teratoma of the ovary. (16405675)
2006
21
Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25). (15917269)
2005
22
Retrorectal benign cystic teratoma misdiagnosed with high lying pararectal abscess. (15244193)
2003
23
Pulmonary mature teratoma. Primary? Or metastatic? (14735060)
2003
24
An adolescent with ovarian osteosarcoma arising in a cystic teratoma. (12759630)
2003
25
Large, complex, benign cystic teratoma in an adolescent. (12002202)
2002
26
Case 52: gastric teratoma. (12409586)
2002
27
Dramatic response of teratoma-associated non--germ-cell cancer with all-trans retinoic acid in a patient with nonseminomatous germ cell tumor. (11407397)
2001
28
Management of malignant pineal germ cell tumors with residual mature teratoma. (11865805)
2001
29
Sacrococcygeal teratoma: 25 year experience. (11336088)
2001
30
Immunohistochemical detection of parathyroid hormone-related protein in a squamous cell carcinoma arising from mature cystic teratoma causing humoral hypercalcemia of malignancy. (11104629)
2000
31
Successful fetal sacrococcygeal teratoma resection in a hydropic fetus. (11051157)
2000
32
Metachronous neurohypophyseal germinoma occurring 8 years after total resection of pineal mature teratoma. (9457272)
1998
33
Cystic teratoma of the greater omentum: a case report and review of the literature. (9311177)
1997
34
Retroperitoneal teratoma as first sign of Klinefelter's syndrome. (7702385)
1995
35
CA19-9 in mature cystic teratoma. (8073424)
1994
36
Lower urinary tract dysfunction in children with benign sacrococcygeal teratoma. (8254808)
1994
37
Anorectal function in adults operated for a benign sacrococcygeal teratoma. (8308684)
1993
38
Sacrococcygeal teratoma and venous shunting through a tumor: biological evidence. (1734786)
1992
39
Coexistence of mature teratoma and thecoma in an ovary. A report of two cases. (1664641)
1991
40
HCG producing malignant teratoma of the testis: a rare cause of precocious isosexual maturation in boys]. (1706819)
1990
41
Neonatal sacrococcygeal teratoma: multiimaging modality assessment. (2193140)
1990
42
Prolonged survival in a patient with disseminated malignant teratoma in the presence of a persistently elevated serum alpha-fetoprotein level. (2464429)
1989
43
Prenatal sonographic diagnosis of congenital sacrococcygeal teratoma and management. (2681670)
1989
44
Giant sacrococcygeal teratoma in an African child. (3829022)
1986
45
Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses A clinicopathologic study of 20 cases. (6322958)
1984
46
Malignant teratoma--with emphasis on the yolk sac tumor component. (6202823)
1984
47
Microsurgery of teratoma and germinoma involving the diencephalon and the brain stem. (6657078)
1983
48
Letter to the editor: Adult teratoma of the testis metastasizing as adult teratoma: case report and review of literature. (1255903)
1976
49
Squamous cell carcinoma in situ arising in adult cystic teratoma of the ovary. (5009017)
1972
50
Sacrococcygeal teratoma. (13533715)
1958

Variations for Teratoma

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Expression for genes affiliated with Teratoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Teratoma

Search GEO for disease gene expression data for Teratoma.

Pathways for genes affiliated with Teratoma

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50PathCards, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 5Cell Signaling Technology, 55Reactome, 60Thomson Reuters, 12EMD Millipore
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Pathways related to Teratoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7AFP, NKX2-1
29.7CGA, PTGS2
39.6SOX2, POU5F1
49.6POU5F1, SOX2
59.6POU5F1, SOX2
69.3POU5F1, SOX2, AFP
7
Show member pathways
9.3CGA, POU5F1, PTGS2
89.3CGB, POU5F1, SOX2
98.9GFAP, PTGS2, NKX2-1
108.4KIT, ACTC1, POU5F1, SOX2
11
Show member pathways
8.0KIT, SOX2, PTGS2, GFAP

Compounds for genes affiliated with Teratoma

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45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1ctp4510.1CGA, CGB
2oestriol4510.0CGA, CGB, AFP
3clomiphene citrate4510.0CGA, CGB, AFP
4mafp4510.0PTGS2, AFP
5ifosfamide45 1111.0CGA, CGB, AFP
6bleomycin45 1110.9AFP, CGB, CGA
7mucicarmine459.9ACTC1, NKX2-1
8thyroxine45 2410.9AFP, CGB, CGA
9s 100459.8GFAP, ACTC1
10clodronate45 51 1111.8CGA, PTGS2
118-bromo-cyclic amp459.8CGA, GFAP
12cyclophosphamide45 51 1111.8CGA, CGB, AFP
13b 723459.8AFP, ACTC1, NKX2-1
14(+-)-pgf2-alpha459.8CGA, PTGS2
15reticulin459.8GFAP, ACTC1
16gnrh459.5NKX2-1, CGB, CGA
17mifepristone45 29 61 1112.5AFP, PTGS2, CGB, CGA
18etoposide45 51 61 1112.5AFP, PTGS2, CGB, CGA
19vincristine45 51 1111.4CGB, KIT, AFP
20estradiol45 24 1111.3CGA, CGB, AFP, GFAP
21matrigel459.3CGB, ACTC1, GFAP
22irinotecan45 51 1111.2AFP, PTGS2, KIT
23methotrexate51 45 1111.2AFP, KIT, CGB, CGA
24cyclic amp45 2410.1GFAP, NKX2-1, CGB, CGA
25iron45 2410.1ACTC1, PTGS2, AFP, GFAP
26creatinine459.0CGA, CGB, ACTC1, AFP, GFAP
27ribonucleic acid459.0CGA, KIT, NKX2-1, ACTC1
28alanine458.9GFAP, AFP, MNX1, CGB, CGA
29actinomycin d458.9CGA, KIT, PTGS2, AFP
30cisplatin45 51 61 1111.8GFAP, AFP, PTGS2, CGB, CGA
31glycogen45 249.8KIT, ACTC1, AFP, GFAP
32aspartate458.8GFAP, AFP, KIT, CGA
33oxygen45 249.7GFAP, AFP, PTGS2, POU5F1, ACTC1
34hematoxylin458.7GFAP, ACTC1, NKX2-1, KIT
35steroid458.7AFP, ACTC1, NKX2-1, KIT, CGA
36formaldehyde45 249.7GFAP, ACTC1, NKX2-1, KIT
37dexamethasone45 51 29 1111.6GFAP, AFP, PTGS2, ACTC1, NKX2-1
38lactate458.6GFAP, AFP, KIT, CGB, CGA
39cycloheximide458.5CGA, KIT, PTGS2, GFAP
40zinc45 249.5GFAP, AFP, SOX2, NKX2-1
41glucose458.4GFAP, AFP, ACTC1, KIT, CGB
42testosterone45 61 24 1111.2GFAP, AFP, ACTC1, KIT, CGB, CGA
43paraffin458.1GFAP, AFP, ACTC1, NKX2-1, KIT, CGA
44threonine458.0GFAP, AFP, NKX2-1, KIT
45serine458.0GFAP, AFP, NKX2-1, KIT, CGA
46tyrosine457.9KIT, NKX2-1, ACTC1, AFP, GFAP
47progesterone45 29 61 24 1111.8GFAP, AFP, ACTC1, NKX2-1, KIT, CGB
48vegf457.3CGA, GFAP, AFP, PTGS2, POU5F1, ACTC1
49estrogen457.3GFAP, AFP, PTGS2, ACTC1, NKX2-1, KIT
50retinoic acid45 248.1GFAP, AFP, MNX1, SOX2, POU5F1, ACTC1

GO Terms for genes affiliated with Teratoma

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16Gene Ontology
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Cellular components related to Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.1NKX2-1, POU5F1, SOX2

Biological processes related to Teratoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:01648610.0CGA, CGB
2thyroid gland developmentGO:0308789.9NKX2-1, CGA
3endodermal cell fate specificationGO:0017149.8SOX2, POU5F1
4epithelial tube branching involved in lung morphogenesisGO:0604419.7NKX2-1, SOX2
5pituitary gland developmentGO:0219839.6NKX2-1, SOX2
6forebrain developmentGO:0309009.4NKX2-1, SOX2
7detection of mechanical stimulus involved in sensory perception of soundGO:0509109.3KIT, SOX2
8regulation of gene expressionGO:0104689.3POU5F1, SOX2
9positive regulation of Notch signaling pathwayGO:0457479.2KIT, SOX2
10response to woundingGO:0096119.2POU5F1, SOX2, GFAP
11positive regulation of MAPK cascadeGO:0434109.1KIT, SOX2
12somatic stem cell maintenanceGO:0350199.0KIT, POU5F1, SOX2
13positive regulation of transcription from RNA polymerase II promoterGO:0459448.8SOX2, POU5F1, NKX2-1, CGA

Molecular functions related to Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1miRNA bindingGO:0351989.6POU5F1, SOX2
2transcription regulatory region DNA bindingGO:0442128.8SOX2, POU5F1, NKX2-1
3sequence-specific DNA binding transcription factor activityGO:0037008.7NKX2-1, POU5F1, SOX2, MNX1
4sequence-specific DNA bindingGO:0435658.6NKX2-1, POU5F1, SOX2, MNX1

Products for genes affiliated with Teratoma

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Sources for Teratoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet