MCID: TRT010
MIFTS: 59

Teratoma malady

Cancer diseases, Rare diseases categories
Download this MalaCard

Summaries for Teratoma

About this section


Fully expand this MalaCard
Wikipedia:65 A teratoma is a tumor with tissue or organ components resembling normal derivatives of more than one... more...

MalaCards based summary: Teratoma is related to germ cell tumors and endodermal sinus tumor. An important gene associated with Teratoma is AFP (alpha-fetoprotein), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Ovarian steroidogenesis. The compounds ctp and oestriol have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and thyroid, and related mouse phenotypes are tumorigenesis and skeleton.

Aliases & Classifications for Teratoma

About this section
Sources:
10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Related Diseases for Teratoma

About this section

Diseases in the Malignant Teratoma family:

Intermediate Malignant Teratoma Adult Teratoma
teratoma

Diseases related to Teratoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 380)
idRelated DiseaseScoreTop Affiliating Genes
1germ cell tumors31.4KIT
2endodermal sinus tumor31.2AFP, CGB
3klinefelter's syndrome31.0CGB, CGA
4choriocarcinoma30.8CGA, CGB, AFP
5male germ cell tumor, somatic30.8AFP, CGA
6germ cell cancer30.8AFP, CGA
7adenocarcinoma30.7CGB, NKX2-1, ACTC1, PTGS2, AFP
8leydig cell tumor30.7CGA
9ectopic pregnancy30.7CGB, CGA
10testicular cancer30.6CGA, CGB, AFP
11anencephaly30.5AFP, CGA
12placental site trophoblastic tumor30.5CGB, CGA
13omphalocele30.5AFP
14oligohydramnios30.5AFP
15endometriosis30.4CGA, ACTC1, PTGS2
16down syndrome30.3CGA, CGB, AFP
17neuroendocrine carcinoma30.3KIT, NKX2-1
18sarcoma30.2CGB, KIT, ACTC1
19hyperprolactinemia30.2CGB, CGA
20germinoma30.2AFP, POU5F1, KIT, CGB, CGA
21melanoma30.1ACTC1, NKX2-1, KIT, CGB
22hemangioma30.1ACTC1, NKX2-1
23neural tube defects30.1CGA, CGB, AFP
24dysgerminoma30.1AFP, POU5F1, KIT, CGA
25adenoma29.9PTGS2, ACTC1, NKX2-1, CGB, CGA
26gonadoblastoma29.9KIT, POU5F1
27neurofibroma29.8KIT, ACTC1
28paraganglioma29.8KIT, GFAP
29seminoma29.7AFP, SOX2, POU5F1, KIT, CGB, CGA
30cystic teratoma11.2
31sacrococcygeal teratoma11.1
32mature teratoma11.0
33malignant teratoma10.9
34gastric teratoma10.8
35growing teratoma syndrome10.8
36mediastinitis10.8
37ovarian cystic teratoma10.7
38nasopharyngeal teratoma10.7
39nasopharyngitis10.7
40thyroiditis10.6
41teratoma with malignant transformation10.6
42epignathus10.6
43gliomatosis peritonei10.6
44extragonadal germ cell tumor10.5AFP
45encephalitis10.5
46adenosarcoma10.5ACTC1
47cervicitis10.5
48pulmonary blastoma10.5NKX2-1
49edwards syndrome10.4CGA, AFP
50peritonitis10.4

Graphical network of the top 20 diseases related to Teratoma:



Diseases related to teratoma

Symptoms for Teratoma

About this section

Drugs & Therapeutics for Teratoma

About this section

Drug clinical trials:

Search ClinicalTrials for Teratoma

Search NIH Clinical Center for Teratoma

Genetic Tests for Teratoma

About this section

Anatomical Context for Teratoma

About this section

MalaCards organs/tissues related to Teratoma:

32
Ovary, Testis, Thyroid, Bone, Eye, Pineal, Liver, Pancreas, Lung, Heart, Colon, Pituitary, Kidney, Uterus, Tongue, Spinal cord, Prostate, Brain, Breast, Lymph node, Adrenal gland, Skin, Testes, Appendix, Thymus, Cerebellum, Small intestine, Cervix, Spleen, Myeloid, Bone marrow, Salivary gland, Placenta, Medulla oblongata

Animal Models for Teratoma or affiliated genes

About this section

Publications for Teratoma

About this section

Articles related to Teratoma:

(show top 50)    (show all 2101)
idTitleAuthorsYear
1
Growing teratoma syndrome: clinical and radiographic characteristics. (24750260)
2014
2
Ovarian Growing Teratoma Syndrome With Spuriously Elevated I+-Fetoprotein. (24711556)
2014
3
Chemoresponsive liver hemangioma in a patient with metastatic malignant teratoma. (25168798)
2014
4
Immature uterine teratoma associated with uterine inversion. (25276328)
2014
5
Management of central nervous system teratoma. (25150764)
2014
6
Heterogenous malignant presacral teratoma with a locally destructive benign intrasacral component. (24178949)
2013
7
Embryonal rhabdomyosarcoma arising from a mediastinal teratoma: an unusual case report. (23487585)
2013
8
The long-term psychosocial outcomes following excision of sacrococcygeal teratoma: a national study. (24277662)
2013
9
Intrapericardial mature cystic teratoma in an adult: case presentation. (23007804)
2013
10
Primary lymphoma arising in a mature cystic teratoma of the ovary. (23163645)
2012
11
Mature posterior fossa teratoma mimicking infratentorial meningioma: a case report. (22030172)
2012
12
Chemical meningitis caused by spontaneous rupture of spinal teratoma. (22799119)
2012
13
A case report of nasopharyngeal teratoma with a cleft palate and an inguinal hernia. (21524948)
2011
14
Mediastinal epithelioid hemangioendothelioma mimicking a teratoma. (21492982)
2011
15
Prostate tissue within teratoma component of malignant mixed germ cell tumor. (20667927)
2010
16
Images for surgeons. A case of matured mediastinal teratoma complicated by cardiac tamponade: an unusual aetiology. (21061752)
2010
17
Primary adenocarcinoid tumor of the ovary arising in mature cystic teratoma. A case report. (19317273)
2009
18
Malignant transformation of mature cystic teratoma of the ovary: experience at a single institution. (18823690)
2008
19
A case of spermatic cord teratoma in low-stage testicular cancer managed by surveillance. (18268549)
2008
20
Sacrococcygeal teratoma in an adult female Nigerian. (19253526)
2008
21
Immature teratoma of gallbladder associated with gliomatosis peritonei, a case report. (17923185)
2007
22
Primitive neuroectodermal tumor arising in a testicular teratoma with retroperitoneal metastasis: report of an interesting case with review of literature. (17991577)
2007
23
Interstitial cells of Cajal (ICC) in mature cystic teratoma of the ovary. (16405675)
2006
24
Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25). (15917269)
2005
25
Retrorectal benign cystic teratoma misdiagnosed with high lying pararectal abscess. (15244193)
2003
26
Pulmonary mature teratoma. Primary? Or metastatic? (14735060)
2003
27
An adolescent with ovarian osteosarcoma arising in a cystic teratoma. (12759630)
2003
28
Large, complex, benign cystic teratoma in an adolescent. (12002202)
2002
29
Case 52: gastric teratoma. (12409586)
2002
30
Dramatic response of teratoma-associated non--germ-cell cancer with all-trans retinoic acid in a patient with nonseminomatous germ cell tumor. (11407397)
2001
31
Management of malignant pineal germ cell tumors with residual mature teratoma. (11865805)
2001
32
Sacrococcygeal teratoma: 25 year experience. (11336088)
2001
33
Immunohistochemical detection of parathyroid hormone-related protein in a squamous cell carcinoma arising from mature cystic teratoma causing humoral hypercalcemia of malignancy. (11104629)
2000
34
Successful fetal sacrococcygeal teratoma resection in a hydropic fetus. (11051157)
2000
35
Metachronous neurohypophyseal germinoma occurring 8 years after total resection of pineal mature teratoma. (9457272)
1998
36
Cystic teratoma of the greater omentum: a case report and review of the literature. (9311177)
1997
37
CA19-9 in mature cystic teratoma. (8073424)
1994
38
Anorectal function in adults operated for a benign sacrococcygeal teratoma. (8308684)
1993
39
Sacrococcygeal teratoma and venous shunting through a tumor: biological evidence. (1734786)
1992
40
Coexistence of mature teratoma and thecoma in an ovary. A report of two cases. (1664641)
1991
41
HCG producing malignant teratoma of the testis: a rare cause of precocious isosexual maturation in boys]. (1706819)
1990
42
Neonatal sacrococcygeal teratoma: multiimaging modality assessment. (2193140)
1990
43
Prolonged survival in a patient with disseminated malignant teratoma in the presence of a persistently elevated serum alpha-fetoprotein level. (2464429)
1989
44
Prenatal sonographic diagnosis of congenital sacrococcygeal teratoma and management. (2681670)
1989
45
Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses A clinicopathologic study of 20 cases. (6322958)
1984
46
Malignant teratoma--with emphasis on the yolk sac tumor component. (6202823)
1984
47
Letter to the editor: Adult teratoma of the testis metastasizing as adult teratoma: case report and review of literature. (1255903)
1976
48
Squamous cell carcinoma in situ arising in adult cystic teratoma of the ovary. (5009017)
1972
49
Sacrococcygeal teratoma. (13533715)
1958
50
Sacrococcygeal teratoma including case report. (13040721)
1953

Variations for Teratoma

About this section

Expression for genes affiliated with Teratoma

About this section
Expression patterns in normal tissues for genes affiliated with Teratoma

Search GEO for disease gene expression data for Teratoma.

Pathways for genes affiliated with Teratoma

About this section

Pathways related to Teratoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7AFP, NKX2-1
29.7CGA, PTGS2
39.6SOX2, POU5F1
49.6POU5F1, SOX2
59.6POU5F1, SOX2
69.3POU5F1, SOX2, AFP
7
Show member pathways
9.3CGA, POU5F1, PTGS2
89.3CGB, POU5F1, SOX2
98.9GFAP, PTGS2, NKX2-1
108.4KIT, ACTC1, POU5F1, SOX2
11
Show member pathways
8.0KIT, SOX2, PTGS2, GFAP

Compounds for genes affiliated with Teratoma

About this section

Compounds related to Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1ctp4410.1CGA, CGB
2oestriol4410.0CGA, CGB, AFP
3clomiphene citrate4410.0CGA, CGB, AFP
4mafp4410.0PTGS2, AFP
5ifosfamide44 1111.0CGA, CGB, AFP
6bleomycin44 1110.9AFP, CGB, CGA
7mucicarmine449.9ACTC1, NKX2-1
8thyroxine44 2410.9AFP, CGB, CGA
9s 100449.8GFAP, ACTC1
10clodronate44 50 1111.8CGA, PTGS2
118-bromo-cyclic amp449.8CGA, GFAP
12cyclophosphamide44 50 1111.8CGA, CGB, AFP
13b 723449.8AFP, ACTC1, NKX2-1
14(+-)-pgf2-alpha449.8CGA, PTGS2
15reticulin449.8GFAP, ACTC1
16gnrh449.5NKX2-1, CGB, CGA
17mifepristone44 28 61 1112.5AFP, PTGS2, CGB, CGA
18etoposide44 50 61 1112.5AFP, PTGS2, CGB, CGA
19vincristine44 50 1111.4CGB, KIT, AFP
20estradiol44 24 1111.3CGA, CGB, AFP, GFAP
21matrigel449.3CGB, ACTC1, GFAP
22irinotecan44 50 1111.2AFP, PTGS2, KIT
23methotrexate50 44 1111.2AFP, KIT, CGB, CGA
24cyclic amp44 2410.1GFAP, NKX2-1, CGB, CGA
25iron44 2410.1ACTC1, PTGS2, AFP, GFAP
26creatinine449.0CGA, CGB, ACTC1, AFP, GFAP
27ribonucleic acid449.0CGA, KIT, NKX2-1, ACTC1
28alanine448.9GFAP, AFP, MNX1, CGB, CGA
29actinomycin d448.9CGA, KIT, PTGS2, AFP
30cisplatin44 50 61 1111.8GFAP, AFP, PTGS2, CGB, CGA
31glycogen44 249.8KIT, ACTC1, AFP, GFAP
32aspartate448.8GFAP, AFP, KIT, CGA
33oxygen44 249.7GFAP, AFP, PTGS2, POU5F1, ACTC1
34hematoxylin448.7GFAP, ACTC1, NKX2-1, KIT
35steroid448.7AFP, ACTC1, NKX2-1, KIT, CGA
36formaldehyde44 249.7GFAP, ACTC1, NKX2-1, KIT
37dexamethasone44 50 28 1111.6GFAP, AFP, PTGS2, ACTC1, NKX2-1
38lactate448.6GFAP, AFP, KIT, CGB, CGA
39cycloheximide448.5CGA, KIT, PTGS2, GFAP
40zinc44 249.5GFAP, AFP, SOX2, NKX2-1
41glucose448.4GFAP, AFP, ACTC1, KIT, CGB
42testosterone44 61 24 1111.2GFAP, AFP, ACTC1, KIT, CGB, CGA
43paraffin448.1GFAP, AFP, ACTC1, NKX2-1, KIT, CGA
44threonine448.0GFAP, AFP, NKX2-1, KIT
45serine448.0GFAP, AFP, NKX2-1, KIT, CGA
46tyrosine447.9KIT, NKX2-1, ACTC1, AFP, GFAP
47progesterone44 28 61 24 1111.8GFAP, AFP, ACTC1, NKX2-1, KIT, CGB
48vegf447.3CGA, GFAP, AFP, PTGS2, POU5F1, ACTC1
49estrogen447.3GFAP, AFP, PTGS2, ACTC1, NKX2-1, KIT
50retinoic acid44 248.1GFAP, AFP, MNX1, SOX2, POU5F1, ACTC1

GO Terms for genes affiliated with Teratoma

About this section

Cellular components related to Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.1NKX2-1, POU5F1, SOX2

Biological processes related to Teratoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:01648610.0CGA, CGB
2thyroid gland developmentGO:0308789.9NKX2-1, CGA
3endodermal cell fate specificationGO:0017149.8SOX2, POU5F1
4epithelial tube branching involved in lung morphogenesisGO:0604419.7NKX2-1, SOX2
5pituitary gland developmentGO:0219839.6NKX2-1, SOX2
6forebrain developmentGO:0309009.4NKX2-1, SOX2
7detection of mechanical stimulus involved in sensory perception of soundGO:0509109.3KIT, SOX2
8regulation of gene expressionGO:0104689.3POU5F1, SOX2
9positive regulation of Notch signaling pathwayGO:0457479.2KIT, SOX2
10response to woundingGO:0096119.2POU5F1, SOX2, GFAP
11positive regulation of MAPK cascadeGO:0434109.1KIT, SOX2
12somatic stem cell maintenanceGO:0350199.0KIT, POU5F1, SOX2
13positive regulation of transcription from RNA polymerase II promoterGO:0459448.8SOX2, POU5F1, NKX2-1, CGA

Molecular functions related to Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1miRNA bindingGO:0351989.6POU5F1, SOX2
2transcription regulatory region DNA bindingGO:0442128.8SOX2, POU5F1, NKX2-1
3sequence-specific DNA binding transcription factor activityGO:0037008.7NKX2-1, POU5F1, SOX2, MNX1
4sequence-specific DNA bindingGO:0435658.6NKX2-1, POU5F1, SOX2, MNX1

Products for genes affiliated with Teratoma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Teratoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet