MCID: TRT010
MIFTS: 37

Teratoma malady

Summaries for Teratoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A teratoma is an encapsulated tumor with tissue or organ components resembling normal derivatives of... more...

MalaCards: Teratoma is related to mature teratoma and squamous cell carcinoma. An important gene associated with Teratoma is AFP (alpha-fetoprotein), and among its related pathways are Cardiac Progenitor Differentiation and Selected targets of Oct-3/4. The compounds vegf and progesterone have been mentioned in the context of this disorder. Affiliated tissues include eye and bone, and related mouse phenotypes are behavior/neurological and reproductive system.

Aliases & Classifications for Teratoma

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10DISEASES, 44Novoseek, 60UMLS
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Aliases & Descriptions:

teratoma 10 44 60


Related Diseases for Teratoma

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17GeneCards, 18GeneDecks
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Diseases in the Malignant Teratoma family:

Intermediate Malignant Teratoma Adult Teratoma
teratoma

Diseases related to Teratoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 431)
idRelated DiseaseScoreTop Affiliating Genes
1mature teratoma31.7DDIT4L
2squamous cell carcinoma30.9CGB7, CGB, NKX2-1, MUC16, KRT7, ACTC1
3adenocarcinoma30.9CGB5, CGB7, CGB, NKX2-1, AFP, MUC16
4thyroiditis30.8CGA
5melanoma30.5CGB, NKX2-1, KIT, ACTC1, TP53
6peritonitis30.5MUC16
7endodermal sinus tumor30.5AFP
8choriocarcinoma30.3CGA, CGB5, CGB7, CGB, AFP
9struma ovarii30.3NKX2-1, MUC16
10seminoma30.3SOX2, CGA, CGB5, CGB7, CGB, AFP
11cystadenocarcinoma30.3MUC16
12sarcoma30.2CGB5, CGB, CD99, KIT, ACTC1, TP53
13testicular cancer30.2AFP, CGB, CGB5, CGA
14oligodendroglioma30.2GFAP, TP53
15ovarian cyst30.2CGA, CGB5, MUC16
16papillary carcinoma30.2NKX2-1, MUC16, KRT7, ACTC1
17rhabdomyosarcoma30.2TP53, ACTC1, CD99
18mucinous cystadenocarcinoma30.2MUC16, KRT7
19leukemia30.1CGB, MNX1, CD99, KIT, TP53
20neuroendocrine carcinoma30.1KRT7, KIT, NKX2-1
21ovarian cancer30.1NKX2-1, MUC16, KRT7, PTGS2, TP53
22ovarian disease30.1CGA, MUC16
23angiosarcoma30.1ACTC1
24adenoma30.0CGA, CGB7, CGB, NKX2-1, KRT7, ACTC1
25endometriosis30.0CGA, MUC16, ACTC1, PTGS2
26nephroblastoma30.0TP53
27cystadenoma30.0KRT7
28meningioma30.0GFAP
29hemangioma30.0ACTC1, NKX2-1
30leydig cell tumor29.9CGA, CGB5
31leiomyoma29.9ACTC1, KIT
32colon adenocarcinoma29.9PTGS2
33breast cancer29.9CGB, NKX2-1, MUC16, KRT7, ACTC1, TP53
34thyroid cancer29.9TP53, NKX2-1
35down syndrome29.8CGA, CGB5, CGB7, CGB, AFP
36placental site trophoblastic tumor29.8CGA, CGB5, CGB
37paraganglioma29.8GFAP, KIT
38osteosarcoma29.8CGB, TP53
39hepatocellular carcinoma29.8NKX2-1, AFP, KRT7, PTGS2, TP53
40papilloma29.8ACTC1, TP53
41male germ cell tumor, somatic29.8CGA, AFP
42chordoma29.8KRT7, GFAP
43large cell carcinoma29.8CGB5, NKX2-1, KRT7
44dermatomyositis29.8MUC16
45bladder carcinoma29.8CGB7, CGB, PTGS2, TP53
46fibrosarcoma29.8ACTC1
47pituitary adenoma29.6CGA, CGB7, POU5F1
48hepatitis29.6CD99, AFP
49hyperprolactinemia29.6CGA, CGB5, CGB
50medulloblastoma29.6TP53, ACTC1, GFAP

Graphical network of the top 20 diseases related to Teratoma:



Diseases related to teratoma

Clinical Features for Teratoma

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Drugs & Therapeutics for Teratoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Teratoma

Drug clinical trials:

Search ClinicalTrials for Teratoma

Search NIH Clinical Center for Teratoma

Search CenterWatch for Teratoma

Genetic Tests for Teratoma

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Anatomical Context for Teratoma

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32MalaCards
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MalaCards organs/tissues related to Teratoma:

32
Eye, Bone

Animal Models for Teratoma or affiliated genes

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36MGI
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Publications for Teratoma

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Genetic Variations for Teratoma

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Expression for genes affiliated with Teratoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Teratoma

Search GEO for disease gene expression data for Teratoma.

Pathways for genes affiliated with Teratoma

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37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 51QIAGEN
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Pathways related to Teratoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5SOX2, POU5F1, KIT, ACTC1
210.5TP53, POU5F1, CGB, CGB7, SOX2
310.5TP53, AFP, CGA
4
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10.5CGB, CGA
510.5POU5F1, SOX2

Compounds for genes affiliated with Teratoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1vegf4411.0TP53, CGA, CGB5, PTGS2, ACTC1, KRT7
2progesterone44 59 28 11 2415.0NKX2-1, CGB, CGB7, CGB5, CGA, AFP
3retinoic acid44 2412.0SOX2, CGB5, CGB7, NKX2-1, AFP, POU5F1
4paraffin4411.0ACTC1, KRT7, GFAP, KIT, CD99, MUC16
5testosterone44 59 11 2414.0CGA, CGB5, CGB7, CGB, AFP, MUC16
6cisplatin44 49 59 1114.0CGA, CGB5, CGB7, CGB, AFP, MUC16
7oestriol4411.0CGA, CGB5, CGB7, CGB, AFP
8bleomycin44 1111.9CGA, CGB5, CGB7, CGB, AFP, TP53
9methotrexate44 49 1112.9CGA, CGB5, CGB7, CGB, AFP, KIT
10lactate4410.9CGA, CGB5, CGB7, CGB, AFP, MUC16
11hematoxylin4410.9NKX2-1, MUC16, KIT, GFAP, KRT7, ACTC1
12b 7234410.9NKX2-1, AFP, MUC16, KRT7, ACTC1
13cyclophosphamide44 49 1112.9CGA, CGB5, CGB, AFP, MUC16, TP53
14estrogen4410.9GFAP
15etoposide44 49 59 1113.9CGB5, CGB7, CGB, AFP
16estradiol44 11 2412.9CGA, CGB5, CGB7, CGB, AFP, MUC16
17creatinine4410.9CGA, CGB5, CGB, AFP, MUC16, GFAP
18clomiphene citrate4410.9CGA, CGB5, CGB, AFP
19mifepristone44 59 28 1113.9CGA, CGB5, CGB, AFP, PTGS2
20ctp4410.9CGB, CGB7, CGB5, CGA
21ifosfamide44 1111.9AFP, CGB, CGB5, CGA
22vincristine44 49 1112.9KIT, AFP
23formaldehyde44 2411.9NKX2-1, KIT, GFAP, KRT7, ACTC1
24doxorubicin44 49 1112.9CGA, CGB5, AFP, MUC16, KIT, TP53
25glycogen44 2411.9CGB5, AFP, KIT, GFAP, KRT7, ACTC1
26paclitaxel44 49 1112.9CGB5, AFP, MUC16, GFAP, TP53
27actinomycin d4410.9CGA, CGB5, AFP, KIT, PTGS2, TP53
28steroid4410.9CGA, CGB5, NKX2-1, AFP, MUC16, KIT
29glucose4410.9CGB5, CGB, MUC16, GFAP, KRT7, ACTC1
30vinblastine44 49 1112.8TP53, AFP, CGB5, CGA
318-bromo-cyclic amp4410.8CGA, CGB5, GFAP
32dexamethasone44 49 28 1113.8CGB5, NKX2-1, AFP, MUC16, GFAP, PTGS2
33reticulin4410.8GFAP, KRT7, ACTC1
34iron44 2411.8AFP, MUC16, GFAP, KRT7, ACTC1, PTGS2
35gnrh4410.8CGA, CGB5, CGB7, CGB, NKX2-1
36irinotecan44 49 1112.8AFP, KIT, PTGS2, TP53
37mucicarmine4410.8ACTC1, KRT7, NKX2-1
38carboplatin44 49 1112.8CGA, AFP, MUC16, TP53
39ribonucleic acid4410.8CGA, CGB5, NKX2-1, KIT, ACTC1
40tyrosine4410.8SCYL1, CGB5, NKX2-1, AFP, MUC16, KIT
41cyclic amp44 2411.7MRGPRD, CGA, CGB5, CGB, NKX2-1, GFAP
4211-ketotestosterone4410.7CGB5, CGA
43cycloheximide4410.7CGB5
44(+-)-pgf2-alpha4410.6CGA, CGB5, PTGS2
4517-hydroxyprogesterone44 2411.6MUC16, CGB5, CGA
46sialic acid4410.6KRT7, CGA
47thyroxine44 2411.5CGA, CGB7, CGB, AFP
48diethylstilbestrol44 28 1112.5AFP, CGB5, CGA
49methanol44 2411.4ACTC1, KRT7, GFAP
50serine4410.2CGA, CGB5, NKX2-1, AFP, MUC16, KIT

GO Terms for genes affiliated with Teratoma

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16Gene Ontology
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Cellular components related to Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.5TP53, SCYL1, DDIT4L, AFP, POU5F1, CD99

Biological processes related to Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endodermal cell fate specificationGO:00171410.5POU5F1, SOX2
2detection of mechanical stimulus involved in sensory perception of soundGO:05091010.5KIT, SOX2
3response to woundingGO:00961110.4GFAP, POU5F1, SOX2
4epithelial tube branching involved in lung morphogenesisGO:06044110.2NKX2-1, SOX2

Molecular functions related to Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1miRNA bindingGO:03519810.5POU5F1, SOX2
2transcription regulatory region DNA bindingGO:04421210.2TP53, POU5F1, NKX2-1, SOX2

Products for genes affiliated with Teratoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Teratoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet