MCID: TRT005
MIFTS: 17

Teratoma with Malignant Transformation

Categories: Rare diseases

Aliases & Classifications for Teratoma with Malignant Transformation

MalaCards integrated aliases for Teratoma with Malignant Transformation:

Name: Teratoma with Malignant Transformation 49

Classifications:



Summaries for Teratoma with Malignant Transformation

NIH Rare Diseases : 49 A teratoma with malignant transformation (TMT) is a tumor that develops from germ cells when they grow and divide abnormally, forming a mass.  Approximately 6% of teratomas develop into TMTs by a process called malignant transformation, when some of the cells in the teratoma become cancerous.  TMTs can occur anywhere in the body, but most are located in the testes in men or ovaries in women.  The cause of TMT is unknown.  Treatment may include surgery and chemotherapy. Last updated: 9/21/2012

MalaCards based summary : Teratoma with Malignant Transformation is related to teratoma and cystic teratoma. The drugs nivolumab and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include testes, ovary and neutrophil.

Related Diseases for Teratoma with Malignant Transformation

Diseases related to Teratoma with Malignant Transformation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 teratoma 10.5
2 cystic teratoma 10.2
3 adenocarcinoma 10.0
4 mediastinitis 10.0
5 mature teratoma 10.0
6 germ cells tumors 9.9
7 squamous cell carcinoma 9.9
8 sacrococcygeal teratoma 9.7
9 mucinous adenocarcinoma 9.7
10 cerebritis 9.7
11 ovarian germ cell teratoma 9.7
12 mediastinum teratoma 9.7

Graphical network of the top 20 diseases related to Teratoma with Malignant Transformation:



Diseases related to Teratoma with Malignant Transformation

Symptoms & Phenotypes for Teratoma with Malignant Transformation

Drugs & Therapeutics for Teratoma with Malignant Transformation

Drugs for Teratoma with Malignant Transformation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antibodies, Monoclonal Phase 2
3 Immunoglobulins Phase 2
4 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2

Search NIH Clinical Center for Teratoma with Malignant Transformation

Genetic Tests for Teratoma with Malignant Transformation

Anatomical Context for Teratoma with Malignant Transformation

MalaCards organs/tissues related to Teratoma with Malignant Transformation:

38
Testes, Ovary, Neutrophil

Publications for Teratoma with Malignant Transformation

Articles related to Teratoma with Malignant Transformation:

(show all 32)
# Title Authors Year
1
Elevated preoperative neutrophil : lymphocyte ratio as a preoperative indicator of mature cystic teratoma with malignant transformation. ( 28370831 )
2017
2
The Case of an Elderly Male Patient with Unknown Primary Mucinous Adenocarcinoma within Presacral Teratoma (Teratoma with Malignant Transformation). ( 25874143 )
2015
3
Teratoma with malignant transformation: report of three cases and review of the literature. ( 24908364 )
2014
4
Naturally occurring mediastinal teratoma with malignant transformation in an adult male. ( 24003416 )
2013
5
Re: towards the definition of the best management and prognostic factors of teratoma with malignant transformation: a single-institution case series and new proposal. ( 22494724 )
2012
6
Squamous cell carcinoma occurring in the pelvis after total hysterectomy and bilateral salpingo-oophorectomy for an ovarian mature teratoma with malignant transformation. ( 23040935 )
2012
7
Towards the definition of the best management and prognostic factors of teratoma with malignant transformation: a single-institution case series and new proposal. ( 20868391 )
2011
8
Teratoma with malignant transformation: a case report with pathological, cytogenetic, and immunohistochemistry analysis. ( 21776193 )
2011
9
Mature cystic teratoma with malignant transformation to adenocarcinoma. ( 21619995 )
2011
10
CT findings of mature cystic teratoma with malignant transformation: comparison with mature cystic teratoma. ( 21724123 )
2011
11
Non-germ cell tumours arising in germ cell tumours (teratoma with malignant transformation) in men: CT and MR findings. ( 19056194 )
2009
12
Teratoma with malignant transformation in the anterior mediastinum. ( 18603085 )
2008
13
An unusual case of giant mediastinal teratoma with malignant transformation. ( 18573447 )
2008
14
Chemotherapy in patients with teratoma with malignant transformation. ( 17081678 )
2007
15
Eyelid metastasis from mediastinal teratoma with malignant transformation. ( 17851848 )
2007
16
Preoperative diagnosis of mature cystic teratoma with malignant transformation: analysis of imaging findings and clinical and laboratory data. ( 16924513 )
2007
17
Use of the collagen gel droplet embedded drug sensitivity test to determine drug sensitivity against ovarian mature cystic teratoma with malignant transformation to adenocarcinoma: a case report. ( 17308380 )
2007
18
Cerebral mature teratoma with malignant transformation in a 52-year-old man: a case report. ( 16637568 )
2006
19
Poor prognosis of intraoperative rupture of mature cystic teratoma with malignant transformation. ( 17175475 )
2006
20
Teratoma with malignant transformation: experiences of the cooperative GPOH protocols MAKEI 83/86/89/96. ( 17080331 )
2006
21
Chemotherapy for teratoma with malignant transformation. ( 14645417 )
2003
22
Intraperitoneal cancer spread after laparoscopic cystectomy for mature teratoma with malignant transformation. ( 12013109 )
2002
23
Ovarian teratoma with malignant transformation: CT diagnosis. ( 12034646 )
2002
24
Case report: sacrococcygeal teratoma with malignant transformation in an adult female: CT and MRI findings. ( 12145137 )
2002
25
Expression of cyclooxygenase-2 in ovarian mature cystic teratomas with malignant transformation. ( 11605016 )
2001
26
A ruptured teratoma with malignant transformation. ( 10939511 )
2000
27
Teratoma with malignant transformation in the anterior mediastinum: a case report. ( 11752948 )
2000
28
Teratoma with malignant transformation: diverse malignant histologies arising in men with germ cell tumors. ( 9400455 )
1998
29
Ovarian mature cystic teratoma with malignant transformation. An interphase cytogenetic study. ( 9785136 )
1998
30
Testicular teratoma with malignant transformation, presenting as squamous cell carcinoma with metastatic localization in the penile corpus cavernosum. ( 9043522 )
1997
31
Well-differentiated adenocarcinoma arising from mature cystic teratoma of the mediastinum (teratoma with malignant transformation). Report of a surgical case. ( 8160647 )
1994
32
Teratoma with malignant transformation in germ cell tumors in men. ( 2990657 )
1985

Variations for Teratoma with Malignant Transformation

Expression for Teratoma with Malignant Transformation

Search GEO for disease gene expression data for Teratoma with Malignant Transformation.

Pathways for Teratoma with Malignant Transformation

GO Terms for Teratoma with Malignant Transformation

Sources for Teratoma with Malignant Transformation

3 CDC
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11 DGIdb
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58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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