MCID: TRT002
MIFTS: 29

Tertiary Neurosyphilis

Categories: Neuronal diseases, Infectious diseases

Aliases & Classifications for Tertiary Neurosyphilis

MalaCards integrated aliases for Tertiary Neurosyphilis:

Name: Tertiary Neurosyphilis 12 14
Late Syphilis of Central Nervous System Nos 69
Late Neurosyphilis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9988
ICD10 32 A52.3
ICD9CM 34 094 094.9
MeSH 41 D009494
NCIt 46 C84935

Summaries for Tertiary Neurosyphilis

Disease Ontology : 12 A tertiary syphilis that results_in infection located in brain or located in spinal cord.

MalaCards based summary : Tertiary Neurosyphilis, also known as late syphilis of central nervous system nos, is related to meningovascular neurosyphilis and parenchymatous neurosyphilis. An important gene associated with Tertiary Neurosyphilis is EXTL3 (Exostosin Like Glycosyltransferase 3). Affiliated tissues include brain or, brain and spinal cord, and related phenotypes are cellular and hematopoietic system

Related Diseases for Tertiary Neurosyphilis

Diseases related to Tertiary Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 meningovascular neurosyphilis 32.0 CD40LG CD79A MBP
2 parenchymatous neurosyphilis 31.7 EXTL3 FLYWCH1 MBP
3 asymptomatic neurosyphilis 29.2 CD40LG CD79A CXCL10 CXCL13 DDX41 EXTL3
4 tabes dorsalis 29.2 CD79A DDX41 EXTL3 FXN KCNA5 LEFTY2
5 late congenital syphilis 10.6 DDX41 EXTL3
6 syphilitic meningitis 10.6 CD40LG EXTL3
7 optic papillitis 10.6 CD40LG EXTL3
8 cardiovascular syphilis 10.6 CD40LG DDX41
9 focal chorioretinitis 10.6 CD40LG DDX41
10 selective igg deficiency disease 10.6 CD40LG CD79A
11 c1q nephropathy 10.5 CD40LG CD79A
12 alpha chain disease 10.5 CD40LG CD79A
13 brill-zinsser disease 10.5 CD40LG CD79A
14 exudative glomerulonephritis 10.5 CD40LG CD79A
15 cork-handlers' disease 10.5 CD40LG CD79A
16 salpingo-oophoritis 10.5 CD40LG CD79A
17 ventilation pneumonitis 10.5 CD40LG CD79A
18 chronic interstitial cystitis 10.5 CD40LG CD79A
19 axillary adenitis 10.5 CD40LG CD79A
20 cryofibrinogenemia 10.5 CD40LG CD79A
21 trichostrongyloidiasis 10.5 CD40LG CD79A
22 subacute bacterial endocarditis 10.5 CD40LG CD79A
23 heterophyiasis 10.5 CD40LG CD79A
24 immunoglobulin g deficiency 10.5 CD40LG CD79A
25 orbital granuloma 10.5 CD40LG CD79A
26 early congenital syphilis 10.5 CD40LG MYH9
27 transient hypogammaglobulinemia of infancy 10.5 CD40LG CD79A
28 hyperglobulinemic purpura 10.5 CD40LG CD79A
29 gastroduodenitis 10.5 CD40LG CD79A
30 bacterial conjunctivitis 10.5 CD40LG CD79A
31 pontiac fever 10.5 CD40LG TRIM37
32 heavy chain disease 10.5 CD40LG CD79A
33 ophthalmia neonatorum 10.5 CD40LG CD79A
34 immunoglobulin a deficiency 1 10.5 CD40LG CD79A
35 parotid disease 10.5 CD40LG CD79A
36 cerebral arteritis 10.5 CD40LG CD79A
37 selective immunoglobulin deficiency disease 10.5 CD40LG CD79A
38 geniculate herpes zoster 10.5 CD40LG CD79A
39 erythema elevatum diutinum 10.4 CD40LG CD79A
40 sporotrichosis 10.4 CD40LG CD79A
41 fallopian tube disease 10.4 CD40LG CD79A
42 early yaws 10.4 CD40LG CD79A EXTL3
43 chorioretinitis 10.4 CD40LG CD79A EXTL3
44 hyperimmunoglobulin syndrome 10.4 CD40LG CD79A
45 urethritis 10.4 CD40LG CD79A EXTL3
46 polyclonal hypergammaglobulinemia 10.4 CD40LG CD79A
47 endocardium disease 10.4 CD40LG CD79A SH3BP5
48 monoclonal paraproteinemia 10.4 CD40LG CD79A
49 salpingitis 10.4 CD40LG CD79A
50 ocular toxoplasmosis 10.4 CD40LG CD79A

Graphical network of the top 20 diseases related to Tertiary Neurosyphilis:



Diseases related to Tertiary Neurosyphilis

Symptoms & Phenotypes for Tertiary Neurosyphilis

MGI Mouse Phenotypes related to Tertiary Neurosyphilis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.13 TRIM37 ITPA CD40LG KCNA5 CD79A CXCL10
2 hematopoietic system MP:0005397 10 TRIM37 ITPA CD40LG KCNA5 LEFTY2 CD79A
3 immune system MP:0005387 9.9 CD40LG KCNA5 CD79A LEFTY2 CXCL10 MBP
4 mortality/aging MP:0010768 9.77 GRM1 ITPA CD40LG LEFTY2 CXCL10 MBP
5 nervous system MP:0003631 9.36 SPTLC1 GRM1 CD40LG KCNA5 CD79A LEFTY2

Drugs & Therapeutics for Tertiary Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Tertiary Neurosyphilis

Genetic Tests for Tertiary Neurosyphilis

Anatomical Context for Tertiary Neurosyphilis

The Foundational Model of Anatomy Ontology organs/tissues related to Tertiary Neurosyphilis:

18
Brain Or

MalaCards organs/tissues related to Tertiary Neurosyphilis:

38
Brain, Spinal Cord, Bone

Publications for Tertiary Neurosyphilis

Articles related to Tertiary Neurosyphilis:

# Title Authors Year
1
Neurocognitive changes in tertiary neurosyphilis: a retrospective chart review. ( 24878469 )
2014
2
A case of tertiary neurosyphilis presenting with moth-eaten bone lesions. ( 24552413 )
2013
3
Meningovascular form of neuroborreliosis: similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. ( 2251916 )
1990

Variations for Tertiary Neurosyphilis

Expression for Tertiary Neurosyphilis

Search GEO for disease gene expression data for Tertiary Neurosyphilis.

Pathways for Tertiary Neurosyphilis

GO Terms for Tertiary Neurosyphilis

Molecular functions related to Tertiary Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CD40LG CXCL10 CXCL13 LEFTY2
2 CXCR3 chemokine receptor binding GO:0048248 8.62 CXCL10 CXCL13

Sources for Tertiary Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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