MCID: TST014
MIFTS: 62

Testicular Cancer malady

Rare diseases, Cancer diseases, Reproductive diseases categories
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Summaries for Testicular Cancer

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MedlinePlus:33 Testicles, or testes, make male hormones and sperm. they are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. you can get cancer in one or both testicles. testicular cancer mainly affects young men between the ages of 20 and 39. it is also more common in men who have had abnormal testicle development have had an undescended testicle have a family history of the cancer symptoms include pain, swelling, or lumps in your testicles or groin area. doctors use a physical exam, lab tests, imaging tests, and a biopsy to diagnose testicular cancer. most cases can be treated, especially if found early. treatment options include surgery, radiation, and/or chemotherapy. regular exams after treatment are important. treatments may also cause infertility. if you may want children later on, you should consider sperm banking before treatment. nih: national cancer institute

MalaCards based summary: Testicular Cancer, also known as cancer of the testes, is related to germ cell cancer and male germ cell tumor, somatic. An important gene associated with Testicular Cancer is AFP (alpha-fetoprotein), and among its related pathways is Peptide hormone metabolism. The drugs chlorambucil and cisplatin and the compounds 11-ketotestosterone and organon have been mentioned in the context of this disorder. Affiliated tissues include the testicles, testis and testes.

Disease Ontology:8 A male reproductive system cancer that is located in the testicles.

Wikipedia:65 Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system. more...

Description from OMIM:46 273300

Aliases & Classifications for Testicular Cancer

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Testicular Cancer, Aliases & Descriptions:

Name: Testicular Cancer 8 42 10 44 33
Cancer of the Testes 42 62
Neoplasm of Testis 8 62
Malignant Neoplasm of Testis 62
Carcinoma of the Testis 62
 
Testicular Neoplasms 62
Testicular Carcinoma 44
Testicular Tumor 8
Testis Neoplasm 8
Testis Cancer 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:2998
NCIt39 C3404
OMIM46 273300
MeSH34 D013736
ICD1025 C62

Related Diseases for Testicular Cancer

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Diseases related to Testicular Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1germ cell cancer31.2AFP, CGA
2male germ cell tumor, somatic31.1AFP, CGA
3endodermal sinus tumor30.7AFP
4cryptorchidism30.6CGB5, CGA, INSL3, AZF1
5gynecomastia30.5CGB5, CGA
6teratoma30.4AFP, CGB, CGA, CGB5
7hypospadias30.4INSL3, CGA
8extragonadal germ cell tumor30.4CGB5, AFP
9leydig cell tumor30.4CGB5, CGA
10infertility30.4CGA, CGB, INSL3, AZF1
11testicular disease30.3CGA, INSL3
12male infertility30.3CGA, AZF1
13klinefelter's syndrome30.2CGA, CGB, AZF1
14hypogonadism30.2CGB5, CGA
15oligospermia30.1CGB5, CGA, AZF1
16embryonal cancer30.1AFP, CGB, CGA, CGB5
17choriocarcinoma30.1AFP, CGB, CGA, CGB5
18prostate cancer30.1CGB, XAGE1D
19seminoma30.0CGB5, CGA, CGB, SSX2, AFP
20germinoma29.9AFP, CGB, CGA, CGB5
21azoospermia29.8AZF1, INSL3, CGA, CGB5
22adenocarcinoma29.6AFP, XAGE1D, CGB, CGB5
23sarcoma29.6SSX2, CGB, CGB5
24germ cell tumors10.5
25testicular microlithiasis10.5
26oligohydramnios10.5AFP
27anencephaly10.4CGA, AFP
28edwards syndrome10.3CGA, AFP
29encephalitis10.3
30prostatitis10.3
31varicocele10.3CGA, AZF1
32sarcoidosis10.3
33congenital adrenal hyperplasia10.3
34rete testis neoplasm10.3
35turner syndrome10.3CGA, CGB
36dermatomyositis10.3
37limbic encephalitis10.3
38trophoblastic neoplasm10.2CGB5, CGA
39ovarian cyst10.2CGB5, CGA
40ovarian hyperstimulation syndrome10.2CGB5, CGA
41precocious puberty10.2CGB5, CGA
42kallmann syndrome10.2CGA, CGB5
43breast cancer10.2
44kidney disease10.2
45mature teratoma10.2
46polycystic ovary syndrome10.2CGA, CGB5
47cryptococcosis10.2CGB, CGB5
48dysgerminoma10.2CGB5, CGA, AFP
49prolactinoma10.1CGA, CGB
50adenomatoid tumor10.1

Graphical network of the top 20 diseases related to Testicular Cancer:



Diseases related to testicular cancer

Symptoms for Testicular Cancer

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Clinical features from OMIM:

273300

Drugs & Therapeutics for Testicular Cancer

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Drug clinical trials:

Search ClinicalTrials for Testicular Cancer

Search NIH Clinical Center for Testicular Cancer

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Testicular Cancer

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Anatomical Context for Testicular Cancer

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MalaCards organs/tissues related to Testicular Cancer:

32
Testis, Testes, Lymph node, Skin, Prostate, Lung, Kidney, Breast, Brain, Heart, Pituitary, Bone, Liver, Spleen, Colon, Myeloid, Endothelial, Pineal

FMA organs/tissues related to Testicular Cancer:

14
The testicles

Animal Models for Testicular Cancer or affiliated genes

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Publications for Testicular Cancer

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Articles related to Testicular Cancer:

(show top 50)    (show all 634)
idTitleAuthorsYear
1
Reply: Comment on 'Chemotherapy for testicular cancer induces acute alterations in diastolic heart function'. (24201753)
2014
2
Genetic and epigenetic analysis of monozygotic twins discordant for testicular cancer. (25379132)
2014
3
Androgen receptor polymorphisms and testicular cancer risk. (25180665)
2014
4
International testicular cancer incidence trends: generational transitions in 38 countries 1900-1990. (25388800)
2014
5
Selective induction of glutathione S-transferases in round spermatids from the Brown-Norway rat by the chemotherapeutic regimen for testicular cancer. (23200778)
2013
6
Surgery for treatment of metastatic testicular cancer. (24171695)
2013
7
Bilateral germ-cell testicular cancer - long-term experience. (24320591)
2013
8
Effect of endogenous and exogenous hormones on testicular cancer: the epidemiological evidence. (23784836)
2013
9
Current management of testicular cancer. (23362440)
2013
10
Age at puberty and risk of testicular cancer: a meta-analysis. (22713104)
2012
11
Probability of metachronous testicular cancer in patients with biopsy-proven intratubular germ cell neoplasia depends on first-time treatment of germ cell cancer. (23071246)
2012
12
Impact of long-term serum platinum concentrations on neuro- and ototoxicity in Cisplatin-treated survivors of testicular cancer. (22184390)
2012
13
Testicular cancer. (22846486)
2012
14
Testicular cancer and the tuberous sclerosis complex. (21767201)
2012
15
Retroperitoneal lymphadenectomy and resection for testicular cancer: an update on best practice. (22852029)
2012
16
The clinical utility of testicular cancer risk loci. (21255381)
2011
17
Minimally invasive retroperitoneal lymph node dissection for testicular cancer. (22045176)
2011
18
Initial series of robot-assisted laparoscopic retroperitoneal lymph node dissection for clinical stage I nonseminomatous germ cell testicular cancer. (21420231)
2011
19
The pituitary-Leydig cell axis before and after orchiectomy in patients with stage I testicular cancer. (21704509)
2011
20
PET in testicular cancer. (21331937)
2011
21
A stratified genetic risk assessment for testicular cancer. (21564132)
2011
22
The predictive value of testicular ultrasound abnormalities for carcinoma in situ of the testis in men at risk for testicular cancer. (19845800)
2010
23
Testicular cancer. Does the dose intensity of BeP chemotherapy affect survival? (20836283)
2010
24
Vascular damage in testicular cancer patients: a study on endothelial activation by bleomycin and cisplatin in vitro. (19956889)
2010
25
Emotional disorders in testicular cancer survivors in relation to hypogonadism, androgen receptor polymorphism and treatment modality. (19656574)
2010
26
Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer. (20811155)
2010
27
Long-term neurologic and peripheral vascular toxicity after chemotherapy treatment of testicular cancer. (20225230)
2010
28
Optimal management of testicular cancer: from self-examination to treatment of advanced disease. (24198622)
2010
29
A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer--experiences of the son. (20660640)
2010
30
Prenatal DDT exposure and testicular cancer: a nested case-control study. (20705572)
2010
31
Simultaneous bilateral spontaneous pneumothorax in metastatic testicular cancer. (19140040)
2009
32
Upper gastrointestinal bleeding from metastatic testicular cancer. (19715045)
2009
33
Factors associated with testicular self-examination among unaffected men from multiple-case testicular cancer families. (19480691)
2009
34
Surgical management of low-stage nonseminomatous germ cell testicular cancer. (19840014)
2009
35
Contemporary radiological imaging of testicular cancer. (19840010)
2009
36
Diagnosis and treatment of testicular cancer. (18326165)
2008
37
A case of spermatic cord teratoma in low-stage testicular cancer managed by surveillance. (18268549)
2008
38
Subfertility among parents of men diagnosed with testicular cancer. (17822418)
2008
39
Gynaecomastia: an endocrine manifestation of testicular cancer. (18477201)
2008
40
Laparoscopic retroperitoneal lymph node dissection for low-stage testicular cancer. (18613781)
2008
41
A case of metastatic testicular cancer complicated by tumour lysis syndrome and choriocarcinoma syndrome. (16935862)
2006
42
A case of Sweet's syndrome following septic pulmonary emboli after high-dose chemotherapy for advanced testicular cancer. (16734883)
2006
43
XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer. (14723995)
2004
44
Asessment of paraneoplastic limbic encephalitis in testicular cancer. (12846502)
2003
45
MRP expression of testicular cancers and its clinical relevance. (11268495)
2000
46
Expression of proteins correlated with the unique cisplatin-sensitivity of testicular cancer. (9066679)
1997
47
Testicular cancer in association with developmental renal anomalies and hypospadias. (8560668)
1996
48
High-dose treatment with carboplatin, etoposide, and ifosfamide followed by autologous stem-cell transplantation in relapsed or refractory germ cell cancer: a phase I/II study. The German Testicular Cancer Cooperative Study Group. (7911158)
1994
49
Early clinical stages (CS1, CS1Mk+ and CS2A) of non-seminomatous testis cancer. Value of pre- and post-orchiectomy serum tumor marker information in prediction of retroperitoneal lymph node metastases. Swedish-Norwegian Testicular Cancer Project (SWENOTECA). (1702312)
1990
50
A case of complete remission obtained with etoposide cis-platinum combination chemotherapy in advanced testicular cancer]. (1689134)
1990

Variations for Testicular Cancer

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Expression for genes affiliated with Testicular Cancer

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Expression patterns in normal tissues for genes affiliated with Testicular Cancer

Search GEO for disease gene expression data for Testicular Cancer.

Pathways for genes affiliated with Testicular Cancer

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Pathways related to Testicular Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3CGB5, CGA, CGB

Compounds for genes affiliated with Testicular Cancer

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Compounds related to Testicular Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
111-ketotestosterone4410.0CGA, CGB5
2organon4410.0CGB5, CGA
3thyroxine44 2411.0CGA, CGB, AFP
4trilostane44 1111.0CGA, CGB5
5estradiol benzoate4410.0CGB5, CGA
617-hydroxypregnenolone4410.0CGB5, CGA
7leuprolide44 61 28 1113.0CGB5, CGA
8dihydroprogesterone4410.0CGB5, CGA
9cetrorelix44 28 1111.9CGB5, CGA
108-bromo-cyclic amp449.9CGB5, CGA
1122r-hydroxycholesterol44 2810.9CGA, CGB5
12leuprolide acetate449.9CGB5, CGA
13buserelin44 28 1111.9CGB5, CGA
14lutein449.9CGA, CGB5
15(+-)-pgf2-alpha449.8CGA, CGB5
1625-hydroxycholesterol44 28 2411.8CGA, CGB5
17percoll449.8CGA, CGB5
18vinblastine44 50 1111.7AFP, CGB5, CGA
1917-hydroxyprogesterone44 2410.7CGB5, CGA
20ctp449.7CGA, CGB, CGB5
21androstenedione44 2410.7CGB5, CGA, CGB
22vincristine44 50 1111.7AFP, CGB, CGB5
233beta-hydroxysteroid449.7CGA, INSL3, CGB5
24folate449.6AFP, CGA, CGB5
25dmso449.6CGB5, CGA, AFP
26naloxone44 28 50 1112.6CGB5, CGA
27gnrh449.5CGB5, CGB, CGA
28oestriol449.5CGB5, CGA, CGB, AFP
29clomiphene citrate449.5AFP, CGB5, CGB, CGA
30ifosfamide44 1110.5AFP, CGB, CGA, CGB5
31bleomycin44 1110.5CGB5, CGA, AFP, CGB
32mifepristone44 28 61 1112.5CGA, CGB5, AFP, CGB
33cyclophosphamide44 50 1111.5CGB, AFP, CGA, CGB5
34methotrexate50 44 1111.5CGB, AFP, CGA, CGB5
35diethylstilbestrol44 28 1111.5INSL3, AFP, CGB5, CGA
36etoposide44 50 61 1112.5CGB5, CGA, AFP, CGB
37epinephrine44 24 1111.4AFP, CGA, CGB5
38estradiol44 24 1111.4CGB5, CGA, CGB, AFP
39lactate449.4CGA, CGB5, CGB, AFP
40cisplatin44 50 61 1112.4CGB, AFP, CGA, CGB5
41creatinine449.4CGB, AFP, CGA, CGB5
42alanine449.3CGB, INSL3, AFP, CGA
43progesterone44 28 61 24 1113.3AFP, CGA, CGB, CGB5
44nitrate449.3CGB5, AFP
45cyclic amp44 2410.3CGA, CGB, INSL3, CGB5
46steroid449.2CGA, CGB5, AFP, INSL3
47testosterone44 61 24 1112.1CGB, CGB5, CGA, AFP, INSL3
48ethanol44 50 24 1112.1AFP, ACPT, CGB5
49estrogen449.1INSL3, AFP, CGB, CGA, CGB5
50vegf449.1CGB, CGA, CGB5, AFP

GO Terms for genes affiliated with Testicular Cancer

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Biological processes related to Testicular Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.6CGA, CGB
2cell-cell signalingGO:0072679.6CGA, CGB, INSL3

Molecular functions related to Testicular Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6CGA, CGB, INSL3

Products for genes affiliated with Testicular Cancer

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  • Antibodies
  • Proteins
  • Lysates

Sources for Testicular Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet