MCID: TST014
MIFTS: 58

Testicular Cancer malady

Cancer diseases, Reproductive diseases categories

Summaries for Testicular Cancer

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Sources:
33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Testicles, or testes, make male hormones and sperm. they are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. you can get cancer in one or both testicles. testicular cancer mainly affects young men between the ages of 20 and 39. it is also more common in men who have had abnormal testicle development have had an undescended testicle have a family history of the cancer symptoms include pain, swelling, or lumps in your testicles or groin area. doctors use a physical exam, lab tests, imaging tests, and a biopsy to diagnose testicular cancer. most cases can be treated, especially if found early. treatment options include surgery, radiation, and/or chemotherapy. regular exams after treatment are important. treatments may also cause infertility. if you may want children later on, you should consider sperm banking before treatment. nih: national cancer institute

MalaCards: Testicular Cancer, also known as malignant neoplasm of testis, is related to cryptorchidism and seminoma. An important gene associated with Testicular Cancer is AFP (alpha-fetoprotein), and among its related pathways is Glycoprotein hormones. The drugs cyclophosphamide and cisplatin and the compounds oestriol and clomiphene citrate have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and lymph node.

Wikipedia:63 Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system. more...

Description from OMIM:46 273300

Aliases & Classifications for Testicular Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

testicular cancer 8 42 10 44 33
malignant neoplasm of testis 60
carcinoma of the testis 60
cancer of the testes 42
testicular carcinoma 44
testicular neoplasms 60
neoplasm of testis 8
testicular tumor 8
testis neoplasm 8
testis cancer 8


External Ids:

Disease Ontology8 DOID:2998
NCIt39 C3404
MeSH34 D013736
OMIM46 273300
ICD1025 C62

Related Diseases for Testicular Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Testicular Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1cryptorchidism30.6AZF1, CGA, CGB5
2seminoma30.5CGA, CGB5, CGB, AFP, SSX2, MAGEA1
3prostate cancer30.5CTAG1B, CGB, XAGE1D
4lung cancer30.4CCNA1, CTAG1B, CGB, MAGEA3, MAGEA1, MAGEA4
5infertility30.4AZF1, CGA, CGB, TRO
6male germ cell tumor, somatic30.4CGA, AFP
7breast cancer30.3CCNA1, CTAG1B, CGB, SSX2, MAGEA3, MAGEA1
8embryonal cancer30.2CGA, CGB5, CGB, AFP
9gynecomastia30.1CGA, CGB5
10leukemia30.1CCNA1, CTAG1B, CGB, MAGEA3, MAGEA1
11choriocarcinoma30.1CGA, CGB5, CGB, AFP
12ovarian cancer29.9CTAG1B, CGB5, CGB, PRSS21, AFP, SSX2
13sarcoma29.9CTAG1B, CGB5, CGB, SSX2, MAGEA3, MAGEA1
14oligospermia29.9CGB5, CGA, AZF1
15leydig cell tumor29.9CGB5, CGA
16azoospermia29.9AZF1, CGA, CGB5
17colorectal cancer29.9MAGEA1, MAGEA3, CGB
18klinefelter's syndrome29.9AZF1, CGA, CGB
19endodermal sinus tumor29.9AFP
20retroperitoneal cancer10.7
21lymph node cancer10.7
22testicular disease10.5
23vascular cancer10.4
24embryonal testis carcinoma10.3
25encephalitis10.3
26prostatitis10.3
27sarcoidosis10.3
28dermatomyositis10.2
29kidney cancer10.2
30congenital adrenal hyperplasia10.2
31rete testis neoplasm10.2
32testicular lymphoma10.2
33brain cancer10.2
34heart cancer10.2
35hypogonadism10.2
36kidney disease10.2
37mature teratoma10.2
38pituitary cancer10.2
39polyarteritis nodosa10.1
40hypercalcemia10.1
41astrocytoma10.1
42malignant leydig cell tumor10.1
43mixed germ cell cancer10.1
44acute leukemia10.1
45hyperthyroidism10.1
46adenomatoid tumor10.1
47adrenal carcinoma10.1
48male breast cancer10.1
49testicular leukemia10.1
50testicular infarct10.1

Graphical network of the top 20 diseases related to Testicular Cancer:



Diseases related to testicular cancer

Clinical Features for Testicular Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

273300

Drugs & Therapeutics for Testicular Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Testicular Cancer

Drug clinical trials:

Search ClinicalTrials for Testicular Cancer

Search NIH Clinical Center for Testicular Cancer

Search CenterWatch for Testicular Cancer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Testicular Cancer

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Anatomical Context for Testicular Cancer

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Sources:
32MalaCards
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MalaCards organs/tissues related to Testicular Cancer:

32
Testis, Testes, Lymph node, Skin, Prostate, Breast, Lung, Kidney, Pituitary, Heart, Brain, Liver, Bone, Colon, Spleen, B cells, Endothelial, Pineal, Myeloid

Animal Models for Testicular Cancer or affiliated genes

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Publications for Testicular Cancer

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Sources:
50PubMed
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Articles related to Testicular Cancer:

(show top 50)    (show all 771)
idTitleAuthorsYear
1
Surgery for treatment of metastatic testicular cancer. (24171695)
2013
2
Risk factors for chronic kidney disease after chemotherapy for testicular cancer. (23186076)
2013
3
Patterns of management and surveillance imaging amongst medical oncologists in Australia for stage I testicular cancer. (23795796)
2013
4
Genome-wide assessment of the association of rare and common copy number variations to testicular germ cell cancer. (23372565)
2013
5
Thrombocytopenia following high-dose chemotherapy with carboplatin, etoposide and thiotepa in patients with testicular germ cell cancer. (23260006)
2013
6
A meta-analysis of the risk of boys with isolated cryptorchidism developing testicular cancer in later life. (23193201)
2013
7
Advanced testicular cancer in a society of racial and socio-economic health disparity. (23813997)
2013
8
The prevalence and correlates of supportive care needs in testicular cancer survivors: a cross-sectional study. (23825010)
2013
9
Testicular cancer in Europe and the USA: survival still rising among older patients. (23110807)
2013
10
Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer. (22245602)
2012
11
Analysis of genetic interactions involving maternal and offspring genotypes at different Loci: power simulation and application to testicular cancer. (22740241)
2012
12
Automated tube potential selection for standard chest and abdominal CT in follow-up patients with testicular cancer: comparison with fixed tube potential. (22549104)
2012
13
Re: Global trends in testicular cancer incidence and mortality. (22579179)
2012
14
Large teratoma at aortic bifurcation: an unusual metastasis of testicular cancer. (22512966)
2012
15
Clinical impact of residual extraretroperitoneal masses in patients with advanced nonseminomatous germ cell testicular cancer. (22202548)
2012
16
Testicular cancer and HPV semen infection. (23267350)
2012
17
Optimization of cisplatin doses in a testicular cancer patient with acute renal failure. (19933251)
2011
18
The possible role of hemochromatosis in testicular cancer. (21549511)
2011
19
Summaries for patients: screening for testicular cancer: U.S. Preventive Services Task Force reaffirmation recommendation statement. (21464345)
2011
20
Emotional disorders in testicular cancer survivors in relation to hypogonadism, androgen receptor polymorphism and treatment modality. (19656574)
2010
21
Cardiovascular risk factors and morbidity in long-term survivors of testicular cancer: a 20-year follow-up study. (20855830)
2010
22
Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. (20543847)
2010
23
Cervical lymph node dissection for metastatic testicular cancer. (20333552)
2010
24
Testicular cancer. Surveillance or biopsy for men with testicular microlithiasis? (20836284)
2010
25
Retroperitoneal lymph node dissection in patients with high risk testicular cancer. (19286227)
2009
26
Levels of circulating interleukin-1 receptor antagonist and C-reactive protein in long-term survivors of testicular cancer with chronic cancer-related fatigue. (19362138)
2009
27
What is the value of routine follow-up in stage I seminoma after paraaortic radiotherapy?: an analysis of the German Testicular Cancer Study Group (GTCSG) in 675 prospectively followed patients. (19506817)
2009
28
Subfertility among parents of men diagnosed with testicular cancer. (17822418)
2008
29
Chemotherapy as an alternative to radiotherapy in the treatment of stage IIA and IIB testicular seminoma: a Spanish Germ Cell Cancer Group Study. (18936476)
2008
30
Characterization of sperm chromatin quality in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy. (18346994)
2008
31
Treatment experiences of testicular cancer in Hispanic patients with Down's syndrome at the National Cancer Institute of Mexico. (19015076)
2008
32
Complications of laparoscopic retroperitoneal lymph node dissection in testicular cancer. (18594824)
2008
33
Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drug-sensitive tumor, testicular cancer. (18813353)
2008
34
Combination chemotherapy with gemcitabine, oxaliplatin, and paclitaxel in patients with cisplatin-refractory or multiply relapsed germ-cell tumors: a study of the German Testicular Cancer Study Group. (18006893)
2008
35
Host factors, occupation, and testicular cancer in Saskatchewan, Canada: 1979-2002. (17892068)
2007
36
College men's knowledge, attitudes, and beliefs about testicular cancer. (19482795)
2007
37
Maternal hormone levels among populations at high and low risk of testicular germ cell cancer. (15841083)
2005
38
Testicular cancer: seminoma. (16620449)
2005
39
Successful cure of dermatomyositis after treatment of nonseminomatous testicular cancer. (15985087)
2005
40
Combination chemotherapy with gemcitabine plus oxaliplatin in patients with intensively pretreated or refractory germ cell cancer: a study of the German Testicular Cancer Study Group. (14701772)
2004
41
Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers. (11920956)
2002
42
Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer. (12483540)
2002
43
Routine chest X-rays have no additional value in the detection of relapse during routine follow-up of patients treated with chemotherapy for disseminated non-seminomatous testicular cancer. (12377651)
2002
44
Decreased telomerase activity is not a reliable indicator of chemosensitivity in testicular cancer cell lines. (11872354)
2002
45
Testicular pathology in 46,XY dysgenetic male pseudohermaphroditism: an approach to pathogenesis of testis cancer. (11545290)
2001
46
Unique expression patterns of H19 in human testicular cancers of different etiology. (9010236)
1997
47
Tumour marker concentration at the start of chemotherapy is a stronger predictor of treatment failure than marker half-life: a study in patients with disseminated non-seminomatous testicular cancer. (9020492)
1997
48
Elevated serum tumor markers in patients with testicular cancer after induction chemotherapy due to a reservoir of markers in cystic differentiated mature teratoma. (1706441)
1991
49
Metastatic testicular cancer and extragonadal germ cell tumor presenting with neurological symptoms. (2162914)
1990
50
Testicular spermatogenic cell hypertrophy accompanying prostatic hypertrophy and cancer. (13302394)
1956

Genetic Variations for Testicular Cancer

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Expression for genes affiliated with Testicular Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Testicular Cancer

Search GEO for disease gene expression data for Testicular Cancer.

Pathways for genes affiliated with Testicular Cancer

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53Reactome
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Pathways related to Testicular Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6CGB, CGA

Compounds for genes affiliated with Testicular Cancer

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Testicular Cancer according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1oestriol4411.0AFP, CGB, CGB5, CGA
2clomiphene citrate4411.0CGA, CGB5, CGB, AFP
3ifosfamide44 1112.0AFP, CGB, CGB5, CGA
4bleomycin44 1112.0CGA, CGB5, CGB, AFP
5paraffin4411.0CGA, CGB5, AFP, MAGEA3, MAGEA1
6mifepristone44 59 28 1114.0CGA, CGB5, CGB, AFP
7cyclophosphamide44 49 1113.0AFP, CGB, CGB5, CGA
8ctp4411.0CGB, CGB5, CGA
9methotrexate44 49 1113.0CGA, CGB5, CGB, AFP
105-aza-2deoxycytidine4410.9CTAG1B, SSX2, BAGE, MAGEA1
11etoposide44 49 59 1113.9CGA, CGB5, CGB, AFP
12diethylstilbestrol44 28 1112.9AFP, CGB5, CGA
1311-ketotestosterone4410.9CGA, CGB5
14vinblastine44 49 1112.9AFP, CGB5, CGA
15organon4410.9CGA, CGB5
16androstenedione44 2411.9CGB, CGB5, CGA
17trilostane44 1111.8CGB5, CGA
18estradiol benzoate4410.8CGA, CGB5
1917-hydroxypregnenolone4410.8CGA, CGB5
20leuprolide44 59 28 1113.8CGA, CGB5
21dihydroprogesterone4410.8CGB5, CGA
22cetrorelix44 28 1112.8CGA, CGB5
23vincristine44 49 1112.7AFP, CGB, CGB5
248-bromo-cyclic amp4410.7CGA, CGB5
2522r-hydroxycholesterol44 2811.7CGA, CGB5
26vegf4410.7AFP, CGB, CGB5, CGA, CCNA1
27leuprolide acetate4410.6CGB5, CGA
28buserelin44 28 1112.6CGB5, CGA
29estradiol44 11 2412.5CGA, CGB5, CGB, AFP
30lutein4410.2CGB5, CGA

GO Terms for genes affiliated with Testicular Cancer

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16Gene Ontology
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Biological processes related to Testicular Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:01648610.6CGB, CGA

Products for genes affiliated with Testicular Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Testicular Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet