MCID: TST014
MIFTS: 55

Testicular Cancer malady

Cancer, Reproductive categories

Summaries for Testicular Cancer

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Testicles, or testes, make male hormones and sperm. they are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. you can get cancer in one or both testicles. testicular cancer mainly affects young men between the ages of 20 and 39. it is also more common in men who have had abnormal testicle development have had an undescended testicle have a family history of the cancer symptoms include pain, swelling, or lumps in your testicles or groin area. doctors use a physical exam, lab tests, imaging tests, and a biopsy to diagnose testicular cancer. most cases can be treated, especially if found early. treatment options include surgery, radiation, and/or chemotherapy. regular exams after treatment are important. treatments may also cause infertility. if you may want children later on, you should consider sperm banking before treatment. nih: national cancer institute

MalaCards: Testicular Cancer, also known as malignant neoplasm of testis, is related to cryptorchidism and infertility. An important gene associated with Testicular Cancer is AFP (alpha-fetoprotein), and among its related pathways is Glycoprotein hormones. The drugs chlorambucil and cisplatin and the compounds oestriol and clomiphene citrate have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spleen and brain.

Wikipedia:64 Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system. more...

Description from OMIM:47 273300

Aliases & Classifications for Testicular Cancer

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 47OMIM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Reproductive


Aliases & Descriptions:

testicular cancer 8 43 10 45 34
malignant neoplasm of testis 61
carcinoma of the testis 61
cancer of the testes 43
testicular carcinoma 45
testicular neoplasms 61
neoplasm of testis 8
testicular tumor 8
testis neoplasm 8
testis cancer 8


External Ids:

Disease Ontology8 DOID:2998
NCIt40 C3404
MeSH35 D013736
OMIM47 273300
ICD1025 C62

Related Diseases for Testicular Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Testicular Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1cryptorchidism30.6AZF1, CGB5, CGA
2infertility30.4TRO, CGA, AZF1, CGB
3teratoma30.4CGA, CGB5, CGB, AFP
4gynecomastia30.1CGA, CGB5
5germinoma29.9AFP, CGB5, CGA, CGB
6extragonadal germ cell tumor29.9AFP, CGB5
7oligospermia29.9CGA, CGB5, AZF1
8azoospermia29.9CGA, AZF1, CGB5
9colorectal cancer29.9CGB, MAGEA3, MAGEA1
10klinefelter's syndrome29.9AZF1, CGB, CGA
11germ cell cancer10.8
12testicular disease10.5
13testicular germ cell tumor10.5
14testicular microlithiasis10.5
15germ cell tumors10.5
16vascular cancer10.4
17limbic encephalitis10.3
18congenital adrenal hyperplasia10.2
19testicular lymphoma10.2
20brain cancer10.2
21testicular cancer, childhood10.2
22testicular tumor, somatic10.2
23polyarteritis nodosa10.1
24hypercalcemia10.1
25astrocytoma10.1
26acute leukemia10.1
27acute myelomonocytic leukemia10.1
28male breast cancer10.1
29testicular leukemia10.1
30testicular infarct10.1
31cardia cancer10.1
32hypospadias10.1
33n syndrome10.1
34testicular malignant germ cell cancer10.1
35nonseminomatous germ cell tumor10.1
36adenomatoid tumor10.1
37adrenal carcinoma10.1
38adenoma10.1
39sertoli cell tumor10.1
40mixed germ cell tumor10.1
41testis refractory cancer10.1
42testis sarcoma10.1
43cerebellar degeneration10.0
44ovarian cancer10.0SPA17, MAGEA1, MAGEA3, AFP, CGB, CGB5
45adenocarcinoma10.0CTAG1B, CGB5, AFP, MAGEA1, MAGEA4, XAGE1D
46melanoma10.0CGB, CTAG1B, BAGE, MAGEA3, SSX2, MAGEA1
47seminoma10.0MAGEA4, MAGEA1, AFP, CGB, CGB5, CGA
48sarcoma10.0CGB5, CGB, SSX2, MAGEA3, MAGEA1, MAGEA4
49lung cancer10.0MAGEA1, MAGEA3, CGB, CCNA1, XAGE1D, MAGEA4
50breast cancer10.0CCNA1, CTAG1B, MAGEA1, CGB, SSX2, MAGEA3

Graphical network of the top 20 diseases related to Testicular Cancer:



Diseases related to testicular cancer

Clinical Features for Testicular Cancer

Sources:
47OMIM
See all sources

Clinical features from OMIM:

273300

Drugs & Therapeutics for Testicular Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Testicular Cancer

Drug clinical trials:

Search ClinicalTrials for Testicular Cancer

Search NIH Clinical Center for Testicular Cancer

Search CenterWatch for Testicular Cancer

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Testicular Cancer

Anatomical Context for Testicular Cancer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Testicular Cancer:

33
Lymph node, Spleen, Brain, Spinal cord, Heart, Small intestine, Colon, Kidney, Liver, Lung, Breast, Skin, Prostate, Testis, Myeloid, T cells, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Pineal, Pituitary, Testis germ, Testis leydig

Animal Models for Testicular Cancer or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Testicular Cancer

Sources:
51PubMed
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Articles related to Testicular Cancer:

(show top 50)    (show all 771)
idTitleAuthorsYear
1
Selective induction of glutathione S-transferases in round spermatids from the Brown-Norway rat by the chemotherapeutic regimen for testicular cancer. (23200778)
2013
2
Lower gastrointestinal bleeding as a result of fistula between the iliac artery and sigmoid colon in patient with advanced testicular cancer. (24267117)
2013
3
Post-chemotherapy nerve-sparing laparoscopic retroperitoneal lymph node dissection in stage IIB testicular cancer. (23305547)
2013
4
Frequency of computed tomography examinations in the follow-up care of testicular cancer patients - an evaluation of patterns of care in Germany. (23548967)
2013
5
Increased chemosensitivity via targeting testicular nuclear receptor 4 (TR4)-Oct4-interleukin 1 receptor antagonist (IL1Ra) axis in prostate cancer CD133+ stem/progenitor cells to battle prostate cancer. (23609451)
2013
6
Expression analysis of RNA-binding motif gene on Y chromosome (RBMY) protein isoforms in testis tissue and a testicular germ cell cancer-derived cell line (NT2). (23567846)
2013
7
Age at puberty and risk of testicular cancer: a meta-analysis. (22713104)
2012
8
Chemotherapy-induced infertility in patients with testicular cancer. (22201652)
2012
9
Intermediate-term oncological efficacy of laparoscopic retroperitoneal lymph node dissection for non-seminomatous germ cell testicular cancer. (21631699)
2012
10
Sexuality and body image in long-term survivors of testicular cancer. (22197218)
2012
11
Fetal radiation exposure induces testicular cancer in genetically susceptible mice. (22348147)
2012
12
Rare de novo germline copy-number variation in testicular cancer. (22863192)
2012
13
The pituitary-Leydig cell axis before and after orchiectomy in patients with stage I testicular cancer. (21704509)
2011
14
A prospective study of neuropsychological functioning in testicular cancer patients. (21048038)
2011
15
Re: Management of seminomatous testicular cancer: a binational prospective population-based study from the Swedish Norwegian testicular cancer study group. (22078586)
2011
16
Preclinical and clinical activity of sunitinib in patients with cisplatin-refractory or multiply relapsed germ cell tumors: a Canadian Urologic Oncology Group/German Testicular Cancer Study Group cooperative study. (21415240)
2011
17
Androgen substitution with testosterone undecanoate in survivors of bilateral testicular cancer requires individually-adjusted injection intervals. (20825398)
2011
18
The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancers. (20395447)
2010
19
Romantic and sexual relationships, body image, and fertility in adolescent and young adult testicular cancer survivors: a review of the literature. (20638003)
2010
20
Incidence of testicular cancer in the United States, 1999-2004. (20031937)
2010
21
Getting to the root of testicular cancer. (20844408)
2010
22
Testicular cancer: current management and controversial issues. (20535288)
2010
23
Epidemiological features of testicular cancer in the Slovak Republic--retrospective study. (19522374)
2009
24
Testicular cancer: addressing the psychosexual issues. (19966744)
2009
25
A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer--experiences of the mother. (19776243)
2009
26
Advances made in the treatment of testicular cancer in the U.S. Military: 1946 to the present. (19720302)
2009
27
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. (19483682)
2009
28
Postchemotherapy retroperitoneal lymph node dissection in advanced testicular cancer: radical or modified template resection. (18926622)
2009
29
Semen quality in men with disseminated testicular cancer: relation with human chorionic gonadotropin beta-subunit and pituitary gonadal hormones. (18440530)
2009
30
Short- and long-term morbidity after treatment for testicular cancer. (19840023)
2009
31
Mismatch repair expression in testicular cancer predicts recurrence and survival. (18076065)
2008
32
Chronic cancer-related fatigue in long-term survivors of testicular cancer. (18374735)
2008
33
National Academy of Clinical Biochemistry laboratory medicine practice guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers. (19042984)
2008
34
Trends in testicular germ cell cancer incidence in Australia. (18478339)
2008
35
Maternal Epstein-Barr virus and cytomegalovirus infections and risk of testicular cancer in the offspring: a nested case-control study. (19024602)
2008
36
Drosophila spermatogenesis: insights into testicular cancer. (17573852)
2007
37
Correction of cryptorchidism and testicular cancer. (17717860)
2007
38
Sperm integrity pre- and post-chemotherapy in men with testicular germ cell cancer. (16601009)
2006
39
Randomized trial of 30 versus 20 Gy in the adjuvant treatment of stage I testicular seminoma: a report on Medical Research Council Trial TE18, European Organisation for Research and Treatment of Cancer Trial 30942 (ISRCTN18525328). (16170196)
2005
40
ATM activation in normal human tissues and testicular cancer. (15846060)
2005
41
Marked increase of the growth factors pleiotrophin and fibroblast growth factor-2 in serum of testicular cancer patients. (14504053)
2003
42
Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle. (14501716)
2003
43
Calcium-sensing receptor induces messenger ribonucleic acid of human securin, pituitary tumor transforming gene, in rat testicular cancer. (12970167)
2003
44
Irinotecan in patients with relapsed or cisplatin-refractory germ cell cancer: a phase II study of the German Testicular Cancer Study Group. (12966438)
2003
45
Expression of peroxisome proliferator-activated receptors in human testicular cancer and growth inhibition by its agonists. (12350514)
2002
46
Testicular microlithiasis: what is its association with testicular cancer? (11425975)
2001
47
A prospect of molecular biology in the field of urologic oncology: mechanisms of carcinogenesis or tumor development in testicular cancer]. (11771175)
2001
48
Gonadal function after multimodality treatment in men with testicular germ cell cancer. (8640293)
1996
49
Gonadal function in men with testicular germ cell cancer: the influence of cisplatin-based chemotherapy. (8386643)
1993
50
Risk of bilateral testicular germ cell cancer in Denmark: 1960-1984. (1656057)
1991

Genetic Variations for Testicular Cancer

Expression for genes affiliated with Testicular Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Testicular Cancer

Search GEO for disease gene expression data for Testicular Cancer.

Pathways for genes affiliated with Testicular Cancer

Sources:
54Reactome
See all sources

Pathways related to Testicular Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6CGB, CGA

Compounds for genes affiliated with Testicular Cancer

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 24HMDB
See all sources

Compounds related to Testicular Cancer according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1oestriol4511.0AFP, CGB, CGB5, CGA
2clomiphene citrate4511.0CGA, CGB5, CGB, AFP
3ifosfamide45 1112.0AFP, CGB, CGB5, CGA
4bleomycin45 1112.0CGA, CGB5, CGB, AFP
5paraffin4511.0CGA, CGB5, AFP, MAGEA3, MAGEA1
6mifepristone45 60 29 1114.0CGA, CGB5, CGB, AFP
7cyclophosphamide45 50 1113.0AFP, CGB, CGB5, CGA
8ctp4511.0CGB, CGB5, CGA
9methotrexate45 50 1113.0CGA, CGB5, CGB, AFP
105-aza-2deoxycytidine4510.9CTAG1B, SSX2, BAGE, MAGEA1
11etoposide45 50 60 1113.9CGA, CGB5, CGB, AFP
12diethylstilbestrol45 29 1112.9AFP, CGB5, CGA
1311-ketotestosterone4510.9CGA, CGB5
14vinblastine45 50 1112.9AFP, CGB5, CGA
15organon4510.9CGA, CGB5
16androstenedione45 2411.9CGB, CGB5, CGA
17trilostane45 1111.8CGB5, CGA
18estradiol benzoate4510.8CGA, CGB5
1917-hydroxypregnenolone4510.8CGA, CGB5
20leuprolide45 60 29 1113.8CGA, CGB5
21dihydroprogesterone4510.8CGB5, CGA
22cetrorelix45 29 1112.8CGA, CGB5
23vincristine45 50 1112.7AFP, CGB, CGB5
248-bromo-cyclic amp4510.7CGA, CGB5
2522r-hydroxycholesterol45 2911.7CGA, CGB5
26vegf4510.7AFP, CGB, CGB5, CGA, CCNA1
27leuprolide acetate4510.6CGB5, CGA
28buserelin45 29 1112.6CGB5, CGA
29estradiol45 11 2412.5CGA, CGB5, CGB, AFP
30lutein4510.2CGB5, CGA

GO Terms for genes affiliated with Testicular Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Testicular Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:01648610.6CGB, CGA

Products for genes affiliated with Testicular Cancer

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  • Lysates
  • Antibodies

Sources for Testicular Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet