MCID: TST014
MIFTS: 58

Testicular Cancer malady

Rare diseases, Cancer diseases, Reproductive diseases categories
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Summaries for Testicular Cancer

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Sources:
34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Testicles, or testes, make male hormones and sperm. they are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. you can get cancer in one or both testicles. testicular cancer mainly affects young men between the ages of 20 and 39. it is also more common in men who have had abnormal testicle development have had an undescended testicle have a family history of the cancer symptoms include pain, swelling, or lumps in your testicles or groin area. doctors use a physical exam, lab tests, imaging tests, and a biopsy to diagnose testicular cancer. most cases can be treated, especially if found early. treatment options include surgery, radiation, and/or chemotherapy. regular exams after treatment are important. treatments may also cause infertility. if you may want children later on, you should consider sperm banking before treatment. nih: national cancer institute

MalaCards: Testicular Cancer, also known as malignant neoplasm of testis, is related to germ cell cancer and cryptorchidism. An important gene associated with Testicular Cancer is AFP (alpha-fetoprotein), and among its related pathways is Peptide hormone metabolism. The drugs cyclophosphamide and cisplatin and the compounds 11-ketotestosterone and organon have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and lymph node.

Wikipedia:65 Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system. more...

Description from OMIM:47 273300

Aliases & Classifications for Testicular Cancer

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 47OMIM, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

testicular cancer 8 43 10 45 34
malignant neoplasm of testis 62
carcinoma of the testis 62
cancer of the testes 43
testicular carcinoma 45
testicular neoplasms 62
neoplasm of testis 8
testicular tumor 8
testis neoplasm 8
testis cancer 8


External Ids:

Disease Ontology8 DOID:2998
OMIM47 273300
NCIt40 C3404
MeSH35 D013736
ICD1025 C62

Related Diseases for Testicular Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Testicular Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1germ cell cancer30.7AFP, CGA
2cryptorchidism30.7CGB5, CGA, INSL3, AZF1
3male germ cell tumor, somatic30.6AFP, CGA
4teratoma30.4AFP, CGB, CGA, CGB5
5infertility30.4CGA, CGB, INSL3, AZF1
6seminoma30.4CGB5, CGA, CGB, SSX2, AFP
7gynecomastia30.2CGB5, CGA
8hypospadias30.2INSL3, CGA
9embryonal cancer30.1AFP, CGB, CGA, CGB5
10hypogonadism30.1CGB5, CGA
11choriocarcinoma30.1AFP, CGB, CGA, CGB5
12endodermal sinus tumor30.1AFP
13extragonadal germ cell tumor30.0CGB5, AFP
14leydig cell tumor30.0CGB5, CGA
15klinefelter's syndrome30.0CGA, CGB, AZF1
16testicular disease30.0CGA, INSL3
17male infertility30.0CGA, AZF1
18oligospermia30.0CGB5, CGA, AZF1
19prostate cancer29.9CGB, XAGE1D
20germinoma29.9AFP, CGB, CGA, CGB5
21azoospermia29.9AZF1, INSL3, CGA, CGB5
22sarcoma29.8SSX2, CGB, CGB5
23germ cell tumors10.5
24testicular microlithiasis10.4
25encephalitis10.3
26prostatitis10.3
27sarcoidosis10.3
28congenital adrenal hyperplasia10.3
29rete testis neoplasm10.3
30dermatomyositis10.2
31limbic encephalitis10.2
32breast cancer10.2
33mature teratoma10.2
34adenomatoid tumor10.1
35hypercalcemia10.1
36astrocytoma10.1
3721-hydroxylase deficiency10.1
38testicular tumor, somatic10.1
39oligohydramnios10.1AFP
40male breast cancer10.1
41neuronitis10.1
42hodgkin's lymphoma10.1
43kidney disease10.1
44leukemia10.1
45testicular cancer, childhood10.1
46testicular germ cell tumor10.1
47anencephaly10.1CGA, AFP
48testis refractory cancer10.1
49malignant tumor of undescended testis10.1
50testis sarcoma10.1

Graphical network of the top 20 diseases related to Testicular Cancer:



Diseases related to testicular cancer

Symptoms for Testicular Cancer

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Sources:
47OMIM
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Clinical features from OMIM:

273300

Drugs & Therapeutics for Testicular Cancer

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Testicular Cancer

Search NIH Clinical Center for Testicular Cancer

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Testicular Cancer

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Anatomical Context for Testicular Cancer

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33MalaCards
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MalaCards organs/tissues related to Testicular Cancer:

33
Testis, Testes, Lymph node, Skin, Prostate, Lung, Breast, Heart, Kidney, Brain, Pituitary, Bone, Liver, Myeloid, Colon, Spleen, Pineal, Endothelial

Animal Models for Testicular Cancer or affiliated genes

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Publications for Testicular Cancer

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52PubMed
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Articles related to Testicular Cancer:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
Reply: Comment on 'Chemotherapy for testicular cancer induces acute alterations in diastolic heart function'. (24201753)
2014
2
Selective induction of glutathione S-transferases in round spermatids from the Brown-Norway rat by the chemotherapeutic regimen for testicular cancer. (23200778)
2013
3
Surgery for treatment of metastatic testicular cancer. (24171695)
2013
4
Bilateral germ-cell testicular cancer - long-term experience. (24320591)
2013
5
Effect of endogenous and exogenous hormones on testicular cancer: the epidemiological evidence. (23784836)
2013
6
Current management of testicular cancer. (23362440)
2013
7
Age at puberty and risk of testicular cancer: a meta-analysis. (22713104)
2012
8
Probability of metachronous testicular cancer in patients with biopsy-proven intratubular germ cell neoplasia depends on first-time treatment of germ cell cancer. (23071246)
2012
9
Impact of long-term serum platinum concentrations on neuro- and ototoxicity in Cisplatin-treated survivors of testicular cancer. (22184390)
2012
10
Testicular cancer. (22846486)
2012
11
Testicular cancer and the tuberous sclerosis complex. (21767201)
2012
12
Retroperitoneal lymphadenectomy and resection for testicular cancer: an update on best practice. (22852029)
2012
13
The clinical utility of testicular cancer risk loci. (21255381)
2011
14
Minimally invasive retroperitoneal lymph node dissection for testicular cancer. (22045176)
2011
15
Initial series of robot-assisted laparoscopic retroperitoneal lymph node dissection for clinical stage I nonseminomatous germ cell testicular cancer. (21420231)
2011
16
The pituitary-Leydig cell axis before and after orchiectomy in patients with stage I testicular cancer. (21704509)
2011
17
PET in testicular cancer. (21331937)
2011
18
The predictive value of testicular ultrasound abnormalities for carcinoma in situ of the testis in men at risk for testicular cancer. (19845800)
2010
19
Testicular cancer. Does the dose intensity of BeP chemotherapy affect survival? (20836283)
2010
20
Vascular damage in testicular cancer patients: a study on endothelial activation by bleomycin and cisplatin in vitro. (19956889)
2010
21
Emotional disorders in testicular cancer survivors in relation to hypogonadism, androgen receptor polymorphism and treatment modality. (19656574)
2010
22
Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer. (20811155)
2010
23
Long-term neurologic and peripheral vascular toxicity after chemotherapy treatment of testicular cancer. (20225230)
2010
24
Optimal management of testicular cancer: from self-examination to treatment of advanced disease. (24198622)
2010
25
A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer--experiences of the son. (20660640)
2010
26
Prenatal DDT exposure and testicular cancer: a nested case-control study. (20705572)
2010
27
SERPINE2 is a possible candidate promotor for lymph node metastasis in testicular cancer. (20035713)
2010
28
Simultaneous bilateral spontaneous pneumothorax in metastatic testicular cancer. (19140040)
2009
29
Upper gastrointestinal bleeding from metastatic testicular cancer. (19715045)
2009
30
Factors associated with testicular self-examination among unaffected men from multiple-case testicular cancer families. (19480691)
2009
31
Surgical management of low-stage nonseminomatous germ cell testicular cancer. (19840014)
2009
32
Contemporary radiological imaging of testicular cancer. (19840010)
2009
33
The association risk of male subfertility and testicular cancer: a systematic review. (19440348)
2009
34
Diagnosis and treatment of testicular cancer. (18326165)
2008
35
A case of spermatic cord teratoma in low-stage testicular cancer managed by surveillance. (18268549)
2008
36
Subfertility among parents of men diagnosed with testicular cancer. (17822418)
2008
37
Gynaecomastia: an endocrine manifestation of testicular cancer. (18477201)
2008
38
Laparoscopic retroperitoneal lymph node dissection for low-stage testicular cancer. (18613781)
2008
39
A case of metastatic testicular cancer complicated by tumour lysis syndrome and choriocarcinoma syndrome. (16935862)
2006
40
A case of Sweet's syndrome following septic pulmonary emboli after high-dose chemotherapy for advanced testicular cancer. (16734883)
2006
41
XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer. (14723995)
2004
42
Asessment of paraneoplastic limbic encephalitis in testicular cancer. (12846502)
2003
43
MRP expression of testicular cancers and its clinical relevance. (11268495)
2000
44
Expression of proteins correlated with the unique cisplatin-sensitivity of testicular cancer. (9066679)
1997
45
Unique expression patterns of H19 in human testicular cancers of different etiology. (9010236)
1997
46
Testicular cancer in association with developmental renal anomalies and hypospadias. (8560668)
1996
47
High-dose treatment with carboplatin, etoposide, and ifosfamide followed by autologous stem-cell transplantation in relapsed or refractory germ cell cancer: a phase I/II study. The German Testicular Cancer Cooperative Study Group. (7911158)
1994
48
No germline TP53 mutations detected in familial and bilateral testicular cancer. (7680893)
1993
49
Early clinical stages (CS1, CS1Mk+ and CS2A) of non-seminomatous testis cancer. Value of pre- and post-orchiectomy serum tumor marker information in prediction of retroperitoneal lymph node metastases. Swedish-Norwegian Testicular Cancer Project (SWENOTECA). (1702312)
1990
50
A case of complete remission obtained with etoposide cis-platinum combination chemotherapy in advanced testicular cancer]. (1689134)
1990

Variations for Testicular Cancer

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Expression for genes affiliated with Testicular Cancer

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Testicular Cancer

Search GEO for disease gene expression data for Testicular Cancer.

Pathways for genes affiliated with Testicular Cancer

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database
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Pathways related to Testicular Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3CGB5, CGA, CGB

Compounds for genes affiliated with Testicular Cancer

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB
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Compounds related to Testicular Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
111-ketotestosterone4510.0CGB5, CGA
2organon4510.0CGB5, CGA
3thyroxine45 2411.0AFP, CGB, CGA
4trilostane45 1111.0CGB5, CGA
5estradiol benzoate4510.0CGB5, CGA
617-hydroxypregnenolone4510.0CGA, CGB5
7leuprolide45 61 29 1113.0CGA, CGB5
8dihydroprogesterone4510.0CGA, CGB5
9cetrorelix45 29 1111.9CGA, CGB5
108-bromo-cyclic amp459.9CGA, CGB5
1122r-hydroxycholesterol45 2910.9CGA, CGB5
12buserelin45 29 1111.9CGB5, CGA
13leuprolide acetate459.9CGB5, CGA
14lutein459.9CGB5, CGA
15(+-)-pgf2-alpha459.8CGA, CGB5
1625-hydroxycholesterol45 29 2411.8CGA, CGB5
17percoll459.8CGA, CGB5
18vinblastine45 51 1111.7AFP, CGA, CGB5
1917-hydroxyprogesterone45 2410.7CGA, CGB5
20ctp459.7CGB5, CGA, CGB
21androstenedione45 2410.7CGB5, CGA, CGB
22vincristine45 51 1111.7AFP, CGB, CGB5
233beta-hydroxysteroid459.7INSL3, CGA, CGB5
24folate459.6CGB5, CGA, AFP
25dmso459.6CGB5, CGA, AFP
26naloxone45 29 51 1112.6CGB5, CGA
27gnrh459.5CGB5, CGA, CGB
28oestriol459.5CGB5, CGA, CGB, AFP
29clomiphene citrate459.5AFP, CGB, CGA, CGB5
30ifosfamide45 1110.5AFP, CGB, CGA, CGB5
31bleomycin45 1110.5AFP, CGB, CGA, CGB5
32mifepristone45 29 61 1112.5AFP, CGB, CGA, CGB5
33cyclophosphamide45 51 1111.5AFP, CGB, CGA, CGB5
34methotrexate51 45 1111.5CGB5, CGA, CGB, AFP
35diethylstilbestrol45 29 1111.5CGB5, CGA, AFP, INSL3
36etoposide45 51 61 1112.5CGB5, CGA, CGB, AFP
37epinephrine45 24 1111.4CGB5, CGA, AFP
38estradiol45 24 1111.4AFP, CGB, CGA, CGB5
39lactate459.4AFP, CGB, CGA, CGB5
40cisplatin45 51 61 1112.4CGB5, CGA, CGB, AFP
41creatinine459.4CGB5, CGA, CGB, AFP
42alanine459.3INSL3, AFP, CGB, CGA
43progesterone45 29 61 24 1113.3AFP, CGB, CGA, CGB5
44nitrate459.3CGB5, AFP
45cyclic amp45 2410.3INSL3, CGB, CGA, CGB5
46steroid459.2CGB5, CGA, AFP, INSL3
47testosterone45 61 24 1112.1INSL3, AFP, CGB, CGA, CGB5
48ethanol45 51 24 1112.1CGB5, ACPT, AFP
49estrogen459.1CGB5, CGA, CGB, AFP, INSL3
50vegf459.1AFP, CGB, CGA, CGB5

GO Terms for genes affiliated with Testicular Cancer

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16Gene Ontology
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Biological processes related to Testicular Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.6CGA, CGB
2cell-cell signalingGO:0072679.6CGA, CGB, INSL3

Molecular functions related to Testicular Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6CGA, CGB, INSL3

Products for genes affiliated with Testicular Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Testicular Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet