MCID: TST014
MIFTS: 58

Testicular Cancer malady

Cancer diseases, Reproductive diseases categories

Summaries for Testicular Cancer

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Sources:
33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Testicles, or testes, make male hormones and sperm. they are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. you can get cancer in one or both testicles. testicular cancer mainly affects young men between the ages of 20 and 39. it is also more common in men who have had abnormal testicle development have had an undescended testicle have a family history of the cancer symptoms include pain, swelling, or lumps in your testicles or groin area. doctors use a physical exam, lab tests, imaging tests, and a biopsy to diagnose testicular cancer. most cases can be treated, especially if found early. treatment options include surgery, radiation, and/or chemotherapy. regular exams after treatment are important. treatments may also cause infertility. if you may want children later on, you should consider sperm banking before treatment. nih: national cancer institute

MalaCards: Testicular Cancer, also known as malignant neoplasm of testis, is related to cryptorchidism and seminoma. An important gene associated with Testicular Cancer is AFP (alpha-fetoprotein), and among its related pathways is Glycoprotein hormones. The drugs cyclophosphamide and cisplatin and the compounds oestriol and clomiphene citrate have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and lymph node.

Wikipedia:63 Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system. more...

Description from OMIM:46 273300

Aliases & Classifications for Testicular Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

testicular cancer 8 42 10 44 33
malignant neoplasm of testis 60
carcinoma of the testis 60
cancer of the testes 42
testicular carcinoma 44
testicular neoplasms 60
neoplasm of testis 8
testicular tumor 8
testis neoplasm 8
testis cancer 8


External Ids:

Disease Ontology8 DOID:2998
NCIt39 C3404
MeSH34 D013736
OMIM46 273300
ICD1025 C62

Related Diseases for Testicular Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Testicular Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1cryptorchidism30.6AZF1, CGA, CGB5
2seminoma30.5CGA, CGB5, CGB, AFP, SSX2, MAGEA1
3prostate cancer30.5CTAG1B, CGB, XAGE1D
4lung cancer30.4CCNA1, CTAG1B, CGB, MAGEA3, MAGEA1, MAGEA4
5infertility30.4AZF1, CGA, CGB, TRO
6male germ cell tumor, somatic30.4CGA, AFP
7breast cancer30.3CCNA1, CTAG1B, CGB, SSX2, MAGEA3, MAGEA1
8embryonal cancer30.2CGA, CGB5, CGB, AFP
9gynecomastia30.1CGA, CGB5
10leukemia30.1CCNA1, CTAG1B, CGB, MAGEA3, MAGEA1
11choriocarcinoma30.1CGA, CGB5, CGB, AFP
12ovarian cancer29.9CTAG1B, CGB5, CGB, PRSS21, AFP, SSX2
13sarcoma29.9CTAG1B, CGB5, CGB, SSX2, MAGEA3, MAGEA1
14oligospermia29.9CGB5, CGA, AZF1
15leydig cell tumor29.9CGB5, CGA
16azoospermia29.9AZF1, CGA, CGB5
17colorectal cancer29.9MAGEA1, MAGEA3, CGB
18klinefelter's syndrome29.9AZF1, CGA, CGB
19endodermal sinus tumor29.9AFP
20retroperitoneal cancer10.7
21lymph node cancer10.7
22testicular disease10.5
23vascular cancer10.4
24embryonal testis carcinoma10.3
25encephalitis10.3
26prostatitis10.3
27sarcoidosis10.3
28dermatomyositis10.2
29kidney cancer10.2
30congenital adrenal hyperplasia10.2
31rete testis neoplasm10.2
32testicular lymphoma10.2
33brain cancer10.2
34heart cancer10.2
35hypogonadism10.2
36kidney disease10.2
37mature teratoma10.2
38pituitary cancer10.2
39polyarteritis nodosa10.1
40hypercalcemia10.1
41astrocytoma10.1
42malignant leydig cell tumor10.1
43mixed germ cell cancer10.1
44acute leukemia10.1
45hyperthyroidism10.1
46adenomatoid tumor10.1
47adrenal carcinoma10.1
48male breast cancer10.1
49testicular leukemia10.1
50testicular infarct10.1

Graphical network of the top 20 diseases related to Testicular Cancer:



Diseases related to testicular cancer

Clinical Features for Testicular Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

273300

Drugs & Therapeutics for Testicular Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Testicular Cancer

Drug clinical trials:

Search ClinicalTrials for Testicular Cancer

Search NIH Clinical Center for Testicular Cancer

Search CenterWatch for Testicular Cancer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Testicular Cancer

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Anatomical Context for Testicular Cancer

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Sources:
32MalaCards
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MalaCards organs/tissues related to Testicular Cancer:

32
Testis, Testes, Lymph node, Skin, Prostate, Lung, Breast, Kidney, Pituitary, Heart, Brain, Liver, Colon, Bone, Spleen, Myeloid, B cells, Endothelial, Pineal

Animal Models for Testicular Cancer or affiliated genes

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Publications for Testicular Cancer

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Sources:
50PubMed
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Articles related to Testicular Cancer:

(show top 50)    (show all 771)
idTitleAuthorsYear
1
Bilateral germ-cell testicular cancer - long-term experience. (24320591)
2013
2
Lifetime growth and risk of testicular cancer. (24375202)
2013
3
Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept. (23784825)
2013
4
Effects of antioxidants on drugs used against testicular cancer-induced alterations in metastasis-associated protein 1 signaling in the rat testis. (24021429)
2013
5
Study of expression of testicular cancer genes in breast cancer samples. (24385105)
2013
6
Re: Residual tumor size and IGCCCG risk classification predict additional vascular procedures in patients with germ cell tumors and residual tumor resection: a multicenter analysis of the German Testicular Cancer Study Group. (23235218)
2013
7
Gastric Metastases From Testicular Cancer: Case Report and Review of Literature. (23872940)
2013
8
Tuberculosis of testis and prostate that mimicked testicular cancer in young male soccer player. (24278889)
2013
9
Pro- and anti-apoptotic effects of p53 in cisplatin-treated human testicular cancer are cell context-dependent. (23165211)
2012
10
The role of residual tumor resection in the management of nonseminomatous germ cell cancer of testicular origin. (22383152)
2012
11
Re: Public perceptions of the harms and benefits of testicular cancer education: a qualitative study. (22153431)
2012
12
Testicular cancer: our experience after 10 years. (22619138)
2012
13
The role of imaging in staging and monitoring testicular cancer. (22464993)
2012
14
Time trends in testicular cancer in Croatia 1983-2007: rapid increases in incidence, no declines in mortality. (22014475)
2012
15
Testicular microlithiasis: analysis of prevalence and associated testicular cancer in central-eastern Sicilian andrological patients. (21729139)
2012
16
The semen quality of 1158 men with testicular cancer at the time of cryopreservation: results of the French National CECOS Network. (22837112)
2012
17
Adolescent and adult risk factors for testicular cancer. (22508459)
2012
18
Testicular cancer: a narrative review of the role of socioeconomic position from risk to survivorship. (22127018)
2012
19
The clinical utility of testicular cancer risk loci. (21255381)
2011
20
Perceptions of masculinity and self-image in adolescent and young adult testicular cancer survivors: implications for romantic and sexual relationships. (20878864)
2011
21
Shedding light on testicular cancer. (21685776)
2011
22
Lipophilic Pt(II) complexes with selective efficacy against cisplatin-resistant testicular cancer cells. (22071088)
2011
23
The predictive value of testicular ultrasound abnormalities for carcinoma in situ of the testis in men at risk for testicular cancer. (19845800)
2010
24
Long-term neurologic and peripheral vascular toxicity after chemotherapy treatment of testicular cancer. (20225230)
2010
25
Sexual function, depressive symptoms and marital status in nonseminoma testicular cancer patients: a longitudinal study. (19319832)
2010
26
A novel approach to estimate the German-wide incidence of testicular cancer. (20117067)
2010
27
Fertility among testicular cancer survivors: a case-control study in the U.S. (20571931)
2010
28
Risk of contralateral testicular cancer among men with unilaterally undescended testis: a meta analysis. (18973229)
2009
29
Physical activity in adolescence and testicular germ cell cancer risk. (19399630)
2009
30
Seminal expression of NY-ESO-1 and MAGE-A4 as markers for the testicular cancer. (19207618)
2009
31
Ma-2 paraneoplastic encephalitis in the presence of bilateral testicular cancer: diagnostic and therapeutic approach. (19597017)
2009
32
Long-term follow-up of testicular cancer patients shows no predisposition to osteoporosis. (19030945)
2009
33
Risk of cancer in first- and second-degree relatives of testicular germ cell tumor cases and controls. (19035442)
2009
34
Laparoscopic retroperitoneal lymph node dissection for low-stage testicular cancer. (18613781)
2008
35
Medical treatment of advanced testicular cancer. (18270356)
2008
36
Duplicated inferior vena cava (IVC) in a patient with testicular cancer. (17991567)
2007
37
Sperm cryopreservation: recent and marked increase in use for testicular cancer compared with Hodgkin disease. (17609293)
2007
38
Metastatic colon cancer to the testicle presenting as testicular hydrocele. (16051969)
2005
39
Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. (15269155)
2004
40
Multiple relapses of mature teratoma, germinal and non-germ cell cancer in a patient treated with chemotherapy for testicular non-seminomatous germ cell cancer. (12801050)
2003
41
Activity of oxaliplatin in patients with relapsed or cisplatin-refractory germ cell cancer: a study of the German Testicular Cancer Study Group. (11956262)
2002
42
MRP expression of testicular cancers and its clinical relevance. (11268495)
2000
43
Dermatomyositis associated with testicular germ cell cancer. (10604362)
2000
44
The clinical value of mdm-2 (proto-oncogene) expression in testicular cancer, Correlation with tumor progression]. (10489783)
1999
45
Diagnosis and treatment of patients with testicular germ cell cancer. (10473019)
1999
46
Serum alpha-fetoprotein surge after the initiation of chemotherapy for non-seminomatous testicular cancer has an adverse prognostic significance. (9823978)
1998
47
CT detection of retroperitoneal lymph node metastases in patients with clinical stage I testicular nonseminomatous germ cell cancer: assessment of size and distribution criteria. (9242768)
1997
48
Dose-dependent impairment of testicular function in patients treated with cisplatin-based chemotherapy for germ cell cancer. (8075033)
1994
49
Paternity in patients with testicular germ cell cancer: pretreatment and post-treatment findings. (1835852)
1991
50
Prostate cancer in a 75-year-old man after four decades of testicular androgen deprivation. (1743239)
1991

Genetic Variations for Testicular Cancer

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Expression for genes affiliated with Testicular Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Testicular Cancer

Search GEO for disease gene expression data for Testicular Cancer.

Pathways for genes affiliated with Testicular Cancer

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Sources:
53Reactome
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Pathways related to Testicular Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6CGB, CGA

Compounds for genes affiliated with Testicular Cancer

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Testicular Cancer according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1oestriol4411.0AFP, CGB, CGB5, CGA
2clomiphene citrate4411.0CGA, CGB5, CGB, AFP
3ifosfamide44 1112.0AFP, CGB, CGB5, CGA
4bleomycin44 1112.0CGA, CGB5, CGB, AFP
5paraffin4411.0CGA, CGB5, AFP, MAGEA3, MAGEA1
6mifepristone44 59 28 1114.0CGA, CGB5, CGB, AFP
7cyclophosphamide44 49 1113.0AFP, CGB, CGB5, CGA
8ctp4411.0CGB, CGB5, CGA
9methotrexate44 49 1113.0CGA, CGB5, CGB, AFP
105-aza-2deoxycytidine4410.9CTAG1B, SSX2, BAGE, MAGEA1
11etoposide44 49 59 1113.9CGA, CGB5, CGB, AFP
12diethylstilbestrol44 28 1112.9AFP, CGB5, CGA
1311-ketotestosterone4410.9CGA, CGB5
14vinblastine44 49 1112.9AFP, CGB5, CGA
15organon4410.9CGA, CGB5
16androstenedione44 2411.9CGB, CGB5, CGA
17trilostane44 1111.8CGB5, CGA
18estradiol benzoate4410.8CGA, CGB5
1917-hydroxypregnenolone4410.8CGA, CGB5
20leuprolide44 59 28 1113.8CGA, CGB5
21dihydroprogesterone4410.8CGB5, CGA
22cetrorelix44 28 1112.8CGA, CGB5
23vincristine44 49 1112.7AFP, CGB, CGB5
248-bromo-cyclic amp4410.7CGA, CGB5
2522r-hydroxycholesterol44 2811.7CGA, CGB5
26vegf4410.7AFP, CGB, CGB5, CGA, CCNA1
27leuprolide acetate4410.6CGB5, CGA
28buserelin44 28 1112.6CGB5, CGA
29estradiol44 11 2412.5CGA, CGB5, CGB, AFP
30lutein4410.2CGB5, CGA

GO Terms for genes affiliated with Testicular Cancer

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16Gene Ontology
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Biological processes related to Testicular Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:01648610.6CGB, CGA

Products for genes affiliated with Testicular Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Testicular Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet