Search MalaCards:
MCID: TST014

Testicular Cancer malady
34 drugs, 144 genes, 9 tissues, 1463 related diseases, 27 phenotypes, 107 articles, clinical trials.

Summaries for Testicular Cancer

about this section
Sources:
23MedlinePlus, 44Wikipedia, 22MalaCards
See all sources

Export this MalaCard
MedlinePlus: Testicular cancer forms in a man's testicles, the two egg-shaped glands that produce sperm and testosterone. testicular cancer mainly affects young men between the ages of 20 and 39. it is also more common in men who have had abnormal testicle development have had an undescended testicle have a family history of the cancer symptoms include pain, swelling or lumps in your testicles or groin area. most cases can be treated, especially if it is found early. treatment options include surgery, radiation and/or chemotherapy. regular exams after treatment are important. treatments may also cause infertility. if you may want children later on, you should consider sperm banking before treatment. nih: national cancer institute23

MalaCards: Testicular Cancer, also known as testis cancer, is related to adrenal hyperplasia and brain cancer. An important gene associated with Testicular Cancer is ACPT (acid phosphatase, testicular), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Glioma Invasiveness. The drugs prednisone and prednisolone tebutate and the compounds cyclophosphamide and threonine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and liver, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia: Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system.44 more...

Aliases & Descriptions for Testicular Cancer

about this section
Sources:
6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 32Novoseek , 23MedlinePlus, 2CDC, 43UMLS, 40SNOMED-CT, 33OMIM, 24MeSH, 27NCIt
See all sources

Aliases & Descriptions:

testicular cancer 6 30 32 23
testis cancer 6 8
neoplasm of testis (disorder) 6
malignant neoplasm of testis 43
testicular tumor (disorder) 6
testicular neoplasms 43
cancer of the testes 30
testicular tumor 6
testis neoplasm 6
neoplasms 43

Related Diseases for Testicular Cancer

about this section
Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to testicular cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1460)
idRelated DiseaseScoreTop Affiliating Genes
1adrenal hyperplasia31.0CGA, CGB, CGB5, AR, IGFBP3, IGF1
2brain cancer30.9MGMT, MDM2, GHRH, EGF
3ovarian cancer30.7FSHR, CDKN1A, CDKN2C, CDKN1B, CCNA2, CCND2
4colonic neoplasm30.7CDKN1A, CDH1, TP53, CTNNA1
5cryptorchidism30.2USP9Y, CGA, CGB5, AZF1, AR, INSL3
6skin benign neoplasm30.1XPC, MGMT, ALOX12, HPRT1, ERCC2, TYR
7gestational trophoblastic neoplasm30.1CGA, CGB, CGB5, ALPP, TERC, H19
8mature teratoma29.8CGA, CGB, ALPP, AFP
9testicular neoplasm29.8INSL3, ALPP, ALPPL2, STK11, AFP
10tongue cancer29.8CDKN1A, CDH1, MMP2, MMP9, MKI67, FAS
11hepatitis29.8FAS, CYP1A2, PDGFB, KRT18, DNMT1, AFP
12pancreatic cancer29.8RAC1, CDKN1A, MGMT, CASP3, GHRH, RHOA
13endodermal sinus tumor29.7CGB, CGB5, ALPP, ALPPL2, AFP
14intestinal neoplasm29.6BMP6, MMP2, MMP9, KRAS
15hydrocele29.6CGA, CGB5, FLT4, AFP
16oral cavity cancer29.5NAT2, GSTM1, GSTT1, CASP8, TP53
17nasopharynx carcinoma29.4NAT2, VEGFC, CDH1, GSTM1, GSTT1, MDM2
18parathyroid carcinoma29.4CGB5, MKI67, CASR, TP53
19breast cancer29.3BMP6, CDKN1B, CDH1, AR, FGF4, CCND3
20salivary gland cancer29.2MMP9, AR, FAS, CASP3, CASP8, PPARG
21hypospadias29.2CGA, AR, INSL3, GSTM1, GSTT1, RXFP2
22carney complex29.2MLANA, FGF2, TYR, TYRP1, PMEL
23basal cell carcinoma29.1LGALS1, MKI67, GSTM1, GSTT1, ERCC2, ERCC1
2421-hydroxylase deficiency28.9CGB5, AR, IGFBP3, ALPP, GNRH1, GH1
25ovarian mucinous neoplasm28.7MSX2, CDKN1A, CDH1, MMP9, MKI67, GSTP1
26ocular cancer28.7VEGFC, CASP3, RHOA
27placental site trophoblastic tumor28.6CGA, CGB, CGB5
28thoracic cancer28.6CDKN1A, CASP3, CASP8, CASP9
29squamous cell carcinoma28.2LGALS1, CDH1, MKI67, GSTP1, CCNA2, EGF
30teratoma28.1CGA, CGB, CGB5, CDH1, ENO2, IFI27
31leydig cell tumor28.0LGALS1, CGA, CGB, CGB5, FSHR, INSL3
32gestational trophoblastic tumor27.9CGA, CGB, CGB5, H19
33angiomyolipoma27.9MLANA, AR, IL6, ALPP, TP53, TYR
34hodgkin's lymphoma27.8LGALS1, ATM, CDKN2C, IL2RA, IL3, MDM2
35xeroderma pigmentosum27.8XPC, ATM, MGMT, GSTT1, FAS, HPRT1
36bronchogenic carcinoma27.6CGB, CGB5, CDKN1A, IL3, MDM2, ENO2
37pituitary tumor27.2FSHR, CDKN1B, FGF2, FGF4, IGF1, IFI27
38synovial sarcoma27.1CDH1, MKI67, MDM2, MAGEA1, SSX2, CTAG1B
39cardia cancer27.0GSTM1, GSTP1, GSTT1, MDM2, TP53
40chromophobe renal cell carcinoma27.0MAGEA3, MAGEA4, CTAG1B, KRT18, EGF, CSF2
41encephalitis26.9BMP6, B2M, IL6, ENO2, ALOX5, CASP3
42lynch syndrome26.9MGMT, GSTM1, GSTP1, GSTT1, MDM2, FAS
43lung benign neoplasm26.9LGALS1, MVP, XPC, MGMT, GSTP1, MDM2
44pancreatic ductal carcinoma26.9MMP9, ALOX5, TP53, WT1, EGF
45hematologic cancer26.7ATM, CDKN1B, IL2RA, IL3, MAGEA3, MAGEA1
46angiosarcoma26.7VEGFC, FLT4, MDM2, ALPPL2, TP53, KRT18
47dermatomyositis26.7BMP6, CGB, IL2RA, IL6, FAS, ALOX5
48hypogonadism26.6SERPINE1, CGA, CGB5, FSHR, AR, IL6
49malignant sertoli cell tumor26.5CGB5, ALPP, AFP
50sertoli cell tumor26.4CGB, CGB5, MLANA, AR, ENO2, ALPP

Graphical network of the top 20 diseases related to testicular cancer:



Graphical network of diseases related to testicular cancer

Clinical Features for Testicular Cancer

about this section

Drugs & Therapeutics for Testicular Cancer

about this section
Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for testicular cancer

Drug clinical trials:

Search ClinicalTrials for testicular cancer

Search NIH Clinical Center for testicular cancer

Search CenterWatch for testicular cancer

Inferred drug relations via UMLS/NDF-RT:

43 28 bleomycin, bleomycin sulfate, chlorambucil, cisplatin, cisplatin pwdr [va product], cyclophosphamide, dactinomycin, dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], doxorubicin hydrochloride, etoposide, etoposide phosphate, ifosfamide, linolenic acid, methotrexate, methotrexate sodium, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, plicamycin, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product], vinblastine, vinblastine sulfate

Genetic Tests for Testicular Cancer

about this section

Anatomical Context for Testicular Cancer

about this section
Sources:
22MalaCards
See all sources

MalaCards organs/tissues related to testicular cancer:

22
Lymph node, Brain, Liver, Lung, Prostate, Testis, Endothelial, Pituitary, Testis germ

Phenotypes for genes affiliated with Testicular Cancer

about this section
Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to testicular cancer:

25 (show all 27)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.5PDGFB, RXFP2, HPRT1, RAI1
2endocrine/exocrine gland phenotypeMP:00053799.9CYP1A2, CDKN1B, CDKN2C, FSHR, MSX2, SERPINE2
3embryogenesis phenotypeMP:00053809.7H19, HDAC1, MYB, CASP9, ALPP, IGF2BP1
4craniofacial phenotypeMP:00053829.6STK11, CSF2, EMX2, HDAC1, H19, TYRP1
5liver/biliary system phenotypeMP:00053709.2H19, MYB, AR, IL6, CYP1A2, PTN
6limbs/digits/tail phenotypeMP:00053719.1IGF2BP1, HOXA9, TERC, CTNNA1, NRAS, KRAS
7no phenotypic analysisMP:00030128.9PPARG, PDGFB, TYR, DNMT1, STK11, PMEL
8pigmentation phenotypeMP:00011868.9TP53, TERC, PDGFB, KRAS, TYR, TYRP1
9renal/urinary system phenotypeMP:00053678.7CASP3, GNRH1, IGF2BP1, GPRC6A, AR, CDKN1B
10normal phenotypeMP:00028738.3GNRH1, TRO, NRAS, WT1, KRAS, TYR
11hematopoietic system phenotypeMP:00053977.9MDM2, IL3, FGF2, INCA1, CDKN2C, CDKN1A
12reproductive system phenotypeMP:00053897.7AFP, EMX2, CSF2, PRKG1, PRSS21, STK11
13nervous system phenotypeMP:00036317.6H19, RUNX3, PRKG1, STK11, DNMT1, TYRP1
14behavior/neurological phenotypeMP:00053867.2STK11, LOX, IGF2BP1, CCND3, CCND2, ENO2
15immune system phenotypeMP:00053877.2CDKN2C, FSHR, ATM, MSX2, XIST, LGALS1
16integument phenotypeMP:00107717.0CSF3, TERC, TP53, ERCC1, ERCC2, HOXA9
17digestive/alimentary phenotypeMP:00053817.0HPRT1, TERC, NRAS, KRAS, EGF, DNMT1
18adipose tissue phenotypeMP:00053756.6GH1, ERCC2, ERCC1, TP53, TERC, PTTG1
19mortality/agingMP:00107686.1TYRP1, HPRT1, CASR, CASP2, CASP7, LOX
20vision/eye phenotypeMP:00053916.0PDGFB, NRAS, PPARG, PPP1R13L, TERC, TP53
21skeleton phenotypeMP:00053905.8PDGFA, RXFP2, PPARG, CTNNA1, TERC, TP53
22muscle phenotypeMP:00053695.3CDKN1B, CDKN1A, MSX2, LGALS1, RAC1, RELA
23tumorigenesisMP:00020065.2AFP, H19, CSF2, TERC, TP53, ERCC1
24growth/size phenotypeMP:00053784.1RAC1, RAI1, BMP6, MYB, NAGLU, SERPINE1
25cellular phenotypeMP:00053843.8EMX2, RUNX3, CSF2, CXADR, STK11, DNMT1
26cardiovascular system phenotypeMP:00053853.4WT1, CASP8, CASP3, CASP7, ALOX5, LOX
27homeostasis/metabolism phenotypeMP:00053762.4PMEL, CSF2, CXADR, PRKG1, STK11, DNMT1

Publications for genes affiliated with Testicular Cancer

about this section
Sources:
35PubMed
See all sources

Articles related to testicular cancer:

(show top 50)    (show all 107)
idTitleAuthorsYearAffiliating Genes
1Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. (21489989)Mao P.... Spinella M.J.2011TP53, STK17A
2Association of PAI-1 gene polymorphism with survival and chemotherapy-related vascular toxicity in testicular cancer. (20737565)de Haas E.C.... Gietema J.A.2010SERPINE1
3Levels of circulating interleukin-1 receptor antagoni st and C-reactive protein in long-term survivors of testicular cancer with chro nic cancer-related fatigue. (19362138)Orre I.J.... FossAY S.D.2009IL6
4On combining triads and unrelated subjects data in candidate gene studies: an application to data on testicular cancer. (19077426)Hsu L.... Schwartz S.M.2009IGF1, IGFBP3, CYP3A4
5Estrogen receptor-binding fragment-associated gene 9 expression and its clinical significance in human testicular cancer. (19207611)Fujimura T.... Inoue S.2009EBAG9
6Seminal expression of NY-ESO-1 and MAGE-A4 as markers for the testicular cancer. (19207618)Satie A.P.... JAcgou B.2009MAGEA4, CTAG1B
7Endogenous steroid hormone levels in early pregnancy and risk of testicular cancer in the offspring: a nested case-referent study. (19330837)Holl K.... Lukanova A.2009SHBG
8Free beta-subunit of human chorionic gonadotropin in serum is a diagnostically sensitive marker of seminomatous testicular cancer. (18787014)LempiAoinen A.... Hotakainen K.2008CGB5
9Y chromosome haplogroups and susceptibility to testicular cancer. (17682003)Ferlin A.... Foresta C.2007USP9Y, AZF1
10DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer. (16960727)Omisanjo O.A.... Steger K.2007DNMT1, HDAC1
11Significance of thcg assay in the management of testicular cancer--the possibility of a standard assay in testicular cancer as an alternative to FbetahCG assay (17302291)Takizawa A.... Kubota Y.2007CGB5
12Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study. (18162130)Oldenburg J.... Fossa S.D.2007GSTP1, GSTT1, GSTM1
13Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1). (17029216)Lind G.E.... Lothe R.A.2006RUNX3, MSX2, EMX2
14Predictors of outcome in patients undergoing postchemotherapy retroperitoneal lymph node dissection for testicular cancer. (16944541)Spiess P.E.... Pisters L.L.2006CGB5
15Y chromosome instability in testicular cancer. (16483836)Bianchi N.O.... Pavicic W.2006AZF1
16Immunostaining for placental alkaline phosphatase on fine-needle aspiration specimens to detect noninvasive testicular cancer: a prospective evaluation in cryptorchid men. (16643476)Tavolini I.M.... Foresta C.2006ALPP
17Molecular analysis of the androgen receptor gene in testicular cancer. (16172197)Garolla A.... Foresta C.2005AR
18ATM activation in normal human tissues and testicular cancer. (15846060)Bartkova J.... Bartek J.2005ATM, H2AFX
19Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer. (15885892)Laska M.J.... Vogel U.2005ERCC2, RELA, ERCC1
20XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer. (14723995)Kawakami T.... Okada Y.2004XIST
21Clinical parameters that predict histology of postchemotherapy retroperitoneal lymph node mass in testicular cancer. (15242364)Onozawa M.... Akaza H.2004AFP
22Ethnic variation in the prevalence of AZF deletions in testicular cancer. (15450403)Richard S.M.... Pavicic W.2004AZF1
23Calcium-sensing receptor induces messenger ribonucleic acid of human securin, pituitary tumor transforming gene, in rat testicular cancer. (12970167)Tfelt-Hansen J.... Chattopadhyay N.2003CASR, CXADR, PTTG1
24Marked increase of the growth factors pleiotrophin and fibroblast growth factor-2 in serum of testicular cancer patients. (14504053)Aigner A.... Zugmaier G.2003EGF, FGF2, FGF4
25Neuron-specific enolase in testicular cancer--clinical experiences with serum neuron-specific enolase in patients with testicular cancer at diagnosis and during follow-up. (12852696)Tandstad T.... Klepp O.2003ENO2
26Combined analysis of tumor growth pattern and express ion of endogenous lectins as a prognostic tool in primary testicular cancer and its lung metastases. (12792889)Kayser K.... Gabius H.J.2003LGALS1
27alpha-Catenin expression pattern and DNA image-analysis cytometry have no additional value over primary histology in clinical stage I nonseminomatous testicular cancer. (11856111)Spermon J.R.... van Moorselaar R.J.2002CTNNA1
28Routine chest X-rays have no additional value in the detection of relapse during routine follow-up of patients treated with chemotherapy for disseminated non-seminomatous testicular cancer. (12377651)Gietema J.A.... van der Graaf W.T.2002CGB
29Expression of peroxisome proliferator-activated receptors in human testicular cancer and growth inhibition by its agonists. (12350514)Hase T.... Sano H.2002PPARG
30PET and PLAP in suspected testicular cancer relapse: beware sarcoidosis. (11762823)Karapetis C.S.... Harper P.G.2001ALPP
31Cell cycle regulators in testicular cancer: loss of p18INK4C marks progression from carcinoma in situ to invasive germ cell tumours. (10652429)Bartkova J.... Bartek J.2000CCNA2, CDKN1B, CDKN1A
32False-negative biopsy for testicular intraepithelial neoplasia and high-risk features for testicular cancer. (10752663)Cappelen T.... Aass N.2000ALPPL2
33Correlation between expression of metastasis-related genes and lymph node metastasis in testicular cancer (11215209)Koshida K.... Namiki M.2000FLT4, CDH1, MMP16
34125I-labelled human chorionic gonadotrophin (hCG) as an elimination marker in the evaluation of hCG decline during chemotherapy in patients with testicular cancer. (10408402)Christensen T.B.... von der Maase H.1999CGA
35A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer. (10362822)Voltz R.... Dalmau J.1999PNMA2
36Molecular staging of testicular cancer using polymerase chain reaction of the testicular cancer-specific genes (10500969)Nonomura N.... Okuyama A.1999CGB
37Serum alpha-fetoprotein surge after the initiation of chemotherapy for non-seminomatous testicular cancer has an adverse prognostic significance. (9823978)de Wit R.... Stoter G.1998CGA, AFP
38Validity of predictions of residual retroperitoneal mass histology in nonseminomatous testicular cancer. (9440752)Steyerberg E.W.... Keizer H.J.1998AFP, CGB5
39Hematopoietic growth factors and treatment of testicular cancer: biological interactions, routine use and dose-intensive chemotherapy. (8605273)Bokemeyer C.... Schmoll H.J.1996CSF3
40Resection of residual retroperitoneal masses in testicular cancer: evaluation and improvement of selection criteria. The ReHiT study group. Re-analysis of histology in testicular cancer. (8912551)Steyerberg E.W.... Habbema J.D.1996AFP, CGB5
41A study of topoisomerase activity in human testicular cancers. (8572612)Sano K.... Shuhin T.1995TOP1
42The role of granulocyte-macrophage colony-stimulating factor in the treatment of germ cell tumors. German Testicular Cancer Study Group. (7801148)Bokemeyer C.... Schmoll H.J.1994IL3
43Urinary endothelin-1-like immunoreactivity in young m ale patients with testicular cancer treated by cis-platinum: comparison with ot her urinary parameters. (7520380)Takeda M.... Tanikawa T.1994B2M
44No germline TP53 mutations detected in familial and bilateral testicular cancer. (7680893)Heimdal K.... rresen A.L.1993TP53
45Free alpha-subunit, free beta-subunit of human chorionic gonadotropin (hCG), and intact hCG in sera of healthy individuals and testicular cancer patients. (1372196)Madersbacher S.... Berger P.1992CGB5
46Prognostic factors in unselected patients with nonseminomatous metastatic testicular cancer: a multicenter experience. (1707957)Aass N.... FossAY S.D.1991CGA, AFP
47Tumor markers in testicular cancer (2158684)Mann K.1990AFP, CGB5
48Increased growth hormone responses to growth hormone releasing hormone and thyrotropin releasing hormone in patients with metastatic testicular cancer. (2108920)Pietschmann P.... Schernthaner G.1990GHRH
49Prognosis in patients with metastatic non-seminomatous testicular cancer. (1693003)Aass N.... Kaalhus O.1990AFP
50Testicular cancer secretes intact human choriogonadotropin (hCG) and its free beta-subunit: evidence that hCG (+hCG-beta) assays are the most reliable in diagnosis and follow-up. (1689221)Saller B.... Mann K.1990CGA

Expression for genes affiliated with Testicular Cancer

about this section
Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Testicular Cancer

Pathways for genes affiliated with Testicular Cancer

about this section
Sources:
36QIAGEN, 20KEGG
See all sources

Pathways related to testicular cancer according to GeneDecks:

(show top 50)    (show all 138)
idPathwayScoreTop Affiliating Genes
1Actin-Based Motility by Rho Family GTPases3610.0FGF4, IGF1, GH1, GHRH
2Glioma Invasiveness369.6VEGFC, BMP6, IL3, FGF4, FGF2, NRAS
3Breast Cancer Regulation by Stathmin1369.5CDC42, RAC1, FGF2, FGF4, GHRH, EGF
4G1-S Phase Transition369.5TP53, HDAC1, ATM, CDKN2C, CDKN1A, CCNA1
5Akt Signaling369.4CASP9, HSP90AA1, CCND3, CCND2, MDM2, IL6
6Glioblastoma Multiforme369.2MDM2, NRAS, TP53, MGMT, CDC42, RAC1
7Cyclins and Cell Cycle Regulation369.2CDKN1B, CCNA2, CDKN2C, CCND3, CCNA1, TP53
8ERK5 Signaling369.2NRAS, PDGFA, PDGFB, VEGFC, PTN, GHRH
9Ras Pathway369.1GNRH1, GHRH, NRAS, VEGFC, CDC42, PDGFA
10eNOS Signaling369.1CASP3, CASP8, GH1, GHRH, PTN, PDGFA
1114-3-3 Induced Intracellular Signaling368.9GNRH1, FGF2, PDGFB, NRAS, PTN, GHRH
12Telomerase Components in Cell Signaling368.4VEGFC, BMP6, ATM, FLT4, FGF2, FGF4
13PPAR Pathway368.3PDGFB, NRAS, VEGFC, FLT4, FGF2, FGF4
14Paxillin Interactions368.2GHRH, PTN, PDGFA, PDGFB, CDC42, GH1
15Renin-Angiotensin Pathway368.1IL6, IGF1, GNRH1, NRAS, GH1, GHRH
16PTEN Pathway368.1EGF, TP53, PTN, PDGFB, PDGFA, NRAS
17JNK Pathway367.9FGF4, IL2RA, IL3, IL6, GHRH, TP53
18Bladder cancer207.8VEGFC, CDKN1A, MDM2, CDH1, MMP2, TP53
19Prostate cancer207.7CASP9, HSP90AA1, IGF1, MDM2, GSTP1, RELA
20Melanoma207.7MDM2, FGF4, FGF2, CDH1, TP53, CDKN1A
21ILK Signaling367.6IL3, IGF1, CASP9, GH1, GHRH, PTN
22mTOR Pathway367.6EGF, STK11, PTN, GNRH1, GH1, GHRH
23p53 signaling pathway207.6FAS, MDM2, CDKN1A, CASP8, TP53, CCND3
24NF-KappaB (p50-p65) Pathway367.6IGF1, GNRH1, RELA, VEGFC, FLT4, FGF2
25NF-KappaB Family Pathway367.5RELA, EGF, VEGFC, BMP6, FLT4, FGF2
26Nanog in Mammalian ESC Pluripotency367.5GHRH, GH1, GNRH1, IL6, IL3, FGF4
27eIF2 Pathway367.5IGF1, NRAS, PDGFA, PDGFB, EGF, GHRH
28Rac1 Pathway367.4BMP6, NRAS, PDGFA, PDGFB, FLT4, FGF2
29p70S6K Signaling367.4GNRH1, GHRH, PTN, NRAS, PDGFA, PDGFB
30Nuclear Receptor Activation by Vitamin-A367.4VEGFC, GH1, BMP6, FLT4, EGF, PDGFB
31Activation of PKC through GPCR367.4FGF4, FGF2, FLT4, RAC1, BMP6, VEGFC
32GPCR Pathway367.3FGF2, FGF4, IL3, IL6, IGF1, GNRH1
33Epithelial Adherens Junctions367.2PDGFB, EGF, VEGFC, IL3, IGF1, GNRH1
34PAK Pathway367.2GNRH1, IGF1, IL6, IL3, IL2RA, FGF4
35MAPK Family Pathway367.2GH1, IL6, GHRH, PTN, NRAS, PDGFA
36TGF-Beta Pathway367.2GHRH, PTN, NRAS, PDGFA, PDGFB, EGF
37Estrogen Pathway367.1BMP6, EGF, HDAC1, VEGFC, PDGFB, PDGFA
38Apoptotic Pathways in Synovial Fibroblasts366.9EGF, PDGFB, PDGFA, PTN, TP53, GHRH
39Phospholipase-C Pathway366.9FGF4, IGF1, IL3, IL2RA, RAC1, FLT4
40DHA Signaling366.9CASP7, CASP3, CASP2, CASP8, CASP9, GH1
41Antioxidant Action of Vitamin-C366.8FLT4, IL6, CSF2, CSF3, PDGFA, NRAS
42GSK3 Signaling366.7PDGFA, PTN, NRAS, GH1, GNRH1, EGF
43Molecular Mechanisms of Cancer366.4CASP3, GNRH1, CCND2, MDM2, IL6, IL3
44MAPK Signaling366.3VEGFC, PTN, TP53, GH1, GNRH1, IGF1
45Mitochondrial Apoptosis366.2VEGFC, BMP6, ATM, FLT4, FGF2, FGF4
46p53 Mediated Apoptosis366.2GH1, GHRH, TP53, PTN, PDGFA, PDGFB
47p38 Signaling366.1GH1, FGF4, CSF3, IL6, CASP3, GNRH1
48Cellular Apoptosis Pathway366.1CASP3, CASP7, GNRH1, IGF1, MDM2, IL6
49Pathways in cancer206.1CASP8, RELA, CASP3, CCNA1, FAS, MDM2
50Pancreatic Adenocarcinoma365.7CDC42, MMP2, MMP9, FLT4, FGF2, FGF4

Compounds for genes affiliated with Testicular Cancer

about this section
Sources:
32Novoseek , 34PharmGKB, 9DrugBank, 42Tocris Bioscience, 18HMDB
See all sources

Compounds related to testicular cancer according to GeneDecks:

(show top 50)    (show all 459)
idCompoundScoreTop Affiliating Genes
1cyclophosphamide32 34 9 9 13.9MVP
2threonine32 9.8FSHR, CDKN2C, CDKN1B, CDC42, INSL3, GPRC6A
3rapamycin32 42 10.5MYB, LGALS1, FLT4, AR, MDM2, CCNA2
4mitomycin c32 9.2MVP, ATM, MGMT, FGF2, MDM2, FAS
5epinephrine32 9 18 9 12.2BMP6, MVP, CGA, CGB5, MMP2, MMP9
6bcnu32 9.1MGMT, GSTP1, GSTT1, ERCC2, ERCC1, TP53
7ifosfamide32 9 9 11.0NAGLU, B2M, CGA, CGB, CGB5, MGMT
8atorvastatin32 34 9 18 9 13.0BMP6, RAC1, MMP2, MMP9, IL2RA, ALPP
9agar32 8.9RAC1, LGALS1, CDKN1B, CDC42, CDH1, FGF2
10adpribose32 8.7CDKN1A, MDM2, FAS, CCNA2, CCND3, IFI27
11arsenite32 18 9.6RAC1, CDKN1A, MMP9, MDM2, FAS, CCNA2
12daunorubicin32 9 9 10.6RELA, MVP, IL3, MDM2, FAS, CASP7
13benzo(a)pyrene32 8.6NAT2, XPC, CDKN1A, GSTM1, GSTP1, GSTT1
14imatinib32 34 9 9 11.6MYB, BMP6, CDKN1A, CDKN1B, IL3, MDM2
15simvastatin32 34 42 9 18 9 13.6SERPINE1, BMP6, RAC1, MMP9, ALPP, CASP7
16ly29400232 8.6XPC, CDKN1B, CDC42, CDH1, MMP2, MMP9
17camptothecin32 42 9 9 11.5MVP, ATM, CDKN1A, CDKN1B, MGMT, GSTP1
18nitric oxide32 9 18 9 11.4NAGLU, NAT2, VEGFC, BMP6, CGB5, CDKN1B
19topotecan32 9 9 10.3ATM, MGMT, GSTP1, CCNA2, IGF1, CASP7
20oxaliplatin32 34 9 9 11.3CDKN1A, MGMT, GSTM1, GSTP1, GSTT1, FAS
21bleomycin32 9 9 10.3MVP, CGB, ATM, GSTM1, GSTP1, FGF2
22progesterone32 42 9 18 9 12.2VEGFC, MYB, MVP, CGA, CGB, CGB5
23guanine32 9 18 9 11.2MYB, RAC1, FSHR, CDC42, MMP9, AR
24mg 13232 42 9.0CDKN1A, CDKN1B, CDH1, AR, MDM2, FAS
25n acetylcysteine32 7.9NAGLU, ATM, CDKN1A, CDKN1B, CDH1, MMP2
265-aza-2deoxycytidine32 7.9BMP6, SCGB3A1, BAGE, CDKN1A, CDH1, AR
27oligonucleotide32 7.9NAT2, VEGFC, MYB, BMP6, RAC1, XPC
28celecoxib32 42 34 9 18 9 12.8CDKN1A, CDKN1B, CDH1, MMP2, MMP9, MKI67
29dihydrotestosterone32 9 18 9 10.8SERPINE1, BMP6, CGA, CGB5, AR, FGF2
30depsipeptide32 7.8CDKN1A, CDH1, MMP2, IL3, FAS, CCNA2
31ribonucleic acid32 7.7VEGFC, BMP6, CGA, CGB5, FSHR, MMP2
32alanine32 7.6NAGLU, MYB, BMP6, B2M, CGA, CGB
33adenylate32 7.5SERPINE1, MYB, CGA, CGB5, FSHR, CDC42
34gemcitabine32 34 9 9 10.4CDKN1A, CDKN1B, MMP2, CCNA2, CASP3, CASP8
35adriamycin32 6.9MVP, B2M, CDKN1A, CDH1, GSTP1, IL3
36cysteine32 6.9NAGLU, NAT2, MYB, RAC1, LGALS1, CGB
37paraffin32 6.8RELA, VEGFC, LGALS1, MVP, B2M, CGA
38phosphatidylinositol32 6.8VEGFC, BMP6, RAC1, ATM, FSHR, CDKN1B
39lactate32 6.6NAGLU, BMP6, LDHB, B2M, CGA, CGB
40tgf beta132 6.5SERPINE1, BMP6, CDKN1A, CDKN1B, CDH1, MMP2
41tamoxifen32 34 9 9 9.2BMP6, CGA, CGB5, CDKN1A, CDKN1B, CDH1
42testosterone32 9 18 9 9.0RELA, VEGFC, B2M, CGA, CGB, CGB5
43sb 20358032 42 6.8BMP6, RAC1, CDKN1A, CDKN1B, CDC42, CDH1
44vegf32 5.0SERPINE1, VEGFC, RAC1, MVP, CGA, CGB
45actinomycin d32 4.7SERPINE2, SERPINE1, MYB, CGA, CGB5, CDKN1A
46pd 98,05932 4.6SERPINE1, VEGFC, BMP6, RAC1, CDKN1A, CDKN1B
47thymidine32 18 5.3NAGLU, VEGFC, MYB, BMP6, RAC1, B2M
48cycloheximide32 3.4SERPINE2, SERPINE1, MYB, BMP6, RAC1, B2M
49tyrosine32 3.3VEGFC, MYB, BMP6, RAC1, LGALS1, MVP
50serine32 2.5RELA, SERPINE2, SERPINE1, MYB, BMP6, RAC1

GO Terms for genes affiliated with Testicular Cancer

about this section
Sources:
12Gene Ontology
See all sources

Cellular components related to testicular cancer according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.5PDGFB, PDGFA, IGF1, VEGFC, SERPINE1, EGF
2nucleoplasmGO:0056547.5ERCC2, ERCC1, TP53, PPARG, PPARA, WT1
3cytoplasmGO:0057376.5TP53, PTTG1, CYP3A4, SPA17, CTCFL, TRO
4extracellular regionGO:0055766.1PDGFB, PDGFA, GHRH, GH1, GNRH1, IGF1
5cytosolGO:0058296.0HPRT1, CASP9, CASP8, CASP2, CASP3, CASP7
6extracellular spaceGO:0056155.8AFP, GNRH1, GH1, GHRH, PTN, PDGFA
7nucleusGO:0056345.6TRO, TP53, PTTG1, CTCFL, PPP1R13L, ERCC1

Biological processes related to testicular cancer according to GeneDecks:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell divisionGO:05178110.4PDGFB, PDGFA, PTN, FGF4, FGF2, VEGFC
2spermatogenesisGO:00728310.3ERCC1, PTTG1, SPA17, H2AFX, SYCP1, HPRT1
3male gonad developmentGO:00858410.3WT1, RXFP2, CTNNA1, ERCC1, AR, FSHR
4regulation of cytokine biosynthetic processGO:04203510.2IGF2BP2, IGF2BP3, IGF2BP1
5positive regulation of neuron apoptotic processGO:04352510.1CASP9, CASP2, CASP3, CASP7, ATM
6fibroblast growth factor receptor signaling pathwayGO:0085439.9KRAS, NRAS, CASP9, MDM2, FGF4, FGF2
7response to estradiol stimulusGO:0323559.9PDGFB, GH1, CASP8, CCND2, ENO2, MMP9
8positive regulation of DNA replicationGO:0457409.9CSF2, PDGFB, PDGFA, IGF1, IL3, CDC42
9actin cytoskeleton organizationGO:0300369.9PRKG1, KRAS, RHOA, PDGFB, PDGFA, NRAS
10cellular response to lithium ionGO:0712859.9PPARG, FAS, CDH1, CDKN1B
11collagen catabolic processGO:0305749.8KLK6, MMP9, MMP2, MMP16
12positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.8GHRH, GH1, IGF1, IGFBP3, AR
13positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8CSF2, GH1, IGF1, IL3
14induction of apoptosisGO:0069179.7RUNX3, STK17A, WT1, PPARG, ERCC2, CASP3
15response to hyperoxiaGO:0550939.7ALOX5, MMP9, CDKN1A, SERPINE1
16positive regulation of MAP kinase activityGO:0434069.7EGF, KRAS, PDGFB, PDGFA, GH1
17nerve growth factor receptor signaling pathwayGO:0480119.7HDAC1, KRAS, RHOA, NRAS, CASP9, CASP2
18multicellular organism growthGO:0352649.6PPP1R13L, TP53, ERCC1, ERCC2, IGF1, CDC42
19heart developmentGO:0075079.6CXADR, WT1, PDGFB, PPARA, PPARG, CASP8
20DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.4TP53, CASP2, MDM2, CDKN1B, CDKN1A, ATM
21positive regulation of apoptotic processGO:0430659.4STK17A, TP53, CASP2, ALOX12, IGFBP3, FAS
22positive regulation of MAPK cascadeGO:0434109.4PDGFB, PDGFA, IGF1, IGFBP3, IL6, AR
23proteolysisGO:0065089.4PRSS21, KLK6, KLK5, KLK13, KLK10, CASP9
24induction of apoptosis by intracellular signalsGO:0086299.3TP53, CASP9, CASP8, CASP3, CASP7, CDKN1A
25negative regulation of cell growthGO:0303089.3STK11, WT1, PPARG, TP53, TRO, FGF2
26positive regulation of cerebellar granule cell precursor proliferationGO:0219409.2EGF, IGF1, FGF2
27Ras protein signal transductionGO:0072659.1KRAS, NRAS, TP53, IGF1, CCNA2, FGF2
28response to drugGO:0424939.0ENO2, LOX, PPARG, PDGFB, ABCC1, TOP1
29positive regulation of osteoblast differentiationGO:0456698.9BMP6, MSX2, FGF2, IL6, IGF1
30positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.8PDGFB, TP53, GH1, IGF1, IL6, IL3
31negative regulation of transcription from RNA polymerase II promoterGO:0001228.8PPARA, WT1, DNMT1, RUNX3, HDAC1, PPARG
32apoptotic processGO:0069158.5CASP9, ERCC2, TP53, PPP1R13L, PNMA2, KRT18
33platelet degranulationGO:0025768.5EGF, PDGFB, PDGFA, IGF1, VEGFC, SERPINE1
34negative regulation of cell proliferationGO:0082858.1GNRH1, TP53, PTTG1, RXFP2, WT1, STK11
35platelet activationGO:0301688.1EGF, RHOA, PDGFB, PDGFA, IGF1, IL6
36negative regulation of apoptotic processGO:0430667.7RELA, ERCC2, ERCC1, TP53, CTNNA1, RXFP2
37positive regulation of transcription from RNA polymerase II promoterGO:0459447.6HDAC1, PPARA, PPARG, TP53, ERCC2, IGF1
38positive regulation of cell proliferationGO:0082847.4GHRH, PTN, NRAS, PDGFA, PDGFB, KRAS
39blood coagulationGO:0075967.3PDGFB, RHOA, KRAS, EGF, PRKG1, CXADR
40positive regulation of transcription, DNA-dependentGO:0458937.0TP53, CTCFL, PPARG, PPARA, PDGFB, WT1

Molecular functions related to testicular cancer according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1translation regulator activityGO:04518210.3IGF2BP2, IGF2BP3, IGF2BP1
2mRNA 5-UTR bindingGO:04802710.0IGF2BP2, IGF2BP3, IGF2BP1
3cyclin-dependent protein kinase inhibitor activityGO:0048619.6CASP3, CDKN1B, CDKN2C, CDKN1A
4enzyme bindingGO:0198998.6HDAC1, CSF3, H2AFX, PPARG, CYP3A4, CYP1A2
5growth factor activityGO:0080837.3PTN, PDGFA, PDGFB, EGF, CSF2, CSF3
6protein bindingGO:0055151.9CASP3, PTTG1, CTCFL, CTNNA1, PPP1R13L, PPARG

Sources for Testicular Cancer

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
Browse MalaCards: 1-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z