MCID: TST014
MIFTS: 53

Testicular Cancer malady

Rare diseases, Cancer diseases, Reproductive diseases categories

Aliases & Classifications for Testicular Cancer

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Testicular Cancer, Aliases & Descriptions:

Name: Testicular Cancer 9 41 11 43 32 3
Testicular Malignant Germ Cell Tumor 60
Malignant Neoplasm of Testis 60
Carcinoma of the Testis 60
Cancer of the Testes 41
Testicular Neoplasms 60
 
Testicular Carcinoma 43
Neoplasm of Testis 9
Testicular Tumor 9
Testis Neoplasm 9
Testis Cancer 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


External Ids:

Disease Ontology9 DOID:2998
MeSH33 D013736
NCIt38 C3404
ICD1025 C62

Summaries for Testicular Cancer

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MedlinePlus:32 Testicles, or testes, make male hormones and sperm. they are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. you can get cancer in one or both testicles. testicular cancer mainly affects young men between the ages of 20 and 39. it is also more common in men who have had abnormal testicle development have had an undescended testicle have a family history of the cancer symptoms include pain, swelling, or lumps in your testicles or groin area. doctors use a physical exam, lab tests, imaging tests, and a biopsy to diagnose testicular cancer. most cases can be treated, especially if found early. treatment options include surgery, radiation, and/or chemotherapy. regular exams after treatment are important. treatments may also cause infertility. if you may want children later on, you should consider sperm banking before treatment. nih: national cancer institute

MalaCards based summary: Testicular Cancer, also known as testicular malignant germ cell tumor, is related to germ cell cancer and endodermal sinus tumor. An important gene associated with Testicular Cancer is AFP (alpha-fetoprotein), and among its related pathways is Peptide hormone metabolism. The drugs chlorambucil and cisplatin and the compounds 11-ketotestosterone and organon have been mentioned in the context of this disorder. Affiliated tissues include the testicles, testis and testes.

Disease Ontology:9 A male reproductive system cancer that is located in the testicles.

Wikipedia:63 Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system. more...

Related Diseases for Testicular Cancer

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Diseases related to Testicular Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1germ cell cancer31.2CGA, AFP
2endodermal sinus tumor30.7AFP
3cryptorchidism30.6CGB5, AZF1, CGA, INSL3
4testicular teratoma30.5AFP, CGA
5gynecomastia30.5CGA, CGB5
6hypospadias30.5INSL3, CGA
7teratoma30.5CGB, AFP, CGA, CGB5
8extragonadal germ cell tumor30.4AFP, CGB5
9infertility30.4INSL3, CGA, CGB, AZF1
10hypogonadism30.4CGA, CGB5
11testicular disease30.4CGA, INSL3
12male infertility30.3CGA, AZF1
13choriocarcinoma30.3CGB5, CGB, AFP, CGA
14klinefelter's syndrome30.2CGA, AZF1, CGB
15oligospermia30.2CGB5, CGA, AZF1
16embryonal cancer30.1AFP, CGB, CGA, CGB5
17prostate cancer30.1XAGE1D, CGB
18seminoma30.1AFP, CGB5, CGA, CGB, SSX2
19germinoma29.9CGB5, AFP, CGA, CGB
20azoospermia29.8INSL3, CGA, CGB5, AZF1
21sarcoma29.6CGB5, SSX2, CGB
22adenocarcinoma29.6XAGE1D, AFP, CGB, CGB5
23testicular microlithiasis10.5
24oligohydramnios10.5AFP
25anencephaly10.4AFP, CGA
26encephalitis10.4
27prostatitis10.4
28ovarian mixed germ cell neoplasm10.4CGA, AFP
29edwards syndrome10.3CGA, AFP
30rete testis neoplasm10.3
31varicocele10.3AZF1, CGA
32leydig cell tumor10.3CGA, CGB5
33dermatomyositis10.3
34limbic encephalitis10.3
35congenital adrenal hyperplasia10.3
36turner syndrome10.3CGA, CGB
37trophoblastic neoplasm10.2CGB5, CGA
38ovarian cyst10.2CGA, CGB5
39ovarian hyperstimulation syndrome10.2CGB5, CGA
40breast cancer10.2
41kidney disease10.2
42mature teratoma10.2
43testicular cancer, childhood10.2
44resistance to bleomycine in the treatment of testicular cancer10.2
45precocious puberty10.2CGB5, CGA
46kallmann syndrome10.2CGB5, CGA
47polycystic ovary syndrome10.2CGA, CGB5
48cryptococcosis10.2CGB5, CGB
49pregnancy loss, recurrent 110.2CGB5, CGA
50hypercalcemia10.2

Graphical network of the top 20 diseases related to Testicular Cancer:



Diseases related to testicular cancer

Symptoms for Testicular Cancer

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Drugs & Therapeutics for Testicular Cancer

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Drug clinical trials:

Search ClinicalTrials for Testicular Cancer

Search NIH Clinical Center for Testicular Cancer

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Testicular Cancer

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Anatomical Context for Testicular Cancer

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MalaCards organs/tissues related to Testicular Cancer:

31
Testis, Testes, Lymph node, Skin, Prostate, Lung, Breast, Kidney, Bone, Brain, Pituitary, Heart, Colon, Liver, Spleen, Myeloid, Endothelial, Pineal

FMA organs/tissues related to Testicular Cancer:

14
The testicles

Animal Models for Testicular Cancer or affiliated genes

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Publications for Testicular Cancer

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Articles related to Testicular Cancer:

(show top 50)    (show all 660)
idTitleAuthorsYear
1
Hypogonadism and fertility issues following primary treatment for testicular cancer. (25736189)
2015
2
Serum metallothionein in patients with testicular cancer. (25700685)
2015
3
Reply: Comment on 'Chemotherapy for testicular cancer induces acute alterations in diastolic heart function'. (24201753)
2014
4
Genetic and epigenetic analysis of monozygotic twins discordant for testicular cancer. (25379132)
2014
5
Androgen receptor polymorphisms and testicular cancer risk. (25180665)
2014
6
International testicular cancer incidence trends: generational transitions in 38 countries 1900-1990. (25388800)
2014
7
Selective induction of glutathione S-transferases in round spermatids from the Brown-Norway rat by the chemotherapeutic regimen for testicular cancer. (23200778)
2013
8
Surgery for treatment of metastatic testicular cancer. (24171695)
2013
9
Bilateral germ-cell testicular cancer - long-term experience. (24320591)
2013
10
Effect of endogenous and exogenous hormones on testicular cancer: the epidemiological evidence. (23784836)
2013
11
Current management of testicular cancer. (23362440)
2013
12
Age at puberty and risk of testicular cancer: a meta-analysis. (22713104)
2012
13
Probability of metachronous testicular cancer in patients with biopsy-proven intratubular germ cell neoplasia depends on first-time treatment of germ cell cancer. (23071246)
2012
14
Impact of long-term serum platinum concentrations on neuro- and ototoxicity in Cisplatin-treated survivors of testicular cancer. (22184390)
2012
15
Testicular cancer. (22846486)
2012
16
Testicular cancer and the tuberous sclerosis complex. (21767201)
2012
17
Retroperitoneal lymphadenectomy and resection for testicular cancer: an update on best practice. (22852029)
2012
18
The clinical utility of testicular cancer risk loci. (21255381)
2011
19
Minimally invasive retroperitoneal lymph node dissection for testicular cancer. (22045176)
2011
20
Initial series of robot-assisted laparoscopic retroperitoneal lymph node dissection for clinical stage I nonseminomatous germ cell testicular cancer. (21420231)
2011
21
The pituitary-Leydig cell axis before and after orchiectomy in patients with stage I testicular cancer. (21704509)
2011
22
PET in testicular cancer. (21331937)
2011
23
A stratified genetic risk assessment for testicular cancer. (21564132)
2011
24
The predictive value of testicular ultrasound abnormalities for carcinoma in situ of the testis in men at risk for testicular cancer. (19845800)
2010
25
Testicular cancer. Does the dose intensity of BeP chemotherapy affect survival? (20836283)
2010
26
Vascular damage in testicular cancer patients: a study on endothelial activation by bleomycin and cisplatin in vitro. (19956889)
2010
27
Emotional disorders in testicular cancer survivors in relation to hypogonadism, androgen receptor polymorphism and treatment modality. (19656574)
2010
28
Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer. (20811155)
2010
29
Long-term neurologic and peripheral vascular toxicity after chemotherapy treatment of testicular cancer. (20225230)
2010
30
Optimal management of testicular cancer: from self-examination to treatment of advanced disease. (24198622)
2010
31
A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer--experiences of the son. (20660640)
2010
32
Prenatal DDT exposure and testicular cancer: a nested case-control study. (20705572)
2010
33
Simultaneous bilateral spontaneous pneumothorax in metastatic testicular cancer. (19140040)
2009
34
Upper gastrointestinal bleeding from metastatic testicular cancer. (19715045)
2009
35
Factors associated with testicular self-examination among unaffected men from multiple-case testicular cancer families. (19480691)
2009
36
Surgical management of low-stage nonseminomatous germ cell testicular cancer. (19840014)
2009
37
Diagnosis and treatment of testicular cancer. (18326165)
2008
38
A case of spermatic cord teratoma in low-stage testicular cancer managed by surveillance. (18268549)
2008
39
Subfertility among parents of men diagnosed with testicular cancer. (17822418)
2008
40
Gynaecomastia: an endocrine manifestation of testicular cancer. (18477201)
2008
41
Laparoscopic retroperitoneal lymph node dissection for low-stage testicular cancer. (18613781)
2008
42
A case of metastatic testicular cancer complicated by tumour lysis syndrome and choriocarcinoma syndrome. (16935862)
2006
43
A case of Sweet's syndrome following septic pulmonary emboli after high-dose chemotherapy for advanced testicular cancer. (16734883)
2006
44
XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer. (14723995)
2004
45
Asessment of paraneoplastic limbic encephalitis in testicular cancer. (12846502)
2003
46
MRP expression of testicular cancers and its clinical relevance. (11268495)
2000
47
Expression of proteins correlated with the unique cisplatin-sensitivity of testicular cancer. (9066679)
1997
48
High-dose treatment with carboplatin, etoposide, and ifosfamide followed by autologous stem-cell transplantation in relapsed or refractory germ cell cancer: a phase I/II study. The German Testicular Cancer Cooperative Study Group. (7911158)
1994
49
Early clinical stages (CS1, CS1Mk+ and CS2A) of non-seminomatous testis cancer. Value of pre- and post-orchiectomy serum tumor marker information in prediction of retroperitoneal lymph node metastases. Swedish-Norwegian Testicular Cancer Project (SWENOTECA). (1702312)
1990
50
A case of complete remission obtained with etoposide cis-platinum combination chemotherapy in advanced testicular cancer]. (1689134)
1990

Variations for Testicular Cancer

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Expression for genes affiliated with Testicular Cancer

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Search GEO for disease gene expression data for Testicular Cancer.

Pathways for genes affiliated with Testicular Cancer

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Pathways related to Testicular Cancer according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3CGB5, CGA, CGB

Compounds for genes affiliated with Testicular Cancer

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Compounds related to Testicular Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
111-ketotestosterone4310.0CGB5, CGA
2organon4310.0CGB5, CGA
3thyroxine43 2411.0AFP, CGB, CGA
4trilostane43 1211.0CGB5, CGA
5estradiol benzoate4310.0CGB5, CGA
617-hydroxypregnenolone4310.0CGA, CGB5
7leuprolide43 59 28 1213.0CGA, CGB5
8dihydroprogesterone4310.0CGA, CGB5
9cetrorelix43 28 1211.9CGA, CGB5
108-bromo-cyclic amp439.9CGA, CGB5
1122r-hydroxycholesterol43 2810.9CGA, CGB5
12buserelin43 28 1211.9CGB5, CGA
13leuprolide acetate439.9CGB5, CGA
14lutein439.9CGB5, CGA
15(+-)-pgf2-alpha439.8CGA, CGB5
1625-hydroxycholesterol43 28 2411.8CGA, CGB5
17percoll439.8CGA, CGB5
18vinblastine43 49 1211.7AFP, CGA, CGB5
1917-hydroxyprogesterone43 2410.7CGA, CGB5
20ctp439.7CGB5, CGA, CGB
21androstenedione43 2410.7CGB5, CGA, CGB
22vincristine43 49 1211.7AFP, CGB, CGB5
233beta-hydroxysteroid439.7INSL3, CGA, CGB5
24folate439.6CGB5, CGA, AFP
25dmso439.6CGB5, CGA, AFP
26naloxone43 28 49 1212.6CGB5, CGA
27gnrh439.5CGB5, CGA, CGB
28oestriol439.5CGB5, CGA, CGB, AFP
29clomiphene citrate439.5AFP, CGB, CGA, CGB5
30ifosfamide43 1210.5AFP, CGB, CGA, CGB5
31bleomycin43 1210.5AFP, CGB, CGA, CGB5
32mifepristone43 28 59 1212.5AFP, CGB, CGA, CGB5
33cyclophosphamide43 49 1211.5AFP, CGB, CGA, CGB5
34methotrexate49 43 1211.5CGB5, CGA, CGB, AFP
35diethylstilbestrol43 28 1211.5CGB5, CGA, AFP, INSL3
36etoposide43 49 59 1212.5CGB5, CGA, CGB, AFP
37epinephrine43 24 1211.4CGB5, CGA, AFP
38estradiol43 24 1211.4AFP, CGB, CGA, CGB5
39lactate439.4AFP, CGB, CGA, CGB5
40cisplatin43 49 59 1212.4CGB5, CGA, CGB, AFP
41creatinine439.4CGB5, CGA, CGB, AFP
42alanine439.3INSL3, AFP, CGB, CGA
43progesterone43 28 59 24 1213.3AFP, CGB, CGA, CGB5
44nitrate439.3CGB5, AFP
45cyclic amp43 2410.3INSL3, CGB, CGA, CGB5
46steroid439.2CGB5, CGA, AFP, INSL3
47testosterone43 59 24 1212.1INSL3, AFP, CGB, CGA, CGB5
48ethanol43 49 24 1212.1CGB5, ACPT, AFP
49estrogen439.1CGB5, CGA, CGB, AFP, INSL3
50vegf439.1AFP, CGB, CGA, CGB5

GO Terms for genes affiliated with Testicular Cancer

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Biological processes related to Testicular Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:00164869.6CGA, CGB
2cell-cell signalingGO:00072679.6CGA, CGB, INSL3

Molecular functions related to Testicular Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.6CGA, CGB, INSL3

Products for genes affiliated with Testicular Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Testicular Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet