MCID: TST014
MIFTS: 58

Testicular Cancer malady

Cancer diseases, Reproductive diseases categories

Summaries for Testicular Cancer

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Sources:
33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Testicles, or testes, make male hormones and sperm. they are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. you can get cancer in one or both testicles. testicular cancer mainly affects young men between the ages of 20 and 39. it is also more common in men who have had abnormal testicle development have had an undescended testicle have a family history of the cancer symptoms include pain, swelling, or lumps in your testicles or groin area. doctors use a physical exam, lab tests, imaging tests, and a biopsy to diagnose testicular cancer. most cases can be treated, especially if found early. treatment options include surgery, radiation, and/or chemotherapy. regular exams after treatment are important. treatments may also cause infertility. if you may want children later on, you should consider sperm banking before treatment. nih: national cancer institute

MalaCards: Testicular Cancer, also known as malignant neoplasm of testis, is related to cryptorchidism and seminoma. An important gene associated with Testicular Cancer is AFP (alpha-fetoprotein), and among its related pathways is Glycoprotein hormones. The drugs cyclophosphamide and cisplatin and the compounds oestriol and clomiphene citrate have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and lymph node.

Wikipedia:63 Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system. more...

Description from OMIM:46 273300

Aliases & Classifications for Testicular Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

testicular cancer 8 42 10 44 33
malignant neoplasm of testis 60
carcinoma of the testis 60
cancer of the testes 42
testicular carcinoma 44
testicular neoplasms 60
neoplasm of testis 8
testicular tumor 8
testis neoplasm 8
testis cancer 8


External Ids:

Disease Ontology8 DOID:2998
NCIt39 C3404
MeSH34 D013736
OMIM46 273300
ICD1025 C62

Related Diseases for Testicular Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Testicular Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1cryptorchidism30.6AZF1, CGA, CGB5
2seminoma30.5CGA, CGB5, CGB, AFP, SSX2, MAGEA1
3prostate cancer30.5CTAG1B, CGB, XAGE1D
4lung cancer30.4CCNA1, CTAG1B, CGB, MAGEA3, MAGEA1, MAGEA4
5infertility30.4AZF1, CGA, CGB, TRO
6male germ cell tumor, somatic30.4CGA, AFP
7breast cancer30.3CCNA1, CTAG1B, CGB, SSX2, MAGEA3, MAGEA1
8embryonal cancer30.2CGA, CGB5, CGB, AFP
9gynecomastia30.1CGA, CGB5
10leukemia30.1CCNA1, CTAG1B, CGB, MAGEA3, MAGEA1
11choriocarcinoma30.1CGA, CGB5, CGB, AFP
12ovarian cancer29.9CTAG1B, CGB5, CGB, PRSS21, AFP, SSX2
13sarcoma29.9CTAG1B, CGB5, CGB, SSX2, MAGEA3, MAGEA1
14oligospermia29.9CGB5, CGA, AZF1
15leydig cell tumor29.9CGB5, CGA
16azoospermia29.9AZF1, CGA, CGB5
17colorectal cancer29.9MAGEA1, MAGEA3, CGB
18klinefelter's syndrome29.9AZF1, CGA, CGB
19endodermal sinus tumor29.9AFP
20retroperitoneal cancer10.7
21lymph node cancer10.7
22testicular disease10.5
23vascular cancer10.4
24embryonal testis carcinoma10.3
25encephalitis10.3
26prostatitis10.3
27sarcoidosis10.3
28dermatomyositis10.2
29kidney cancer10.2
30congenital adrenal hyperplasia10.2
31rete testis neoplasm10.2
32testicular lymphoma10.2
33brain cancer10.2
34heart cancer10.2
35hypogonadism10.2
36kidney disease10.2
37mature teratoma10.2
38pituitary cancer10.2
39polyarteritis nodosa10.1
40hypercalcemia10.1
41astrocytoma10.1
42malignant leydig cell tumor10.1
43mixed germ cell cancer10.1
44acute leukemia10.1
45hyperthyroidism10.1
46adenomatoid tumor10.1
47adrenal carcinoma10.1
48male breast cancer10.1
49testicular leukemia10.1
50testicular infarct10.1

Graphical network of the top 20 diseases related to Testicular Cancer:



Diseases related to testicular cancer

Clinical Features for Testicular Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

273300

Drugs & Therapeutics for Testicular Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Testicular Cancer

Drug clinical trials:

Search ClinicalTrials for Testicular Cancer

Search NIH Clinical Center for Testicular Cancer

Search CenterWatch for Testicular Cancer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Testicular Cancer

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Anatomical Context for Testicular Cancer

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Sources:
32MalaCards
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MalaCards organs/tissues related to Testicular Cancer:

32
Testis, Testes, Lymph node, Skin, Prostate, Breast, Lung, Kidney, Pituitary, Heart, Brain, Liver, Bone, Colon, Spleen, B cells, Endothelial, Pineal, Myeloid

Animal Models for Testicular Cancer or affiliated genes

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Publications for Testicular Cancer

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Sources:
50PubMed
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Articles related to Testicular Cancer:

(show top 50)    (show all 771)
idTitleAuthorsYear
1
Longitudinal Serum Testosterone, Luteinizing Hormone, and Follicle-Stimulating Hormone Levels in a Population-Based Sample of Long-Term Testicular Cancer Survivors. (24419125)
2014
2
Effect of endogenous and exogenous hormones on testicular cancer: the epidemiological evidence. (23784836)
2013
3
International Variations and Trends in Testicular Cancer Incidence and Mortality. (24268506)
2013
4
microRNA-199a-3p, DNMT3A, and aberrant DNA methylation in testicular cancer. (23959088)
2013
5
Prostatic metastases from testicular nonseminomatous germ cell cancer: two case reports and a review of the literature. (24362870)
2013
6
Occupational risk factors for testicular cancer: a registry-based case-control study in Rhineland Palatinate-Germany. (24265602)
2013
7
Health-related quality of life, depression, and sexual function in testicular cancer survivors in a developing country: a Serbian experience. (22933132)
2013
8
Psychological needs when diagnosed with testicular cancer: findings from a population-based study with long-term follow-up. (23469865)
2013
9
Probability of metachronous testicular cancer in patients with biopsy-proven intratubular germ cell neoplasia depends on first-time treatment of germ cell cancer. (23071246)
2012
10
Hyperglycosylated human chorionic gonadotropin in serum of testicular cancer patients. (22529110)
2012
11
Anti-tumour activity of two novel compounds in cisplatin-resistant testicular germ cell cancer. (23169338)
2012
12
Thirty year trends in testicular cancer mortality in Europe: gaps persist between the East and West. (22548368)
2012
13
Initial series of robot-assisted laparoscopic retroperitoneal lymph node dissection for clinical stage I nonseminomatous germ cell testicular cancer. (21420231)
2011
14
I+vI^3 imaging can accurately distinguish between mature teratoma and necrosis in 18F-FDG-negative residual masses after treatment of non-seminomatous testicular cancer: a preclinical study. (20882281)
2011
15
Population-based study of treatment guided by tumor marker decline in patients with metastatic nonseminomatous germ cell tumor: a report from the Swedish-Norwegian Testicular Cancer Group. (21482994)
2011
16
Risk-adapted treatment in clinical stage I testicular seminoma: the third Spanish Germ Cell Cancer Group study. (22042940)
2011
17
Proceedings of the 7th Copenhagen Workshop on Testicular Carcinoma in situ and Germ Cell Cancer, 13-15 October 2010. (21790649)
2011
18
Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma. (22016418)
2011
19
Association of PAI-1 gene polymorphism with survival and chemotherapy-related vascular toxicity in testicular cancer. (20737565)
2010
20
Late complications of chemotherapy in testicular cancer. (20092952)
2010
21
Testicular cancer: Decision tree model has potential to improve NSGCT management. (20535145)
2010
22
Preservation of ejaculation in patients undergoing nerve-sparing postchemotherapy retroperitoneal lymph node dissection for metastatic testicular cancer. (19022490)
2009
23
Long-term cognitive function following chemotherapy in patients with testicular cancer. (19203434)
2009
24
Damage of hormonal function and bone metabolism in long-term survivors of testicular cancer. (19728753)
2009
25
Subtype-specific incidence of testicular cancer in Germany: a pooled analysis of nine population-based cancer registries. (18179558)
2009
26
Is increased body mass index associated with the incidence of testicular germ cell cancer? (19002497)
2009
27
Editorial comment on: Postchemotherapy retroperitoneal lymph node dissection in advanced testicular cancer: radical or modified template resection. (18926621)
2009
28
Perinatal markers of estrogen exposure and risk of testicular cancer: follow-up of 1,333,873 Danish males born between 1950 and 2002. (19636804)
2009
29
A case of spermatic cord teratoma in low-stage testicular cancer managed by surveillance. (18268549)
2008
30
Testicular cancer risk in first- and second-generation immigrants to Denmark. (18159067)
2008
31
Testicular sperm extraction in a single cancerous testicle in patients with azoospermia: a case report. (18023440)
2008
32
Doubling of testicular cancer incidence rate over the last 20 years in southern France. (18236173)
2008
33
Late relapse of testicular cancer 21 years after first complete remission: a case report. (18260359)
2008
34
Testicular cancer and hormonally active agents. (18368556)
2008
35
Epidemiology and treatment delay in testicular cancer patients: a retrospective study. (17634758)
2008
36
Stage I testicular cancer management and necessity for surgical expertise. (18458042)
2008
37
Evidence-based pragmatic guidelines for the follow-up of testicular cancer: optimising the detection of relapse. (18542063)
2008
38
Recent advances and future directions in research on testicular germ cell cancer. (17705803)
2007
39
Cisplatin-induced long-term hearing impairment is associated with specific glutathione s-transferase genotypes in testicular cancer survivors. (17228018)
2007
40
Intracytoplasmic sperm injection by testicular sperm in patients with aspermia or azoospermia after cancer treatment. (16524365)
2006
41
Single agent carboplatin for CS IIA/B testicular seminoma. A phase II study of the German Testicular Cancer Study Group (GTCSG). (16254023)
2006
42
Molecular analysis of the androgen receptor gene in testicular cancer. (16172197)
2005
43
Clinical parameters that predict histology of postchemotherapy retroperitoneal lymph node mass in testicular cancer. (15242364)
2004
44
Gynecomastia following chemotherapy for testicular cancer. (12660472)
2003
45
Expression patterns of cancer testis antigens in testicular germ cell tumors and adjacent testicular tissue. (11342977)
2001
46
Paraneoplastic limbic encephalitis, a complication of the testicular cancer. (11445490)
2001
47
Correlation between expression of metastasis-related genes and lymph node metastasis in testicular cancer]. (11215209)
2000
48
Expression of proteins correlated with the unique cisplatin-sensitivity of testicular cancer. (9066679)
1997
49
Testicular versus breast and colorectal cancer screening: early detection practices of primary care physicians. (7663550)
1995
50
Unnecessary mastectomy for gynecomastia in testicular cancer patient. (1382250)
1992

Genetic Variations for Testicular Cancer

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Expression for genes affiliated with Testicular Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Testicular Cancer

Search GEO for disease gene expression data for Testicular Cancer.

Pathways for genes affiliated with Testicular Cancer

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53Reactome
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Pathways related to Testicular Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6CGB, CGA

Compounds for genes affiliated with Testicular Cancer

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Testicular Cancer according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1oestriol4411.0AFP, CGB, CGB5, CGA
2clomiphene citrate4411.0CGA, CGB5, CGB, AFP
3ifosfamide44 1112.0AFP, CGB, CGB5, CGA
4bleomycin44 1112.0CGA, CGB5, CGB, AFP
5paraffin4411.0CGA, CGB5, AFP, MAGEA3, MAGEA1
6mifepristone44 59 28 1114.0CGA, CGB5, CGB, AFP
7cyclophosphamide44 49 1113.0AFP, CGB, CGB5, CGA
8ctp4411.0CGB, CGB5, CGA
9methotrexate44 49 1113.0CGA, CGB5, CGB, AFP
105-aza-2deoxycytidine4410.9CTAG1B, SSX2, BAGE, MAGEA1
11etoposide44 49 59 1113.9CGA, CGB5, CGB, AFP
12diethylstilbestrol44 28 1112.9AFP, CGB5, CGA
1311-ketotestosterone4410.9CGA, CGB5
14vinblastine44 49 1112.9AFP, CGB5, CGA
15organon4410.9CGA, CGB5
16androstenedione44 2411.9CGB, CGB5, CGA
17trilostane44 1111.8CGB5, CGA
18estradiol benzoate4410.8CGA, CGB5
1917-hydroxypregnenolone4410.8CGA, CGB5
20leuprolide44 59 28 1113.8CGA, CGB5
21dihydroprogesterone4410.8CGB5, CGA
22cetrorelix44 28 1112.8CGA, CGB5
23vincristine44 49 1112.7AFP, CGB, CGB5
248-bromo-cyclic amp4410.7CGA, CGB5
2522r-hydroxycholesterol44 2811.7CGA, CGB5
26vegf4410.7AFP, CGB, CGB5, CGA, CCNA1
27leuprolide acetate4410.6CGB5, CGA
28buserelin44 28 1112.6CGB5, CGA
29estradiol44 11 2412.5CGA, CGB5, CGB, AFP
30lutein4410.2CGB5, CGA

GO Terms for genes affiliated with Testicular Cancer

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16Gene Ontology
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Biological processes related to Testicular Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:01648610.6CGB, CGA

Products for genes affiliated with Testicular Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Testicular Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet