MCID: TST026
MIFTS: 44

Testicular Germ Cell Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Testicular Germ Cell Cancer

MalaCards integrated aliases for Testicular Germ Cell Cancer:

Name: Testicular Germ Cell Cancer 12 14
Testicular Germ Cell Tumor 41 69
Testicular Malignant Germ Cell Tumor 69
Testicular Germ Cell Neoplasm 12
Germ Cell Tumor of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5557
MeSH 41 C563236
NCIt 46 C8591
SNOMED-CT 64 713577007
UMLS 69 C1336708

Summaries for Testicular Germ Cell Cancer

Disease Ontology : 12 A testicular cancer that has material basis in germ cells.

MalaCards based summary : Testicular Germ Cell Cancer, also known as testicular germ cell tumor, is related to testicular germ cell tumor and estrogen excess. An important gene associated with Testicular Germ Cell Cancer is DMRT1 (Doublesex And Mab-3 Related Transcription Factor 1), and among its related pathways/superpathways are Coregulation of Androgen receptor activity and Ovarian Infertility Genes. The drugs Cisplatin and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testis, and related phenotypes are growth/size/body region and limbs/digits/tail

Related Diseases for Testicular Germ Cell Cancer

Diseases in the Testicular Germ Cell Cancer family:

Testicular Malignant Germ Cell Cancer

Diseases related to Testicular Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 33.2 AR DMRT1 ESR2 KITLG SPRY4
2 estrogen excess 29.9 ESR2 LHCGR
3 testicular germ cell tumor 1 12.5
4 pediatric testicular germ cell tumor 12.4
5 testicular germ cell tumor non-seminomatous 12.2
6 testicular seminoma 11.5
7 pigmented villonodular synovitis 11.2
8 germ cells tumors 11.1
9 postmenopausal atrophic vaginitis 10.3 AR ESR2
10 transsexualism 10.3 AR ESR2
11 gender identity disorder 10.3 AR ESR2
12 vaginitis 10.3 AR ESR2
13 oligospermia 10.2 AR KITLG
14 prostatic hypertrophy 10.2 ALPP AR
15 penis agenesis 10.2 AR LHCGR
16 serous cystadenocarcinoma 10.1 ALPP ESR2
17 sex differentiation disease 10.1 AR LHCGR
18 aging 10.1
19 cystadenocarcinoma 10.1 ALPP ESR2
20 malignant germ cell tumor 10.1 ALPP AR ESR2
21 pseudohermaphroditism 10.0 AR LHCGR
22 stroke, ischemic 10.0
23 dermatomyositis 10.0
24 cerebritis 10.0
25 male reproductive organ cancer 9.9 AR ESR2
26 intussusception 9.8
27 cryptorchidism, unilateral or bilateral 9.8
28 body mass index quantitative trait locus 1 9.8
29 thrombocytopenia 9.8
30 ulcerative colitis 9.8
31 colitis 9.8
32 hypospadias 9.8
33 hypogonadism 9.8
34 testicular cancer 9.8
35 seminoma 9.8
36 infertility 9.8
37 male reproductive system disease 9.7 AR RBMY1A1
38 reproductive system disease 9.3 AR ESR2 LHCGR RBMY1A1

Graphical network of the top 20 diseases related to Testicular Germ Cell Cancer:



Diseases related to Testicular Germ Cell Cancer

Symptoms & Phenotypes for Testicular Germ Cell Cancer

MGI Mouse Phenotypes related to Testicular Germ Cell Cancer:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.5 AR BLMH ESR2 KITLG LHCGR PIAS1
2 limbs/digits/tail MP:0005371 9.1 AR BLMH ESR2 KITLG LHCGR SPRY4

Drugs & Therapeutics for Testicular Germ Cell Cancer

Drugs for Testicular Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 305)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
2
Testosterone Approved, Investigational Phase 4,Phase 2,Phase 3 58-22-0 6013
3
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
4
Methyltestosterone Approved Phase 4,Phase 2,Phase 3 58-18-4 6010
5
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
6 interferons Phase 4,Phase 1,Phase 2
7 Adjuvants, Immunologic Phase 4,Phase 3,Phase 1,Phase 2
8 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
9 Hormones Phase 4,Phase 2,Phase 3,Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
11 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
12 Testosterone undecanoate Phase 4,Phase 2,Phase 3
13
Testosterone enanthate Phase 4,Phase 2,Phase 3 315-37-7 9416
14 Testosterone 17 beta-cypionate Phase 4,Phase 2,Phase 3
15 Anabolic Agents Phase 4,Phase 2,Phase 3
16 Androgens Phase 4,Phase 2,Phase 3
17 Interferon Inducers Phase 4,Phase 1,Phase 2
18 Estradiol valerate Phase 4,Phase 3 979-32-8
19 Follicle Stimulating Hormone Phase 4
20 Estradiol 17 beta-cypionate Phase 4,Phase 3
21 Estradiol 3-benzoate Phase 4,Phase 3
22 Polyestradiol phosphate Phase 4,Phase 3
23
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 50-02-2 5743
24
Vinblastine Approved Phase 3 865-21-4 241903 13342
25
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
26
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
27
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
28
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
29
Bleomycin Approved, Investigational Phase 3,Phase 2 11056-06-7 5360373
30
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
31
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
32
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 43805 6857599 5310940 9887054
33
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
34
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
35
Lenograstim Approved, Investigational Phase 2, Phase 3, Phase 1 135968-09-1
36
Captopril Approved Phase 3 62571-86-2 44093
37
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
38
Ribavirin Approved Phase 3 36791-04-5 37542
39
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
40
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
41
Ofloxacin Approved Phase 3 82419-36-1 4583
42
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
43
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
44
Palivizumab Approved, Investigational Phase 3 188039-54-5
45
Caspofungin Approved Phase 3,Phase 2 162808-62-0, 179463-17-3 2826718 468682
46
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
47
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
48
Promethazine Approved, Investigational Phase 3 60-87-7 4927
49
Mycophenolic acid Approved Phase 3 24280-93-1 446541
50
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078

Interventional clinical trials:

(show top 50) (show all 284)

# Name Status NCT ID Phase Drugs
1 Taste, Smell and Chemotherapy (TASTY) Completed NCT01641172 Phase 4
2 Effect of Topical Imiquimod on Lentigo Maligna Completed NCT01161888 Phase 4 Imiquimod
3 Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters Recruiting NCT03203681 Phase 4 NATESTO® (4.5% nasal testosterone) Nasal Gel
4 Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors Unknown status NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
5 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
6 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
7 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
8 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
9 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
10 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
11 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
12 Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles Completed NCT00324298 Phase 3 cisplatin;etoposide
13 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
14 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
15 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
16 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
17 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
18 Androgen for Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3 Testosterone undecanoate;Castor Oil
19 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
20 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
21 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
22 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
23 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
24 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
25 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
26 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
27 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
28 Study of Testosterone vs Placebo in Testicular Cancer Survivors Recruiting NCT02991209 Phase 2, Phase 3 Testosterone;Placebos
29 Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
30 Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours Recruiting NCT02582697 Phase 3 Bleomycin (active name: Bleomycin Sulfate);Etoposide;Cisplatin;Pegylated G-CSF (Pegfilgrastim);Filgrastim
31 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
32 Trial of 1 Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Testis Tumours Active, not recruiting NCT01726374 Phase 3 BEP(500)
33 Hypofractionated, Dose Escalation Radiotherapy for High Risk Adenocarcinoma of the Prostate Active, not recruiting NCT01444820 Phase 3
34 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
35 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
36 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
37 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
38 Sorafenib Monotherapy in Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy Unknown status NCT00772694 Phase 2 sorafenib
39 Peptide Vaccination in Treating Patients With Esophageal Cancer (STF-II) Unknown status NCT01267578 Phase 2
40 A Study With Peptide Vaccination in Treating Patients With Esophageal Cancer Unknown status NCT00995358 Phase 2
41 Phase II Study of S-488410 to Treat Non-small Cell Lung Cancer Unknown status NCT01592617 Phase 2 S-488410
42 Safety and Efficacy Study of Epitope Peptide To Treat HLA-A*02 Disease Controlled Advanced Non-small Cell Lung Cancer Unknown status NCT01949701 Phase 1, Phase 2
43 Sutent and Radiation as Treatment for Limited Extent Metastatic Cancer Unknown status NCT00463060 Phase 1, Phase 2 sunitinib malate (Sutent)
44 Pazopanib in Advanced and Cisplatin-resistant Germ Cell Tumors Unknown status NCT01743482 Phase 2 Pazopanib
45 Promotora-based Latino Family CVD Risk Reduction Unknown status NCT01714271 Phase 2
46 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
47 Trial of Gemcitabine, Cisplatin, and Ifosfamide in Patients With Relapsed Non-Seminomatous Germ-Cell Tumors Unknown status NCT00127049 Phase 2 gemcitabine, ifosfamide, cisplatin, G-CSF
48 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
49 Everolimus in Refractory Testicular Germ Cell Cancer Completed NCT01466231 Phase 2 Everolimus
50 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel

Search NIH Clinical Center for Testicular Germ Cell Cancer

Cochrane evidence based reviews: testicular germ cell tumor

Genetic Tests for Testicular Germ Cell Cancer

Anatomical Context for Testicular Germ Cell Cancer

MalaCards organs/tissues related to Testicular Germ Cell Cancer:

38
Bone, Bone Marrow, Testis, T Cells, Lung, Lymph Node, Brain

Publications for Testicular Germ Cell Cancer

Articles related to Testicular Germ Cell Cancer:

(show top 50) (show all 116)
# Title Authors Year
1
Is the FSHR 2039A>G variant associated with susceptibility to testicular germ cell cancer? ( 29179257 )
2018
2
Animacroxam, a novel dual-mode compound targeting histone deacetylases and cytoskeletal integrity of testicular germ cell cancer cells. ( 28838999 )
2017
3
microRNA-371a-3p as informative biomarker for the follow-up of testicular germ cell cancer patients. ( 28612337 )
2017
4
Risk of low bone mineral density in testicular germ cell cancer survivors: association with hypogonadism and treatment modality. ( 28591464 )
2017
5
Cisplatin-related Cerebral Infarction in Testicular Germ Cell Cancer: Short Report of Three Cases and P in testicular germ cell cancer: Short report of three cases and pathomechanism. ( 27923208 )
2017
6
A Brief Review of the Link between Environment and Male Reproductive Health: Lessons from Studies of Testicular Germ Cell Cancer. ( 26871895 )
2016
7
Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment. ( 27873769 )
2016
8
Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review. ( 27821802 )
2016
9
Surveillance policy for Japanese patients with stage I testicular germ cell cancer in the multi-detector computed tomography era. ( 25893862 )
2015
10
Reply to Nahid Punjani, Nicholas Power, Eric Winquist's Letter to the Editor re: Yvonne Vergouwe, Ewout W. Steyerberg, Richard S. Foster, et al. Predicting Retroperitoneal Histology in Postchemotherapy Testicular Germ Cell Cancer: A Model Update and Multicentre Validation with More Than 1000 Patients. Eur Urol 2007;51:424-32. ( 26726124 )
2015
11
Increasing international efforts to understand and conquer testicular germ cell cancer. ( 25711179 )
2015
12
Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts. ( 25826226 )
2015
13
Treatment-related cardiovascular late effects and exercise training countermeasures in testicular germ cell cancer survivorship. ( 25751759 )
2015
14
Re: Yvonne Vergouwe, Ewout W. Steyerberg, Richard S. Foster, et al. Predicting Retroperitoneal Histology in Postchemotherapy Testicular Germ Cell Cancer: A Model Update and Multicentre Validation with More Than 1000 Patients. Eur Urol 2007;51:424-32. ( 26726125 )
2015
15
Salvage chemotherapy with gemcitabine plus oxaliplatin for patients with testicular germ cell cancer. ( 24647526 )
2014
16
Circulating Serum miRNA (miR-367-3p, miR-371a-3p, miR-372-3p and miR-373-3p) as Biomarkers in Patients with Testicular Germ Cell Cancer. ( 25046619 )
2014
17
Nodal, pulmonary and pleural gliomatosis in a 42-year-old-male with non-seminomatous testicular germ cell cancer. ( 24444134 )
2014
18
An oncofetal and developmental perspective on testicular germ cell cancer. ( 25066859 )
2014
19
Trends in testicular germ cell cancer incidence in Eastern Croatia. ( 24496357 )
2014
20
Changes in epidemiologic features of testicular germ cell cancer: Age at diagnosis and relative frequency of seminoma are constantly and significantly increasing. ( 23395239 )
2014
21
Re: Anti-tumour activity of two novel compounds in cisplatin-resistant testicular germ cell cancer. ( 24120784 )
2013
22
Just another brick in the wall: unravelling the epigenetic mechanism underlying tumour initiation of testicular germ cell cancer. ( 24292446 )
2013
23
Thrombocytopenia following high-dose chemotherapy with carboplatin, etoposide and thiotepa in patients with testicular germ cell cancer. ( 23260006 )
2013
24
Changing epidemiologic features of testicular germ cell cancer in Germany: corroboration at population level. ( 24035419 )
2013
25
Association between polymorphisms in the aryl hydrocarbon receptor repressor gene and disseminated testicular germ cell cancer. ( 23420531 )
2013
26
Expression analysis of RNA-binding motif gene on Y chromosome (RBMY) protein isoforms in testis tissue and a testicular germ cell cancer-derived cell line (NT2). ( 23567846 )
2013
27
Genome-wide assessment of the association of rare and common copy number variations to testicular germ cell cancer. ( 23372565 )
2013
28
Targeted serum miRNA (TSmiR) test for diagnosis and follow-up of (testicular) germ cell cancer patients: a proof of principle. ( 24012110 )
2013
29
Influence of vitamin D on cisplatin sensitivity in testicular germ cell cancer-derived cell lines and in a NTera2 xenograft model. ( 23098692 )
2013
30
Sperm concentration, testicular volume and age predict risk of carcinoma in situ in contralateral testis of men with testicular germ cell cancer. ( 23770148 )
2013
31
Variants in KITLG predispose to testicular germ cell cancer independently from spermatogenic function. ( 22194441 )
2012
32
Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer. ( 22245602 )
2012
33
Replication of genetic susceptibility loci for testicular germ cell cancer in the Croatian population. ( 22745383 )
2012
34
Anti-tumour activity of two novel compounds in cisplatin-resistant testicular germ cell cancer. ( 23169338 )
2012
35
Is testicular germ cell cancer associated with increased muscle mass or adiposity? ( 21253772 )
2011
36
Perinatal risk factors for childhood testicular germ-cell cancer: a Nordic population-based study. ( 21846595 )
2011
37
Polymorphic variation in the androgen receptor gene: association with risk of testicular germ cell cancer and metastatic disease. ( 20880698 )
2011
38
Interdisciplinary evidence-based recommendations for the follow-up of early stage seminomatous testicular germ cell cancer patients. ( 21347634 )
2011
39
Interdisciplinary evidence-based recommendations for the follow-up of testicular germ cell cancer patients. ( 21346388 )
2011
40
Development of testicular germ cell cancer following successful infliximab induction therapy for ulcerative colitis. ( 21453887 )
2011
41
Heterozygous deletion at the RLN1 locus in a family with testicular germ cell cancer identified by integrating copy number variation data with phenome and interactome information. ( 21696394 )
2011
42
Testosterone deficiency in testicular germ-cell cancer patients is not influenced by oncological treatment. ( 21062302 )
2011
43
Canadian consensus guidelines for the management of testicular germ cell cancer. ( 20368885 )
2010
44
Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. ( 20543847 )
2010
45
Burden or relief: do second-opinion centers influence the quality of care delivered to patients with testicular germ cell cancer? ( 19931248 )
2010
46
Current status of chemotherapy in risk-adapted management for metastatic testicular germ cell cancer. ( 19922501 )
2010
47
Testicular germ cell cancer incidence in an immigration perspective, Denmark, 1978 to 2003. ( 20171682 )
2010
48
Familial coaggregation of cryptorchidism, hypospadias, and testicular germ cell cancer: a nationwide cohort study. ( 20026812 )
2010
49
Circulating mitochondrial DNA in the serum of patients with testicular germ cell cancer as a novel noninvasive diagnostic biomarker. ( 19154496 )
2009
50
Cell-free circulating DNA: diagnostic value in patients with testicular germ cell cancer. ( 19010497 )
2009

Variations for Testicular Germ Cell Cancer

Expression for Testicular Germ Cell Cancer

Search GEO for disease gene expression data for Testicular Germ Cell Cancer.

Pathways for Testicular Germ Cell Cancer

Pathways related to Testicular Germ Cell Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.71 AR PIAS1
2 10.13 ESR2 LHCGR

GO Terms for Testicular Germ Cell Cancer

Biological processes related to Testicular Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.56 AR DMRT1 ESR2 PIAS1
2 steroid hormone mediated signaling pathway GO:0043401 9.32 AR ESR2
3 androgen receptor signaling pathway GO:0030521 9.16 AR PIAS1
4 sex differentiation GO:0007548 8.96 AR DMRT1
5 male gonad development GO:0008584 8.92 AR DMRT1 KITLG LHCGR

Molecular functions related to Testicular Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.56 ALPP AR ESR2 PIAS1
2 steroid hormone receptor activity GO:0003707 9.16 AR ESR2
3 nuclear receptor activity GO:0004879 8.96 AR ESR2
4 steroid binding GO:0005496 8.62 AR ESR2

Sources for Testicular Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....