Testicular Germ Cell Tumor malady

MalaCards: Testicular Germ Cell Tumor is related to seminoma and germ cell tumor. An important gene associated with Testicular Germ Cell Tumor is TGCT1 (testicular germ cell tumor susceptibility 1), and among its related pathways are Pancreatic cancer and Breast Cancer Regulation by Stathmin1. The compounds vincristine and roscovitine have been mentioned in the context of this disorder. Affiliated tissues include testis, b cells and endothelial, and related mouse phenotypes are respiratory system and craniofacial.

testicular germ cell tumor 7 33 43

Diseases related to testicular germ cell tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 857)

id	Related Disease	Score	Top Affiliating Genes
1	seminoma	28.6	KIT, RB1, BRAF, RARB, BAX, CGA
2	germ cell tumor	25.6	LRP6, PDE11A, KIT, PCNA, BUB1B, GCNT1
3	carcinoma	18.0	LRP6, PDE11A, KIT, PCNA, BUB1B, GCNT1
4	neuronitis	16.5	LRP6, PDE11A, KIT, PCNA, GCNT1, RB1
5	endodermal sinus tumor	14.1	CGB, CGB5, INHA, ALPP, ALPPL2, TNFRSF8
6	central nervous system germinoma	14.1	CGB, ALPP, POU5F1
7	testicular neoplasm	14.0	KIT, INHA, FGFR3, ALPP, ALPPL2, STK10
8	extragonadal germ cell tumor	14.0	CGB, CGB5, GPC3, AFP
9	placental site trophoblastic tumor	14.0	CGA, CGB, CGB5, INHA
10	nonseminomatous germ cell tumor	14.0	CGA, CGB, CGB5, APAF1, AFP
11	mature teratoma	13.9	CGA, CGB, ALPP, AFP
12	malignant sertoli cell tumor	13.9	CGB5, ALPP, AFP
13	central nervous system germ cell tumor	13.9	CGB, PDPN, AFP
14	rectum cancer	13.9	BAX, APAF1, IFI27, TYMP
15	edwards syndrome	13.9	BIRC3, BCL10, CGA, INHA, AFP
16	birth defects	13.9	CGB5, SULT1A1, SULT1E1, CYP1A2, H19, AFP
17	adult t-cell leukemia	13.9	BCL10, CDKN2B, FAS, ANXA5, MAGEA1, MAGEA4
18	gonadal dysgenesis	13.9	CGB, CGB5, AZF1, DMRT1, WT1, TSPY1
19	complete androgen insensitivity syndrome	13.9	CGA, AR, ALPPL2, CYP19A1
20	gestational trophoblastic tumor	13.8	PCNA, CGA, CGB, CGB5, H19
21	acrocephalosyndactylia	13.8	FGF2, FGF4, FGFR1, FGFR3
22	anus basaloid carcinoma	13.8	CDKN1A, IFI27, ALPP, KRAS
23	dysgerminoma	13.8	KIT, CGA, CGB, CGB5, INHA, ENO2
24	follicular adenoma	13.8	BRAF, CDKN2B, CDH1, AR, IFI27, NME1
25	male infertility	13.8	CGA, AZF1, AR, ESR2, CYP19A1, TSPY1
26	gonadoblastoma	13.8	KIT, RB1, CGB, ALPP, ALPPL2, WT1
27	intestine carcinoma in situ	13.8	INHBC, APC, FAS, KRAS
28	mycetoma	13.7	CYP1B1, CYP17A1, CYP19A1, COMT
29	trophoblastic neoplasm	13.7	PCNA, CGA, CGB5, INHA
30	male pseudohermaphroditism due to defective lh	13.7	CGB5, AR, ALPP, CYP17A1, WT1
31	micropenis	13.7	CGA, CGB5, AR, IGFBP3, CYP17A1
32	cutaneous t cell lymphoma	13.7	BIRC5, BAX, CDKN2B, FAS, ANXA5, TNFRSF8
33	androgen insensitivity syndrome	13.7	CGA, AR, INHA, IGF2, ALPPL2, CYP19A1
34	germinoma	13.7	KIT, BAX, CGA, CGB, CGB5, CDH1
35	breast malignant phyllodes tumor	13.7	KIT, MKI67, CCNA2, IGF2
36	sex cord-gonadal stromal tumor	13.7	INHA, INHBA, ALPP, WT1
37	epithelioid trophoblastic tumor	13.7	CGA, CGB5, CDKN2A, INHA, ALPP
38	ovarian cyst	13.7	CGA, CGB5, ESR2, CYP19A1
39	sacrococcygeal teratoma	13.7	PCNA, CGA, POU5F1, AFP
40	sycp3-related pregnancy loss, susceptibility to	13.7	CGA, CGB, CGB5, GSTT1, ANXA5, CYP1A1
41	giant cell hepatitis	13.7	CYP1A1, CYP1A2, CYP1B1, CYP17A1
42	hepatic adenoma	13.7	PCNA, AR, APC, STK11
43	ovarian cancer	13.7	INHA, ALPP, KRAS, NME1
44	peripheral t-cell lymphoma	13.7	FGFR3, ETV6, TNFRSF8, PDGFRA, LTA, TCL1A
45	aorta atresia	13.7	XIAP, CGA, INHA, IGFBP3, CYP19A1
46	neural tube defect	13.7	CGA, CGB, CGB5, PDGFRA, AFP
47	antley-bixler syndrome	13.7	FGFR1, CYP1A2, CYP1B1, CYP17A1, CYP19A1
48	anaplastic plasmacytoma	13.7	PCNA, MKI67, IFI27, TNFRSF8
49	hodgkin's lymphoma	13.7	BIRC3, XIAP, CDKN2C, FGFR3, MDM2, MAGEA1
50	46, xy disorders of sexual development	13.7	RB1, AR, ALPPL2, DMRT1, CYP17A1, WT1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to testicular germ cell tumor:

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MGI Mouse Phenotypes related to testicular germ cell tumor:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.1	LRP6, CDKN2D, SOX5
2	craniofacial phenotype	MP:0005382	9.8	LRP6, KIT, LATS2, INHBA, INHBB, FGF8
3	endocrine/exocrine gland phenotype	MP:0005379	9.8	CDK6, CDKN2C, CDKN2B, CDKN2D, CDKN1B, FMR1
4	embryogenesis phenotype	MP:0005380	9.0	LRP6, KIT, BUB1B, BRAF, VHL, RARB
5	liver/biliary system phenotype	MP:0005370	8.9	LRP6, KIT, VHL, VEGFA, AR, INHBC
6	hematopoietic system phenotype	MP:0005397	8.1	KIT, PCNA, BUB1B, GCNT1, BRAF, VHL
7	no phenotypic analysis	MP:0003012	7.9	LRP6, PCNA, RB1, VEGFA, XIST, CDKN1B
8	hearing/vestibular/ear phenotype	MP:0005377	7.8	LRP6, KIT, RB1, RARB, BAX, CDKN1A
9	behavior/neurological phenotype	MP:0005386	7.8	LRP6, PDE11A, KIT, GCNT1, RB1, BRAF
10	renal/urinary system phenotype	MP:0005367	7.7	LRP6, KIT, GCNT1, BRAF, VHL, RARB
11	limbs/digits/tail phenotype	MP:0005371	7.7	LRP6, KIT, RB1, VHL, VEGFA, RARB
12	pigmentation phenotype	MP:0001186	7.6	KIT, RB1, BRAF, CDKN1B, CDKN2A, MDM2
13	normal phenotype	MP:0002873	7.5	LRP6, GCNT1, BRAF, VHL, VEGFA, RARB
14	nervous system phenotype	MP:0003631	7.2	LRP6, PDE11A, KIT, RB1, BRAF, BCL10
15	integument phenotype	MP:0010771	6.7	LRP6, KIT, BUB1B, RB1, BRAF, VHL
16	mortality/aging	MP:0010768	6.5	LRP6, RB1, BRAF, VHL, VEGFA, RARB
17	immune system phenotype	MP:0005387	6.3	KIT, BUB1B, GCNT1, BRAF, XIAP, XIST
18	adipose tissue phenotype	MP:0005375	6.2	LRP6, BUB1B, RB1, BRAF, CDKN1A, CDKN1B
19	reproductive system phenotype	MP:0005389	6.1	LRP6, BUB1B, VHL, VEGFA, RARB, XIST
20	skeleton phenotype	MP:0005390	5.7	LRP6, KIT, BUB1B, RB1, BRAF, VHL
21	digestive/alimentary phenotype	MP:0005381	5.7	LRP6, KIT, GCNT1, RB1, BRAF, VHL
22	growth/size phenotype	MP:0005378	5.6	LRP6, KIT, BUB1B, RB1, BRAF, VHL
23	vision/eye phenotype	MP:0005391	4.8	LRP6, KIT, BUB1B, RB1, BRAF, VEGFA
24	muscle phenotype	MP:0005369	3.7	KIT, BUB1B, RB1, BRAF, VHL, VEGFA
25	tumorigenesis	MP:0002006	3.3	KIT, BUB1B, RB1, BRAF, VHL, XRCC1
26	cardiovascular system phenotype	MP:0005385	2.4	KIT, RB1, BRAF, VHL, VEGFA, RARB
27	cellular phenotype	MP:0005384	2.2	LRP6, KIT, PCNA, BUB1B, GCNT1, RB1
28	homeostasis/metabolism phenotype	MP:0005376	0.9	LRP6, KIT, BUB1B, RB1, BRAF, VHL

Articles related to testicular germ cell tumor:

(show top 50)    (show all 114)

id	Title	Authors	Year	Affiliating Genes
1	APAF-1 is related to an undifferentiated state in the testicular germ cell tumor pathway. (20977544)	Behjati R.... Noguchi M.	2011	APAF1
2	MAGEC2 is a sensitive and novel marker for seminoma: a tissue microarray analysis of 325 testicular germ cell tumors. (21780320)	Bode P.K.... Moch H.	2011	MAGEC2
3	TCL1 protein expression in testicular germ cell tumor s. (20395523)	Lau S.K.... Chu P.G.	2010	TCL1A
4	Protein overexpression and gene amplification of epid ermal growth factor receptor in adult testicular germ cell tumors: potential ro le in tumor progression. (20608935)	Miyai K.... Tsuda H.	2010	EGFR
5	p53 inactivation by MDM2 and MDMX negative feedback l oops in testicular germ cell tumors. (20372076)	Li B.... Chen J.	2010	MDM2, TP53, MDM4
6	Differential expression of SOX2 and SOX17 in testicular germ cell tumors. (19369635)	Nonaka D.	2009	SOX17, SOX8
7	High DNA methyltransferase 3B expression mediates 5-a za-deoxycytidine hypersensitivity in testicular germ cell tumors. (19951990)	Beyrouthy M.J.... Spinella M.J.	2009	DNMT3B
8	Mutational analysis of proto-oncogene Dbl on Xq27 in testicular germ cell tumors reveals a rare SNP in a patient with bilateral unde scended testis. (19373475)	Xu W.H.... Sun D.J.	2009	MCF2
9	Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors. (19417025)	Castillo-Avila W.... ViA+als F.	2009	PDGFRA
10	Insulin-like growth factor 1, insulin-like growth factor-binding protein 3, and testicular germ-cell tumor risk. (18408226)	Chia V.M.... McGlynn K.A.	2008	IGFBP3
11	Risk of testicular germ cell tumors and polymorphisms in the insulin-like growth factor genes. (18349294)	Chia V.M.... McGlynn K.A.	2008	IGF1R, IGF1, IGF2
12	Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors. (18069663)	Linger R.... Rapley E.A.	2008	DND1
13	A case-control investigation of immune function gene polymorphisms and risk of testicular germ cell tumors. (17220333)	Purdue M.P.... McGlynn K.A.	2007	TGFB1, TNF, IL10
14	The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors. (17521702)	Li Y.... Lau Y.F.	2007	CCNB1, POU5F1, ALPPL2
15	Association of BCL10 germ line polymorphisms on chromosome 1p with advanced stage testicular germ cell tumor patients. (16229939)	Inoue T.... Habuchi T.	2006	BCL10
16	Association of XRCC1 gene polymorphisms with the susceptibility and chromosomal aberration of testicular germ cell tumors. (16596238)	Tsuchiya N.... Habuchi T.	2006	XRCC1
17	A genome-wide study of allelic imbalance in human testicular germ cell tumors using microsatellite markers. (16364756)	Bergthorsson J.T.... Barkardottir R.B.	2006	WT1, ETV6
18	Glypican 3: a novel marker in testicular germ cell tumors. (17122513)	Zynger D.L.... Yang X.J.	2006	GPC3
19	Down-regulation of FAK and IAPs by laminin during cisplatin-induced apoptosis in testicular germ cell tumors. (16391810)	Andjilani M.... Tabone E.	2006	XIAP, BIRC3
20	Absence of constitutional Y chromosome AZF deletions in patients with testicular germ cell tumors. (15667903)	Lutke Holzik M.F.... Hoekstra H.J.	2005	AZF1
21	Activating mutations and/or expression levels of tyrosine kinase receptors GRB7, RAS, and BRAF in testicular germ cell tumors. (16354586)	McIntyre A.... Shipley J.	2005	BRAF, KRAS, GRB7
22	A c-KIT codon 816 mutation, D816H, in the testicular germ cell tumor: case report of a Japanese patient with bilateral testicular seminomas. (15902997)	Tate G.... Mitsuya T.	2005	KIT
23	Microsatellite instability and loss of heterozygosity have distinct prognostic value for testicular germ cell tumor recurrence. (15492498)	Velasco A.... Leach F.S.	2004	MSH2
24	Resistance to platinum-containing chemotherapy in testicular germ cell tumors is associated with downregulation of the protein kinase SRPK1. (15256051)	Schenk P.W.... Nooter K.	2004	SRPK1
25	Chromosomes, genes, and development of testicular germ cell tumors. (15172750)	von Eyben F.E.	2004	CDKN1A, CCND2, CDKN2D
26	Mismatch repair gene expression and genetic instability in testicular germ cell tumor. (15467433)	Velasco A.... Leach F.S.	2004	MSH2, MLH1
27	Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors. (15361850)	Kato Y.... Tsuruo T.	2004	PDPN
28	Low dose carboplatin combined with angiostatic agents prevents metastasis in human testicular germ cell tumor xenografts. (14501775)	Abraham D.... Aharinejad S.	2003	THBS1
29	NKX3.1 expression is lost in testicular germ cell tumors. (14633588)	Skotheim R.I.... Saatcioglu F.	2003	NKX3-1
30	Loss of Fhit expression in testicular germ cell tumors and intratubular germ cell neoplasia. (12379753)	Eyzaguirre E.... Gatalica Z.	2002	FHIT
31	Expression patterns of cancer testis antigens in testicular germ cell tumors and adjacent testicular tissue. (11342977)	Yuasa T.... Okada Y.	2001	SSX2, PAGE4, CTAG2
32	BCL10 is not a major target for frequent loss of 1p in testicular germ cell tumors. (11376806)	Kakinuma H.... Kato T.	2001	BCL10
33	Clinical study of testicular germ cell tumors. (11496394)	Tomomasa H.... Yazaki T.	2001	CGB
34	High-dose chemotherapy with peripheral blood stem cell autotransplantation for patients with poor-risk testicular germ cell tumors--pilot study of the Japan Blood Cell Transplantation Study Group (10637748)	Nakagawa S.... Yoshida O.	1999	CGB
35	mdm-2 expression in human testicular germ-cell tumors and its clinical value. (10629640)	Eid H.... Bak M.	1999	MDM2
36	Expression of vascular endothelial growth factor in patients with testicular germ cell tumors as an indicator of metastatic disease. (10189138)	Fukuda S.... Ohi Y.	1999	VEGFA, TYMP
37	Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors. (9554401)	Heidenreich A.... Srivastava S.	1998	CDKN2B
38	Identification of the critical region of 12p over-rep resentation in testicular germ cell tumors of adolescents and adults. (9632138)	Mostert M.C.... Looijenga L.H.	1998	SOX5
39	Bax upregulation is an early event in cisplatin-induced apoptosis in human testicular germ-cell tumor cell line NT2, as quantitated by flow cytometry. (9041117)	Boersma A.W.... Stoter G.	1997	BAX, ANXA5
40	Frequent p16INK4 (MTS1) gene inactivation in testicular germ cell tumors. (9284835)	Chaubert P.... Shaw P.	1997	CDK4
41	Effective administration of recombinant granulocyte colony-stimulating factor to prevent granulocytopenia due to combination chemotherapy for testicular germ cell tumors (8918674)	Nonomura K.... Adachi Y.	1996	CSF3
42	Detection of recurrence in patients with clinical stage I nonseminomatous testicular germ cell tumors and consequences for further follow-up: a single-center 10-year experience. (7537802)	Gels M.E.... Schraffordt Koops H.	1995	CGA
43	N- and KRAS mutations in primary testicular germ cell tumors: incidence and possible biological implications. (7535083)	Olie R.A.... Oosterhuis J.W.	1995	KRAS
44	Glutathione related enzymes in human testicular germ cell tumors and normal testes. (7654023)	Institoris E.... Bak M.	1995	GSR
45	Proliferating cell nuclear antigen expression to predict occult disease in clinical stage I nonseminomatous testicular germ cell tumors. (7915335)	Fernandez E.B.... Moul J.W.	1994	PCNA
46	Management of contralateral testicular intraepithelia l neoplasia in patients with testicular germ-cell tumor. (7951338)	Dieckmann K.P.... Loy V.	1994	ALPP
47	Biallelic expression of the H19 and IGF2 genes in human testicular germ cell tumors. (8021956)	van Gurp R.J.... Looijenga L.H.	1994	H19
48	Expression of the hst-1 and c-kit protooncogenes in human testicular germ cell tumors. (1706218)	Strohmeyer T.... Slamon D.J.	1991	FGF3
49	The role of alkaline phosphatase isoenzymes as tumor markers for testicular germ cell tumors. (1711586)	Koshida K.... Andersson L.	1991	CGB
50	An immunohistochemical study on neuron specific enolase in testicular germ cell tumors (1645819)	UjiAc T.... Monma N.	1991	ENO2

Genes related to testicular germ cell tumor according to GeneCards:

(show top 50)    (show all 159)

id	Symbol	Description	Score	GeneCards Section Context
1	TGCT1	testicular germ cell tumor susceptibility 1	11.1	Aliases & Descriptions
2	MCFD2	multiple coagulation factor deficiency 2	11.0	Summaries
3	MIR372	microRNA 372	11.0	Publications
4	MIR371A	microRNA 371a	11.0	Publications
5	MIR373	microRNA 373	11.0	Publications
6	DND1	dead end homolog 1 (zebrafish)	11.0	Publications
7	DPPA3	developmental pluripotency associated 3	11.0	Expressions
8	PHLDA3	pleckstrin homology-like domain, family A, member 3	11.0	Publications
9	INHBE	inhibin, beta E	11.0	Publications
10	PAGE4	P antigen family, member 4 (prostate associated)	11.0	Publications
11	PRSS21	protease, serine, 21 (testisin)	11.0	Publications
12	TSPY1	testis specific protein, Y-linked 1	11.0	Publications
13	SOX8	SRY (sex determining region Y)-box 8	11.0	Publications
14	MAGEC2	melanoma antigen family C, 2	11.0	Publications
15	INHBC	inhibin, beta C	11.0	Publications
16	SOX17	SRY (sex determining region Y)-box 17	11.0	Publications
17	CTAG2	cancer/testis antigen 2	11.0	Publications
18	ESX1	ESX homeobox 1	11.0	Expressions
19	XIST	X (inactive)-specific transcript (non-protein coding)	11.0	Publications
20	CDKN2D	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	11.0	Publications
21	PLA2G16	phospholipase A2, group XVI	11.0	Publications, Expressions
22	NKX3-1	NK3 homeobox 1	11.0	Publications
23	PRSS8	protease, serine, 8	11.0	Publications
24	SLC43A1	solute carrier family 43, member 1	11.0	UniProt Related
25	HSD17B1	hydroxysteroid (17-beta) dehydrogenase 1	11.0	Publications
26	AZF1	azoospermia factor 1	11.0	Publications
27	HIC1	hypermethylated in cancer 1	11.0	Publications
28	TRO	trophinin	11.0	Publications
29	IGFALS	insulin-like growth factor binding protein, acid labile subunit	11.0	Publications
30	SSX2	synovial sarcoma, X breakpoint 2	11.0	Publications
31	H19	H19, imprinted maternally expressed transcript (non-protein coding)	11.0	Publications
32	GRB7	growth factor receptor-bound protein 7	11.0	Publications
33	INHBB	inhibin, beta B	11.0	Publications
34	FGF4	fibroblast growth factor 4	11.0	Publications
35	FGF3	fibroblast growth factor 3	11.0	Publications
36	MAGEA4	melanoma antigen family A, 4	11.0	Publications
37	CGB	chorionic gonadotropin, beta polypeptide	11.0	Publications
38	PRAME	preferentially expressed antigen in melanoma	11.0	Publications
39	TCL1A	T-cell leukemia/lymphoma 1A	11.0	Publications
40	TRIM27	tripartite motif containing 27	11.0	Publications
41	BIRC7	baculoviral IAP repeat containing 7	11.0	Publications
42	STK17A	serine/threonine kinase 17a	11.0	Publications
43	ALPPL2	alkaline phosphatase, placental-like 2	11.0	Publications
44	CCND2	cyclin D2	11.0	Publications
45	BCL10	B-cell CLL/lymphoma 10	11.0	Publications
46	SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	11.0	Publications
47	INHBA	inhibin, beta A	11.0	Publications
48	ENTPD5	ectonucleoside triphosphate diphosphohydrolase 5	11.0	Publications
49	IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	11.0	Publications
50	MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	11.0	Publications

Pathways related to testicular germ cell tumor according to GeneDecks:

(show top 50)    (show all 185)

id	Pathway	Score	Top Affiliating Genes
1	Pancreatic cancer20	10.6	CDK6
2	Breast Cancer Regulation by Stathmin136	10.4	CCNB1, IGF1R, EGFR, CCNE1, GRB7, FGF2
3	Estrogen Metabolism Pathway34	10.4	HSD17B1, CYP1B1, SULT1E1, SULT1A1, CYP1A2, CYP19A1
4	DNA damage ATM/ATR regulation of G1/S checkpoint10	10.4	CCND2, CCNA2, CCNE1, CDK2, CDK4, MDM2
5	Colorectal cancer20	10.1	BRAF, TGFB1, MSH2
6	Cell cycle_Cell cycle (generic schema)41	9.9	CDK6, CDK2, CDK4, RB1, CCND2, CCNA2
7	Cell cycle Cell cycle (generic schema)10	9.9	CCND1, CDK4, CDK6, RB1, CCNA2, CCNB1
8	Selected targets of Oct-3/410	9.8	DNMT3A, CGB, PDGFRA, TCL1A, POU5F1, DNMT3B
9	Non-small cell lung cancer20	9.5	RB1, CDK6, CDK4, FHIT, KRAS, BRAF
10	Cell Cycle, Mitotic38	9.3	MAD2L1, CDKN1B, CDKN2D, RB1, CDK2, PCNA
11	Cell cycle ESR1 regulation of G1/S transition10	9.3	CCNE1, ESR1, CCND1, CCNA2, CDK4, CDKN1B
12	Cell cycle_ESR1 regulation of G1/S transition41	9.3	CDK2, CDKN1A, CDK6, CCNA2, RB1, CDKN1B
13	GADD45 Pathway36	9.2	CCND1, PCNA, CDK6, CDKN1A, CDK2, CDK4
14	DNA damage_ATM/ATR regulation of G1/S checkpoint41	9.1	CCNE1, CCNA2, CCND2, CCND1, TP53, CDK4
15	Estrogen-mediated S-Phase Entry36	9.1	RB1, CDK2, CDKN1B, CDK4, CCNE1, CCNA2
16	p53 Signaling36	9.1	THBS1, TP53, CASP8, CASP3, CCNE1, MDM2
17	Apoptosis and survival_Caspase cascade41	8.9	FAS, FADD, APAF1, XIAP, BAX, TNF
18	Akt Signaling36	8.9	KIT, LTA, PDGFRA, TNFRSF8, TNF, FGF4
19	Apoptosis and survival Caspase cascade10	8.9	TNF, CASP8, IGF1, IGF1R, FAS, FADD
20	Small cell lung cancer20	8.9	BIRC3, CDK2, TP53, CDKN2B, CDKN1B, CDK4
21	Telomerase Components in Cell Signaling36	8.8	FLT1, FGF4, FGF8, RB1, KIT, FGFR1
22	Cell cycle Regulation of G1/S transition (part 1)10	8.6	CDK2, TGFB1, SMAD4, CDK6, CCND1, CCND2
23	Cell cycle_Regulation of G1/S transition (part 1)41	8.6	CCND2, CCND1, TGFB1, CDK6, CDKN1A, CDKN2B
24	Glioblastoma Multiforme36	8.6	CDKN1B, CDK4, MDM2, APC, CCNE1, IGF1R
25	Apoptosis Signaling Pathways37	8.6	CASP8, BIRC5, BIRC7, BAX, XIAP, CDKN1A
26	Nanog in Mammalian ESC Pluripotency36	8.6	FLT1, FGF2, FGF4, FGF8, FGFR1, APC
27	eNOS Signaling36	8.6	CASP8, ESR1, ESR2, PDGFRA, EGFR, TGFB1
28	DHA Signaling36	8.4	FLT1, FGF2, FGF4, BAX, CASP3, KIT
29	Bladder cancer20	8.3	BRAF, VEGFA, CDKN1A, CDKN2A, CDK4, CDH1
30	G1-S Phase Transition36	8.2	RB1, CDK6, TGFB1, CDKN1A, CDKN2C, CDK2
31	Cyclins and Cell Cycle Regulation36	8.1	CDK2, CDKN2B, CDKN2D, CDKN1B, CDKN2A, CDK4
32	Chronic myeloid leukemia20	8.0	TP53, SMAD4, CDK4, MDM2, CCND1, CDKN1B
33	Prostate cancer20	8.0	GSTP1, AR, CDKN1B, CDK2, CDKN1A, BRAF
34	Glioma20	8.0	EGFR, KRAS, PDGFRA, TP53, IGF1, IGF1R
35	Cell Cycle / Checkpoint Control3	8.0	PCNA, BUB1B, RB1, LATS2, XRCC1, CCNB1
36	p53 Mediated Apoptosis36	8.0	KIT, BAX, FLT1, FGF2, FGF4, FGF8
37	Cell cycle20	7.9	CDKN2A, CDK4, MDM2, MAD2L1, CCNE1, CCNB1
38	ERK Signaling36	7.7	TGFB1, PDGFRA, IL10, EGFR, ESR2, ESR1
39	p53 signaling pathway20	7.7	CCNE1, CCNB1, CCND2, CCND1, IGFBP3, IGF1
40	Melanoma20	7.7	FGF2, CDH1, CDK4, CDKN2A, CDKN1A, CDK6
41	Apoptotic Pathways in Synovial Fibroblasts36	7.6	IGF1R, IGF2, IGF1, CASP8, TP53, TNF
42	Cytokine-cytokine receptor interaction20	7.6	TNFRSF8, CSF3, TGFB1, LTA, EGFR, TNF
43	Mitochondrial Apoptosis36	7.5	FGF4, TGFB1, EGFR, FGF8, FGFR1, FGFR3
44	Colorectal Cancer Metastasis36	7.4	BAX, IFNGR2, MSH2, TNF, TP53, LRP6
45	PAK Pathway36	7.0	CASP3, CASP8, TNF, PDGFRA, LTA, EGFR
46	Pancreatic Adenocarcinoma36	6.9	CDK4, FLT1, FGF2, FGF4, FGF8, FGFR1
47	Cellular Apoptosis Pathway36	6.7	KIT, BAX, CDKN2A, FLT1, FGF2, FGF4
48	Pathways in cancer20	6.3	FADD, MDM2, FGFR3, FGFR1, FGF4, FGF3
49	p38 Signaling36	6.2	LTA, EGFR, TGFB1, FGF4, FGF8, FGFR1
50	Molecular Mechanisms of Cancer36	6.0	CDKN2B, CDKN2D, CDKN1B, CDKN2A, CDK4, CDH1

Compounds related to testicular germ cell tumor according to GeneDecks:

(show top 50)    (show all 421)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.5	KIT, CGB, CGB5, FGF2, ANXA5, MAD2L1
2	roscovitine32	10.4	PCNA, BIRC5, XIAP, CCNB1, CCNA2, IFI27
3	dmso32	10.4	CGA, CGB5, ALPP, TERC, CYP1B1, KRT18
4	h2o232	10.3	CGA, CGB5, APAF1, ANXA5, CCNB1, IGF1R
5	egcg32	10.2	XIAP, CDK6, CDK2, IGFBP3, SULT1A1, KRT18
6	sp 60012532 42	10.7	BIRC3, CDKN1A, CASP3, TP53
7	p00232	9.5	KIT, RB1, BRAF, BIRC5, XRCC1, CDH1
8	mitomycin c32	9.5	PCNA, RB1, BIRC5, XIAP, GSR, FGF2
9	mifepristone32 42 9 9	12.4	BIRC5, BAX, CGA, CGB, CGB5, CDK2
10	fludarabine32 9 9	11.3	BIRC3, BIRC5, BAX, XIAP, CDK2, CDKN1B
11	benzo(a)pyrene32	9.0	RB1, RARB, XRCC1, CDKN1A, CDK4, GSTM1
12	rapamycin32 42	9.9	KIT, RB1, BRAF, VHL, VEGFA, CDK6
13	arginine32	8.9	BRAF, RARB, XRCC1, CGA, CGB5, CDK2
14	erlotinib32 34 9 9	11.8	KIT, VEGFA, BIRC5, CDKN1B, CDH1, CCND1
15	cyclosporin a32 42	9.8	CGA, CGB5, CDK2, CDK4, FHIT, FGF2
16	sulindac32 9 9	10.7	PCNA, BIRC5, BAX, XIAP, CDKN1A, CDH1
17	sodium bisulfite32	8.7	RARB, CDKN2B, CDKN2A, CDH1, MLH1, FMR1
18	o6-methylguanine32	8.5	PCNA, BRAF, RARB, MSH2, CDKN2B, CDKN2A
19	bromodeoxyuridine32	8.4	PCNA, RB1, CDKN1A, CDK2, CDKN1B, CDK4
20	agarose32	8.4	KIT, BAX, XIAP, CDKN1A, CDKN2A, MLH1
21	cysteine32	8.3	LRP6, PCNA, RARB, XIAP, CGB, CDKN2A
22	crcs32	8.3	RB1, BRAF, BIRC5, MSH2, CDKN2A, CDH1
23	eb 108932	8.3	PCNA, BAX, CDK6, CDKN1A, CDK2, CDKN1B
24	gefitinib32 34 9 9	11.1	KIT, VEGFA, BIRC5, CDK6, CDKN1A, CDK2
25	alanine32	8.0	PCNA, BRAF, BIRC3, BIRC5, BCL10, CGA
26	folate32	7.9	VHL, XRCC1, CGA, CGB5, CDKN2A, CDH1
27	n acetylcysteine32	7.9	PCNA, BIRC5, CDKN1A, CDKN1B, CDKN2A, CDK4
28	n-(4-hydroxyphenyl)retinamide32	7.8	RB1, RARB, BAX, CDKN1A, CDK4, ANXA5
29	camptothecin32 42 9 9	10.8	PCNA, RB1, BIRC5, BAX, XRCC1, XIAP
30	creatinine32	7.7	PCNA, XRCC1, CGA, CGB, CGB5, CDK2
31	lactacystin32	7.7	BIRC5, CDKN1A, CDK2, CDKN1B, CDK4, AR
32	irinotecan32 34 9 9	10.6	KIT, BRAF, VEGFA, BAX, XRCC1, CDKN1A
33	mg 13232 42	8.5	PCNA, BIRC3, BIRC5, BAX, XIAP, CDKN1A
34	imatinib32 34 9 9	10.3	KIT, BRAF, VEGFA, BIRC5, XIAP, CDKN1A
35	indole-3-carbinol32	7.1	BIRC5, BAX, XIAP, CDK6, CDKN1A, CDK2
36	adriamycin32	7.0	RB1, BIRC3, BIRC5, BAX, XIAP, CDKN1A
37	etoposide32 42 9 9	10.0	PCNA, RB1, BIRC3, BIRC5, BAX, XRCC1
38	vitamin d32	6.9	RARB, CGA, CDKN1A, CDK2, CDK4, CDH1
39	resveratrol32 9 18 9	9.9	PCNA, RB1, VEGFA, BIRC5, BAX, XIAP
40	estrogen32	6.8	PCNA, VHL, RARB, CGA, CGB, CGB5
41	progesterone32 42 9 18 9	10.7	KIT, PCNA, RB1, BRAF, RARB, BIRC5
42	tgf beta132	6.6	CDK6, CDKN1A, CDK2, CDKN2B, CDKN1B, CDK4
43	thymidylate32	6.4	PCNA, RB1, VEGFA, BIRC5, BAX, XRCC1
44	docetaxel32 34 9 9	9.4	KIT, VEGFA, BIRC5, BAX, XIAP, CDKN1A
45	doxorubicin32 34 9 9	9.0	KIT, BUB1B, BIRC3, XIAP, CGA, CGB5
46	5fluorouracil32	5.3	KIT, PCNA, RB1, VEGFA, BIRC3, BIRC5
47	butyrate32	5.2	PCNA, RB1, BIRC5, BAX, XIAP, CDK6
48	genistein32 9 18 9	7.6	PCNA, RB1, VEGFA, RARB, BIRC5, BAX
49	retinoic acid32 42 18	6.1	KIT, RB1, BRAF, RARB, BIRC5, BAX
50	paclitaxel32 34 9 9	6.8	KIT, PCNA, BUB1B, RB1, BRAF, VEGFA

Cellular components related to testicular germ cell tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	death-inducing signaling complex	GO:031264	10.3	CASP8, FAS, FADD
2	CD95 death-inducing signaling complex	GO:031265	10.0	FAS, FADD, CASP8
3	cyclin-dependent protein kinase holoenzyme complex	GO:000307	9.6	CDK6, CCND1, CCND2, CCNE1, CDK4, CDK2
4	nucleoplasm	GO:005654	7.0	CDKN1B, CDK2, CDKN1A, XRCC1, RARB, VHL
5	extracellular space	GO:005615	6.9	FGF2, FLT1, VEGFA, GCNT1, KIT, IGFBP3
6	cytosol	GO:005829	6.0	CDKN1B, CDKN2D, CDKN2B, FGFR1, CDKN2A, CDK4
7	cytoplasm	GO:005737	5.4	TRO, TP53, TNFRSF8, SULT1E1, SRPK1, SMAD4
8	nucleus	GO:005634	3.8	FLT1, CCNE1, CCNB1, CCNA2, CCND2, CCND1

Biological processes related to testicular germ cell tumor according to GeneDecks:

(show top 50)    (show all 77)

id	Name	GO ID	Score	Top Affiliating Genes
1	estrogen metabolic process	GO:008210	10.7	CYP1B1, SULT1A1, HSD17B4, COMT, SULT1E1, HSD17B1
2	ovarian follicle development	GO:001541	10.6	CCND2, ESR2, INHBB, INHBA, INHA, KIT
3	male gonad development	GO:008584	10.4	SOX8, KIT, MSH2, WT1, CYP19A1, DMRT1
4	activation of pro-apoptotic gene products	GO:008633	10.4	FAS, IFI27, CASP8, NKX3-1, FADD, BAX
5	regulation of cyclin-dependent protein kinase activity	GO:000079	10.3	CDKN2D, CCNE1, CCNB1, CDKN2B, CCNA2, CDKN1B
6	positive regulation of phospholipase C activity	GO:010863	10.3	FGF2, PDGFRA, FGFR1, FLT1, KIT
7	insulin receptor signaling pathway	GO:008286	10.3	STK11, KRAS, IGF1R, FGFR3, FGFR1, FGF8
8	fibroblast growth factor receptor signaling pathway	GO:008543	10.2	MDM2, KRAS, FGFR3, FGF4, FGFR1, FGF8
9	negative regulation of epithelial cell proliferation involved in prostate gland development	GO:060770	10.2	NKX3-1, CDKN1B, APC, STK11
10	negative regulation of phosphorylation	GO:042326	10.1	CDKN2C, CDKN1B, CDKN2D, CDKN1A, CDKN2A, INHA
11	positive regulation of cell division	GO:051781	9.9	FGF3, FGF2, TGFB1, APC, NKX3-1, VEGFA
12	xenobiotic metabolic process	GO:006805	9.9	CYP19A1, SULT1A1, COMT, GSTP1, GSTM1, CYP1A1
13	positive regulation of MAPK cascade	GO:043410	9.8	IGF1, IGF2, KIT, FLT1, AR, FGFR1
14	negative regulation of epithelial cell proliferation	GO:050680	9.8	LRP6, AR, CDK6, CDKN2B, ESR2, TGFB1
15	cell division	GO:051301	9.8	CCND1, CCND2, BUB1B, CCNE1, CCNA2, BIRC5
16	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	9.8	FGFR3, FGF2, PDGFRA, KIT, FLT1, TGFB1
17	protein autophosphorylation	GO:046777	9.7	FGFR1, FGFR3, IGF1R, PDGFRA, STK10, STK11
18	response to estradiol stimulus	GO:032355	9.7	CCND2, ETS1, CYP19A1, TGFB1, CASP8, CCNE1
19	phosphatidylinositol-mediated signaling	GO:048015	9.6	PDGFRA, CDKN1B, FGFR1, MDM2, IGF1R, BUB1B
20	G1 phase of mitotic cell cycle	GO:000080	9.5	CDKN2C, CDK4, CDKN2A, CDK6, CDKN1A, RB1
21	negative regulation of cyclin-dependent protein kinase activity	GO:045736	9.4	APC, CDKN2A, LATS2, CDKN1A, CASP3, CDKN1B
22	positive regulation of mitosis	GO:045840	9.4	DMRT1, FGF8, AURKA, TNF, IGF1, IGF2
23	induction of apoptosis by intracellular signals	GO:008629	9.4	XIAP, CDKN1A, TP53, CASP8, BAX, APAF1
24	protein phosphorylation	GO:006468	9.4	STK11, BIRC5, BRAF, LATS2, AURKA, SRPK1
25	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.2	CDKN2A, NKX3-1, CASP8, IFI27, CDKN1B, APAF1
26	G1/S transition of mitotic cell cycle	GO:000082	9.1	CCNB1, INHBA, CCND1, CDK4, CDKN1B, CDKN2D
27	positive regulation of cell migration	GO:030335	9.1	FLT1, CGA, GRB7, IGF1R, ETS1, PDGFRA
28	cell cycle checkpoint	GO:000075	9.0	CDK2, CCNB1, MAD2L1, TP53, BUB1B, RB1
29	mitotic cell cycle	GO:000278	8.9	CCNB1, CCND1, CCNA2, CDK4, CDKN1A, CDKN2B
30	positive regulation of fibroblast proliferation	GO:048146	8.9	CDKN1A, PDGFRA, IGF1, CDK4, CDK6, EGFR
31	Ras protein signal transduction	GO:007265	8.8	FGF2, TP53, RB1, CDKN1A, CDK2, CDKN2A
32	anti-apoptosis	GO:006916	8.8	THBS1, ETS1, IGF1, IGF1R, ANXA5, TNF
33	signal transduction	GO:007165	8.7	CGB, TNFRSF8, PDPN, LTA, EGFR, ESR2
34	positive regulation of apoptotic process	GO:043065	8.7	ESR2, TNF, TNFRSF8, STK17A, TP53, IGFBP3
35	negative regulation of cell growth	GO:030308	8.7	CDKN1A, TGFB1, SMAD4, TP53, TRO, ESR2
36	positive regulation of protein phosphorylation	GO:001934	8.6	VEGFA, TGFB1, KRAS, TNF, IGF2, CCND1
37	positive regulation of MAP kinase activity	GO:043406	8.6	VEGFA, FLT1, TNF, EGFR, TGFB1, KRAS
38	MAPK cascade	GO:000165	8.6	TGFB1, FGF8, EGFR, KRAS, TNF, FGFR1
39	cell cycle arrest	GO:007050	8.5	CDKN2A, APC, CDK6, STK11, TGFB1, THBS1
40	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.5	FGFR1, ESR2, VHL, SOX17, DNMT3A, DNMT3B
41	response to hypoxia	GO:001666	8.4	VEGFA, XRCC1, FAS, ETS1, TNF, SMAD4
42	apoptotic process	GO:006915	8.3	CASP3, MDM4, PRAME, CDH1, MSH2, CGB
43	induction of apoptosis	GO:006917	8.2	INHA, ETS1, BCL10, BAX, CDKN2A, CDKN2C
44	response to drug	GO:042493	7.7	LTA, TGFB1, MSH2, CDKN1A, CDK4, COMT
45	positive regulation of cell proliferation	GO:008284	7.6	KIT, VEGFA, BIRC5, CSF3, PRAME, TGFB1
46	negative regulation of apoptotic process	GO:043066	7.5	SOD2, XIAP, VEGFA, BRAF, PRAME, CDKN1A
47	negative regulation of transcription, DNA-dependent	GO:045892	7.3	TGFB1, PRAME, NKX3-1, SOX8, SOX5, BIRC5
48	positive regulation of transcription, DNA-dependent	GO:045893	7.0	SMAD4, BCL10, CDK2, RB1, VHL, FGF2
49	negative regulation of cell proliferation	GO:008285	6.8	IGF1, NME1, NKX3-1, SOD2, STK11, TGFB1
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.5	ESR1, ETS1, IGF1, LRP6, RB1, VEGFA

Molecular functions related to testicular germ cell tumor according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:005179	10.2	INHA, INHBB, CGA, INHBA, CGB, INHBC
2	fibroblast growth factor binding	GO:017134	10.2	THBS1, FGFR3, FGF2, FGFR1
3	estrogen receptor activity	GO:030284	9.8	ESR1, ESR2, NKX3-1
4	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.8	KIT, FLT1, TRIM27, EGFR, PDGFRA
5	transcription factor binding	GO:008134	9.5	RB1, TP53, VHL, BCL10, CDKN2A, NKX3-1
6	cyclin-dependent protein kinase inhibitor activity	GO:004861	9.5	CDKN2A, CDKN2D, CDKN2B, CDKN2C, CDKN1A, CASP3
7	protein kinase binding	GO:019901	9.1	CCNE1, CDKN2D, CDKN2C, MSH2, TP53, CCND1
8	growth factor activity	GO:008083	9.0	FGF2, INHBE, INHBC, INHBA, INHA, VEGFA
9	protein homodimerization activity	GO:042803	9.0	VEGFA, BAX, BIRC5, KIT, MSH2, LRP6
10	cytokine activity	GO:005125	8.8	LTA, VEGFA, INHBA, INHBB, FGF2, IL10
11	transcription regulatory region DNA binding	GO:044212	8.4	WT1, TNF, TP53, AR, SMAD4, SOX17
12	identical protein binding	GO:042802	8.0	IGF1R, PCNA, FLT1, GRB7, MDM2, FADD
13	protein heterodimerization activity	GO:046982	8.0	TGFB1, EGFR, TP53, ENO2, INHBA, INHA
14	enzyme binding	GO:019899	7.9	BIRC5, ESR2, TP53, CYP1A2, EGFR, TGFB1
15	protein binding	GO:005515	1.6	INHBA, MAGEA1, MAGEC2, MAGEA4, CCNE1, CCNB1