MCID: TST021
MIFTS: 70

Testicular Germ Cell Tumor

Categories: Genetic diseases, Rare diseases, Cancer diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Testicular Germ Cell Tumor

MalaCards integrated aliases for Testicular Germ Cell Tumor:

Name: Testicular Germ Cell Tumor 53 49 71 69
Spermatocytic Seminoma 55 71 69
Male Germ Cell Tumor 53 71 69
Embryonal Cell Carcinoma 71 69
Endodermal Sinus Tumor 55 71
Testicular Teratoma 55 51
Yolk Sac Tumor 55 69
Seminoma 71 69
Tgct 53 71
Mgct 53 71
Malignant Testicular Non-Seminomatous Germ Cell Tumor 69
Testicular Non-Dysgerminomatous Germ Cell Tumor 55
Non-Dysgerminomatous Germ Cell Tumor of Testis 55
Testicular Non Seminomatous Germ Cell Tumor 55
Testicular Non-Seminomatous Germ Cell Tumor 69
Non-Seminomatous Germ Cell Tumor of Testis 55
Testicular Seminomatous Germ Cell Tumor 55
Seminomatous Germ Cell Tumor of Testis 55
Nonseminomatous Germ Cell Tumors 71
Germ Cell Tumor, Nonseminomatous 28
Spermatocytic Seminoma, Somatic 53
Nonseminomatous Germ Cell Tumor 69
Male Germ Cell Tumor, Somatic 53
Male Germ Cell Tumor; Mgct 53
Germ Cell Tumors, Somatic 53
Testicular Tumor, Somatic 53
Germ Cell Tumor of Testis 49
Teratoma of the Testis 55
Testicular Seminoma 55
Teratoma Testicular 71
Seminoma of Testis 55
Teratoma of Testis 69

Characteristics:

Orphanet epidemiological data:

55
testicular seminomatous germ cell tumor
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-5/10000 (Europe); Age of onset: Adult; Age of death: adult,elderly,young Adult;
non-seminomatous germ cell tumor of testis
Prevalence: 1-9/100000 (Europe),1-5/10000 (Europe);
testicular teratoma
Prevalence: <1/1000000 (Europe);
spermatocytic seminoma
Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult; Age of death: normal life expectancy;

OMIM:

53
Inheritance:
somatic mutation

Miscellaneous:
two subtypes - seminoma and nonseminoma
occasionally germ cell tumor arise from extra gonadal site (e.g., mediastinum, retroperitoneum, pineal gland)
most common cancer in men aged 15-40 years
highest incidence in men of european descent
risk factors for development of tgct - family history, cryptorchidism , testicular feminization , klinefelter syndrome, previous tgct, gonadal dysgenesis


HPO:

31
testicular germ cell tumor:
Inheritance somatic mutation sporadic


Classifications:

Orphanet: 55  
Rare urogenital diseases


Summaries for Testicular Germ Cell Tumor

OMIM : 53 Testicular germ cell tumors (TGCTs) affect 1 in 500 men and are the most common cancer in males aged 15 to 40 in western European populations. The incidence of TGCT rose dramatically during the 20th century. Known risk factors for TGCT include a history of undescended testis (UDT), testicular dysgenesis, infertility, previously diagnosed TGCT, and a family history of the disease. Brothers of men with TGCT have an 8- to 10-fold risk of developing TGCT, whereas the relative risk to fathers and sons is 4-fold. This familial relative risk is much higher than that for most other types of cancer (summary by Rapley et al., 2000). (273300)

MalaCards based summary : Testicular Germ Cell Tumor, also known as spermatocytic seminoma, is related to testicular germ cell cancer and teratoma, and has symptoms including abnormality of metabolism/homeostasis, cryptorchidism and gonadal dysgenesis. An important gene associated with Testicular Germ Cell Tumor is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Carboplatin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and bone marrow, and related phenotypes are Decreased viability and Decreased viability

UniProtKB/Swiss-Prot : 71 Testicular germ cell tumor: A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma.

Related Diseases for Testicular Germ Cell Tumor

Diseases in the Testicular Germ Cell Tumor family:

Testicular Germ Cell Tumor 1

Diseases related to Testicular Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell cancer 31.9 AR DMRT1 ESR2 KITLG SPRY4
2 teratoma 30.8 AFP DMRT1 KIT TP53
3 seminoma 30.8 AFP ESR2 KIT
4 testicular cancer 30.5 AFP AR STK11
5 malignant germ cell tumor 30.2 AFP AR ESR2
6 adenocarcinoma 30.0 AKT1 FGFR3 KIT TP53
7 lung cancer 28.6 AKT1 BAK1 BAX ESR2 FGFR3 KIT
8 testicular germ cell tumor 1 12.5
9 nonseminomatous germ cell tumor 12.5
10 testicular yolk sac tumor 12.5
11 extragonadal nonseminomatous germ cell tumor 12.4
12 testicular spermatocytic seminoma 12.4
13 vaginal yolk sac tumor 12.4
14 yolk sac tumor of central nervous system 12.4
15 pediatric testicular germ cell tumor 12.4
16 pineal region yolk sac tumor 12.2
17 glandular pattern ovarian yolk sac tumor 12.2
18 macrocystic pattern testicular yolk sac tumor 12.2
19 solid pattern testicular yolk sac tumor 12.2
20 glandular-alveolar pattern testicular yolk sac tumor 12.2
21 myxomatous pattern testicular yolk sac tumor 12.2
22 papillary pattern testicular yolk sac tumor 12.2
23 enteric pattern testicular yolk sac tumor 12.2
24 reticular pattern testicular yolk sac tumor 12.2
25 testicular germ cell tumor non-seminomatous 12.2
26 hepatoid pattern ovarian yolk sac tumor 12.2
27 polyvesicular vitelline pattern ovarian yolk sac tumor 12.2
28 endodermal sinus pattern testicular yolk sac tumor 12.2
29 polyvesicular vitelline pattern testicular yolk sac tumor 12.2
30 hepatoid pattern testicular yolk sac tumor 12.2
31 endodermal sinus tumor 12.1
32 pediatric cns embryonal cell carcinoma 12.1
33 testicular seminoma 11.5
34 spermatocytoma 11.4
35 childhood endodermal sinus tumor 11.3
36 central nervous system endodermal sinus tumor 11.3
37 childhood ovarian endodermal sinus tumor 11.3
38 pigmented villonodular synovitis 11.2
39 adult endodermal sinus tumor 11.2
40 ovarian endodermal sinus tumor 11.2
41 mediastinal endodermal sinus tumors 11.2
42 germ cells tumors 11.1
43 mixed germ cell tumor 10.6 AFP KIT
44 non-invasive bladder papillary urothelial neoplasm 10.5 FGFR3 TP53
45 seminal vesicle tumor 10.4 AFP GPC3 STK10
46 hereditary breast ovarian cancer syndrome 10.4 PTEN STK11 TP53
47 embryonal sarcoma 10.4 GPC3 KIT TP53
48 giant cell glioblastoma 10.4 FGFR3 PTEN TP53
49 hepatic angiomyolipoma 10.4 AFP KIT
50 peutz-jeghers syndrome 10.4 PTEN STK11 TP53

Graphical network of the top 20 diseases related to Testicular Germ Cell Tumor:



Diseases related to Testicular Germ Cell Tumor

Symptoms & Phenotypes for Testicular Germ Cell Tumor

Symptoms via clinical synopsis from OMIM:

53
Genitourinary Internal Genitalia Male:
painless testicular mass

Laboratory Abnormalities:
isochromosome 12p (i(12p))
elevated hcg (choriocarcinoma)
elevated afp (endodermal sinus tumor)
elevated hcg or afp or both (embryonal carcinoma)
azoospermia/oligospermia (present at diagnosis)

Neoplasia:
male germ cell tumors (gct), 2 subtypes -
seminoma
nonseminoma (embryonal carcinoma, teratoma, choriocarcinoma, endodermal sinus tumor)


Clinical features from OMIM:

273300

Human phenotypes related to Testicular Germ Cell Tumor:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 31 HP:0001939
2 cryptorchidism 31 HP:0000028
3 gonadal dysgenesis 31 HP:0000133
4 teratoma 31 HP:0009792

GenomeRNAi Phenotypes related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

25 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.09 KIT STK10 UCK2 AKT1 FGFR3
2 Decreased viability GR00221-A-2 10.09 FGFR3 STK10 UCK2 AKT1
3 Decreased viability GR00221-A-3 10.09 FGFR3 STK10 AKT1
4 Decreased viability GR00221-A-4 10.09 AKT1
5 Decreased viability GR00301-A 10.09 KIT
6 Decreased viability GR00342-S-1 10.09 STK10
7 Decreased viability GR00342-S-2 10.09 STK10
8 Decreased viability GR00342-S-3 10.09 STK10
9 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 PTEN STK11 AKT1 TP53 BAX BCL10
10 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 PTEN STK11 AKT1 TP53 BAK1 BAX
11 Increased cell viability after pRB stimulation GR00230-A-1 9.26 KIT STK10 STK11 AKT1

MGI Mouse Phenotypes related to Testicular Germ Cell Tumor:

43 (show all 25)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.46 KITLG KIT PTEN AKT1 AR TP53
2 endocrine/exocrine gland MP:0005379 10.44 PTEN KITLG BAK1 AR AFP AKT1
3 hematopoietic system MP:0005397 10.44 PTEN KITLG BAK1 AR AKT1 TP53
4 immune system MP:0005387 10.42 PTEN KITLG BAK1 AR AKT1 TP53
5 behavior/neurological MP:0005386 10.4 KIT AR AKT1 AFP PTEN STK11
6 growth/size/body region MP:0005378 10.4 KITLG KIT AR AKT1 PTEN STK11
7 homeostasis/metabolism MP:0005376 10.4 KITLG KIT PTEN AKT1 AFP AR
8 mortality/aging MP:0010768 10.4 PTEN KITLG BAK1 AR AFP AKT1
9 digestive/alimentary MP:0005381 10.3 KITLG KIT PTEN AR TP53 STK11
10 nervous system MP:0003631 10.28 KIT PTEN KITLG AKT1 AR SPRY4
11 limbs/digits/tail MP:0005371 10.26 PTEN KITLG BAK1 AR SPRY4 TP53
12 embryo MP:0005380 10.25 KITLG KIT AR AKT1 PTEN STK11
13 integument MP:0010771 10.24 KITLG KIT PTEN AKT1 AR TP53
14 neoplasm MP:0002006 10.23 PTEN KITLG BAK1 AR AFP AKT1
15 craniofacial MP:0005382 10.21 KITLG KIT AR STK11 SPRY4 TP53
16 liver/biliary system MP:0005370 10.21 KIT PTEN KITLG AKT1 AFP AR
17 muscle MP:0005369 10.13 KIT PTEN AKT1 AR STK11 TP53
18 reproductive system MP:0005389 10.13 PTEN KITLG BAK1 AR AFP AKT1
19 hearing/vestibular/ear MP:0005377 10.12 KITLG KIT BAX ESR2 BAK1 TP53
20 normal MP:0002873 10.1 KIT PTEN AKT1 AR STK11 TP53
21 renal/urinary system MP:0005367 10.02 KIT PTEN BAK1 AR TP53 STK11
22 pigmentation MP:0001186 9.85 KITLG KIT AR PTEN TP53 GPC3
23 respiratory system MP:0005388 9.85 KIT PTEN AKT1 SPRY4 TP53 STK11
24 skeleton MP:0005390 9.73 KIT PTEN KITLG AKT1 BAK1 AR
25 vision/eye MP:0005391 9.28 KITLG KIT PTEN STK11 SPRY4 BAX

Drugs & Therapeutics for Testicular Germ Cell Tumor

Drugs for Testicular Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 239)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
2
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
3
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
4
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
5
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
6
Vinblastine Approved Phase 3 865-21-4 241903 13342
7
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
8
Bleomycin Approved, Investigational Phase 3,Phase 2 11056-06-7 5360373
9
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
10
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 43805 6857599 5310940 9887054
11
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
12
Lenograstim Approved, Investigational Phase 2, Phase 3, Phase 1 135968-09-1
13
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
14
Ofloxacin Approved Phase 3 82419-36-1 4583
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
16
Captopril Approved Phase 3 62571-86-2 44093
17
Palivizumab Approved, Investigational Phase 3 188039-54-5
18
Ribavirin Approved Phase 3 36791-04-5 37542
19
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
20
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
21
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
22
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
23
Caspofungin Approved Phase 3,Phase 2 162808-62-0, 179463-17-3 2826718 468682
24
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
25
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
26
Moxifloxacin Approved, Investigational Phase 3 151096-09-2, 354812-41-2 152946
27
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
28
Cyproheptadine Approved Phase 3 129-03-3 2913
29
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
30
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
31
Mycophenolic acid Approved Phase 3 24280-93-1 446541
32 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
33 Alkylating Agents Phase 3,Phase 2,Phase 1
34 Antimitotic Agents Phase 3,Phase 2,Phase 1
35 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
36 Antirheumatic Agents Phase 3,Phase 2,Phase 1
37 Etoposide phosphate Phase 3,Phase 2,Phase 1
38 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
39 Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
40 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
41 Antiemetics Phase 3,Phase 2
42 Autonomic Agents Phase 3,Phase 2
43 Gastrointestinal Agents Phase 3,Phase 2
44 Neurotransmitter Agents Phase 3,Phase 2
45 Peripheral Nervous System Agents Phase 3,Phase 2
46
Serotonin Phase 3,Phase 2 50-67-9 5202
47 Serotonin Agents Phase 3,Phase 2
48 Serotonin Antagonists Phase 3,Phase 2
49 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
50 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 157)

# Name Status NCT ID Phase Drugs
1 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
2 Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors Unknown status NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
3 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
4 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
5 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
6 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
7 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
8 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
9 Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles Completed NCT00324298 Phase 3 cisplatin;etoposide
10 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
11 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
12 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
13 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
14 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
15 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
16 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
17 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
18 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
19 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
20 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
21 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
22 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
23 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
24 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
25 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
26 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
27 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
28 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
29 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
30 Combination Chemotherapy in Treating Patients With Germ Cell Tumors That Have Not Responded to Previous Cisplatin Completed NCT00002559 Phase 1, Phase 2 cisplatin;ifosfamide;paclitaxel
31 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
32 Arsenic Trioxide in Treating Men With Germ Cell Cancer Completed NCT00036842 Phase 2 arsenic trioxide
33 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
34 Paclitaxel Plus Gemcitabine in Treating Patients With Refractory Metastatic Germ Cell Tumors Completed NCT00003518 Phase 2 gemcitabine hydrochloride;paclitaxel
35 Temozolomide in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to Cisplatin Completed NCT00006043 Phase 2 temozolomide
36 Combination Chemotherapy Followed by Bone Marrow or Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00002508 Phase 1, Phase 2 carboplatin;etoposide
37 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors Completed NCT00002558 Phase 1, Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
38 Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer Completed NCT00002903 Phase 2 docetaxel
39 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
40 Carboplatin, Etoposide, Cyclophosphamide, and Autologous Bone Marrow Transplantation in Patients With Relapsed or Refractory Cancer Completed NCT00002943 Phase 2 carboplatin;cyclophosphamide;etoposide
41 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
42 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
43 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
44 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
45 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
46 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
47 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
48 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
49 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
50 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide

Search NIH Clinical Center for Testicular Germ Cell Tumor

Genetic Tests for Testicular Germ Cell Tumor

Genetic tests related to Testicular Germ Cell Tumor:

# Genetic test Affiliating Genes
1 Germ Cell Tumor, Nonseminomatous 28

Anatomical Context for Testicular Germ Cell Tumor

MalaCards organs/tissues related to Testicular Germ Cell Tumor:

38
Testis, Bone, Bone Marrow, Lymph Node, Brain, Small Intestine, Kidney

Publications for Testicular Germ Cell Tumor

Articles related to Testicular Germ Cell Tumor:

(show top 50) (show all 450)
# Title Authors Year
1
Risk stratification for febrile neutropenia in patients with testicular germ cell tumors. ( 29349917 )
2018
2
Increased risk of testis failure in testicular germ cell tumor survivors undergoing radiotherapy. ( 29423028 )
2018
3
Long-Term Cognitive Functioning in Testicular Germ-Cell Tumor Survivors. ( 29352051 )
2018
4
Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor. ( 28604728 )
2017
5
Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy. ( 28266817 )
2017
6
Low hypoxia inducible factor-1I+ (HIF-1I+) expression in testicular germ cell tumors - a major reason for enhanced chemosensitivity? ( 28947870 )
2017
7
Update on the Pathophysiology and Risk Factors for the Development of Malignant Testicular Germ Cell Tumors in Complete Androgen Insensitivity Syndrome. ( 28719895 )
2017
8
Future of testicular germ cell tumor incidence in the United States: Forecast through 2026. ( 28241106 )
2017
9
Bilateral methachronous testicular germ cell tumor and testicular microlithiasis in a child: Genetic analysis and insights. A case report. ( 29040905 )
2017
10
Association Between RASSF1A Promoter Methylation and Testicular Germ Cell Tumor: A Meta-analysis and a Cohort Study. ( 28871003 )
2017
11
Cutaneous Presentation of a Testicular Germ Cell Tumor With Seminomatous Differentiation. ( 28452794 )
2017
12
Gastrointestinal Involvement of Testicular Germ Cell Tumor: A Case Report and Literature Review. ( 29130004 )
2017
13
miRa89223a893p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors. ( 28000896 )
2017
14
Editorial Comment: Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy. ( 28783265 )
2017
15
Reporting and Staging of Testicular Germ Cell Tumors: The International Society of Urological Pathology (ISUP) Testicular Cancer Consultation Conference Recommendations. ( 28368923 )
2017
16
MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients. ( 28881587 )
2017
17
Mosaic chromosome Y loss and testicular germ cell tumor risk. ( 28275244 )
2017
18
Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. ( 28604732 )
2017
19
A CASE OF ADVANCED NON-SEMINOMATOUS TESTICULAR GERM CELL TUMOR ACCOMPANIED PANIC DISORDER. ( 28132992 )
2016
20
Identifying functional cancer-specific miRNA-mRNA interactions in testicular germ cell tumor. ( 27235586 )
2016
21
Wilms tumor gene 1 (WT1), TP53, RAS/BRAF and KIT aberrations in testicular germ cell tumors. ( 27085458 )
2016
22
Impact of Bep or Carboplatin Chemotherapy on Testicular Function and Sperm Nucleus of Subjects with Testicular Germ Cell Tumor. ( 27242529 )
2016
23
Familial testicular germ cell tumor with bilateral disease. ( 27072274 )
2016
24
Testicular germ cell tumor: Short and long-term side effects of treatment among survivors. ( 27588190 )
2016
25
A rare cause in etiology of left atrial mass: metastatic testicular germ cell tumor. ( 27212979 )
2016
26
Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway. ( 27158395 )
2016
27
Novel association of familial testicular germ cell tumor and autosomal dominant polycystic kidney disease with PKD1 mutation. ( 27577987 )
2016
28
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor. ( 26917601 )
2016
29
Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review. ( 27957372 )
2016
30
Does the Serum Metallothionein Level Reflect the Stage of Testicular Germ Cell Tumor? ( 27255355 )
2016
31
MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients. ( 27517619 )
2016
32
Hotspot TERT promoter mutations are rare events in testicular germ cell tumors. ( 26526580 )
2016
33
Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy. ( 26956871 )
2016
34
Consumption of alcoholic beverages in adolescence and adulthood and risk of testicular germ cell tumor. ( 27474852 )
2016
35
Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients. ( 27698832 )
2016
36
The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors. ( 27599467 )
2016
37
Re: Ultrasound Demonstration of Testicular Microlithiasis in Pediatric Patients: Is There an Association with Testicular Germ Cell Tumors? ( 27321534 )
2016
38
MAD2I^, a novel MAD2 isoform, reduces mitotic arrest and is associated with resistance in testicular germ cell tumors. ( 27315568 )
2016
39
Right Cardiac Chambers Involvement by a Malignant Testicular Germ Cell Tumor: An Imaging-pathologic Correlation. ( 27017904 )
2016
40
More Cases of Benign Testicular Teratomas are Detected in Adults than in Children. A Clinicopathological Study of 543 Testicular Germ Cell Tumor Cases. ( 27796764 )
2016
41
Testicular germ cell tumor genomics. ( 27584029 )
2016
42
[Polymorphisms of KITLG, SPRY4, and BAK1 genes in patients with testicular germ cell tumors and individuals with infertility associated with AZFc deletion of the Y chromosome]. ( 28064312 )
2016
43
A novel prognostic factor TRIM44 promotes cell proliferation and migration, and inhibits apoptosis in testicular germ cell tumor. ( 27754579 )
2016
44
Brain Metastases as Presenting Feature in 'Burned Out' Testicular Germ Cell Tumor. ( 27182465 )
2016
45
Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor. ( 27863478 )
2016
46
Sperm DNA Fragmentation Index and Hyaluronan Binding Ability in Men from Infertile Couples and Men with Testicular Germ Cell Tumor. ( 27999814 )
2016
47
MicroRNA miR-371a-3p - A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid. ( 26989896 )
2016
48
Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors. ( 26654129 )
2016
49
Long-term Relative Survival after Diagnosis of Testicular Germ Cell Tumor. ( 26908435 )
2016
50
Nontesticular cancers in relatives of testicular germ cell tumor (TGCT) patients from multiple-case TGCT families. ( 25882629 )
2015

Variations for Testicular Germ Cell Tumor

UniProtKB/Swiss-Prot genetic disease variations for Testicular Germ Cell Tumor:

71
# Symbol AA change Variation ID SNP ID
1 FGFR3 p.Lys650Glu VAR_004160 rs78311289
2 STK10 p.Lys277Glu VAR_023827 rs757545210
3 STK11 p.Gly163Asp VAR_033140 rs137853078

ClinVar genetic disease variations for Testicular Germ Cell Tumor:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HRAS NM_005343.3(HRAS): c.181C> A (p.Gln61Lys) single nucleotide variant Pathogenic/Likely pathogenic rs28933406 GRCh37 Chromosome 11, 533875: 533875
2 KIT NM_000222.2(KIT): c.2446G> C (p.Asp816His) single nucleotide variant Pathogenic/Likely pathogenic rs121913506 GRCh37 Chromosome 4, 55599320: 55599320
3 BRAF NM_004333.4(BRAF): c.1799T> A (p.Val600Glu) single nucleotide variant Pathogenic/Likely pathogenic rs113488022 GRCh37 Chromosome 7, 140453136: 140453136
4 FGFR3 NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu) single nucleotide variant Pathogenic/Likely pathogenic rs78311289 GRCh37 Chromosome 4, 1807889: 1807889
5 BCL10 NM_003921.4(BCL10): c.488C> T (p.Thr163Met) single nucleotide variant Pathogenic rs370432633 GRCh37 Chromosome 1, 85733524: 85733524
6 BCL10 NM_003921.4(BCL10): c.499_500insT (p.Ser167Phefs) insertion Pathogenic rs387906350 GRCh37 Chromosome 1, 85733513: 85733513
7 BCL10 NM_003921.4(BCL10): c.172C> G (p.Arg58Gly) single nucleotide variant Pathogenic rs121918314 GRCh37 Chromosome 1, 85736475: 85736475
8 BCL10 NM_003921.4(BCL10): c.172C> T (p.Arg58Ter) single nucleotide variant Pathogenic rs121918314 GRCh37 Chromosome 1, 85736475: 85736475
9 STK11 NM_000455.4(STK11): c.488G> A (p.Gly163Asp) single nucleotide variant Pathogenic rs137853078 GRCh37 Chromosome 19, 1220395: 1220395

Copy number variations for Testicular Germ Cell Tumor from CNVD:

7 (show all 12)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 19332 1 149600000 247249719 Gain Testicular germ cell tumor
2 42821 10 40300000 82000000 Loss Testicular germ cell tumor
3 61421 12 1 132349534 Gain Testicular germ cell tumor
4 89303 15 17000000 76100000 Loss Testicular germ cell tumor
5 121721 18 46400000 76117153 Loss Testicular germ cell tumor
6 146937 2 56300000 230700000 Loss Testicular germ cell tumor
7 180589 4 107900000 191273063 Loss Testicular germ cell tumor
8 206877 6 149100000 170899992 Loss Testicular germ cell tumor
9 226157 7 55086724 55275030 Amplification EGFR Testicular germ cell tumor
10 245111 9 101600000 129300000 Loss Testicular germ cell tumor
11 261703 X 24900000 29400000 Gain Testicular germ cell tumor
12 262543 X 37500000 146900000 Gain Testicular germ cell tumor

Expression for Testicular Germ Cell Tumor

Search GEO for disease gene expression data for Testicular Germ Cell Tumor.

Pathways for Testicular Germ Cell Tumor

Pathways related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 AKT1 BAK1 BAX ESR2 FGFR3 KIT
2
Show member pathways
13.39 AKT1 AR BAX FGFR3 KIT KITLG
3
Show member pathways
13.09 AKT1 FGFR3 KIT KITLG PTEN TP53
4
Show member pathways
13.03 AKT1 FGFR3 KIT KITLG PTEN TP53
5
Show member pathways
12.99 AKT1 AR BAK1 BAX FGFR3 KIT
6
Show member pathways
12.73 AKT1 BAK1 BAX FGFR3 KIT KITLG
7 12.72 AKT1 FGFR3 KIT KITLG TP53
8
Show member pathways
12.69 AKT1 BAK1 BAX ESR2 KIT PTEN
9
Show member pathways
12.62 AKT1 BCL10 FGFR3 KIT KITLG PTEN
10
Show member pathways
12.53 AKT1 BAK1 BAX PTEN TP53
11
Show member pathways
12.46 AKT1 FGFR3 GPC3 PTEN STK11 TP53
12
Show member pathways
12.41 AKT1 BAX FGFR3 TP53
13
Show member pathways
12.35 AKT1 BAX PTEN TP53
14
Show member pathways
12.34 BAK1 BAX KIT KITLG TP53
15
Show member pathways
12.22 AKT1 BAX PTEN TP53
16
Show member pathways
12.18 AKT1 BAX FGFR3 PTEN TP53
17
Show member pathways
12.14 AKT1 KIT KITLG PTEN
18
Show member pathways
12.11 AKT1 BAK1 BAX TP53
19
Show member pathways
12.1 AKT1 BAX STK11 TP53
20 12.04 AKT1 AR BAK1 BAX ESR2 FGFR3
21 12.01 AFP BAK1 BAX PTEN TP53
22
Show member pathways
11.99 AKT1 BAK1 BAX TP53
23 11.96 AKT1 BAX PTEN TP53
24 11.86 AKT1 BAK1 BAX PTEN TP53
25 11.82 AKT1 AR PTEN
26 11.78 AKT1 PTEN TP53
27
Show member pathways
11.77 AKT1 BAX KIT
28 11.76 AFP AKT1 BAX TP53
29 11.75 AKT1 BAK1 BAX PTEN STK11 TP53
30 11.74 BAK1 BAX TP53
31 11.73 AKT1 BAK1 BAX PTEN TP53
32 11.7 AKT1 BAK1 BAX TP53
33 11.69 AKT1 AR BAK1 BAX PTEN STK11
34 11.65 AKT1 PTEN TP53
35 11.56 AKT1 PTEN TP53
36 11.53 BAK1 BAX TP53
37 11.53 AKT1 FGFR3 KIT PTEN TP53
38 11.42 AKT1 BAX PTEN TP53
39 11.35 BAK1 BAX TP53
40 11.11 AKT1 BAK1 BAX

GO Terms for Testicular Germ Cell Tumor

Cellular components related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.56 AKT1 BAK1 BAX ESR2 HSD17B4 PTEN
2 pore complex GO:0046930 8.62 BAK1 BAX
3 cytoplasm GO:0005737 10 AFP AKT1 AR BAX BCL10 DMRT1

Biological processes related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.97 AKT1 BAK1 BAX BCL10 FGFR3 PTEN
2 positive regulation of apoptotic process GO:0043065 9.93 AKT1 BAK1 BAX BCL10 PTEN TP53
3 aging GO:0007568 9.92 AKT1 BAK1 PTEN TP53
4 regulation of apoptotic process GO:0042981 9.88 AKT1 BAK1 BAX BCL10 STK10 TP53
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.87 KITLG STK11 TP53
6 cellular response to mechanical stimulus GO:0071260 9.87 AKT1 BAK1 BCL10
7 negative regulation of cell proliferation GO:0008285 9.87 AR BAK1 BAX GPC3 PTEN STK11
8 protein oligomerization GO:0051259 9.85 AR BAX BCL10
9 protein autophosphorylation GO:0046777 9.83 AKT1 FGFR3 KIT STK10 STK11
10 negative regulation of epithelial cell proliferation GO:0050680 9.82 AR GPC3 PTEN
11 positive regulation of DNA binding transcription factor activity GO:0051091 9.81 AKT1 ESR2 KIT PTEN
12 cellular response to UV GO:0034644 9.79 BAK1 BAX TP53
13 ovarian follicle development GO:0001541 9.76 BAX KIT KITLG
14 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.73 BAX STK11 TP53
15 response to gamma radiation GO:0010332 9.72 BAK1 BAX TP53
16 positive regulation of calcium ion transport into cytosol GO:0010524 9.71 BAK1 BAX
17 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.71 BAK1 BAX KITLG
18 regulation of mitochondrial membrane permeability GO:0046902 9.7 BAK1 TP53
19 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.7 BAK1 BAX
20 Sertoli cell development GO:0060009 9.7 DMRT1 HSD17B4
21 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.7 BAK1 BAX TP53
22 regulation of protein heterodimerization activity GO:0043497 9.69 BAK1 BAX
23 anoikis GO:0043276 9.69 AKT1 STK11
24 negative regulation of cell size GO:0045792 9.68 AKT1 PTEN
25 vagina development GO:0060068 9.68 BAK1 BAX
26 myeloid cell homeostasis GO:0002262 9.67 BAK1 BAX
27 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 9.67 BAK1 BAX
28 germ cell migration GO:0008354 9.67 DMRT1 KIT
29 negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 9.66 BAK1 BAX
30 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.66 BAK1 BAX
31 activation of signaling protein activity involved in unfolded protein response GO:0006987 9.65 BAK1 BAX
32 positive regulation of IRE1-mediated unfolded protein response GO:1903896 9.65 BAK1 BAX
33 prostate gland growth GO:0060736 9.65 AR PTEN
34 sex differentiation GO:0007548 9.65 AR BAX DMRT1
35 regulation of protein homodimerization activity GO:0043496 9.63 BAK1 BAX
36 response to fungus GO:0009620 9.63 BAK1 BCL10
37 positive regulation of endoplasmic reticulum unfolded protein response GO:1900103 9.61 BAK1 BAX
38 thymocyte apoptotic process GO:0070242 9.61 BAK1 BAX
39 apoptotic process involved in blood vessel morphogenesis GO:1902262 9.6 BAK1 BAX
40 cellular response to decreased oxygen levels GO:0036294 9.59 AKT1 PTEN
41 post-embryonic camera-type eye morphogenesis GO:0048597 9.57 BAK1 BAX
42 B cell negative selection GO:0002352 9.49 BAK1 BAX
43 B cell apoptotic process GO:0001783 9.43 BAK1 BAX BCL10
44 male gonad development GO:0008584 9.35 AR BAX DMRT1 KIT KITLG
45 ectopic germ cell programmed cell death GO:0035234 9.33 BAX KIT KITLG
46 cell proliferation GO:0008283 9.17 AKT1 AR BAK1 BAX KITLG PTEN
47 phosphorylation GO:0016310 10.11 AKT1 FGFR3 KIT STK10 STK11 UCK2
48 spermatogenesis GO:0007283 10.07 AR BAX DMRT1 KIT STK11
49 positive regulation of cell proliferation GO:0008284 10.05 AKT1 AR FGFR3 KIT KITLG PTEN

Molecular functions related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.8 AKT1 FGFR3 KIT STK10 STK11
2 kinase activity GO:0016301 9.73 AKT1 FGFR3 KIT STK10 STK11 UCK2
3 protein homodimerization activity GO:0042803 9.7 AKT1 BAK1 BAX DMRT1 HSD17B4 KIT
4 chaperone binding GO:0051087 9.54 BAK1 BAX TP53
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.5 FGFR3 KIT KITLG
6 enzyme binding GO:0019899 9.43 AKT1 AR BCL10 ESR2 PTEN TP53
7 identical protein binding GO:0042802 9.32 AKT1 BAK1 BAX BCL10 DMRT1 ESR2

Sources for Testicular Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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