MCID: TST021
MIFTS: 59

Testicular Germ Cell Tumor malady

Genetic diseases (common), Reproductive diseases, Cancer diseases categories

Summaries for Testicular Germ Cell Tumor

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OMIM:47 Testicular germ cell tumors (TGCTs) affect 1 in 500 men and are the most common cancer in males aged 15 to 40 in... (273300) more...

MalaCards based summary: Testicular Germ Cell Tumor, also known as male germ cell tumor, is related to teratoma and testicular cancer, and has symptoms including cryptorchidism, gonadal dysgenesis and abnormality of metabolism/homeostasis. An important gene associated with Testicular Germ Cell Tumor is BCL10 (B-cell CLL/lymphoma 10), and among its related pathways are PI-3K cascade and Downstream Signaling Events Of B Cell Receptor (BCR). The compounds ponatinib and pazopanib have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and testis germ, and related mouse phenotypes are no phenotypic analysis and reproductive system.

Wikipedia:65 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

Aliases & Classifications for Testicular Germ Cell Tumor

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Testicular Germ Cell Tumor, Aliases & Descriptions:

Name: Testicular Germ Cell Tumor 47 62
Male Germ Cell Tumor 47 11
Spermatocytic Seminoma, Somatic 47
 
Male Germ Cell Tumor, Somatic 47
Testicular Tumor, Somatic 47
Germ Cell Tumors 47


Classifications:



External Ids:

OMIM47 273300

Related Diseases for Testicular Germ Cell Tumor

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Diseases related to Testicular Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma30.9DND1, UTF1, KIT
2testicular cancer30.6SPRY4, AZF1, STK11, DND1
3nonseminomatous germ cell tumor11.2
4mixed germ cell tumor11.2
5central nervous system germ cell tumor10.8
6growing teratoma syndrome10.7
7seminoma10.7
8pediatric testicular germ cell tumor10.7
9germinoma10.6
10malignant pineal area germ cell neoplasm10.6
11endodermal sinus tumor10.6
12prostatitis10.6
13polyembryoma10.6
14testicular microlithiasis10.6
15rhabdomyosarcoma10.6
16teratocarcinoma10.5
17testicular non seminomatous germ cell tumor10.5
18choriocarcinoma10.5
19thymic hyperplasia10.5
20klinefelter's syndrome10.5
21histiocytosis10.5
22dysgerminoma10.5
23extragonadal nonseminomatous germ cell tumor10.5
24malignant cardiac germ cell tumor10.5
25malignant gastric germ cell tumor10.5
26cryptorchidism10.4
27angiosarcoma10.4
28mature teratoma10.4
29extragonadal germ cell tumor10.4
30episodic ataxia10.4
31malignant histiocytosis10.4
32central nervous system adult germ cell tumor10.4
33craniopharyngioma10.4
34ovarian primitive germ cell tumor10.4
35pediatric ovarian germ cell tumor10.4
36precocious puberty10.4
37renal cell carcinoma10.3
38gonadoblastoma10.3
39cerebritis10.3
40cervicitis10.3
41childhood testicular mixed germ cell tumor10.3
42gonadal dysgenesis10.3
43extracranial germ cell tumor, childhood10.3
44mixed germ cell tumor of the central nervous system10.3
45malignant germ cell tumor of the cervix uteri10.3
46pseudo-meigs syndrome10.3
47chondrosarcoma10.3
48retinoblastoma10.3
49lung cancer10.3
50acute monocytic leukemia10.3

Graphical network of the top 20 diseases related to Testicular Germ Cell Tumor:



Diseases related to testicular germ cell tumor

Symptoms for Testicular Germ Cell Tumor

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Symptoms by clinical synopsis from OMIM:

273300

Clinical features from OMIM:

273300

HPO human phenotypes related to Testicular Germ Cell Tumor:

id Description Frequency HPO Source Accession
1 cryptorchidism HP:0000028
2 gonadal dysgenesis HP:0000133
3 abnormality of metabolism/homeostasis HP:0001939
4 sporadic HP:0003745
5 teratoma HP:0009792

Drugs & Therapeutics for Testicular Germ Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Testicular Germ Cell Tumor

Search NIH Clinical Center for Testicular Germ Cell Tumor

Genetic Tests for Testicular Germ Cell Tumor

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Anatomical Context for Testicular Germ Cell Tumor

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MalaCards organs/tissues related to Testicular Germ Cell Tumor:

33
Testis, Ovary, Testis germ, Lymph node, Brain, Testes, Lung, Bone, Retina, Heart, Kidney, Pancreas, Monocytes, Endothelial, Pineal, Pituitary

Animal Models for Testicular Germ Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Testicular Germ Cell Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.8STK11, DPPA3, KIT, FGFR3, SPRY4
2MP:00053899.4FGFR3, UTF1, STK11, DPPA3, DND1, KIT
3MP:00053809.3DPPA3, ESX1, UTF1, STK11, BCL10, PHLDA3

Publications for Testicular Germ Cell Tumor

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Articles related to Testicular Germ Cell Tumor:

(show top 50)    (show all 381)
idTitleAuthorsYear
1
Validation of Surveillance, Epidemiology, and End Results TNM staging for testicular germ cell tumor. (24856980)
2014
2
Metastasectomy as optimal treatment for late relapsing solitary brain metastasis from testicular germ cell tumor: a case report. (25444462)
2014
3
miRNA-1297 induces cell proliferation by targeting phosphatase and tensin homolog in testicular germ cell tumor cells. (25124605)
2014
4
Phytoestrogens regulate the proliferation and expression of stem cell factors in cell lines of malignant testicular germ cell tumors. (23969837)
2013
5
Multifocality in testicular germ cell tumor (TGCT): what is the significance of this finding? (24318367)
2013
6
Relationship between primary and metastatic testicular germ cell tumors: a clinicopathologic analysis of 100 cases. (23856516)
2013
7
Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors. (24059746)
2013
8
Commentary on "effective testicular germ cell tumor therapy on renal function." Cost NG, Adibi M, Lubahn JD et al, Department of Urology, University of Texas Southwestern Medical School, Dallas, TX: Urology 2012;80:641. (23465476)
2013
9
Clinical significance of amyloid precursor protein in patients with testicular germ cell tumor. (23662100)
2013
10
Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: an overview. (23359388)
2013
11
Cryptorchidism and testicular germ cell tumors: comprehensive meta-analysis reveals that association between these conditions diminished over time and is modified by clinical characteristics. (23423470)
2012
12
Androgen-producing testicular germ cell tumors. (21606422)
2011
13
New prognostic markers and potential therapeutic targets in human testicular germ cell tumors. (22050751)
2011
14
Heterogenous effect of androgen receptor CAG tract length on testicular germ cell tumor risk: shorter repeats associated with seminoma but not other histologic types. (21642359)
2011
15
Retroperitoneal and metachronous testicular germ cell tumors with different histology and teratoma growing syndrome--a case report. (22053583)
2011
16
Primitive neuroectodermal tumors in patients with testicular germ cell tumors usually resemble pediatric-type central nervous system embryonal neoplasms and lack chromosome 22 rearrangements. (20348883)
2010
17
Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma. (19836053)
2010
18
The role of microenvironment in testicular germ cell tumors. (20855948)
2010
19
The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancers. (20395447)
2010
20
Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors. (20092957)
2010
21
Recent developments in testicular germ cell tumor research. (19306344)
2009
22
Reoperative retroperitoneal lymph-node dissection for testicular germ cell tumor. (19636565)
2009
23
Embryogenesis and metastatic testicular germ cell tumors of adolescents. (19437359)
2009
24
Genetic variants in the 8q24 locus and risk of testicular germ cell tumors. (18373104)
2008
25
Expression of splicing variants of the inhibitor of apoptosis livin in testicular germ cell tumors. (18515985)
2008
26
Testicular germ cell tumors in mice: new ways to study a genetically complex trait. (18370062)
2008
27
Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (18413775)
2008
28
Persistent organochlorine pesticides and risk of testicular germ cell tumors. (18445826)
2008
29
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. (17695719)
2007
30
Intra-abdominal desmoid tumor following retroperitoneal lymph node dissection for testicular germ cell tumor. (16448440)
2006
31
Microsatellite instability and loss of heterozygosity have distinct prognostic value for testicular germ cell tumor recurrence. (15492498)
2004
32
Resistance to platinum-containing chemotherapy in testicular germ cell tumors is associated with downregulation of the protein kinase SRPK1. (15256051)
2004
33
Estrogen receptor-beta expression in human testicular germ cell tumors. (14555521)
2003
34
Multipoint methylation analysis indicates a distinctive epigenetic phenotype among testicular germ cell tumors and testicular malignant lymphomas. (12874790)
2003
35
Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors. (11358847)
2001
36
Testis sparing surgery for the treatment of a sequential bilateral testicular germ cell tumor. (11851774)
2001
37
Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumors. (11764380)
2001
38
Characterization of multiple 12p rearrangements in testicular germ cell tumor cell line 833K and its subclone 64CP by chromosome microdissection. (9772905)
1998
39
Advanced testicular germ cell tumor in a hemophilic patient with human immunodeficiency virus infection. (9793032)
1998
40
Importance of a new tumor marker TRA-1-60 in the follow-up of patients with clinical stage I nonseminomatous testicular germ cell tumors. (9181232)
1997
41
Sexual functioning after multimodality treatment for disseminated nonseminomatous testicular germ cell tumor. (9302133)
1997
42
Serum and tissue levels of manganese superoxide dismutase in testicular germ cell tumors. (8791060)
1996
43
Immunohistochemical assessment of tumor proliferation and volume of embryonal carcinoma identify patients with clinical stage A nonseminomatous testicular germ cell tumor at low risk for occult metastasis. (7828136)
1995
44
Testicular germ cell tumor with gastric metastasis. (8396398)
1993
45
Testicular germ cell tumor seven years after a retroperitoneal germ cell tumor. (1655464)
1991
46
Interphase cytogenetics in paraffin embedded sections from human testicular germ cell tumor xenografts and in corresponding cultured cells. (2755080)
1989
47
Thymic hyperplasia following chemotherapy of a testicular germ cell tumor. Immunohistological evidence for a simple rebound phenomenon. (2536289)
1989
48
Chromosome 12q heterozygosity is retained in i(12p)-positive testicular germ cell tumor cells. (2569358)
1989
49
Malignant testicular germ cell tumor in father and son: a case report. (2545021)
1989
50
Congenital anomalies in children with testicular germ cell tumor. (6449607)
1980

Variations for Testicular Germ Cell Tumor

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UniProtKB/Swiss-Prot genetic disease variations for Testicular Germ Cell Tumor:

64
id Symbol AA change Variation ID SNP ID
1FGFR3p.Lys650GluVAR_004160
2STK10p.Lys277GluVAR_023827
3STK11p.Gly163AspVAR_033140

Clinvar genetic disease variations for Testicular Germ Cell Tumor:

7
id Gene Variation Type Significance SNP ID Assembly Location
1KITNM_000222.2(KIT): c.2446G> C (p.Asp816His)single nucleotide variantPathogenicrs121913506GRCh37Chr 4, 55599320: 55599320
2FGFR3NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu)single nucleotide variantPathogenicrs78311289GRCh37Chr 4, 1807889: 1807889
3BCL10BCL10, THR161METsingle nucleotide variantPathogenic
4STK11NM_000455.4(STK11): c.488G> A (p.Gly163Asp)single nucleotide variantPathogenicrs137853078GRCh37Chr 19, 1220395: 1220395

Expression for genes affiliated with Testicular Germ Cell Tumor

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Search GEO for disease gene expression data for Testicular Germ Cell Tumor.

Pathways for genes affiliated with Testicular Germ Cell Tumor

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Compounds for genes affiliated with Testicular Germ Cell Tumor

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Compounds related to Testicular Germ Cell Tumor according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ponatinib51 1311.3FGFR3, KIT
2pazopanib51 1311.0FGFR3, KIT

GO Terms for genes affiliated with Testicular Germ Cell Tumor

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Cellular components related to Testicular Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:000989810.3FGFR3, KIT

Biological processes related to Testicular Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat1 proteinGO:004251110.4KIT, FGFR3
2positive regulation of phosphatidylinositol 3-kinase activityGO:004355210.4KIT, FGFR3
3signal transduction by phosphorylationGO:002301410.3KIT, STK10
4positive regulation of protein ubiquitinationGO:003139810.3BCL10, FGFR3
5positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.3KIT, FGFR3
6protein autophosphorylationGO:004677710.2STK10, STK11, KIT, FGFR3
7Fc-epsilon receptor signaling pathwayGO:003809510.0BCL10, KIT, FGFR3
8somatic stem cell maintenanceGO:003501910.0FGFR3, KIT

Products for genes affiliated with Testicular Germ Cell Tumor

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Sources for Testicular Germ Cell Tumor

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet