MCID: TST021
MIFTS: 67

Testicular Germ Cell Tumor

Categories: Genetic diseases, Rare diseases, Cancer diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Testicular Germ Cell Tumor

MalaCards integrated aliases for Testicular Germ Cell Tumor:

Name: Testicular Germ Cell Tumor 54 50 71 69
Spermatocytic Seminoma 56 71 69
Embryonal Cell Carcinoma 71 69
Endodermal Sinus Tumor 56 71
Male Germ Cell Tumor 71 69
Testicular Teratoma 56 52
Yolk Sac Tumor 56 69
Seminoma 71 69
Malignant Testicular Non-Seminomatous Germ Cell Tumor 69
Testicular Non-Dysgerminomatous Germ Cell Tumor 56
Non-Dysgerminomatous Germ Cell Tumor of Testis 56
Testicular Non Seminomatous Germ Cell Tumor 56
Testicular Non-Seminomatous Germ Cell Tumor 69
Non-Seminomatous Germ Cell Tumor of Testis 56
Testicular Seminomatous Germ Cell Tumor 56
Seminomatous Germ Cell Tumor of Testis 56
Nonseminomatous Germ Cell Tumors 71
Germ Cell Tumor, Nonseminomatous 29
Spermatocytic Seminoma, Somatic 54
Nonseminomatous Germ Cell Tumor 69
Male Germ Cell Tumor, Somatic 54
Germ Cell Tumors, Somatic 54
Testicular Tumor, Somatic 54
Germ Cell Tumor of Testis 50
Teratoma of the Testis 56
Testicular Seminoma 56
Teratoma Testicular 71
Seminoma of Testis 56
Teratoma of Testis 69
Tgct 71
Mgct 71

Characteristics:

Orphanet epidemiological data:

56
testicular seminomatous germ cell tumor
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-5/10000 (Europe); Age of onset: Adult; Age of death: adult,elderly,young Adult;
non-seminomatous germ cell tumor of testis
Prevalence: 1-9/100000 (Europe),1-5/10000 (Europe);
testicular teratoma
Prevalence: <1/1000000 (Europe);
spermatocytic seminoma
Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult; Age of death: normal life expectancy;

OMIM:

54
Inheritance:
somatic mutation

Miscellaneous:
two subtypes - seminoma and nonseminoma
occasionally germ cell tumor arise from extra gonadal site (e.g., mediastinum, retroperitoneum, pineal gland)
most common cancer in men aged 15-40 years
highest incidence in men of european descent
risk factors for development of tgct - family history, cryptorchidism , testicular feminization , klinefelter syndrome, previous tgct, gonadal dysgenesis


HPO:

32
testicular germ cell tumor:
Inheritance somatic mutation sporadic


Classifications:

Orphanet: 56  
Rare urogenital diseases


External Ids:

OMIM 54 273300
UMLS via Orphanet 70 C0036631 C0014145 C0238451 more
ICD10 via Orphanet 34 C62.9 C56 C62.1

Summaries for Testicular Germ Cell Tumor

OMIM : 54
Testicular germ cell tumors (TGCTs) affect 1 in 500 men and are the most common cancer in males aged 15 to 40 in western European populations. The incidence of TGCT rose dramatically during the 20th century. Known risk factors for TGCT include a history of undescended testis (UDT), testicular dysgenesis, infertility, previously diagnosed TGCT, and a family history of the disease. Brothers of men with TGCT have an 8- to 10-fold risk of developing TGCT, whereas the relative risk to fathers and sons is 4-fold. This familial relative risk is much higher than that for most other types of cancer (summary by Rapley et al., 2000). (273300)

MalaCards based summary : Testicular Germ Cell Tumor, also known as spermatocytic seminoma, is related to splenic infarction and lung cancer, and has symptoms including cryptorchidism, gonadal dysgenesis and abnormality of metabolism/homeostasis. An important gene associated with Testicular Germ Cell Tumor is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways are ERK Signaling and Class I MHC mediated antigen processing and presentation. The drugs Carboplatin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and bone marrow, and related phenotypes are Decreased viability and cellular

UniProtKB/Swiss-Prot : 71 Testicular germ cell tumor: A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma.

Related Diseases for Testicular Germ Cell Tumor

Diseases related to Testicular Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
id Related Disease Score Top Affiliating Genes
1 splenic infarction 30.0 AR ESR2 PTEN TP53
2 lung cancer 27.7 AKT1 BAK1 BAX CDKN1A ESR2 FGFR3
3 endodermal sinus tumor 12.6
4 childhood endodermal sinus tumor 12.4
5 nonseminomatous germ cell tumor 12.3
6 extragonadal nonseminomatous germ cell tumor 12.3
7 adult endodermal sinus tumor 12.3
8 ovarian endodermal sinus tumor 12.3
9 testicular spermatocytic seminoma 12.2
10 pediatric testicular germ cell tumor 12.2
11 mediastinal endodermal sinus tumors 12.2
12 testicular germ cell tumor non-seminomatous 12.1
13 childhood ovarian endodermal sinus tumor 12.0
14 central nervous system endodermal sinus tumor 12.0
15 pediatric cns embryonal cell carcinoma 11.9
16 testicular seminoma 11.4
17 yolk sac tumor of central nervous system 11.3
18 spermatocytoma 11.2
19 pigmented villonodular synovitis 11.2
20 germ cells tumors 11.1
21 testicular germ cell cancer 11.1
22 testicular yolk sac tumor 11.0
23 testis seminoma 11.0
24 giant adenofibroma of the breast 10.8 AFP KIT
25 night blindness 10.7 AFP FGFR3 STK11
26 hypersensitivity reaction type iii disease 10.7 AFP KIT TP53
27 cerebellar vermis medulloblastoma 10.7 AFP GPC3 STK10
28 enamel hypoplasia cataract hydrocephaly 10.7 GPC3 KIT TP53
29 spiradenoma 10.7 AR KIT STK11
30 cellular myxoid liposarcoma 10.7 PTEN STK11 TP53
31 juvenile astrocytoma 10.6 FGFR3 PTEN TP53
32 pulmonary embolism and infarction 10.6 AR TP53
33 epidermolysis bullosa simplex-mcr 10.6 FGFR3 KIT KITLG STK11
34 bleeding disorder, platelet-type, 13 10.6 PTEN STK11 TP53
35 brachyolmia 10.6 KIT PTEN TP53
36 extra-adrenal pheochromocytoma 10.6 GPC3 PTEN TP53
37 colon signet ring adenocarcinoma 10.6 AFP BCL10 TP53
38 dubin-johnson syndrome 10.5 KIT PTEN STK11 TP53
39 central nervous system disease 10.5 AFP DMRT1 KIT TP53
40 microcystic adenoma 10.5 KITLG PTEN TP53
41 gangliosidosis gm1 10.5 AFP KIT
42 lung clear cell-sugar-tumor 10.5 CDKN1A KIT TP53
43 acute cholinergic dysautonomia 10.5 CDKN1A TP53
44 pylorus cancer 10.5 BAX BCL10 TP53
45 endometriosis of uterus 10.5 ESR2 PTEN TP53
46 heavy chain disease 10.5 AKT1 KIT TP53
47 childhood ovarian embryonal carcinoma 10.5 ESR2 PTEN TP53
48 gestational choriocarcinoma 10.5 AKT1 KIT TP53
49 childhood kidney cell carcinoma 10.4 AFP ESR2 KIT
50 breast myoepithelial neoplasm 10.4 PTEN TP53

Graphical network of the top 20 diseases related to Testicular Germ Cell Tumor:



Diseases related to Testicular Germ Cell Tumor

Symptoms & Phenotypes for Testicular Germ Cell Tumor

Symptoms via clinical synopsis from OMIM:

54

Genitourinary- Internal Genitalia Male:
painless testicular mass

Laboratory- Abnormalities:
isochromosome 12p (i(12p))
elevated hcg (choriocarcinoma)
elevated afp (endodermal sinus tumor)
elevated hcg or afp or both (embryonal carcinoma)
azoospermia/oligospermia (present at diagnosis)

Neoplasia:
male germ cell tumors (gct), 2 subtypes -
seminoma
nonseminoma (embryonal carcinoma, teratoma, choriocarcinoma, endodermal sinus tumor)


Clinical features from OMIM:

273300

Human phenotypes related to Testicular Germ Cell Tumor:

32
id Description HPO Frequency HPO Source Accession
1 cryptorchidism 32 HP:0000028
2 gonadal dysgenesis 32 HP:0000133
3 abnormality of metabolism/homeostasis 32 HP:0001939
4 teratoma 32 HP:0009792

GenomeRNAi Phenotypes related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.09 AKT1 FGFR3 KIT STK10 UCK2
2 Decreased viability GR00221-A-2 10.09 AKT1 FGFR3 STK10 UCK2
3 Decreased viability GR00221-A-3 10.09 AKT1 FGFR3 STK10
4 Decreased viability GR00221-A-4 10.09 AKT1
5 Decreased viability GR00301-A 10.09 KIT
6 Decreased viability GR00342-S-1 10.09 STK10
7 Decreased viability GR00342-S-2 10.09 STK10
8 Decreased viability GR00342-S-3 10.09 STK10
9 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.78 BAX BCL10 CDKN1A PTEN STK11 TP53
10 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.78 BCL10 CDKN1A PTEN STK11 TP53 AKT1
11 Increased cell viability after pRB stimulation GR00230-A-1 9.26 STK11 AKT1 KIT STK10

MGI Mouse Phenotypes related to Testicular Germ Cell Tumor:

44 (show all 26)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.46 AKT1 AR BAK1 BAX BCL10 CDKN1A
2 endocrine/exocrine gland MP:0005379 10.44 AFP AKT1 AR BAK1 BAX BCL10
3 hematopoietic system MP:0005397 10.44 AKT1 AR BAK1 BAX BCL10 CDKN1A
4 immune system MP:0005387 10.42 GPC3 KIT KITLG PTEN STK10 STK11
5 behavior/neurological MP:0005386 10.41 AFP AKT1 AR BAK1 BAX CDKN1A
6 growth/size/body region MP:0005378 10.4 KITLG PTEN SPRY4 STK11 TP53 AKT1
7 homeostasis/metabolism MP:0005376 10.4 AFP AKT1 AR BAK1 BAX CDKN1A
8 mortality/aging MP:0010768 10.4 AFP AKT1 AR BAK1 BAX BCL10
9 cardiovascular system MP:0005385 10.32 AKT1 AR CDKN1A ESR2 GPC3 KIT
10 digestive/alimentary MP:0005381 10.3 AR CDKN1A ESR2 FGFR3 GPC3 KIT
11 embryo MP:0005380 10.3 AKT1 AR BCL10 CDKN1A GPC3 KIT
12 limbs/digits/tail MP:0005371 10.3 ESR2 FGFR3 GPC3 KIT KITLG PTEN
13 integument MP:0010771 10.28 AKT1 AR CDKN1A ESR2 FGFR3 GPC3
14 nervous system MP:0003631 10.28 AKT1 AR BAK1 BAX BCL10 CDKN1A
15 neoplasm MP:0002006 10.27 BAX CDKN1A ESR2 FGFR3 KIT KITLG
16 craniofacial MP:0005382 10.26 TP53 AR CDKN1A FGFR3 GPC3 KIT
17 liver/biliary system MP:0005370 10.21 AFP AKT1 AR CDKN1A ESR2 KIT
18 hearing/vestibular/ear MP:0005377 10.18 BAK1 BAX CDKN1A ESR2 FGFR3 KIT
19 muscle MP:0005369 10.13 AKT1 AR BAX CDKN1A ESR2 KIT
20 reproductive system MP:0005389 10.13 AFP AKT1 AR BAK1 BAX CDKN1A
21 normal MP:0002873 10.06 BAK1 ESR2 FGFR3 KIT PTEN STK11
22 renal/urinary system MP:0005367 10.06 CDKN1A ESR2 FGFR3 GPC3 KIT PTEN
23 respiratory system MP:0005388 9.9 STK11 TP53 FGFR3 GPC3 KIT PTEN
24 pigmentation MP:0001186 9.85 AR GPC3 KIT KITLG PTEN TP53
25 skeleton MP:0005390 9.77 AKT1 AR BAK1 BAX CDKN1A ESR2
26 vision/eye MP:0005391 9.28 PTEN SPRY4 STK11 TP53 BAX CDKN1A

Drugs & Therapeutics for Testicular Germ Cell Tumor

Drugs for Testicular Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 256)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
2
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
3
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
4
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
5
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
6
Vinblastine Approved Phase 3 865-21-4 13342 241903
7
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
8
Bleomycin Approved Phase 3,Phase 2 11056-06-7 5360373
9
Mechlorethamine Approved Phase 3,Phase 1,Phase 2 51-75-2 4033
10
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 5310940 9887054 43805 6857599
11
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
12
Lenograstim Approved Phase 2, Phase 3, Phase 1 135968-09-1
13
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
14
Mesna Approved Phase 3,Phase 1,Phase 2 3375-50-6 598
15
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
16
Ofloxacin Approved Phase 3 82419-36-1 4583
17
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
18
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
19
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
20
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
21
Fluconazole Approved Phase 3 86386-73-4 3365
22
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
23
Palivizumab Approved, Investigational Phase 3 188039-54-5
24
Ribavirin Approved Phase 3 36791-04-5 37542
25
Captopril Approved Phase 3 62571-86-2 44093
26
Diphenhydramine Approved Phase 3 58-73-1, 147-24-0 3100
27
Promethazine Approved Phase 3 60-87-7 4927
28
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
29
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
30
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
31
Norgestimate Approved Phase 3 35189-28-7 6540478
32
Cyproheptadine Approved Phase 3 129-03-3 2913
33
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
34
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
35
Mycophenolic acid Approved Phase 3 24280-93-1 446541
36 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
37 Alkylating Agents Phase 3,Phase 2,Phase 1
38 Antimitotic Agents Phase 3,Phase 2,Phase 1
39 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
40 Antirheumatic Agents Phase 3,Phase 2,Phase 1
41 Etoposide phosphate Phase 3,Phase 2,Phase 1
42 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
43 Isophosphamide mustard Phase 3,Phase 2,Phase 1
44 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
45 Antiemetics Phase 3,Phase 2
46 Autonomic Agents Phase 3,Phase 2
47 Gastrointestinal Agents Phase 3,Phase 2
48 Neurotransmitter Agents Phase 3,Phase 2
49 Peripheral Nervous System Agents Phase 3,Phase 2
50
Serotonin Phase 3,Phase 2 50-67-9 5202

Interventional clinical trials:

(show top 50) (show all 183)

id Name Status NCT ID Phase Drugs
1 Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors Unknown status NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
2 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
3 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
4 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
5 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
6 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
7 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
8 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
9 Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles Completed NCT00324298 Phase 3 cisplatin;etoposide
10 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
11 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
12 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
13 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
14 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
15 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
16 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
17 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
18 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
19 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
20 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
21 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
22 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
23 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
24 Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours Recruiting NCT02582697 Phase 3 Bleomycin (active name: Bleomycin Sulfate);Etoposide;Cisplatin;Pegylated G-CSF (Pegfilgrastim);Filgrastim
25 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
26 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Active, not recruiting NCT00053352 Phase 3 cisplatin;etoposide
27 Trial of 1 Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Testis Tumours Active, not recruiting NCT01726374 Phase 3 BEP(500)
28 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
29 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
30 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
31 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
32 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
33 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
34 Sorafenib Monotherapy in Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy Unknown status NCT00772694 Phase 2 sorafenib
35 Trial of Gemcitabine, Cisplatin, and Ifosfamide in Patients With Relapsed Non-Seminomatous Germ-Cell Tumors Unknown status NCT00127049 Phase 2 gemcitabine, ifosfamide, cisplatin, G-CSF
36 Pazopanib in Advanced and Cisplatin-resistant Germ Cell Tumors Unknown status NCT01743482 Phase 2 Pazopanib
37 Combination Chemotherapy in Treating Patients With Germ Cell Tumors That Have Not Responded to Previous Cisplatin Completed NCT00002559 Phase 1, Phase 2 cisplatin;ifosfamide;paclitaxel
38 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
39 Arsenic Trioxide in Treating Men With Germ Cell Cancer Completed NCT00036842 Phase 2 arsenic trioxide
40 Paclitaxel Plus Gemcitabine in Treating Patients With Refractory Metastatic Germ Cell Tumors Completed NCT00003518 Phase 2 gemcitabine hydrochloride;paclitaxel
41 Temozolomide in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to Cisplatin Completed NCT00006043 Phase 2 temozolomide
42 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
43 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors Completed NCT00002558 Phase 1, Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
44 Combination Chemotherapy Followed by Bone Marrow or Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00002508 Phase 1, Phase 2 carboplatin;etoposide
45 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
46 Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer Completed NCT00002903 Phase 2 docetaxel
47 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
48 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
49 Everolimus in Refractory Testicular Germ Cell Cancer Completed NCT01466231 Phase 2 Everolimus
50 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel

Search NIH Clinical Center for Testicular Germ Cell Tumor

Genetic Tests for Testicular Germ Cell Tumor

Genetic tests related to Testicular Germ Cell Tumor:

id Genetic test Affiliating Genes
1 Germ Cell Tumor, Nonseminomatous 29

Anatomical Context for Testicular Germ Cell Tumor

MalaCards organs/tissues related to Testicular Germ Cell Tumor:

39
Testis, Bone, Bone Marrow, Lymph Node, Brain, Small Intestine, Kidney

Publications for Testicular Germ Cell Tumor

Articles related to Testicular Germ Cell Tumor:

(show top 50) (show all 444)
id Title Authors Year
1
Cutaneous Presentation of a Testicular Germ Cell Tumor With Seminomatous Differentiation. ( 28452794 )
2017
2
Mosaic chromosome Y loss and testicular germ cell tumor risk. ( 28275244 )
2017
3
MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients. ( 28881587 )
2017
4
Future of testicular germ cell tumor incidence in the United States: Forecast through 2026. ( 28241106 )
2017
5
Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy. ( 28266817 )
2017
6
Reporting and Staging of Testicular Germ Cell Tumors: The International Society of Urological Pathology (ISUP) Testicular Cancer Consultation Conference Recommendations. ( 28368923 )
2017
7
Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor. ( 28604728 )
2017
8
Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. ( 28604732 )
2017
9
miRa89223a893p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors. ( 28000896 )
2017
10
Update on the Pathophysiology and Risk Factors for the Development of Malignant Testicular Germ Cell Tumors in Complete Androgen Insensitivity Syndrome. ( 28719895 )
2017
11
Association Between RASSF1A Promoter Methylation and Testicular Germ Cell Tumor: A Meta-analysis and a Cohort Study. ( 28871003 )
2017
12
Editorial Comment: Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy. ( 28783265 )
2017
13
Low hypoxia inducible factor-1I+ (HIF-1I+) expression in testicular germ cell tumors - a major reason for enhanced chemosensitivity? ( 28947870 )
2017
14
Re: Ultrasound Demonstration of Testicular Microlithiasis in Pediatric Patients: Is There an Association with Testicular Germ Cell Tumors? ( 27321534 )
2016
15
MicroRNA miR-371a-3p - A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid. ( 26989896 )
2016
16
Impact of Bep or Carboplatin Chemotherapy on Testicular Function and Sperm Nucleus of Subjects with Testicular Germ Cell Tumor. ( 27242529 )
2016
17
Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor. ( 27863478 )
2016
18
Consumption of alcoholic beverages in adolescence and adulthood and risk of testicular germ cell tumor. ( 27474852 )
2016
19
Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review. ( 27957372 )
2016
20
Novel association of familial testicular germ cell tumor and autosomal dominant polycystic kidney disease with PKD1 mutation. ( 27577987 )
2016
21
Sperm DNA Fragmentation Index and Hyaluronan Binding Ability in Men from Infertile Couples and Men with Testicular Germ Cell Tumor. ( 27999814 )
2016
22
Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients. ( 27698832 )
2016
23
Right Cardiac Chambers Involvement by a Malignant Testicular Germ Cell Tumor: An Imaging-pathologic Correlation. ( 27017904 )
2016
24
The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors. ( 27599467 )
2016
25
Testicular germ cell tumor: Short and long-term side effects of treatment among survivors. ( 27588190 )
2016
26
Hotspot TERT promoter mutations are rare events in testicular germ cell tumors. ( 26526580 )
2016
27
MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients. ( 27517619 )
2016
28
Does the Serum Metallothionein Level Reflect the Stage of Testicular Germ Cell Tumor? ( 27255355 )
2016
29
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor. ( 26917601 )
2016
30
Long-term Relative Survival after Diagnosis of Testicular Germ Cell Tumor. ( 26908435 )
2016
31
Familial testicular germ cell tumor with bilateral disease. ( 27072274 )
2016
32
Testicular germ cell tumor genomics. ( 27584029 )
2016
33
A CASE OF ADVANCED NON-SEMINOMATOUS TESTICULAR GERM CELL TUMOR ACCOMPANIED PANIC DISORDER. ( 28132992 )
2016
34
Identifying functional cancer-specific miRNA-mRNA interactions in testicular germ cell tumor. ( 27235586 )
2016
35
A novel prognostic factor TRIM44 promotes cell proliferation and migration, and inhibits apoptosis in testicular germ cell tumor. ( 27754579 )
2016
36
[Polymorphisms of KITLG, SPRY4, and BAK1 genes in patients with testicular germ cell tumors and individuals with infertility associated with AZFc deletion of the Y chromosome]. ( 28064312 )
2016
37
Wilms tumor gene 1 (WT1), TP53, RAS/BRAF and KIT aberrations in testicular germ cell tumors. ( 27085458 )
2016
38
MAD2I^, a novel MAD2 isoform, reduces mitotic arrest and is associated with resistance in testicular germ cell tumors. ( 27315568 )
2016
39
More Cases of Benign Testicular Teratomas are Detected in Adults than in Children. A Clinicopathological Study of 543 Testicular Germ Cell Tumor Cases. ( 27796764 )
2016
40
Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway. ( 27158395 )
2016
41
A rare cause in etiology of left atrial mass: metastatic testicular germ cell tumor. ( 27212979 )
2016
42
Brain Metastases as Presenting Feature in 'Burned Out' Testicular Germ Cell Tumor. ( 27182465 )
2016
43
Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors. ( 26654129 )
2016
44
Vasculogenesis and angiogenesis in nonseminomatous testicular germ cell tumors. ( 25772688 )
2015
45
Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor. ( 25877299 )
2015
46
Re: Craniocaudal Retroperitoneal Node Length as a Risk Factor for Relapse from Clinical Stage I Testicular Germ Cell Tumor. ( 26582668 )
2015
47
The role of spermatogenesis-associated protein 6 in testicular germ cell tumors. ( 26464655 )
2015
48
Oncological Outcomes in Japanese Men Undergoing Orchiectomy for Stage I Testicular Germ Cell Tumor. ( 26889123 )
2015
49
Nontesticular cancers in relatives of testicular germ cell tumor (TGCT) patients from multiple-case TGCT families. ( 25882629 )
2015
50
Benign neck metastasis of a testicular germ cell tumor. ( 25594657 )
2015

Variations for Testicular Germ Cell Tumor

UniProtKB/Swiss-Prot genetic disease variations for Testicular Germ Cell Tumor:

71
id Symbol AA change Variation ID SNP ID
1 FGFR3 p.Lys650Glu VAR_004160 rs78311289
2 STK10 p.Lys277Glu VAR_023827 rs757545210
3 STK11 p.Gly163Asp VAR_033140 rs137853078

ClinVar genetic disease variations for Testicular Germ Cell Tumor:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 BCL10 NM_003921.4(BCL10): c.499_500insT (p.Ser167Phefs) insertion Pathogenic rs387906350 GRCh37 Chromosome 1, 85733513: 85733513
2 BCL10 NM_003921.4(BCL10): c.172C> G (p.Arg58Gly) single nucleotide variant Pathogenic rs121918314 GRCh37 Chromosome 1, 85736475: 85736475
3 BCL10 NM_003921.4(BCL10): c.172C> T (p.Arg58Ter) single nucleotide variant Pathogenic rs121918314 GRCh37 Chromosome 1, 85736475: 85736475
4 STK11 NM_000455.4(STK11): c.488G> A (p.Gly163Asp) single nucleotide variant Pathogenic rs137853078 GRCh37 Chromosome 19, 1220395: 1220395
5 HRAS NM_005343.3(HRAS): c.181C> A (p.Gln61Lys) single nucleotide variant Pathogenic/Likely pathogenic rs28933406 GRCh37 Chromosome 11, 533875: 533875
6 KIT NM_000222.2(KIT): c.2446G> C (p.Asp816His) single nucleotide variant Pathogenic/Likely pathogenic rs121913506 GRCh37 Chromosome 4, 55599320: 55599320
7 BRAF NM_004333.4(BRAF): c.1799T> A (p.Val600Glu) single nucleotide variant Pathogenic/Likely pathogenic rs113488022 GRCh37 Chromosome 7, 140453136: 140453136
8 FGFR3 NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu) single nucleotide variant Pathogenic/Likely pathogenic rs78311289 GRCh37 Chromosome 4, 1807889: 1807889
9 BCL10 NM_003921.4(BCL10): c.488C> T (p.Thr163Met) single nucleotide variant Pathogenic rs370432633 GRCh37 Chromosome 1, 85733524: 85733524

Copy number variations for Testicular Germ Cell Tumor from CNVD:

7 (show all 12)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 19332 1 149600000 247249719 Gain Testicular germ cell tumor
2 42821 10 40300000 82000000 Loss Testicular germ cell tumor
3 61421 12 1 132349534 Gain Testicular germ cell tumor
4 89303 15 17000000 76100000 Loss Testicular germ cell tumor
5 121721 18 46400000 76117153 Loss Testicular germ cell tumor
6 146937 2 56300000 230700000 Loss Testicular germ cell tumor
7 180589 4 107900000 191273063 Loss Testicular germ cell tumor
8 206877 6 149100000 170899992 Loss Testicular germ cell tumor
9 226157 7 55086724 55275030 Amplification EGFR Testicular germ cell tumor
10 245111 9 101600000 129300000 Loss Testicular germ cell tumor
11 261703 X 24900000 29400000 Gain Testicular germ cell tumor
12 262543 X 37500000 146900000 Gain Testicular germ cell tumor

Expression for Testicular Germ Cell Tumor

Search GEO for disease gene expression data for Testicular Germ Cell Tumor.

Pathways for Testicular Germ Cell Tumor

Pathways related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 AKT1 BAK1 BAX CDKN1A ESR2 FGFR3
2
Show member pathways
13.47 AKT1 BCL10 CDKN1A FGFR3 KIT KITLG
3
Show member pathways
13.38 AKT1 AR BAX CDKN1A FGFR3 KIT
4
Show member pathways
13.07 AKT1 FGFR3 KIT KITLG PTEN TP53
5
Show member pathways
12.98 AKT1 BAX CDKN1A PTEN STK11 TP53
6
Show member pathways
12.82 AKT1 BAK1 BAX CDKN1A TP53
7
Show member pathways
12.72 AKT1 BCL10 CDKN1A FGFR3 KIT KITLG
8 12.52 BAK1 CDKN1A FGFR3 PTEN TP53
9
Show member pathways
12.5 AKT1 FGFR3 GPC3 PTEN STK11 TP53
10
Show member pathways
12.49 AKT1 AR BAK1 BAX CDKN1A ESR2
11 12.49 AKT1 BAK1 BAX CDKN1A FGFR3 KIT
12 12.43 AKT1 BAX CDKN1A TP53
13
Show member pathways
12.4 AKT1 BAX CDKN1A PTEN TP53
14
Show member pathways
12.37 BAX CDKN1A PTEN TP53
15
Show member pathways
12.37 BAK1 BAX CDKN1A KIT KITLG TP53
16 12.3 AKT1 CDKN1A GPC3 TP53
17 12.29 BAK1 BAX CDKN1A TP53
18
Show member pathways
12.26 AKT1 BAX CDKN1A FGFR3 PTEN TP53
19
Show member pathways
12.25 AKT1 BAX CDKN1A PTEN TP53
20 12.24 BAK1 BAX CDKN1A TP53
21 12.21 AKT1 AR BAX CDKN1A FGFR3 KIT
22 12.19 AKT1 BAX CDKN1A TP53
23
Show member pathways
12.17 AKT1 KIT KITLG PTEN
24
Show member pathways
12.14 AKT1 BAX STK11 TP53
25
Show member pathways
12.12 AKT1 AR CDKN1A PTEN
26
Show member pathways
12.09 AKT1 CDKN1A PTEN STK11
27 12.05 AFP BAK1 BAX CDKN1A PTEN TP53
28
Show member pathways
12.03 AKT1 BAK1 BAX TP53
29 12 AKT1 BAX PTEN TP53
30 11.97 AKT1 CDKN1A PTEN TP53
31 11.94 AKT1 BAK1 BAX CDKN1A PTEN TP53
32 11.89 AKT1 AR BAK1 BAX PTEN STK11
33 11.87 AKT1 AR CDKN1A PTEN
34 11.84 AFP AKT1 BAX CDKN1A TP53
35 11.82 AKT1 PTEN TP53
36 11.81 BAK1 BAX TP53
37
Show member pathways
11.8 AKT1 BAX KIT
38 11.77 CDKN1A KIT KITLG
39 11.77 AKT1 BAK1 BAX CDKN1A TP53
40 11.76 AKT1 AR CDKN1A
41 11.73 CDKN1A FGFR3 TP53
42 11.72 AKT1 BAK1 BAX CDKN1A PTEN TP53
43 11.71 AKT1 FGFR3 KIT PTEN TP53
44 11.69 AKT1 PTEN TP53
45 11.58 AKT1 PTEN TP53
46 11.56 AKT1 CDKN1A TP53
47 11.56 BAK1 BAX CDKN1A TP53
48 11.43 AKT1 BAX CDKN1A PTEN TP53
49 11.41 BAX CDKN1A TP53
50 11.38 BAK1 BAX TP53

GO Terms for Testicular Germ Cell Tumor

Cellular components related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 AFP AKT1 AR BAX BCL10 CDKN1A
2 pore complex GO:0046930 8.96 BAK1 BAX

Biological processes related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.95 AKT1 BAK1 BAX BCL10 PTEN TP53
2 regulation of cell cycle GO:0051726 9.92 BAK1 BAX CDKN1A PTEN
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.9 KITLG STK11 TP53
4 positive regulation of MAPK cascade GO:0043410 9.89 AR FGFR3 KIT
5 cellular response to mechanical stimulus GO:0071260 9.89 AKT1 BAK1 BCL10
6 negative regulation of cell growth GO:0030308 9.88 CDKN1A ESR2 STK11 TP53
7 protein oligomerization GO:0051259 9.87 AR BAX BCL10
8 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.86 AKT1 ESR2 KIT PTEN
9 negative regulation of epithelial cell proliferation GO:0050680 9.85 AR GPC3 PTEN
10 protein autophosphorylation GO:0046777 9.85 AKT1 FGFR3 KIT STK10 STK11
11 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.84 BAX CDKN1A TP53
12 cellular response to UV GO:0034644 9.83 BAK1 BAX TP53
13 ovarian follicle development GO:0001541 9.8 BAX KIT KITLG
14 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.8 AKT1 FGFR3 KIT KITLG
15 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.78 BAK1 BAX KITLG
16 response to gamma radiation GO:0010332 9.77 BAK1 BAX TP53
17 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.77 BAX STK11 TP53
18 intrinsic apoptotic signaling pathway GO:0097193 9.74 BAX CDKN1A TP53
19 regulation of apoptotic process GO:0042981 9.73 BAK1 BAX BCL10 TP53
20 response to arsenic-containing substance GO:0046685 9.72 CDKN1A PTEN
21 positive regulation of calcium ion transport into cytosol GO:0010524 9.72 BAK1 BAX
22 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.72 BAK1 BAX
23 replicative senescence GO:0090399 9.72 CDKN1A TP53
24 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.72 BAK1 BAX TP53
25 male gonad development GO:0008584 9.72 AR BAX DMRT1 KIT KITLG
26 regulation of mitochondrial membrane permeability GO:0046902 9.71 BAK1 TP53
27 anoikis GO:0043276 9.71 AKT1 STK11
28 negative regulation of cell size GO:0045792 9.71 AKT1 PTEN
29 vagina development GO:0060068 9.7 BAK1 BAX
30 myeloid cell homeostasis GO:0002262 9.7 BAK1 BAX
31 cell proliferation GO:0008283 9.7 AKT1 AR BAK1 BAX KITLG PTEN
32 germ cell migration GO:0008354 9.69 DMRT1 KIT
33 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 9.69 BAK1 BAX
34 negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 9.69 BAK1 BAX
35 sex differentiation GO:0007548 9.69 AR BAX DMRT1
36 regulation of protein heterodimerization activity GO:0043497 9.68 BAK1 BAX
37 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.68 BAK1 BAX
38 activation of signaling protein activity involved in unfolded protein response GO:0006987 9.68 BAK1 BAX
39 positive regulation of IRE1-mediated unfolded protein response GO:1903896 9.68 BAK1 BAX
40 cellular response to UV-B GO:0071493 9.67 CDKN1A STK11
41 regulation of protein homodimerization activity GO:0043496 9.66 BAK1 BAX
42 prostate gland growth GO:0060736 9.66 AR PTEN
43 response to fungus GO:0009620 9.65 BAK1 BCL10
44 positive regulation of endoplasmic reticulum unfolded protein response GO:1900103 9.65 BAK1 BAX
45 thymocyte apoptotic process GO:0070242 9.64 BAK1 BAX
46 apoptotic process involved in blood vessel morphogenesis GO:1902262 9.64 BAK1 BAX
47 signal transduction by p53 class mediator GO:0072331 9.63 CDKN1A TP53
48 cellular response to decreased oxygen levels GO:0036294 9.62 AKT1 PTEN
49 post-embryonic camera-type eye morphogenesis GO:0048597 9.58 BAK1 BAX
50 negative regulation of cell proliferation GO:0008285 9.56 AR BAK1 BAX CDKN1A GPC3 PTEN

Molecular functions related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.77 BAK1 BAX DMRT1 KIT STK10
2 identical protein binding GO:0042802 9.7 AKT1 BAK1 BAX BCL10 PTEN STK10
3 protein kinase binding GO:0019901 9.65 AKT1 BCL10 CDKN1A PTEN TP53
4 chaperone binding GO:0051087 9.61 BAK1 BAX TP53
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.5 FGFR3 KIT KITLG
6 kinase activity GO:0016301 9.5 AKT1 CDKN1A FGFR3 KIT STK10 STK11
7 enzyme binding GO:0019899 9.1 AKT1 AR BCL10 ESR2 PTEN TP53
8 protein binding GO:0005515 10.33 AFP AKT1 AR BAK1 BAX BCL10

Sources for Testicular Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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