TGCT
MCID: TST021
MIFTS: 69

Testicular Germ Cell Tumor (TGCT) malady

Categories: Genetic diseases, Rare diseases, Cancer diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Testicular Germ Cell Tumor

Aliases & Descriptions for Testicular Germ Cell Tumor:

Name: Testicular Germ Cell Tumor 54 50 66 69
Spermatocytic Seminoma 56 66 69
Male Germ Cell Tumor 54 66 69
Nonseminomatous Germ Cell Tumors 66 29
Embryonal Cell Carcinoma 66 69
Endodermal Sinus Tumor 56 66
Testicular Teratoma 56 52
Germ Cells Tumors 50 29
Germ Cell Tumors 54 13
Yolk Sac Tumor 56 69
Seminoma 66 69
Malignant Testicular Non-Seminomatous Germ Cell Tumor 69
Testicular Non-Dysgerminomatous Germ Cell Tumor 56
Non-Dysgerminomatous Germ Cell Tumor of Testis 56
Testicular Non Seminomatous Germ Cell Tumor 56
Testicular Non-Seminomatous Germ Cell Tumor 69
Non-Seminomatous Germ Cell Tumor of Testis 56
Testicular Seminomatous Germ Cell Tumor 56
Seminomatous Germ Cell Tumor of Testis 56
Spermatocytic Seminoma, Somatic 54
Nonseminomatous Germ Cell Tumor 69
Male Germ Cell Tumor, Somatic 54
Testicular Tumor, Somatic 54
Germ Cell Tumor of Testis 50
Teratoma of the Testis 56
Testicular Seminoma 56
Teratoma Testicular 66
Seminoma of Testis 56
Teratoma of Testis 69
Germ Cell Tumor 69
Tgct 66
Mgct 66

Characteristics:

Orphanet epidemiological data:

56
testicular seminomatous germ cell tumor
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-5/10000 (Europe); Age of onset: Adult; Age of death: adult,elderly,young Adult;
non-seminomatous germ cell tumor of testis
Prevalence: 1-9/100000 (Europe),1-5/10000 (Europe);
testicular teratoma
Prevalence: <1/1000000 (Europe);
spermatocytic seminoma
Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult; Age of death: normal life expectancy;

HPO:

32
testicular germ cell tumor:
Inheritance somatic mutation sporadic


Classifications:

Orphanet: 56  
Rare urogenital diseases


External Ids:

OMIM 54 273300
ICD10 via Orphanet 34 C62.9 C56 C62.1
UMLS via Orphanet 70 C0014145 C0334517

Summaries for Testicular Germ Cell Tumor

OMIM : 54 Testicular germ cell tumors (TGCTs) affect 1 in 500 men and are the most common cancer in males aged 15 to 40 in... (273300) more...

MalaCards based summary : Testicular Germ Cell Tumor, also known as spermatocytic seminoma, is related to kidney disease and mature teratoma, and has symptoms including abnormality of metabolism/homeostasis, cryptorchidism and gonadal dysgenesis. An important gene associated with Testicular Germ Cell Tumor is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Cisplatin and Dacarbazine have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and testis germ, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and cellular

UniProtKB/Swiss-Prot : 66 Testicular germ cell tumor: A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma.

Wikipedia : 71 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

Related Diseases for Testicular Germ Cell Tumor

Diseases related to Testicular Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
id Related Disease Score Top Affiliating Genes
1 kidney disease 30.0 AFP BAX TP53
2 mature teratoma 29.9 AR DMRT1 ESR2 KITLG SPRY4
3 splenic infarction 29.6 AR ESR2 GSTP1 PTEN TP53
4 endodermal sinus tumor 12.6
5 childhood endodermal sinus tumor 12.4
6 nonseminomatous germ cell tumor 12.4
7 ovarian endodermal sinus tumor 12.3
8 testicular spermatocytic seminoma 12.3
9 adult endodermal sinus tumor 12.3
10 pediatric testicular germ cell tumor 12.2
11 mediastinal endodermal sinus tumors 12.2
12 central nervous system germ cell tumor 12.2
13 central nervous system endodermal sinus tumor 12.1
14 testicular germ cell tumor non-seminomatous 12.1
15 childhood ovarian endodermal sinus tumor 12.0
16 pediatric cns embryonal cell carcinoma 12.0
17 spermatocytoma 11.3
18 yolk sac tumor of central nervous system 11.3
19 testicular germ cell cancer 11.2
20 pigmented villonodular synovitis 11.1
21 testicular yolk sac tumor 11.0
22 testis seminoma 11.0
23 apical myocardial infarction 10.3 DMRT1 FGFR3 KIT
24 impetigo 10.3 AFP FGFR3 STK11
25 medullomyoblastoma 10.3 AFP GPC3 STK10
26 arthus reaction 10.3 AFP KIT TP53
27 laryngeal neuroendocrine tumor 10.3 AR KIT STK11
28 epidermolysis bullosa simplex, recessive 1 10.3 FGFR3 KIT KITLG STK11
29 enchondromatosis dwarfism deafness 10.2 GPC3 KIT TP53
30 uterine corpus serous adenocarcinoma 10.2 AFP BCL10 GPC3
31 early myoclonic encephalopathy 10.2 FGFR3 PTEN TP53
32 retroperitoneal neuroblastoma 10.2 GPC3 PTEN TP53
33 herpes simplex encephalitic 6 10.2 PTEN STK11 TP53
34 basophilic carcinoma 10.2 AFP GPC3 TP53
35 seminoma 10.2
36 reactive arthritis 10.2 ESR2 KIT TP53
37 pyloric antrum cancer 10.2 BAX BCL10 TP53
38 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 3 10.2 KIT PTEN STK11 TP53
39 larynx liposarcoma 10.2 PTEN STK11 TP53
40 submucosal invasive colon adenocarcinoma 10.2 AFP BCL10 STK11 TP53
41 breast myoepithelial neoplasm 10.2 AFP AR DMRT1 STK11
42 malignant teratocarcinosarcoma 10.2 AFP AR ESR2
43 childhood teratocarcinoma of the testis 10.2 AKT1 PTEN STK11
44 embryonal carcinoma 10.1
45 alpha chain disease 10.1 AKT1 KIT TP53
46 teratoma 10.1
47 testicular microlithiasis 10.1
48 kidney benign neoplasm 10.1 AKT1 ESR2 TP53
49 endocervicitis 10.1 AKT1 BAX ESR2
50 pituitary stalk meningioma 10.1 ESR2 PTEN TP53

Graphical network of the top 20 diseases related to Testicular Germ Cell Tumor:



Diseases related to Testicular Germ Cell Tumor

Symptoms & Phenotypes for Testicular Germ Cell Tumor

Symptoms by clinical synopsis from OMIM:

273300

Clinical features from OMIM:

273300

Human phenotypes related to Testicular Germ Cell Tumor:

32
id Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 32 HP:0001939
2 cryptorchidism 32 HP:0000028
3 gonadal dysgenesis 32 HP:0000133
4 teratoma 32 HP:0009792

GenomeRNAi Phenotypes related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 BAX BCL10 PTEN STK11 TP53 AKT1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 BAK1 BAX BCL10 PTEN STK11 TP53
3 Increased cell viability after pRB stimulation GR00230-A-1 9.26 AKT1 KIT STK10 STK11

MGI Mouse Phenotypes related to Testicular Germ Cell Tumor:

44 (show all 25)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.43 AR BAK1 BAX BCL10 ESR2 FGFR3
2 hematopoietic system MP:0005397 10.41 TP53 FGFR3 GPC3 KIT KITLG PTEN
3 endocrine/exocrine gland MP:0005379 10.4 AFP AKT1 AR BAK1 BAX BCL10
4 immune system MP:0005387 10.39 AKT1 AR BAK1 BAX BCL10 ESR2
5 homeostasis/metabolism MP:0005376 10.37 AFP AKT1 AR BAK1 BAX ESR2
6 mortality/aging MP:0010768 10.37 AFP AKT1 AR BAK1 BAX BCL10
7 behavior/neurological MP:0005386 10.36 TP53 AFP AKT1 AR BAK1 BAX
8 growth/size/body region MP:0005378 10.36 AKT1 AR BAX ESR2 FGFR3 GPC3
9 digestive/alimentary MP:0005381 10.26 PTEN STK11 TP53 AR ESR2 FGFR3
10 limbs/digits/tail MP:0005371 10.26 SPRY4 TP53 AR BAK1 BAX ESR2
11 embryo MP:0005380 10.25 KIT KITLG PTEN STK11 TP53 AKT1
12 nervous system MP:0003631 10.25 AR BAK1 BAX BCL10 ESR2 FGFR3
13 integument MP:0010771 10.24 AKT1 AR ESR2 FGFR3 GPC3 KIT
14 neoplasm MP:0002006 10.23 FGFR3 KIT KITLG PTEN STK11 TP53
15 craniofacial MP:0005382 10.21 AR FGFR3 GPC3 KIT KITLG SPRY4
16 liver/biliary system MP:0005370 10.16 AFP AKT1 AR ESR2 KIT KITLG
17 hearing/vestibular/ear MP:0005377 10.12 BAK1 BAX ESR2 FGFR3 KIT KITLG
18 reproductive system MP:0005389 10.1 AFP AKT1 AR BAK1 BAX DMRT1
19 muscle MP:0005369 10.08 AKT1 AR BAX ESR2 KIT PTEN
20 normal MP:0002873 10.06 BAK1 ESR2 FGFR3 KIT PTEN STK11
21 renal/urinary system MP:0005367 10.02 AR BAK1 BAX ESR2 FGFR3 GPC3
22 pigmentation MP:0001186 9.85 AR GPC3 KIT KITLG PTEN TP53
23 respiratory system MP:0005388 9.85 AKT1 BAX ESR2 FGFR3 GPC3 KIT
24 skeleton MP:0005390 9.73 BAX ESR2 FGFR3 GPC3 KIT KITLG
25 vision/eye MP:0005391 9.23 BAX FGFR3 KIT KITLG PTEN SPRY4

Drugs & Therapeutics for Testicular Germ Cell Tumor

Drugs for Testicular Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 932)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
2
Dacarbazine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 4342-03-4 5351166
3
Vindesine Approved Phase 4,Phase 3,Phase 2 59917-39-4, 53643-48-4 40839
4
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 5754 657311
5
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
6
Ranibizumab Approved Phase 4,Phase 2,Phase 3,Phase 1 347396-82-1 459903
7
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 41575-94-4 10339178 498142 38904
8
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 159351-69-6 6442177
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
10
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
11
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53123-88-9 5284616 6436030 46835353
12
Temozolomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 85622-93-1 5394
13
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 99011-02-6 57469
14
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
15
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
16
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1 3778-73-2 3690
17
Mechlorethamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-75-2 4033
18
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
19
Lenograstim Approved Phase 4,Phase 2,Phase 3,Phase 1 135968-09-1
20
Mesna Approved Phase 4,Phase 3,Phase 1,Phase 2 3375-50-6 598
21
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
22
Thiotepa Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 52-24-4 5453
23
Somatostatin Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 38916-34-6, 51110-01-1 53481605
24
Aminolevulinic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 106-60-5 137
25
Sunitinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 341031-54-7, 557795-19-4 5329102
26
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 124-94-7 31307
27
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 1 302962-49-8 3062316
28
Sorafenib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 284461-73-0 216239 406563
29
Trametinib Approved Phase 4,Phase 3,Phase 2,Phase 1 871700-17-3 11707110
30
Aldesleukin Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 85898-30-2, 110942-02-4
31
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 1 84625-61-6 55283
32
lanreotide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 108736-35-2
33
Etanercept Approved, Investigational Phase 4,Phase 2 185243-69-0
34
Pancrelipase Approved Phase 4,Phase 3,Phase 2,Phase 1 53608-75-6
35
nivolumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 946414-94-4
36
Nicotine Approved Phase 4 54-11-5 942 89594
37
Bortezomib Approved, Investigational Phase 4,Phase 1,Phase 2 179324-69-7 387447 93860
38
Gefitinib Approved, Investigational Phase 4,Phase 1,Phase 2 184475-35-2 123631
39
Ramucirumab Approved, Investigational Phase 4,Phase 2,Phase 1 947687-13-0
40
Vorinostat Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 149647-78-9 5311
41
Valproic Acid Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 99-66-1 3121
42
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 1994-09-7, 94-09-7 2337
43
Diazoxide Approved Phase 4,Phase 3,Phase 2 364-98-7 3019
44
Nitroglycerin Approved, Investigational Phase 4,Phase 2 55-63-0 4510
45
Doxazosin Approved Phase 4 74191-85-8 3157
46
Phenoxybenzamine Approved Phase 4 59-96-1 4768
47
Ceritinib Approved Phase 4,Phase 2,Phase 1,Early Phase 1 1032900-25-6
48
Crizotinib Approved Phase 4,Phase 3,Phase 2,Phase 1 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
49
Olaparib Approved Phase 4,Phase 2,Phase 1 763113-22-0 23725625
50
Palbociclib Approved Phase 4,Phase 2,Phase 1 571190-30-2 11431660 5005498 5330286

Interventional clinical trials:

(show top 50) (show all 4750)
id Name Status NCT ID Phase
1 Disease-Specific Questionnaire in Assessing Quality of Life in Patients With Gastrointestinal-Related Neuroendocrine Tumors Unknown status NCT00454376 Phase 4
2 Correlation Between SV2A Expression in Tumour Tissue and Efficacy of Levetiracetam in Glioma Patients With Epilepsy Unknown status NCT00454935 Phase 4
3 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma Unknown status NCT00294177 Phase 4
4 Standard Palliative Care Versus Standard Palliative Care Plus Polychemotherapy in Metastasized Malignant Melanoma Unknown status NCT00226473 Phase 4
5 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4
6 Intravitreal Ranibizumab for the Prevention of Radiation Maculopathy Following Plaque Radiotherapy Unknown status NCT00540930 Phase 4
7 RAD001 With Paclitaxel and Carboplatin in First Line Treatment of Patients With Advanced Large Cell Lung Cancer With Neuroendocrine Differentiation Completed NCT01317615 Phase 4
8 Extension Study to the Open-label, Multi-center, Expanded Access Study of Everolimus in Patients With Advanced Neuroendocrine Tumors Completed NCT01595009 Phase 4
9 Efficacy of Prophylactic Itraconazole in High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation Completed NCT00336531 Phase 4
10 Somatuline Autogel Preference and Health Economy Study Completed NCT00681187 Phase 4
11 Can We Miss Pigmented Lesions in Psoriasis Patients? Completed NCT01053819 Phase 4
12 Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy Completed NCT01959711 Phase 4
13 Standard Temodal (Temozolomide) Regimen Versus Standard Regimen Plus Early Postsurgery Temodal for Newly Diagnosed Glioblastoma Multiforme (Study P05572) Completed NCT00686725 Phase 4
14 Effect of Topical Imiquimod on Lentigo Maligna Completed NCT01161888 Phase 4
15 Post-Operative Drainage Following Lymph Node Dissection Completed NCT00324272 Phase 4
16 Long Term Results of Combined Transpupillary Thermotherapy (TTT) Indocyanine Green (ICG) Based Photodynamic Therapy (PDT) in Choroidal Melanoma Completed NCT01253759 Phase 4
17 CEV With/Without Periocular Carboplatin Chemotherapy for Extraocular Retinoblastoma Completed NCT02319486 Phase 4
18 Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors Recruiting NCT01424839 Phase 4
19 HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors Recruiting NCT02875314 Phase 4
20 Radiolabeled Molecules for Medullary Thyroid Cancer Recruiting NCT01915485 Phase 4
21 Nonfunctional Pancreatic NET and PET Imaging Recruiting NCT02621541 Phase 4
22 A Study of Two Different Doses of Cabozantinib (XL184) in Progressive, Metastatic Medullary Thyroid Cancer Recruiting NCT01896479 Phase 4
23 Phase IV Study of the Safety and Efficacy of Everolimus in Adult Patients With Progressive pNET in China Recruiting NCT02842749 Phase 4
24 Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in a Novartis-sponsored Study. Recruiting NCT01794793 Phase 4
25 Supra-early Post-Surgery Chemotherapy in the Treatment on GBM Patients Recruiting NCT02520635 Phase 4
26 A Comparison of Single Versus Double Evacuation for Treatment of Hydatidiform Mole Recruiting NCT01630954 Phase 4
27 Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function Recruiting NCT02415257 Phase 4
28 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Recruiting NCT02379754 Phase 4
29 Neoadjuvant Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in Cutaneous Stage L-lll Melanoma Recruiting NCT02451488 Phase 4
30 Immune Modulation Study in Patients With Metastatic Melanoma Treated With Anti-PD1 Monoclonal Antibodies Recruiting NCT02626065 Phase 4
31 Phenoxybenzamine Versus Doxazosin in PCC Patients Recruiting NCT01379898 Phase 4
32 Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing Cream Recruiting NCT02685592 Phase 4
33 Circulating Tumour Cells in Somatuline Autogel Treated NeuroEndocrine Tumours Patients Active, not recruiting NCT02075606 Phase 4
34 Clinical Effectiveness of Serum Chromogranin A Levels on Diagnostic of Pancreatic Neuroendocrine Tumors Active, not recruiting NCT02759718 Phase 4
35 Stereotactic Body Radiotherapy for Head and Neck Tumors Active, not recruiting NCT01344356 Phase 4
36 A Study Of The Efficacy And Safety Of Sunitinib In Patients With Advanced Well-Differentiated Pancreatic Neuroendocrine Tumors Active, not recruiting NCT01525550 Phase 4
37 TTT Versus TTT and Triamcinolone to Decrease Exudation in Choroidal Melanoma After Proton Beam Therapy Active, not recruiting NCT02379000 Phase 4
38 Study of Lanreotide in Metastatic or Recurrent Grade I-II Hindgut NET Active, not recruiting NCT03083210 Phase 4
39 An Open-Label Study of Zelboraf (Vemurafenib) in Patients With Braf V600 Mutation Positive Metastatic Melanoma Active, not recruiting NCT01898585 Phase 4
40 A National Phase IV Study With Ipilimumab for Patients With Advanced Malignant Melanoma. Active, not recruiting NCT02068196 Phase 4
41 Phase 3 Trial in Subjects With Metastatic Melanoma Comparing 3 mg/kg Ipilimumab Versus 10 mg/kg Ipilimumab Active, not recruiting NCT01515189 Phase 4
42 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Not yet recruiting NCT02933333 Phase 4
43 Molecular Profiling and Matched Targeted Therapy for Patients With Metastatic Melanoma Not yet recruiting NCT02645149 Phase 4
44 Effect of Cytokine-induced Killer Cells for Advanced Malignant Gliomas Not yet recruiting NCT02496988 Phase 4
45 Seizure Treatment in Glioma Not yet recruiting NCT03048084 Phase 4
46 Post-approval Study of NovoTTF-100A in Recurrent GBM Patients Terminated NCT01756729 Phase 4
47 HD IL-2 + Ipilimumab in Patients With Metastatic Melanoma Terminated NCT01856023 Phase 4
48 HD IL-2 + Vemurafenib in Patients With BRAF Mutation Positive Metastatic Melanoma Terminated NCT01683188 Phase 4
49 Pasireotide Treatment for Neuroendocrine Tumor Withdrawn NCT02779257 Phase 4
50 Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors Unknown status NCT00002566 Phase 3

Search NIH Clinical Center for Testicular Germ Cell Tumor

Genetic Tests for Testicular Germ Cell Tumor

Genetic tests related to Testicular Germ Cell Tumor:

id Genetic test Affiliating Genes
1 Germ Cell Tumor 29
2 Germ Cell Tumor, Nonseminomatous 29

Anatomical Context for Testicular Germ Cell Tumor

MalaCards organs/tissues related to Testicular Germ Cell Tumor:

39
Testis, Ovary, Testis Germ, Lymph Node, Brain, Testes, Kidney

Publications for Testicular Germ Cell Tumor

Articles related to Testicular Germ Cell Tumor:

(show top 50) (show all 435)
id Title Authors Year
1
Reporting and Staging of Testicular Germ Cell Tumors: The International Society of Urological Pathology (ISUP) Testicular Cancer Consultation Conference Recommendations. ( 28368923 )
2017
2
Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy. ( 28266817 )
2017
3
Mosaic chromosome Y loss and testicular germ cell tumor risk. ( 28275244 )
2017
4
Future of testicular germ cell tumor incidence in the United States: Forecast through 2026. ( 28241106 )
2017
5
miRa89223a893p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors. ( 28000896 )
2017
6
Cutaneous Presentation of a Testicular Germ Cell Tumor With Seminomatous Differentiation. ( 28452794 )
2017
7
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor. ( 26917601 )
2016
8
Does the Serum Metallothionein Level Reflect the Stage of Testicular Germ Cell Tumor? ( 27255355 )
2016
9
Re: Ultrasound Demonstration of Testicular Microlithiasis in Pediatric Patients: Is There an Association with Testicular Germ Cell Tumors? ( 27321534 )
2016
10
MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients. ( 27517619 )
2016
11
Long-term Relative Survival after Diagnosis of Testicular Germ Cell Tumor. ( 26908435 )
2016
12
Right Cardiac Chambers Involvement by a Malignant Testicular Germ Cell Tumor: An Imaging-pathologic Correlation. ( 27017904 )
2016
13
Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor. ( 27863478 )
2016
14
A rare cause in etiology of left atrial mass: metastatic testicular germ cell tumor. ( 27212979 )
2016
15
Consumption of alcoholic beverages in adolescence and adulthood and risk of testicular germ cell tumor. ( 27474852 )
2016
16
Novel association of familial testicular germ cell tumor and autosomal dominant polycystic kidney disease with PKD1 mutation. ( 27577987 )
2016
17
Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway. ( 27158395 )
2016
18
A CASE OF ADVANCED NON-SEMINOMATOUS TESTICULAR GERM CELL TUMOR ACCOMPANIED PANIC DISORDER. ( 28132992 )
2016
19
Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors. ( 26654129 )
2016
20
Brain Metastases as Presenting Feature in 'Burned Out' Testicular Germ Cell Tumor. ( 27182465 )
2016
21
The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors. ( 27599467 )
2016
22
Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review. ( 27957372 )
2016
23
Familial testicular germ cell tumor with bilateral disease. ( 27072274 )
2016
24
MicroRNA miR-371a-3p - A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid. ( 26989896 )
2016
25
Wilms tumor gene 1 (WT1), TP53, RAS/BRAF and KIT aberrations in testicular germ cell tumors. ( 27085458 )
2016
26
Impact of Bep or Carboplatin Chemotherapy on Testicular Function and Sperm Nucleus of Subjects with Testicular Germ Cell Tumor. ( 27242529 )
2016
27
Testicular germ cell tumor: Short and long-term side effects of treatment among survivors. ( 27588190 )
2016
28
[Polymorphisms of KITLG, SPRY4, and BAK1 genes in patients with testicular germ cell tumors and individuals with infertility associated with AZFc deletion of the Y chromosome]. ( 28064312 )
2016
29
Sperm DNA Fragmentation Index and Hyaluronan Binding Ability in Men from Infertile Couples and Men with Testicular Germ Cell Tumor. ( 27999814 )
2016
30
Hotspot TERT promoter mutations are rare events in testicular germ cell tumors. ( 26526580 )
2016
31
Testicular germ cell tumor genomics. ( 27584029 )
2016
32
More Cases of Benign Testicular Teratomas are Detected in Adults than in Children. A Clinicopathological Study of 543 Testicular Germ Cell Tumor Cases. ( 27796764 )
2016
33
Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients. ( 27698832 )
2016
34
A novel prognostic factor TRIM44 promotes cell proliferation and migration, and inhibits apoptosis in testicular germ cell tumor. ( 27754579 )
2016
35
Identifying functional cancer-specific miRNA-mRNA interactions in testicular germ cell tumor. ( 27235586 )
2016
36
Disparities in Interpretation of Primary Testicular Germ Cell Tumor Pathology. ( 26185314 )
2015
37
The role of spermatogenesis-associated protein 6 in testicular germ cell tumors. ( 26464655 )
2015
38
Editorial Comment from Dr Beyer to Identification of a subgroup with worse prognosis among patients with poor-risk testicular germ cell tumor. ( 26105542 )
2015
39
Editorial Comment from Dr Nakamura to Identification of a subgroup with worse prognosis among patients with poor-risk testicular germ cell tumor. ( 26153458 )
2015
40
Frequent PD-L1 expression in testicular germ cell tumors. ( 26171934 )
2015
41
Nontesticular cancers in relatives of testicular germ cell tumor (TGCT) patients from multiple-case TGCT families. ( 25882629 )
2015
42
Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor. ( 25877299 )
2015
43
Re: Craniocaudal Retroperitoneal Node Length as a Risk Factor for Relapse from Clinical Stage I Testicular Germ Cell Tumor. ( 26582668 )
2015
44
Exome sequencing of bilateral testicular germ cell tumors suggests independent development lineages. ( 25748235 )
2015
45
Differential expression of Mediator complex subunit MED15 in testicular germ cell tumors. ( 26377566 )
2015
46
[IMMUNOHISTOCHEMICAL EXPRESSION OF UBIQUITIN PROTEIN IN PERITUMORAL TISSUE OF PATIENTS WITH TESTICULAR GERM CELL TUMORS]. ( 26118027 )
2015
47
Vasculogenesis and angiogenesis in nonseminomatous testicular germ cell tumors. ( 25772688 )
2015
48
Identification of a subgroup with worse prognosis among patients with poor-risk testicular germ cell tumor. ( 26094715 )
2015
49
Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis. ( 25791729 )
2015
50
Rare inactivating PDE11A variants associated with testicular germ cell tumors. ( 26459559 )
2015

Variations for Testicular Germ Cell Tumor

UniProtKB/Swiss-Prot genetic disease variations for Testicular Germ Cell Tumor:

66
id Symbol AA change Variation ID SNP ID
1 FGFR3 p.Lys650Glu VAR_004160 rs78311289
2 STK10 p.Lys277Glu VAR_023827 rs757545210
3 STK11 p.Gly163Asp VAR_033140 rs137853078

ClinVar genetic disease variations for Testicular Germ Cell Tumor:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 BCL10 NM_003921.4(BCL10): c.499dupT (p.Ser167Phefs) duplication Pathogenic rs387906350 GRCh37 Chromosome 1, 85733513: 85733513
2 BCL10 NM_003921.4(BCL10): c.172C> G (p.Arg58Gly) single nucleotide variant Pathogenic rs121918314 GRCh37 Chromosome 1, 85736475: 85736475
3 BCL10 NM_003921.4(BCL10): c.172C> T (p.Arg58Ter) single nucleotide variant Pathogenic rs121918314 GRCh37 Chromosome 1, 85736475: 85736475
4 STK11 NM_000455.4(STK11): c.488G> A (p.Gly163Asp) single nucleotide variant Pathogenic rs137853078 GRCh37 Chromosome 19, 1220395: 1220395
5 HRAS NM_005343.3(HRAS): c.181C> A (p.Gln61Lys) single nucleotide variant Pathogenic/Likely pathogenic rs28933406 GRCh37 Chromosome 11, 533875: 533875
6 KIT NM_000222.2(KIT): c.2446G> C (p.Asp816His) single nucleotide variant Pathogenic/Likely pathogenic rs121913506 GRCh37 Chromosome 4, 55599320: 55599320
7 BRAF NM_004333.4(BRAF): c.1799T> A (p.Val600Glu) single nucleotide variant Pathogenic/Likely pathogenic rs113488022 GRCh37 Chromosome 7, 140453136: 140453136
8 FGFR3 NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu) single nucleotide variant Pathogenic/Likely pathogenic rs78311289 GRCh37 Chromosome 4, 1807889: 1807889
9 BCL10 NM_003921.4(BCL10): c.488C> T (p.Thr163Met) single nucleotide variant Pathogenic rs370432633 GRCh37 Chromosome 1, 85733524: 85733524

Copy number variations for Testicular Germ Cell Tumor from CNVD:

7 (show all 12)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 19332 1 149600000 247249719 Gain Testicular germ cell tumor
2 42821 10 40300000 82000000 Loss Testicular germ cell tumor
3 61421 12 1 132349534 Gain Testicular germ cell tumor
4 89303 15 17000000 76100000 Loss Testicular germ cell tumor
5 121721 18 46400000 76117153 Loss Testicular germ cell tumor
6 146937 2 56300000 230700000 Loss Testicular germ cell tumor
7 180589 4 107900000 191273063 Loss Testicular germ cell tumor
8 206877 6 149100000 170899992 Loss Testicular germ cell tumor
9 226157 7 55086724 55275030 Amplification EGFR Testicular germ cell tumor
10 245111 9 101600000 129300000 Loss Testicular germ cell tumor
11 261703 X 24900000 29400000 Gain Testicular germ cell tumor
12 262543 X 37500000 146900000 Gain Testicular germ cell tumor

Expression for Testicular Germ Cell Tumor

Search GEO for disease gene expression data for Testicular Germ Cell Tumor.

Pathways for Testicular Germ Cell Tumor

Pathways related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 37)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 AKT1 BAK1 BAX ESR2 FGFR3 KIT
2
Show member pathways
13.37 AKT1 AR BAX FGFR3 KIT KITLG
3
Show member pathways
13.08 AKT1 FGFR3 KIT KITLG PTEN TP53
4
Show member pathways
13.01 AKT1 FGFR3 KIT KITLG PTEN TP53
5
Show member pathways
12.83 AKT1 AR BAX ESR2 FGFR3 GSTP1
6
Show member pathways
12.64 AKT1 BCL10 FGFR3 KIT KITLG PTEN
7 12.48 AKT1 FGFR3 KIT KITLG PTEN STK11
8
Show member pathways
12.46 AKT1 FGFR3 GPC3 PTEN STK11 TP53
9
Show member pathways
12.34 AKT1 BAX PTEN TP53
10
Show member pathways
12.31 AKT1 BAX KIT PTEN TP53
11
Show member pathways
12.21 AKT1 BAX PTEN TP53
12
Show member pathways
12.13 AKT1 FGFR3 PTEN TP53
13
Show member pathways
12.11 AKT1 KIT KITLG PTEN
14
Show member pathways
12.08 AKT1 BAX STK11 TP53
15 12.05 AKT1 BAX PTEN TP53
16 12.01 AFP BAK1 BAX PTEN TP53
17
Show member pathways
11.97 AKT1 BAK1 BAX TP53
18 11.94 AKT1 BAX PTEN TP53
19 11.89 AKT1 BAK1 BAX PTEN TP53
20 11.87 AKT1 AR BAX FGFR3 GSTP1 KIT
21 11.81 AKT1 AR PTEN
22 11.77 BAK1 BAX TP53
23 11.76 AKT1 PTEN TP53
24 11.76 AKT1 PTEN TP53
25 11.76 AKT1 BAK1 BAX PTEN STK11 TP53
26
Show member pathways
11.74 AKT1 BAX KIT
27 11.74 AFP AKT1 BAX TP53
28 11.69 AKT1 AR BAK1 BAX PTEN STK11
29 11.63 AKT1 PTEN TP53
30 11.63 AKT1 BAK1 BAX GSTP1 TP53
31 11.54 AKT1 PTEN TP53
32 11.51 BAK1 BAX TP53
33 11.47 AKT1 FGFR3 KIT PTEN TP53
34 11.44 AKT1 BAX PTEN TP53
35 11.33 BAK1 BAX TP53
36 11.09 AKT1 BAK1 BAX

GO Terms for Testicular Germ Cell Tumor

Cellular components related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.76 AKT1 BAK1 BAX ESR2 GSTP1 PTEN
2 cytoplasm GO:0005737 9.5 AFP AKT1 AR BAX BCL10 DMRT1
3 pore complex GO:0046930 8.96 BAK1 BAX

Biological processes related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.91 AKT1 BAK1 BAX BCL10 PTEN TP53
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.89 KITLG STK11 TP53
3 positive regulation of MAPK cascade GO:0043410 9.89 AR FGFR3 KIT
4 cellular response to insulin stimulus GO:0032869 9.88 AKT1 GSTP1 PTEN
5 negative regulation of cell proliferation GO:0008285 9.87 AR BAK1 BAX GPC3 PTEN STK11
6 cellular response to mechanical stimulus GO:0071260 9.86 AKT1 BAK1 BCL10
7 protein oligomerization GO:0051259 9.85 AR BAX BCL10
8 protein autophosphorylation GO:0046777 9.85 AKT1 FGFR3 KIT STK10 STK11
9 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.83 AKT1 ESR2 KIT PTEN
10 negative regulation of epithelial cell proliferation GO:0050680 9.82 AR GPC3 PTEN
11 negative regulation of ERK1 and ERK2 cascade GO:0070373 9.8 GSTP1 PTEN SPRY4
12 cellular response to UV GO:0034644 9.8 BAK1 BAX TP53
13 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.78 AKT1 FGFR3 KIT KITLG
14 ovarian follicle development GO:0001541 9.77 BAX KIT KITLG
15 response to gamma radiation GO:0010332 9.76 BAK1 BAX TP53
16 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.75 BAX STK11 TP53
17 negative regulation of fibroblast proliferation GO:0048147 9.73 BAX GSTP1 TP53
18 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.72 BAK1 BAX KITLG
19 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.71 BAK1 BAX
20 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.71 BAK1 BAX TP53
21 positive regulation of calcium ion transport into cytosol GO:0010524 9.7 BAK1 BAX
22 regulation of mitochondrial membrane permeability GO:0046902 9.7 BAK1 TP53
23 anoikis GO:0043276 9.7 AKT1 STK11
24 negative regulation of cell size GO:0045792 9.69 AKT1 PTEN
25 positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 9.69 FGFR3 KIT
26 myeloid cell homeostasis GO:0002262 9.68 BAK1 BAX
27 vagina development GO:0060068 9.68 BAK1 BAX
28 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 9.67 BAK1 BAX
29 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.67 BAK1 BAX
30 germ cell migration GO:0008354 9.67 DMRT1 KIT
31 sex differentiation GO:0007548 9.67 AR BAX DMRT1
32 activation of signaling protein activity involved in unfolded protein response GO:0006987 9.66 BAK1 BAX
33 positive regulation of IRE1-mediated unfolded protein response GO:1903896 9.66 BAK1 BAX
34 negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 9.65 BAK1 BAX
35 regulation of protein heterodimerization activity GO:0043497 9.65 BAK1 BAX
36 prostate gland growth GO:0060736 9.65 AR PTEN
37 male gonad development GO:0008584 9.65 AR BAX DMRT1 KIT KITLG
38 regulation of protein homodimerization activity GO:0043496 9.64 BAK1 BAX
39 response to fungus GO:0009620 9.63 BAK1 BCL10
40 positive regulation of endoplasmic reticulum unfolded protein response GO:1900103 9.62 BAK1 BAX
41 apoptotic process involved in blood vessel morphogenesis GO:1902262 9.61 BAK1 BAX
42 thymocyte apoptotic process GO:0070242 9.61 BAK1 BAX
43 cellular response to decreased oxygen levels GO:0036294 9.59 AKT1 PTEN
44 post-embryonic camera-type eye morphogenesis GO:0048597 9.57 BAK1 BAX
45 ectopic germ cell programmed cell death GO:0035234 9.54 BAX KIT KITLG
46 B cell negative selection GO:0002352 9.51 BAK1 BAX
47 cell proliferation GO:0008283 9.5 AKT1 AR BAK1 BAX KITLG PTEN
48 B cell apoptotic process GO:0001783 9.33 BAK1 BAX BCL10
49 phosphatidylinositol-mediated signaling GO:0048015 9.1 AKT1 FGFR3 KIT KITLG PTEN TP53
50 negative regulation of apoptotic process GO:0043066 10.11 AKT1 GSTP1 KITLG PTEN TP53

Molecular functions related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.55 AKT1 BCL10 GSTP1 PTEN TP53
2 chaperone binding GO:0051087 9.54 BAK1 BAX TP53
3 identical protein binding GO:0042802 9.5 AKT1 BAK1 BAX BCL10 PTEN STK10
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.43 FGFR3 KIT KITLG
5 enzyme binding GO:0019899 9.1 AKT1 AR BCL10 ESR2 PTEN TP53
6 protein binding GO:0005515 10.25 AFP AKT1 AR BAK1 BAX BCL10

Sources for Testicular Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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