MCID: TST003
MIFTS: 32

Testicular Leukemia

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Testicular Leukemia

MalaCards integrated aliases for Testicular Leukemia:

Name: Testicular Leukemia 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12286
NCIt 47 C9277
UMLS 69 C1336711

Summaries for Testicular Leukemia

MalaCards based summary : Testicular Leukemia is related to leukemia and anterolateral myocardial infarction. An important gene associated with Testicular Leukemia is MAGEA4 (MAGE Family Member A4), and among its related pathways/superpathways are Kit receptor signaling pathway and TGF-beta Receptor Signaling (WikiPathways). The drugs Bleomycin and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells.

Related Diseases for Testicular Leukemia

Diseases related to Testicular Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 leukemia 10.2
2 anterolateral myocardial infarction 9.9 POU5F1 TFAP2C
3 uremia 9.7 POU5F1 WT1
4 childhood leukemia 9.5
5 monocytic leukemia 9.5
6 acute lymphocytic leukemia 9.5
7 acute monocytic leukemia 9.5
8 lymphoblastic leukemia 9.5
9 atypical depressive disorder 6.0 CCR3 CD9 FOS JPT1 MAGEA4 POU5F1

Graphical network of the top 20 diseases related to Testicular Leukemia:



Diseases related to Testicular Leukemia

Symptoms & Phenotypes for Testicular Leukemia

Drugs & Therapeutics for Testicular Leukemia

Drugs for Testicular Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 238)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved Phase 3 11056-06-7 5360373
2
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
3
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
4
Etoposide Approved Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
5
Ifosfamide Approved Phase 3 3778-73-2 3690
6
Vinblastine Approved Phase 3 865-21-4 13342 241903
7
Asparaginase Approved Phase 3 9015-68-3
8
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
9
Cytarabine Approved, Investigational Phase 3 147-94-4 6253
10
Daunorubicin Approved Phase 3 20830-81-3 30323
11
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
12
Doxorubicin Approved, Investigational Phase 3,Phase 1,Phase 2 23214-92-8 31703
13
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
14
Pegaspargase Approved, Investigational Phase 3 130167-69-0
15
Thioguanine Approved Phase 3 154-42-7 2723601
16
Vincristine Approved, Investigational Phase 3,Phase 1,Phase 2 2068-78-2, 57-22-7 5978
17
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754 657311
18
Idarubicin Approved Phase 3 58957-92-9 42890
19
Levoleucovorin Approved Phase 3 68538-85-2
20
Mechlorethamine Approved Phase 3 51-75-2 4033
21
Mesna Approved Phase 3 3375-50-6 598
22
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
23
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
24
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1 53-03-2 5865
25
Lenograstim Approved Phase 3,Phase 1 135968-09-1
26
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
27
Ofloxacin Approved Phase 3 82419-36-1 4583
28
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
29
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
30
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
31
Palivizumab Approved, Investigational Phase 3 188039-54-5
32
Ribavirin Approved Phase 3 36791-04-5 37542
33
Fluconazole Approved Phase 3 86386-73-4 3365
34
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
35
Captopril Approved Phase 3 62571-86-2 44093
36
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
37
Dasatinib Approved, Investigational Phase 3,Phase 1,Phase 2 302962-49-8 3062316
38
Busulfan Approved, Investigational Phase 3,Phase 2,Early Phase 1 55-98-1 2478
39
Cortisone acetate Approved Phase 3 1950-04-4, 50-04-4 5745
40
Clofarabine Approved, Investigational Phase 3,Phase 2 123318-82-1 119182
41
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
42
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
43
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
44
Norgestimate Approved Phase 3 35189-28-7 6540478
45
Cyproheptadine Approved Phase 3 129-03-3 2913
46
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
47
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
48
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 143 6006
49
Doxil Approved June 1999 Phase 3,Phase 1,Phase 2 31703
50
Butyric Acid Experimental Phase 3 107-92-6 264

Interventional clinical trials:

(show top 50) (show all 111)

id Name Status NCT ID Phase Drugs
1 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
2 Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005945 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
3 Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00002816 Phase 3 cytarabine;dexamethasone;etoposide;idarubicin;ifosfamide;leucovorin calcium;mesna;pegaspargase;therapeutic hydrocortisone;thioguanine;vincristine sulfate;Methotrexate
4 Dexamethasone Compared With Prednisone During Induction Therapy and MTX With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed NCT00075725 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
5 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
6 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
7 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
8 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
9 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
10 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
11 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
12 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
13 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
14 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
15 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Active, not recruiting NCT00408005 Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Leucovorin Calcium;Mercaptopurine;Methotrexate;Nelarabine;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
16 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations Suspended NCT02883049 Phase 3 Clofarabine;Cyclophosphamide;Cytarabine;Dasatinib;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
17 Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia Terminated NCT00002961 Phase 3 cyclophosphamide;cyclosporine;etoposide;methotrexate;Busulfan;Mesna
18 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
19 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
20 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2 brentuximab vedotin
21 High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma Completed NCT01177371 Phase 2 busulfan;cyclophosphamide;methylprednisolone;methotrexate;cyclosporine
22 Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies Completed NCT01427881 Phase 2 cyclophosphamide;cyclosporine;fludarabine phosphate;busulfan
23 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
24 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
25 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
26 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
27 Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation Completed NCT00064311 Phase 1, Phase 2 ravuconazole
28 High-Dose Chemotherapy, Total-Body Irradiation, and Autologous Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Hematologic Cancer or Solid Tumors Completed NCT00060255 Phase 2 busulfan;carboplatin;carmustine;cyclophosphamide;etoposide;melphalan;thiotepa
29 Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant Completed NCT00410657 Phase 2 methylprednisolone;prednisone
30 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2 ondansetron
31 Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer Completed NCT00118352 Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
32 Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies Completed NCT01273766 Phase 2 deferasirox
33 Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies Completed NCT01789255 Phase 2 vorinostat;tacrolimus;cyclosporine;methotrexate
34 Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors Completed NCT01326702 Phase 1, Phase 2 Bendamustine Hydrochloride;Veliparib
35 Haploidentical Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancer Completed NCT00049504 Phase 2 cyclophosphamide;fludarabine phosphate;tacrolimus;mycophenolate mofetil
36 Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma Completed NCT01258998 Phase 2 Akt inhibitor MK2206
37 Gemcitabine Hydrochloride, Carboplatin, Dexamethasone, and Rituximab in Treating Patients With Previously Treated Lymphoid Malignancies Completed NCT00072514 Phase 2 gemcitabine hydrochloride;carboplatin;dexamethasone
38 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
39 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
40 Oblimersen Sodium and Rituximab in Treating Patients With Recurrent B-cell Non-Hodgkin Lymphoma Completed NCT00054639 Phase 2
41 Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies Recruiting NCT01643603 Phase 1, Phase 2 Dasatinib
42 Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies Recruiting NCT01760655 Phase 2 Fludarabine phosphate;Thiotepa;Cyclophosphamide;Tacrolimus;Mycophenolate mofetil
43 Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Recruiting NCT01839916 Phase 2
44 Lenalidomide and Combination Chemotherapy (DA-EPOCH-R) in Treating Patients With MYC-Associated B-Cell Lymphomas Recruiting NCT02213913 Phase 1, Phase 2 lenalidomide;etoposide;prednisone;vincristine sulfate;doxorubicin hydrochloride;cyclophosphamide
45 Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer Active, not recruiting NCT00006251 Phase 1, Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
46 Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancer Active, not recruiting NCT00089011 Phase 2 fludarabine phosphate;mycophenolate mofetil;tacrolimus
47 Rituximab in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant for Relapsed or Refractory B-cell Lymphoma Active, not recruiting NCT00867529 Phase 2
48 Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage II or Stage III Testicular or Ovarian Cancer Terminated NCT00042952 Phase 2 imatinib mesylate
49 Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant Terminated NCT01419795 Phase 2 lenalidomide
50 Ipilimumab and Local Radiation Therapy in Treating Patients With Recurrent Melanoma, Non-Hodgkin Lymphoma, Colon, or Rectal Cancer Terminated NCT01769222 Phase 1, Phase 2

Search NIH Clinical Center for Testicular Leukemia

Genetic Tests for Testicular Leukemia

Anatomical Context for Testicular Leukemia

MalaCards organs/tissues related to Testicular Leukemia:

39
Bone, Bone Marrow, B Cells, T Cells, Colon, Testes, Liver

Publications for Testicular Leukemia

Articles related to Testicular Leukemia:

(show all 19)
id Title Authors Year
1
Relapsed testicular leukemia: local insights in to a vanishing disease. ( 20448368 )
2010
2
Testicular leukemia inhibitory factor (LIF) and LIF receptor mediate phosphorylation of signal transducers and activators of transcription (STAT)-3 and STAT-1 and induce c-fos transcription and activator protein-1 activation in rat Sertoli but not germ cells. ( 9528974 )
1998
3
Testicular leukemia relapse. Fine needle aspiration findings. ( 9568129 )
1998
4
Needle biopsy in the diagnosis of testicular leukemia in children. ( 2709505 )
1989
5
Occult testicular leukemia in a patient with acute monocytic leukemia. ( 3152942 )
1987
6
The enigma of testicular leukemia: a critical review. ( 3537653 )
1986
7
Treatment of murine testicular leukemia. ( 6722788 )
1984
8
Management of children with isolated testicular leukemia. ( 6498764 )
1984
9
Incidence and detection of testicular leukemia in children. ( 6590152 )
1984
10
Ultrasound diagnosis of testicular leukemia. ( 6571758 )
1983
11
The ultrasound diagnosis of testicular leukemia. ( 6400260 )
1983
12
Diagnosis of testicular leukemia. ( 7201513 )
1982
13
Isolated testicular leukemia following bone marrow transplant for acute lymphocytic leukemia. The need for pretransplant testicular biopsies. ( 7046495 )
1982
14
Proceedings of the tumor board of the Children's Hospital of Philadelphia. Testicular leukemia: incidence and management results. ( 6946280 )
1981
15
Occult testicular leukemia: testicular biopsy at three years continuous complete remission of childhood leukemia: a Southwest Oncology Group Study. ( 6939470 )
1981
16
Clinical and occult testicular leukemia in long-term survivors of acute lymphoblastic leukemia. ( 6928464 )
1980
17
Radiotherapy (2500 rad) for testicular leukemia: local control and subsequent clinical events: a Southwest Oncology Group study. ( 6994868 )
1980
18
Testicular leukemia. ( 5461011 )
1970
19
Testicular leukemia. ( 5413403 )
1970

Variations for Testicular Leukemia

Expression for Testicular Leukemia

Search GEO for disease gene expression data for Testicular Leukemia.

Pathways for Testicular Leukemia

Pathways related to Testicular Leukemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.01 CCR3 FOS STAT1
2 10.92 FOS STAT1
3 10.63 FOS STAT1

GO Terms for Testicular Leukemia

Biological processes related to Testicular Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.8 FOS POU5F1 PREB STAT1 TFAP2C WT1
2 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.56 POU5F1 STAT1 TFAP2C WT1
3 response to cytokine GO:0034097 9.37 FOS STAT1
4 transcription from RNA polymerase II promoter GO:0006366 9.26 FOS POU5F1 TFAP2C WT1
5 response to cAMP GO:0051591 9.16 FOS STAT1
6 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.02 FOS POU5F1 STAT1 TFAP2C WT1

Molecular functions related to Testicular Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.43 FOS POU5F1 PREB STAT1 TFAP2C WT1
2 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 9.33 FOS TFAP2C WT1
3 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.26 FOS STAT1
4 transcription factor activity, sequence-specific DNA binding GO:0003700 9.02 FOS POU5F1 STAT1 TFAP2C WT1

Sources for Testicular Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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