MCID: TST004
MIFTS: 33

Testicular Lymphoma malady

Immune diseases, Reproductive diseases categories

Summaries for Testicular Lymphoma

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32MalaCards
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MalaCards: Testicular Lymphoma, also known as malignant lymphoma of testis, is related to anaplastic large cell lymphoma and central nervous system lymphoma. An important gene associated with Testicular Lymphoma is PTPRC (protein tyrosine phosphatase, receptor type, C), and among its related pathways are Immune response Fc epsilon RI pathway and Lymphocyte Signaling. The compounds cycloheximide and 12-o-tetradecanoylphorbol 13-acetate have been mentioned in the context of this disorder. Affiliated tissues include testis, b cells and bone.

Aliases & Classifications for Testicular Lymphoma

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Sources:
8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Reproductive diseases


Aliases & Descriptions:

testicular lymphoma 8 10 30
malignant lymphoma of testis 8 60
lymphoma of the testis 8


External Ids:

Disease Ontology8 DOID:12253
SNOMED-CT56 277664004
NCIt39 C6810

Related Diseases for Testicular Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Testicular Lymphoma:



Diseases related to testicular lymphoma

Clinical Features for Testicular Lymphoma

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Drugs & Therapeutics for Testicular Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Testicular Lymphoma

Drug clinical trials:

Search ClinicalTrials for Testicular Lymphoma

Search NIH Clinical Center for Testicular Lymphoma

Search CenterWatch for Testicular Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Testicular Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Testicular Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Testicular Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Testicular Lymphoma

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Anatomical Context for Testicular Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Testicular Lymphoma:

32
Testis, B cells, Bone, T cells, Brain, Prostate, B lymphoblasts, Bone marrow

Animal Models for Testicular Lymphoma or affiliated genes

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Publications for Testicular Lymphoma

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50PubMed
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Articles related to Testicular Lymphoma:

(show top 50)    (show all 108)
idTitleAuthorsYear
1
Primary testicular lymphoma. (24282217)
2014
2
Isolated primary testicular B lymphoblastic lymphoma: an unusual presentation. (23042023)
2013
3
Primary testicular non-Hodgkin lymphoma. a 10-year Tunisian single-institute experience. (24008876)
2013
4
An unusual presentation of Hodgkin's lymphoma: ectopic testicular involvement. (24012625)
2013
5
The impact of systemic chemotherapy on testicular FDG activity in young men with Hodgkin's lymphoma. (23389428)
2013
6
Scrotal irradiation in primary testicular lymphoma: review of the literature and in silico planning comparative study. (22836054)
2013
7
Clinical Features of Testicular Lymphoma. (24247653)
2013
8
Three prognostic factors influence clinical outcomes of primary testicular lymphoma. (22965883)
2013
9
Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma. (23680437)
2013
10
Primary testicular lymphoma: experience with 13 cases and literature review. (23355262)
2013
11
Intraocular (vitreoretinal) lymphoma following primary testicular lymphoma. (23931497)
2013
12
Huge testicular lymphoma on 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography-computed tomography. (23187303)
2013
13
Primary testicular diffuse large B-cell lymphoma: A case report focusing on touch imprint cytology and a non-germinal center B-cell-like phenotype. (23935714)
2013
14
Primary testicular lymphoma. (22424983)
2012
15
FDG PET/CT of bilateral testicular lymphoma. (22157041)
2012
16
Clinics in diagnostic imaging (134). Testicular lymphoma. (21451930)
2011
17
Relapsed testicular lymphoma presenting with cranial nerve neurolymphomatosis. (21502608)
2011
18
Primary testicular lymphoma. (20872294)
2010
19
Testicular lymphoma. (21167372)
2010
20
Aggressive nasal-type natural killer/T-cell lymphoma associated with Epstein Barr virus presenting as testicular tumor. (20415195)
2010
21
Primary testicular lymphoma: a strictly homogeneous hematological disease? (20372839)
2010
22
Primary testicular lymphoma with extranodal involvement. (19736380)
2009
23
Extranodal CD20-positive peripheral T-cell lymphoma presenting with adrenal and testicular masses. (19483402)
2009
24
Primary testicular lymphoma involving the spermatic cord and gonadal vein. (19300051)
2009
25
Primary testicular presentation of ALK-1-negative anaplastic large cell lymphoma in a pediatric patient. (19415011)
2009
26
Rituximab and dose-dense chemotherapy in primary testicular lymphoma. (19858059)
2009
27
Consideration of aggressive therapeutic strategies for primary testicular lymphoma. (17563078)
2007
28
Primary testicular non-Hodgkin's lymphoma with atrial mass as an initial presentation of acquired immunodeficiency syndrome. (17676218)
2007
29
Primary testicular lymphoma. (18020104)
2007
30
Testicular lymphoma--a retrospective, population-based, clinical and immunohistochemical study. (15764222)
2004
31
Multipoint methylation analysis indicates a distinctive epigenetic phenotype among testicular germ cell tumors and testicular malignant lymphomas. (12874790)
2003
32
Multiple renal cystic lesions and acute renal failure in non-Hodgkin's testicular lymphoma--a case report. (12739837)
2003
33
Testicular lymphoma: a mysterious link between the testis and the brain. (12521395)
2002
34
Testicular disease in childhood B-cell non-Hodgkin's lymphoma: the French Society of Pediatric Oncology experience. (11331318)
2001
35
Testicular lymphoma is associated with a high risk of extranodal recurrence. (10931479)
2000
36
Testicular lymphoma is associated with a high incidence of extranodal recurrence. (10618618)
2000
37
Testicular lymphoma with bone/bone marrow metastases illustrated by scrotal sonography, spinal MRI, and total body Tc-99m HMDP and Tc-99m MIBI images. (10582797)
1999
38
Primary testicular lymphoma. (9834575)
1998
39
Lack of adhesion molecules in testicular diffuse centroblastic and immunoblastic B cell lymphomas as a contributory factor in malignant behaviour. (8917708)
1996
40
Testicular lymphoma: late relapses and poor outcome despite doxorubicin-based therapy. (7751880)
1995
41
Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study. (7819053)
1995
42
Testicular lymphoma: a population-based study of incidence, clinicopathological correlations and prognosis. The Danish Lymphoma Study Group, LYFO. (7880601)
1994
43
Urinary retention due to prostatic involvement in testicular lymphoma: a case report. (8256685)
1993
44
An unusual manifestation of testicular lymphoma. (1641214)
1992
45
Acquired immunodeficiency syndrome presenting as testicular lymphoma. (1552601)
1992
46
A sonographic appearance of testicular lymphoma. (2036761)
1991
47
Testicular lymphoma: sonographic findings. (3885539)
1985
48
Bilateral malignant testicular lymphoma. (6642548)
1983
49
Testicular lymphoma. A retrospective review of 17 cases. (6689088)
1983
50
Malignant testicular lymphoma in brothers. (938872)
1976

Genetic Variations for Testicular Lymphoma

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Expression for genes affiliated with Testicular Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Testicular Lymphoma

Search GEO for disease gene expression data for Testicular Lymphoma.

Pathways for genes affiliated with Testicular Lymphoma

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Sources:
12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database
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Pathways related to Testicular Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1BCL6, PTPRC
29.1BCL6, PTPRC
39.1BCL6, PTPRC

Compounds for genes affiliated with Testicular Lymphoma

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44Novoseek
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Compounds related to Testicular Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cycloheximide449.1BCL6, PTPRC
212-o-tetradecanoylphorbol 13-acetate449.0BCL6, PTPRC
3paraffin448.8BCL6, PTPRC

GO Terms for genes affiliated with Testicular Lymphoma

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16Gene Ontology
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Biological processes related to Testicular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:0308909.1BCL6, PTPRC

Products for genes affiliated with Testicular Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Testicular Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet