MCID: TST004
MIFTS: 30

Testicular Lymphoma malady

Immune, Reproductive categories

Summaries for Testicular Lymphoma

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33MalaCards
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MalaCards: Testicular Lymphoma, also known as malignant lymphoma of testis, is related to follicular lymphoma and lymphoma, diffuse large cell. An important gene associated with Testicular Lymphoma is PTPRC (protein tyrosine phosphatase, receptor type, C), and among its related pathways are Immune response Fc epsilon RI pathway and Lymphocyte Signaling. The compounds cycloheximide and 12-o-tetradecanoylphorbol 13-acetate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone marrow.

Aliases & Classifications for Testicular Lymphoma

Sources:
8Disease Ontology, 10DISEASES, 31LifeMap Discovery™, 61UMLS, 40NCIt, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune, Reproductive


Aliases & Descriptions:

testicular lymphoma 8 10 31
malignant lymphoma of testis 8 61
lymphoma of the testis 8


External Ids:

Disease Ontology8 DOID:12253
SNOMED-CT57 277664004
NCIt40 C6810

Related Diseases for Testicular Lymphoma

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Testicular Lymphoma:



Diseases related to testicular lymphoma

Clinical Features for Testicular Lymphoma

Drugs & Therapeutics for Testicular Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Testicular Lymphoma

Drug clinical trials:

Search ClinicalTrials for Testicular Lymphoma

Search NIH Clinical Center for Testicular Lymphoma

Search CenterWatch for Testicular Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Testicular Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Testicular Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Testicular Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Testicular Lymphoma

Anatomical Context for Testicular Lymphoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Testicular Lymphoma:

33
Spinal cord, Brain, Bone marrow, Prostate, Testis, T cells, B lymphoblasts, B cells, Testis germ

Animal Models for Testicular Lymphoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Testicular Lymphoma

Sources:
51PubMed
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Articles related to Testicular Lymphoma:

(show top 50)    (show all 109)
idTitleAuthorsYear
1
Cutaneous diffuse large B-cell lymphoma, leg type, secondary to testicular diffuse large B-cell lymphoma. (24354909)
2013
2
F18 FDG positron emission tomography revelation of primary testicular lymphoma with concurrent multiple extra nodal involvement. (24019676)
2013
3
Isolated primary testicular B lymphoblastic lymphoma: an unusual presentation. (23042023)
2013
4
Primary testicular non-Hodgkin lymphoma. a 10-year Tunisian single-institute experience. (24008876)
2013
5
The impact of systemic chemotherapy on testicular FDG activity in young men with Hodgkin's lymphoma. (23389428)
2013
6
Diffuse large B-cell lymphoma in immunoprivileged sites: association of vitreoretinal, testicular and central nervous system lymphoma. (23819861)
2013
7
Scrotal irradiation in primary testicular lymphoma: review of the literature and in silico planning comparative study. (22836054)
2013
8
Testicular lymphoma. (23945480)
2013
9
High prevalence of oncogenic MYD88 and CD79B mutations in primary testicular diffuse large B-cell lymphoma. (24253023)
2013
10
Primary testicular lymphoma with rupture: An unusual presentation. (23633871)
2013
11
Primary testicular lymphoma: experience with 13 cases and literature review. (23355262)
2013
12
Phenotype profiling of primary testicular diffuse large B-cell lymphomas. (23949965)
2013
13
Primary testicular diffuse large B-cell lymphoma: A case report focusing on touch imprint cytology and a non-germinal center B-cell-like phenotype. (23935714)
2013
14
Primary testicular non-Hodgkin's lymphoma associated with hemophagocytic syndrome: Case report and review of the literature. (22807960)
2012
15
Primary testicular lymphoma. (22424983)
2012
16
Primary testicular lymphoma with cardiac involvement in an immunocompetent patient: case report and a concise review of literature. (23087799)
2012
17
Primary testicular lymphoma: the site matters. (20497004)
2010
18
Aggressive nasal-type natural killer/T-cell lymphoma associated with Epstein Barr virus presenting as testicular tumor. (20415195)
2010
19
Primary testicular lymphoma with extranodal involvement. (19736380)
2009
20
Extranodal CD20-positive peripheral T-cell lymphoma presenting with adrenal and testicular masses. (19483402)
2009
21
Primary testicular lymphoma involving the spermatic cord and gonadal vein. (19300051)
2009
22
Primary testicular presentation of ALK-1-negative anaplastic large cell lymphoma in a pediatric patient. (19415011)
2009
23
Rituximab and dose-dense chemotherapy in primary testicular lymphoma. (19858059)
2009
24
Testicular lymphoma: an update for clinicians. (18854677)
2008
25
Primary testicular lymphoma. (17962036)
2008
26
Sperm aneuploidy frequencies analysed before and after chemotherapy in testicular cancer and Hodgkin's lymphoma patients. (18083744)
2008
27
Consideration of aggressive therapeutic strategies for primary testicular lymphoma. (17563078)
2007
28
Primary testicular non-Hodgkin's lymphoma with atrial mass as an initial presentation of acquired immunodeficiency syndrome. (17676218)
2007
29
Primary testicular precursor B-lymphoblastic lymphoma: a rare entity. (17852709)
2007
30
Testicular lymphoma: a case report. (18159836)
2007
31
The relationship between HLA class II polymorphisms and somatic deletions in testicular B cell lymphomas of Dutch patients. (16720210)
2006
32
Imaging diagnosis of testicular lymphoma. (16465583)
2006
33
Array comparative genomic hybridization reveals a very high frequency of deletions of the long arm of chromosome 6 in testicular lymphoma. (16865685)
2006
34
Multipoint methylation analysis indicates a distinctive epigenetic phenotype among testicular germ cell tumors and testicular malignant lymphomas. (12874790)
2003
35
Testicular natural killer/t-cell lymphoma, nasal type, of true natural killer-cell origin. (12456216)
2002
36
Deletion 5p11 accompanied by multiple numerical changes in testicular lymphoma. (11734324)
2001
37
Bilateral testicular lymphoma treated with chemotherapy and radiation without orchiectomy: complete response relapsed at 52 months in the vitreous humor. (11248646)
2001
38
A case of bilateral testicular lymphoma. (10393369)
1999
39
Testicular lymphoma. (10375083)
1999
40
Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study. (7819053)
1995
41
Urinary retention due to prostatic involvement in testicular lymphoma: a case report. (8256685)
1993
42
An unusual manifestation of testicular lymphoma. (1641214)
1992
43
Acquired immunodeficiency syndrome presenting as testicular lymphoma. (1552601)
1992
44
Testicular lymphoma with pancreatitis. (2041014)
1991
45
A sonographic appearance of testicular lymphoma. (2036761)
1991
46
Sonographic appearance of primary testicular lymphoma. (1950870)
1991
47
Primary testicular lymphoma with central nervous system involvement. (1870344)
1991
48
Testicular lymphoma. A retrospective review of 17 cases. (6689088)
1983
49
Testicular lymphoma: a clinicopathologic study of 22 cases. (581582)
1978
50
Malignant testicular lymphoma in brothers. (938872)
1976

Genetic Variations for Testicular Lymphoma

Expression for genes affiliated with Testicular Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Testicular Lymphoma

Search GEO for disease gene expression data for Testicular Lymphoma.

Pathways for genes affiliated with Testicular Lymphoma

Sources:
12EMD Millipore, 4Cell Signaling Technology, 38NCBI BioSystems Database
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Pathways related to Testicular Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1BCL6, PTPRC
29.1BCL6, PTPRC
39.1BCL6, PTPRC

Compounds for genes affiliated with Testicular Lymphoma

Sources:
45Novoseek
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Compounds related to Testicular Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cycloheximide459.1BCL6, PTPRC
212-o-tetradecanoylphorbol 13-acetate459.0BCL6, PTPRC
3paraffin458.8BCL6, PTPRC

GO Terms for genes affiliated with Testicular Lymphoma

Sources:
16Gene Ontology
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Biological processes related to Testicular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:0308909.1BCL6, PTPRC

Products for genes affiliated with Testicular Lymphoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Testicular Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet