MCID: TST004
MIFTS: 37

Testicular Lymphoma malady

Categories: Cancer diseases, Reproductive diseases, Immune diseases

Aliases & Classifications for Testicular Lymphoma

Aliases & Descriptions for Testicular Lymphoma:

Name: Testicular Lymphoma 38 12 14
Malignant Lymphoma of Testis 12 69
Lymphoma of the Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12253
NCIt 47 C6810
SNOMED-CT 64 277664004
UMLS 69 C0349644

Summaries for Testicular Lymphoma

MalaCards based summary : Testicular Lymphoma, also known as malignant lymphoma of testis, is related to lymphoma and akinetopsia. An important gene associated with Testicular Lymphoma is MYD88 (Myeloid Differentiation Primary Response 88), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Dendritic Cells Developmental Lineage Pathway. The drugs Levofloxacin and Ofloxacin have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and b cells.

Related Diseases for Testicular Lymphoma

Graphical network of the top 20 diseases related to Testicular Lymphoma:



Diseases related to Testicular Lymphoma

Symptoms & Phenotypes for Testicular Lymphoma

Drugs & Therapeutics for Testicular Lymphoma

Drugs for Testicular Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 239)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
2
Ofloxacin Approved Phase 3 82419-36-1 4583
3
Asparaginase Approved Phase 3 9015-68-3
4
Cytarabine Approved, Investigational Phase 3,Phase 2 147-94-4 6253
5
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
6
Etoposide Approved Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
7
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754 657311
8
Idarubicin Approved Phase 3 58957-92-9 42890
9
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
10
Levoleucovorin Approved Phase 3 68538-85-2
11
Mechlorethamine Approved Phase 3,Phase 1,Phase 2 51-75-2 4033
12
Mesna Approved Phase 3 3375-50-6 598
13
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
14
Pegaspargase Approved, Investigational Phase 3 130167-69-0
15
Thioguanine Approved Phase 3 154-42-7 2723601
16
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
17
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
18
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
19
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
20
Palivizumab Approved, Investigational Phase 3 188039-54-5
21
Ribavirin Approved Phase 3 36791-04-5 37542
22
Fluconazole Approved Phase 3 86386-73-4 3365
23
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
24
Captopril Approved Phase 3 62571-86-2 44093
25
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
26
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
27
Daunorubicin Approved Phase 3 20830-81-3 30323
28
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
29
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
30
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
31
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1 53-03-2 5865
32
Ondansetron Approved Phase 3,Phase 2 99614-02-5 4595
33
Dasatinib Approved, Investigational Phase 3,Phase 1,Phase 2 302962-49-8 3062316
34
Mycophenolate mofetil Approved, Investigational Phase 3,Phase 2,Phase 1 128794-94-5 5281078
35
Mycophenolic acid Approved Phase 3,Phase 2,Phase 1 24280-93-1 446541
36
Busulfan Approved, Investigational Phase 3,Phase 2,Early Phase 1 55-98-1 2478
37
Cyclosporine Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
38
Clofarabine Approved, Investigational Phase 3,Phase 2 123318-82-1 119182
39
Cortisone acetate Approved Phase 3 1950-04-4, 50-04-4 5745
40
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757 53477783
41
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
42
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
43
Norgestimate Approved Phase 3 35189-28-7 6540478
44
Cyproheptadine Approved Phase 3 129-03-3 2913
45
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
46
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
47
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 54575, 6560146 143
48
Butyric Acid Experimental Phase 3 107-92-6 264
49
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
50 Antirheumatic Agents Phase 3,Phase 1,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 135)
id Name Status NCT ID Phase
1 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3
2 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3
3 Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00002816 Phase 3
4 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
5 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3
6 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3
7 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3
8 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3
9 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
10 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
11 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3
12 Dexamethasone Compared With Prednisone During Induction Therapy and MTX With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed NCT00075725 Phase 3
13 Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005945 Phase 3
14 Ondansetron With or Without Dexamethasone to Prevent Vomiting in Patients Receiving Radiation Therapy to the Upper Abdomen Completed NCT00016380 Phase 3
15 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations Recruiting NCT02883049 Phase 3
16 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Active, not recruiting NCT00408005 Phase 3
17 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3
18 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
19 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3
20 Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia Terminated NCT00002961 Phase 3
21 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2
22 Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors Completed NCT01326702 Phase 1, Phase 2
23 Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma Completed NCT01258998 Phase 2
24 Oblimersen Sodium and Rituximab in Treating Patients With Recurrent B-cell Non-Hodgkin Lymphoma Completed NCT00054639 Phase 2
25 High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma Completed NCT01177371 Phase 2
26 Gemcitabine Hydrochloride, Carboplatin, Dexamethasone, and Rituximab in Treating Patients With Previously Treated Lymphoid Malignancies Completed NCT00072514 Phase 2
27 Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies Completed NCT01427881 Phase 2
28 Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies Completed NCT01789255 Phase 2
29 Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer Completed NCT00118352 Phase 2
30 Haploidentical Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancer Completed NCT00049504 Phase 2
31 Phase II Study of Combined Modality Treatment in Primary Testicular Non-Hodgkin's Lymphoma Completed NCT00210379 Phase 2
32 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
33 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2
34 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
35 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
36 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2
37 Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation Completed NCT00064311 Phase 1, Phase 2
38 High-Dose Chemotherapy, Total-Body Irradiation, and Autologous Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Hematologic Cancer or Solid Tumors Completed NCT00060255 Phase 2
39 Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant Completed NCT00410657 Phase 2
40 Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer Completed NCT00002515 Phase 2
41 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2
42 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
43 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2
44 Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant Completed NCT00357084 Phase 2
45 Safety and Feasibility Study of Combination of State of Art Chemoimmunotherapy, Intensive Central Nervous System Prophylaxis and Scrotal Irradiation to Treat Primary Diffuse Large B-cell Lymphoma of Testis Recruiting NCT00945724 Phase 2
46 Lenalidomide and Combination Chemotherapy (DA-EPOCH-R) in Treating Patients With MYC-Associated B-Cell Lymphomas Recruiting NCT02213913 Phase 1, Phase 2
47 Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Recruiting NCT01839916 Phase 2
48 Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies Recruiting NCT01760655 Phase 2
49 Dasatinib for Modulating Immune System After Autologous Stem Cell Transplants for Multiple Myeloma, Non-Hodgkin, or Hodgkin Lymphoma Recruiting NCT01609816 Phase 1, Phase 2
50 Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies Recruiting NCT01643603 Phase 1, Phase 2

Search NIH Clinical Center for Testicular Lymphoma

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Testicular Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Testicular Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Testicular Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Testicular Lymphoma

Anatomical Context for Testicular Lymphoma

MalaCards organs/tissues related to Testicular Lymphoma:

39
Testis, Bone, B Cells, Brain, Prostate, Bone Marrow

Publications for Testicular Lymphoma

Articles related to Testicular Lymphoma:

(show top 50) (show all 89)
id Title Authors Year
1
Straight Vessel Pattern and Rapid Filling Time: Characteristic Findings on Contrast-Enhanced Sonography of Testicular Lymphoma. ( 27335443 )
2016
2
Primary testicular lymphoma. ( 26433344 )
2015
3
Primary testicular lymphoma with solitary cutaneous nodule as the initial presentation. ( 26664513 )
2015
4
Primary testicular lymphoma: Two case reports and review of the literature. ( 26766810 )
2015
5
High prevalence of the MYD88 mutation in testicular lymphoma: Immunohistochemical and genetic analyses. ( 26388135 )
2015
6
Primary testicular lymphoma: a single centre experience. ( 26422109 )
2015
7
Isolated Central Nervous System Relapse After 10A Years in a Case of Primary Testicular Lymphoma Detected on (18)F-FDG PET/CT. ( 26550055 )
2015
8
Primary testicular lymphoma. ( 25444963 )
2015
9
Various neurological symptoms by neurolymphomatosis as the initial presentation of primary testicular lymphoma. ( 26034480 )
2015
10
Unusual continuous intra-abdominal spread of primary testicular lymphoma along the spermatic cord and gonadal vessels: Report of 2 cases. ( 26649126 )
2015
11
Grayscale and color Doppler features of testicular lymphoma. ( 26014335 )
2015
12
Recurrent genomic rearrangements in primary testicular lymphoma. ( 25712539 )
2015
13
Primary testicular lymphoma. ( 24282217 )
2014
14
Single-center experience in the treatment of primary testicular lymphoma. ( 24853782 )
2014
15
Bilateral primary testicular lymphoma. ( 24692378 )
2014
16
Primary testicular lymphoma with subcutaneous masses as the sole manifestation of the first relapse and central nervous system lymphoma as the second relapse: A case report and literature review. ( 24932252 )
2014
17
Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma. ( 23680437 )
2013
18
Testicular lymphoma. ( 23945480 )
2013
19
Clinical Features of Testicular Lymphoma. ( 24247653 )
2013
20
Huge testicular lymphoma on 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography-computed tomography. ( 23187303 )
2013
21
Primary testicular lymphoma: experience with 13 cases and literature review. ( 23355262 )
2013
22
F18 FDG positron emission tomography revelation of primary testicular lymphoma with concurrent multiple extra nodal involvement. ( 24019676 )
2013
23
Primary testicular lymphoma with rupture: An unusual presentation. ( 23633871 )
2013
24
Three prognostic factors influence clinical outcomes of primary testicular lymphoma. ( 22965883 )
2013
25
Scrotal irradiation in primary testicular lymphoma: review of the literature and in silico planning comparative study. ( 22836054 )
2013
26
Intraocular (vitreoretinal) lymphoma following primary testicular lymphoma. ( 23931497 )
2013
27
FDG PET/CT of bilateral testicular lymphoma. ( 22157041 )
2012
28
Primary diffuse large B-cell testicular lymphoma: magnetic resonance imaging findings. ( 21988565 )
2012
29
Primary testicular lymphoma. ( 22424983 )
2012
30
Primary testicular lymphoma with cardiac involvement in an immunocompetent patient: case report and a concise review of literature. ( 23087799 )
2012
31
Clinics in diagnostic imaging (134). Testicular lymphoma. ( 21451930 )
2011
32
Relapsed testicular lymphoma presenting with cranial nerve neurolymphomatosis. ( 21502608 )
2011
33
Testicular lymphoma, intraocular (vitreoretinal) lymphoma, and brain lymphoma: involvement of three immunoprivileged sites in one patient. ( 20658596 )
2010
34
Testicular lymphoma. ( 21167372 )
2010
35
Primary testicular lymphoma: the site matters. ( 20497004 )
2010
36
Primary testicular lymphoma: a strictly homogeneous hematological disease? ( 20372839 )
2010
37
Primary testicular lymphoma. ( 20872294 )
2010
38
Primary testicular lymphoma involving the spermatic cord and gonadal vein. ( 19300051 )
2009
39
Primary testicular lymphoma with extranodal involvement. ( 19736380 )
2009
40
Rituximab and dose-dense chemotherapy in primary testicular lymphoma. ( 19858059 )
2009
41
Primary testicular lymphoma. ( 17962036 )
2008
42
Testicular lymphoma: an update for clinicians. ( 18854677 )
2008
43
Intraocular lymphoma following a primary testicular lymphoma in remission for 10 years. ( 17985076 )
2008
44
Primary testicular lymphoma. ( 17945289 )
2007
45
Primary testicular lymphoma. ( 18020104 )
2007
46
Testicular lymphoma: a case report. ( 18159836 )
2007
47
Multiple cranial nerve palsies in testicular lymphoma: report of a case. ( 17622916 )
2007
48
Consideration of aggressive therapeutic strategies for primary testicular lymphoma. ( 17563078 )
2007
49
Imaging diagnosis of testicular lymphoma. ( 16465583 )
2006
50
Primary testicular lymphoma--A case report. ( 16910327 )
2006

Variations for Testicular Lymphoma

Expression for Testicular Lymphoma

Search GEO for disease gene expression data for Testicular Lymphoma.

Pathways for Testicular Lymphoma

Pathways related to Testicular Lymphoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.32 MME PTPRC
2 11.04 MME PTPRC
3 10.68 MME PTPRC
4 10.17 MME PTPRC

GO Terms for Testicular Lymphoma

Cellular components related to Testicular Lymphoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 secretory granule membrane GO:0030667 8.62 MME PTPRC

Biological processes related to Testicular Lymphoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of inflammatory response GO:0050727 9.16 FOXP1 MYD88
2 positive regulation of smooth muscle cell proliferation GO:0048661 8.96 FOXP1 MYD88
3 regulation of tumor necrosis factor production GO:0032680 8.62 FOXP1 MYD88

Molecular functions related to Testicular Lymphoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein self-association GO:0043621 8.62 FOXP1 MYD88

Sources for Testicular Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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