MCID: TST004
MIFTS: 36

Testicular Lymphoma malady

Cancer diseases, Immune diseases, Reproductive diseases categories
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Summaries for Testicular Lymphoma

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33MalaCards
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MalaCards: Testicular Lymphoma, also known as malignant lymphoma of testis, is related to follicular lymphoma and anaplastic large cell lymphoma. An important gene associated with Testicular Lymphoma is PTPRC (protein tyrosine phosphatase, receptor type, C), and among its related pathways are Immune response Fc epsilon RI pathway and Lymphocyte Signaling. The compounds 12-o-tetradecanoylphorbol 13-acetate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and brain, and related mouse phenotypes are respiratory system and liver/biliary system.

Aliases & Classifications for Testicular Lymphoma

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Sources:
8Disease Ontology, 10DISEASES, 31LifeMap Discovery™, 62UMLS, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases, Reproductive diseases


Aliases & Descriptions:

testicular lymphoma 8 10 31
malignant lymphoma of testis 8 62
lymphoma of the testis 8


External Ids:

Disease Ontology8 DOID:12253
SNOMED-CT58 277664004
NCIt40 C6810

Related Diseases for Testicular Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Testicular Lymphoma:



Diseases related to testicular lymphoma

Symptoms for Testicular Lymphoma

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Drugs & Therapeutics for Testicular Lymphoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
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Drug clinical trials:

Search ClinicalTrials for Testicular Lymphoma

Search NIH Clinical Center for Testicular Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Testicular Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Testicular Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Testicular Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Testicular Lymphoma

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Anatomical Context for Testicular Lymphoma

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33MalaCards
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MalaCards organs/tissues related to Testicular Lymphoma:

33
Testis, Bone, Brain, Prostate, B cells, Bone marrow

Animal Models for Testicular Lymphoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Testicular Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.1BCL6, PTPRC
2MP:00053709.0BCL6, PTPRC
3MP:00030128.8BCL6, PTPRC

Publications for Testicular Lymphoma

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Sources:
52PubMed
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Articles related to Testicular Lymphoma:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
F18 FDG positron emission tomography revelation of primary testicular lymphoma with concurrent multiple extra nodal involvement. (24019676)
2013
2
Scrotal irradiation in primary testicular lymphoma: review of the literature and in silico planning comparative study. (22836054)
2013
3
Clinical Features of Testicular Lymphoma. (24247653)
2013
4
Three prognostic factors influence clinical outcomes of primary testicular lymphoma. (22965883)
2013
5
Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma. (23680437)
2013
6
Testicular lymphoma. (23945480)
2013
7
Primary testicular lymphoma with rupture: An unusual presentation. (23633871)
2013
8
Primary testicular lymphoma: experience with 13 cases and literature review. (23355262)
2013
9
Primary testicular lymphoma. (22424983)
2012
10
FDG PET/CT of bilateral testicular lymphoma. (22157041)
2012
11
Clinics in diagnostic imaging (134). Testicular lymphoma. (21451930)
2011
12
Relapsed testicular lymphoma presenting with cranial nerve neurolymphomatosis. (21502608)
2011
13
Primary testicular lymphoma. (20872294)
2010
14
Testicular lymphoma. (21167372)
2010
15
Testicular lymphoma, intraocular (vitreoretinal) lymphoma, and brain lymphoma: involvement of three immunoprivileged sites in one patient. (20658596)
2010
16
Primary testicular lymphoma: the site matters. (20497004)
2010
17
Primary testicular lymphoma with extranodal involvement. (19736380)
2009
18
Primary testicular lymphoma involving the spermatic cord and gonadal vein. (19300051)
2009
19
Rituximab and dose-dense chemotherapy in primary testicular lymphoma. (19858059)
2009
20
Testicular lymphoma: an update for clinicians. (18854677)
2008
21
Intraocular lymphoma following a primary testicular lymphoma in remission for 10 years. (17985076)
2008
22
Primary testicular lymphoma. (17962036)
2008
23
Consideration of aggressive therapeutic strategies for primary testicular lymphoma. (17563078)
2007
24
Multiple cranial nerve palsies in testicular lymphoma: report of a case. (17622916)
2007
25
Primary testicular lymphoma. (18020104)
2007
26
Diagnosis of a primary testicular lymphoma by echography and magnetic resonance imaging. (16790401)
2006
27
Imaging diagnosis of testicular lymphoma. (16465583)
2006
28
Array comparative genomic hybridization reveals a very high frequency of deletions of the long arm of chromosome 6 in testicular lymphoma. (16865685)
2006
29
Testicular lymphoma--a retrospective, population-based, clinical and immunohistochemical study. (15764222)
2004
30
Testicular lymphoma: organ-specific treatment did not improve outcome. (15557780)
2004
31
Testicular lymphoma: a mysterious link between the testis and the brain. (12521395)
2002
32
Outcome and patterns of failure in testicular lymphoma: a multicenter Rare Cancer Network study. (11849786)
2002
33
Testicular lymphoma: a literature review and report of a case with a zoster-like cutaneous recurrence. (11970763)
2002
34
Combined systemic and intrathecal chemotherapy plus radiotherapy in testicular lymphoma: a report of two cases. (11940507)
2002
35
Deletion 5p11 accompanied by multiple numerical changes in testicular lymphoma. (11734324)
2001
36
Bilateral testicular lymphoma treated with chemotherapy and radiation without orchiectomy: complete response relapsed at 52 months in the vitreous humor. (11248646)
2001
37
A case of bilateral testicular lymphoma. (10393369)
1999
38
Primary testicular lymphoma. (9834575)
1998
39
Testicular lymphoma: late relapses and poor outcome despite doxorubicin-based therapy. (7751880)
1995
40
Testicular lymphoma: a population-based study of incidence, clinicopathological correlations and prognosis. The Danish Lymphoma Study Group, LYFO. (7880601)
1994
41
Urinary retention due to prostatic involvement in testicular lymphoma: a case report. (8256685)
1993
42
An unusual manifestation of testicular lymphoma. (1641214)
1992
43
AIDS presenting as primary testicular lymphoma. (1502756)
1992
44
Testicular lymphoma--the need for a new approach. (1763988)
1991
45
Testicular lymphoma: improved outcome with early brief chemotherapy. (3367185)
1988
46
Testicular lymphoma: sonographic findings. (3885539)
1985
47
Bilateral malignant testicular lymphoma. (6642548)
1983
48
Testicular lymphoma: a clinicopathologic study of 22 cases. (581582)
1978
49
Malignant testicular lymphoma in brothers. (938872)
1976
50
Testicular lymphoma. (1090055)
1975

Variations for Testicular Lymphoma

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Expression for genes affiliated with Testicular Lymphoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Testicular Lymphoma

Search GEO for disease gene expression data for Testicular Lymphoma.

Pathways for genes affiliated with Testicular Lymphoma

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Sources:
50PathCards, 60Thomson Reuters, 54R&D Systems, 30KEGG, 38NCBI BioSystems Database, 5Cell Signaling Technology
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Pathways related to Testicular Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.1BCL6, PTPRC
29.1BCL6, PTPRC
39.1BCL6, PTPRC

Compounds for genes affiliated with Testicular Lymphoma

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45Novoseek
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Compounds related to Testicular Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
112-o-tetradecanoylphorbol 13-acetate459.1BCL6, PTPRC
2estrogen459.1BCL6, PTPRC
3paraffin459.0BCL6, PTPRC
4cycloheximide458.8BCL6, PTPRC

GO Terms for genes affiliated with Testicular Lymphoma

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16Gene Ontology
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Biological processes related to Testicular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:0308909.1BCL6, PTPRC

Products for genes affiliated with Testicular Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Testicular Lymphoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet