MCID: TST025
MIFTS: 28

Testicular Microlithiasis

Categories: Reproductive diseases

Aliases & Classifications for Testicular Microlithiasis

MalaCards integrated aliases for Testicular Microlithiasis:

Name: Testicular Microlithiasis 53 28 13 69

Classifications:



External Ids:

OMIM 53 610441
MedGen 39 C1864873
SNOMED-CT via HPO 65 117261000119108
UMLS 69 C1864873

Summaries for Testicular Microlithiasis

OMIM : 53 Testicular microlithiasis, the deposition of calcium phosphate microliths within the seminiferous tubules, has a population prevalence of 0.6 to 9% (Kim et al., 2003). Middleton et al. (2002) found that it was associated with a majority of primary testicular malignancies. Miller and Sidhu (2002) found that it was present in 1% of male idiopathic infertility cases. (610441)

MalaCards based summary : Testicular Microlithiasis is related to germ cells tumors and testicular cancer. An important gene associated with Testicular Microlithiasis is SLC34A2 (Solute Carrier Family 34 Member 2). Affiliated tissues include testes, testis and appendix.

Wikipedia : 72 Testicular microlithiasis is an unusual condition diagnosed on testicular ultrasound. It is found in... more...

Related Diseases for Testicular Microlithiasis

Diseases related to Testicular Microlithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 germ cells tumors 10.4
2 testicular cancer 10.4
3 seminoma 10.3
4 infertility 10.3
5 testicular germ cell tumor 10.2
6 testicular germ cell tumor 1 10.2
7 mediastinitis 10.2
8 cryptorchidism, unilateral or bilateral 10.2
9 mccune-albright syndrome 10.0
10 down syndrome 10.0
11 mixed germ cell tumor 10.0
12 lipoid congenital adrenal hyperplasia 10.0
13 aging 10.0
14 male infertility 10.0
15 adrenal rest tumor 10.0
16 teratocarcinoma 10.0
17 precocious puberty 10.0
18 testicular seminoma 10.0
19 epidermoid cysts 9.8
20 lentigines 9.8
21 leopard syndrome 1 9.8
22 ruvalcaba syndrome 9.8
23 pseudoxanthoma elasticum 9.8
24 pulmonary alveolar microlithiasis 9.8
25 body mass index quantitative trait locus 11 9.8
26 fragile x syndrome 9.8
27 ichthyosis, x-linked 9.8
28 body mass index quantitative trait locus 9 9.8
29 body mass index quantitative trait locus 8 9.8
30 body mass index quantitative trait locus 7 9.8
31 body mass index quantitative trait locus 12 9.8
32 body mass index quantitative trait locus 14 9.8
33 episodic pain syndrome, familial, 1 9.8
34 body mass index quantitative trait locus 18 9.8
35 burns 9.8
36 thalassemia 9.8
37 fibrous dysplasia 9.8
38 hypogonadotropic hypogonadism 9.8
39 varicocele 9.8
40 leiomyoma 9.8
41 ichthyosis 9.8
42 calcinosis 9.8
43 endodermal sinus tumor 9.8
44 hypogonadism 9.8
45 orchitis 9.8
46 cystic teratoma 9.8
47 teratoma 9.8
48 sertoli cell tumor 9.8
49 choriocarcinoma 9.8
50 adenoma 9.8

Graphical network of the top 20 diseases related to Testicular Microlithiasis:



Diseases related to Testicular Microlithiasis

Symptoms & Phenotypes for Testicular Microlithiasis

Clinical features from OMIM:

610441

Human phenotypes related to Testicular Microlithiasis:

31
# Description HPO Frequency HPO Source Accession
1 testicular microlithiasis 31 HP:0012215

Drugs & Therapeutics for Testicular Microlithiasis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Identification of Predictive Markers for Testis Cancer in a Population of Men With High Risk Terminated NCT00820287

Search NIH Clinical Center for Testicular Microlithiasis

Genetic Tests for Testicular Microlithiasis

Genetic tests related to Testicular Microlithiasis:

# Genetic test Affiliating Genes
1 Testicular Microlithiasis 28 SLC34A2

Anatomical Context for Testicular Microlithiasis

MalaCards organs/tissues related to Testicular Microlithiasis:

38
Testes, Testis, Appendix, Adrenal Gland, Spleen

Publications for Testicular Microlithiasis

Articles related to Testicular Microlithiasis:

(show top 50) (show all 226)
# Title Authors Year
1
Adolescent testicular microlithiasis: A case-based, multinational survey of clinical management practices. ( 29428360 )
2018
2
A case of Riley Ruvalcaba syndrome with a novel PTEN mutation accompanied by diffuse testicular microlithiasis and precocious puberty. ( 29194042 )
2018
3
Characteristics of symptomatic men with testicular microlithiasis - A Danish cross-sectional questionnaire study. ( 28267895 )
2017
4
Testicular Adrenal Rests Tumors and Testicular Microlithiasis in a Brazilian Case Series with Classic Congenital Adrenal Hyperplasia. ( 28835760 )
2017
5
Shear wave elastography evaluation in pediatric testicular microlithiasis: a comparative study. ( 29075915 )
2017
6
Role of calcifying nanoparticles in the development of testicular microlithiasis in vivo. ( 29084530 )
2017
7
Bilateral methachronous testicular germ cell tumor and testicular microlithiasis in a child: Genetic analysis and insights. A case report. ( 29040905 )
2017
8
Pediatric Testicular Microlithiasis: To Refer or Not to Refer? ( 29051915 )
2017
9
Association between Testicular Microlithiasis and Testicular Neoplasia: Large Multicenter Study in a Pediatric Population. ( 28715257 )
2017
10
Comparison of Tissue Stiffness Using Shear Wave Elastography in Men with Normal Testicular Tissue, Testicular Microlithiasis and Testicular Cancer. ( 29276802 )
2017
11
Testicular microlithiasis is associated with ethnicity and socioeconomic status. ( 28815058 )
2017
12
Prevalence and Chronological Changes of Testicular Microlithiasis in Isolated Congenital Undescended Testes Operated On at Less Than 3 Years of Age. ( 28780301 )
2017
13
Testicular microlithiasis and testicular cancer: review of the literature. ( 27007613 )
2016
14
Inter- and intraobserver agreement in detection of testicular microlithiasis with ultrasonography. ( 26419255 )
2016
15
Testicular Microlithiasis: What Should You Recommend? ( 27058778 )
2016
16
Testicular Microlithiasis in the Setting of Primary Extragonadal Germ Cell Tumor: A Case Series. ( 27599309 )
2016
17
Testicular microlithiasis and preliminary experience of acoustic radiation force impulse imaging. ( 27504193 )
2016
18
Re: Ultrasound Demonstration of Testicular Microlithiasis in Pediatric Patients: Is There an Association with Testicular Germ Cell Tumors? ( 27321534 )
2016
19
Unilateral testicular microlithiasis: a rare paediatric incidental finding. ( 27613265 )
2016
20
How should we monitor boys with testicular microlithiasis? ( 27007453 )
2016
21
Testicular microlithiasis: Correlation with doppler sonography of testicular arteries and sperm function. ( 27120130 )
2016
22
Double Para-testicular Cellular Angiofibroma and Synchronous Testicular Microlithiasis. ( 26265690 )
2016
23
Re: Testicular Microlithiasis Imaging and Follow-up: Guidelines of the ESUR Scrotal Imaging Subcommittee. ( 27597076 )
2016
24
Long-Term Follow-Up of Testicular Microlithiasis in Children and Adolescents: Multicenter Prospective Cohort Study of the Italian Society of Pediatric Urology. ( 26962678 )
2016
25
The influence of testicular microlithiasis on the outcomes of in vitro fertilisation in a Chinese Han population. ( 27882628 )
2016
26
Testicular Microlithiasis: Patient Compliance in a Two-Year Follow-Up Program. ( 27921092 )
2016
27
A Meta-Analysis of the Relationship between Testicular Microlithiasis and Incidence of Testicular Cancer. ( 25923148 )
2015
28
Partial Orchiectomy for the Treatment of a Benign Sclerosing Sertoli Cell Tumor: A Report of a Rare Tumor in Association With Testicular Microlithiasis. ( 26793488 )
2015
29
Changes of calcific density in pediatric patients with testicular microlithiasis. ( 25874046 )
2015
30
Testicular Microlithiasis: Is Sonographic Surveillance Necessary? Single Centre 14 Year Experience in 442 Patients with Testicular Microlithiasis. ( 25654622 )
2015
31
Incidence of testicular microlithiasis in patients with I^-thalassemia major. ( 26251156 )
2015
32
Attributable risk calculations for testicular microlithiasis. ( 25502584 )
2015
33
Testicular microlithiasis and associated testicular malignancies in childhood: a systematic review. ( 25417839 )
2015
34
Re: Testicular Microlithiasis: Is there a Need for Surveillance in the Absence of Other Risk Factors? ( 24331488 )
2014
35
Testicular microlithiasis in children and associated testicular cancer. ( 24475810 )
2014
36
Should Patients with Down Syndrome be Screened for Testicular Microlithiasis? ( 24705995 )
2014
37
Testicular microlithiasis an ultrasound dilemma: survey of opinions regarding significance and management amongst UK ultrasound practitioners. ( 24311562 )
2014
38
A case report of transverse testicular ectopia with testicular microlithiasis. ( 25380032 )
2014
39
Ultrasound demonstration of testicular microlithiasis in pediatric patients: is there an association with testicular germ cell tumors? ( 24026852 )
2014
40
Testicular microlithiasis and dyspermia: is there any correlation? ( 24704926 )
2014
41
Testicular microlithiasis imaging and follow-up: guidelines of the ESUR scrotal imaging subcommittee. ( 25316054 )
2014
42
Testicular microlithiasis: prevalence and association with primary testicular neoplasm. ( 24585495 )
2014
43
Re: germ cell tumor in an adolescent with extensive testicular microlithiasis: concerns regarding future management, and re: clinical aspects of testicular microlithiasis in boys: a review. ( 25280322 )
2014
44
The association between testicular microlithiasis and semen parameters in Chinese adult men with fertility intention: experience of 226 cases. ( 25129542 )
2014
45
Testicular microlithiasis. ( 24684881 )
2014
46
Coexistence of testicular microlithiasis with parathyroid adenoma in an obese child. ( 24030026 )
2014
47
Testicular microlithiasis in acquired undescended testis after orchidopexy at diagnosis. ( 24106044 )
2013
48
Incidental discovery of testicular microlithiasis: what is the importance of ultrasound surveillance? Two case reports. ( 24348387 )
2013
49
Detection of the deletion of the STS gene and flanking sequences using polymerase chain reaction in a Chinese pedigree: the first case report of X-linked ichthyosis associated with testicular microlithiasis. ( 24126298 )
2013
50
Significant testicular enlargement in a 6.5-year-old boy with monorchism and testicular microlithiasis. ( 23640955 )
2013

Variations for Testicular Microlithiasis

Expression for Testicular Microlithiasis

Search GEO for disease gene expression data for Testicular Microlithiasis.

Pathways for Testicular Microlithiasis

GO Terms for Testicular Microlithiasis

Biological processes related to Testicular Microlithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 8.62 AFP SLC34A2

Sources for Testicular Microlithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....