Testicular Microlithiasis malady

Wikipedia: Testicular microlithiasis is an unusual condition diagnosed on testicular ultrasound. It is found in...⁴⁴ more...

MalaCards: Testicular Microlithiasis is related to central nervous system germ cell tumor and extragonadal germ cell tumor. An important gene associated with Testicular Microlithiasis is SLC34A2 (solute carrier family 34 (sodium phosphate), member 2). The compounds oestriol and clomiphene citrate have been mentioned in the context of this disorder.

OMIM: 610441

testicular microlithiasis 33 43

Diseases related to testicular microlithiasis by text searches and GeneDecks gene sharing:

(show all 26)

id	Related Disease	Score	Top Affiliating Genes
1	central nervous system germ cell tumor	12.5	AFP, CGB
2	extragonadal germ cell tumor	12.5	CGB, AFP
3	nonseminomatous germ cell tumor	12.5	AFP, CGB
4	mature teratoma	12.5	AFP, CGB
5	endodermal sinus tumor	12.5	AFP, CGB
6	germinoma	12.5	CGB, AFP
7	sertoli cell tumor	12.4	AFP, CGB
8	dysgerminoma	12.4	AFP, CGB
9	ectopic pregnancy	12.4	AFP, CGB
10	down syndrome	12.4	CGB, AFP
11	leydig cell tumor	12.4	CGB, AFP
12	familial male-limited precocious puberty	12.4	AFP, CGB
13	diabetes insipidus	12.4	AFP, CGB
14	neural tube defect	12.4	AFP, CGB
15	teratoma	12.3	AFP, CGB
16	mediastinitis	12.3	AFP, CGB
17	pediatric cns embryonal cell carcinoma	12.3	AFP, CGB
18	testicular cancer	12.2	CGB, AFP
19	spontaneous abortion	12.1	AFP, CGB
20	pre-eclampsia	12.1	CGB, AFP
21	seminoma	12.0	CGB, AFP
22	testicular germ cell tumor	11.8	CGB, AFP
23	lung carcinoma	11.1	CGB, GALNT3, AFP, SLC34A2
24	calcinosis	6.9
25	familial tumoral calcinosis	6.9
26	pulmonary alveolar microlithiasis	6.9

Clinical features from OMIM: 610441

Approved drugs:

Drug clinical trials:

Articles related to testicular microlithiasis:

id	Title	Authors	Year	Affiliating Genes
1	Testicular microlithiasis: a report of 2 cases and r eview of the literature (17569257)	Zhang Q.... Zhang D.	2007	AFP
2	Familial tumoral calcinosis and testicular microlithiasis associated with a new mutation of GALNT3 in a white family. (16567474)	Campagnoli M.F.... Ramenghi U.	2006	GALNT3
3	Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis. (16960801)	Corut A.... Tolun A.	2006	SLC34A2
4	Multi-institutional study of testicular microlithiasi s in childhood: a benign or premalignant condition? (9719297)	Furness P.D.... Cheng E.Y.	1998	CGB

Genes related to testicular microlithiasis according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	SLC34A2	solute carrier family 34 (sodium phosphate), member 2	11.0	Publications
2	GALNT3	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	11.0	Publications
3	CGB	chorionic gonadotropin, beta polypeptide	11.0	Publications
4	AFP	alpha-fetoprotein	11.0	Publications

Compounds related to testicular microlithiasis according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	oestriol32	9.3	AFP, CGB
2	clomiphene citrate32	9.3	AFP, CGB
3	ifosfamide32 9 9	11.3	AFP, CGB
4	bleomycin32 9 9	11.2	AFP, CGB
5	mifepristone32 42 9 9	12.2	CGB, AFP
6	vincristine32 34 9 9	12.1	CGB, AFP
7	methotrexate32 34 42 9 9	13.1	CGB, AFP
8	cyclophosphamide32 34 9 9	12.0	CGB, AFP
9	thyroxine32 18	9.8	CGB, AFP