MCID: TST037
MIFTS: 34

Testicular Sex Cord-Stromal Tumor malady

Cancer diseases, Rare diseases, Reproductive diseases categories
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Summaries for Testicular Sex Cord-Stromal Tumor

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MalaCards based summary: Testicular Sex Cord-Stromal Tumor, also known as sex cord-stromal tumor of the testis, is related to sex cord-gonadal stromal tumor and melanotic neuroectodermal tumor. An important gene associated with Testicular Sex Cord-Stromal Tumor is SYP (synaptophysin), and among its related pathways are Nuclear signaling by ERBB4 and Cell adhesion Cell matrix glycoconjugates. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include testis, and related mouse phenotype normal.

Aliases & Classifications for Testicular Sex Cord-Stromal Tumor

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Sources:
48Orphanet, 62UMLS, 26ICD10 via Orphanet
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Testicular Sex Cord-Stromal Tumor, Aliases & Descriptions:

Name: Testicular Sex Cord-Stromal Tumor 48 62
 
Sex Cord-Stromal Tumor of the Testis 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Reproductive diseases


External Ids:

ICD10 via Orphanet26 C62

Related Diseases for Testicular Sex Cord-Stromal Tumor

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Diseases related to Testicular Sex Cord-Stromal Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1sex cord-gonadal stromal tumor29.4VIM, DES, PGR, MUC1, CEACAM5, ALPP
2melanotic neuroectodermal tumor10.5SYP
3infantile myofibromatosis10.5DES
4dysembryoplastic neuroepithelial tumor10.5SYP
5rosai-dorfman disease10.4S100B
6hidradenoma10.4MUC1
7adenomatoid tumor10.4VIM
82q37 deletion syndrome10.4
9papillary ependymoma10.3S100B, SYP
10subependymal giant cell astrocytoma10.3S100B, SYP
11olfactory neuroblastoma10.3SYP, S100B
12syringoma10.3S100B, MUC1
13fibrous meningioma10.3S100B, MUC1
14pineocytoma10.3SYP, S100B
15desmoplastic small round cell tumor10.3DES, MUC1
16cutaneous fibrous histiocytoma10.3S100B, DES
17ganglioneuroblastoma10.3S100B, SYP
18anaplastic ependymoma10.3MUC1, S100B
19cystadenocarcinoma10.3MUC1, CEACAM5
20merkel cell carcinoma10.3MUC1, SYP
21male breast cancer10.3SYP, PGR
22ganglioglioma10.3S100B, SYP
23lung cancer10.2MUC1, SYP
24ganglioneuroma10.2S100B, SYP
25adenosarcoma10.2DES, PGR
26epithelioid leiomyosarcoma10.2VIM, DES
27mammary paget's disease10.2PGR, MUC1
28pseudosarcomatous fibromatosis10.2DES, VIM
29secretory meningioma10.2VIM, MUC1
30lymphangioleiomyomatosis10.2PGR, DES
31sertoli-leydig cell tumor10.2MUC1, PGR
32papillary adenocarcinoma10.2MUC1, CEACAM5
33alveolar soft part sarcoma10.2VIM, DES
34pilocytic astrocytoma10.2S100B, SYP
35clear cell ependymoma10.2VIM, MUC1
36large cell carcinoma10.2SYP, CEACAM5
37fibroma10.2DES, VIM
38myoepithelioma10.2VIM, S100B
39epithelioid sarcoma10.2VIM, MUC1
40choroid plexus papilloma10.2MUC1, SYP, S100B
41malignant mixed mullerian tumor10.2PGR, VIM
42hemangioblastoma10.1S100B, SYP, MUC1
43phyllode tumor10.1VIM, PGR
44cervical adenocarcinoma10.1PGR, CEACAM5
45medulloblastoma10.1SYP, S100B, DES
46paraganglioma10.1S100B, SYP
47malignant pleural mesothelioma10.1CEACAM5, MUC1
48malignant peripheral nerve sheath tumor10.1VIM, S100B
49mucoepidermoid carcinoma10.1MUC1, CEACAM5
50angiosarcoma10.1VIM, MUC1

Graphical network of the top 20 diseases related to Testicular Sex Cord-Stromal Tumor:



Diseases related to testicular sex cord-stromal tumor

Symptoms for Testicular Sex Cord-Stromal Tumor

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Drugs & Therapeutics for Testicular Sex Cord-Stromal Tumor

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Drug clinical trials:

Search ClinicalTrials for Testicular Sex Cord-Stromal Tumor

Search NIH Clinical Center for Testicular Sex Cord-Stromal Tumor

Genetic Tests for Testicular Sex Cord-Stromal Tumor

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Anatomical Context for Testicular Sex Cord-Stromal Tumor

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MalaCards organs/tissues related to Testicular Sex Cord-Stromal Tumor:

32
Testis

Animal Models for Testicular Sex Cord-Stromal Tumor or affiliated genes

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MGI Mouse Phenotypes related to Testicular Sex Cord-Stromal Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.9S100B, ALPP, SYP, MUC1, PGR

Publications for Testicular Sex Cord-Stromal Tumor

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Articles related to Testicular Sex Cord-Stromal Tumor:

idTitleAuthorsYear
1
Testicular sex cord-stromal tumor in a boy with 2q37 deletion syndrome. (24755370)
2014
2
Biphasic malignant testicular sex cord-stromal tumor in a cotton-top tamarin (Saguinus oedipus) with review of the literature. (18984797)
2008
3
Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. (9591732)
1998
4
Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. (9720507)
1998

Variations for Testicular Sex Cord-Stromal Tumor

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Expression for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Expression patterns in normal tissues for genes affiliated with Testicular Sex Cord-Stromal Tumor

Search GEO for disease gene expression data for Testicular Sex Cord-Stromal Tumor.

Pathways for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Pathways related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5S100B, PGR
29.5CEACAM5, MUC1
3
Show member pathways
9.5VIM, DES
4
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.5VIM, DES

Compounds for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Compounds related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1orcein449.5S100B, DES, VIM
2eosin449.4MUC1, S100B, VIM
3gold449.2SYP, DES, MUC1, CEACAM5
4ethanol44 50 24 1112.1SYP, S100B, MUC1, DES
54-hydroxytamoxifen449.0PGR, VIM, S100B
6ganglioside449.0CEACAM5, DES, VIM, SYP
7bezafibrate44 28 1110.9ALPP, VIM, DES
8acetylcholine44 50 28 24 1112.9S100B, SYP, DES, VIM
9gaba448.9PGR, S100B, SYP, VIM
10dihydrotestosterone44 28 24 1111.9DES, PGR, MUC1, VIM
11hyaluronic acid44 249.9MUC1, CEACAM5, VIM, DES
12dbc-amp448.8SYP, VIM, S100B
13norepinephrine44 24 1110.7SYP, DES, ALPP, S100B
14s 100448.7DES, VIM, MUC1, SYP, S100B
15reticulin448.7MUC1, VIM, DES, SYP, S100B
16formaldehyde44 249.7DES, SYP, VIM, MUC1, S100B
17agar448.7CEACAM5, MUC1, VIM, PGR
18procollagen448.7VIM, ALPP, DES
19choline44 24 1110.6SYP, S100B, ALPP, VIM
20steroid448.6S100B, CEACAM5, PGR, DES, SYP
21cyclic amp44 249.6SYP, S100B, MUC1, DES, VIM
22doxorubicin44 50 1110.6DES, CEACAM5, VIM, PGR
23neomycin448.6CEACAM5, VIM, ALPP
24forskolin44 50 1110.5MUC1, VIM, SYP, S100B
25hydroxyapatite448.5S100B, ALPP, CEACAM5, VIM
26chloramphenicol44 2 50 1111.5MUC1, S100B, ALPP, VIM
27adriamycin448.4PGR, DES, CEACAM5, MUC1, VIM
28folate448.4PGR, MUC1, VIM, ALPP
29dmso448.4MUC1, VIM, PGR, ALPP
30butyrate448.3ALPP, VIM, MUC1, CEACAM5
31tamoxifen44 50 28 1111.3VIM, MUC1, ALPP, PGR
32thymidine44 249.3S100B, DES, MUC1, CEACAM5, ALPP
33mucicarmine448.2MUC1, S100B, SYP, VIM, DES, CEACAM5
34hematoxylin448.2VIM, DES, S100B, SYP, CEACAM5, MUC1
35glycogen44 249.2CEACAM5, MUC1, DES, VIM, S100B, SYP
36genistein44 28 61 2 24 1113.2ALPP, PGR, VIM, SYP
37progestin448.1MUC1, VIM, PGR, DES, ALPP
38lactate448.1ALPP, CEACAM5, VIM, DES, S100B
39estradiol44 24 1110.1DES, SYP, CEACAM5, MUC1, VIM, PGR
40creatinine447.8S100B, ALPP, VIM, SYP, MUC1, DES
41serine447.7S100B, MUC1, SYP, VIM, DES, ALPP
42dexamethasone44 50 28 1110.7SYP, ALPP, MUC1, VIM, PGR, S100B
43progesterone44 28 61 24 1111.7CEACAM5, VIM, S100B, DES, SYP, PGR
44b 723447.4SYP, DES, VIM, S100B, ALPP, CEACAM5
45testosterone44 61 24 1110.4SYP, ALPP, MUC1, S100B, VIM, PGR
46retinoic acid44 248.3S100B, SYP, ALPP, MUC1, VIM, PGR
47paraffin446.8DES, PGR, VIM, MUC1, CEACAM5, SYP
48vegf446.8PGR, VIM, MUC1, CEACAM5, SYP, ALPP
49estrogen446.8DES, PGR, ALPP, MUC1, CEACAM5, SYP
50cysteine446.8PGR, DES, S100B, ALPP, SYP, CEACAM5

GO Terms for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Biological processes related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.5VIM, DES
2regulation of neuronal synaptic plasticityGO:0481689.4S100B, SYP

Molecular functions related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428028.2S100B, SYP, CEACAM5, VIM, DES

Products for genes affiliated with Testicular Sex Cord-Stromal Tumor

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  • Antibodies
  • Proteins
  • Lysates

Sources for Testicular Sex Cord-Stromal Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet