MCID: TST037
MIFTS: 33

Testicular Sex Cord-Stromal Tumor malady

Cancer diseases, Rare diseases, Reproductive diseases categories
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Summaries for Testicular Sex Cord-Stromal Tumor

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33MalaCards
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MalaCards: Testicular Sex Cord-Stromal Tumor, also known as sex cord-stromal tumor of the testis, is related to sex cord-gonadal stromal tumor and melanotic neuroectodermal tumor. An important gene associated with Testicular Sex Cord-Stromal Tumor is SYP (synaptophysin), and among its related pathways are Nuclear signaling by ERBB4 and Cell adhesion Cell matrix glycoconjugates. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include testis, and related mouse phenotype normal.

Aliases & Classifications for Testicular Sex Cord-Stromal Tumor

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49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

testicular sex cord-stromal tumor 49
sex cord-stromal tumor of the testis 49


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ICD10 via Orphanet26 C62

Related Diseases for Testicular Sex Cord-Stromal Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Testicular Sex Cord-Stromal Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1sex cord-gonadal stromal tumor30.5VIM, DES, PGR, MUC1, CEACAM5, ALPP
2melanotic neuroectodermal tumor10.1SYP
3infantile myofibromatosis10.1DES
4dysembryoplastic neuroepithelial tumor10.1SYP
5rosai-dorfman disease10.1S100B
6hidradenoma10.1MUC1
7adenomatoid tumor10.1VIM
8papillary ependymoma10.1S100B, SYP
9subependymal giant cell astrocytoma10.1S100B, SYP
10olfactory neuroblastoma10.1SYP, S100B
11syringoma10.1S100B, MUC1
12fibrous meningioma10.1S100B, MUC1
13pineocytoma10.1SYP, S100B
14desmoplastic small round cell tumor10.1DES, MUC1
15cutaneous fibrous histiocytoma10.1S100B, DES
16ganglioneuroblastoma10.1S100B, SYP
17anaplastic ependymoma10.1MUC1, S100B
18cystadenocarcinoma10.1MUC1, CEACAM5
19merkel cell carcinoma10.1MUC1, SYP
20male breast cancer10.1SYP, PGR
21ganglioglioma10.1S100B, SYP
22lung cancer10.1MUC1, SYP
23ganglioneuroma10.1S100B, SYP
24adenosarcoma10.1DES, PGR
25epithelioid leiomyosarcoma10.1VIM, DES
26mammary paget's disease10.1PGR, MUC1
27pseudosarcomatous fibromatosis10.1DES, VIM
28secretory meningioma10.1VIM, MUC1
29lymphangioleiomyomatosis10.1PGR, DES
30sertoli-leydig cell tumor10.0MUC1, PGR
31papillary adenocarcinoma10.0MUC1, CEACAM5
32alveolar soft part sarcoma10.0VIM, DES
33pilocytic astrocytoma10.0S100B, SYP
34clear cell ependymoma10.0VIM, MUC1
35large cell carcinoma10.0SYP, CEACAM5
36fibroma10.0DES, VIM
37myoepithelioma10.0VIM, S100B
38epithelioid sarcoma10.0VIM, MUC1
39choroid plexus papilloma10.0MUC1, SYP, S100B
40malignant mixed mullerian tumor10.0PGR, VIM
41hemangioblastoma10.0S100B, SYP, MUC1
42phyllode tumor10.0VIM, PGR
43cervical adenocarcinoma10.0PGR, CEACAM5
44medulloblastoma10.0SYP, S100B, DES
45paraganglioma10.0S100B, SYP
46malignant pleural mesothelioma10.0CEACAM5, MUC1
47malignant peripheral nerve sheath tumor10.0VIM, S100B
48mucoepidermoid carcinoma10.0MUC1, CEACAM5
49angiosarcoma10.0VIM, MUC1
50glomus tumor10.0DES, VIM, SYP

Graphical network of the top 20 diseases related to Testicular Sex Cord-Stromal Tumor:



Diseases related to testicular sex cord-stromal tumor

Symptoms for Testicular Sex Cord-Stromal Tumor

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Drugs & Therapeutics for Testicular Sex Cord-Stromal Tumor

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Testicular Sex Cord-Stromal Tumor

Search NIH Clinical Center for Testicular Sex Cord-Stromal Tumor

Genetic Tests for Testicular Sex Cord-Stromal Tumor

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Anatomical Context for Testicular Sex Cord-Stromal Tumor

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33MalaCards
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MalaCards organs/tissues related to Testicular Sex Cord-Stromal Tumor:

33
Testis

Animal Models for Testicular Sex Cord-Stromal Tumor or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Testicular Sex Cord-Stromal Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.9S100B, ALPP, SYP, MUC1, PGR

Publications for Testicular Sex Cord-Stromal Tumor

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52PubMed
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Articles related to Testicular Sex Cord-Stromal Tumor:

idTitleAuthorsYear
1
Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. (9591732)
1998
2
Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. (9720507)
1998
3
Testicular sex cord-stromal tumors in children: clinicopathologic study of sixteen children with review of the literature. (9025845)
1996

Variations for Testicular Sex Cord-Stromal Tumor

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Expression for genes affiliated with Testicular Sex Cord-Stromal Tumor

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Testicular Sex Cord-Stromal Tumor

Search GEO for disease gene expression data for Testicular Sex Cord-Stromal Tumor.

Pathways for genes affiliated with Testicular Sex Cord-Stromal Tumor

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50PathCards, 55Reactome, 60Thomson Reuters, 38NCBI BioSystems Database
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Pathways related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5S100B, PGR
29.5CEACAM5, MUC1
3
Show member pathways
9.5VIM, DES
4
Show member pathways
Signaling by Aurora kinases38
Aurora C signaling38
9.5VIM, DES

Compounds for genes affiliated with Testicular Sex Cord-Stromal Tumor

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45Novoseek, 51PharmGKB, 24HMDB, 11DrugBank, 29IUPHAR, 3BitterDB, 61Tocris Bioscience
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Compounds related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1orcein459.5S100B, DES, VIM
2eosin459.4MUC1, S100B, VIM
3gold459.2SYP, DES, MUC1, CEACAM5
4ethanol45 51 24 1112.1SYP, S100B, MUC1, DES
54-hydroxytamoxifen459.0PGR, VIM, S100B
6ganglioside459.0CEACAM5, DES, VIM, SYP
7bezafibrate45 29 1110.9ALPP, VIM, DES
8acetylcholine45 51 29 24 1112.9S100B, SYP, DES, VIM
9gaba458.9PGR, S100B, SYP, VIM
10dihydrotestosterone45 29 24 1111.9DES, PGR, MUC1, VIM
11hyaluronic acid45 249.9MUC1, CEACAM5, VIM, DES
12dbc-amp458.8SYP, VIM, S100B
13norepinephrine45 24 1110.7SYP, DES, ALPP, S100B
14s 100458.7DES, VIM, MUC1, SYP, S100B
15reticulin458.7MUC1, VIM, DES, SYP, S100B
16formaldehyde45 249.7DES, SYP, VIM, MUC1, S100B
17agar458.7CEACAM5, MUC1, VIM, PGR
18procollagen458.7VIM, ALPP, DES
19choline45 24 1110.6SYP, S100B, ALPP, VIM
20steroid458.6S100B, CEACAM5, PGR, DES, SYP
21cyclic amp45 249.6SYP, S100B, MUC1, DES, VIM
22doxorubicin45 51 1110.6DES, CEACAM5, VIM, PGR
23neomycin458.6CEACAM5, VIM, ALPP
24forskolin45 51 1110.5MUC1, VIM, SYP, S100B
25hydroxyapatite458.5S100B, ALPP, CEACAM5, VIM
26chloramphenicol45 3 51 1111.5MUC1, S100B, ALPP, VIM
27adriamycin458.4PGR, DES, CEACAM5, MUC1, VIM
28folate458.4PGR, MUC1, VIM, ALPP
29dmso458.4MUC1, VIM, PGR, ALPP
30butyrate458.3ALPP, VIM, MUC1, CEACAM5
31tamoxifen45 51 29 1111.3VIM, MUC1, ALPP, PGR
32thymidine45 249.3S100B, DES, MUC1, CEACAM5, ALPP
33mucicarmine458.2MUC1, S100B, SYP, VIM, DES, CEACAM5
34hematoxylin458.2VIM, DES, S100B, SYP, CEACAM5, MUC1
35glycogen45 249.2CEACAM5, MUC1, DES, VIM, S100B, SYP
36genistein45 29 61 3 24 1113.2ALPP, PGR, VIM, SYP
37progestin458.1MUC1, VIM, PGR, DES, ALPP
38lactate458.1ALPP, CEACAM5, VIM, DES, S100B
39estradiol45 24 1110.1DES, SYP, CEACAM5, MUC1, VIM, PGR
40creatinine457.8S100B, ALPP, VIM, SYP, MUC1, DES
41serine457.7S100B, MUC1, SYP, VIM, DES, ALPP
42dexamethasone45 51 29 1110.7SYP, ALPP, MUC1, VIM, PGR, S100B
43progesterone45 29 61 24 1111.7CEACAM5, VIM, S100B, DES, SYP, PGR
44b 723457.4SYP, DES, VIM, S100B, ALPP, CEACAM5
45testosterone45 61 24 1110.4SYP, ALPP, MUC1, S100B, VIM, PGR
46retinoic acid45 248.3S100B, SYP, ALPP, MUC1, VIM, PGR
47paraffin456.8DES, PGR, VIM, MUC1, CEACAM5, SYP
48vegf456.8PGR, VIM, MUC1, CEACAM5, SYP, ALPP
49estrogen456.8DES, PGR, ALPP, MUC1, CEACAM5, SYP
50cysteine456.8PGR, DES, S100B, ALPP, SYP, CEACAM5

GO Terms for genes affiliated with Testicular Sex Cord-Stromal Tumor

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16Gene Ontology
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Biological processes related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.5VIM, DES
2regulation of neuronal synaptic plasticityGO:0481689.4S100B, SYP

Molecular functions related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428028.2S100B, SYP, CEACAM5, VIM, DES

Products for genes affiliated with Testicular Sex Cord-Stromal Tumor

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  • Antibodies
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Sources for Testicular Sex Cord-Stromal Tumor

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet