MCID: TST037
MIFTS: 33

Testicular Sex Cord-Stromal Tumor malady

Cancer diseases, Rare diseases, Reproductive diseases categories

Summaries for Testicular Sex Cord-Stromal Tumor

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34MalaCards
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MalaCards: Testicular Sex Cord-Stromal Tumor, also known as sex cord-stromal tumor of the testis, is related to sex cord-gonadal stromal tumor and melanotic neuroectodermal tumor. An important gene associated with Testicular Sex Cord-Stromal Tumor is SYP (synaptophysin), and among its related pathways are Nuclear signaling by ERBB4 and Cell adhesion Cell matrix glycoconjugates. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include testis, and related mouse phenotype normal.

Aliases & Classifications for Testicular Sex Cord-Stromal Tumor

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50Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

testicular sex cord-stromal tumor 50
sex cord-stromal tumor of the testis 50


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ICD10 via Orphanet27 C62

Related Diseases for Testicular Sex Cord-Stromal Tumor

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18GeneCards, 19GeneDecks
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Diseases related to Testicular Sex Cord-Stromal Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1sex cord-gonadal stromal tumor30.5VIM, DES, PGR, MUC1, CEACAM5, ALPP
2melanotic neuroectodermal tumor10.1SYP
3infantile myofibromatosis10.1DES
4dysembryoplastic neuroepithelial tumor10.1SYP
5rosai-dorfman disease10.1S100B
6hidradenoma10.1MUC1
7adenomatoid tumor10.1VIM
8papillary ependymoma10.1S100B, SYP
9subependymal giant cell astrocytoma10.1S100B, SYP
10olfactory neuroblastoma10.1SYP, S100B
11syringoma10.1S100B, MUC1
12fibrous meningioma10.1S100B, MUC1
13pineocytoma10.1SYP, S100B
14desmoplastic small round cell tumor10.1DES, MUC1
15cutaneous fibrous histiocytoma10.1S100B, DES
16ganglioneuroblastoma10.1S100B, SYP
17anaplastic ependymoma10.1MUC1, S100B
18cystadenocarcinoma10.1MUC1, CEACAM5
19merkel cell carcinoma10.1MUC1, SYP
20male breast cancer10.1SYP, PGR
21ganglioglioma10.1S100B, SYP
22lung cancer10.1MUC1, SYP
23ganglioneuroma10.1S100B, SYP
24adenosarcoma10.1DES, PGR
25epithelioid leiomyosarcoma10.1VIM, DES
26mammary paget's disease10.1PGR, MUC1
27pseudosarcomatous fibromatosis10.1DES, VIM
28secretory meningioma10.1VIM, MUC1
29lymphangioleiomyomatosis10.1PGR, DES
30sertoli-leydig cell tumor10.0MUC1, PGR
31papillary adenocarcinoma10.0MUC1, CEACAM5
32alveolar soft part sarcoma10.0VIM, DES
33pilocytic astrocytoma10.0S100B, SYP
34clear cell ependymoma10.0VIM, MUC1
35large cell carcinoma10.0SYP, CEACAM5
36fibroma10.0DES, VIM
37myoepithelioma10.0VIM, S100B
38epithelioid sarcoma10.0VIM, MUC1
39choroid plexus papilloma10.0MUC1, SYP, S100B
40malignant mixed mullerian tumor10.0PGR, VIM
41hemangioblastoma10.0S100B, SYP, MUC1
42phyllode tumor10.0VIM, PGR
43cervical adenocarcinoma10.0PGR, CEACAM5
44medulloblastoma10.0SYP, S100B, DES
45paraganglioma10.0S100B, SYP
46malignant pleural mesothelioma10.0CEACAM5, MUC1
47malignant peripheral nerve sheath tumor10.0VIM, S100B
48mucoepidermoid carcinoma10.0MUC1, CEACAM5
49angiosarcoma10.0VIM, MUC1
50glomus tumor10.0DES, VIM, SYP

Graphical network of the top 20 diseases related to Testicular Sex Cord-Stromal Tumor:



Diseases related to testicular sex cord-stromal tumor

Symptoms for Testicular Sex Cord-Stromal Tumor

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Drugs & Therapeutics for Testicular Sex Cord-Stromal Tumor

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Testicular Sex Cord-Stromal Tumor

Genetic Tests for Testicular Sex Cord-Stromal Tumor

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Anatomical Context for Testicular Sex Cord-Stromal Tumor

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34MalaCards
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MalaCards organs/tissues related to Testicular Sex Cord-Stromal Tumor:

34
Testis

Animal Models for Testicular Sex Cord-Stromal Tumor or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Testicular Sex Cord-Stromal Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.9S100B, ALPP, SYP, MUC1, PGR

Publications for Testicular Sex Cord-Stromal Tumor

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53PubMed
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Articles related to Testicular Sex Cord-Stromal Tumor:

idTitleAuthorsYear
1
Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. (9591732)
1998
2
Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. (9720507)
1998
3
Testicular sex cord-stromal tumors in children: clinicopathologic study of sixteen children with review of the literature. (9025845)
1996

Variations for Testicular Sex Cord-Stromal Tumor

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Expression for genes affiliated with Testicular Sex Cord-Stromal Tumor

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Testicular Sex Cord-Stromal Tumor

Search GEO for disease gene expression data for Testicular Sex Cord-Stromal Tumor.

Pathways for genes affiliated with Testicular Sex Cord-Stromal Tumor

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51PathCards, 56Reactome, 61Thomson Reuters, 39NCBI BioSystems Database
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Pathways related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5S100B, PGR
29.5CEACAM5, MUC1
3
Show member pathways
9.5VIM, DES
4
Show member pathways
Signaling by Aurora kinases39
Aurora C signaling39
9.5VIM, DES

Compounds for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Sources:
46Novoseek, 52PharmGKB, 25HMDB, 12DrugBank, 30IUPHAR, 3BitterDB, 62Tocris Bioscience
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Compounds related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1orcein469.5S100B, DES, VIM
2eosin469.4MUC1, S100B, VIM
3gold469.2SYP, DES, MUC1, CEACAM5
4ethanol46 52 25 1212.1SYP, S100B, MUC1, DES
54-hydroxytamoxifen469.0PGR, VIM, S100B
6ganglioside469.0CEACAM5, DES, VIM, SYP
7bezafibrate46 30 1210.9ALPP, VIM, DES
8acetylcholine46 52 30 25 1212.9S100B, SYP, DES, VIM
9gaba468.9PGR, S100B, SYP, VIM
10dihydrotestosterone46 30 25 1211.9DES, PGR, MUC1, VIM
11hyaluronic acid46 259.9MUC1, CEACAM5, VIM, DES
12dbc-amp468.8SYP, VIM, S100B
13norepinephrine46 25 1210.7SYP, DES, ALPP, S100B
14s 100468.7DES, VIM, MUC1, SYP, S100B
15reticulin468.7MUC1, VIM, DES, SYP, S100B
16formaldehyde46 259.7DES, SYP, VIM, MUC1, S100B
17agar468.7CEACAM5, MUC1, VIM, PGR
18procollagen468.7VIM, ALPP, DES
19choline46 25 1210.6SYP, S100B, ALPP, VIM
20steroid468.6S100B, CEACAM5, PGR, DES, SYP
21cyclic amp46 259.6SYP, S100B, MUC1, DES, VIM
22doxorubicin46 52 1210.6DES, CEACAM5, VIM, PGR
23neomycin468.6CEACAM5, VIM, ALPP
24forskolin46 52 1210.5MUC1, VIM, SYP, S100B
25hydroxyapatite468.5S100B, ALPP, CEACAM5, VIM
26chloramphenicol46 3 52 1211.5MUC1, S100B, ALPP, VIM
27adriamycin468.4PGR, DES, CEACAM5, MUC1, VIM
28folate468.4PGR, MUC1, VIM, ALPP
29dmso468.4MUC1, VIM, PGR, ALPP
30butyrate468.3ALPP, VIM, MUC1, CEACAM5
31tamoxifen46 52 30 1211.3VIM, MUC1, ALPP, PGR
32thymidine46 259.3S100B, DES, MUC1, CEACAM5, ALPP
33mucicarmine468.2MUC1, S100B, SYP, VIM, DES, CEACAM5
34hematoxylin468.2VIM, DES, S100B, SYP, CEACAM5, MUC1
35glycogen46 259.2CEACAM5, MUC1, DES, VIM, S100B, SYP
36genistein46 30 62 3 25 1213.2ALPP, PGR, VIM, SYP
37progestin468.1MUC1, VIM, PGR, DES, ALPP
38lactate468.1ALPP, CEACAM5, VIM, DES, S100B
39estradiol46 25 1210.1DES, SYP, CEACAM5, MUC1, VIM, PGR
40creatinine467.8S100B, ALPP, VIM, SYP, MUC1, DES
41serine467.7S100B, MUC1, SYP, VIM, DES, ALPP
42dexamethasone46 52 30 1210.7SYP, ALPP, MUC1, VIM, PGR, S100B
43progesterone46 30 62 25 1211.7CEACAM5, VIM, S100B, DES, SYP, PGR
44b 723467.4SYP, DES, VIM, S100B, ALPP, CEACAM5
45testosterone46 62 25 1210.4SYP, ALPP, MUC1, S100B, VIM, PGR
46retinoic acid46 258.3S100B, SYP, ALPP, MUC1, VIM, PGR
47paraffin466.8DES, PGR, VIM, MUC1, CEACAM5, SYP
48vegf466.8PGR, VIM, MUC1, CEACAM5, SYP, ALPP
49estrogen466.8DES, PGR, ALPP, MUC1, CEACAM5, SYP
50cysteine466.8PGR, DES, S100B, ALPP, SYP, CEACAM5

GO Terms for genes affiliated with Testicular Sex Cord-Stromal Tumor

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17Gene Ontology
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Biological processes related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.5VIM, DES
2regulation of neuronal synaptic plasticityGO:0481689.4S100B, SYP

Molecular functions related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428028.2S100B, SYP, CEACAM5, VIM, DES

Products for genes affiliated with Testicular Sex Cord-Stromal Tumor

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  • Antibodies
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Sources for Testicular Sex Cord-Stromal Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet