MCID: TST037
MIFTS: 30

Testicular Sex Cord-Stromal Tumor malady

Cancer diseases, Rare diseases, Reproductive diseases categories

Summaries for Testicular Sex Cord-Stromal Tumor

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MalaCards based summary: Testicular Sex Cord-Stromal Tumor, also known as sex cord-stromal tumor of the testis, is related to sex cord-gonadal stromal tumor and melanotic neuroectodermal tumor. An important gene associated with Testicular Sex Cord-Stromal Tumor is SYP (synaptophysin), and among its related pathways are Nuclear signaling by ERBB4 and Cell adhesion Cell matrix glycoconjugates. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include testis, and related mouse phenotype normal.

Aliases & Classifications for Testicular Sex Cord-Stromal Tumor

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Sources:
47Orphanet, 60UMLS, 26ICD10 via Orphanet
See all sources

Testicular Sex Cord-Stromal Tumor, Aliases & Descriptions:

Name: Testicular Sex Cord-Stromal Tumor 47 60
 
Sex Cord-Stromal Tumor of the Testis 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

47
testicular sex cord-stromal tumor:
Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe)


External Ids:

Orphanet47 363489
ICD10 via Orphanet26 C62

Related Diseases for Testicular Sex Cord-Stromal Tumor

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Diseases related to Testicular Sex Cord-Stromal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1sex cord-gonadal stromal tumor29.5S100B, DES, PGR, VIM, MUC1, CEACAM5
2melanotic neuroectodermal tumor10.5SYP
3infantile myofibromatosis10.5DES
4dysembryoplastic neuroepithelial tumor10.5SYP
5hidradenoma10.4MUC1
6rosai-dorfman disease10.4S100B
7adenomatoid tumor10.4VIM
82q37 deletion syndrome10.4
9papillary ependymoma10.3SYP, S100B
10subependymal giant cell astrocytoma10.3SYP, S100B
11olfactory neuroblastoma10.3SYP, S100B
12syringoma10.3MUC1, S100B
13fibrous meningioma10.3MUC1, S100B
14pineocytoma10.3SYP, S100B
15desmoplastic small round cell tumor10.3MUC1, DES
16cutaneous fibrous histiocytoma10.3DES, S100B
17ganglioneuroblastoma10.3SYP, S100B
18anaplastic ependymoma10.3MUC1, S100B
19cystadenocarcinoma10.3MUC1, CEACAM5
20merkel cell carcinoma10.3MUC1, SYP
21ganglioglioma10.3S100B, SYP
22breast cancer10.3PGR, SYP
23lung cancer10.2MUC1, SYP
24adenosarcoma10.2DES, PGR
25ganglioneuroma10.2S100B, SYP
26epithelioid leiomyosarcoma10.2DES, VIM
27mammary paget's disease10.2PGR, MUC1
28pseudosarcomatous fibromatosis10.2VIM, DES
29lymphangioleiomyomatosis10.2DES, PGR
30secretory meningioma10.2VIM, MUC1
31sertoli-leydig cell tumor10.2PGR, MUC1
32papillary adenocarcinoma10.2MUC1, CEACAM5
33alveolar soft-part sarcoma10.2DES, VIM
34pilocytic astrocytoma10.2S100B, SYP
35clear cell ependymoma10.2VIM, MUC1
36myoepithelioma10.2VIM, S100B
37fibroma10.2DES, VIM
38large cell carcinoma10.2CEACAM5, SYP
39epithelioid sarcoma10.2VIM, MUC1
40choroid plexus papilloma10.1S100B, SYP, MUC1
41malignant mixed mullerian tumor10.1PGR, VIM
42hemangioblastoma10.1MUC1, SYP, S100B
43benign breast phyllodes tumor10.1PGR, VIM
44malignant pleural mesothelioma10.1CEACAM5, MUC1
45cervical adenocarcinoma10.1CEACAM5, PGR
46medulloblastoma10.1DES, SYP, S100B
47paraganglioma10.1S100B, SYP
48malignant peripheral nerve sheath tumor10.1VIM, S100B
49mucoepidermoid carcinoma10.1MUC1, CEACAM5
50angiosarcoma10.1MUC1, VIM

Graphical network of the top 20 diseases related to Testicular Sex Cord-Stromal Tumor:



Diseases related to testicular sex cord-stromal tumor

Symptoms for Testicular Sex Cord-Stromal Tumor

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Drugs & Therapeutics for Testicular Sex Cord-Stromal Tumor

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Drug clinical trials:

Search ClinicalTrials for Testicular Sex Cord-Stromal Tumor

Search NIH Clinical Center for Testicular Sex Cord-Stromal Tumor

Genetic Tests for Testicular Sex Cord-Stromal Tumor

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Anatomical Context for Testicular Sex Cord-Stromal Tumor

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MalaCards organs/tissues related to Testicular Sex Cord-Stromal Tumor:

31
Testis

Animal Models for Testicular Sex Cord-Stromal Tumor or affiliated genes

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MGI Mouse Phenotypes related to Testicular Sex Cord-Stromal Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.9S100B, ALPP, SYP, MUC1, PGR

Publications for Testicular Sex Cord-Stromal Tumor

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Articles related to Testicular Sex Cord-Stromal Tumor:

idTitleAuthorsYear
1
Testicular sex cord-stromal tumor in a boy with 2q37 deletion syndrome. (24755370)
2014
2
Biphasic malignant testicular sex cord-stromal tumor in a cotton-top tamarin (Saguinus oedipus) with review of the literature. (18984797)
2008
3
Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. (9591732)
1998
4
Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. (9720507)
1998
5
Testicular sex cord-stromal tumors in children: clinicopathologic study of sixteen children with review of the literature. (9025845)
1996

Variations for Testicular Sex Cord-Stromal Tumor

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Expression for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Search GEO for disease gene expression data for Testicular Sex Cord-Stromal Tumor.

Pathways for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Pathways related to Testicular Sex Cord-Stromal Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5S100B, PGR
29.5CEACAM5, MUC1
3
Show member pathways
9.5VIM, DES
4
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.5VIM, DES

Compounds for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Compounds related to Testicular Sex Cord-Stromal Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1orcein439.5S100B, DES, VIM
2eosin439.4MUC1, S100B, VIM
3gold439.2SYP, DES, MUC1, CEACAM5
4ethanol43 49 24 1212.1SYP, S100B, MUC1, DES
54-hydroxytamoxifen439.0PGR, VIM, S100B
6ganglioside439.0CEACAM5, DES, VIM, SYP
7bezafibrate43 28 1210.9ALPP, VIM, DES
8acetylcholine43 49 28 24 1212.9S100B, SYP, DES, VIM
9gaba438.9PGR, S100B, SYP, VIM
10dihydrotestosterone43 28 24 1211.9DES, PGR, MUC1, VIM
11hyaluronic acid43 249.9MUC1, CEACAM5, VIM, DES
12dbc-amp438.8SYP, VIM, S100B
13norepinephrine43 24 1210.7SYP, DES, ALPP, S100B
14s 100438.7DES, VIM, MUC1, SYP, S100B
15reticulin438.7MUC1, VIM, DES, SYP, S100B
16formaldehyde43 249.7DES, SYP, VIM, MUC1, S100B
17agar438.7CEACAM5, MUC1, VIM, PGR
18procollagen438.7VIM, ALPP, DES
19choline43 24 1210.6SYP, S100B, ALPP, VIM
20steroid438.6S100B, CEACAM5, PGR, DES, SYP
21cyclic amp43 249.6SYP, S100B, MUC1, DES, VIM
22doxorubicin43 49 1210.6DES, CEACAM5, VIM, PGR
23neomycin438.6CEACAM5, VIM, ALPP
24forskolin43 49 1210.5MUC1, VIM, SYP, S100B
25hydroxyapatite438.5S100B, ALPP, CEACAM5, VIM
26chloramphenicol43 2 49 1211.5MUC1, S100B, ALPP, VIM
27adriamycin438.4PGR, DES, CEACAM5, MUC1, VIM
28folate438.4PGR, MUC1, VIM, ALPP
29dmso438.4MUC1, VIM, PGR, ALPP
30butyrate438.3ALPP, VIM, MUC1, CEACAM5
31tamoxifen43 49 28 1211.3VIM, MUC1, ALPP, PGR
32thymidine43 249.3S100B, DES, MUC1, CEACAM5, ALPP
33mucicarmine438.2MUC1, S100B, SYP, VIM, DES, CEACAM5
34hematoxylin438.2VIM, DES, S100B, SYP, CEACAM5, MUC1
35glycogen43 249.2CEACAM5, MUC1, DES, VIM, S100B, SYP
36genistein43 28 59 2 24 1213.2ALPP, PGR, VIM, SYP
37progestin438.1MUC1, VIM, PGR, DES, ALPP
38lactate438.1ALPP, CEACAM5, VIM, DES, S100B
39estradiol43 24 1210.1DES, SYP, CEACAM5, MUC1, VIM, PGR
40creatinine437.8S100B, ALPP, VIM, SYP, MUC1, DES
41serine437.7S100B, MUC1, SYP, VIM, DES, ALPP
42dexamethasone43 49 28 1210.7SYP, ALPP, MUC1, VIM, PGR, S100B
43progesterone43 28 59 24 1211.7CEACAM5, VIM, S100B, DES, SYP, PGR
44b 723437.4SYP, DES, VIM, S100B, ALPP, CEACAM5
45testosterone43 59 24 1210.4SYP, ALPP, MUC1, S100B, VIM, PGR
46retinoic acid43 248.3S100B, SYP, ALPP, MUC1, VIM, PGR
47paraffin436.8DES, PGR, VIM, MUC1, CEACAM5, SYP
48vegf436.8PGR, VIM, MUC1, CEACAM5, SYP, ALPP
49estrogen436.8DES, PGR, ALPP, MUC1, CEACAM5, SYP
50cysteine436.8PGR, DES, S100B, ALPP, SYP, CEACAM5

GO Terms for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Biological processes related to Testicular Sex Cord-Stromal Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.5VIM, DES
2regulation of neuronal synaptic plasticityGO:00481689.4S100B, SYP

Molecular functions related to Testicular Sex Cord-Stromal Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:00428028.2S100B, SYP, CEACAM5, VIM, DES

Products for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Sources for Testicular Sex Cord-Stromal Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet