MCID: TST037
MIFTS: 35

Testicular Sex Cord-Stromal Tumor malady

Cancer diseases, Rare diseases, Reproductive diseases categories

Summaries for Testicular Sex Cord-Stromal Tumor

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MalaCards based summary: Testicular Sex Cord-Stromal Tumor, also known as sex cord-stromal tumor of the testis, is related to sex cord-gonadal stromal tumor and 2q37 deletion syndrome. An important gene associated with Testicular Sex Cord-Stromal Tumor is SYP (synaptophysin), and among its related pathways are Nuclear signaling by ERBB4 and Cell adhesion Cell matrix glycoconjugates. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include testis, and related mouse phenotype normal.

Aliases & Classifications for Testicular Sex Cord-Stromal Tumor

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Sources:
49Orphanet, 62UMLS, 28ICD10 via Orphanet
See all sources

Testicular Sex Cord-Stromal Tumor, Aliases & Descriptions:

Name: Testicular Sex Cord-Stromal Tumor 49 62
 
Sex Cord-Stromal Tumor of the Testis 49 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

49
sex cord-stromal tumor of the testis:
Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe)


External Ids:

Orphanet49 363489
ICD10 via Orphanet28 C62

Related Diseases for Testicular Sex Cord-Stromal Tumor

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Diseases related to Testicular Sex Cord-Stromal Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1sex cord-gonadal stromal tumor30.6VIM, DES, PGR, MUC1, CEACAM5, ALPP
22q37 deletion syndrome10.4
3melanotic neuroectodermal tumor10.1SYP
4infantile myofibromatosis10.1DES
5dysembryoplastic neuroepithelial tumor10.1SYP
6rosai-dorfman disease10.1S100B
7hidradenoma10.1MUC1
8adenomatoid tumor10.0VIM
9papillary ependymoma10.0S100B, SYP
10subependymal giant cell astrocytoma10.0S100B, SYP
11olfactory neuroblastoma10.0SYP, S100B
12syringoma10.0S100B, MUC1
13fibrous meningioma10.0S100B, MUC1
14pineocytoma10.0SYP, S100B
15desmoplastic small round cell tumor10.0DES, MUC1
16cutaneous fibrous histiocytoma10.0S100B, DES
17ganglioneuroblastoma10.0S100B, SYP
18anaplastic ependymoma10.0MUC1, S100B
19cystadenocarcinoma10.0MUC1, CEACAM5
20merkel cell carcinoma10.0MUC1, SYP
21breast cancer10.0SYP, PGR
22ganglioglioma10.0S100B, SYP
23lung cancer10.0MUC1, SYP
24ganglioneuroma10.0S100B, SYP
25adenosarcoma10.0DES, PGR
26epithelioid leiomyosarcoma10.0VIM, DES
27mammary paget's disease10.0PGR, MUC1
28pseudosarcomatous fibromatosis10.0DES, VIM
29secretory meningioma10.0VIM, MUC1
30lymphangioleiomyomatosis10.0PGR, DES
31sertoli-leydig cell tumor10.0MUC1, PGR
32papillary adenocarcinoma10.0MUC1, CEACAM5
33alveolar soft-part sarcoma10.0VIM, DES
34pilocytic astrocytoma10.0S100B, SYP
35clear cell ependymoma10.0VIM, MUC1
36large cell carcinoma10.0SYP, CEACAM5
37fibroma10.0DES, VIM
38myoepithelioma10.0VIM, S100B
39epithelioid sarcoma10.0VIM, MUC1
40choroid plexus papilloma10.0MUC1, SYP, S100B
41malignant mixed mullerian tumor10.0PGR, VIM
42hemangioblastoma10.0S100B, SYP, MUC1
43phyllode tumor10.0VIM, PGR
44cervical adenocarcinoma10.0PGR, CEACAM5
45medulloblastoma10.0SYP, S100B, DES
46paraganglioma10.0S100B, SYP
47malignant pleural mesothelioma10.0CEACAM5, MUC1
48malignant peripheral nerve sheath tumor10.0VIM, S100B
49mucoepidermoid carcinoma10.0MUC1, CEACAM5
50angiosarcoma10.0VIM, MUC1

Graphical network of the top 20 diseases related to Testicular Sex Cord-Stromal Tumor:



Diseases related to testicular sex cord-stromal tumor

Symptoms for Testicular Sex Cord-Stromal Tumor

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Drugs & Therapeutics for Testicular Sex Cord-Stromal Tumor

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Drug clinical trials:

Search ClinicalTrials for Testicular Sex Cord-Stromal Tumor

Search NIH Clinical Center for Testicular Sex Cord-Stromal Tumor

Genetic Tests for Testicular Sex Cord-Stromal Tumor

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Anatomical Context for Testicular Sex Cord-Stromal Tumor

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MalaCards organs/tissues related to Testicular Sex Cord-Stromal Tumor:

33
Testis

Animal Models for Testicular Sex Cord-Stromal Tumor or affiliated genes

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MGI Mouse Phenotypes related to Testicular Sex Cord-Stromal Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.9S100B, ALPP, SYP, MUC1, PGR

Publications for Testicular Sex Cord-Stromal Tumor

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Articles related to Testicular Sex Cord-Stromal Tumor:

idTitleAuthorsYear
1
Testicular sex cord-stromal tumor in a boy with 2q37 deletion syndrome. (24755370)
2014
2
Biphasic malignant testicular sex cord-stromal tumor in a cotton-top tamarin (Saguinus oedipus) with review of the literature. (18984797)
2008
3
Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. (9591732)
1998
4
Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. (9720507)
1998
5
Testicular sex cord-stromal tumors in children: clinicopathologic study of sixteen children with review of the literature. (9025845)
1996

Variations for Testicular Sex Cord-Stromal Tumor

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Expression for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Search GEO for disease gene expression data for Testicular Sex Cord-Stromal Tumor.

Pathways for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Pathways related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5S100B, PGR
29.5CEACAM5, MUC1
3
Show member pathways
9.5VIM, DES
4
Show member pathways
Signaling by Aurora kinases38
Aurora C signaling38
9.5VIM, DES

Compounds for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Compounds related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1orcein459.5S100B, DES, VIM
2eosin459.4MUC1, S100B, VIM
3gold459.2SYP, DES, MUC1, CEACAM5
4ethanol45 51 26 1312.1SYP, S100B, MUC1, DES
54-hydroxytamoxifen459.0PGR, VIM, S100B
6ganglioside459.0CEACAM5, DES, VIM, SYP
7bezafibrate45 30 1310.9ALPP, VIM, DES
8acetylcholine45 51 30 26 1312.9S100B, SYP, DES, VIM
9gaba458.9PGR, S100B, SYP, VIM
10dihydrotestosterone45 30 26 1311.9DES, PGR, MUC1, VIM
11hyaluronic acid45 269.9MUC1, CEACAM5, VIM, DES
12dbc-amp458.8SYP, VIM, S100B
13norepinephrine45 26 1310.7SYP, DES, ALPP, S100B
14s 100458.7DES, VIM, MUC1, SYP, S100B
15reticulin458.7MUC1, VIM, DES, SYP, S100B
16formaldehyde45 269.7DES, SYP, VIM, MUC1, S100B
17agar458.7CEACAM5, MUC1, VIM, PGR
18procollagen458.7VIM, ALPP, DES
19choline45 26 1310.6SYP, S100B, ALPP, VIM
20steroid458.6S100B, CEACAM5, PGR, DES, SYP
21cyclic amp45 269.6SYP, S100B, MUC1, DES, VIM
22doxorubicin45 51 1310.6DES, CEACAM5, VIM, PGR
23neomycin458.6CEACAM5, VIM, ALPP
24forskolin45 51 1310.5MUC1, VIM, SYP, S100B
25hydroxyapatite458.5S100B, ALPP, CEACAM5, VIM
26chloramphenicol45 3 51 1311.5MUC1, S100B, ALPP, VIM
27adriamycin458.4PGR, DES, CEACAM5, MUC1, VIM
28folate458.4PGR, MUC1, VIM, ALPP
29dmso458.4MUC1, VIM, PGR, ALPP
30butyrate458.3ALPP, VIM, MUC1, CEACAM5
31tamoxifen45 51 30 1311.3VIM, MUC1, ALPP, PGR
32thymidine45 269.3S100B, DES, MUC1, CEACAM5, ALPP
33mucicarmine458.2MUC1, S100B, SYP, VIM, DES, CEACAM5
34hematoxylin458.2VIM, DES, S100B, SYP, CEACAM5, MUC1
35glycogen45 269.2CEACAM5, MUC1, DES, VIM, S100B, SYP
36genistein45 30 61 3 26 1313.2ALPP, PGR, VIM, SYP
37progestin458.1MUC1, VIM, PGR, DES, ALPP
38lactate458.1ALPP, CEACAM5, VIM, DES, S100B
39estradiol45 26 1310.1DES, SYP, CEACAM5, MUC1, VIM, PGR
40creatinine457.8S100B, ALPP, VIM, SYP, MUC1, DES
41serine457.7S100B, MUC1, SYP, VIM, DES, ALPP
42dexamethasone45 51 30 1310.7SYP, ALPP, MUC1, VIM, PGR, S100B
43progesterone45 30 61 26 1311.7CEACAM5, VIM, S100B, DES, SYP, PGR
44b 723457.4SYP, DES, VIM, S100B, ALPP, CEACAM5
45testosterone45 61 26 1310.4SYP, ALPP, MUC1, S100B, VIM, PGR
46retinoic acid45 268.3S100B, SYP, ALPP, MUC1, VIM, PGR
47paraffin456.8DES, PGR, VIM, MUC1, CEACAM5, SYP
48vegf456.8PGR, VIM, MUC1, CEACAM5, SYP, ALPP
49estrogen456.8DES, PGR, ALPP, MUC1, CEACAM5, SYP
50cysteine456.8PGR, DES, S100B, ALPP, SYP, CEACAM5

GO Terms for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Biological processes related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.5VIM, DES
2regulation of neuronal synaptic plasticityGO:00481689.4S100B, SYP

Molecular functions related to Testicular Sex Cord-Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:00428028.2S100B, SYP, CEACAM5, VIM, DES

Products for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Sources for Testicular Sex Cord-Stromal Tumor

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet