MCID: TST037
MIFTS: 30

Testicular Sex Cord-Stromal Tumor malady

Cancer diseases, Rare diseases, Reproductive diseases categories

Aliases & Classifications for Testicular Sex Cord-Stromal Tumor

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Sources:
48Orphanet, 61UMLS, 26ICD10 via Orphanet
See all sources

Aliases & Descriptions for Testicular Sex Cord-Stromal Tumor:

Name: Testicular Sex Cord-Stromal Tumor 48 61
 
Sex Cord-Stromal Tumor of the Testis 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
testicular sex cord-stromal tumor:
Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe)


External Ids:

Orphanet48 363489
ICD10 via Orphanet26 C62

Summaries for Testicular Sex Cord-Stromal Tumor

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MalaCards based summary: Testicular Sex Cord-Stromal Tumor, also known as sex cord-stromal tumor of the testis, is related to sex cord-gonadal stromal tumor and melanotic neuroectodermal tumor. An important gene associated with Testicular Sex Cord-Stromal Tumor is SYP (synaptophysin), and among its related pathways are Nuclear signaling by ERBB4 and Cell adhesion Cell matrix glycoconjugates. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include testis, and related mouse phenotype normal.

Related Diseases for Testicular Sex Cord-Stromal Tumor

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Diseases related to Testicular Sex Cord-Stromal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1sex cord-gonadal stromal tumor29.5S100B, DES, PGR, VIM, MUC1, CEACAM5
2melanotic neuroectodermal tumor10.5SYP
3infantile myofibromatosis10.5DES
4dysembryoplastic neuroepithelial tumor10.5SYP
5hidradenoma10.4MUC1
6rosai-dorfman disease10.4S100B
7adenomatoid tumor10.4VIM
82q37 deletion syndrome10.4
9papillary ependymoma10.3SYP, S100B
10subependymal giant cell astrocytoma10.3SYP, S100B
11olfactory neuroblastoma10.3SYP, S100B
12syringoma10.3MUC1, S100B
13fibrous meningioma10.3MUC1, S100B
14pineocytoma10.3SYP, S100B
15desmoplastic small round cell tumor10.3MUC1, DES
16cutaneous fibrous histiocytoma10.3DES, S100B
17ganglioneuroblastoma10.3SYP, S100B
18anaplastic ependymoma10.3MUC1, S100B
19cystadenocarcinoma10.3MUC1, CEACAM5
20merkel cell carcinoma10.3MUC1, SYP
21ganglioglioma10.3S100B, SYP
22breast cancer10.3PGR, SYP
23lung cancer10.2MUC1, SYP
24adenosarcoma10.2DES, PGR
25ganglioneuroma10.2S100B, SYP
26epithelioid leiomyosarcoma10.2DES, VIM
27mammary paget's disease10.2PGR, MUC1
28pseudosarcomatous fibromatosis10.2VIM, DES
29lymphangioleiomyomatosis10.2DES, PGR
30secretory meningioma10.2VIM, MUC1
31sertoli-leydig cell tumor10.2PGR, MUC1
32papillary adenocarcinoma10.2MUC1, CEACAM5
33alveolar soft-part sarcoma10.2DES, VIM
34pilocytic astrocytoma10.2S100B, SYP
35clear cell ependymoma10.2VIM, MUC1
36myoepithelioma10.2VIM, S100B
37fibroma10.2DES, VIM
38large cell carcinoma10.2CEACAM5, SYP
39epithelioid sarcoma10.2VIM, MUC1
40choroid plexus papilloma10.1S100B, SYP, MUC1
41malignant mixed mullerian tumor10.1PGR, VIM
42hemangioblastoma10.1MUC1, SYP, S100B
43benign breast phyllodes tumor10.1PGR, VIM
44malignant pleural mesothelioma10.1CEACAM5, MUC1
45cervical adenocarcinoma10.1CEACAM5, PGR
46medulloblastoma10.1DES, SYP, S100B
47paraganglioma10.1S100B, SYP
48malignant peripheral nerve sheath tumor10.1VIM, S100B
49mucoepidermoid carcinoma10.1MUC1, CEACAM5
50angiosarcoma10.1MUC1, VIM

Graphical network of the top 20 diseases related to Testicular Sex Cord-Stromal Tumor:



Diseases related to testicular sex cord-stromal tumor

Symptoms for Testicular Sex Cord-Stromal Tumor

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Drugs & Therapeutics for Testicular Sex Cord-Stromal Tumor

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Drug clinical trials:

Search ClinicalTrials for Testicular Sex Cord-Stromal Tumor

Search NIH Clinical Center for Testicular Sex Cord-Stromal Tumor

Genetic Tests for Testicular Sex Cord-Stromal Tumor

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Anatomical Context for Testicular Sex Cord-Stromal Tumor

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MalaCards organs/tissues related to Testicular Sex Cord-Stromal Tumor:

31
Testis

Animal Models for Testicular Sex Cord-Stromal Tumor or affiliated genes

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MGI Mouse Phenotypes related to Testicular Sex Cord-Stromal Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.9S100B, ALPP, SYP, MUC1, PGR

Publications for Testicular Sex Cord-Stromal Tumor

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Articles related to Testicular Sex Cord-Stromal Tumor:

idTitleAuthorsYear
1
Testicular sex cord-stromal tumor in a boy with 2q37 deletion syndrome. (24755370)
2014
2
Biphasic malignant testicular sex cord-stromal tumor in a cotton-top tamarin (Saguinus oedipus) with review of the literature. (18984797)
2008
3
Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. (9591732)
1998
4
Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. (9720507)
1998
5
Testicular sex cord-stromal tumors in children: clinicopathologic study of sixteen children with review of the literature. (9025845)
1996

Variations for Testicular Sex Cord-Stromal Tumor

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Expression for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Search GEO for disease gene expression data for Testicular Sex Cord-Stromal Tumor.

Pathways for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Pathways related to Testicular Sex Cord-Stromal Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5S100B, PGR
29.5CEACAM5, MUC1
3
Show member pathways
9.5VIM, DES
4
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.5VIM, DES

Compounds for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Compounds related to Testicular Sex Cord-Stromal Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1orcein449.5S100B, DES, VIM
2eosin449.4MUC1, S100B, VIM
3gold449.2SYP, DES, MUC1, CEACAM5
4ethanol44 50 24 1112.1SYP, S100B, MUC1, DES
54-hydroxytamoxifen449.0PGR, VIM, S100B
6ganglioside449.0CEACAM5, DES, VIM, SYP
7bezafibrate44 28 1110.9ALPP, VIM, DES
8acetylcholine44 50 28 24 1112.9S100B, SYP, DES, VIM
9gaba448.9PGR, S100B, SYP, VIM
10dihydrotestosterone44 28 24 1111.9DES, PGR, MUC1, VIM
11hyaluronic acid44 249.9MUC1, CEACAM5, VIM, DES
12dbc-amp448.8SYP, VIM, S100B
13norepinephrine44 24 1110.7SYP, DES, ALPP, S100B
14s 100448.7DES, VIM, MUC1, SYP, S100B
15reticulin448.7MUC1, VIM, DES, SYP, S100B
16formaldehyde44 249.7DES, SYP, VIM, MUC1, S100B
17agar448.7CEACAM5, MUC1, VIM, PGR
18procollagen448.7VIM, ALPP, DES
19choline44 24 1110.6SYP, S100B, ALPP, VIM
20steroid448.6S100B, CEACAM5, PGR, DES, SYP
21cyclic amp44 249.6SYP, S100B, MUC1, DES, VIM
22doxorubicin44 50 1110.6DES, CEACAM5, VIM, PGR
23neomycin448.6CEACAM5, VIM, ALPP
24forskolin44 50 1110.5MUC1, VIM, SYP, S100B
25hydroxyapatite448.5S100B, ALPP, CEACAM5, VIM
26chloramphenicol44 1 50 1111.5MUC1, S100B, ALPP, VIM
27adriamycin448.4PGR, DES, CEACAM5, MUC1, VIM
28folate448.4PGR, MUC1, VIM, ALPP
29dmso448.4MUC1, VIM, PGR, ALPP
30butyrate448.3ALPP, VIM, MUC1, CEACAM5
31tamoxifen44 50 28 1111.3VIM, MUC1, ALPP, PGR
32thymidine44 249.3S100B, DES, MUC1, CEACAM5, ALPP
33mucicarmine448.2MUC1, S100B, SYP, VIM, DES, CEACAM5
34hematoxylin448.2VIM, DES, S100B, SYP, CEACAM5, MUC1
35glycogen44 249.2CEACAM5, MUC1, DES, VIM, S100B, SYP
36genistein44 28 60 1 24 1113.2ALPP, PGR, VIM, SYP
37progestin448.1MUC1, VIM, PGR, DES, ALPP
38lactate448.1ALPP, CEACAM5, VIM, DES, S100B
39estradiol44 24 1110.1DES, SYP, CEACAM5, MUC1, VIM, PGR
40creatinine447.8S100B, ALPP, VIM, SYP, MUC1, DES
41serine447.7S100B, MUC1, SYP, VIM, DES, ALPP
42dexamethasone44 50 28 1110.7SYP, ALPP, MUC1, VIM, PGR, S100B
43progesterone44 28 60 24 1111.7CEACAM5, VIM, S100B, DES, SYP, PGR
44b 723447.4SYP, DES, VIM, S100B, ALPP, CEACAM5
45testosterone44 60 24 1110.4SYP, ALPP, MUC1, S100B, VIM, PGR
46retinoic acid44 248.3S100B, SYP, ALPP, MUC1, VIM, PGR
47paraffin446.8DES, PGR, VIM, MUC1, CEACAM5, SYP
48vegf446.8PGR, VIM, MUC1, CEACAM5, SYP, ALPP
49estrogen446.8DES, PGR, ALPP, MUC1, CEACAM5, SYP
50cysteine446.8PGR, DES, S100B, ALPP, SYP, CEACAM5

GO Terms for genes affiliated with Testicular Sex Cord-Stromal Tumor

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Biological processes related to Testicular Sex Cord-Stromal Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.5VIM, DES
2regulation of neuronal synaptic plasticityGO:00481689.4S100B, SYP

Molecular functions related to Testicular Sex Cord-Stromal Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:00428028.2S100B, SYP, CEACAM5, VIM, DES

Sources for Testicular Sex Cord-Stromal Tumor

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet