MCID: TST040
MIFTS: 22

Testicular Trophoblastic Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Testicular Trophoblastic Tumor

MalaCards integrated aliases for Testicular Trophoblastic Tumor:

Name: Testicular Trophoblastic Tumor 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4084
NCIt 47 C39934
UMLS 69 C1515301

Summaries for Testicular Trophoblastic Tumor

MalaCards based summary : Testicular Trophoblastic Tumor is related to testicular pure germ cell tumor and gingival hypertrophy. An important gene associated with Testicular Trophoblastic Tumor is CSH1 (Chorionic Somatomammotropin Hormone 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Prolactin Signaling Pathway. The drugs Amphotericin B and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and liver.

Related Diseases for Testicular Trophoblastic Tumor

Graphical network of the top 20 diseases related to Testicular Trophoblastic Tumor:



Diseases related to Testicular Trophoblastic Tumor

Symptoms & Phenotypes for Testicular Trophoblastic Tumor

Drugs & Therapeutics for Testicular Trophoblastic Tumor

Drugs for Testicular Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 150)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
2
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
3
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
4
Palivizumab Approved, Investigational Phase 3 188039-54-5
5
Ribavirin Approved Phase 3 36791-04-5 37542
6
Fluconazole Approved Phase 3 86386-73-4 3365
7
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
8
Captopril Approved Phase 3 62571-86-2 44093
9
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
10
Etoposide Approved Phase 3,Phase 1 33419-42-0 36462
11
Bleomycin Approved Phase 3 11056-06-7 5360373
12
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
13
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
14
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
15
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
16
Norgestimate Approved Phase 3 35189-28-7 6540478
17
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
18
Mycophenolic acid Approved Phase 3 24280-93-1 446541
19 Anti-Bacterial Agents Phase 3,Phase 1
20 Antifungal Agents Phase 3,Phase 2
21 Anti-Infective Agents Phase 3,Phase 2,Phase 1
22 Antiparasitic Agents Phase 3
23 Antiprotozoal Agents Phase 3
24 Liposomal amphotericin B Phase 3
25 Echinocandins Phase 3,Phase 2
26 Antibodies Phase 3,Phase 2,Phase 1
27 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
28 Antimetabolites Phase 3,Phase 2
29 Antiviral Agents Phase 3,Phase 2
30 Immunoglobulins Phase 3,Phase 2,Phase 1
31 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
32 Cytochrome P-450 CYP3A Inhibitors Phase 3
33 Cytochrome P-450 Enzyme Inhibitors Phase 3
34 Hormone Antagonists Phase 3,Phase 1,Phase 2
35 Hormones Phase 3,Phase 1,Phase 2
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
37 Hydroxyitraconazole Phase 3
38 Steroid Synthesis Inhibitors Phase 3
39 Alkylating Agents Phase 3,Phase 2,Phase 1
40 Angiotensin-Converting Enzyme Inhibitors Phase 3
41 Antihypertensive Agents Phase 3
42 Antirheumatic Agents Phase 3,Phase 2
43 HIV Protease Inhibitors Phase 3
44 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
45
protease inhibitors Phase 3
46 Acyclovir Phase 3
47 valacyclovir Phase 3
48 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
49 Etoposide phosphate Phase 3,Phase 1
50 Topoisomerase Inhibitors Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 52)

id Name Status NCT ID Phase Drugs
1 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
2 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
3 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
4 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
5 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
6 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
7 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
8 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Active, not recruiting NCT00053352 Phase 3 cisplatin;etoposide
9 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
10 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
11 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
12 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
13 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
14 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
15 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
16 Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation Completed NCT00064311 Phase 1, Phase 2 ravuconazole
17 Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant Completed NCT00410657 Phase 2 methylprednisolone;prednisone
18 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2 ondansetron
19 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
20 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
21 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
22 Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant Completed NCT00357084 Phase 2 methotrexate;methylprednisolone;prednisone
23 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
24 Emergency Use of Donor Lymphocytes in Treating Patients Who Have Undergone Donor Stem Cell Transplant and Have Cytomegalovirus Infections Unknown status NCT00769613 Phase 1
25 Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions Unknown status NCT00066404 Phase 1
26 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
27 Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia Completed NCT01484015 Phase 1 cefepime hydrochloride
28 Donor Natural Killer Cell Infusion in Preventing Relapse or Graft Failure in Patients Who Have Undergone Donor Bone Marrow Transplant Completed NCT00569283 Phase 1
29 Vaccine Therapy in Treating Patients Who Have Undergone a Donor Stem Cell Transplant and Have Cytomegalovirus Infection That Has Not Responded to Therapy Completed NCT00509691 Phase 1
30 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
31 Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors Completed NCT00003597 Phase 1 carboplatin;etoposide;ifosfamide
32 Donor Mesenchymal Stem Cell Infusion in Treating Patients With Acute or Chronic Graft-Versus-Host Disease After Undergoing a Donor Stem Cell Transplant Completed NCT00361049 Phase 1
33 Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00957736 Phase 1
34 Aprepitant, Granisetron, & Dexamethasone in Preventing Nausea & Vomiting in Pts. Receiving Cyclophosphamide Before a Stem Cell Transplant Completed NCT00293384 Aprepitant;Cyclophosphamide;Dexamethasone;Granisetron hydrochloride
35 Study of the Emotional Needs of Caregivers of Stem Cell Transplantation Patients Completed NCT00082654
36 Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant Completed NCT00408681 lithium carbonate
37 Collecting and Storing Tissue and DNA Samples From Patients Undergoing a Donor Stem Cell Transplant Completed NCT00900406
38 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465
39 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021
40 Prevention of Graft-Versus-Host Disease in Patients Undergoing Bone Marrow Transplantation Completed NCT00003538
41 Aprepitant in Preventing Nausea and Vomiting in Patients Who Are Undergoing a Stem Cell Transplant Completed NCT00248547 aprepitant;dexamethasone;ondansetron;placebo
42 A Structured Walking Program or Standard Therapy in Cancer Patients Undergoing a Donor Bone Marrow Transplant Completed NCT00445731
43 Voriconazole Compared With Itraconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00079222 itraconazole;voriconazole
44 Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer Completed NCT01764789
45 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355
46 Genetic Susceptibility and Risk of Second Cancers in Patients Who Have Undergone Stem Cell Transplant for Cancer Active, not recruiting NCT00949052
47 T Cells in Predicting Acute Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant Suspended NCT00651716
48 Blood Samples From Patients on a Clinical Trial to CINV During HSCT Terminated NCT00900068
49 Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload Terminated NCT01159067 deferasirox
50 Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant Withdrawn NCT01558778

Search NIH Clinical Center for Testicular Trophoblastic Tumor

Genetic Tests for Testicular Trophoblastic Tumor

Anatomical Context for Testicular Trophoblastic Tumor

MalaCards organs/tissues related to Testicular Trophoblastic Tumor:

39
Bone, Bone Marrow, Liver, Colon, T Cells, Small Intestine

Publications for Testicular Trophoblastic Tumor

Variations for Testicular Trophoblastic Tumor

Expression for Testicular Trophoblastic Tumor

Search GEO for disease gene expression data for Testicular Trophoblastic Tumor.

Pathways for Testicular Trophoblastic Tumor

Pathways related to Testicular Trophoblastic Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.69 CSH1 CSH2
2
Show member pathways
11.41 CSH1 CSH2
3
Show member pathways
10.86 CSH1 CSH2

GO Terms for Testicular Trophoblastic Tumor

Cellular components related to Testicular Trophoblastic Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 vesicle GO:0031982 8.62 CSH1 CSH2

Molecular functions related to Testicular Trophoblastic Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 CSH1 CSH2

Sources for Testicular Trophoblastic Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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