MCID: TTN003
MIFTS: 63

Tetanus malady

Rare diseases, Neuronal diseases, Infectious diseases categories
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Summaries for Tetanus

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8Disease Ontology, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Tetanus is a serious illness caused by clostridium bacteria. the bacteria live in soil, saliva, dust, and manure. the bacteria can enter the body through a deep cut, like those you might get from stepping on a nail, or through a burn. the infection causes painful tightening of the muscles, usually all over the body. it can lead to "locking" of the jaw. this makes it impossible to open your mouth or swallow. tetanus is a medical emergency. you need to get treatment in a hospital. a vaccine can prevent tetanus. it is given as a part of routine childhood immunization. adults should get a tetanus shot, or booster, every 10 years. if you get a bad cut or burn, see your doctor - you may need a booster. immediate and proper wound care can prevent tetanus infection.

MalaCards: Tetanus, also known as infection due to clostridium tetani, is related to influenza and systemic lupus erythematosus. An important gene associated with Tetanus is VAMP7 (vesicle-associated membrane protein 7), and among its related pathways are Fc-GammaR Pathway and Taste transduction. The drugs chlorpromazine and chlorpromazine hydrochloride and the compounds cardiolipin and gabapentin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and skeletal muscle, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A primary bacterial infectious disease that results in prolonged contraction of skeletal muscle fibers, has material basis in clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.

CDC:4 Tetanus is an infection caused by bacteria called Clostridium tetani. When the bacteria invade the body, they produce a poison (toxin) that causes painful muscle contractions. Another name for tetanus is "lockjaw" because it often causes a person's neck and jaw muscles to lock, making it hard to open the mouth or swallow. Vaccines are recommended for infants, children, teens and adults to prevent tetanus.

Wikipedia:65 Tetanus (from Ancient more...

Aliases & Classifications for Tetanus

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 62UMLS, 40NCIt, 35MeSH, 27ICD9CM, 58SNOMED-CT, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

tetanus 8 43 10 45 49 34 62
infection due to clostridium tetani 8
clostridial tetanus 8
lockjaw 43


External Ids:

Disease Ontology8 DOID:11338
NCIt40 C85185
MeSH35 D013742
ICD9CM27 037
SNOMED-CT via Orphanet59 76902006, 276202003
UMLS via Orphanet63 C0039614
MESH via Orphanet36 D013742
ICD10 via Orphanet26 A33, A34, A35

Related Diseases for Tetanus

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tetanus:



Diseases related to tetanus

Symptoms for Tetanus

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Drugs & Therapeutics for Tetanus

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Tetanus

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Anatomical Context for Tetanus

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33MalaCards
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MalaCards organs/tissues related to Tetanus:

33
Spinal cord, Brain, Skeletal muscle, T cells, Testes, B cells, Temporal lobe, Breast, Heart, Cortex, Monocytes, Kidney, Tongue

Animal Models for Tetanus or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Tetanus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5MPZ, VAMP3, CCR7, IL9, CACNA1B, GABBR1
2MP:00053977.3CD79A, VAMP3, CCR7, IL9, CD27, MPZ
3MP:00053877.2CD79A, MPZ, VAMP2, VAMP3, IL9, CD27
4MP:00036316.7CD79A, GABBR1, CACNA1B, CCR7, VAMP3, VAMP2

Publications for Tetanus

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52PubMed
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Articles related to Tetanus:

(show top 50)    (show all 879)
idTitleAuthorsYear
1
Complex regional pain syndrome type I following tetanus toxoid injection. (24356477)
2014
2
Production and characterization of recombinant light chain and carboxyterminal heavy chain fragments of tetanus toxin. (24285996)
2013
3
Persistence of antibodies for 42 months following vaccination of adolescents with a meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine (MenACWY-TT). (23246368)
2013
4
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrixa8c hexa: Twelve years of experience in Italy. (24004825)
2013
5
Three-year antibody persistence and safety after a single dose of combined haemophilus influenzae type b (Hib)-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in Hib-primed toddlers. (23080288)
2013
6
Impaired cellular immune response to tetanus toxoid but not to cytomegalovirus in effectively HAART-treated HIV-infected children. (23562610)
2013
7
Incremental costs of treating tetanus with intrathecal antitetanus immunoglobulin. (23461581)
2013
8
Randomized, controlled, multicenter study of the immunogenicity and safety of a fully liquid combination diphtheria-tetanus toxoid-five-component acellular pertussis (DTaP5), inactivated poliovirus (IPV), and haemophilus influenzae type b (Hib) vaccine compared with a DTaP3-IPV/Hib vaccine administered at 3, 5, and 12 months of age. (23966556)
2013
9
Leukocyte transcript alterations in West-African girls following a booster vaccination with diphtheria-tetanus-pertussis vaccine. (23668887)
2013
10
Self-adjuvanting synthetic antitumor vaccines from MUC1 glycopeptides conjugated to T-cell epitopes from tetanus toxoid. (23616304)
2013
11
Chronological changes in inflammatory cytokines immunoreactivities in the mouse hippocampus after systemic administration of high dosage of tetanus toxin. (22990290)
2012
12
Evaluation of specific immune responses to BoNT/A and tetanus toxoid in patients undergoing treatment for neurologic disorders. (22385115)
2012
13
Vaccine model of antiphospholipid syndrome induced by tetanus vaccine. (22235053)
2012
14
Identification of a novel linear epitope in tetanus toxin recognized by a protective monoclonal antibody: implications for vaccine design. (22889825)
2012
15
Meningococcal quadrivalent (serogroups A, C, W135 and Y) tetanus toxoid conjugate vaccine (Nimenrixa8c). (23231026)
2012
16
Mucosal Adjuvant Potential of Quillaja saponins and Cross-linked Dextran Microspheres, Co-administered with Liposomes Encapsulated with Tetanus Toxoid. (24250499)
2012
17
Influenza and tetanus, diphtheria, and acellular pertussis vaccinations during pregnancy. (22495061)
2012
18
Experimental design to optimize an Haemophilus influenzae type b conjugate vaccine made with hydrazide-derivatized tetanus toxoid. (21850577)
2011
19
Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) in pregnant women and persons who have or anticipate having close contact with an infant aged <12 months --- Advisory Committee on Immunization Practices (ACIP), 2011. (22012116)
2011
20
Safety and immunogenicity of three different formulations of a liquid hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine at 2, 4, 6 and 12-14 months of age. (21134456)
2011
21
The effect of vitamin A supplementation and diphtheria-tetanus-pertussis vaccination on parasitaemia in an experimental murine malaria model. (21105844)
2011
22
Effect of an audiovisual message for tetanus booster vaccination broadcast in the waiting room. (21955570)
2011
23
Magnesium sulphate for treatment of tetanus in adults. (20191795)
2010
24
Efficacy, heat stability and safety of intranasally administered Bacillus subtilis spore or vegetative cell vaccines expressing tetanus toxin fragment C. (20709005)
2010
25
Human monoclonal ScFv that inhibits cellular entry and metalloprotease activity of tetanus neurotoxin. (20527521)
2010
26
Primary and booster immunization with a diphtheria, tetanus, acellular pertussis, hepatitis B (DTPa-HBV) and Haemophilus influenzae type b (Hib) vaccine administered separately or together is safe and immunogenic. (19467896)
2010
27
Determinants of the uptake of the full dose of diphtheria-pertussis-tetanus vaccines (DPT3) in Northern Nigeria: a multilevel analysis. (18607704)
2009
28
Combined, reduced-antigen content tetanus, diphtheria, and acellular pertussis vaccine (Boostrix): a review of its use as a single-dose booster immunization in individuals aged 10-64 years in the US. (19697967)
2009
29
A novel, helminth-derived immunostimulant enhances human recall responses to hepatitis C virus and tetanus toxoid and is dependent on CD56+ cells for its action. (18341617)
2008
30
A simple and rapid method for quantifying 2-phenoxyethanol (2-PE) in Diphtheria, Tetanus and w-Pertussis (DTwP) vaccine. (17728142)
2008
31
An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine and diphtheria and tetanus toxoids adsorbed combined with inactivated poliomyelitis vaccine. (17045366)
2007
32
The immunological response of Thai infants to haemophilus influenzae type B polysaccharide-tetanus conjugate vaccine co-administered in the same syringe with locally produced diphtheria-tetanus-pertussis vaccine. (17710973)
2007
33
Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy. (15717298)
2005
34
Human onchocerciasis and tetanus vaccination: impact on the postvaccination antitetanus antibody response. (10531253)
1999
35
Acute disseminated encephalomyelitis associated with tetanus vaccination. (10343155)
1999
36
A chronic focal epilepsy with mossy fiber sprouting follows recurrent seizures induced by intrahippocampal tetanus toxin injection in infant rats. (10392831)
1999
37
An anti-CD19 antibody coupled to a tetanus toxin peptide induces efficient Fas ligand (FasL)-mediated cytotoxicity of a transformed human B cell line by specific CD4+ T cells. (9822273)
1998
38
Tetanus as a cause of acute renal failure: possible role of rhabdomyolysis. (8115681)
1993
39
Isotype composition of antibodies to streptococcus group B type III polysaccharide and to tetanus toxoid in maternal, cord blood sera and in breast milk. (1537371)
1992
40
Traditional birth attendants in an endemic area of tetanus neonatorum in Thailand: pitfalls in the control program. (1774348)
1991
41
Role of intrathecal tetanus antitoxin (equine) in tetanus neonatorum. (2754273)
1989
42
Double-blind trial of intramuscular and intramuscular plus intrathecal human tetanus immunoglobulin and intramuscular equine tetanus antitoxin in the treatment of tetanus neonatorum. (3232228)
1988
43
Treatment of tetanus neonatorum in a rural setting. (6688850)
1983
44
Myositis ossificans localisata as a complication of tetanus. (525320)
1979
45
Cause of death in tetanus neonatorum: study of 233 cases with 54 necropsies. (879851)
1977
46
Experiences in the management of tetanus neonatorum with particular reference to the role of diazepam. (4839236)
1974
47
Treatment of tetanus neonatorum. (5335337)
1966
48
SOME MODIFICATIONS IN METHOD OF TREATING TETANUS NEONATORUM WITH INTERMITTENT POSITIVE-PRESSURE RESPIRATION. (14160093)
1964
49
Tetanus neonatorum treated with chlorpromazine, tetanus antiserum and penicillin. (13461072)
1957
50
Two cases of tetanus neonatorum. (18867940)
1948

Variations for Tetanus

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Expression for genes affiliated with Tetanus

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tetanus

Search GEO for disease gene expression data for Tetanus.

Pathways for genes affiliated with Tetanus

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50PathCards, 53QIAGEN, 30KEGG, 55Reactome, 38NCBI BioSystems Database, 51PharmGKB
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Compounds for genes affiliated with Tetanus

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45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Tetanus according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1cardiolipin45 1111.0MPZ, CD79A
2gabapentin45 24 1111.9CACNA1B, GABBR1
3methacholine45 51 1111.9CD79A, IL9
4cnqx45 6110.9GABBR1, CACNA1B
5valproate459.9GABBR1, CD79A
6okt3459.7CD79A, HTLVR
7tarc459.7IL9, CCR7
8clonidine45 51 29 1112.7CACNA1B, GABBR1
9histamine45 29 2411.6IL9, GABBR1, CD79A
10allergens459.5CD79A, IL9
11gaba459.1GABBR1, VAMP2, CACNA1B
12norepinephrine45 24 1111.1CACNA1B, CCR7, GABBR1, CD79A
13nmda45 2910.0VAMP2, CACNA1B, GABBR1
14pge2459.0CCR7, CACNA1B, CD79A
15cysteine458.9CD79A, CD27, CACNA1B, MPZ, GABBR1
16acetylcholine45 51 29 24 1112.8VAMP2, CACNA1B, GABBR1, CD79A
17dopamine45 29 24 1111.7CACNA1B, CD79A, VAMP2, GABBR1
18hydrogen45 249.7VAMP2, CACNA1B, VAMP3
19lipid458.5IL9, MPZ, VAMP2, CCR7
20phosphatidylinositol458.4VAMP2, CACNA1B, CCR7, VAMP3
21glutamate458.4GABBR1, CACNA1B, CD79A, VAMP2, MPZ
22tyrosine458.3VAMP2, GABBR1, IL9, MPZ, CCR7
23calcium45 51 24 1111.0CD27, GABBR1, CACNA1B, CCR7, VAMP2, VAMP7

GO Terms for genes affiliated with Tetanus

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16Gene Ontology
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Cellular components related to Tetanus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3CD79A, CD27, CCR7
2synaptic vesicleGO:0080219.1VAMP3, VAMP2
3clathrin-coated vesicleGO:0301369.0VAMP2, VAMP3
4SNARE complexGO:0312019.0VAMP3, VAMP2, VAMP7
5neuron projectionGO:0430058.9VAMP3, VAMP2, VAMP7
6cell junctionGO:0300548.6VAMP7, VAMP2, VAMP3, GABBR1
7integral component of plasma membraneGO:0058878.3CD27, GABBR1, VAMP2, MPZ
8plasma membraneGO:0058866.9MPZ, VAMP7, VAMP2, VAMP3, CCR7, CACNA1B

Biological processes related to Tetanus according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1Golgi to plasma membrane protein transportGO:0430019.7VAMP3, VAMP7
2exocytosisGO:0068879.7VAMP3, VAMP7
3positive regulation of JNK cascadeGO:0463309.4CD27, CCR7
4post-Golgi vesicle-mediated transportGO:0068929.3VAMP7, VAMP2
5calcium ion-dependent exocytosisGO:0171569.0VAMP3, VAMP2, VAMP7
6vesicle fusionGO:0069069.0VAMP7, VAMP2, VAMP3
7neurotransmitter secretionGO:0072698.8CACNA1B, VAMP3, VAMP2
8synaptic transmissionGO:0072688.5MPZ, VAMP2, CACNA1B, GABBR1

Molecular functions related to Tetanus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1syntaxin bindingGO:0199059.4VAMP2, VAMP7
2SNARE bindingGO:0001499.4VAMP3, VAMP7
3SNAP receptor activityGO:0054848.7VAMP3, VAMP2, VAMP7

Products for genes affiliated with Tetanus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tetanus

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet