MCID: TTN003
MIFTS: 60

Tetanus malady

Neuronal, Infectious categories

Summaries for Tetanus

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Tetanus is a serious illness caused by clostridium bacteria. the bacteria live in soil, saliva, dust, and manure. the bacteria can enter the body through a deep cut, like those you might get from stepping on a nail, or through a burn. the infection causes painful tightening of the muscles, usually all over the body. it can lead to "locking" of the jaw. this makes it impossible to open your mouth or swallow. tetanus is a medical emergency. you need to get treatment in a hospital. a vaccine can prevent tetanus. it is given as a part of routine childhood immunization. adults should get a tetanus shot, or booster, every 10 years. if you get a bad cut or burn, see your doctor - you may need a booster. immediate and proper wound care can prevent tetanus infection.

MalaCards: Tetanus, also known as infection due to clostridium tetani, is related to tetanus neonatorum and arthritis. An important gene associated with Tetanus is VAMP7 (vesicle-associated membrane protein 7), and among its related pathways are PEDF Induced Signaling and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The drugs chlorpromazine and methocarbamol and the compounds calcium and lipid have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are cellular and hematopoietic system.

Disease Ontology:8 A primary bacterial infectious disease that results in prolonged contraction of skeletal muscle fibers, has material basis in clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.

CDC:3 Tetanus is an infection caused by bacteria called Clostridium tetani. When the bacteria invade the body, they produce a poison (toxin) that causes painful muscle contractions. Another name for tetanus is "lockjaw" because it often causes a person's neck and jaw muscles to lock, making it hard to open the mouth or swallow. Vaccines are recommended for infants, children, teens and adults to prevent tetanus.

Wikipedia:64 Tetanus (from Ancient more...

Aliases & Classifications for Tetanus

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 27ICD9CM, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Neuronal


Aliases & Descriptions:

tetanus 8 43 10 45 49 34 61
infection due to clostridium tetani 8
clostridial tetanus 8
lockjaw 43


External Ids:

Disease Ontology8 DOID:11338
MeSH35 D013742
NCIt40 C85185
ICD9CM27 037
SNOMED-CT via Orphanet58 76902006, 276202003
UMLS via Orphanet62 C0039614
MESH via Orphanet36 D013742
ICD10 via Orphanet26 A33, A34, A35

Related Diseases for Tetanus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tetanus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1tetanus neonatorum31.4ACE2, MNT
2arthritis30.2CD69, CCR7
3diphtheria11.1
4hepatitis d10.7
5hepatitis c10.7
6hepatitis a10.7
7measles10.5
8rubella10.4
9myositis ossificans10.4
10mumps10.4
11hepatitis b10.3
12hepatitis e10.2
13hepatitis c virus10.2
14myelitis10.2
15lepromatous leprosy10.2
16transverse myelitis10.2
17autonomic dysfunction10.2
18rabies10.1
19onchocerciasis10.1
20reactive arthritis10.1
21botulism10.1
22noma10.0
23antiphospholipid syndrome10.0
24temporal lobe epilepsy10.0
25systemic lupus erythematosus10.0
26acute disseminated encephalomyelitis10.0
27n syndrome10.0
28thrombocytopenia10.0
29wells syndrome10.0
30head injury10.0
31sepsis10.0
32acute transverse myelitis10.0
33ipex syndrome10.0CSN2, CD27, CCR7, FLT3LG, MPP1, CD69
34multiple sclerosis10.0CCR7, IL9, CD27, HTLVR, CSN2, CD69
35hypersensitivity reaction type ii disease10.0HTLVR, PMEL, CCR7, CSN2, CD69, IL9
36leukemia10.0CCR7, IL9, CD27, FLT3LG, HTLVR
37melanoma10.0MPP1, PMEL, FLT3LG, CD27, CCR7
38influenza10.0CD69, CCR7, PMEL, CD27
39non-hodgkin lymphoma10.0FLT3LG, CD27, IL9, CCR7
40malignant glioma10.0PMEL, CACNA1B, FLT3LG, CD27, STX1A
41immunodeficiency with hyper igm type 210.0CD69, CCR7, PVALB, CSN2
42myeloid leukemia10.0IL9
43sarcoidosis10.0CD69, CD27, IL9
44insulinoma10.0VAMP2
45graves' disease10.0HTLVR, CD69
46human immunodeficiency virus infectious disease10.0CD69, CD27
47b-cell chronic lymphocytic leukemia10.0CD69, CD27, CCR7
48burkitt's lymphoma10.0CD27, MPP1, IL9, CD69, CCR7
49common variable immune deficiency10.0CD27
50type 1 diabetes10.0HTLVR, CD69, CSN2

Graphical network of the top 20 diseases related to Tetanus:



Diseases related to tetanus

Clinical Features for Tetanus

Drugs & Therapeutics for Tetanus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Tetanus

Anatomical Context for Tetanus

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Tetanus:

33
Whole blood, Brain, Cortex, Spinal cord, Heart, Skeletal muscle, Kidney, Breast, Monocytes, T cells, B lymphoblasts, B cells, Temporal lobe, Tongue

Animal Models for Tetanus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Tetanus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538410.7CCR7, FLT3LG, MPP1, MNT, CD69, RIPK4
2MP:000539710.6IL9, PMEL, CCR7, FLT3LG, CD69, CD27
3MP:000538710.4CCR7, FLT3LG, MPP1, CD69, CD27, VAMP3

Publications for Tetanus

Sources:
51PubMed
See all sources

Articles related to Tetanus:

(show top 50)    (show all 885)
idTitleAuthorsYear
1
Enhanced immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to dendritic cells via Dectin-1 by incorporating I^-glucan. (23514738)
2013
2
Trismus in cephalic tetanus from a foot injury. (23346010)
2013
3
The relationship between tetanus intensity and the magnitude of hippocampal long-term potentiation in vivo. (23228809)
2013
4
Immunogenicity and safety after booster vaccination of diphtheria, tetanus, and acellular pertussis in young adults: an open randomized controlled trial in Japan. (24108779)
2013
5
Protective status of end-stage renal disease children against tetanus and diphtheria vaccination. (23671773)
2013
6
Immunity Against Tetanus Infection, Risk Factors for Non-Protection, and Validation of a Rapid Immunotest Kit among Hospitalized Children in Nigeria. (24069018)
2013
7
Supplementation with natural forms of vitamin E augments antigen-specific TH1-type immune response to tetanus toxoid. (23936847)
2013
8
Diphtheria, pertussis (whooping cough), and tetanus vaccine induced recurrent seizures and acute encephalopathy in a pediatric patient: Possibly due to pertussis fraction. (22368426)
2012
9
Tetanus toxoid IgE may be useful in predicting allergy during childhood. (22691259)
2012
10
Prevalence of susceptibility to tetanus and diphtheria in health care workers in Catalonia. (22386155)
2012
11
Tetanus seropositive prevalence and perceived protection from emergency admissions. (22461848)
2012
12
Persistence of humoral immunity to tetanus and diphtheria in hematopoietic stem cell transplant recipients after post-transplant immunization. (22514148)
2012
13
Longitudinal analysis of tetanus- and influenza-specific IgG antibodies in myeloma patients. (22481961)
2012
14
Tetanus vaccine in UIP in India. (22318109)
2012
15
A case of cephalic tetanus with unilateral ptosis and facial palsy. (22506253)
2012
16
The effect of magnesium sulfate on uncontrollable contractions in a tetanus case. (22472653)
2012
17
Tetanus. (23193550)
2012
18
Experimental design to optimize an Haemophilus influenzae type b conjugate vaccine made with hydrazide-derivatized tetanus toxoid. (21850577)
2011
19
Comments on cow's milk allergy and diphtheria, tetanus, and pertussis vaccines. (21807255)
2011
20
Calibration of the Ph. Eur. Biological Reference Preparation (BRP) for tetanus vaccine (adsorbed) batch 3. (21619853)
2011
21
A conformational change of C fragment of tetanus neurotoxin reduces its ganglioside-binding activity but does not destroy its immunogenicity. (21813664)
2011
22
Recurrent generalized tetanus: a case report. (21421889)
2011
23
Mucosal and systemic immune responses of mice to tetanus toxoid coadministered nasally with AFCo1. (21358768)
2011
24
Risk factors, morbidity and mortality of neonatal tetanus. (21240163)
2011
25
Progressive muscle weakness with respiratory insufficiency in a young patient with tetanus during magnesium sulfate infusion. (20864066)
2010
26
Antiphospholipid syndrome following a diphtheria-tetanus vaccination: coincidence vs. causality. (21090524)
2010
27
Prolonged high-dose intravenous magnesium therapy for severe tetanus in the intensive care unit: a case series. (20356376)
2010
28
An open-label, single-arm, phase I study to evaluate the safety and immunogenicity of LBVH0101, a new Haemophilus influenzae type b tetanus toxoid conjugate vaccine, in healthy adult volunteers. (20607497)
2010
29
Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study. (19804643)
2009
30
Concomitant use of the 3-dose oral pentavalent rotavirus vaccine with a 3-dose primary vaccination course of a diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio-Haemophilus influenzae type b vaccine: immunogenicity and reactogenicity. (19209092)
2009
31
Effects of a minimum interval immunization schedule for diphtheria and tetanus toxoids and acellular pertussis vaccination during a pertussis outbreak. (19414686)
2009
32
The value of booster vaccinations against diphtheria, tetanus, pertussis and poliomyelitis. (18792533)
2008
33
Seroimmunity to diphtheria and tetanus among mother-infant pairs; the role of maternal immunity on infant immune response to diphtheria-tetanus vaccination. (18481231)
2008
34
Levels of diphtheria and tetanus specific IgG of Portuguese adult women, before and after vaccination with adult type Td. Duration of immunity following vaccination. (17565697)
2007
35
Tetanus neurotoxin-mediated cleavage of cellubrevin impairs epithelial cell migration and integrin-dependent cell adhesion]. (16197886)
2005
36
A case of granuloma annulare in a child following tetanus and diphtheria toxoid vaccination. (16164728)
2005
37
Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy. (15274078)
2004
38
Instruments for oral disease-intervention strategies: recombinant Lactobacillus casei expressing tetanus toxin fragment C for vaccination or myelin proteins for oral tolerance induction in multiple sclerosis. (10367944)
1999
39
Effect of rIL-2 treatment on anti-tetanus toxoid response in the elderly. (9089584)
1997
40
Immune responses of young mice to pneumococcal type 9V polysaccharide-tetanus toxoid conjugate. (8005665)
1994
41
Esophageal hiatal hernia and megaesophagus complicating tetanus in two dogs. (1885336)
1991
42
The influence of pyridoxin in the treatment of tetanus neonatorum. (1896198)
1991
43
Detection of intracellular expression and secretion of interferon-gamma at the single-cell level after activation of human T cells with tetanus toxoid in vitro. (2113474)
1990
44
Pyridoxine in the treatment of tetanus neonatorum. (2488239)
1989
45
Treatment of tetanus neonatorum in a rural setting. (6688850)
1983
46
Cause of death in tetanus neonatorum: study of 233 cases with 54 necropsies. (879851)
1977
47
Control of tetanus neonatorum in rural communities--immunization effects of high-dose calcium phosphate-absorbed tetanus toxoid. (346478)
1977
48
Treatment of tetanus neonatorum with muscle relaxants and intermittent positive-pressure ventilation. (4131848)
1974
49
Experimental clostridial wounds in rabbits. I. The effect of debridement delay, tetanus immunization, and topical antibiotics on the mortality from gas gangrene. (5941140)
1966
50
Motor neuritis after tetanus antitoxin with involvement of the muscles of respiration. (14837920)
1951

Genetic Variations for Tetanus

Expression for genes affiliated with Tetanus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tetanus

Search GEO for disease gene expression data for Tetanus.

Pathways for genes affiliated with Tetanus

Sources:
52QIAGEN, 30KEGG, 50PharmGKB, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome
See all sources

Compounds for genes affiliated with Tetanus

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Tetanus according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2414.1VTI1B, PVALB, CCR7, CACNA1B, CSN2, STX1A
2lipid4510.9CCR7, CSN2, STX1A, MPP1, CD69, VAMP2
3tyrosine4510.9PVALB, CCR7, CSN2, FLT3LG, MPP1, CD69
4phosphatidylinositol4510.9CCR7, CACNA1B, CSN2, CD69, VAMP3, VAMP2
5allergens4510.8PVALB, CSN2, CD69, IL9
6glutamate4510.8PVALB, CACNA1B, CSN2, STX1A, MPP2, VAMP2
7chloride4510.8PVALB, STX1A, IL9, ACE2
8cysteine4510.8VTI1B, CD27, MPP2, STX1A, CSN2, CACNA1B
9gaba4510.7PVALB, CACNA1B, STX1A, VAMP2
10glucose4510.6VTI1B, VAMP2, VAMP3, MPP2, MPP1, STX1A
11n-ethylmaleimide45 1111.6VAMP3, VAMP2, VTI1B
12h2o4510.5CSN2, PVALB
13latex4510.5PVALB, CCR7, CSN2
14serine4510.3IL9, RIPK4, VAMP2, CD69, CSN2, PVALB

GO Terms for genes affiliated with Tetanus

Sources:
16Gene Ontology
See all sources

Cellular components related to Tetanus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SNARE complexGO:03120110.7VTI1B, VAMP2, VAMP7, VAMP3, STX1A
2neuron projectionGO:04300510.7STX1A, VAMP3, VAMP7, VAMP2
3membraneGO:01602010.6RIPK4, VAMP2, MPP2, MPP1, FLT3LG
4synaptobrevin 2-SNAP-25-syntaxin-1a complexGO:07004410.5STX1A, VAMP2
5synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complexGO:07003210.4STX1A, VAMP2
6cell junctionGO:03005410.3STX1A, VAMP3, VAMP7, VAMP2

Biological processes related to Tetanus according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1calcium ion-dependent exocytosisGO:01715610.8VAMP2, VAMP7, VAMP3, STX1A
2Golgi to plasma membrane protein transportGO:04300110.7VAMP3, VAMP7, VAMP2
3neurotransmitter secretionGO:00726910.7VAMP2, STX1A, CACNA1B
4autophagic vacuole fusionGO:00004610.6VAMP7, VTI1B
5glutamate secretionGO:01404710.5VAMP2, STX1A
6membrane fusionGO:06102510.5VTI1B, VAMP3
7vesicle-mediated transportGO:01619210.5VAMP3, VAMP7, VTI1B
8vesicle docking involved in exocytosisGO:00690410.2VTI1B, VAMP3

Molecular functions related to Tetanus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1syntaxin-1 bindingGO:01707510.5VAMP2, VAMP3
2guanylate kinase activityGO:00438510.2MPP2, MPP1

Products for genes affiliated with Tetanus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tetanus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet