MCID: TTN003
MIFTS: 54

Tetanus malady

Rare diseases, Neuronal diseases, Infectious diseases categories

Aliases & Classifications for Tetanus

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 32MedlinePlus, 3CDC, 60UMLS, 27ICD9CM, 55SNOMED-CT, 33MeSH, 38NCIt, 61UMLS via Orphanet, 34MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Tetanus, Aliases & Descriptions:

Name: Tetanus 9 41 11 43 47 32 3 60
Lockjaw 41 3
 
Infection Due to Clostridium Tetani 9
Clostridial Tetanus 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
tetanus:
Prevalence: <1/1000000 (France)


External Ids:

Disease Ontology9 DOID:11338
ICD9CM27 037
MeSH33 D013742
NCIt38 C85185
Orphanet47 3299
UMLS via Orphanet61 C0039614
MESH via Orphanet34 D013742
ICD10 via Orphanet26 A33, A34, A35

Summaries for Tetanus

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MedlinePlus:32 Tetanus is a serious illness caused by clostridium bacteria. the bacteria live in soil, saliva, dust, and manure. the bacteria can enter the body through a deep cut, like those you might get from stepping on a nail, or through a burn. the infection causes painful tightening of the muscles, usually all over the body. it can lead to "locking" of the jaw. this makes it impossible to open your mouth or swallow. tetanus is a medical emergency. you need to get treatment in a hospital. a vaccine can prevent tetanus. it is given as a part of routine childhood immunization. adults should get a tetanus shot, or booster, every 10 years. if you get a bad cut or burn, see your doctor - you may need a booster. immediate and proper wound care can prevent tetanus infection.

MalaCards based summary: Tetanus, also known as lockjaw, is related to influenza and systemic lupus erythematosus. An important gene associated with Tetanus is VAMP7 (vesicle-associated membrane protein 7), and among its related pathways are Fc-GammaR Pathway and Taste transduction. The drugs chlorpromazine and methocarbamol and the compounds cardiolipin and gabapentin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and heart, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:9 A primary bacterial infectious disease that results in prolonged contraction of skeletal muscle fibers, has material basis in clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.

CDC:3 Tetanus is an infection caused by bacteria called Clostridium tetani. When the bacteria invade the body, they produce a poison (toxin) that causes painful muscle contractions. Another name for tetanus is "lockjaw" because it often causes a person's neck and jaw muscles to lock, making it hard to open the mouth or swallow. Vaccines are recommended for infants, children, teens and adults to prevent tetanus.

Wikipedia:63 Tetanus, also known as lockjaw, is an infection characterized by muscle spasms. In the most common type... more...

Related Diseases for Tetanus

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Graphical network of the top 20 diseases related to Tetanus:



Diseases related to tetanus

Symptoms for Tetanus

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Drugs & Therapeutics for Tetanus

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Genetic Tests for Tetanus

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Anatomical Context for Tetanus

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MalaCards organs/tissues related to Tetanus:

31
Spinal cord, Brain, Heart, Bone, Skeletal muscle, T cells, Testes, B cells, Breast, Cortex, Temporal lobe, Kidney, Lung, Monocytes, Tongue, Neutrophil

Animal Models for Tetanus or affiliated genes

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MGI Mouse Phenotypes related to Tetanus:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5VAMP3, CCR7, IL9, CACNA1B, GABBR1, CD79A
2MP:00053977.3CD79A, MPZ, VAMP2, VAMP3, CCR7, IL9
3MP:00053877.2MPZ, VAMP2, VAMP3, CCR7, IL9, CD27
4MP:00036316.7MPZ, VAMP2, VAMP3, CCR7, CACNA1B, GABBR1

Publications for Tetanus

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Articles related to Tetanus:

(show top 50)    (show all 922)
idTitleAuthorsYear
1
Safety and immunogenocity of a novel combined Haemophilus ini-8uenzae type b-Neisseria meningitidis serogroups A and C-tetanus-toxoid conjugate vaccine in healthy Chinese children aged 6A months to 5A years old. (25833163)
2015
2
Cephalic Tetanus in an Immunized Teenager: An Unusual Case Report. (25856657)
2015
3
Immunity to diphtheria and tetanus among blood donors in Arak, central province of Iran. (25870753)
2014
4
The safety and efficacy of the tetanus vaccine intramuscularly versus subcutaneously in anticoagulated patients: a randomized clinical trial. (25168768)
2014
5
Complex regional pain syndrome type I following tetanus toxoid injection. (24356477)
2014
6
Vaccination with tetanus, diphtheria, and acellular pertussis vaccine of pregnant women enrolled in Medicaid--Michigan, 2011-2013. (25254561)
2014
7
Production and characterization of recombinant light chain and carboxyterminal heavy chain fragments of tetanus toxin. (24285996)
2013
8
Persistence of antibodies for 42 months following vaccination of adolescents with a meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine (MenACWY-TT). (23246368)
2013
9
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrixa8c hexa: Twelve years of experience in Italy. (24004825)
2013
10
Three-year antibody persistence and safety after a single dose of combined haemophilus influenzae type b (Hib)-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in Hib-primed toddlers. (23080288)
2013
11
Impaired cellular immune response to tetanus toxoid but not to cytomegalovirus in effectively HAART-treated HIV-infected children. (23562610)
2013
12
Incremental costs of treating tetanus with intrathecal antitetanus immunoglobulin. (23461581)
2013
13
Randomized, controlled, multicenter study of the immunogenicity and safety of a fully liquid combination diphtheria-tetanus toxoid-five-component acellular pertussis (DTaP5), inactivated poliovirus (IPV), and haemophilus influenzae type b (Hib) vaccine compared with a DTaP3-IPV/Hib vaccine administered at 3, 5, and 12 months of age. (23966556)
2013
14
Leukocyte transcript alterations in West-African girls following a booster vaccination with diphtheria-tetanus-pertussis vaccine. (23668887)
2013
15
Chronological changes in inflammatory cytokines immunoreactivities in the mouse hippocampus after systemic administration of high dosage of tetanus toxin. (22990290)
2012
16
Evaluation of specific immune responses to BoNT/A and tetanus toxoid in patients undergoing treatment for neurologic disorders. (22385115)
2012
17
Vaccine model of antiphospholipid syndrome induced by tetanus vaccine. (22235053)
2012
18
Identification of a novel linear epitope in tetanus toxin recognized by a protective monoclonal antibody: implications for vaccine design. (22889825)
2012
19
Meningococcal quadrivalent (serogroups A, C, W135 and Y) tetanus toxoid conjugate vaccine (Nimenrixa8c). (23231026)
2012
20
Mucosal Adjuvant Potential of Quillaja saponins and Cross-linked Dextran Microspheres, Co-administered with Liposomes Encapsulated with Tetanus Toxoid. (24250499)
2012
21
Experimental design to optimize an Haemophilus influenzae type b conjugate vaccine made with hydrazide-derivatized tetanus toxoid. (21850577)
2011
22
Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) in pregnant women and persons who have or anticipate having close contact with an infant aged &lt;12 months --- Advisory Committee on Immunization Practices (ACIP), 2011. (22012116)
2011
23
Safety and immunogenicity of three different formulations of a liquid hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine at 2, 4, 6 and 12-14 months of age. (21134456)
2011
24
The effect of vitamin A supplementation and diphtheria-tetanus-pertussis vaccination on parasitaemia in an experimental murine malaria model. (21105844)
2011
25
Effect of an audiovisual message for tetanus booster vaccination broadcast in the waiting room. (21955570)
2011
26
Magnesium sulphate for treatment of tetanus in adults. (20191795)
2010
27
Efficacy, heat stability and safety of intranasally administered Bacillus subtilis spore or vegetative cell vaccines expressing tetanus toxin fragment C. (20709005)
2010
28
Human monoclonal ScFv that inhibits cellular entry and metalloprotease activity of tetanus neurotoxin. (20527521)
2010
29
Determinants of the uptake of the full dose of diphtheria-pertussis-tetanus vaccines (DPT3) in Northern Nigeria: a multilevel analysis. (18607704)
2009
30
A novel, helminth-derived immunostimulant enhances human recall responses to hepatitis C virus and tetanus toxoid and is dependent on CD56+ cells for its action. (18341617)
2008
31
A simple and rapid method for quantifying 2-phenoxyethanol (2-PE) in Diphtheria, Tetanus and w-Pertussis (DTwP) vaccine. (17728142)
2008
32
An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine and diphtheria and tetanus toxoids adsorbed combined with inactivated poliomyelitis vaccine. (17045366)
2007
33
The immunological response of Thai infants to haemophilus influenzae type B polysaccharide-tetanus conjugate vaccine co-administered in the same syringe with locally produced diphtheria-tetanus-pertussis vaccine. (17710973)
2007
34
Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy. (15717298)
2005
35
Human onchocerciasis and tetanus vaccination: impact on the postvaccination antitetanus antibody response. (10531253)
1999
36
Acute disseminated encephalomyelitis associated with tetanus vaccination. (10343155)
1999
37
A chronic focal epilepsy with mossy fiber sprouting follows recurrent seizures induced by intrahippocampal tetanus toxin injection in infant rats. (10392831)
1999
38
An anti-CD19 antibody coupled to a tetanus toxin peptide induces efficient Fas ligand (FasL)-mediated cytotoxicity of a transformed human B cell line by specific CD4+ T cells. (9822273)
1998
39
Tetanus as a cause of acute renal failure: possible role of rhabdomyolysis. (8115681)
1993
40
Isotype composition of antibodies to streptococcus group B type III polysaccharide and to tetanus toxoid in maternal, cord blood sera and in breast milk. (1537371)
1992
41
Traditional birth attendants in an endemic area of tetanus neonatorum in Thailand: pitfalls in the control program. (1774348)
1991
42
Role of intrathecal tetanus antitoxin (equine) in tetanus neonatorum. (2754273)
1989
43
Double-blind trial of intramuscular and intramuscular plus intrathecal human tetanus immunoglobulin and intramuscular equine tetanus antitoxin in the treatment of tetanus neonatorum. (3232228)
1988
44
Treatment of tetanus neonatorum in a rural setting. (6688850)
1983
45
Myositis ossificans localisata as a complication of tetanus. (525320)
1979
46
Cause of death in tetanus neonatorum: study of 233 cases with 54 necropsies. (879851)
1977
47
Experiences in the management of tetanus neonatorum with particular reference to the role of diazepam. (4839236)
1974
48
Treatment of tetanus neonatorum. (5335337)
1966
49
SOME MODIFICATIONS IN METHOD OF TREATING TETANUS NEONATORUM WITH INTERMITTENT POSITIVE-PRESSURE RESPIRATION. (14160093)
1964
50
Tetanus neonatorum treated with chlorpromazine, tetanus antiserum and penicillin. (13461072)
1957

Variations for Tetanus

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Expression for genes affiliated with Tetanus

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Search GEO for disease gene expression data for Tetanus.

Pathways for genes affiliated with Tetanus

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Compounds for genes affiliated with Tetanus

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Compounds related to Tetanus according to GeneCards Suite gene sharing:

(show all 23)
idCompoundScoreTop Affiliating Genes
1cardiolipin43 1211.0CD79A, MPZ
2gabapentin43 24 1211.9GABBR1, CACNA1B
3methacholine43 49 1211.9CD79A, IL9
4cnqx43 5910.9GABBR1, CACNA1B
5valproate439.9GABBR1, CD79A
6okt3439.7CD79A, HTLVR
7clonidine43 49 28 1212.7GABBR1, CACNA1B
8tarc439.7IL9, CCR7
9histamine43 28 2411.6CD79A, GABBR1, IL9
10allergens439.5IL9, CD79A
11gaba439.1GABBR1, CACNA1B, VAMP2
12norepinephrine43 24 1211.1CD79A, GABBR1, CACNA1B, CCR7
13nmda43 2810.0VAMP2, CACNA1B, GABBR1
14pge2439.0CD79A, CACNA1B, CCR7
15cysteine438.9MPZ, CACNA1B, GABBR1, CD27, CD79A
16acetylcholine43 49 28 24 1212.8VAMP2, CACNA1B, GABBR1, CD79A
17dopamine43 28 24 1211.7VAMP2, CACNA1B, GABBR1, CD79A
18hydrogen43 249.7VAMP2, VAMP3, CACNA1B
19lipid438.5IL9, CCR7, VAMP2, MPZ
20phosphatidylinositol438.4VAMP2, VAMP3, CCR7, CACNA1B
21glutamate438.4MPZ, VAMP2, CACNA1B, GABBR1, CD79A
22tyrosine438.3MPZ, VAMP2, CCR7, IL9, GABBR1
23calcium43 49 24 1211.0VAMP7, VAMP2, CCR7, CACNA1B, GABBR1, CD27

GO Terms for genes affiliated with Tetanus

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Cellular components related to Tetanus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.3CD79A, CD27, CCR7
2synaptic vesicleGO:00080219.1VAMP3, VAMP2
3clathrin-coated vesicleGO:00301369.0VAMP2, VAMP3
4SNARE complexGO:00312019.0VAMP3, VAMP2, VAMP7
5neuron projectionGO:00430058.9VAMP3, VAMP2, VAMP7
6cell junctionGO:00300548.6VAMP7, VAMP2, VAMP3, GABBR1
7integral component of plasma membraneGO:00058878.3CD27, GABBR1, VAMP2, MPZ
8plasma membraneGO:00058866.9MPZ, VAMP7, VAMP2, VAMP3, CCR7, CACNA1B

Biological processes related to Tetanus according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1Golgi to plasma membrane protein transportGO:00430019.7VAMP3, VAMP7
2exocytosisGO:00068879.7VAMP3, VAMP7
3positive regulation of JNK cascadeGO:00463309.4CD27, CCR7
4post-Golgi vesicle-mediated transportGO:00068929.3VAMP7, VAMP2
5calcium ion-dependent exocytosisGO:00171569.0VAMP3, VAMP2, VAMP7
6vesicle fusionGO:00069069.0VAMP7, VAMP2, VAMP3
7neurotransmitter secretionGO:00072698.8CACNA1B, VAMP3, VAMP2
8synaptic transmissionGO:00072688.5MPZ, VAMP2, CACNA1B, GABBR1

Molecular functions related to Tetanus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1syntaxin bindingGO:00199059.4VAMP2, VAMP7
2SNARE bindingGO:00001499.4VAMP3, VAMP7
3SNAP receptor activityGO:00054848.7VAMP3, VAMP2, VAMP7

Products for genes affiliated with Tetanus

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Sources for Tetanus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet