MCID: TTN003
MIFTS: 63

Tetanus malady

Neuronal diseases, Infectious diseases categories

Summaries for Tetanus

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Tetanus is a serious illness caused by clostridium bacteria. the bacteria live in soil, saliva, dust, and manure. the bacteria can enter the body through a deep cut, like those you might get from stepping on a nail, or through a burn. the infection causes painful tightening of the muscles, usually all over the body. it can lead to "locking" of the jaw. this makes it impossible to open your mouth or swallow. tetanus is a medical emergency. you need to get treatment in a hospital. a vaccine can prevent tetanus. it is given as a part of routine childhood immunization. adults should get a tetanus shot, or booster, every 10 years. if you get a bad cut or burn, see your doctor - you may need a booster. immediate and proper wound care can prevent tetanus infection.

MalaCards: Tetanus, also known as infection due to clostridium tetani, is related to tetanus neonatorum and influenza. An important gene associated with Tetanus is VAMP7 (vesicle-associated membrane protein 7), and among its related pathways are PEDF Induced Signaling and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The drugs chlorpromazine and chlorpromazine hydrochloride and the compounds calcium and lipid have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and skeletal muscle, and related mouse phenotypes are cellular and hematopoietic system.

Disease Ontology:8 A primary bacterial infectious disease that results in prolonged contraction of skeletal muscle fibers, has material basis in clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.

CDC:3 Tetanus is an infection caused by bacteria called Clostridium tetani. When the bacteria invade the body, they produce a poison (toxin) that causes painful muscle contractions. Another name for tetanus is "lockjaw" because it often causes a person's neck and jaw muscles to lock, making it hard to open the mouth or swallow. Vaccines are recommended for infants, children, teens and adults to prevent tetanus.

Wikipedia:63 Tetanus (from Ancient more...

Aliases & Classifications for Tetanus

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

tetanus 8 42 10 44 48 33 60
infection due to clostridium tetani 8
clostridial tetanus 8
lockjaw 42


External Ids:

Disease Ontology8 DOID:11338
MeSH34 D013742
NCIt39 C85185
ICD9CM27 037
SNOMED-CT via Orphanet57 76902006, 276202003
UMLS via Orphanet61 C0039614
MESH via Orphanet35 D013742
ICD10 via Orphanet26 A33, A34, A35

Related Diseases for Tetanus

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tetanus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1tetanus neonatorum31.3MNT, ACE2
2influenza31.2PMEL, CCR7, CD69, CD27
3arthritis30.2CCR7, CD69
4multiple sclerosis29.9CCR7, CSN2, HTLVR, CD69, CD27, IL9
5leukemia29.7CCR7, HTLVR, FLT3LG, CD27, IL9
6melanoma29.7PMEL, CCR7, FLT3LG, MPP1, CD27
7sarcoidosis29.7IL9, CD27, CD69
8diphtheria11.1
9pertussis11.0
10hepatitis10.7
11hepatitis b10.7
12poliomyelitis10.6
13hepatitis a10.6
14neuronitis10.5
15measles10.4
16rubella10.3
17myositis ossificans10.3
18mumps10.3
19myositis10.3
20hepatitis c10.2
21gas gangrene10.2
22focal epilepsy10.2
23leprosy10.2
24myelitis10.1
25lepromatous leprosy10.1
26rabies10.1
27onchocerciasis10.1
28reactive arthritis10.1
29botulism10.1
30malaria10.1
31noma10.0
32ipex syndrome10.0CCR7, CSN2, FLT3LG, MPP1, CD69, CD27
33hypersensitivity reaction type ii disease10.0PMEL, CCR7, CSN2, HTLVR, CD69, IL9
34non-hodgkin lymphoma10.0CCR7, FLT3LG, CD27, IL9
35malignant glioma10.0PMEL, CACNA1B, STX1A, FLT3LG, CD27
36immunodeficiency with hyper igm type 210.0CD69, CSN2, CCR7, PVALB
37myeloid leukemia10.0IL9
38insulinoma10.0VAMP2
39graves' disease10.0CD69, HTLVR
40human immunodeficiency virus infectious disease10.0CD27, CD69
41b-cell chronic lymphocytic leukemia10.0CCR7, CD69, CD27
42burkitt's lymphoma10.0IL9, CD27, CD69, MPP1, CCR7
43common variable immune deficiency10.0CD27
44type 1 diabetes10.0CD69, HTLVR, CSN2
45tuberculosis10.0VAMP3, CD69, MPP1, CCR7
46antiphospholipid syndrome10.0
47temporal lobe epilepsy10.0
48systemic lupus erythematosus10.0
49acute disseminated encephalomyelitis10.0
50complex regional pain syndrome10.0

Graphical network of the top 20 diseases related to Tetanus:



Diseases related to tetanus

Clinical Features for Tetanus

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Drugs & Therapeutics for Tetanus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Tetanus

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Anatomical Context for Tetanus

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32MalaCards
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MalaCards organs/tissues related to Tetanus:

32
Spinal cord, Brain, Skeletal muscle, T cells, Testes, B cells, Heart, Breast, Cortex, Temporal lobe, Kidney, Monocytes, Tongue

Animal Models for Tetanus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tetanus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538410.7ACE2, RIPK4, CD69, MNT, MPP1, FLT3LG
2MP:000539710.6PMEL, IL9, RIPK4, VAMP2, VAMP3, CD27
3MP:000538710.4CCR7, FLT3LG, MPP1, CD69, CD27, VAMP3

Publications for Tetanus

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Sources:
50PubMed
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Articles related to Tetanus:

(show top 50)    (show all 884)
idTitleAuthorsYear
1
Complex regional pain syndrome type I following tetanus toxoid injection. (24356477)
2014
2
Tetanus is still a deadly disease: a report of six tetanus cases and reminder of our knowledge. (24301382)
2014
3
Persistence of antibodies for 42 months following vaccination of adolescents with a meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine (MenACWY-TT). (23246368)
2013
4
Causality of rhabdomyolysis and combined tetanus, diphtheria and acellular pertussis (Tdap) vaccine administration. (23913623)
2013
5
Binding and cleavage (BINACLE) assay for the functional in vitro detection of tetanus toxin: Applicability as alternative method for the safety testing of tetanus toxoids during vaccine production. (24156922)
2013
6
Association between undervaccination with diphtheria, tetanus toxoids, and acellular pertussis (DTaP) vaccine and risk of pertussis infection in children 3 to 36 months of age. (24019039)
2013
7
Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant women--Advisory Committee on Immunization Practices (ACIP), 2012. (23425962)
2013
8
Meningococcal polysaccharide A O-acetylation levels do not impact the immunogenicity of the quadrivalent meningococcal tetanus toxoid conjugate vaccine: results from a randomized, controlled phase III study of healthy adults aged 18 to 25 years. (23885033)
2013
9
The ocular conjunctiva as a mucosal immunization route: a profile of the immune response to the model antigen tetanus toxoid. (23637758)
2013
10
Effect of Spirulina (Arthrospira) supplementation on the immune response to tetanus toxoid vaccination in a mouse model. (23927690)
2013
11
Evaluation of TLR agonists as potential mucosal adjuvants for HIV gp140 and tetanus toxoid in mice. (23272062)
2012
12
Tetanus--a case report with severe autonomic instability and: a review of the literature. (23304936)
2012
13
Tetanus in adults: clinical presentation, treatment and predictors of mortality in a tertiary hospital in Ethiopia. (22425013)
2012
14
Tetanus following tongue bite from repeated convulsions: a case report. (22678074)
2012
15
Intrathecal anti-tetanus human immunoglobulin in the treatment of neonatal tetanus. (21914410)
2011
16
The evaluation of Tetanus-diphtheria (Td) vaccine impacts on immune response to hepatitis B (HB) vaccine in non-responder dialysis patients. (22091281)
2011
17
Infant pertussis epidemiology and implications for tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccination: King County, Washington, 2002 through 2007. (21727277)
2011
18
Preparation of tetanus toxoid and ovalbumin loaded gliadin nanoparticles for oral immunization. (21485875)
2011
19
Persistence of antibodies 3 years after booster vaccination of adults with combined acellular pertussis, diphtheria and tetanus toxoids vaccine. (21945698)
2011
20
Prevalence and outcome of neonatal tetanus in Zaria, Northwestern Nigeria. (21537066)
2011
21
In vitro determination of tetanus toxicity by an endopeptidase assay linked to a ganglioside-binding step. (20036726)
2010
22
Combined Haemophilus influenzae type b and Neisseria meningitidis serogroup C (HibMenC) or serogroup C and Y-tetanus toxoid conjugate (and HibMenCY) vaccines are well-tolerated and immunogenic when administered according to the 2,3,4 months schedule with a fourth dose at 12-18 months of age. (20697200)
2010
23
Evaluation of an acellular pertussis, diphtheria, tetanus, inactivated poliovirus, Hib-conjugate combined vaccine (Pentaxim) at 2, 4, and 6 months of age plus hepatitis B vaccine at birth, 2, and 6 months of age in infants in Thailand. (20578530)
2010
24
Serum titers of IgG antibodies against tetanus and diphtheria toxoids and risk of multiple sclerosis. (19201486)
2009
25
Booster vaccination of toddlers with reduced antigen content diphtheria -- tetanus -- acellular pertussis vaccine. (19368781)
2009
26
Efficacy of diphtheria and tetanus vaccination in Gaza, Palestine. (19554974)
2009
27
A simple and rapid method for quantifying 2-phenoxyethanol (2-PE) in Diphtheria, Tetanus and w-Pertussis (DTwP) vaccine. (17728142)
2008
28
Absence of an increase in cardiorespiratory events after diphtheria-tetanus-acellular pertussis immunization in preterm infants: a randomized, multicenter study. (18450851)
2008
29
No increase in cardiorespiratory events seen after diphtheria-tetanus-acellular pertussis immunization. (18940365)
2008
30
Men with low vitamin A stores respond adequately to primary yellow fever and secondary tetanus toxoid vaccination. (18936231)
2008
31
A population-based, postlicensure evaluation of the safety of a combination diphtheria, tetanus, acellular pertussis, hepatitis B, and inactivated poliovirus vaccine in a large managed care organization. (19047220)
2008
32
Calibration of replacement international standards of diphtheria and tetanus toxoids for use in flocculation test. (18676158)
2008
33
Safety of the 11-valent pneumococcal vaccine conjugated to non-typeable Haemophilus influenzae-derived protein D in the first 2 years of life and immunogenicity of the co-administered hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated polio virus, Haemophilus influenzae type b and control hepatitis A vaccines. (18602724)
2008
34
Measuring immunoglobulin g antibodies to tetanus toxin, diphtheria toxin, and pertussis toxin with single-antigen enzyme-linked immunosorbent assays and a bead-based multiplex assay. (18321880)
2008
35
Immunogenicity of a triple diphtheria-tetanus-whole cell pertussis vaccine in Iranian preschool children. (17652850)
2007
36
Environmentally and occupationally acquired diseases in adolescents and adulthood: control of diphtheria, tetanus, pertussis, and poliomyelitis through regular booster vaccinations--a European perspective. (16422349)
2005
37
Serotonin transport is modulated differently by tetanus toxin and growth factors. (12590935)
2003
38
A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. (9614185)
1998
39
Expression of SNARE proteins in enteroendocrine cell lines and functional role of tetanus toxin-sensitive proteins in cholecystokinin release. (9541008)
1998
40
Cytokine synthesis analyzed at the single-cell level before and after revaccination with tetanus toxoid. (8056039)
1994
41
Cephalic tetanus presenting with incomplete Bell's palsy. (8056552)
1994
42
A case of maple syrup urine disease misdiagnosed as tetanus neonatorum on admission. (8091979)
1994
43
Pyridoxine therapy in tetanus neonatorum. (6676307)
1983
44
Tetanus neonatorum: A continuing problem. (7239676)
1980
45
Cranial nerve palsy in tetanus. (4692727)
1973
46
Gas gangrene with tetanus. (5057281)
1972
47
Valium on the treatment of tetanus neonatorum. (4647889)
1972
48
"Locked-in syndrome" from diazepam toxicity in a patient with tetanus. (4108939)
1972
49
The place of tracheostomy in tetanus neonatorum. (4862969)
1967
50
Fatal tetanus associated with acute maxillary sinusitis. (20998763)
1946

Genetic Variations for Tetanus

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Expression for genes affiliated with Tetanus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tetanus

Search GEO for disease gene expression data for Tetanus.

Pathways for genes affiliated with Tetanus

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51QIAGEN, 29KEGG, 49PharmGKB, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Tetanus

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Tetanus according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.1VTI1B, PVALB, CCR7, CACNA1B, CSN2, STX1A
2lipid4410.9CCR7, CSN2, STX1A, MPP1, CD69, VAMP2
3tyrosine4410.9PVALB, CCR7, CSN2, FLT3LG, MPP1, CD69
4phosphatidylinositol4410.9CCR7, CACNA1B, CSN2, CD69, VAMP3, VAMP2
5allergens4410.8PVALB, CSN2, CD69, IL9
6glutamate4410.8PVALB, CACNA1B, CSN2, STX1A, MPP2, VAMP2
7chloride4410.8PVALB, STX1A, IL9, ACE2
8cysteine4410.8VTI1B, CD27, MPP2, STX1A, CSN2, CACNA1B
9gaba4410.7PVALB, CACNA1B, STX1A, VAMP2
10glucose4410.6VTI1B, VAMP2, VAMP3, MPP2, MPP1, STX1A
11n-ethylmaleimide44 1111.6VAMP3, VAMP2, VTI1B
12h2o4410.5CSN2, PVALB
13latex4410.5PVALB, CCR7, CSN2
14serine4410.3IL9, RIPK4, VAMP2, CD69, CSN2, PVALB

GO Terms for genes affiliated with Tetanus

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16Gene Ontology
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Cellular components related to Tetanus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SNARE complexGO:03120110.7VAMP7, VAMP2, VTI1B, STX1A, VAMP3
2neuron projectionGO:04300510.7VAMP3, STX1A, VAMP2, VAMP7
3membraneGO:01602010.6VAMP2, MPP2, MPP1, FLT3LG, RIPK4
4synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complexGO:07003210.5VAMP2, STX1A
5synaptobrevin 2-SNAP-25-syntaxin-1a complexGO:07004410.4VAMP2, STX1A
6cell junctionGO:03005410.3STX1A, VAMP3, VAMP7, VAMP2

Biological processes related to Tetanus according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1calcium ion-dependent exocytosisGO:01715610.8VAMP2, VAMP7, VAMP3, STX1A
2Golgi to plasma membrane protein transportGO:04300110.7VAMP3, VAMP7, VAMP2
3neurotransmitter secretionGO:00726910.7VAMP2, STX1A, CACNA1B
4autophagic vacuole fusionGO:00004610.6VAMP7, VTI1B
5glutamate secretionGO:01404710.5VAMP2, STX1A
6membrane fusionGO:06102510.5VTI1B, VAMP3
7vesicle-mediated transportGO:01619210.5VAMP3, VAMP7, VTI1B
8vesicle docking involved in exocytosisGO:00690410.2VTI1B, VAMP3

Molecular functions related to Tetanus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1syntaxin-1 bindingGO:01707510.5VAMP2, VAMP3
2guanylate kinase activityGO:00438510.2MPP2, MPP1

Products for genes affiliated with Tetanus

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  • Antibodies
  • Proteins
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Sources for Tetanus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet