MCID: TTN003
MIFTS: 63

Tetanus malady

Neuronal diseases, Infectious diseases categories

Summaries for Tetanus

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Tetanus is a serious illness caused by clostridium bacteria. the bacteria live in soil, saliva, dust, and manure. the bacteria can enter the body through a deep cut, like those you might get from stepping on a nail, or through a burn. the infection causes painful tightening of the muscles, usually all over the body. it can lead to "locking" of the jaw. this makes it impossible to open your mouth or swallow. tetanus is a medical emergency. you need to get treatment in a hospital. a vaccine can prevent tetanus. it is given as a part of routine childhood immunization. adults should get a tetanus shot, or booster, every 10 years. if you get a bad cut or burn, see your doctor - you may need a booster. immediate and proper wound care can prevent tetanus infection.

MalaCards: Tetanus, also known as infection due to clostridium tetani, is related to tetanus neonatorum and influenza. An important gene associated with Tetanus is VAMP7 (vesicle-associated membrane protein 7), and among its related pathways are PEDF Induced Signaling and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The drugs chlorpromazine and chlorpromazine hydrochloride and the compounds calcium and lipid have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and skeletal muscle, and related mouse phenotypes are cellular and hematopoietic system.

Disease Ontology:8 A primary bacterial infectious disease that results in prolonged contraction of skeletal muscle fibers, has material basis in clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.

CDC:3 Tetanus is an infection caused by bacteria called Clostridium tetani. When the bacteria invade the body, they produce a poison (toxin) that causes painful muscle contractions. Another name for tetanus is "lockjaw" because it often causes a person's neck and jaw muscles to lock, making it hard to open the mouth or swallow. Vaccines are recommended for infants, children, teens and adults to prevent tetanus.

Wikipedia:63 Tetanus (from Ancient more...

Aliases & Classifications for Tetanus

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

tetanus 8 42 10 44 48 33 60
infection due to clostridium tetani 8
clostridial tetanus 8
lockjaw 42


External Ids:

Disease Ontology8 DOID:11338
MeSH34 D013742
NCIt39 C85185
ICD9CM27 037
SNOMED-CT via Orphanet57 76902006, 276202003
UMLS via Orphanet61 C0039614
MESH via Orphanet35 D013742
ICD10 via Orphanet26 A33, A34, A35

Related Diseases for Tetanus

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tetanus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1tetanus neonatorum31.3MNT, ACE2
2influenza31.2PMEL, CCR7, CD69, CD27
3arthritis30.2CCR7, CD69
4multiple sclerosis29.9CCR7, CSN2, HTLVR, CD69, CD27, IL9
5leukemia29.7CCR7, HTLVR, FLT3LG, CD27, IL9
6melanoma29.7PMEL, CCR7, FLT3LG, MPP1, CD27
7sarcoidosis29.7IL9, CD27, CD69
8diphtheria11.1
9pertussis11.0
10hepatitis10.7
11hepatitis b10.7
12poliomyelitis10.6
13hepatitis a10.6
14neuronitis10.5
15measles10.4
16rubella10.3
17myositis ossificans10.3
18mumps10.3
19myositis10.3
20hepatitis c10.2
21gas gangrene10.2
22focal epilepsy10.2
23leprosy10.2
24myelitis10.1
25lepromatous leprosy10.1
26rabies10.1
27onchocerciasis10.1
28reactive arthritis10.1
29botulism10.1
30malaria10.1
31noma10.0
32ipex syndrome10.0CCR7, CSN2, FLT3LG, MPP1, CD69, CD27
33hypersensitivity reaction type ii disease10.0PMEL, CCR7, CSN2, HTLVR, CD69, IL9
34non-hodgkin lymphoma10.0CCR7, FLT3LG, CD27, IL9
35malignant glioma10.0PMEL, CACNA1B, STX1A, FLT3LG, CD27
36immunodeficiency with hyper igm type 210.0CD69, CSN2, CCR7, PVALB
37myeloid leukemia10.0IL9
38insulinoma10.0VAMP2
39graves' disease10.0CD69, HTLVR
40human immunodeficiency virus infectious disease10.0CD27, CD69
41b-cell chronic lymphocytic leukemia10.0CCR7, CD69, CD27
42burkitt's lymphoma10.0IL9, CD27, CD69, MPP1, CCR7
43common variable immune deficiency10.0CD27
44type 1 diabetes10.0CD69, HTLVR, CSN2
45tuberculosis10.0VAMP3, CD69, MPP1, CCR7
46antiphospholipid syndrome10.0
47temporal lobe epilepsy10.0
48systemic lupus erythematosus10.0
49acute disseminated encephalomyelitis10.0
50complex regional pain syndrome10.0

Graphical network of the top 20 diseases related to Tetanus:



Diseases related to tetanus

Clinical Features for Tetanus

About this section

Drugs & Therapeutics for Tetanus

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Genetic Tests for Tetanus

About this section

Anatomical Context for Tetanus

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Tetanus:

32
Spinal cord, Brain, Skeletal muscle, T cells, Testes, B cells, Temporal lobe, Breast, Heart, Cortex, Monocytes, Kidney, Tongue

Animal Models for Tetanus or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Tetanus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538410.7CCR7, FLT3LG, MPP1, MNT, CD69, RIPK4
2MP:000539710.6IL9, PMEL, CCR7, FLT3LG, CD69, CD27
3MP:000538710.4CCR7, FLT3LG, MPP1, CD69, CD27, VAMP3

Publications for Tetanus

About this section
Sources:
50PubMed
See all sources

Articles related to Tetanus:

(show top 50)    (show all 884)
idTitleAuthorsYear
1
Predictors of tetanus-diphtheria- acellular pertussis vaccination among adults receiving tetanus vaccine in the United States: data from the 2008 national health interview survey. (23799715)
2013
2
Prognosis of tetanus patients in the intensive care unit of Provincial Hospital Jason Sendwe, Lubumbashi, DR Congo. (23717709)
2013
3
Entry of a recombinant full-length, atoxic tetanus neurotoxin into Neuro-2a cells. (24324184)
2013
4
Physicochemical and immunochemical assays for monitoring consistent production of tetanus toxoid. (23726755)
2013
5
Validation of maternal and neonatal tetanus elimination in United Republic of Tanzania, 2012. (23980289)
2013
6
Effective humoral immunity against diphtheria and tetanus in patients with systemic lupus erythematosus or myasthenia gravis. (23454161)
2013
7
One or two doses of quadrivalent meningococcal serogroups A, C, W-135 and Y tetanus toxoid conjugate vaccine is immunogenic in 9- to 12-month-old children. (23348814)
2013
8
Improved stability and immunological potential of tetanus toxoid containing surface engineered bilosomes following oral administration. (24036099)
2013
9
Meningococcal quadrivalent (serogroups A, C, W135 and Y) tetanus toxoid conjugate vaccine (Nimenrixa8c). (23231026)
2012
10
Mucosal Adjuvant Potential of Quillaja saponins and Cross-linked Dextran Microspheres, Co-administered with Liposomes Encapsulated with Tetanus Toxoid. (24250499)
2012
11
Sublingual immunization with an engineered Bacillus subtilis strain expressing tetanus toxin fragment C induces systemic and mucosal immune responses in piglets. (22198093)
2012
12
Changes in antigen-specific IgG1 Fc N-glycosylation upon influenza and tetanus vaccination. (22184099)
2012
13
Trends in neonatal and post-neonatal tetanus admissions at a Nigerian teaching hospital. (23276738)
2012
14
Influences on formation of tetanus antibody after simultaneous injection of tetanus immunoglobulin with tetanus vaccine. (22876062)
2012
15
Safety and immunogenicity of 2 mixed primary infant immunization schedules of pentavalent diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis, and Haemophilus influenzae Type B vaccines at 2, 4, and 6 months of age: a randomized controlled trial. (22173143)
2012
16
Assessment of a mandatory tetanus, diphtheria, and pertussis vaccination requirement on vaccine uptake over time. (22173527)
2012
17
Adverse events after tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine administered to adults 65 years of age and older reported to the Vaccine Adverse Event Reporting System (VAERS), 2005-2010. (21920404)
2011
18
Validation of elimination: maternal and neonatal tetanus a89 Uganda, 2011. (22180897)
2011
19
Immunogenicity and safety of a combined diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine (DTaP-IPV) compared to separate administration of standalone DTaP and IPV vaccines: a randomized, controlled study in infants in the Republic of Korea. (21215828)
2011
20
SV2 mediates entry of tetanus neurotoxin into central neurons. (21124874)
2010
21
High tetanus antitoxin antibody concentrations in the Netherlands: a seroepidemiological study. (20875496)
2010
22
Immunogenicity and safety of diphtheria-tetanus vaccine in adults. (21165286)
2010
23
Immunogenicity of a heptavalent conjugate pneumococcal vaccine administered concurrently with a combination diphtheria, tetanus, five-component acellular pertussis, inactivated polio, and Haemophilus influenzae type B vaccine and a meningococcal group C conjugate vaccine at 2, 3, and 4 months of age. (20042517)
2010
24
Effectiveness of adolescent and adult tetanus, reduced-dose diphtheria, and acellular pertussis vaccine against pertussis. (20578875)
2010
25
Tdap5 vaccine (Covaxis): a review of its use as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis in children (aged 4 years), adolescents, and adults. (21043546)
2010
26
An assessment of the safety of adolescent and adult tetanus-diphtheria-acellular pertussis (Tdap) vaccine, using active surveillance for adverse events in the Vaccine Safety Datalink. (19486957)
2009
27
Serological immunity to diphtheria and tetanus in healthy adults in Delhi, India. (19535754)
2009
28
Safety and immunogenicity of diphtheria-tetanus-pertussis vaccine and hepatitis B vaccine as a new tetravalent combination (DTwP/HB) administered alone and at separate sites (DTwP and HB) including comparison with standard commercially available combination vaccine in Indian infants 6-14 weeks of age. (18849664)
2009
29
Poor immune responses to a birth dose of diphtheria, tetanus, and acellular pertussis vaccine. (18534242)
2008
30
Are we progressing towards elimination of diphtheria, pertussis, tetanus from Nepal? (19483439)
2008
31
Diphtheria, pertussis, and tetanus serosurvey in Saudi children. (17676208)
2007
32
Quality of the Haemophilus influenzae type b (Hib) antibody response induced by diphtheria-tetanus-acellular pertussis/Hib combination vaccines. (17699836)
2007
33
Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy. (15717299)
2005
34
Antibody persistence against diphtheria, tetanus, pertussis, poliomyelitis and Haemophilus influenzae type b (Hib) in 5-6-year-old children after primary vaccination and first booster with a pentavalent combined acellular pertussis vaccine: immunogenicity and tolerance of a tetravalent combined acellular pertussis vaccine given as a second booster. (15063564)
2004
35
Severe autonomic dysfunction in an 11-year-old girl with generalised tetanus. (12939708)
2003
36
Recurrence of reactive arthritis after a booster dose of tetanus toxoid. (11796415)
2002
37
Differential and time-dependent changes in gene expression for type II calcium/calmodulin-dependent protein kinase, 67 kDa glutamic acid decarboxylase, and glutamate receptor subunits in tetanus toxin-induced focal epilepsy. (9045741)
1997
38
Natural processing sites for human cathepsin E and cathepsin D in tetanus toxin: implications for T cell epitope generation. (9366392)
1997
39
Brown-SAcquard syndrome following diphtheria and tetanus vaccines. (8009620)
1994
40
Acute transverse myelitis after tetanus toxoid vaccination. (1349123)
1992
41
Effects of tetanus toxin, Salmonella typhimurium porin, and bacterial lipopolysaccharide on platelet aggregation. (1335019)
1992
42
Traditional birth attendants in an endemic area of tetanus neonatorum in Thailand: pitfalls in the control program. (1774348)
1991
43
A new method of grading tetanus neonatorum. (6803003)
1982
44
A study of tetanus neonatorum with special reference to effects of corticosteroid therapy. (4781020)
1973
45
Case study: tetanus neonatorum. (5201769)
1970
46
THE TREATMENT OF TETANUS NEONATORUM. (14254339)
1964
47
TREATMENT OF TETANUS NEONATORUM. APPROACH TO THERAPY IN 800 CASES. (14180444)
1964
48
Management of Tetanus Neonatorum with Intermittent Positive-pressure Respiration. (21032414)
1963
49
Myositis ossificans as a complication of tetanus. (13851828)
1959
50
A Case of Tetanus Neonatorum Unsuccessfully Treated with Tetanus Antitoxin. (20755275)
1895

Genetic Variations for Tetanus

About this section

Expression for genes affiliated with Tetanus

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tetanus

Search GEO for disease gene expression data for Tetanus.

Pathways for genes affiliated with Tetanus

About this section
Sources:
51QIAGEN, 29KEGG, 49PharmGKB, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome
See all sources

Compounds for genes affiliated with Tetanus

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Tetanus according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.1VTI1B, PVALB, CCR7, CACNA1B, CSN2, STX1A
2lipid4410.9CCR7, CSN2, STX1A, MPP1, CD69, VAMP2
3tyrosine4410.9PVALB, CCR7, CSN2, FLT3LG, MPP1, CD69
4phosphatidylinositol4410.9CCR7, CACNA1B, CSN2, CD69, VAMP3, VAMP2
5allergens4410.8PVALB, CSN2, CD69, IL9
6glutamate4410.8PVALB, CACNA1B, CSN2, STX1A, MPP2, VAMP2
7chloride4410.8PVALB, STX1A, IL9, ACE2
8cysteine4410.8VTI1B, CD27, MPP2, STX1A, CSN2, CACNA1B
9gaba4410.7PVALB, CACNA1B, STX1A, VAMP2
10glucose4410.6VTI1B, VAMP2, VAMP3, MPP2, MPP1, STX1A
11n-ethylmaleimide44 1111.6VAMP3, VAMP2, VTI1B
12h2o4410.5CSN2, PVALB
13latex4410.5PVALB, CCR7, CSN2
14serine4410.3IL9, RIPK4, VAMP2, CD69, CSN2, PVALB

GO Terms for genes affiliated with Tetanus

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Tetanus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SNARE complexGO:03120110.7VTI1B, VAMP2, VAMP7, VAMP3, STX1A
2neuron projectionGO:04300510.7STX1A, VAMP3, VAMP7, VAMP2
3membraneGO:01602010.6RIPK4, VAMP2, MPP2, MPP1, FLT3LG
4synaptobrevin 2-SNAP-25-syntaxin-1a complexGO:07004410.5STX1A, VAMP2
5synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complexGO:07003210.4STX1A, VAMP2
6cell junctionGO:03005410.3STX1A, VAMP3, VAMP7, VAMP2

Biological processes related to Tetanus according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1calcium ion-dependent exocytosisGO:01715610.8VAMP2, VAMP7, VAMP3, STX1A
2Golgi to plasma membrane protein transportGO:04300110.7VAMP3, VAMP7, VAMP2
3neurotransmitter secretionGO:00726910.7VAMP2, STX1A, CACNA1B
4autophagic vacuole fusionGO:00004610.6VAMP7, VTI1B
5glutamate secretionGO:01404710.5VAMP2, STX1A
6membrane fusionGO:06102510.5VTI1B, VAMP3
7vesicle-mediated transportGO:01619210.5VAMP3, VAMP7, VTI1B
8vesicle docking involved in exocytosisGO:00690410.2VTI1B, VAMP3

Molecular functions related to Tetanus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1syntaxin-1 bindingGO:01707510.5VAMP2, VAMP3
2guanylate kinase activityGO:00438510.2MPP2, MPP1

Products for genes affiliated with Tetanus

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tetanus

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet