Tethered Spinal Cord Syndrome malady

Categories: Neuronal diseases

Aliases & Classifications for Tethered Spinal Cord Syndrome

Aliases & Descriptions for Tethered Spinal Cord Syndrome:

Name: Tethered Spinal Cord Syndrome 12 51 14
Spinal Dysraphism 12 29 42


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Disease Ontology 12 DOID:1089
ICD10 33 Q05 Q05.9
ICD9CM 35 741
MeSH 42 D016135
NCIt 47 C101214
UMLS 69 C0080178

Summaries for Tethered Spinal Cord Syndrome

NINDS : 51 Tethered spinal cord syndrome is a neurological disorder caused by tissue attachments that limit the movement of the spinal cord within the spinal column.  Attachments may occur congenitally at the base of the spinal cord (conus medullaris) or they may develop near the site of an injury to the spinal cord.  These attachments cause an abnormal stretching of the spinal cord.  The course of the disorder is progressive.  In children, symptoms may include lesions, hairy patches, dimples, or fatty tumors on the lower back; foot and spinal deformities; weakness in the legs; low back pain; scoliosis; and incontinence.  This type of tethered spinal cord syndrome appears to be the result of improper growth of the neural tube during fetal development, and is closely linked to spina bifida.  Tethered spinal cord syndrome may go undiagnosed until adulthood, when pain, sensory and motor problems, and loss of bowel and bladder control emerge.  This delayed presentation of symptoms is related to the degree of strain placed on the spinal cord over time and may be exacerbated during sports or pregnancy, or may be due to narrowing of the spinal column (stenosis) with age. Tethering may also develop after spinal cord injury and scar tissue can block the flow of fluids around the spinal cord.  Fluid pressure may cause cysts to form in the spinal cord, a condition called syringomyelia.  This can lead to additional loss of movement, feeling or the onset of pain or autonomic symptoms.

MalaCards based summary : Tethered Spinal Cord Syndrome, also known as spinal dysraphism, is related to tethered cord syndrome and primary tethered cord syndrome. An important gene associated with Tethered Spinal Cord Syndrome is MNX1 (Motor Neuron And Pancreas Homeobox 1). The drugs Acetylcholine and Oxybutynin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related phenotypes are cellular and nervous system

Wikipedia : 71 Tethered cord syndrome (TCS) or occult spinal dysraphism sequence refers to a group of neurological... more...

Related Diseases for Tethered Spinal Cord Syndrome

Diseases related to Tethered Spinal Cord Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 tethered cord syndrome 11.1
2 primary tethered cord syndrome 11.1
3 dressler's syndrome 10.0 KIDINS220 MNX1
4 myelomeningocele 9.9
5 lipoma 9.8
6 diastematomyelia 9.8
7 neurogenic bladder 9.8
8 tooth disease 8.9 HOXA1 KIDINS220 MNX1 NKX2-8 SRCAP TCOF1

Graphical network of the top 20 diseases related to Tethered Spinal Cord Syndrome:

Diseases related to Tethered Spinal Cord Syndrome

Symptoms & Phenotypes for Tethered Spinal Cord Syndrome

MGI Mouse Phenotypes related to Tethered Spinal Cord Syndrome:

id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.55 HOXA1 KIDINS220 MNX1 NKX2-8 TCOF1
2 nervous system MP:0003631 9.35 TCOF1 HOXA1 KIDINS220 MNX1 NKX2-8
3 respiratory system MP:0005388 8.92 HOXA1 MNX1 NKX2-8 TCOF1

Drugs & Therapeutics for Tethered Spinal Cord Syndrome

Drugs for Tethered Spinal Cord Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 144)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Acetylcholine Approved Phase 4,Phase 3 51-84-3 187
Oxybutynin Approved, Investigational Phase 4,Phase 3 5633-20-5 4634
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
4 abobotulinumtoxinA Phase 4,Phase 3
5 Botulinum Toxins Phase 4,Phase 3
6 Botulinum Toxins, Type A Phase 4,Phase 3
7 Cholinergic Agents Phase 4,Phase 3
8 incobotulinumtoxinA Phase 4,Phase 3
9 Neuromuscular Agents Phase 4,Phase 3
10 Neurotransmitter Agents Phase 4,Phase 3
11 onabotulinumtoxinA Phase 4,Phase 3
12 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
13 Anti-Infective Agents Phase 4,Phase 3,Phase 2
14 Autonomic Agents Phase 4,Phase 3
15 Cholinergic Antagonists Phase 4,Phase 3
16 Mandelic Acids Phase 4,Phase 3
17 Muscarinic Antagonists Phase 4,Phase 3
18 Parasympatholytics Phase 4,Phase 3
19 Renal Agents Phase 4,Phase 3
20 Anti-Infective Agents, Local Phase 4
21 Chlorhexidine gluconate Phase 4
22 Dermatologic Agents Phase 4,Phase 3,Phase 2
23 Disinfectants Phase 4
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757 53477783
Drospirenone Approved Phase 3 67392-87-4 68873
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
Hydroxocobalamin Approved Phase 3 13422-51-0 11953898 5460373 44475014
Copper Approved Phase 3 15158-11-9, 7440-50-8 27099
Iron Approved Phase 3 7439-89-6 23925
Selenium Approved, Vet_approved Phase 3 7782-49-2
Zinc Approved Phase 3 7440-66-6 32051 23994
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1 59-30-3 6037
leucovorin Approved, Nutraceutical Phase 3,Phase 1 58-05-9 54575, 6560146 143
Cyanocobalamin Approved, Nutraceutical Phase 3 68-19-9 44176380
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
Nicotinamide Approved, Nutraceutical Phase 3 98-92-0 936
Pyridoxal Approved, Nutraceutical Phase 3 66-72-8 1050
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 3 65-23-6 1054
Riboflavin Approved, Nutraceutical, Vet_approved Phase 3 83-88-5 493570
Thiamine Approved, Nutraceutical, Vet_approved Phase 3 59-43-8 1130
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
44 Hematinics Phase 3,Phase 1
45 Micronutrients Phase 3,Phase 1
46 Trace Elements Phase 3,Phase 1
47 Vitamin B Complex Phase 3,Phase 1
48 Vitamins Phase 3,Phase 1
49 diuretics Phase 3,Phase 2
50 Estradiol 17 beta-cypionate Phase 3

Interventional clinical trials:

(show top 50) (show all 111)
id Name Status NCT ID Phase
1 Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele Unknown status NCT00175123 Phase 4
2 Safety and Efficacy Study of Transdermal Oxybutynin to Treat Overactive Bladder With a Neurological Condition Completed NCT00224016 Phase 4
3 Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch Completed NCT01411891 Phase 4
4 Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions Completed NCT01208584 Phase 4
5 Folic Acid Dosage and Malformations Reduction Unknown status NCT01244347 Phase 3
6 Efficacy and Safety Study for an Oral Contraceptive Containing Folate Completed NCT00468481 Phase 3
7 Botox Versus Oxybutynin as First Line Treatment for the Poorly Compliant Pediatric Neurogenic Bladder Completed NCT01716624 Phase 3
8 A Clinical Study to Investigate How Solifenacin Fluid is Taken up, How Long it Stays in the Body and How Effective and Safe it is in Treating Children Aged From 6 Months to Less Than 5 Years With Symptoms of Neurogenic Detrusor Overactivity (NDO) Completed NCT01981954 Phase 3
9 A Study to Assess the Long Term Effect, Safety and Metabolism of a Solifenacin Liquid Suspension in Patients 5 to 18 Years of Age With Neurogenic Detrusor Overactivity Completed NCT01565694 Phase 3
10 Study of Treatment With the Combination of Drospirenone Plus Ethinyl Estradiol Plus Levomefolate Calcium in Mexican Women Seeking Contraception Completed NCT01902264 Phase 3
11 Duragen Versus Duraguard in Chiari Surgery Completed NCT00741858 Phase 3
12 Children Toxine Botulinum Detrusor Injection in Neurogenic Vesical Hyperactivity Syndrom: Non Inferiority Multicenter Controlled Therapeutic Study Between Two Reported Weight's Doses Recruiting NCT02816151 Phase 3
13 Randomized Controlled Trial of Shunt vs ETV/CPC for PIH in Ugandan Infants Active, not recruiting NCT01936272 Phase 3
14 Impact of Pre-pregnancy Micronutrient Supplementation on Maternal and Child Outcomes Active, not recruiting NCT01665378 Phase 3
15 A Study to Evaluate Folate Levels in Women Taking Oral Contraceptives Withdrawn NCT00301587 Phase 3
16 Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence Unknown status NCT01867268 Phase 2
17 Lumbar to Sacral Ventral Nerve Re-Routing Completed NCT00378664 Phase 2
18 Coping Skills Training (CST) for Children With Chronic Health Conditions Completed NCT00359775 Phase 2
19 Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB Recruiting NCT02748356 Phase 2
20 Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB Recruiting NCT02748317 Phase 2
21 Efficacy of Acetaminophen in Posterior Fossa Surgery Recruiting NCT02532322 Phase 2
22 Post T-plant Infusion of Allogeneic Cytokine Induced Killer Cells as Consolidative Therapy in Myelodysplastic Syndromes/Myeloproliferative Disorders Active, not recruiting NCT01392989 Phase 2
23 Augmentation Cystoplasty Using an Autologous Neo-Bladder Terminated NCT00419120 Phase 2
24 Probiotics in Girls With Spina Bifida Withdrawn NCT00767988 Phase 2
25 Bacteriuria Eradication Through Probiotics Unknown status NCT00717600 Phase 1
26 Does Mid-Gestation Placental Function Assessment Reduce Psychological Distress in Women With High-Risk Pregnancies? Unknown status NCT00546026 Phase 1
27 Prevention of Neural Tube Defects by Inositol in Conjunction With Folic Acid (PONTI Study) Completed NCT00452829 Phase 1
28 Fetoscopic Meningomyelocele Repair Study Recruiting NCT02230072 Phase 1
29 The Impact of Community-based Wellness Programs on The Triple Aim Recruiting NCT02938130 Phase 1
30 Genetics of Neural Tube Defects Unknown status NCT01253746
31 Study of Genetic Risk Factors for Spina Bifida and Anencephaly Unknown status NCT00031122
32 Assessment of Functional Independence and Quality of Life in Adolescents With Spina Bifid Unknown status NCT00966927
33 Effect of Psycho-education on Gestational Weight Gain and Anxiety/Depression in Obese Pregnant Women Unknown status NCT01329835
34 Parental One-carbon Folate and Choline Nutrition Modulates Risk of Off-spring Cancer Development: Human Cohort Study Unknown status NCT02266641
35 Chiari Study Looking at Use of Duragen Versus Duraguard Unknown status NCT00565435
36 Reciprocating Gait Orthoses for Paraplegia Patients Unknown status NCT02227407
37 Comparing Urinary Tract Infections in Children With Spina Bifida Using Two Types of Catheters for Catheterization Completed NCT01263392
38 Outcome of Fetal Spina Bifida Completed NCT01100697
39 Cognitive Rehabilitation in Patients With Spina Bifida Completed NCT01302314
40 Management of Myelomeningocele Study (MOMS) Completed NCT00060606
41 Influence of "Espresso" on Adsorption of Myo-inositol Completed NCT01244399
42 Metformin in Children With Motor Deficit Completed NCT00720161
43 Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population Completed NCT00341068
44 3D-printed Module-assisted Minimally Invasive Lumbar Pedicle Screw Placement Completed NCT02970578
45 Efficacy of Weekly Versus Daily Folic Acid Supplementation Completed NCT00394862
46 Dosage Effects of Folic Acid on Blood Folates of Honduran Women Completed NCT00207532
47 Blood Folate and Homocysteine Levels Following Administration of Folic Acid According to Different Daily Dosing Schedules:a Simulation of Food Fortification Completed NCT00207558
48 Folate Metabolism in Normal Weight and Obese Women of Child-bearing Age Completed NCT01743196
49 Prevention of Post Operative Bone Loss in Children Completed NCT00655681
50 Prevention of Urinary Tract Infection (UTI) in Persons With Spinal Cord Injury (SCI) Completed NCT00309114

Search NIH Clinical Center for Tethered Spinal Cord Syndrome

Cochrane evidence based reviews: spinal dysraphism

Genetic Tests for Tethered Spinal Cord Syndrome

Genetic tests related to Tethered Spinal Cord Syndrome:

id Genetic test Affiliating Genes
1 Spinal Dysraphism 29

Anatomical Context for Tethered Spinal Cord Syndrome

MalaCards organs/tissues related to Tethered Spinal Cord Syndrome:

Spinal Cord

Publications for Tethered Spinal Cord Syndrome

Articles related to Tethered Spinal Cord Syndrome:

(show all 24)
id Title Authors Year
Association between chromosomal aberration of COX8C and tethered spinal cord syndrome: array-based comparative genomic hybridization analysis. ( 27651783 )
Adult intradural lipoma with tethered spinal cord syndrome. ( 25073248 )
Tethered spinal cord syndrome detected during ultrasound for caudal block in a child with single urological anomaly. ( 23814660 )
MRI findings, surgical treatment and follow-up of a myelomeningocele with tethered spinal cord syndrome in a cat. ( 21439878 )
Electrophysiologically guided untethering of secondary tethered spinal cord syndrome. ( 20594001 )
Tethered spinal cord syndrome with symptomatic onset in adulthood. ( 19951591 )
Intermittent back and leg pain with numbness. Tethered spinal cord syndrome. ( 18841738 )
Tethered spinal cord syndrome--the importance of time for outcomes. ( 17638158 )
Tethered spinal cord syndrome. ( 17615225 )
Congenital tethered spinal cord syndrome in adults. ( 16749759 )
Surgical treatment of tethered spinal cord syndrome in a dog with myelomeningocele. ( 11442238 )
Successful pregnancies in a case of retrograde ejaculation associated with tethered spinal cord syndrome. ( 10955250 )
Unilateral hyperhidrosis, callosities, and nail dystrophy in a boy with tethered spinal cord syndrome. ( 9875980 )
Congenital tethered spinal cord syndrome in adults. ( 9609288 )
Urodynamic findings in the tethered spinal cord syndrome: does surgical release improve bladder function? ( 8996368 )
Intraoperative monitoring for tethered spinal cord syndrome. ( 1750002 )
Pre- and postoperative urodynamic findings in children with tethered spinal cord syndrome. ( 2022217 )
The tethered spinal cord syndrome: a correlation of radiological features and peroperative findings in 30 patients. ( 2717007 )
MR imaging in the tethered spinal cord syndrome. ( 2784267 )
Evaluation of children and young adults with tethered spinal cord syndrome. Utility of spinal and scalp recorded somatosensory evoked potentials. ( 3738717 )
Urinary tract dysfunctions in tethered spinal cord syndrome: improvement after surgical untethering. ( 3889376 )
Adult onset of tethered spinal cord syndrome due to fibrous diastematomyelia: case report. ( 3889701 )
The tethered spinal cord syndrome. ( 6395542 )
Neurogenic bladder and the tethered spinal cord syndrome. ( 458974 )

Variations for Tethered Spinal Cord Syndrome

Expression for Tethered Spinal Cord Syndrome

Search GEO for disease gene expression data for Tethered Spinal Cord Syndrome.

Pathways for Tethered Spinal Cord Syndrome

GO Terms for Tethered Spinal Cord Syndrome

Biological processes related to Tethered Spinal Cord Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 anatomical structure morphogenesis GO:0009653 8.62 HOXA1 MNX1

Molecular functions related to Tethered Spinal Cord Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 8.8 HOXA1 MNX1 NKX2-8

Sources for Tethered Spinal Cord Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
65 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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