MCID: TTH004
MIFTS: 30

Tethered Spinal Cord Syndrome malady

Neuronal category

Summaries for Tethered Spinal Cord Syndrome

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Tethered spinal cord syndrome is a neurological disorder caused by tissue attachments that limit the movement of the spinal cord within the spinal column.

MalaCards: Tethered Spinal Cord Syndrome, also known as spinal dysraphism, is related to adult syndrome and n syndrome. An important gene associated with Tethered Spinal Cord Syndrome is HOXA1 (homeobox A1). Affiliated tissues include spinal cord, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Wikipedia:64 Tethered spinal cord syndrome (TCS) or occult spinal dysraphism sequence refers to a group of... more...

Aliases & Classifications for Tethered Spinal Cord Syndrome

Sources:
8Disease Ontology, 44NINDS, 10DISEASES, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

tethered spinal cord syndrome 8 44 10
spinal dysraphism 8


External Ids:

Disease Ontology8 DOID:1089
ICD9CM27 741
MeSH35 D016135

Related Diseases for Tethered Spinal Cord Syndrome

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tethered Spinal Cord Syndrome:



Diseases related to tethered spinal cord syndrome

Clinical Features for Tethered Spinal Cord Syndrome

Drugs & Therapeutics for Tethered Spinal Cord Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Tethered Spinal Cord Syndrome

Genetic Tests for Tethered Spinal Cord Syndrome

Anatomical Context for Tethered Spinal Cord Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Tethered Spinal Cord Syndrome:

33
Spinal cord

Animal Models for Tethered Spinal Cord Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Tethered Spinal Cord Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.9CYS1, GDF6, HOXA1
2MP:00053828.8LMNB1, HOXA1, GDF6, CASK
3MP:00036318.2LMNB1, HOXA1, GDF6, CYS1, CASK

Publications for Tethered Spinal Cord Syndrome

Sources:
51PubMed
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Articles related to Tethered Spinal Cord Syndrome:

(show all 29)
idTitleAuthorsYear
1
Tethered spinal cord syndrome detected during ultrasound for caudal block in a child with single urological anomaly. (23814660)
2013
2
A case of Proteus syndrome with severe spinal canal stenosis, scoliosis, and thoracic deformity associated with tethered cord. (22223075)
2012
3
MRI findings, surgical treatment and follow-up of a myelomeningocele with tethered spinal cord syndrome in a cat. (21439878)
2011
4
Electrophysiologically guided untethering of secondary tethered spinal cord syndrome. (20594001)
2010
5
Tethered spinal cord syndrome with symptomatic onset in adulthood. (19951591)
2009
6
Intermittent back and leg pain with numbness. Tethered spinal cord syndrome. (18841738)
2008
7
Tethered spinal cord syndrome--the importance of time for outcomes. (17638158)
2007
8
Tethered spinal cord syndrome. (17615225)
2007
9
Rubinstein-Taybi syndrome in children with tethered spinal cord. (17328274)
2006
10
Prevalence of primary tethered cord syndrome associated with occult spinal dysraphism in primary school children in Turkey. (16357495)
2006
11
Midline defects in FG syndrome: does tethered spinal cord contribute to the phenotype? (15812461)
2005
12
Surgical treatment of tethered spinal cord syndrome in a dog with myelomeningocele. (11442238)
2001
13
Tethered cord syndrome and occult spinal dysraphism. (16749753)
2001
14
Congenital tethered spinal cord syndrome in adults. (16749759)
2001
15
Successful pregnancies in a case of retrograde ejaculation associated with tethered spinal cord syndrome. (10955250)
2000
16
Radiologic and histopathologic findings in a rare case of complex occult spinal dysraphism with association of a lumbar fibrolipoma, neurenteric cyst and tethered cord syndrome. (9569336)
1998
17
Unilateral hyperhidrosis, callosities, and nail dystrophy in a boy with tethered spinal cord syndrome. (9875980)
1998
18
Tethered cord syndrome in occult spinal dysraphism: timing and outcome of surgical release. (9633724)
1998
19
Congenital tethered spinal cord syndrome in adults. (9609288)
1998
20
Urodynamic findings in the tethered spinal cord syndrome: does surgical release improve bladder function? (8996368)
1997
21
Intraoperative monitoring for tethered spinal cord syndrome. (1750002)
1991
22
Pre- and postoperative urodynamic findings in children with tethered spinal cord syndrome. (2022217)
1991
23
The tethered spinal cord syndrome: a correlation of radiological features and peroperative findings in 30 patients. (2717007)
1989
24
MR imaging in the tethered spinal cord syndrome. (2784267)
1989
25
Evaluation of children and young adults with tethered spinal cord syndrome. Utility of spinal and scalp recorded somatosensory evoked potentials. (3738717)
1986
26
Adult onset of tethered spinal cord syndrome due to fibrous diastematomyelia: case report. (3889701)
1985
27
Urinary tract dysfunctions in tethered spinal cord syndrome: improvement after surgical untethering. (3889376)
1985
28
The tethered spinal cord syndrome. (6395542)
1984
29
Neurogenic bladder and the tethered spinal cord syndrome. (458974)
1979

Genetic Variations for Tethered Spinal Cord Syndrome

Expression for genes affiliated with Tethered Spinal Cord Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tethered Spinal Cord Syndrome

Search GEO for disease gene expression data for Tethered Spinal Cord Syndrome.

Pathways for genes affiliated with Tethered Spinal Cord Syndrome

Compounds for genes affiliated with Tethered Spinal Cord Syndrome

GO Terms for genes affiliated with Tethered Spinal Cord Syndrome

Sources:
16Gene Ontology
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Cellular components related to Tethered Spinal Cord Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cilium membraneGO:0601709.3CYS1, CASK

Biological processes related to Tethered Spinal Cord Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inner ear developmentGO:0488399.5HOXA1, CYS1

Products for genes affiliated with Tethered Spinal Cord Syndrome

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Sources for Tethered Spinal Cord Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet