MCID: TTH004
MIFTS: 30

Tethered Spinal Cord Syndrome malady

Neuronal diseases category

Summaries for Tethered Spinal Cord Syndrome

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Tethered spinal cord syndrome is a neurological disorder caused by tissue attachments that limit the movement of the spinal cord within the spinal column.

MalaCards: Tethered Spinal Cord Syndrome, also known as spinal dysraphism, is related to adult syndrome and occult spinal dysraphism. An important gene associated with Tethered Spinal Cord Syndrome is HOXA1 (homeobox A1). Affiliated tissues include spinal cord, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Wikipedia:63 Tethered spinal cord syndrome (TCS) or occult spinal dysraphism sequence refers to a group of... more...

Aliases & Classifications for Tethered Spinal Cord Syndrome

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8Disease Ontology, 43NINDS, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

tethered spinal cord syndrome 8 43 10
spinal dysraphism 8


External Ids:

Disease Ontology8 DOID:1089
ICD9CM27 741
MeSH34 D016135

Related Diseases for Tethered Spinal Cord Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tethered Spinal Cord Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 29)
idRelated DiseaseScoreTop Affiliating Genes
1adult syndrome10.6
2occult spinal dysraphism10.4
3spina bifida10.4
4neurogenic bladder10.3
5image syndrome10.3
6primary tethered chord syndrome10.3
7situs inversus10.2
8imperforate anus10.2
9cervicitis10.2
10hypertrichosis10.2
11lipoma10.2
12meningitis10.2
13neurogenic arthropathy10.1
14lumbosacral lipoma10.1
15achondroplasia10.1
16spinal cord intramedullary teratoma10.1
17melas syndrome10.1
18myxopapillary ependymoma10.1
19cleft lip10.1
20cleft palate10.1
21spinal cord lipoma10.1
22adult teratoma10.1
23arthropathy10.1
24capillary hemangioma10.1
25hemangioma10.1
26mature teratoma10.1
27dwarfism10.1
28mitochondrial disorders10.1
29exstrophy-epispadias complex10.1

Graphical network of the top 20 diseases related to Tethered Spinal Cord Syndrome:



Diseases related to tethered spinal cord syndrome

Clinical Features for Tethered Spinal Cord Syndrome

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Drugs & Therapeutics for Tethered Spinal Cord Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Tethered Spinal Cord Syndrome

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Anatomical Context for Tethered Spinal Cord Syndrome

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32MalaCards
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MalaCards organs/tissues related to Tethered Spinal Cord Syndrome:

32
Spinal cord

Animal Models for Tethered Spinal Cord Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tethered Spinal Cord Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.9GDF6, HOXA1, CYS1
2MP:00053828.8LMNB1, HOXA1, GDF6, CASK
3MP:00036318.2CYS1, CASK, HOXA1, LMNB1, GDF6

Publications for Tethered Spinal Cord Syndrome

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50PubMed
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Articles related to Tethered Spinal Cord Syndrome:

(show all 31)
idTitleAuthorsYear
1
Tethered spinal cord syndrome detected during ultrasound for caudal block in a child with single urological anomaly. (23814660)
2013
2
A case of Proteus syndrome with severe spinal canal stenosis, scoliosis, and thoracic deformity associated with tethered cord. (22223075)
2012
3
Amniotic band syndrome with tethering of the spinal cord: a case-based update. (21080173)
2011
4
MRI findings, surgical treatment and follow-up of a myelomeningocele with tethered spinal cord syndrome in a cat. (21439878)
2011
5
Electrophysiologically guided untethering of secondary tethered spinal cord syndrome. (20594001)
2010
6
Tethered spinal cord syndrome with symptomatic onset in adulthood. (19951591)
2009
7
Intermittent back and leg pain with numbness. Tethered spinal cord syndrome. (18841738)
2008
8
Tethered spinal cord syndrome--the importance of time for outcomes. (17638158)
2007
9
Tethered spinal cord syndrome. (17615225)
2007
10
Rubinstein-Taybi syndrome in children with tethered spinal cord. (17328274)
2006
11
Prevalence of primary tethered cord syndrome associated with occult spinal dysraphism in primary school children in Turkey. (16357495)
2006
12
Midline defects in FG syndrome: does tethered spinal cord contribute to the phenotype? (15812461)
2005
13
Surgical treatment of tethered spinal cord syndrome in a dog with myelomeningocele. (11442238)
2001
14
Tethered cord syndrome and occult spinal dysraphism. (16749753)
2001
15
Congenital tethered spinal cord syndrome in adults. (16749759)
2001
16
Successful pregnancies in a case of retrograde ejaculation associated with tethered spinal cord syndrome. (10955250)
2000
17
Spinal cord tethering associated with amniotic band syndrome. (10705926)
1999
18
Radiologic and histopathologic findings in a rare case of complex occult spinal dysraphism with association of a lumbar fibrolipoma, neurenteric cyst and tethered cord syndrome. (9569336)
1998
19
Unilateral hyperhidrosis, callosities, and nail dystrophy in a boy with tethered spinal cord syndrome. (9875980)
1998
20
Tethered cord syndrome in occult spinal dysraphism: timing and outcome of surgical release. (9633724)
1998
21
Congenital tethered spinal cord syndrome in adults. (9609288)
1998
22
Urodynamic findings in the tethered spinal cord syndrome: does surgical release improve bladder function? (8996368)
1997
23
Intraoperative monitoring for tethered spinal cord syndrome. (1750002)
1991
24
Pre- and postoperative urodynamic findings in children with tethered spinal cord syndrome. (2022217)
1991
25
The tethered spinal cord syndrome: a correlation of radiological features and peroperative findings in 30 patients. (2717007)
1989
26
MR imaging in the tethered spinal cord syndrome. (2784267)
1989
27
Evaluation of children and young adults with tethered spinal cord syndrome. Utility of spinal and scalp recorded somatosensory evoked potentials. (3738717)
1986
28
Adult onset of tethered spinal cord syndrome due to fibrous diastematomyelia: case report. (3889701)
1985
29
Urinary tract dysfunctions in tethered spinal cord syndrome: improvement after surgical untethering. (3889376)
1985
30
The tethered spinal cord syndrome. (6395542)
1984
31
Neurogenic bladder and the tethered spinal cord syndrome. (458974)
1979

Genetic Variations for Tethered Spinal Cord Syndrome

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Expression for genes affiliated with Tethered Spinal Cord Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tethered Spinal Cord Syndrome

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Pathways for genes affiliated with Tethered Spinal Cord Syndrome

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Compounds for genes affiliated with Tethered Spinal Cord Syndrome

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GO Terms for genes affiliated with Tethered Spinal Cord Syndrome

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16Gene Ontology
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Cellular components related to Tethered Spinal Cord Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cilium membraneGO:0601709.3CYS1, CASK

Biological processes related to Tethered Spinal Cord Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inner ear developmentGO:0488399.5HOXA1, CYS1

Products for genes affiliated with Tethered Spinal Cord Syndrome

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Sources for Tethered Spinal Cord Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet