Tetralogy of Fallot malady

NIH Rare Diseases: Tetralogy of Fallot is a complex congenital heart defect characterized by a large ventricular septal defect (hole between the right and left ventricles), pulmonary stenosis (narrowing of the valve and artery that connect the heart with the lungs), an overriding aorta (the aorta - the artery that carries oxygen-rich blood to the body - is shifted over the right ventricle and ventricular septal defect, instead of coming out only from the left ventricle), and right ventricular hypertrophy (the muscle of the right ventricle is thicker than usual). Tetralogy of Fallot causes low oxygen levels in the blood, which can lead to cyanosis (a bluish-purple color to the skin). The cause of this condition is unknown. Treatment involves surgery to repair the heart defects. Sometimes more than one surgery is needed. ³⁰

MalaCards: Tetralogy of Fallot, also known as atresia, dextraposition of aorta, and hypertrophy of right ventricle, is related to atrial heart septal defect and ventricular septal defect. An important gene associated with Tetralogy of Fallot is DGCR (DiGeorge syndrome chromosome region), and among its related pathways are HOP Signaling and Cardiomyocyte Differentiation through BMP Receptors. The compounds ascorbic acid and apocynin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and lung, and related mouse phenotypes are taste/olfaction and hematopoietic system.

Wikipedia: Tetralogy of Fallot (TOF) is a congenital heart defect which is classically understood to involve four...⁴⁴ more...

OMIM: 187500

Aliases & Descriptions:

tetralogy of fallot 6 7 30 8 33 atresia, dextraposition of aorta, and hypertrophy of right ventricle 6 ventricular septal defect with pulmonary stenosis 6 tetralogy of fallot, unspecified (disorder) 6 tetralogy of fallot nos (disorder) 6

tetralogy of fallot, unspecified 6 tetralogy of fallot (disorder) 6 heart septal defects 43 fallot tetralogy 30 tof 30

Diseases related to tetralogy of fallot by text searches and GeneDecks gene sharing:

(show top 50)    (show all 429)

id	Related Disease	Score	Top Affiliating Genes
1	atrial heart septal defect	33.7	NPPB, NKX2-5, GATA4
2	ventricular septal defect	32.3	JAG1, NPPB, NKX2-5, GATA4
3	mckusick-kaufman syndrome	31.6	BBS1, BBS2, BBS4, BBS7, JAG1, MKKS
4	polydactyly	31.4	BBS1, BBS2, BBS4, BBS7, MKKS
5	patent foramen ovale	30.5	F5, NKX2-5
6	congenital heart defect	30.3	S100A1, MMP3, GJA1, NPPA, NPPB, NKX2-5
7	atrioventricular septal defect	30.0	ZNF74, CLTCL1, GJA1, TBX1, EDN1, ACP6
8	conotruncal anomaly face syndrome	28.5	UFD1L, TBX1, DGCR
9	velocardiofacial syndrome	28.0	ZNF74, CLTCL1, UFD1L, TBX1, HIRA, DGCR
10	digeorge syndrome	27.3	ZNF74, CLTCL1, UFD1L, MTHFR, TBX1, HIRA
11	cerebral infarction	25.8	MTHFR, MMP3, MMP9, IL6, APOE, ENO2
12	polyneuropathy	25.2	MMP9, IL6, APOE, CAT, DBH, SOD1
13	silicosis	24.8	IL6, IL8, CAT, SOD1
14	blindness	23.9	REN, MTHFR, MMP9, IL6, IL8, APOE
15	fibrosis	23.0	REN, BBS1, BBS7, MTHFR, S100A1, MMP3
16	purpura	23.0	MTHFR, JAG1, MMP9, IL6, IL8, F5
17	nasopharyngitis	22.7	MTHFR, MMP3, MMP9, IL6, IL8, ENO2
18	amyotrophic lateral sclerosis	22.6	MTHFR, MMP3, MMP9, FEZF2, IL8, APOE
19	hypoxia	22.5	REN, CITED2, MMP3, MMP9, IL6, IL8
20	ovarian carcinoma	22.3	MTHFR, S100A1, MMP9, IL6, IL8, ENO2
21	osteosarcoma	22.2	MTHFR, S100A1, MMP9, IL6, IL8, FBN1
22	lateral sclerosis	22.2	MTHFR, MMP3, MMP9, FEZF2, IL8, APOE
23	cystic fibrosis	21.8	REN, MMP9, IL6, IL8, F5, CAT
24	breast cancer	21.6	CITED2, BBS4, MTHFR, S100A1, JAG1, MMP3
25	pancreatic cancer	21.3	REN, MTHFR, MMP9, IL6, IL8, ENO2
26	cerebritis	21.3	REN, BBS2, BBS4, MTHFR, JAG1, MMP3
27	alzheimer's disease	19.8	REN, MTHFR, JAG1, MMP3, MMP9, IL6
28	arthritis	19.7	MTHFR, S100A1, JAG1, MMP3, MMP9, MKKS
29	carcinoma	19.6	REN, ZFPM2, MTHFR, S100A1, JAG1, MMP3
30	gastric cancer	19.4	CITED2, UFD1L, MTHFR, S100A1, JAG1, MMP3
31	cholesterol	19.3	REN, UFD1L, MTHFR, MMP3, MMP9, IL6
32	hepatitis	18.8	REN, MTHFR, S100A1, JAG1, MMP3, MMP9
33	pancreatitis	18.2	REN, MTHFR, S100A1, MMP3, MMP9, IL6
34	conotruncal heart malformations	13.9	CFC1, TBX1, GDF1
35	faces syndrome	13.8	UFD1L, TBX1, DGCR
36	congenital heart block	13.8	NPPB, NKX2-5, GATA4
37	ebstein anomaly	13.7	TBX1, NPPB, NKX2-5, GATA4
38	meckel syndrome	13.7	BBS1, BBS2, BBS4, BBS7, MKKS
39	pulmonary valve stenosis	13.6	CLTCL1, JAG1, HIRA
40	pigmentary retinopathy	13.6	BBS1, BBS2, BBS4, BBS7, MKKS
41	hypoplastic left heart syndrome	13.6	GJA1, SMYD1, NKX2-5
42	bardet-biedl syndrome	13.6	BBS1, BBS2, BBS4, BBS7, MKKS
43	double outlet right ventricle	13.6	VANGL2, ZFPM2, CFC1, TBX1, NKX2-5, GATA4
44	mitral valve insufficiency	13.5	FBN1, NPPA, NPPB
45	retinal disease	13.5	BBS1, BBS2, BBS4, BBS7, MKKS
46	cerebral arteriosclerosis	13.4	CALCA, EDN1
47	postural hypotension	13.4	REN, DBH, NPPA
48	carcinoid tumor of lung	13.4	ENO2, CALCA, NPY
49	renal hypertension	13.3	REN, EDN1, DBH
50	postural orthostatic tachycardia syndrome	13.3	REN, NDUFS4, DBH

Clinical features from OMIM: 187500

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to tetralogy of fallot:

²²

MGI Mouse Phenotypes related to tetralogy of fallot:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	9.9	ENO2, MKKS, BBS4, BBS2, BBS1
2	hematopoietic system phenotype	MP:0005397	9.6	GDF1, GATA4, NKX2-5, TOP3B, TBX1, GJA1
3	endocrine/exocrine gland phenotype	MP:0005379	9.6	GDF1, DBH, TOP3B, TBX1, GJA1, BBS4
4	renal/urinary system phenotype	MP:0005367	9.2	FBN1, APOE, TOP3B, NPPA, GDF1, JAG1
5	embryogenesis phenotype	MP:0005380	9.0	HIRA, TFAP2C, NKX2-5, HAND1, GATA6, GATA4
6	integument phenotype	MP:0010771	8.9	NDUFS4, TOP3B, DBH, NKX2-5, GATA4, TBX1
7	no phenotypic analysis	MP:0003012	8.8	GATA4, NKX2-5, HIRA, TBX1, GJA1, FBN1
8	craniofacial phenotype	MP:0005382	8.6	TBX1, EDN1, HEY2, HIRA, NKX2-5, HAND1
9	hearing/vestibular/ear phenotype	MP:0005377	8.4	TBX1, CYBA, NTRK3, EDN1, SOD1, GJA1
10	liver/biliary system phenotype	MP:0005370	8.3	GDF1, GATA4, GATA6, SOD1, HEY2, IL6
11	limbs/digits/tail phenotype	MP:0005371	8.3	FBN1, APOE, GJA1, TBX1, HAND1, MKKS
12	normal phenotype	MP:0002873	8.2	PKIA, NDUFS4, TFAP2C, NPY, NKX2-5, HAND1
13	respiratory system phenotype	MP:0005388	8.0	GDF1, BBS4, BBS1, CITED2, ZFPM2, VANGL2
14	skeleton phenotype	MP:0005390	7.7	GDF1, NDUFS4, TBX1, GJA1, CALCA, IL6
15	digestive/alimentary phenotype	MP:0005381	7.7	APOE, TBX1, EDN1, TOP3B, NPY, GATA4
16	reproductive system phenotype	MP:0005389	7.4	FBN1, GJA1, TOP3B, ADIPOQ, GATA4, IL6
17	nervous system phenotype	MP:0003631	6.9	GDF1, FEZF2, MKKS, MTHFR, BBS7, BBS4
18	vision/eye phenotype	MP:0005391	6.7	IL6, APOE, GJA1, NTRK3, NDUFS4, DBH
19	behavior/neurological phenotype	MP:0005386	6.1	F5, CALCA, GJA1, TBX1, CYBA, NTRK3
20	cellular phenotype	MP:0005384	5.6	SMYD1, NDUFS4, TOP3B, SOD1, NKX2-5, ADIPOQ
21	immune system phenotype	MP:0005387	5.6	GJA1, TBX1, CYBA, NDUFS4, TOP3B, SOD1
22	muscle phenotype	MP:0005369	5.5	SMYD1, TBX1, GJA1, APOE, FBN1, IL6
23	growth/size phenotype	MP:0005378	5.4	HIRA, HEY2, NDUFS4, SMYD1, NTRK3, TFAP2C
24	mortality/aging	MP:0010768	4.9	HEY2, EDN1, SMYD1, NTRK3, TBX1, GJA1
25	cardiovascular system phenotype	MP:0005385	3.8	GDF1, GATA4, GATA6, HAND1, ADIPOQ, NKX2-5
26	homeostasis/metabolism phenotype	MP:0005376	3.4	HIRA, HEY2, EDN1, NDUFS4, TBX1, GJA1

Articles related to tetralogy of fallot:

(show all 43)

id	Title	Authors	Year	Affiliating Genes
1	Investigation of somatic NKX2-5, GATA4 and HAND1 muta tions in patients with tetralogy of Fallot. (21519287)	Wang J.... Fu Q.	2011	GATA4, HAND1, NKX2-5
2	Somatic mutations in NKX2a895, GATA4, and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart. (22043484)	Esposito G.... Winlaw D.S.	2011	GATA4, HAND1, NKX2-5
3	Systematic survey of variants in TBX1 in non-syndromi c tetralogy of Fallot identifies a novel 57 base pair deletion that reduces tra nscriptional activity but finds no evidence for association with common variant s. (20937753)	Griffin H.R.... Goodship J.A.	2010	TBX1
4	Modulating effects of matrix metalloproteinase-3 and -9 polymorphisms on aortic stiffness and aortic root dilation in patients after tetralogy of Fallot repair. (20541269)	Cheung Y.F.... Wong S.J.	2010	MMP3, MMP9
5	A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect. (20631719)	Lin X.... Chen Y.H.	2010	GATA6
6	Comprehensive genotype-phenotype analysis in 230 pati ents with tetralogy of Fallot. (19948535)	Rauch R.... Rauch A.	2010	JAG1, TBX1, NKX2-5
7	Diffuse cerebral infarct associated with factor V Lei den and prothrombin 20210A mutations in a patient with tetralogy of Fallot. (18550588)	Sipahi T.... Akar N.	2009	F5
8	The tetralogy of Fallot-associated G274D mutation imp airs folding of the second epidermal growth factor repeat in Jagged-1. (19780835)	Guarnaccia C.... Pongor S.	2009	JAG1
9	Assessment of biventricular functional reserve and NT -proBNP levels in patients with RV volume overload after repair of tetralogy of Fallot at young age. (18495276)	van den Berg J.... Helbing W.A.	2009	NPPB
10	Tetralogy of fallot as a model to study cardiac proge nitor cell migration and differentiation during heart development. (19818949)	Di Felice V.... Zummo G.	2009	NKX2-5
11	Genetic screening of the canine zinc finger protein m ultitype 2 (cZFPM2) gene in dogs with tetralogy of Fallot (TOF). (19630881)	Lee J.S.... Hyun C.	2009	ZFPM2
12	The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot. (19894660)	Marinho C.... Bicho M.	2009	MTHFR
13	Effect of captopril on pulmonary artery pressure foll owing corrective surgery for tetralogy of fallot. (19740297)	Ma Z.S.... Wang L.X.	2009	EDN1
14	Decreased expression of neurotrophic tyrosine receptor kinase 3 is associated with the outflow tract defect of human tetralogy of Fallot. (19187638)	Kong B.... LA1 X.D.	2009	NTRK3
15	Role of fibrillin-1 genetic mutations and polymorphism in aortic dilatation in patients undergoing intracardiac repair of tetralogy of Fallot. (18805282)	Chowdhury U.K.... Subramaniam G.K.	2008	FBN1
16	Genetic factors are important determinants of neurodevelopmental outcome after repair of tetralogy of Fallot. (18179924)	Zeltser I.... Gaynor J.W.	2008	APOE
17	Evaluation of right ventricular functions and B-type natriuretic peptide levels by cardiopulmonary exercise test in patients with pulmonary regurgitation after repair of tetralogy of Fallot. (18928486)	Cetin I.... AA9lamaci S.	2008	NPPB
18	Amino-terminal fragment of pro-brain natriuretic hormone identifies functional impairment and right ventricular overload in operated tetralogy of Fallot patients. (17607499)	Festa P.... Passino C.	2007	NPPB
19	Mutation analysis of the Vangl2 coding region revealed no common cause for Tetralogy of Fallot. (18034999)	Erdal E.... Acikel U.	2007	VANGL2
20	Metabolic derangements in an adult patient with tetralogy of Fallot: possible role of chronic systemic hypoxia. (18030188)	Harada E.... Masuzaki H.	2007	ADIPOQ
21	Polymorphism C242T of the gene of the p22phox subunit for nicotinamide adenine dinucleotide phosphate oxidase, and erythrocytic antioxidant enzymes, in patients with tetralogy of Fallot. (17445342)	Guerra A.... Bicho M.	2007	CYBA
22	Plasma brain natriuretic peptide levels, right ventricular volume overload and exercise capacity in adolescents after surgical repair of tetralogy of Fallot. (17182138)	Cheung E.W.... Cheung Y.F.	2007	NPPB
23	A prospective, randomized, double-blind, placebo controlled trial of beta-blockade in patients who have undergone surgical correction of tetralogy of Fallot. (17572925)	Norozi K.... Buchhorn R.	2007	NPPB, NPPA
24	N-terminal pro-brain natriuretic peptide as a marker in follow-up patients with tetralogy of Fallot after total correction. (17607502)	Khositseth A.... Attanawanich S.	2007	NPPB
25	Effects of volume and/or pressure overload secondary to congenital heart disease (tetralogy of fallot or pulmonary stenosis) on right ventricular function using cardiovascular magnetic resonance and B-type natriuretic peptide levels. (16563914)	Oosterhof T.... Mulder B.J.	2006	NPPB
26	A novel mutation in the GATA4 gene in patients with Tetralogy of Fallot. (16470721)	Nemer G.... Bitar F.	2006	GATA4
27	Ventricular fibrosis suggested by cardiovascular magnetic resonance in adults with repaired tetralogy of fallot and its relationship to adverse markers of clinical outcome. (16432072)	Babu-Narayan S.V.... Gatzoulis M.A.	2006	NPPB, NPPA
28	The expression of connexin 43 in children with Tetralogy of Fallot. (16010294)	Kol/cz J.... Malec E.	2005	GJA1
29	Plasma N-terminal pro-brain natriuretic peptide as a marker of right ventricular dysfunction in patients with tetralogy of Fallot after surgical repair. (16236924)	Norozi K.... Wessel A.	2005	REN, EDN1, NPPB
30	Usefulness of exercise-induced changes in plasma levels of brain natriuretic peptide in predicting right ventricular contractile reserve after repair of tetralogy of Fallot. (15904640)	Ishii H.... Takada G.	2005	NPPB
31	A female with complete lack of Mullerian fusion, postaxial polydactyly, and tetralogy of fallot: genetic heterogeneity of McKusick-Kaufman syndrome or a unique syndrome? (15266619)	Slavotinek A.M.... Stratton P.	2004	BBS4, BBS2, MKKS
32	Lung perfusion with protective solution relieves lung injury in corrections of Tetralogy of Fallot. (14992899)	Wei B.... Ruan Y.	2004	IL6, IL8
33	Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot. (14517948)	Pizzuti A.... Dallapiccola B.	2003	ZFPM2
34	Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice. (12372254)	Donovan J.... Utset M.F.	2002	JAG1, HEY2
35	Familial tetralogy of Fallot caused by mutation in the Jagged1 gene. (11152664)	Eldadah Z.A.... Dietz H.C.	2001	JAG1
36	NKX2.5 mutations in patients with tetralogy of fallot. (11714651)	Goldmuntz E.... Benson D.W.	2001	NKX2-5
37	Molecular characterization of tetralogy of fallot within Digeorge critical region of the chromosome 22. (11455393)	Lu J.H.... Lu J.K.	2001	UFD1L, HIRA
38	Absence of mutations in human ubiquitin fusion-degradation protein gene in tetralogy of Fallot. (11485030)	Chung M.Y.... Hwang B.	2001	UFD1L
39	Plasma concentrations of atrial and brain natriuretic peptides and cyclic guanosine monophosphate in response to dobutamine infusion in patients with surgically repaired tetralogy of fallot. (10441688)	Hayabuchi Y.... Kuroda Y.	1999	NPPB, NPPA
40	Expression of proto-oncogenes, genes for muscle specific isoforms and heat shock protein (HSP) -70 gene in hypertrophied cardiac muscles from patients with atrial septal defect or tetralogy of Fallot. (7833841)	Jegadeesh Babu G.... Rajamanickam C.	1994	HSPA14
41	Mitochondrial respiratory chain enzyme activities in tetralogy of Fallot. (8086770)	Maurer I.... Zierz S.	1994	NDUFS4
42	Effect of oxygen tension and cardiovascular operations on the myocardial antioxidant enzyme activities in patients with tetralogy of Fallot and aorta-coronary bypass. (1614202)	Teoh K.H.... Williams W.G.	1992	SOD1, CAT
43	Determination of infundibular innervation and amine receptor content in cyanotic and acyanotic myocardium: relation to clinical events in tetralogy of Fallot. (1652127)	McGrath L.B.... Levett J.M.	1991	ENO2, DBH, CALCA

Genes related to tetralogy of fallot according to GeneCards:

(show top 50)    (show all 62)

id	Symbol	Description	Score	GeneCards Section Context
1	DGCR	DiGeorge syndrome chromosome region	11.1	Summaries
2	NKX2-5	NK2 homeobox 5	11.1	Publications, Summaries
3	CFC1	cripto, FRL-1, cryptic family 1	11.0
4	GDF1	growth differentiation factor 1	11.0
5	HAND1	heart and neural crest derivatives expressed 1	11.0	Publications
6	SLN	sarcolipin	11.0
7	FEZF2	FEZ family zinc finger 2	11.0
8	FTSJ2	FtsJ RNA methyltransferase homolog 2 (E. coli)	11.0
9	VANGL2	vang-like 2 (van gogh, Drosophila)	11.0	Publications
10	GATA6	GATA binding protein 6	11.0	Publications
11	TBX1	T-box 1	11.0	Publications
12	UFD1L	ubiquitin fusion degradation 1 like (yeast)	11.0	Publications
13	JAG1	jagged 1	11.0	Publications
14	BBS1	Bardet-Biedl syndrome 1	11.0	Publications
15	BBS7	Bardet-Biedl syndrome 7	11.0	Publications
16	BBS2	Bardet-Biedl syndrome 2	11.0	Publications
17	ZNF74	zinc finger protein 74	11.0
18	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	11.0
19	TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	11.0
20	ALDH3B2	aldehyde dehydrogenase 3 family, member B2	11.0
21	TOP3B	topoisomerase (DNA) III beta	11.0
22	ACP6	acid phosphatase 6, lysophosphatidic	11.0
23	HSPA14	heat shock 70kDa protein 14	11.0	Publications
24	BBS4	Bardet-Biedl syndrome 4	11.0	Publications
25	IPPK	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	11.0	Disorders
26	GATA4	GATA binding protein 4	11.0	Publications
27	SMYD1	SET and MYND domain containing 1	11.0	Disorders
28	MKKS	McKusick-Kaufman syndrome	11.0	Publications
29	NPPB	natriuretic peptide B	11.0	Publications
30	SNX8	sorting nexin 8	11.0
31	S100A1	S100 calcium binding protein A1	11.0	Publications
32	SAE1	SUMO1 activating enzyme subunit 1	11.0
33	PKIA	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	11.0
34	CYBA	cytochrome b-245, alpha polypeptide	11.0	Publications
35	CLTCL1	clathrin, heavy chain-like 1	11.0
36	HIRA	HIR histone cell cycle regulation defective homolog A (S. cerevisiae)	11.0	Publications
37	DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	11.0	Publications
38	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	11.0	Disorders
39	EIF3B	eukaryotic translation initiation factor 3, subunit B	11.0
40	MEGF9	multiple EGF-like-domains 9	11.0	Disorders
41	ZFPM2	zinc finger protein, multitype 2	11.0	Publications
42	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
43	NPPA	natriuretic peptide A	11.0	Publications
44	NPY	neuropeptide Y	11.0	Publications
45	NDUFS4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	11.0	Publications
46	FBN1	fibrillin 1	11.0	Publications
47	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
48	GJA1	gap junction protein, alpha 1, 43kDa	11.0	Publications
49	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
50	EDN1	endothelin 1	11.0	Publications

Pathways related to tetralogy of fallot according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	HOP Signaling36	10.1	NPPA, NKX2-5, GATA4
2	Cardiomyocyte Differentiation through BMP Receptors36	9.7	NPPA, NPPB, NKX2-5, GATA4

Compounds related to tetralogy of fallot according to GeneDecks:

(show top 50)    (show all 135)

id	Compound	Score	Top Affiliating Genes
1	ascorbic acid32 18	11.5	FBN1, DBH
2	apocynin32	10.1	CAT, NDUFS4, CYBA
3	vanillylmandelic acid32 18	11.1	ALDH3B2, ENO2, REN, DBH
4	urodilatin32	10.0	REN, NPPA, NPPB, EDN1
5	trandolapril32 9 9	12.0	REN, NPPA, NPPB, EDN1
6	enalaprilat32	9.9	NPPA, NPPB, REN, EDN1
7	phosphoramidon32 9 9	11.8	NPY, NPPA, NPPB, EDN1, CALCA
8	toki-shakuyaku-san32	9.8	EDN1, REN, NPPA
9	hanp32	9.7	REN, EDN1, NPPA, NPPB, ADIPOQ
10	lisinopril32 9 18 9	12.7	NPY, NPPB, REN, NPPA
11	fosinopril32 9 9	11.7	NPPB, NPPA, MMP9, REN
12	carvedilol32 34 9 9	12.6	EDN1, NPPA, REN, NDUFS4, GJA1, NPPB
13	enalapril32 9 9	11.6	EDN1, NPPA, NPPB, ADIPOQ, REN
14	n acetylcysteine32	9.6	MMP3, APOE, CYBA, MMP9
15	omapatrilat32	9.6	MMP9, EDN1, REN, NPPA
16	spec-t32	9.6	APOE, NPPA, ENO2, CALCA, NPPB
17	sodium nitroprusside32	9.4	NPPA, REN, CAT, NPY, NPPB, ADIPOQ
18	1,3-dimethyl-2-thiourea32	9.4	CAT, SOD1, EDN1
19	carbenoxolone32 9 9	11.3	EDN1, GJA1, IL6, REN
20	oxygen32 18	10.2	NDUFS4, GJA1, FBN1, MMP3, DBH, NPPA
21	epinephrine32 9 18 9	12.2	NPPA, NPY, NPPB, MMP9, F5, DBH
22	acth32	9.1	DBH, GJA1, NPY, IL6, REN
23	l-nmma32	9.1	CAT, NPPB, EDN1, SOD1, NPPA, MMP9
24	losartan32 34 9 9	12.0	NPPA, APOE, REN, NPPB, EDN1, ADIPOQ
25	glutamate32	9.0	MTHFR, MMP3, CALCA, MMP9, GJA1, NDUFS4
26	forskolin32 42 9 9	11.8	GATA4, CALCA, REN, MMP3, ENO2, NPPA
27	homocysteine32 18	9.8	APOE, F5, NPPB, ADIPOQ, FBN1, GJA1
28	s-nitroso-n-acetylpenicillamine32	8.8	IL8, CAT, GJA1, EDN1, NPPB, SOD1
29	nifedipine32 9 9	10.7	ADIPOQ, MMP9, GJA1, EDN1, NPPA, REN
30	dopamine32 9 18 9	11.7	NDUFS4, MTHFR, ADIPOQ, NPPA, DBH, REN
31	uric acid32 18	9.7	SOD1, CAT, ENO2, MTHFR, NPPB, F5
32	acetylcholine32 9 18 9	11.5	CALCA, S100A1, APOE, ADIPOQ, MMP3, NPY
33	prostacyclin32	8.4	APOE, REN, F5, EDN1, SOD1, NPPA
34	gabexate mesilate32	8.4	F5, IL6, IL8, MMP9
35	testosterone32 9 18 9	11.1	NPPB, CALCA, NTRK3, F5, MTHFR, MMP9
36	atorvastatin32 34 9 18 9	12.1	APOE, ADIPOQ, F5, NPPB, EDN1, IL6
37	creatinine32	8.0	NPY, NPPB, EDN1, F5, ENO2, MMP9
38	indomethacin32 9 9	9.5	SOD1, MMP3, NPY, EDN1, CALCA, CAT
39	8-isoprostane32	7.5	EDN1, NPPB, ADIPOQ, MMP9, IL6, IL8
40	norepinephrine32 9 18 9	10.4	CALCA, NPY, NPPB, ADIPOQ, NPPA, DBH
41	simvastatin32 34 42 9 18 9	12.4	APOE, IL6, MMP9, MMP3, ADIPOQ, F5
42	sb 20358032 42	8.3	CAT, MMP9, MMP3, IL6, GJA1, EDN1
43	cyclosporin a32 42	7.9	CALCA, MMP9, IL6, IL8, APOE, EDN1
44	pge232	6.9	MMP3, MMP9, IL6, CALCA, GJA1, EDN1
45	retinoic acid32 42 18	8.6	GATA6, ADIPOQ, NPY, TFAP2C, GJA1, F5
46	vegf32	6.3	EDN1, NTRK3, GJA1, NPPB, IL8, F5
47	lactate32	6.2	CAT, ADIPOQ, IL6, MMP3, MMP9, IL8
48	estrogen32	6.2	MTHFR, NPPA, S100A1, MMP3, MMP9, IL6
49	nitric oxide32 9 18 9	8.8	NPPB, NDUFS4, EDN1, DBH, SOD1, NPPA
50	alanine32	5.8	FBN1, MTHFR, NPY, SOD1, DBH, GJA1

Cellular components related to tetralogy of fallot according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	motile cilium	GO:031514	10.2	BBS2, BBS4, MKKS
2	BBSome	GO:034464	10.2	BBS7, BBS4, BBS2, BBS1
3	cilium membrane	GO:060170	9.9	BBS7, BBS4, BBS2, BBS1
4	extracellular space	GO:005615	5.6	REN, GDF1, ADIPOQ, NPY, NPPB, SOD1
5	extracellular region	GO:005576	5.2	EDN1, ACP6, DBH, SOD1, NPPA, NPPB

Biological processes related to tetralogy of fallot according to GeneDecks:

(show all 39)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cardioblast differentiation	GO:051891	10.6	NKX2-5, GATA6, GATA4
2	pigment granule aggregation in cell center	GO:051877	10.6	MKKS, BBS7, BBS4
3	negative regulation of appetite by leptin-mediated signaling pathway	GO:038108	10.6	MKKS, BBS4, BBS2
4	regulation of cilium beat frequency involved in ciliary motility	GO:060296	10.6	MKKS, BBS4, BBS2
5	nonmotile primary cilium assembly	GO:035058	10.5	MKKS, BBS4, BBS1, VANGL2
6	outflow tract septum morphogenesis	GO:003148	10.5	ZFPM2, TBX1, NKX2-5, GATA6
7	melanosome transport	GO:032402	10.5	BBS2, BBS4, BBS7, MKKS
8	determination of left/right symmetry	GO:007368	10.5	TBX1, MKKS, CFC1, BBS7, CITED2
9	photoreceptor cell maintenance	GO:045494	10.5	BBS1, BBS2, BBS4, MKKS
10	striatum development	GO:021756	10.5	MKKS, BBS4, BBS2
11	trophectodermal cell differentiation	GO:001829	10.4	HAND1, TFAP2C, CITED2
12	cilium morphogenesis	GO:060271	10.4	BBS2, BBS4, BBS7, MKKS
13	brain morphogenesis	GO:048854	10.4	MKKS, BBS4, BBS2
14	cerebral cortex development	GO:021987	10.3	NPY, TFAP2C, MKKS, BBS4, BBS2
15	fat cell differentiation	GO:045444	10.3	MKKS, BBS7, BBS4, BBS2
16	cardiac muscle cell differentiation	GO:055007	10.3	NKX2-5, GATA6, GATA4
17	pulmonary artery morphogenesis	GO:061156	10.2	HEY2, JAG1, CITED2
18	retina homeostasis	GO:001895	10.2	SOD1, BBS4, BBS1
19	male gonad development	GO:008584	10.2	GATA4, GATA6, TFAP2C, CITED2, REN
20	cardiac septum morphogenesis	GO:060411	10.2	HAND1, HEY2, JAG1
21	atrial septum morphogenesis	GO:060413	10.1	GATA4, NKX2-5, HEY2
22	heart looping	GO:001947	10.0	VANGL2, GATA4, HAND1, NKX2-5, GJA1, MKKS
23	ventricular septum morphogenesis	GO:060412	10.0	NKX2-5, HEY2, CITED2, ZFPM2
24	cardiac right ventricle morphogenesis	GO:003215	10.0	GATA4, HEY2, JAG1
25	intracellular transport	GO:046907	10.0	BBS4, MKKS, APOE
26	right ventricular cardiac muscle tissue morphogenesis	GO:003221	10.0	NKX2-5, ZFPM2
27	negative regulation of blood pressure	GO:045776	9.9	ADIPOQ, NPY, CALCA, MKKS
28	negative regulation of gene expression	GO:010629	9.8	HEY2, GJA1, MKKS, BBS2, CITED2
29	superoxide anion generation	GO:042554	9.8	SOD1, EDN1, CYBA
30	positive regulation of cardiac muscle cell proliferation	GO:060045	9.7	HEY2, GATA6, GATA4
31	heart development	GO:007507	9.7	HAND1, NPPB, EDN1, SMYD1, TBX1, GJA1
32	vasculogenesis	GO:001570	9.7	NKX2-5, HEY2, CITED2, ZFPM2
33	regulation of blood pressure	GO:008217	9.6	NPPB, NPPA, SOD1, CALCA, REN
34	negative regulation of fat cell differentiation	GO:045599	9.4	ZFPM2, JAG1, IL6, ADIPOQ
35	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.4	GATA6, HAND1, NKX2-5, HEY2, EDN1, PKIA
36	negative regulation of transcription, DNA-dependent	GO:045892	9.1	GATA6, HAND1, ADIPOQ, NKX2-5, HEY2, SMYD1
37	response to hypoxia	GO:001666	9.0	ADIPOQ, NPPB, EDN1, CAT, MMP9, CITED2
38	response to drug	GO:042493	8.9	GATA4, GATA6, NPPB, SOD1, EDN1, ENO2
39	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.7	GATA4, GATA6, HAND1, NKX2-5, HEY2, TBX1

Molecular functions related to tetralogy of fallot according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	transcription factor binding	GO:008134	9.5	GATA6, HAND1, NKX2-5, HEY2, ZFPM2, GATA4
2	hormone activity	GO:005179	9.2	ADIPOQ, NPPB, NPPA, EDN1, CALCA
3	receptor binding	GO:005102	8.5	ADIPOQ, NPY, NPPB, NPPA, GJA1, CALCA
4	protein homodimerization activity	GO:042803	8.3	HAND1, ADIPOQ, NKX2-5, SOD1, TBX1, CAT
5	protein binding	GO:005515	4.6	GATA4, CALCA, GJA1, CYBA, SNX8, EIF3B