MCID: TTR011
MIFTS: 52

Tetraploidy malady

Rare diseases, Fetal diseases categories

Aliases & Classifications for Tetraploidy

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Sources:
42NIH Rare Diseases, 48Orphanet, 61UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Tetraploidy:

Name: Tetraploidy 42 48 61
 
Tetraploidy Syndrome 42


Classifications:



External Ids:

Orphanet48 3305
MESH via Orphanet34 D057891
ICD10 via Orphanet26 Q92.7
UMLS via Orphanet62 C0333694

Summaries for Tetraploidy

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MalaCards based summary: Tetraploidy, also known as tetraploidy syndrome, is related to myeloid leukemia and neuroblastoma, and has symptoms including microcephaly, narrow forehead and convex nasal ridge. An important gene associated with Tetraploidy is GFI1 (growth factor independent 1 transcription repressor), and among its related pathways are superoxide radicals degradation and NGF Pathway. The compounds dicoumarol and peroxynitrite have been mentioned in the context of this disorder. Affiliated tissues include myeloid, lung and skin, and related mouse phenotypes are endocrine/exocrine gland and hearing/vestibular/ear.

Related Diseases for Tetraploidy

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Diseases related to Tetraploidy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1myeloid leukemia30.3TP73, FLT3, PARP1, MYC, CDK2
2neuroblastoma30.2MYC, TP53, NGFR
3alzheimer disease29.5NGFR, PTN, SOD2, CCNB1, PLK1, CAT
4sarcoma29.4TP53, SOD2, BRCA2, TCF19, CDK2
5colorectal cancer29.2TP53, TP73, PARP1, MYC, PLK1, CDK2
6adenoma28.9TP53, TP73, PARP1, MYC, CCNB1, CDK2
7leukemia28.6GFI1, NGFR, TP53, TP73, BRCA2, ZYX
8glioblastoma28.1PLK1, CCNB1, MYC, PARP1, SOD2, TP73
9melanoma27.4PARP1, MYC, CCNB1, PLK1, CAT, CDK2
10cerebral primitive neuroectodermal tumor10.4MYC
11triploidy10.4
12neuronitis10.3
13acute leukemia10.3
14meningioma, familial10.3PTN, TP73
15myeloma10.2
16breast cancer10.2BRCA2, MYC
17precursor b-cell acute lymphoblastic leukemia10.1MYC, FLT3, TP73
18hodgkin lymphoma10.1NGFR, BRCA2, FLT3
19myelodysplastic syndrome10.1
20multiple myeloma10.1
21lymphoblastic leukemia10.1
22papillary carcinoma10.1PLK1, BRCA2, SOD2
23esophagitis10.1SOD2, CAT
24wilms tumor10.1PTN, TP73, BRCA2, FLT3
25kidney cancer10.0TP73, SOD2, FLT3, CCNB1
26li-fraumeni syndrome10.0BRCA2, TP53
27chronic lymphocytic leukemia10.0CDK2, FLT3, BRCA2
28grade iii astrocytoma10.0CCNB1, TP73, TP53
29acute lymphoblastic leukemia, childhood10.0CDK2, PARP1, FLT3
30lynch syndrome10.0TP53, BRCA2
31toxic encephalopathy10.0SOD2, PARP1, CAT
32alcoholic liver cirrhosis10.0CAT, SOD2
33anaplastic large cell lymphoma10.0
34colorectal adenoma10.0
35malt lymphoma10.0
36neutropenia10.0
37polycystic ovary syndrome10.0
38ulcerative colitis10.0
39cervicitis10.0
40colitis10.0
41colonic disease10.0
42mediastinitis10.0
43retinitis10.0
44acute myelomonocytic leukemia10.0
45hydrops fetalis10.0
46superior vena cava syndrome10.0
47hypoxia10.0
48partial hydatidiform mole10.0
49alk-positive anaplastic large cell lymphoma10.0
50ductal carcinoma in situ10.0BRCA2, TP53

Graphical network of the top 20 diseases related to Tetraploidy:



Diseases related to tetraploidy

Symptoms for Tetraploidy

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Symptoms:

 48 (show all 18)
  • microcephaly
  • narrow forehead
  • beaked nose
  • total/partial trisomy/duplication
  • stillbirth/neonatal death
  • intrauterine growth retardation
  • micrognathia/retrognathia/micrognathism/retrognathism
  • short philtrum
  • ear cartilage deficiency
  • radial club hand
  • anophthalmos/anophthalmia/microphthalmos/microphthalmia
  • cleft palate without cleft lip/submucosal cleft palate/bifid uvula
  • preauricular/branchial tags/appendages
  • hypoplastic lungs/pulmonary hypoplasia/agenesis
  • thymic aplasia/hypoplasia
  • agenesis/hypoplasia/aplasia of kidneys
  • megaureter/hydronephrosis/pyeloureteral junction syndrome
  • arnold-chiari anomaly

HPO human phenotypes related to Tetraploidy:

(show all 16)
id Description Frequency HPO Source Accession
1 microcephaly hallmark (90%) HP:0000252
2 narrow forehead hallmark (90%) HP:0000341
3 convex nasal ridge hallmark (90%) HP:0000444
4 intrauterine growth retardation hallmark (90%) HP:0001511
5 abnormality of chromosome segregation hallmark (90%) HP:0002916
6 short philtrum typical (50%) HP:0000322
7 micrognathia typical (50%) HP:0000347
8 radial club hand typical (50%) HP:0004059
9 hypoplasia of the ear cartilage typical (50%) HP:0100720
10 cleft palate occasional (7.5%) HP:0000175
11 preauricular skin tag occasional (7.5%) HP:0000384
12 arnold-chiari malformation occasional (7.5%) HP:0002308
13 aplasia/hypoplasia of the lungs occasional (7.5%) HP:0006703
14 aplasia/hypoplasia affecting the eye occasional (7.5%) HP:0008056
15 renal hypoplasia/aplasia occasional (7.5%) HP:0008678
16 aplasia/hypoplasia of the thymus occasional (7.5%) HP:0010515

Drugs & Therapeutics for Tetraploidy

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Drug clinical trials:

Search ClinicalTrials for Tetraploidy

Search NIH Clinical Center for Tetraploidy

Genetic Tests for Tetraploidy

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Anatomical Context for Tetraploidy

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MalaCards organs/tissues related to Tetraploidy:

31
Myeloid, Lung, Skin, Colon, Eye, Thymus, Kidney, Brain, Ovary, Placenta, Bone, Cortex, Cerebellum, Smooth muscle, Pancreas, Breast, B cells, Bone marrow

Animal Models for Tetraploidy or affiliated genes

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Publications for Tetraploidy

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Articles related to Tetraploidy:

(show top 50)    (show all 184)
idTitleAuthorsYear
1
Tetraploidy acute promyelocytic leuemia with double t(15;17)/PML-RARA, a case report with review of literature. (25197424)
2014
2
The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. (24775809)
2014
3
A framework genetic map for Miscanthus sinensis from RNAseq-based markers shows recent tetraploidy. (22524439)
2012
4
Reed-Sternberg-like cells of ALK-positive anaplastic large cell lymphoma with near-tetraploidy. (22250643)
2012
5
Tetraploidy with double t(11;18) of recurrent MALT lymphoma in buccal mucosa: a case report. (22669146)
2012
6
AML associated with extensive erythrophagocytosis and tetraploidy. (21790789)
2011
7
Somatic tetraploidy in vertebrate neurons: Implications in physiology and pathology. (20585523)
2010
8
Mosaic and complete tetraploidy in live-born infants: two new patients and review of the literature. (20305547)
2010
9
Near-tetraploidy clone can evolve from a hyperdiploidy clone and cause resistance to lenalidomide and bortezomib in a multiple myeloma patient. (20138360)
2010
10
Mosaicism for combined tetrasomy of chromosomes 8 and 18 in a dysmorphic child: a result of failed tetraploidy correction? (19445731)
2009
11
A reevaluation of tetraploidy in the Alzheimer's disease brain. (19738367)
2009
12
Deregulated Aurora-B induced tetraploidy promotes tumorigenesis. (19332642)
2009
13
Mosaic tetraploidy and transient GFI1 mutation in a patient with severe chronic neutropenia. (17096407)
2008
14
The consequences of tetraploidy and aneuploidy. (19020304)
2008
15
Tetraploidy and 5q deletion in myelodysplastic syndrome: a case report. (18474300)
2008
16
Tetraploidy, aneuploidy and cancer. (17324569)
2007
17
Chromosome 13q deletion and IgH abnormalities may be both masked by near-tetraploidy in a high proportion of multiple myeloma patients: a combined morphology and I-FISH analysis. (17590504)
2007
18
Tetraploidy and chromosomal instability are early events during cervical carcinogenesis. (16123119)
2006
19
Occurrence of tetraploidy in Nicotiana attenuata plants after Agrobacterium-mediated transformation is genotype specific but independent of polysomaty of explant tissue. (16518637)
2006
20
Tetraploidy and tumor development. (16286243)
2005
21
Myeloid/natural killer cell precursor acute leukemia with tetraploidy. (16337859)
2005
22
Prenatal diagnosis of a true fetal tetraploidy in direct and cultured chorionic villi. (15658618)
2004
23
Near-triploidy and near-tetraploidy in hematological malignancies and mutation of the p53 gene. (14738434)
2004
24
G2 and spindle assembly checkpoint adaptation, and tetraploidy arrest: implications for intrinsic and chemically induced genomic instability. (14643440)
2003
25
Tetraploidy in a 26-month-old girl (cytogenetic and molecular studies). (11903358)
2002
26
Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy. (11160908)
2001
27
The impact of ancestral tetraploidy on antibody heterogeneity in salmonid fishes. (9914910)
1998
28
Tetraploidy in a growth-retarded fetus with a thick placenta. (9742582)
1998
29
Transition to tetraploidy in 1,25-dihydroxyvitamin D3-resistant HL60 cells is preceded by reduced growth factor dependence and constitutive up-regulation of Sp1 and AP-1 transcription factors. (8968109)
1996
30
Unique mosaicism of tetraploidy and trisomy 8: clinical, cytogenetic, and molecular findings in a live-born infant. (8882781)
1996
31
Near-tetraploidy in adult acute myelogenous leukemia. (8603334)
1996
32
Inactivation of p53 and the development of tetraploidy in the elastase-SV40 T antigen transgenic mouse pancreas. (8577673)
1995
33
Flow cytometric DNA analysis of neuroblastoma--clinical significance of DNA tetraploidy. (7972240)
1994
34
Prenatal diagnosis of tetraploidy. (8240691)
1993
35
Correlation between in vitro tetraploidy in skin fibroblasts and development of sporadic colorectal carcinomas. (2253181)
1990
36
Tetraploidy in a liveborn infant. (2074564)
1990
37
Tetraploidy in a 15-month-old girl. (3287924)
1988
38
MCA/MR syndrome in a female infant with tetraploidy mosaicism: review of the human polyploid phenotype. (3055989)
1988
39
Genetic improvement of Egyptian henbane, Hyoscyamus muticus L. through induced tetraploidy. (24240864)
1986
40
Chromosomes and causation of human cancer and leukemia. LIV. Near-tetraploidy in acute leukemia. (3855276)
1985
41
Near-tetraploidy in acute leukemia. (6429012)
1984
42
Tetraploidy and early development: effects on developmental timing and embryonic metabolism. (6175717)
1981
43
In vitro tetraploidy in familial polyposis coli. (6105360)
1980
44
Spontaneous occurrence of tetraploidy and near-haploidy in mammalian peripheral blood. (6054022)
1967
45
Cytological evidence of constant tetraploidy in the bisexual South American frog Odontophrynus americanus. (5959682)
1966
46
Experimental tetraploidy in newts. (13575652)
1958
47
Effect of tetraploidy on learning and retention in the salamander. (13432750)
1957
48
Colchicine-induced tetraploidy in Luzula purpurea Link. (14796716)
1950
49
TETRAPLOIDY IN ANTIRRHINUM MAJUS INDUCED BY SANGUINARINE HYDROCHLORIDE. (17791279)
1942
50
Tetraploidy in Citrus. (16576911)
1925

Variations for Tetraploidy

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Expression for genes affiliated with Tetraploidy

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Search GEO for disease gene expression data for Tetraploidy.

Pathways for genes affiliated with Tetraploidy

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Pathways related to Tetraploidy according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CAT, SOD2
2
Show member pathways
9.7MYC, TP53, NGFR
3
Show member pathways
9.6MYC, TP73, TP53
4
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.6TP53, TP73, MYC
5
Show member pathways
9.6TP53, BRCA2, MYC
69.4FLT3, MYC, TP53, NGFR
79.4TP73, MYC, CDK2
8
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
9.4TP53, MYC, NGFR, TP73
99.4MYC, TP53, CCNB1
109.3CDK2, TP53, MYC
119.3CDK2, TP53, MYC
129.3CDK2, TP53, MYC
139.3TP53, MYC, CDK2
14
Show member pathways
9.3BRCA2, PLK1, TP53
15
Show member pathways
9.2SOD2, FLT3, MYC, TP53, NGFR
16
Show member pathways
Cell cycle ESR1 regulation of G1 S transition59
Immune response MIF JAB1 signaling59
Cell cycle Cell cycle generic schema 59
9.1MYC, CCNB1, CDK2
179.1TP53, NGFR, MYC, CDK2
189.1TP53, NGFR, CDK2, MYC
19
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.1TP73, TP53, CAT, MYC, SOD2
20
Show member pathways
9.1CDK2, CAT, SOD2, TP53
219.1MYC, CDK2, TP73, TP53
22
Show member pathways
9.1CDK2, CCNB1, TP53
239.1TP53, CCNB1, CDK2
249.1TP53, CCNB1, CDK2
25
Show member pathways
Signaling Pathways in Glioblastoma36
9.1BRCA2, MYC, TP53, CDK2
26
Show member pathways
9.0CCNB1, PLK1, FBXO5
27
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation59
9.0FBXO5, CDK2, PLK1
28
Show member pathways
ATM Signaling Pathway36
8.9CDK2, CCNB1, TP53, TP73
298.9BRCA2, MYC, TP53, FLT3, CDK2
308.8TP53, MYC, CCNB1, CDK2
31
Show member pathways
8.8CDK2, PLK1, CCNB1
32
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
8.7CDK2, TP53, MYC, PLK1
33
Show member pathways
DNA damage response36
8.6TP53, TP73, MYC, CCNB1, CDK2
34
Show member pathways
8.6CCNB1, CDK2, TP53, MYC, BRCA2
358.5TP53, CDK2, MYC, PLK1, BRCA2
368.5TP53, BRCA2, MYC, PLK1, CDK2
37
Show member pathways
8.5TP53, CCNB1, FBXO5, MYC, CDK2
38
Show member pathways
8.4PLK1, FBXO5, CCNB1, CDK2
398.4FBXO5, PLK1, CDK2, CCNB1
40
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
8.3CDK2, SOD2, CCNB1, PLK1, CAT
418.3CCNB1, PLK1, CDK2, CAT, SOD2
42
Show member pathways
8.3TP53, MYC, FLT3, TCF19, PTN, NGFR
438.3CCNB1, PLK1, MYC, BRCA2, CDK2
44
Show member pathways
Cell cycle36
8.2PLK1, CCNB1, MYC, TP53, CDK2
45
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I59
7.8PLK1, MYC, TP53, CCNB1, CDK2, FBXO5
46
Show member pathways
7.8TP53, CCNB1, MYC, FBXO5, CDK2, PLK1
47
Show member pathways
7.8MYC, NGFR, PTN, FLT3, TP53, TCF19
48
Show member pathways
7.6CCNB1, TP53, TP73, LATS1, BRCA2, PLK1
49
Show member pathways
7.3PTN, TP53, CDK2, BRCA2, FLT3, MYC

Compounds for genes affiliated with Tetraploidy

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Compounds related to Tetraploidy according to GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idCompoundScoreTop Affiliating Genes
1dicoumarol449.7CAT, TP53, SOD2, PARP1
2peroxynitrite449.6CAT, NGFR, PARP1, SOD2
3antimycin a449.6CAT, SOD2, PARP1
4pdtc449.5TP53, SOD2, CAT, PARP1
5cd 437449.4CDK2, TP53, PARP1, MYC
6sodium arsenite449.4CCNB1, MYC, TP53, CAT
7indole-3-carbinol449.4CDK2, PARP1, TP53, BRCA2
8methylmethanesulfonate449.3TP53, BRCA2, CDK2, PARP1
93,3-diindolylmethane449.3TP53, PARP1, CDK2
104-hydroxynonenal44 2410.3SOD2, MYC, CDK2, CAT, PARP1
11melphalan44 50 1111.2TP53, PARP1, MYC, CCNB1
12vincristine44 50 1111.2MYC, BRCA2, TP73, CCNB1, TP53
13dmso449.2CDK2, CAT, MYC, SOD2, TP73
14egcg449.1CAT, SOD2, PARP1, TP53, CDK2
15n acetylcysteine449.1TP53, SOD2, MYC, CAT, PARP1
16docetaxel44 50 60 1112.1TP53, CCNB1, MYC, PARP1, BRCA2
17silymarin449.1PARP1, CDK2, CCNB1, CAT
18curcumin449.0PARP1, CDK2, MYC, TP53, CAT, SOD2
19indomethacin44 28 60 1112.0CDK2, CAT, NGFR, SOD2, MYC
20roscovitine449.0CDK2, CCNB1, TP53, PARP1, MYC
21hydroxyurea44 50 1110.9MYC, CCNB1, TP53, BRCA2, CDK2
22adpribose448.9CCNB1, TP53, CDK2, BRCA2, PARP1
23resveratrol44 60 24 1111.9PARP1, CDK2, CCNB1, BRCA2, TP53
24lactacystin448.9MYC, CCNB1, CDK2, PARP1, TP53
25paraffin448.8TP73, NGFR, TP53, SOD2, BRCA2, MYC
26mg 13244 609.8CCNB1, MYC, PARP1, CDK2, TP53
27actinomycin d448.7TP73, SOD2, PARP1, TP53, CAT, CDK2
28imatinib44 50 1110.7MYC, TP73, PARP1, FLT3, PLK1, CDK2
29cycloheximide448.6BRCA2, TP53, SOD2, PARP1, MYC, CAT
30genistein44 28 60 1 24 1113.6CCNB1, MYC, PARP1, BRCA2, SOD2, CDK2
31zinc44 249.6SOD2, ZYX, BRCA2, CCNB1, TP73, NGFR
32agar448.5PTN, SOD2, MYC, CAT, CDK2, NGFR
33camptothecin44 60 1110.5TP53, CCNB1, TP73, MYC, BRCA2, PARP1
34arsenite44 249.5TP53, FLT3, CCNB1, CAT, MYC, CDK2
35adriamycin448.4CCNB1, SOD2, TP73, TP53, BRCA2, MYC
36butyrate448.3CDK2, SOD2, CCNB1, TP53, MYC
37ly294002448.3PARP1, PTN, TP53, MYC, SOD2, CDK2
38etoposide44 50 60 1111.3MYC, SOD2, CCNB1, TP53, BRCA2, FLT3
39cisplatin44 50 60 1111.2CDK2, MYC, PARP1, CCNB1, SOD2, BRCA2
40paclitaxel44 50 119.8BRCA2, CDK2, PLK1, CCNB1, MYC, PARP1
41estrogen447.8CDK2, PLK1, CCNB1, MYC, BRCA2, NGFR
42oligonucleotide447.8CCNB1, NGFR, GFI1, TP53, TP73, BRCA2
43threonine447.8CDK2, PLK1, CCNB1, MYC, TP73, NGFR
44h2o2447.6PARP1, CDK2, SOD2, CAT, TP53, CCNB1
45phosphatidylinositol447.4PTN, NGFR, BRCA2, FLT3, PLK1, MYC
46doxorubicin44 50 119.4TP53, MYC, PLK1, CAT, CCNB1, PARP1
47vegf447.2CDK2, TP73, TP53, SOD2, FLT3, PTN
48retinoic acid44 248.2MYC, CCNB1, NGFR, PTN, TP53, TP73
49thymidine44 248.1NGFR, CDK2, CCNB1, PLK1, BRCA2, TP53
50tyrosine446.7SOD2, ZYX, PLK1, MYC, FLT3, TP73

GO Terms for genes affiliated with Tetraploidy

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Cellular components related to Tetraploidy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1condensed nuclear chromosome outer kinetochoreGO:00009429.4CCNB1, PLK1
2spindle poleGO:00009228.9PLK1, CCNB1, LATS1
3spindleGO:00058198.9PLK1, MYC, FBXO5
4centrosomeGO:00058138.5BRCA2, CCNB1, PLK1, CDK2
5nucleolusGO:00057308.3TP53, BRCA2, PARP1, MYC, PLK1, FBXO5
6nucleoplasmGO:00056547.2CDK2, NGFR, FBXO5, TP53, BRCA2, PARP1
7cytosolGO:00058297.1NGFR, FBXO5, TP53, TP73, LATS1, CCNB1
8nucleusGO:00056346.2BRCA2, TP73, TP53, FBXO5, GFI1, ZYX

Biological processes related to Tetraploidy according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1response to hyperoxiaGO:005509310.2CAT, SOD2
2hemopoiesisGO:003009710.1SOD2, BRCA2, FLT3
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.1TP53, BRCA2, TP73
4release of cytochrome c from mitochondriaGO:000183610.1TP53, TP73, SOD2
5response to X-rayGO:001016510.0BRCA2, TP73, TP53
6intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:004277110.0TP73, BRCA2, TP53
7protein tetramerizationGO:005126210.0TP73, TP53, CAT
8negative regulation of fibroblast proliferationGO:004814710.0SOD2, TP53, MYC
9cellular response to UVGO:003464410.0MYC, TP73, TP53
10regulation of transcription involved in G1/S transition of mitotic cell cycleGO:000008310.0FBXO5, GFI1
11centrosome duplicationGO:005129810.0BRCA2, CDK2
12double-strand break repairGO:00063029.9TP53, PARP1, BRCA2
13cell cycle arrestGO:00070509.8TP73, MYC, TP53
14transforming growth factor beta receptor signaling pathwayGO:00071799.8PARP1, MYC, TP53
15mitotic G1 DNA damage checkpointGO:00315719.8TP53, CDK2, TP73
16metaphase/anaphase transition of mitotic cell cycleGO:00070919.8FBXO5, PLK1
17oocyte maturationGO:00015569.7FBXO5, BRCA2, CCNB1
18positive regulation of mitotic cell cycleGO:00459319.7BRCA2, CCNB1
19cellular response to DNA damage stimulusGO:00069749.6TP53, TP73, MYC
20cell agingGO:00075699.6TP53, BRCA2
21negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:00457369.6PLK1, LATS1
22response to gamma radiationGO:00103329.5MYC, TP73, BRCA2, TP53, SOD2
23regulation of mitotic cell cycleGO:00073469.4FBXO5, PLK1
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleGO:00514379.3PLK1, FBXO5, CCNB1
25positive regulation of transcription, DNA-templatedGO:00458939.2CDK2, MYC, BRCA2, TP73, TP53
26G1/S transition of mitotic cell cycleGO:00000829.2FBXO5, CCNB1, CDK2
27negative regulation of apoptotic processGO:00430669.1CAT, TP53, PLK1, MYC, NGFR
28negative regulation of transcription from RNA polymerase II promoterGO:00001228.9MYC, PARP1, PLK1, GFI1, TP53, TP73
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleGO:00514398.8CDK2, PLK1, CCNB1, FBXO5
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processGO:00311458.8PLK1, FBXO5, CDK2, CCNB1
31positive regulation of cell proliferationGO:00082848.8FLT3, CDK2, MYC, PTN
32G2/M transition of mitotic cell cycleGO:00000868.7LATS1, CDK2, PLK1, CCNB1
33mitotic cell cycleGO:00002788.7PLK1, CDK2, CCNB1, FBXO5

Molecular functions related to Tetraploidy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:00442129.7TP73, TP53, GFI1
2transcription factor bindingGO:00081349.2MYC, PARP1, TP73, TP53
3identical protein bindingGO:00428029.1TP53, TP73, SOD2, PARP1
4protein kinase bindingGO:00199018.0FBXO5, TP53, TP73, LATS1, CCNB1, PLK1
5protein bindingGO:00055155.6CDK2, GFI1, NGFR, FBXO5, TP53, TP73

Sources for Tetraploidy

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet