Aliases & Classifications for Tetraploidy

Summaries for Tetraploidy

MalaCards based summary : Tetraploidy, also known as tetraploidy syndrome, is related to leukemia and myeloid leukemia, and has symptoms including hydronephrosis, cleft palate and microcephaly. An important gene associated with Tetraploidy is LATS1 (Large Tumor Suppressor Kinase 1), and among its related pathways/superpathways are TNFR1 Pathway and Apoptosis Modulation and Signaling. The drugs Omeprazole and Melatonin have been mentioned in the context of this disorder. Affiliated tissues include myeloid, skin and colon, and related phenotypes are Synthetic lethal with cisplatin and cellular

Related Diseases for Tetraploidy

Diseases related to Tetraploidy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
id Related Disease Score Top Affiliating Genes
1 leukemia 10.3
2 myeloid leukemia 10.1
3 sparse hair ptosis mental retardation 10.0 LATS1 TP53
4 endocervicitis 10.0 BRCA2 TP53
5 breast pericanalicular fibroadenoma 10.0 BRCA2 TP53
6 extracranial neuroblastoma 10.0 BRCA2 TP53
7 chest wall lymphoma 10.0 BRCA2 TP53
8 retinal detachment 10.0 BRCA2 TP53
9 brenner tumor of the vagina 10.0 BRCA2 TP53
10 brenner tumor of ovary 10.0 BRCA2 TP53
11 diffuse large b-cell lymphoma 10.0 NGFR PARP1
12 triploidy 10.0
13 distal monosomy 7q36 9.9 BRCA2 TP53
14 ureter urothelial papilloma 9.9 PARP1 TP53
15 colon signet ring adenocarcinoma 9.9 BRCA2 TP53
16 neuronitis 9.9
17 mycetoma 9.9 BRCA2 TP53
18 ductal carcinoma in situ 9.9 BRCA2 TP53
19 fallopian tube carcinosarcoma 9.9 BRCA2 TP53
20 dental caries 9.9 BRCA2 TP53
21 nasal cavity disease 9.9 BRCA2 TP53
22 cellular myxoid liposarcoma 9.9 BRCA2 TP53
23 acute leukemia 9.9
24 mixed cerebral palsy 9.9 BRCA2 TP53
25 c-p angle neurinoma 9.9 NGFR TP53
26 trachea carcinoma in situ 9.9 BRCA2 TP53
27 pancreatic somatostatinoma 9.8 BRCA2 TP53
28 congenital sucrase-isomaltase deficiency without starch intolerance 9.8 NOTCH1 TP53
29 rete testis adenoma 9.8 NOTCH1 TP53
30 post-surgical hypoinsulinemia 9.8 BRCA2 TP53
31 neuroblastoma 9.8
32 colorectal cancer 9.8
33 lymphoma 9.8
34 phalanx chondroma 9.8 NOTCH1 TP53
35 bleeding disorder, platelet-type, 13 9.8 BRCA2 TP53
36 prostate adenoid cystic carcinoma 9.8 NOTCH1 TP53
37 duodenal ulcer 9.8 NOTCH1 TP53
38 childhood ovarian embryonal carcinoma 9.8 BRCA2 TP53
39 estrogen-receptor negative breast cancer 9.8 BRCA2 TP53
40 myelodysplastic syndrome 9.7
41 multiple myeloma 9.7
42 lymphoblastic leukemia 9.7
43 tracheal disease 9.7 NOTCH1 TP53
44 septicemic plague 9.6 PARP1 TP53
45 nasopharyngeal carcinoma 9.6 BRCA2 TP53
46 nail disorder, nonsyndromic congenital, 1 9.6 BRCA2 TP53
47 alzheimer disease 9.6
48 anaplastic large cell lymphoma 9.6
49 colorectal adenoma 9.6
50 neutropenia 9.6

Graphical network of the top 20 diseases related to Tetraploidy:



Diseases related to Tetraploidy

Symptoms & Phenotypes for Tetraploidy

Human phenotypes related to Tetraploidy:

56 32 (show all 17)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hydronephrosis 56 32 occasional (7.5%) Occasional (29-5%) HP:0000126
2 cleft palate 56 32 occasional (7.5%) Occasional (29-5%) HP:0000175
3 microcephaly 56 32 hallmark (90%) Very frequent (99-80%) HP:0000252
4 short philtrum 56 32 frequent (33%) Frequent (79-30%) HP:0000322
5 micrognathia 56 32 frequent (33%) Frequent (79-30%) HP:0000347
6 preauricular skin tag 56 32 occasional (7.5%) Occasional (29-5%) HP:0000384
7 convex nasal ridge 56 32 hallmark (90%) Very frequent (99-80%) HP:0000444
8 intrauterine growth retardation 56 32 hallmark (90%) Very frequent (99-80%) HP:0001511
9 arnold-chiari malformation 56 32 occasional (7.5%) Occasional (29-5%) HP:0002308
10 abnormality of chromosome segregation 56 32 hallmark (90%) Very frequent (99-80%) HP:0002916
11 radial club hand 56 32 frequent (33%) Frequent (79-30%) HP:0004059
12 biparietal narrowing 56 32 hallmark (90%) Very frequent (99-80%) HP:0004422
13 aplasia/hypoplasia of the lungs 56 32 occasional (7.5%) Occasional (29-5%) HP:0006703
14 aplasia/hypoplasia affecting the eye 56 32 occasional (7.5%) Occasional (29-5%) HP:0008056
15 renal hypoplasia/aplasia 56 32 occasional (7.5%) Occasional (29-5%) HP:0008678
16 aplasia/hypoplasia of the thymus 56 32 occasional (7.5%) Occasional (29-5%) HP:0010515
17 hypoplasia of the ear cartilage 56 32 frequent (33%) Frequent (79-30%) HP:0100720

GenomeRNAi Phenotypes related to Tetraploidy according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with cisplatin GR00101-A-1 8.62 BRCA2 NOTCH1

MGI Mouse Phenotypes related to Tetraploidy:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.99 BRCA2 NOTCH1 LATS1 PARP1 NGFR TP53
2 growth/size/body region MP:0005378 9.95 BRCA2 NOTCH1 LATS1 PARP1 NGFR TP53
3 homeostasis/metabolism MP:0005376 9.91 BRCA2 NOTCH1 LATS1 PARP1 NGFR TP53
4 integument MP:0010771 9.88 BRCA2 NOTCH1 LATS1 PARP1 NGFR TP53
5 digestive/alimentary MP:0005381 9.8 BRCA2 NOTCH1 NGFR TP53
6 mortality/aging MP:0010768 9.8 BRCA2 NOTCH1 LATS1 PARP1 NGFR TP53
7 hearing/vestibular/ear MP:0005377 9.76 NOTCH1 PARP1 NGFR TP53
8 liver/biliary system MP:0005370 9.67 NOTCH1 LATS1 NGFR TP53
9 nervous system MP:0003631 9.63 BRCA2 NOTCH1 LATS1 PARP1 NGFR TP53
10 neoplasm MP:0002006 9.56 BRCA2 NOTCH1 LATS1 TP53
11 normal MP:0002873 9.35 BRCA2 NOTCH1 LATS1 NGFR TP53
12 renal/urinary system MP:0005367 8.92 NOTCH1 PARP1 NGFR TP53

Drugs & Therapeutics for Tetraploidy

Drugs for Tetraploidy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
2
Melatonin Approved, Nutraceutical, Vet_approved Phase 3 73-31-4 896
3 Antacids Phase 3
4 Antioxidants Phase 3
5 Anti-Ulcer Agents Phase 3
6 Central Nervous System Depressants Phase 3
7 Gastrointestinal Agents Phase 3
8 Protective Agents Phase 3
9
Proton pump inhibitors Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study Unknown status NCT01566474 Phase 3 Omeprazole;Melatonin

Search NIH Clinical Center for Tetraploidy

Genetic Tests for Tetraploidy

Anatomical Context for Tetraploidy

MalaCards organs/tissues related to Tetraploidy:

39
Myeloid, Skin, Colon, Eye, Thymus, Lung, Ovary

Publications for Tetraploidy

Articles related to Tetraploidy:

(show top 50) (show all 198)
id Title Authors Year
1
Tetraploidy acute myeloid leukaemia after chromosome 16 inversion. ( 28331025 )
2017
2
The characterisation of microsatellite markers reveals tetraploidy in the Greater Water Parsnip, Sium latifolium (Apiaceae). ( 28606172 )
2017
3
BILATERAL OPTIC NERVE COLOBOMAS IN INFANT WITH TETRAPLOIDY. ( 26579595 )
2016
4
Erythrophagocytosis in T-cell type acute lymphoblastic leukaemia with near-tetraploidy. ( 27520437 )
2016
5
Aneuploidy and Tetraploidy as Distinct Patterns During Melanomagenesis. ( 27466867 )
2016
6
Effects of tetraploidy induction on rainbow trout (Oncorhynchus mykiss, Walbaum, 1792) proteome at early stages of development. ( 27561891 )
2016
7
Tetraploidy Enhances Boron-Excess Tolerance in Carrizo Citrange (Citrus sinensis L. Osb. A9 Poncirus trifoliata L. Raf.). ( 27252717 )
2016
8
A female newborn having mosaicism with near-tetraploidy and trisomy 18. ( 26789424 )
2016
9
Tetraploidy enhances the ability to exclude chloride from leaves in carrizo citrange seedlings. ( 27589221 )
2016
10
Tetraploidy/near-tetraploidy acute myeloid leukemia. ( 27951415 )
2016
11
Cytokinetic failure-induced tetraploidy develops into aneuploidy, triggering skin aging in phospho-vimentin deficient mice. ( 25847236 )
2015
12
Stimulation of Cell Elongation by Tetraploidy in Hypocotyls of Dark-Grown Arabidopsis Seedlings. ( 26244498 )
2015
13
TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer. ( 25916844 )
2015
14
Clinicopathological analysis of near-tetraploidy/tetraploidy acute myeloid leukaemia. ( 25563333 )
2015
15
Tetraploidy and CIN: a dangerous combination. ( 26517196 )
2015
16
Tetraploidy acute promyelocytic leuemia with double t(15;17)/PML-RARA, a case report with review of literature. ( 25197424 )
2014
17
Tetraploidy and tumor development. ( 25526024 )
2014
18
Somatic embryogenesis, tetraploidy, and variant leaf morphology in transgenic diploid strawberry (Fragaria vesca subspecies vesca 'Hawaii 4'). ( 24418064 )
2014
19
The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. ( 24775809 )
2014
20
Tetraploidy in hydatidiform moles. ( 23633551 )
2013
21
Cre recombinase induces DNA damage and tetraploidy in the absence of LoxP sites. ( 24280829 )
2013
22
Immunological control of cell cycle aberrations for the avoidance of oncogenesis: the case of tetraploidy. ( 23651194 )
2013
23
Genetic evidence for p75NTR-dependent tetraploidy in cortical projection neurons from adult mice. ( 23616554 )
2013
24
Tetraploidy with double t(15;17)(q22;q21) in acute promyelocytic leukaemia. ( 23250036 )
2013
25
Constitutive Cdk2 activity promotes aneuploidy while altering the spindle assembly and tetraploidy checkpoints. ( 23321641 )
2013
26
Two cases of near-tetraploidy in acute leukemias of ambiguous lineage. ( 24003431 )
2013
27
Tetraploidy with double t(11;18) of recurrent MALT lymphoma in buccal mucosa: a case report. ( 22669146 )
2012
28
Reed-Sternberg-like cells of ALK-positive anaplastic large cell lymphoma with near-tetraploidy. ( 22250643 )
2012
29
Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MRC). ( 22284693 )
2012
30
Tetraploidy in BRCA2 breast tumours. ( 22133571 )
2012
31
A framework genetic map for Miscanthus sinensis from RNAseq-based markers shows recent tetraploidy. ( 22524439 )
2012
32
Doubling the deck: Tetraploidy induces chromosome shuffling and cancer. ( 22918235 )
2012
33
Genomic landscape of the Alzheimer's disease brain: chromosome instability--aneuploidy, but not tetraploidy--mediates neurodegeneration. ( 21135562 )
2011
34
Semen analysis by electron and fluorescence microscopy in a case of partial hydatidiform mole reveals a high incidence of abnormal morphology, diploidy, and tetraploidy. ( 21354560 )
2011
35
AML associated with extensive erythrophagocytosis and tetraploidy. ( 21790789 )
2011
36
Enlarged and prominent nucleus may be indicative of tetraploidy: a laboratory study of a rare near-tetraploidy in a child patient with acute myelogenous leukemia AML-M4. ( 19816206 )
2010
37
Somatic tetraploidy in vertebrate neurons: Implications in physiology and pathology. ( 20585523 )
2010
38
Persistent telomere damage induces bypass of mitosis and tetraploidy. ( 20371347 )
2010
39
Following tetraploidy in maize, a short deletion mechanism removed genes preferentially from one of the two homologs. ( 20613864 )
2010
40
Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation. ( 20417871 )
2010
41
A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75 (NTR). ( 20436277 )
2010
42
Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. ( 20018664 )
2010
43
DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. ( 20098673 )
2010
44
Application of touch FISH in the study of mosaic tetraploidy and maternal cell contamination in pregnancy losses. ( 20676750 )
2010
45
Mosaic and complete tetraploidy in live-born infants: two new patients and review of the literature. ( 20305547 )
2010
46
Near-tetraploidy clone can evolve from a hyperdiploidy clone and cause resistance to lenalidomide and bortezomib in a multiple myeloma patient. ( 20138360 )
2010
47
The expression of the DeltaNp73beta isoform of p73 leads to tetraploidy. ( 19008096 )
2009
48
A reevaluation of tetraploidy in the Alzheimer's disease brain. ( 19738367 )
2009
49
Mosaicism for combined tetrasomy of chromosomes 8 and 18 in a dysmorphic child: a result of failed tetraploidy correction? ( 19445731 )
2009
50
Single institute study of FLT3 mutation in acute myeloid leukemia with near tetraploidy in Serbia. ( 19700852 )
2009

Variations for Tetraploidy

Expression for Tetraploidy

Search GEO for disease gene expression data for Tetraploidy.

Pathways for Tetraploidy

GO Terms for Tetraploidy

Cellular components related to Tetraploidy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.02 BRCA2 NGFR NOTCH1 PARP1 TP53

Biological processes related to Tetraploidy according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.67 BRCA2 PARP1 TP53
2 double-strand break repair via homologous recombination GO:0000724 9.52 BRCA2 PARP1
3 keratinocyte differentiation GO:0030216 9.51 LATS1 NOTCH1
4 double-strand break repair GO:0006302 9.48 BRCA2 PARP1
5 nucleotide-excision repair GO:0006289 9.46 BRCA2 TP53
6 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.43 BRCA2 TP53
7 cell aging GO:0007569 9.4 BRCA2 TP53
8 positive regulation of protein localization to nucleus GO:1900182 9.37 NGFR PARP1
9 response to X-ray GO:0010165 9.32 BRCA2 TP53
10 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 9.26 NGFR TP53
11 positive regulation of apoptotic process GO:0043065 9.26 LATS1 NGFR NOTCH1 TP53
12 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.16 BRCA2 TP53
13 response to gamma radiation GO:0010332 8.8 BRCA2 PARP1 TP53

Molecular functions related to Tetraploidy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.33 LATS1 PARP1 TP53
2 enzyme binding GO:0019899 9.13 NOTCH1 PARP1 TP53
3 estrogen receptor binding GO:0030331 8.62 LATS1 PARP1

Sources for Tetraploidy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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