MCID: TTR011
MIFTS: 41

Tetraploidy malady

Categories: Rare diseases, Fetal diseases

Aliases & Classifications for Tetraploidy

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Sources:
31ICD10 via Orphanet, 40MESH via Orphanet, 48NIH Rare Diseases, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Tetraploidy:

Name: Tetraploidy 48 54 68
 
Tetraploidy Syndrome 48

Classifications:



External Ids:

Orphanet54 ORPHA3305
MESH via Orphanet40 D057891
UMLS via Orphanet69 C0333694
ICD10 via Orphanet31 Q92.7

Summaries for Tetraploidy

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MalaCards based summary: Tetraploidy, also known as tetraploidy syndrome, is related to neuroblastoma and leukemia, and has symptoms including Array, Array and Array. An important gene associated with Tetraploidy is LATS1 (Large Tumor Suppressor Kinase 1), and among its related pathways are FOXM1 transcription factor network and BRCA1 Pathway. Affiliated tissues include myeloid, skin and colon, and related mouse phenotypes are integument and cellular.

Related Diseases for Tetraploidy

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Graphical network of the top 20 diseases related to Tetraploidy:



Diseases related to tetraploidy

Symptoms & Phenotypes for Tetraploidy

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Human phenotypes related to Tetraploidy:

 54 64 (show all 17)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hydronephrosis64 54 Occasional (29-5%) HP:0000126
2 cleft palate64 54 Occasional (29-5%) HP:0000175
3 microcephaly64 54 Very frequent (99-80%) HP:0000252
4 short philtrum64 54 Frequent (79-30%) HP:0000322
5 micrognathia64 54 Frequent (79-30%) HP:0000347
6 preauricular skin tag64 54 Occasional (29-5%) HP:0000384
7 convex nasal ridge64 54 Very frequent (99-80%) HP:0000444
8 intrauterine growth retardation64 54 Very frequent (99-80%) HP:0001511
9 arnold-chiari malformation64 54 Occasional (29-5%) HP:0002308
10 abnormality of chromosome segregation64 54 Very frequent (99-80%) HP:0002916
11 radial club hand64 54 Frequent (79-30%) HP:0004059
12 biparietal narrowing64 54 Very frequent (99-80%) HP:0004422
13 aplasia/hypoplasia of the lungs64 54 Occasional (29-5%) HP:0006703
14 aplasia/hypoplasia affecting the eye64 54 Occasional (29-5%) HP:0008056
15 renal hypoplasia/aplasia64 54 Occasional (29-5%) HP:0008678
16 aplasia/hypoplasia of the thymus64 54 Occasional (29-5%) HP:0010515
17 hypoplasia of the ear cartilage64 54 Frequent (79-30%) HP:0100720

MGI Mouse Phenotypes related to Tetraploidy according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0BRCA2, LATS1, NGFR, PARP1
2MP:00053847.9BRCA2, GFI1, LATS1, NGFR, PARP1, PLK1
3MP:00107687.9BRCA2, GFI1, LATS1, NGFR, PARP1, PLK1
4MP:00036317.6BRCA2, GFI1, LATS1, NGFR, PARP1

Drugs & Therapeutics for Tetraploidy

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Drugs for Tetraploidy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Omeprazoleapproved, investigational, vet_approvedPhase 334873590-58-64594
Synonyms:
( -)-Omeprazole
(-)-Omeprazole
(S)-(-)-Omeprazole
(S)-Omeprazole
119141-89-8
131959-78-9
172964-80-6
2,3,5-Trimethylpyridine/Omeprazole
2-(((3,5-Dimethyl-4-methoxy-2-pyridyl)methyl)sulfinyl)-5-methoxy-1H-benzimidazole
2-({[3,5-dimethyl-4-(methyloxy)pyridin-2-yl]methyl}sulfinyl)-5-(methyloxy)-1H-benzimidazole
5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
73590-58-6
AC-401
AC1L1IIJ
AGI-010
AKOS005066653
AULCER
Antra
Antra MUPS
Audazol
Aulcer
Axagon
BIDD:GT0189
BPBio1_000425
BRD-A55962179-001-04-9
BSPBio_000385
Belmazol
Bio-0888
C07324
CAS-73590-58-6
CCRIS 7099
CHEBI:519601
CHEBI:7772
CHEMBL1503
CID4594
CPD000058847
Ceprandal
D00455
DB00338
DB00736
DM-3458
Danlox
Demeprazol
Desec
Dizprazol
Dudencer
Elgam
Emeproton
Emilok
Epirazole
Erbolin
Esomeprazole
Esomperazole
Esopral
Exter
Gasec
Gastrimut
Gastroloc
Gibancer
H 168-68
H 168/68
H-168/68
H168/68
HMS1528I05
HMS1569D07
HMS2052G17
HMS2090E16
HMS2090F11
HSDB 3575
I06-0705
IDI1_032523
Indurgan
Inhibitron
Inhipump
LS-7629
Lensor
Logastric
Lomac
Losec
Losec, Omesec, Prilosec, Zegerid, Omeprazole
Lucen
MLS000069373
MLS001076112
MLS001424148
Maybridge4_002645
Mepral
Miol
Miracid
MolPort-003-666-741
MolPort-003-807-515
MolPort-003-849-702
Mopral
Morecon
NCGC00016925-01
 
NCGC00016925-02
NCGC00021522-03
NCGC00021522-04
NCGC00021522-05
Nexiam
Nexium
Nexium IV
Nilsec
Nopramin
Nuclosina
O0359
O104_SIGMA
OMEP
OMP
OMZ
Ocid
Olexin
Olit
Omapren
Omebeta
Omebeta 20
Omed
Omegast
Omepradex
Omepral
Omeprazol
Omeprazol [INN-Spanish]
Omeprazole
Omeprazole (JAN/USP/INN)
Omeprazole Pellets
Omeprazole [USAN:INN:BAN:JAN]
Omeprazole delayed-release
Omeprazole magnesium
Omeprazolum
Omeprazolum [INN-Latin]
Omeprazon
Omeprazone
Omeprol
Omesek
Omez
Omezol
Omezolan
Omid
Omisec
Omizac
Ompanyt
Ortanol
Osiren
Ozoken
Paprazol
Parizac
Pepticum
Pepticus
Peptilcer
Prazentol
Prazidec
Prazolit
Prestwick0_000493
Prestwick1_000493
Prestwick2_000493
Prestwick3_000493
Prestwick_808
Prilosec
Prilosec (TN)
Prilosec OTC
Procelac
Proclor
Prysma
Ramezol
Regulacid
Result
S1389_Selleck
SAM001246900
SAN-15
SMR000058847
SPBio_002306
STK623746
Sanamidol
Secrepina
TL8005099
Tedec Ulceral
UNII-KG60484QX9
UPCMLD-DP075
UPCMLD-DP075:001
Ulceral
Ulcesep
Ulcometion
Ulcozol
Ulcsep
Ulsen
Ultop
Ulzol
Victrix
Zefxon
Zegerid
Zepral
Zimor
Zoltum
esomeprazol
omeprazole
2
Melatoninapproved, nutraceutical, vet_approvedPhase 326873-31-4896
Synonyms:
0E2B08C1-B325-45B1-8939-6F9081EFDFA4
4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID
5-22-12-00042 (Beilstein Handbook Reference)
5-Methoxy-N-acetyltryptamine
5-methoxy-N-acetyltryptamine
73-31-4
A4039/0172195
AB00053279
AC1L1A9Q
AC1Q4F1W
AC1Q4F1X
AKOS000276269
Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- (9CI)
Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI)
Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI)
Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}
Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}
BAS 01281092
BIDD:ER0618
BPBio1_000590
BRD-K97530723-001-07-6
BRN 0205542
BSPBio_000536
BSPBio_003006
Bio-0635
C01598
CAS-73-31-4
CCRIS 3472
CHEBI:16796
CHEMBL45
CID896
ChemDiv2_003916
Circadin
D008550
D08170
DB01065
DB08189
DivK1c_000353
EINECS 200-797-7
EU-0100787
HMS1380B22
HMS1569K18
HMS1921E04
HMS2089F09
HMS501B15
HSCI1_000400
HSDB 7509
I05-0076
I10-0345
IDI1_000353
IDI1_002631
IN1244
KBio1_000353
KBio2_000665
KBio2_003233
KBio2_005801
KBio3_002226
KBioGR_000591
KBioSS_000665
L001261
LS-1623
Lopac-M-5250
Lopac0_000787
M 5250
M-1200
M-1250
M1105
M5250_SIGMA
ML1
MLS000859594
MLS001055382
MLS001240204
MT6
Mela-T
Melapure
Melatol
Melatonex
Melatonex, Melatonin
Melatonin
Melatonin (synth.) standard-grade
 
Melatonin (synth.) ultra-pure
Melatonina
Melatonina (TN)
Melatonine
Melovine
MolPort-000-737-883
N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)-Acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide
N-Acetyl-5-methoxy-tryptamine
N-Acetyl-5-methoxy-tryptamine Melatonine
N-Acetyl-5-methoxytryptamine
N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide
N-[2-(5-methoxyindol-3-yl)ethyl]acetamide
N-acetyl-5-methoxy-tryptamine
NCGC00015680-01
NCGC00015680-02
NCGC00015680-03
NCGC00015680-06
NCGC00015680-13
NCGC00090727-01
NCGC00090727-02
NCGC00090727-03
NCGC00090727-04
NCGC00090727-05
NCGC00090727-06
NCGC00090727-07
NCGC00090727-08
NCGC00090727-09
NCI60_004378
NINDS_000353
NMR/14327425
NSC 113928
NSC113928
NSC56423
Nature'S Harmony
Night Rest
Oprea1_104553
Oprea1_814234
PREVENTION 1 (MELATONIN) (PREVENTION 1)
PREVENTION 2 (MELATONIN)
PREVENTION 3 (MELATONIN)
PREVENTION 4 (MELATONIN)
PREVENTION 5 (MELATONIN)
Pineal Hormone
Posidorm
Prestwick0_000458
Prestwick1_000458
Prestwick2_000458
Prestwick3_000458
Prestwick_312
Regulin
Revital Melatonin
Rx Balance
S1204_Selleck
SDCCGMLS-0065812.P001
SDCCGMLS-0065812.P002
SMP2_000309
SMR000326666
SPBio_001527
SPBio_002475
SPECTRUM1500690
STK386880
Sleep Right
Spectrum2_001344
Spectrum3_001393
Spectrum4_000066
Spectrum5_001745
Spectrum_000185
TNP00300
UNII-JL5DK93RCL
Vivitas
WLN: T56 BMJ D2MV1 GO1
ZINC00057060
{N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} Acetamide
{N-[2-(5-methoxyindol-3-yl)ethyl]-} Acetamide
3
Proton pump inhibitorsPhase 31123
Synonyms:
 
PPIs
4Protective AgentsPhase 37443
5Gastrointestinal AgentsPhase 38402
6AntioxidantsPhase 33050
7Anti-Ulcer AgentsPhase 31842
8Central Nervous System DepressantsPhase 313403
9AntacidsPhase 31842

Interventional clinical trials:

idNameStatusNCT IDPhase
1Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot StudyUnknown statusNCT01566474Phase 3

Search NIH Clinical Center for Tetraploidy

Genetic Tests for Tetraploidy

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Anatomical Context for Tetraploidy

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MalaCards organs/tissues related to Tetraploidy:

36
Myeloid, Skin, Colon, Thymus, Lung, Eye, Ovary

Publications for Tetraploidy

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Articles related to Tetraploidy:

(show top 50)    (show all 196)
idTitleAuthorsYear
1
Tetraploidy Enhances Boron-Excess Tolerance in Carrizo Citrange (Citrus sinensis L. Osb. A9 Poncirus trifoliata L. Raf.). (27252717)
2016
2
Effects of tetraploidy induction on rainbow trout (Oncorhynchus mykiss, Walbaum, 1792) proteome at early stages of development. (27561891)
2016
3
Tetraploidy enhances the ability to exclude chloride from leaves in carrizo citrange seedlings. (27589221)
2016
4
Erythrophagocytosis in T-cell type acute lymphoblastic leukaemia with near-tetraploidy. (27520437)
2016
5
A female newborn having mosaicism with near-tetraploidy and trisomy 18. (26789424)
2016
6
Tetraploidy/near-tetraploidy acute myeloid leukemia. (27951415)
2016
7
BILATERAL OPTIC NERVE COLOBOMAS IN INFANT WITH TETRAPLOIDY. (26579595)
2016
8
Aneuploidy and Tetraploidy as Distinct Patterns During Melanomagenesis. (27466867)
2016
9
Stimulation of Cell Elongation by Tetraploidy in Hypocotyls of Dark-Grown Arabidopsis Seedlings. (26244498)
2015
10
Tetraploidy and CIN: a dangerous combination. (26517196)
2015
11
Clinicopathological analysis of near-tetraploidy/tetraploidy acute myeloid leukaemia. (25563333)
2015
12
Cytokinetic failure-induced tetraploidy develops into aneuploidy, triggering skin aging in phospho-vimentin deficient mice. (25847236)
2015
13
TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer. (25916844)
2015
14
The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. (24775809)
2014
15
Tetraploidy and tumor development. (25526024)
2014
16
Tetraploidy acute promyelocytic leuemia with double t(15;17)/PML-RARA, a case report with review of literature. (25197424)
2014
17
Somatic embryogenesis, tetraploidy, and variant leaf morphology in transgenic diploid strawberry (Fragaria vesca subspecies vesca 'Hawaii 4'). (24418064)
2014
18
Cre recombinase induces DNA damage and tetraploidy in the absence of LoxP sites. (24280829)
2013
19
Immunological control of cell cycle aberrations for the avoidance of oncogenesis: the case of tetraploidy. (23651194)
2013
20
Constitutive Cdk2 activity promotes aneuploidy while altering the spindle assembly and tetraploidy checkpoints. (23321641)
2013
21
Tetraploidy with double t(15;17)(q22;q21) in acute promyelocytic leukaemia. (23250036)
2013
22
Genetic evidence for p75NTR-dependent tetraploidy in cortical projection neurons from adult mice. (23616554)
2013
23
Tetraploidy in hydatidiform moles. (23633551)
2013
24
Two cases of near-tetraploidy in acute leukemias of ambiguous lineage. (24003431)
2013
25
Tetraploidy in BRCA2 breast tumours. (22133571)
2012
26
Doubling the deck: Tetraploidy induces chromosome shuffling and cancer. (22918235)
2012
27
Tetraploidy with double t(11;18) of recurrent MALT lymphoma in buccal mucosa: a case report. (22669146)
2012
28
Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MRC). (22284693)
2012
29
A framework genetic map for Miscanthus sinensis from RNAseq-based markers shows recent tetraploidy. (22524439)
2012
30
Reed-Sternberg-like cells of ALK-positive anaplastic large cell lymphoma with near-tetraploidy. (22250643)
2012
31
Genomic landscape of the Alzheimer's disease brain: chromosome instability--aneuploidy, but not tetraploidy--mediates neurodegeneration. (21135562)
2011
32
Semen analysis by electron and fluorescence microscopy in a case of partial hydatidiform mole reveals a high incidence of abnormal morphology, diploidy, and tetraploidy. (21354560)
2011
33
AML associated with extensive erythrophagocytosis and tetraploidy. (21790789)
2011
34
Enlarged and prominent nucleus may be indicative of tetraploidy: a laboratory study of a rare near-tetraploidy in a child patient with acute myelogenous leukemia AML-M4. (19816206)
2010
35
A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75 (NTR). (20436277)
2010
36
Mosaic and complete tetraploidy in live-born infants: two new patients and review of the literature. (20305547)
2010
37
Somatic tetraploidy in vertebrate neurons: Implications in physiology and pathology. (20585523)
2010
38
Application of touch FISH in the study of mosaic tetraploidy and maternal cell contamination in pregnancy losses. (20676750)
2010
39
Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. (20018664)
2010
40
Persistent telomere damage induces bypass of mitosis and tetraploidy. (20371347)
2010
41
Near-tetraploidy clone can evolve from a hyperdiploidy clone and cause resistance to lenalidomide and bortezomib in a multiple myeloma patient. (20138360)
2010
42
DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. (20098673)
2010
43
Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation. (20417871)
2010
44
Following tetraploidy in maize, a short deletion mechanism removed genes preferentially from one of the two homologs. (20613864)
2010
45
Degenerate tetraploidy was established before bdelloid rotifer families diverged. (18996928)
2009
46
Single institute study of FLT3 mutation in acute myeloid leukemia with near tetraploidy in Serbia. (19700852)
2009
47
A reevaluation of tetraploidy in the Alzheimer's disease brain. (19738367)
2009
48
A non-mosaic tetraploidy in the long-term culture of chorionic villi with a trisomy 13 in concomitant amniocytes. (19222025)
2009
49
Mosaicism for combined tetrasomy of chromosomes 8 and 18 in a dysmorphic child: a result of failed tetraploidy correction? (19445731)
2009
50
Tetraploidy triggers mitochondria. (19377300)
2009

Variations for Tetraploidy

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Expression for genes affiliated with Tetraploidy

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Search GEO for disease gene expression data for Tetraploidy.

Pathways for genes affiliated with Tetraploidy

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GO Terms for genes affiliated with Tetraploidy

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Cellular components related to Tetraploidy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1microtubule organizing centerGO:00058159.6BRCA2, LATS1, PLK1
2spindle poleGO:00009229.5LATS1, PLK1

Biological processes related to Tetraploidy according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cytokinesisGO:000091010.1BRCA2, PLK1
2negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:004573610.1LATS1, PLK1
3hemopoiesisGO:003009710.0BRCA2, GFI1
4double-strand break repairGO:00063029.8BRCA2, PARP1
5negative regulation of neuron projection developmentGO:00109779.8GFI1, NGFR
6double-strand break repair via homologous recombinationGO:00007249.8BRCA2, PARP1
7cell cycleGO:00070499.7BRCA2, LATS1, PLK1
8response to gamma radiationGO:00103329.2BRCA2, PARP1
9positive regulation of protein localization to nucleusGO:19001828.9NGFR, PARP1, PLK1

Molecular functions related to Tetraploidy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1estrogen receptor bindingGO:00303319.9LATS1, PARP1
2protein kinase bindingGO:00199018.7LATS1, PARP1, PLK1

Sources for Tetraploidy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet