MCID: TTR011
MIFTS: 48

Tetraploidy malady

Categories: Rare diseases, Fetal diseases

Aliases & Classifications for Tetraploidy

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Sources:
45NIH Rare Diseases, 51Orphanet, 65UMLS, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Tetraploidy:

Name: Tetraploidy 45 51 65
 
Tetraploidy Syndrome 45

Classifications:



External Ids:

Orphanet51 3305
ICD10 via Orphanet28 Q92.7
MESH via Orphanet37 D057891
UMLS via Orphanet66 C0333694
UMLS65 C0333694

Summaries for Tetraploidy

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MalaCards based summary: Tetraploidy, also known as tetraploidy syndrome, is related to cystadenoma and prostate cancer, and has symptoms including microcephaly, narrow forehead and convex nasal ridge. An important gene associated with Tetraploidy is LATS1 (Large Tumor Suppressor Kinase 1), and among its related pathways are DNA damage_Role of Brca1 and Brca2 in DNA repair and . Affiliated tissues include lung, skin and endothelial, and related mouse phenotypes are hearing/vestibular/ear and endocrine/exocrine gland.

Related Diseases for Tetraploidy

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Diseases related to Tetraploidy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1cystadenoma30.3BRCA1, BRCA2, TP53
2prostate cancer29.0BRCA1, BRCA2, CCNB1, CDK2, PARP1, PLK1
3breast cancer28.4AURKA, BRCA1, BRCA2, CCNB1, CDK2, PARP1
4congenital pulmonary veins atresia or stenosis10.4BRCA1, BRCA2
5bronchiolitis obliterans10.4BRCA1, BRCA2
6urethra inverted papilloma10.3PARP1, TP53
7autoimmune polyendocrine syndrome type 110.3BRCA1, BRCA2
8autoimmune disease of urogenital tract10.3BRCA1, BRCA2
9malignant testicular leydig cell tumor10.3BRCA1, BRCA2
10breast cancer, childhood10.3BRCA1, BRCA2
11brca2 hereditary breast and ovarian cancer syndrome10.3BRCA1, BRCA2
12endometrial mucinous adenocarcinoma10.3BRCA1, BRCA2, TP53
13blepharochalasis10.3CAT, SOD2, TP53
14internal auditory canal lipoma10.3BRCA1, BRCA2, TP53
15peritoneal cystic mesothelioma10.3BRCA1, BRCA2, TP53
16pancreatic cancer 410.3BRCA1, BRCA2
17fallopian tube leiomyosarcoma10.3BRCA1, BRCA2, TP53
18lymphatic system cancer10.3BRCA1, BRCA2, TP53
19uterine carcinosarcoma10.3BRCA1, BRCA2, TP53
20mutiple parosteal osteochondromatous proliferations10.3BRCA1, BRCA2, TP53
21eye carcinoma in situ10.3BRCA1, BRCA2, TP53
22vascular dementia10.3BRCA1, BRCA2, TP53
23ovary epithelial cancer10.2BRCA1, BRCA2, TP53
24ovarian wilms' cancer10.2BRCA1, BRCA2, TP53
25spondyloepimetaphyseal dysplasia, sponastrime type10.2BRCA1, BRCA2, TP53
26estrogen-receptor positive breast cancer10.2BRCA1, BRCA2, TP53
27periocular meningioma10.2BRCA1, BRCA2, TP53
28familial capillaro-venous leptomeningeal angiomatosis10.2BRCA1, BRCA2, TP53
29tracheal lymphoma10.2BRCA1, BRCA2, TP53
30hypothalamic disease10.2BRCA1, BRCA2, TP53
31renal cell carcinoma10.2
32prostatitis10.2
33endogenous depression10.2
34meningitis10.2
35mastitis10.2BRCA1, BRCA2
36pancreatic serous cystadenocarcinoma10.2BRCA1, BRCA2, TP53, TP73
37vulvar alveolar soft part sarcoma10.1BRCA1, BRCA2
38choroid plexus papilloma10.1BRCA1, BRCA2, TP53
39medulloblastoma10.1BRCA2, NGFR, TP53, TP73
40schizophrenia10.1
41hypoplastic left heart syndrome10.1
42rheumatic heart disease10.1
43focal dystonia10.1
44lymphoma10.1
45heart disease10.1
46constrictive pericarditis10.1
47personality disorder10.1
48pericarditis10.1
49cervicitis10.1
50adenocarcinoma10.1

Graphical network of the top 20 diseases related to Tetraploidy:



Diseases related to tetraploidy

Symptoms for Tetraploidy

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Symptoms:

 51 (show all 18)
  • microcephaly
  • narrow forehead
  • beaked nose
  • total/partial trisomy/duplication
  • stillbirth/neonatal death
  • intrauterine growth retardation
  • micrognathia/retrognathia/micrognathism/retrognathism
  • short philtrum
  • ear cartilage deficiency
  • radial club hand
  • anophthalmos/anophthalmia/microphthalmos/microphthalmia
  • cleft palate without cleft lip/submucosal cleft palate/bifid uvula
  • preauricular/branchial tags/appendages
  • hypoplastic lungs/pulmonary hypoplasia/agenesis
  • thymic aplasia/hypoplasia
  • agenesis/hypoplasia/aplasia of kidneys
  • megaureter/hydronephrosis/pyeloureteral junction syndrome
  • arnold-chiari anomaly

HPO human phenotypes related to Tetraploidy:

(show all 16)
id Description Frequency HPO Source Accession
1 microcephaly hallmark (90%) HP:0000252
2 narrow forehead hallmark (90%) HP:0000341
3 convex nasal ridge hallmark (90%) HP:0000444
4 intrauterine growth retardation hallmark (90%) HP:0001511
5 abnormality of chromosome segregation hallmark (90%) HP:0002916
6 short philtrum typical (50%) HP:0000322
7 micrognathia typical (50%) HP:0000347
8 radial club hand typical (50%) HP:0004059
9 hypoplasia of the ear cartilage typical (50%) HP:0100720
10 cleft palate occasional (7.5%) HP:0000175
11 preauricular skin tag occasional (7.5%) HP:0000384
12 arnold-chiari malformation occasional (7.5%) HP:0002308
13 aplasia/hypoplasia of the lungs occasional (7.5%) HP:0006703
14 aplasia/hypoplasia affecting the eye occasional (7.5%) HP:0008056
15 renal hypoplasia/aplasia occasional (7.5%) HP:0008678
16 aplasia/hypoplasia of the thymus occasional (7.5%) HP:0010515

Drugs & Therapeutics for Tetraploidy

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Drugs for Tetraploidy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Omeprazoleapproved, investigationalPhase 332173590-58-64594
Synonyms:
( -)-Omeprazole
(-)-Omeprazole
(S)-(-)-Omeprazole
(S)-Omeprazole
119141-89-8
131959-78-9
172964-80-6
2,3,5-Trimethylpyridine/Omeprazole
2-(((3,5-Dimethyl-4-methoxy-2-pyridyl)methyl)sulfinyl)-5-methoxy-1H-benzimidazole
2-({[3,5-dimethyl-4-(methyloxy)pyridin-2-yl]methyl}sulfinyl)-5-(methyloxy)-1H-benzimidazole
5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
73590-58-6
AC-401
AC1L1IIJ
AGI-010
AKOS005066653
AULCER
Antra
Antra MUPS
Audazol
Aulcer
Axagon
BIDD:GT0189
BPBio1_000425
BRD-A55962179-001-04-9
BSPBio_000385
Being Well Omeprazole
Belmazol
Bio-0888
C07324
CAS-73590-58-6
CCRIS 7099
CHEBI:519601
CHEBI:7772
CHEMBL1503
CID4594
CPD000058847
Care One Omeprazole
Ceprandal
D00455
DB00338
DB00736
DM-3458
Danlox
Demeprazol
Desec
Dg Health Omeprazole
Dizprazol
Dudencer
Elgam
Emeproton
Emilok
Epirazole
Equaline Omeprazole
Equate Omeprazole Delayed Release acid reducer
Erbolin
Esomeprazole
Esomperazole
Esopral
Exchange Select Omeprazole
Exter
Family Wellness Omeprazole
Formu Care Omeprazole
Fulton Street Market Omeprazole
Gasec
Gastrimut
Gastroloc
Gibancer
Good Neighbor Pharmacy Omeprazole
Good Sense Omeprazole
H 168-68
H 168/68
H-168/68
H168/68
HMS1528I05
HMS1569D07
HMS2052G17
HMS2090E16
HMS2090F11
HSDB 3575
Harmon Face Values Omeprazole
Health Mart Omeprazole
Healthy Accents Omeprazole
I06-0705
IDI1_032523
Indurgan
Inhibitron
Inhipump
Kirkland Signature Omeprazole
LS-7629
Leader Omeprazole
Lensor
Logastric
Lomac
Losec
Losec, Omesec, Prilosec, Zegerid, Omeprazole
Lucen
MLS000069373
MLS001076112
MLS001424148
Maybridge4_002645
Members Mark Omeprazole
Mepral
Miol
Miracid
MolPort-003-666-741
MolPort-003-807-515
MolPort-003-849-702
Mopral
 
Morecon
NCGC00016925-01
NCGC00016925-02
NCGC00021522-03
NCGC00021522-04
NCGC00021522-05
Nexiam
Nexium
Nexium IV
Nilsec
Nopramin
Nuclosina
O0359
O104_SIGMA
OMEP
OMP
OMZ
Ocid
Olex
Olexin
Olit
Omapren
Omebeta
Omebeta 20
Omed
Omegast
Omepradex
Omepral
Omeprazol
Omeprazol [INN-Spanish]
Omeprazole
Omeprazole (JAN/USP/INN)
Omeprazole Delayed Release
Omeprazole Delayed-release
Omeprazole Magnesium
Omeprazole Pellets
Omeprazole [USAN:INN:BAN:JAN]
Omeprazole delayed-release
Omeprazole magnesium
Omeprazole sodium
Omeprazolum
Omeprazolum [INN-Latin]
Omeprazon
Omeprazone
Omeprol
Omesec
Omesek
Omez
Omezol
Omezolan
Omid
Omisec
Omizac
Ompanyt
Ortanol
Osiren
Ozoken
Paprazol
Parizac
Pepticum
Pepticus
Peptilcer
Prazentol
Prazidec
Prazolit
Preferred Plus Omeprazole
Prestwick0_000493
Prestwick1_000493
Prestwick2_000493
Prestwick3_000493
Prestwick_808
Prilosec
Prilosec (TN)
Prilosec OTC
Procelac
Proclor
Prysma
Quality Choice Omeprazole
Ramezol
Regulacid
Result
S1389_Selleck
SAM001246900
SAN-15
SMR000058847
SPBio_002306
STK623746
Sanamidol
Secrepina
Shoprite Omeprazole
Simply Right Omeprazole
Smart Sense Omeprazole
Sunmark Omeprazole
TL8005099
Tedec Ulceral
Topcare Omeprazole
UNII-KG60484QX9
UPCMLD-DP075
UPCMLD-DP075:001
Ulceral
Ulcesep
Ulcometion
Ulcozol
Ulcsep
Ulsen
Ultop
Ulzol
Victrix
Zefxon
Zegerid
Zepral
Zimor
Zoltum
esomeprazol
omeprazole
2
Melatoninapproved, nutraceuticalPhase 323473-31-4896
Synonyms:
0E2B08C1-B325-45B1-8939-6F9081EFDFA4
4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID
5-22-12-00042 (Beilstein Handbook Reference)
5-Methoxy-N-acetyltryptamine
5-methoxy-N-acetyltryptamine
73-31-4
A4039/0172195
AB00053279
AC1L1A9Q
AC1Q4F1W
AC1Q4F1X
AKOS000276269
Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- (9CI)
Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI)
Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI)
Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}
Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}
BAS 01281092
BIDD:ER0618
BPBio1_000590
BRD-K97530723-001-07-6
BRN 0205542
BSPBio_000536
BSPBio_003006
Bio-0635
C01598
CAS-73-31-4
CCRIS 3472
CHEBI:16796
CHEMBL45
CID896
ChemDiv2_003916
Circadin
D008550
D08170
DB01065
DB08189
DivK1c_000353
EINECS 200-797-7
EU-0100787
HMS1380B22
HMS1569K18
HMS1921E04
HMS2089F09
HMS501B15
HSCI1_000400
HSDB 7509
I05-0076
I10-0345
IDI1_000353
IDI1_002631
IN1244
KBio1_000353
KBio2_000665
KBio2_003233
KBio2_005801
KBio3_002226
KBioGR_000591
KBioSS_000665
L001261
LS-1623
Lopac-M-5250
Lopac0_000787
M 5250
M-1200
M-1250
M1105
M5250_SIGMA
ML1
MLS000859594
MLS001055382
MLS001240204
MT6
Mela-T
Melapure
Melatol
Melatonex
Melatonex, Melatonin
Melatonin
Melatonin (synth.) standard-grade
 
Melatonin (synth.) ultra-pure
Melatonina
Melatonina (TN)
Melatonine
Melovine
MolPort-000-737-883
N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)-Acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide
N-Acetyl-5-methoxy-tryptamine
N-Acetyl-5-methoxy-tryptamine Melatonine
N-Acetyl-5-methoxytryptamine
N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide
N-[2-(5-methoxyindol-3-yl)ethyl]acetamide
N-acetyl-5-methoxy-tryptamine
NCGC00015680-01
NCGC00015680-02
NCGC00015680-03
NCGC00015680-06
NCGC00015680-13
NCGC00090727-01
NCGC00090727-02
NCGC00090727-03
NCGC00090727-04
NCGC00090727-05
NCGC00090727-06
NCGC00090727-07
NCGC00090727-08
NCGC00090727-09
NCI60_004378
NINDS_000353
NMR/14327425
NSC 113928
NSC113928
NSC56423
Nature'S Harmony
Night Rest
Oprea1_104553
Oprea1_814234
PREVENTION 1 (MELATONIN) (PREVENTION 1)
PREVENTION 2 (MELATONIN)
PREVENTION 3 (MELATONIN)
PREVENTION 4 (MELATONIN)
PREVENTION 5 (MELATONIN)
Pineal Hormone
Posidorm
Prestwick0_000458
Prestwick1_000458
Prestwick2_000458
Prestwick3_000458
Prestwick_312
Regulin
Revital Melatonin
Rx Balance
S1204_Selleck
SDCCGMLS-0065812.P001
SDCCGMLS-0065812.P002
SMP2_000309
SMR000326666
SPBio_001527
SPBio_002475
SPECTRUM1500690
STK386880
Sleep Right
Spectrum2_001344
Spectrum3_001393
Spectrum4_000066
Spectrum5_001745
Spectrum_000185
TNP00300
UNII-JL5DK93RCL
Vivitas
WLN: T56 BMJ D2MV1 GO1
ZINC00057060
{N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} Acetamide
{N-[2-(5-methoxyindol-3-yl)ethyl]-} Acetamide
3
Proton pump inhibitorsPhase 3958
Synonyms:
 
PPIs
4Protective AgentsPhase 35651
5Gastrointestinal AgentsPhase 36401
6AntioxidantsPhase 32442
7Anti-Ulcer AgentsPhase 31453
8Central Nervous System DepressantsPhase 310016
9AntacidsPhase 31453

Interventional clinical trials:

idNameStatusNCT IDPhase
1Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot StudyRecruitingNCT01566474Phase 3

Search NIH Clinical Center for Tetraploidy

Genetic Tests for Tetraploidy

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Anatomical Context for Tetraploidy

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MalaCards organs/tissues related to Tetraploidy:

33
Lung, Skin, Endothelial, Eye, Thymus, Kidney, Prostate

Animal Models for Tetraploidy or affiliated genes

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MGI Mouse Phenotypes related to Tetraploidy:

38 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.8GFI1, NGFR, PARP1, PTN, SOD2, TP53
2MP:00053798.8BRCA1, BRCA2, CDK2, FLT3, GFI1, LATS1
3MP:00107718.3AURKB, BRCA1, BRCA2, CDK2, LATS1, NGFR
4MP:00036318.1BRCA1, BRCA2, GFI1, LATS1, NGFR, PARP1
5MP:00053897.8AURKB, BRCA1, BRCA2, CDK2, LATS1, PARP1
6MP:00053807.5AURKA, AURKB, BRCA1, BRCA2, CDK2, FBXO5
7MP:00053877.4BRCA1, BRCA2, CDK2, FLT3, GFI1, NGFR
8MP:00020067.3AURKA, AURKB, BRCA1, BRCA2, CAT, CDK2
9MP:00053786.9AURKA, AURKB, BRCA1, BRCA2, CDK2, FLT3
10MP:00053976.6BRCA1, BRCA2, CDK2, FLT3, GFI1, NGFR
11MP:00053766.0AURKB, BRCA1, BRCA2, CAT, CDK2, FLT3
12MP:00107685.7AURKA, AURKB, BRCA1, BRCA2, CAT, CDK2
13MP:00053845.3AURKA, AURKB, BRCA1, BRCA2, CAT, CDK2

Publications for Tetraploidy

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Articles related to Tetraploidy:

(show top 50)    (show all 188)
idTitleAuthorsYear
1
Meningoencephalitis due to the amoeboflagellate Naegleria fowleri in ruminants in Algeria. (26979770)
2016
2
Ollier disease in a 6-year-old child. (25899516)
2015
3
Analysis of operative efficacy for giant pituitary adenoma. (25163653)
2014
4
A variant within intron 1 of the PTPN22 gene decreases the genetic susceptibility of ankylosing spondylitis in a central south Chinese Han population. (24749936)
2014
5
Autocrine impact of VEGF-A on uveal melanoma cells. (24677103)
2014
6
Construction of protein profile classification model and screening of proteomic signature of acute leukemia. (25337199)
2014
7
Clinical features and outcomes of foot keloids treated using complete surgical excision and full thickness skin grafting followed by corticosteroid injections. (23856363)
2013
8
Coronary Artery Bypass Grafting in a Patient with Polyarteritis Nodosa Presenting with Acute Myocardial Infarction and Multiple Coronary Aneurysms. (23995351)
2013
9
Syndecan-1 (CD138) contributes to prostate cancer progression by stabilizing tumour-initiating cells. (24549646)
2013
10
Targeted drug delivery to treat pain and cerebral hypoxia. (23343976)
2013
11
Sirolimus: a switch option for mycophenolate mofetil-induced leukopenia in renal transplant recipients. (24157014)
2013
12
Apoptotic effect of dibenzylideneacetone on oral cancer cells via modulation of specificity protein 1 and Bax. (23305452)
2013
13
Phase II study of whole brain radiotherapy with or without erlotinib in patients with multiple brain metastases from lung adenocarcinoma. (24133369)
2013
14
A critical role for proinflammatory behavior of smooth muscle cells in hemodynamic initiation of intracranial aneurysm. (24023941)
2013
15
Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosis. (24363970)
2013
16
Galsulfase (NaglazymeAr) therapy in infants with mucopolysaccharidosis VI. (24108527)
2013
17
Left ventricular assist device, heparin-induced thrombocytopenia, and thrombus formation. (22186463)
2012
18
Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the disease. (22747838)
2012
19
Screening for acromegaly by application of a simple questionnaire evaluating the enlargement of extremities in adult patients seen at primary health care units. (21380935)
2012
20
Efficacy, tolerability, and immunogenicity of onabotulinumtoxina in a randomized, double-blind, placebo-controlled trial for cervical dystonia. (22948497)
2012
21
Benznidazole shortage makes chagas disease a neglected tropical disease in developed countries: data from Spain. (22826485)
2012
22
Characterization of management and outcomes of patients with acromegaly in Vancouver over 30 years. (22309962)
2012
23
Binding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication. (22761374)
2012
24
The natural history and diagnosis of idiopathic pulmonary fibrosis: are we all on the same page? (21729885)
2011
25
Retinoblastoma in patients with regressed retinopathy of prematurity. (22011498)
2011
26
Dihydropyrimidine dehydrogenase mRNA expression in peripheral blood of rectal cancer patients is significantly associated with residual tumor and distant metastases following resection. (19180589)
2009
27
Collapsing focal segmental glomerulosclerosis in a liver transplant recipient on alendronate. (17404782)
2007
28
Pedicle torsion of ovarian cyst and acupuncture--a case report. (17013361)
2006
29
The associations between gingival crevice fluid matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and periodontitis in human immunodeficiency virus-positive patients. (17076772)
2006
30
Echocardiography in chronic thromboembolic pulmonary hypertension. (17185185)
2006
31
Gender-specific association of insertion/deletion polymorphisms in the nogo gene and chronic schizophrenia. (15953657)
2005
32
Suppression of early atherosclerosis in LDL-receptor deficient mice by oral tolerance with beta 2-glycoprotein I. (15158153)
2004
33
Leptin and hypothalamus-hypophysis-thyroid axis]. (15147079)
2004
34
Constitutively and autonomously active protein kinase C associated with 14-3-3 zeta in the rodent brain. (12485398)
2003
35
Selective requirements for histone H3 and H4 N termini in p300-dependent transcriptional activation from chromatin. (11983172)
2002
36
Schistosomiasis: a critical review. (11148754)
2001
37
Gastroprotective and vasodilatory effects of epidermal growth factor: the role of sensory afferent neurons. (11292598)
2001
38
NMR structures of three single-residue variants of the human prion protein. (10900000)
2000
39
Phenotyping of immune cell infiltrates in breast and colorectal tumours. (10073680)
1999
40
A recombinant trimeric surfactant protein D carbohydrate recognition domain inhibits respiratory syncytial virus infection in vitro and in vivo. (10556802)
1999
41
The xenopus Suc1/Cks protein promotes the phosphorylation of G(2)/M regulators. (10601234)
1999
42
Mechanism of action of a tyrphostin, 3,4-dihydroxy-alpha-cyanothiocinnamamide, in breast cancer cell growth inhibition involves the suppression of cyclin B1 and the functional activity of cyclin B1/p34cdc2 complex. (9164677)
1997
43
Regulation of insulin secretion by phospholipase C. (8843732)
1996
44
Knobloch syndrome in a large Brazilian consanguineous family: confirmation of autosomal recessive inheritance. (7802003)
1994
45
Chronic rash associated with congenital rubella. (8182685)
1994
46
Clinical otosclerosis and auditory exostoses in ancient Europeans (investigation of Lithuanian paleoosteological samples). (8345295)
1993
47
Atherosclerosis: the risk factors]. (1493667)
1992
48
Indirect evidence of bronchial inflammation assessed by titration of inflammatory mediators in BAL fluid of patients with asthma. (1918730)
1991
49
Progeria (Hutchinson-Gilford). (4265458)
1973
50
Case of Facial Hemiatrophy. (19984475)
1925

Variations for Tetraploidy

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Expression for genes affiliated with Tetraploidy

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Search GEO for disease gene expression data for Tetraploidy.

Pathways for genes affiliated with Tetraploidy

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Pathways related to Tetraploidy according to GeneCards Suite gene sharing:

(show all 32)
idSuper pathwaysScoreTop Affiliating Genes
19.6BRCA1, BRCA2, TP53
2
Show member pathways
9.5BRCA1, BRCA2, TP53
39.5CCNB1, CDK2, TP53
4
Show member pathways
9.5CCNB1, CDK2, PLK1
59.5BRCA1, CDK2, TP73
69.5BRCA1, CDK2, TP53
79.5BRCA1, CDK2, TP53
8
Show member pathways
9.4BRCA1, BRCA2, PLK1, TP53
99.3CCNB1, CDK2, PLK1, TP53
10
Show member pathways
9.2BRCA1, CDK2, PLK1, TP53
119.2AURKA, AURKB, CCNB1
129.2AURKA, AURKB, CCNB1
139.1BRCA1, CCNB1, CDK2, TP53
149.1BRCA1, CCNB1, CDK2, TP53
15
Show member pathways
9.1AURKA, CCNB1, CDK2, TP53
169.0BRCA1, BRCA2, CDK2, PLK1, TP53
17
Show member pathways
9.0CAT, CCNB1, CDK2, PLK1, SOD2
189.0CAT, CCNB1, CDK2, PLK1, SOD2
19
Show member pathways
8.9BRCA1, CCNB1, CDK2, TP53, TP73
20
Show member pathways
8.9BRCA1, CCNB1, CDK2, TP53, TP73
218.9AURKA, AURKB, BRCA1, TP53
22
Show member pathways
8.8BRCA1, CDK2, FBXO5, PLK1
23
Show member pathways
8.8AURKA, CCNB1, FBXO5, PLK1
248.8AURKB, BRCA2, CCNB1, CDK2, PLK1
25
Show member pathways
8.7BRCA1, BRCA2, CCNB1, CDK2, PARP1, TP53
26
Show member pathways
8.6AURKA, AURKB, BRCA1, PARP1, TP53
278.6AURKA, BRCA1, BRCA2, CDK2, PLK1, TP53
28
Show member pathways
8.4AURKA, CCNB1, CDK2, FBXO5, PLK1
29
Show member pathways
7.9AURKA, AURKB, BRCA1, CCNB1, CDK2, TP53
307.9AURKA, AURKB, CCNB1, CDK2, FBXO5, PLK1
31
Show member pathways
7.2AURKA, AURKB, BRCA1, BRCA2, CCNB1, CDK2
32
Show member pathways
7.1AURKA, AURKB, BRCA1, BRCA2, CCNB1, CDK2

GO Terms for genes affiliated with Tetraploidy

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Cellular components related to Tetraploidy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1spindle microtubuleGO:00058769.3AURKA, AURKB, PLK1
2spindleGO:00058198.9AURKA, AURKB, FBXO5

Biological processes related to Tetraploidy according to GeneCards Suite gene sharing:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1response to L-ascorbic acidGO:003359110.6CAT, SOD2
2negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:004573610.5LATS1, PLK1
3mitotic G1 DNA damage checkpointGO:003157110.5CDK2, TP73
4centrosome duplicationGO:005129810.3BRCA2, CDK2
5chordate embryonic developmentGO:004300910.3BRCA1, BRCA2
6centrosome organizationGO:005129710.3AURKA, PLK1
7negative regulation of neuron apoptotic processGO:004352410.2NGFR, SOD2, TP73
8intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:004277110.2BRCA2, TP53, TP73
9metaphase/anaphase transition of mitotic cell cycleGO:000709110.2FBXO5, PLK1
10response to cadmium ionGO:004668610.2CAT, CDK2, SOD2
11activation of APC-Cdc20 complex activityGO:000709210.2FBXO5, PLK1
12cellular response to UVGO:003464410.1AURKB, TP53, TP73
13meiotic nuclear divisionGO:000712610.1AURKA, CDK2
14G2 DNA damage checkpointGO:003157210.1BRCA1, PLK1
15spindle assembly involved in female meiosis IGO:000705710.1AURKA, FBXO5
16double-strand break repair via homologous recombinationGO:000072410.1BRCA1, BRCA2, PARP1
17response to gamma radiationGO:001033210.1BRCA2, SOD2, TP53, TP73
18spindle organizationGO:000705110.0AURKA, AURKB
19positive regulation of mitotic cell cycleGO:00459319.9BRCA2, CCNB1
20DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.9BRCA1, BRCA2, TP53, TP73
21intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.9BRCA1, BRCA2, SOD2, TP73
22G1/S transition of mitotic cell cycleGO:00000829.6CDK2, FBXO5, LATS1
23response to estradiolGO:00323559.5BRCA2, CAT, PTN
24oocyte maturationGO:00015569.4BRCA2, CCNB1, FBXO5
25regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleGO:00514399.4CCNB1, CDK2, FBXO5, PLK1
26cellular response to DNA damage stimulusGO:00069749.3BRCA1, BRCA2, PARP1, TP53, TP73
27G2/M transition of mitotic cell cycleGO:00000869.3AURKA, CDK2, PLK1
28mitotic nuclear divisionGO:00070679.1AURKA, AURKB, LATS1, PLK1
29negative regulation of apoptotic processGO:00430668.9AURKA, CAT, NGFR, PLK1, SOD2, TP53
30cell divisionGO:00513018.7AURKA, CCNB1, CDK2, FBXO5, LATS1
31anaphase-promoting complex-dependent catabolic processGO:00311458.4AURKA, AURKB, CCNB1, CDK2, FBXO5, PLK1
32protein phosphorylationGO:00064687.7AURKA, AURKB, CCNB1, CDK2, FLT3, LATS1

Sources for Tetraploidy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet