MCID: THL010
MIFTS: 33

Thalassemia Minor malady

Blood diseases category

Summaries for Thalassemia Minor

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63Wikipedia, 32MalaCards
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Wikipedia:63 Beta thalassemias (β thalassemias) are a group of inherited blood disorders caused by reduced or absent... more...

MalaCards: Thalassemia Minor, also known as beta thalassemia, heterozygous, is related to beta thalassemia and iron deficiency anemia. An important gene associated with Thalassemia Minor is HBB (hemoglobin, beta), and among its related pathways are African trypanosomiasis and Malaria. The compounds acetaminophen and dmsa have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and bone, and related mouse phenotypes are hematopoietic system and cardiovascular system.

Aliases & Classifications for Thalassemia Minor

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20GeneTests, 60UMLS
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Classifications:

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Anatomical: Blood diseases


Aliases & Descriptions:

thalassemia minor 20 60
beta thalassemia, heterozygous 60


Related Diseases for Thalassemia Minor

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Thalassemia Minor:



Diseases related to thalassemia minor

Clinical Features for Thalassemia Minor

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Drugs & Therapeutics for Thalassemia Minor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Thalassemia Minor

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20GeneTests
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Genetic tests related to Thalassemia Minor:

id Genetic test Affiliating Genes
1 Thalassemia Minor20

Anatomical Context for Thalassemia Minor

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32MalaCards
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MalaCards organs/tissues related to Thalassemia Minor:

32
Bone marrow, Bone

Animal Models for Thalassemia Minor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thalassemia Minor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.7HBB, HBA2, EPO, B2M, G6PD
2MP:00053857.5G6PD, B2M, PON1, EPO, HBB
3MP:00053767.1HBB, HBA2, EPO, PON1, B2M, G6PD

Publications for Thalassemia Minor

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Genetic Variations for Thalassemia Minor

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Expression for genes affiliated with Thalassemia Minor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thalassemia Minor

Search GEO for disease gene expression data for Thalassemia Minor.

Pathways for genes affiliated with Thalassemia Minor

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29KEGG, 53Reactome
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Pathways related to Thalassemia Minor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5HBB, HBA2
29.5HBB, HBA2
3
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8.7HBB, PON1, UGT1A1, G6PD

Compounds for genes affiliated with Thalassemia Minor

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Sources:
44Novoseek, 2BitterDB, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Thalassemia Minor according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1acetaminophen44 2 49 11 2414.5UGT1A1
2dmsa449.9G6PD, B2M
3cefazolin44 1110.8PON1, G6PD
4porphobilinogen44 11 2411.8B2M, HBB
5thiobarbituric acid449.8PON1, G6PD
6actb449.8B2M, G6PD
7hmba449.7HBB, HBA2
8iron dextran44 1110.6HBB, EPO
9glucose 6-phosphate44 2410.6G6PD, UGT1A1, HBB
10p-nitrophenol44 1110.6UGT1A1, PON1
11succinylacetone449.6EPO, HBB
12hemophan449.5EPO, B2M
13lamotrigine44 1110.5EPO, UGT1A1
14aluminium44 1110.5EPO, B2M
15phenol44 2410.5PON1, UGT1A1, G6PD
16an 69449.5EPO, B2M
17polyacrylonitrile449.5B2M, EPO
18zinc protoporphyrin449.5G6PD, EPO
19fumarate44 1110.4G6PD, EPO
20valine449.4HBB, B2M, HBA2
21uric acid44 2410.4PON1, B2M, G6PD
22vitamin-e449.4B2M, PON1, G6PD
23glyceraldehyde 3-phosphate449.4G6PD, HBB, B2M
24benzidine449.3UGT1A1, HBB, EPO
25cuprophan449.3EPO, B2M
26cellulose acetate449.3G6PD, B2M, HBA2
27polysulfone449.3EPO, B2M
28tamoxifen44 49 28 1112.2HBB, UGT1A1, G6PD
29azathioprine44 49 2 1112.2EPO, G6PD, HBB
30gemfibrozil44 28 1111.2G6PD, PON1
31aspartate449.2B2M, HBB, UGT1A1, G6PD
32malondialdehyde449.1G6PD, PON1, EPO
33thyroxine44 2410.0B2M, UGT1A1, G6PD, PON1
34glutamine449.0G6PD, PON1, HBB, B2M
35leucine448.9UGT1A1, PON1, HBA2, HBB
36methionine448.9PON1, HBB, HBA2
37ascorbic acid44 249.8G6PD, EPO, PON1
38hydroxyurea44 49 1110.7HBB, UGT1A1, HBA2, EPO
39lactate448.7B2M, G6PD, HBB, EPO
4023-diphosphoglycerate448.7G6PD, EPO, HBA2, HBB
41cisplatin44 49 59 1111.6EPO, B2M, UGT1A1, G6PD
42vitamin b12448.6B2M, EPO, PON1, G6PD
43folate448.6G6PD, EPO, B2M, PON1
44butyrate448.6B2M, HBA2, HBB, EPO
45iron44 249.5HBA2, HBB, B2M, EPO
46creatinine448.5B2M, EPO, G6PD, PON1
47alanine448.4HBB, UGT1A1, HBA2, PON1, B2M
48oxygen44 249.2HBA2, G6PD, EPO, HBB
49testosterone44 59 11 2411.2PON1, EPO, B2M, UGT1A1, G6PD
50thymidine44 249.2HBA2, HBB, EPO, B2M, UGT1A1

GO Terms for genes affiliated with Thalassemia Minor

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16Gene Ontology
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Cellular components related to Thalassemia Minor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin-hemoglobin complexGO:0318389.5HBB, HBA2
2hemoglobin complexGO:0058339.4HBB, HBA2
3endocytic vesicle lumenGO:0716829.2HBA2, HBB
4extracellular regionGO:0055767.6HBB, HBA2, EPO, PON1, B2M

Biological processes related to Thalassemia Minor according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1oxygen transportGO:0156719.6HBB, HBA2
2hydrogen peroxide catabolic processGO:0427449.5HBA2, HBB
3positive regulation of cell deathGO:0109429.5HBA2, HBB
4protein heterooligomerizationGO:0512919.5HBB, HBA2
5bicarbonate transportGO:0157019.4HBB, HBA2
6erythrocyte maturationGO:0432499.3EPO, G6PD
7response to hydrogen peroxideGO:0425429.2HBB, HBA2

Molecular functions related to Thalassemia Minor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin bindingGO:0317209.5HBB, HBA2
2oxygen bindingGO:0198259.5HBB, HBA2
3oxygen transporter activityGO:0053449.4HBB, HBA2
4peroxidase activityGO:0046019.2HBB, HBA2

Products for genes affiliated with Thalassemia Minor

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  • Antibodies
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Sources for Thalassemia Minor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet