MCID: THL010
MIFTS: 40

Thalassemia Minor malady

Blood category

Summaries for Thalassemia Minor

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64Wikipedia, 33MalaCards
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Wikipedia:64 Beta-thalassemias (β-thalassemias) are a group of inherited blood disorders caused by reduced or absent... more...

MalaCards: Thalassemia Minor, also known as beta thalassemia, heterozygous, is related to thalassemia and beta thalassemia. An important gene associated with Thalassemia Minor is HBB (hemoglobin, beta), and among its related pathways are African trypanosomiasis and Malaria. The compounds acetaminophen and dmsa have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and bone marrow, and related mouse phenotypes are hematopoietic system and cardiovascular system.

Aliases & Classifications for Thalassemia Minor

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20GeneTests, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

thalassemia minor 20 61
beta thalassemia, heterozygous 61


Related Diseases for Thalassemia Minor

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Thalassemia Minor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1thalassemia31.6UGT1A1, EPO, G6PD, HBB, HBA2
2beta thalassemia31.4HBA2, HBB
3iron deficiency anemia30.9EPO, G6PD
4deficiency anemia30.8B2M, G6PD, EPO, HBA2, HBB
5alpha thalassemia30.5G6PD, HBB, UGT1A1, HBA2
6hemochromatosis30.4HBB, B2M
7pyruvate kinase deficiency30.1G6PD
8hepatitis c30.1PON1
9viral hepatitis30.1G6PD
10t cell deficiency10.4
11arthritis10.4
12b cell deficiency10.4
13hemoglobin c - beta-thalassemia10.4
14bipolar disorder10.3
15hemoglobin s beta-thalassemia10.2
16nephritis10.2
17hemoglobin e - beta-thalassemia10.2
18hemoglobin d disease10.1
19hemoglobin c disease10.1
20favism10.1
21thyroid lymphoma10.1
22hemosiderosis10.1
23hypochromic microcytic anemia10.1
24diabetes insipidus10.1
25retinitis pigmentosa10.1
26coats disease10.1
27hypochromic anemia10.1
28bronchitis10.1
29hepatitis d10.1
30wilson disease10.1
31hypersplenism10.1
32nephrocalcinosis10.1
33megaloblastic anemia10.1
34nephrogenic diabetes insipidus10.1
35cleidocranial dysplasia10.1
36hepatitis a10.1
37osteoporosis10.1
38epidermolysis bullosa, pretibial10.1
39lupus nephritis10.1
40hemoglobin so10.1
41short stature10.1
42thalassemia, hispanic gamma-delta-beta10.1
43delta-beta thalassemia10.1
44thalassemia, delta-10.1
45insulin resistance10.1
46fibromyalgia10.1
47nephrogenic diabetes insipidus - intracranial calcification10.1
48cholelithiasis10.0UGT1A1
49thromboembolism10.0G6PD
50tuberculosis10.0HBB

Graphical network of the top 20 diseases related to Thalassemia Minor:



Diseases related to thalassemia minor

Clinical Features for Thalassemia Minor

Drugs & Therapeutics for Thalassemia Minor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Thalassemia Minor

Drug clinical trials:

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Search NIH Clinical Center for Thalassemia Minor

Search CenterWatch for Thalassemia Minor

Genetic Tests for Thalassemia Minor

Sources:
20GeneTests
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Genetic tests related to Thalassemia Minor:

id Genetic test Affiliating Genes
1 Thalassemia Minor20

Anatomical Context for Thalassemia Minor

Sources:
33MalaCards
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MalaCards organs/tissues related to Thalassemia Minor:

33
Liver, Kidney, Bone marrow, Whole blood, Thyroid, B cells, Endothelial, Fetal liver, Fetal thyroid

Animal Models for Thalassemia Minor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Thalassemia Minor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.7EPO, HBA2, G6PD, HBB, B2M
2MP:00053857.5HBB, G6PD, B2M, PON1, EPO
3MP:00053767.1G6PD, B2M, PON1, EPO, HBA2, HBB

Publications for Thalassemia Minor

Sources:
51PubMed
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Articles related to Thalassemia Minor:

(show top 50)    (show all 146)
idTitleAuthorsYear
1
Use of serum iron status and hemoglobin A2 levels for discrimination between iron deficiency and thalassemia minor. (23327659)
2013
2
Combined iron deficiency and thalassemia minor. (23355213)
2013
3
Determining and surveying the role of carnitine and folic acid to decrease fatigue in I^-thalassemia minor subjects. (23458634)
2013
4
Coronary Microvascular function, Peripheral Endothelial Function and Carotid IMT in beta-thalassemia minor. (23683324)
2013
5
Pseudothrombocytosis due to microerythrocytosis: a case of beta thalassemia minor complicated with iron deficiency anemia. (23485560)
2013
6
Comparison between I^-thalassemia minor and normal individuals using the Wechsler Adult Intelligence Scale. (23806085)
2013
7
Prevalance of iron deficiency in thalassemia minor: a study from tertiary hospital. (23449336)
2012
8
Proposal of a score combining red blood cell indices for early differentiation of beta-thalassemia minor from iron deficiency anemia. (21418745)
2011
9
Identification of a new mutation on the beta-globin gene: codons 8/9 (+AGAA); GAG.AAG.TCT(Glu-Lys-Ser)>GAG. AAAGAAG, in a patient from the north of France with a phenotype of beta-thalassemia minor. (20642337)
2010
10
A new index for discrimination between iron deficiency anemia and beta-thalassemia minor: results in 284 patients. (19579993)
2009
11
Prevalence of hepatosplenomegaly in beta thalassemia minor subjects in Iran. (18029131)
2009
12
Treatment with hydroxyurea in a patient compound heterozygote for a high oxygen affinity hemoglobin and beta-thalassemia minor. (19787797)
2009
13
{beta}-thalassemia major evolution from {beta}-thalassemia minor is associated with paternal uniparental isodisomy of chromosome 11p15. (18413893)
2008
14
Effect of epoetin zeta for correction of renal anemia in hemodialysis patients with thalassemia minor. (19043680)
2008
15
Long-term L-carnitine administration reduces erythropoietin resistance in chronic hemodialysis patients with thalassemia minor. (21901057)
2007
16
Evaluation of reticulocyte parameters in iron deficiency, vitamin B(12) deficiency and beta-thalassemia minor patients. (17824912)
2007
17
Validity assessment of nine discriminant functions used for the differentiation between iron deficiency anemia and thalassemia minor. (17166936)
2007
18
Measurement of reticulocyte and red blood cell indices in patients with iron deficiency anemia and beta-thalassemia minor. (15843216)
2005
19
Acute subarachnoid hemorrhage associated with platelet storage pool disease and the hemoglobinopathy caused by beta-thalassemia minor. (17903974)
2004
20
Efficacy of erythropoietin on dialysis in patients with beta thalassemia minor. (15359104)
2004
21
Effects of beta thalassemia minor on results of six glycated hemoglobin methods. (15530468)
2004
22
Thalassemia minor, the Gilbert mutation, and the risk of gallstones. (14555305)
2003
23
Relationship between resistance to erythropoietin and high anomalous hemoglobin levels in hemodialysis patients with beta-thalassemia minor. (14586179)
2003
24
Heterozygosity for the H63D mutation in the hereditary hemochromatosis (HFE) gene may lead into severe iron overload in beta-thalassemia minor: observations in a thalassemic kindred. (11421105)
2001
25
Superiority of neural networks over discriminant functions for thalassemia minor screening of red blood cell microcytosis. (7726727)
1995
26
Prevalence of thalassemia minor trait in Pakistani population presented at Akuh for complete blood count estimation (CBC). (8264087)
1993
27
A family case of beta-thalassemia minor and hemoglobin Queens: alpha 34 (B15) Leu-Arg. (1299245)
1992
28
Whole blood viscosity in beta thalassemia minor. (1503390)
1992
29
Thalassemia minor: a risk factor for osteoporosis? (1537008)
1992
30
Alpha-thalassemia minor and neonatal hyperbilirubinemia. (1977848)
1990
31
Antenatal screening for thalassemia minor. (3357669)
1988
32
Masked phenytoin-induced megaloblastic anemia in beta-thalassemia minor. (3113162)
1987
33
Bipolar affective disorder and thalassemia minor. (3717440)
1986
34
Arthritis in thalassemia minor. (6477662)
1984
35
Chronic viral hepatitis in thalassemic liver disease. A long-term study in patients with acute hepatitis with nontransfusion-dependent thalassemia minor. (6402856)
1983
36
Coincidental nontransfusional iron overload and thalassemia minor: association with HLA-linked hemochromatosis. (7272512)
1981
37
Erythrocyte phospholipid fatty acid fluctuations in patients with beta-thalassemia minor. (7214695)
1980
38
Independent segregation of HLA--A, --B and --C antigens from thalassemia minor. (494226)
1979
39
Quantitative anisocytosis as a discriminant between iron deficiency and thalassemia minor. (760854)
1979
40
Thalassemia minor and aseptic necrosis, a coincidence? (637896)
1978
41
Thalassemia minor. Cause of complications in pregnant Black and Hispanic women. (279806)
1978
42
alpha Thalassemia minor trait accompanied by clinical oral signs. Report of a case. (266681)
1977
43
Intraerythrocytic adaptation (2,3 DPG,P50) in thalassemia minor. (836953)
1977
44
Routine erythrocyte measurements in diagnosis of iron-deficiency anemia and thalassemia minor. (983994)
1976
45
Maternal anemia and fetal outcome in pregnancies complicated by thalassemia minor and "stomatocytosis". (4707531)
1973
46
Histopathologic studies in beta-thalassemia minor and intermedia. (5260138)
1969
47
Hemoglobin A'2 abnormality associated with thalassemia minor in a Greek woman. Study of a family. (5956225)
1966
48
THE ASSOCIATION OF HEMOCHROMATOSIS WITH THALASSEMIA MINOR. (14305959)
1965
49
TRUE RED BLOOD CELL SURVIVAL WITH RADIOCHROMIUM BY CORRECTING FOR PERCENTAGE OF ACTIVITY NOT BOUND TO HEMOGLOBIN. DEMONSTRATION OF TWO ERYTHROCYTE POPULATIONS IN NORMALS AND IN THALASSEMIA MINOR. ERYTHROPOIESIS AND THE THALASSEMIA TRAIT. (14219437)
1964
50
A statistical study of the hematologic variables in subjects with thalassemia minor. (18123114)
1948

Genetic Variations for Thalassemia Minor

Expression for genes affiliated with Thalassemia Minor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thalassemia Minor

Search GEO for disease gene expression data for Thalassemia Minor.

Pathways for genes affiliated with Thalassemia Minor

Sources:
30KEGG, 54Reactome
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Pathways related to Thalassemia Minor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5HBB, HBA2
29.5HBB, HBA2
3
Hide members
8.7HBB, PON1, UGT1A1, G6PD

Compounds for genes affiliated with Thalassemia Minor

Sources:
45Novoseek, 2BitterDB, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Thalassemia Minor according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1acetaminophen45 2 50 11 2414.5UGT1A1
2dmsa459.9G6PD, B2M
3cefazolin45 1110.8G6PD, PON1
4porphobilinogen45 11 2411.8HBB, B2M
5actb459.8G6PD, B2M
6thiobarbituric acid459.8G6PD, PON1
7hmba459.7HBB, HBA2
8iron dextran45 1110.6EPO, HBB
9glucose 6-phosphate45 2410.6G6PD, UGT1A1, HBB
10p-nitrophenol45 1110.6UGT1A1, PON1
11succinylacetone459.6HBB, EPO
12hemophan459.5EPO, B2M
13lamotrigine45 1110.5UGT1A1, EPO
14aluminium45 1110.5B2M, EPO
15phenol45 2410.5PON1, UGT1A1, G6PD
16an 69459.5B2M, EPO
17polyacrylonitrile459.5B2M, EPO
18zinc protoporphyrin459.5EPO, G6PD
19fumarate45 1110.4EPO, G6PD
20valine459.4HBB, HBA2, B2M
21uric acid45 2410.4G6PD, B2M, PON1
22vitamin-e459.4G6PD, B2M, PON1
23glyceraldehyde 3-phosphate459.4G6PD, B2M, HBB
24benzidine459.3HBB, EPO, UGT1A1
25cuprophan459.3EPO, B2M
26cellulose acetate459.3G6PD, B2M, HBA2
27polysulfone459.3B2M, EPO
28tamoxifen45 50 29 1112.2HBB, UGT1A1, G6PD
29azathioprine45 50 2 1112.2G6PD, EPO, HBB
30gemfibrozil45 29 1111.2PON1, G6PD
31aspartate459.2HBB, B2M, UGT1A1, G6PD
32malondialdehyde459.1G6PD, PON1, EPO
33thyroxine45 2410.0G6PD, UGT1A1, B2M, PON1
34glutamine459.0G6PD, B2M, PON1, HBB
35leucine458.9UGT1A1, PON1, HBA2, HBB
36methionine458.9PON1, HBA2, HBB
37ascorbic acid45 249.8EPO, PON1, G6PD
38hydroxyurea45 50 1110.7UGT1A1, EPO, HBA2, HBB
39lactate458.7HBB, EPO, B2M, G6PD
4023-diphosphoglycerate458.7HBB, HBA2, EPO, G6PD
41cisplatin45 50 60 1111.6EPO, B2M, UGT1A1, G6PD
42vitamin b12458.6G6PD, B2M, PON1, EPO
43folate458.6G6PD, B2M, PON1, EPO
44butyrate458.6B2M, EPO, HBA2, HBB
45iron45 249.5HBB, HBA2, EPO, B2M
46creatinine458.5EPO, PON1, B2M, G6PD
47alanine458.4HBB, HBA2, PON1, B2M, UGT1A1
48oxygen45 249.2HBB, HBA2, EPO, G6PD
49testosterone45 60 11 2411.2G6PD, UGT1A1, B2M, PON1, EPO
50thymidine45 249.2UGT1A1, B2M, EPO, HBA2, HBB

GO Terms for genes affiliated with Thalassemia Minor

Sources:
16Gene Ontology
See all sources

Cellular components related to Thalassemia Minor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin-hemoglobin complexGO:0318389.5HBB, HBA2
2hemoglobin complexGO:0058339.4HBB, HBA2
3endocytic vesicle lumenGO:0716829.2HBA2, HBB
4extracellular regionGO:0055767.6HBB, HBA2, EPO, PON1, B2M

Biological processes related to Thalassemia Minor according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1oxygen transportGO:0156719.6HBB, HBA2
2hydrogen peroxide catabolic processGO:0427449.5HBA2, HBB
3positive regulation of cell deathGO:0109429.5HBA2, HBB
4protein heterooligomerizationGO:0512919.5HBB, HBA2
5bicarbonate transportGO:0157019.4HBB, HBA2
6erythrocyte maturationGO:0432499.3EPO, G6PD
7response to hydrogen peroxideGO:0425429.2HBB, HBA2

Molecular functions related to Thalassemia Minor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin bindingGO:0317209.5HBB, HBA2
2oxygen bindingGO:0198259.5HBB, HBA2
3oxygen transporter activityGO:0053449.4HBB, HBA2
4peroxidase activityGO:0046019.2HBB, HBA2

Products for genes affiliated with Thalassemia Minor

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Sources for Thalassemia Minor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet