Thoracic Aortic Aneurysm malady

CDC: An aortic aneurysm (AA) is a ballooning or dilatation of the aorta, the large artery that carries blood from the heart through the chest and abdomen. AAs are classified according to their location; in the chest, it is called a thoracic AA, in the abdomen an abdominal AA (AAA), and across both areas a thoracoabdominal AA.²

MalaCards: Thoracic Aortic Aneurysm, also known as thoracic aortic aneurysm without mention of rupture (disorder), is related to familial thoracic aortic aneurysm and dissection and thoracic aortic aneurysms and aortic dissections. An important gene associated with Thoracic Aortic Aneurysm is ACTA2 (actin, alpha 2, smooth muscle, aorta), and among its related pathways are Downregulation of TGF-beta receptor signaling and TGF-beta/Smad Signaling. The drug trimethaphan camsylate and the compounds serine and bleomycin have been mentioned in the context of this disorder. Affiliated tissues include heart, smooth muscle and t cells, and related mouse phenotypes are growth/size and homeostasis/metabolism.

Wikipedia: A thoracic aortic aneurysm is an aortic aneurysm that presents primarily in the thorax.⁴⁴ more...

Aliases & Descriptions:

thoracic aortic aneurysm 6 8 thoracic aortic aneurysm without mention of rupture (disorder) 6 thoracic aortic aneurysm without mention of rupture 6 thoracic aortic aneurysm without rupture 6

aortic aneurysm, thoracic 43 aortic aneurysm thoracic 32 aortic aneurysm 43

Diseases related to thoracic aortic aneurysm by text searches and GeneDecks gene sharing:

(show top 50)    (show all 316)

id	Related Disease	Score	Top Affiliating Genes
1	familial thoracic aortic aneurysm and dissection	35.8	FBN1, SMAD3, COL3A1, ACTA2, TGFBR1, TGFBR2
2	thoracic aortic aneurysms and aortic dissections	35.2	FBN1, ACTA2, TGFBR1, TGFBR2, MYH11
3	ruptured thoracic aortic aneurysm	34.6	MPL, ACTA1
4	aneurysm disease	33.1	MMP9, FBN1, ELN
5	loeys-dietz syndrome	32.7	FBN1, SMAD3, COL3A1, ACTA2, TGFBR1, TGFBR2
6	aortic disease	31.1	FBN1, ELN
7	marfan syndrome	30.6	BMP6, MMP2, FBN1, COL3A1, ELN, TGFBR1
8	patent ductus arteriosus	30.6	MMP9, TNF, COL3A1, TGFBR1, TGFBR2, MYH11
9	cutis laxa	30.1	BMP6, FBN1, ELN
10	ehlers-danlos syndrome type iv	29.8	COL3A1, ELN
11	abdominal aortic aneurysm	29.3	MMP2, MMP8, MMP9, FBN1, ELN
12	ehlers-danlos syndrome	29.2	FBN1, COL3A1, ELN, THBS2
13	chronic obstructive pulmonary disease	28.8	MMP8, MMP9, TNF, ELN, TGFBR2
14	aortic aneurysm	28.6	BMP6, MMP2, MMP8, MMP9, MFGE8, FBN1
15	hernia	27.8	MMP2, MMP9, FBN1, TNF, COL3A1, ELN
16	ischemia	27.8	MMP2, MMP9, MFGE8, GPX1, HSPA8, HMGB1
17	antiphospholipid syndrome	27.3	MMP2, MMP9, TNF, ELN
18	intracranial aneurysm	27.2	MMP2, MMP9, CYBA, COL3A1, ELN, TGFBR1
19	homocysteine	27.2	MMP2, MMP9, FBN1, GPX1, TNF, NOTCH1
20	polycystic kidney disease	26.9	MMP2, MMP9, FBN1, TNF, AGT
21	pneumonia	26.2	BMP6, MMP2, MMP8, MMP9, GPX1, HSPA8
22	pulmonary disease	25.6	BMP6, MMP2, MMP8, MMP9, GPX1, HMGB1
23	inflammatory bowel disease	25.2	BMP6, MMP2, MMP9, HSPA8, TNF, SMAD3
24	atherosclerosis	25.1	BMP6, MMP2, MMP8, MMP9, MFGE8, FBN1
25	obesity	24.9	BMP6, MMP2, MMP8, MMP9, TNF, CYBA
26	hypertension	23.7	BMP6, MMP2, MMP9, FBN1, GPX1, HSPA8
27	hypoxia	22.9	BMP6, MMP2, MMP9, GPX1, HSPA8, HMGB1
28	marfan-like connective tissue disorder	13.7	TGFBR1, TGFBR2
29	left ventricular outflow tract obstruction (lvoto)	13.3	FBN1, NOTCH1, ELN
30	pneumothorax	13.3	FBN1, COL3A1, ELN
31	supravalvular aortic stenosis	13.2	FBN1, ELN
32	cecum cancer	13.1	BMP6, TGFBR2
33	neurocirculatory asthenia	13.0	FBN1, COL3A1, ELN, AGT
34	staphylococcal toxic shock syndrome	13.0	HMGB1, TNF
35	hereditary hemorrhagic telangiectasia	13.0	BMP6, TGFBR1
36	granuloma annulare	12.9	MMP2, TNF
37	renovascular hypertension	12.9	FBN1, TNF, AGT
38	lichen sclerosus	12.9	FBN1, TNF, ELN
39	mayer-rokitansky-kuster-hauser syndrome	12.9	FBN1, CYBA, COL3A1, ELN, TGFBR1
40	diabetic foot ulcers	12.9	MMP9, TGFBR1, TGFBR2
41	telangiectasis	12.9	BMP6, FBN1, ELN, TGFBR1
42	ankylosing spondylitis	12.8	FBN1, HSPA8, TNF
43	gingival overgrowth	12.8	MMP8, TNF, THBS2, TGFBR2
44	ureteral obstruction	12.8	BMP6, SMAD3, ADAMTS1
45	craniosynostosis	12.8	BMP6, FBN1, SMAD3, TGFBR1, TGFBR2
46	sorsby fundus dystrophy	12.7	MMP9, ELN
47	systemic scleroderma	12.7	BMP6, FBN1, SMAD3, COL3A1, TGFBR1
48	immunodysregulation	12.7	BMP6, HMGB1
49	oral submucous fibrosis	12.7	MMP2, MMP8, TNF
50	systolic heart failure	12.6	MMP2, TNF, AGT

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 trimethaphan camsylate

MalaCards organs/tissues related to thoracic aortic aneurysm:

²²

MGI Mouse Phenotypes related to thoracic aortic aneurysm:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	INF	MYH11, TGFBR2, TGFBR1, AGT, , COL3A1
2	homeostasis/metabolism phenotype	MP:0005376	INF	, ELN, AGT, THBS2, TGFBR1, TGFBR2
3	respiratory system phenotype	MP:0005388	9.3	MYH11, THBS2, ELN, COL3A1, CYBA, FBN1
4	integument phenotype	MP:0010771	9.3	MYH11, THBS2, COL3A1, NOTCH1, FBN1, MFGE8
5	renal/urinary system phenotype	MP:0005367	9.0	MYH11, ADAMTS1, AGT, NOTCH1, FBN1, MFGE8
6	digestive/alimentary phenotype	MP:0005381	7.7	MYH11, TGFBR2, COL3A1, NOTCH1, SMAD3, TNF
7	tumorigenesis	MP:0002006	7.3	NOTCH1, THBS2, TGFBR1, TGFBR2, SMAD3, TNF
8	cardiovascular system phenotype	MP:0005385	6.1	ELN, AGT, THBS2, TGFBR1, TGFBR2, MYH11
9	muscle phenotype	MP:0005369	INF	MMP2, MYH11, TGFBR2, TGFBR1, THBS2, AGT
10	immune system phenotype	MP:0005387	INF	CYBA, TNF, GPX1, FBN1, MFGE8, MMP8
11	vision/eye phenotype	MP:0005391	INF	TGFBR2, ACTA2, , NOTCH1, SMAD3, TNF
12	hematopoietic system phenotype	MP:0005397	INF	THBS2, NOTCH1, FBN1, MFGE8,
13	cellular phenotype	MP:0005384	INF	SMAD3, NOTCH1, THBS2, TGFBR1, TGFBR2, TNF
14	behavior/neurological phenotype	MP:0005386	INF	SIGMAR1, TGFBR2, THBS2, AGT, , SMAD3
15	mortality/aging	MP:0010768	INF	MYH11, ADAMTS1, TGFBR2, TGFBR1, THBS2, AGT
16	skeleton phenotype	MP:0005390	INF	TGFBR2, TGFBR1, , NOTCH1, SMAD3, MMP9
17	adipose tissue phenotype	MP:0005375	INF	TGFBR2, AGT, , TNF, FBN1, ADAMTS1

Articles related to thoracic aortic aneurysm:

(show all 38)

id	Title	Authors	Year	Affiliating Genes
1	Three novel mutations in the ACTA2 gene in German pat ients with thoracic aortic aneurysms and dissections. (21248741)	Hoffjan S.... Scheffold T.	2011	ACTA2
2	Exome sequencing identifies SMAD3 mutations as a caus e of familial thoracic aortic aneurysm and dissection with intracranial and oth er arterial aneurysms. (21778426)	Regalado E.S.... Milewicz D.M.	2011	SMAD3
3	Allele-specific effects of thoracic aortic aneurysm a nd dissection alpha-smooth muscle actin mutations on actin function. (21288906)	Bergeron S.E.... Bartlett H.L.	2011	ACTA2
4	Impact of serum high-mobility group box 1 protein ele vation on oxygenation impairment after thoracic aortic aneurysm repair. (21052685)	Kohno T.... Ogawa S.	2011	HMGB1
5	Autosomal dominant inheritance of a predisposition to thoracic aortic aneurysms and dissections and intracranial saccular aneurysms. (21815248)	Regalado E.... Milewicz D.M.	2011	TGFBR2, TGFBR1, ACTA2
6	Genome-wide association study identifies a susceptibi lity locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 a t 15q21.1. (21909107)	LeMaire S.A.... Milewicz D.M.	2011	FBN1
7	TGFBR2 mutations alter smooth muscle cell phenotype a nd predispose to thoracic aortic aneurysms and dissections. (20628007)	Inamoto S.... Milewicz D.M.	2010	TGFBR2
8	Clinical, pathological, and genetic analysis of a Kor ean family with thoracic aortic aneurysms and dissections carrying a novel Asp2 6Tyr mutation. (20689142)	Yoo E.H.... Kim D.K.	2010	ACTA2
9	Mutation of ACTA2 gene as an important cause of familial and nonfamilial nonsyndromatic thoracic aortic aneurysm and/or dissection (TAAD). (19639654)	Morisaki H.... Morisaki T.	2009	TGFBR2, TGFBR1, COL3A1
10	Ascending thoracic aortic aneurysms are associated with compositional remodeling and vessel stiffening but not weakening in age-matched subjects. (19154911)	Iliopoulos D.C.... Sokolis D.P.	2009	ELN
11	Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis. (18765947)	Jones J.A.... Ikonomidis J.S.	2009	BMP6
12	Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutations. (19542084)	Tran-Fadulu V.... Milewicz D.M.	2009	TGFBR2, TGFBR1
13	Thoracic aortic aneurysm: reading the enemy's playbook. (18439439)	Elefteriades J.A.	2008	MMP8
14	Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in marfan syndrome through the inhibition of matrix metalloproteinase-2 and -9. (18388324)	Chung A.W.... van Breemen C.	2008	MMP2
15	Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction. (18544034)	Milewicz D.M.... Pannu H.	2008	TGFBR2, FBN1, ACTA2
16	Assessment of Genetic Risk Factors for Thoracic Aortic Aneurysm in Hypertensive Patients. (18600213)	Kato K.... Yamada Y.	2008	HSPA8, TNF, GPX1
17	Role of aggregated medin in the pathogenesis of thoracic aortic aneurysm and dissection. (17906662)	Peng S.... Westermark P.	2007	MFGE8
18	Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms. (17662764)	McKellar S.H.... Sundt T.M.	2007	NOTCH1
19	Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections. (17994018)	Guo D.-C.... Milewicz D.M.	2007	MYH11
20	Matrix metalloproteinase and tissue inhibitor expression in atherosclerotic and nonatherosclerotic thoracic aortic aneurysms. (17198804)	Schmoker J.D.... Howard A.	2007	MMP2
21	A single nucleotide polymorphism in the matrix metalloproteinase 9 gene (-8202A/G) is associated with thoracic aortic aneurysms and thoracic aortic dissection. (16678588)	Chen L.... LeMaire S.A.	2006	MMP9
22	Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. (16444274)	Zhu L.... Jeunemaitre X.	2006	MYH11
23	Familial thoracic aortic aneurysms and dissections: three families with early-onset ascending and descending aortic dissections in women. (16646045)	Tran-Fadulu V.... Milewicz D.M.	2006	TGFBR2, FBN1
24	A biologic basis for asymmetric growth in descending thoracic aortic aneurysms: a role for matrix metalloproteinase 9 and 2. (16476613)	Sinha I.... Upchurch G.R.	2006	MMP2, MMP9
25	Genetic basis of thoracic aortic aneurysms and dissections: potential relevance to abdominal aortic aneurysms. (17182941)	Pannu H.... Milewicz D.M.	2006	TGFBR2
26	Altered patterns of gene expression specific to thoracic aortic aneurysms: microarray analysis of surgically resected specimens. (15876810)	Taketani T.... Takamoto S.	2005	ADAMTS1, CASP4
27	Genetic basis of thoracic aortic aneurysms and aortic dissections. (16273536)	Pannu H.... Milewicz D.M.	2005	TGFBR2
28	Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections. (16027248)	Pannu H.... Milewicz D.M.	2005	TGFBR2
29	Matrix metalloproteinase activity in thoracic aortic aneurysms associated with bicuspid and tricuspid aortic valves. (15001896)	Boyum J.... Howard A.B.	2004	MMP2, MMP9
30	Familial thoracic aortic aneurysm/dissection with patent ductus arteriosus: genetic arguments for a particular pathophysiological entity. (14722581)	Khau Van Kien P.... Jeunemaitre X.	2004	COL3A1
31	Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections. (15561045)	Koullias G.J.... Elefteriades J.A.	2004	MMP9
32	Oxidative stress in the pathogenesis of thoracic aortic aneurysm: protective role of statin and angiotensin II type 1 receptor blocker. (14553839)	Ejiri J.... Yokoyama M.	2003	CYBA
33	Mapping a locus for familial thoracic aortic aneurysms and dissections (TAAD2) to 3p24-25. (12821554)	Hasham S.N.... Milewicz D.M.	2003	TGFBR2
34	Familial thoracic aortic aneurysms and dissections: genetic heterogeneity with a major locus mapping to 5q13-14. (11369686)	Guo D.... Milewicz D.M.	2001	AAT2
35	Thoracic aortic aneurysm. New evidence for fibrillin -1 involvement (10670197)	Pepe G.... Gensini G.F.	1999	FBN1
36	Immunohistochemistry of matrix metalloproteinases and their inhibitors in thoracic aortic aneurysms and aortic valves of patients with Marfan's syndrome. (9852923)	Segura A.M.... Ferrans V.J.	1998	ELN
37	Reduced penetrance and variable expressivity of famil ial thoracic aortic aneurysms/dissections. (9723636)	Milewicz D.M.... Patel V.	1998	FBN1
38	Fibrillin-1 (FBN1) mutations in patients with thoracic aortic aneurysms. (8941093)	Milewicz D.M.... Biddinger A.	1996	FBN1

Genes related to thoracic aortic aneurysm according to GeneCards:

(show all 25)

id	Symbol	Description	Score	GeneCards Section Context
1	ACTA2	actin, alpha 2, smooth muscle, aorta	11.0	Publications
2	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	11.0	Publications
3	TGFBR1	transforming growth factor, beta receptor 1	11.0	Publications
4	MYH11	myosin, heavy chain 11, smooth muscle	11.0	Publications
5	FBN1	fibrillin 1	11.0	Publications
6	AAT2	Aortic aneurysm, familial thoracic 2	11.0	Publications
7	COL3A1	collagen, type III, alpha 1	11.0	Publications
8	SMAD3	SMAD family member 3	11.0	Publications
9	SIGMAR1	sigma non-opioid intracellular receptor 1	11.0	Publications
10	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	11.0	Publications
11	MFGE8	milk fat globule-EGF factor 8 protein	11.0	Publications
12	THBS2	thrombospondin 2	11.0	Publications
13	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
14	GPX1	glutathione peroxidase 1	11.0	Publications
15	CASP4	caspase 4, apoptosis-related cysteine peptidase	11.0	Publications
16	CYBA	cytochrome b-245, alpha polypeptide	11.0	Publications
17	NOTCH1	notch 1	11.0	Publications
18	HMGB1	high mobility group box 1	11.0	Publications
19	ELN	elastin	11.0	Publications
20	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
21	HSPA8	heat shock 70kDa protein 8	11.0	Publications
22	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
23	BMP6	bone morphogenetic protein 6	11.0	Publications
24	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
25	TNF	tumor necrosis factor	11.0	Publications

Pathways related to thoracic aortic aneurysm according to GeneDecks:

(show all 38)

id	Pathway	Score	Top Affiliating Genes
1	Downregulation of TGF-beta receptor signaling38	10.3	SMAD3, TGFBR1, TGFBR2
2	TGF-beta/Smad Signaling3	10.2	SMAD3, TGFBR1, TGFBR2
3	Cytokine production by Th17 cells in CF (Mouse model)41	10.0	SMAD3, TGFBR1, TGFBR2
4	Th17 Differentiation37	9.9	TGFBR2, TGFBR1, SMAD3
5	Development_Glucocorticoid receptor signaling41	9.9	TGFBR1, SMAD3, HSPA8
6	Development Glucocorticoid receptor signaling10	9.9	TGFBR1, SMAD3, HSPA8
7	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.8	TGFBR1, SMAD3, TNF
8	Transcription_Androgen Receptor nuclear signaling41	9.8	TGFBR2, TGFBR1, SMAD3, MMP2
9	Transcription Androgen Receptor nuclear signaling10	9.7	TGFBR2, TGFBR1, SMAD3, MMP2
10	Chagas disease (American trypanosomiasis)20	9.7	TNF, SMAD3, TGFBR1, TGFBR2
11	Osteoclast differentiation20	9.6	TGFBR2, TGFBR1, CYBA, TNF
12	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.5	TNF, SMAD3, TGFBR1
13	Activation of Matrix Metalloproteinases38	9.2	MMP2, MMP8, MMP9
14	Molecular Mechanisms of Cancer36	9.2	TGFBR2, TGFBR1, COL3A1, NOTCH1, FBN1, BMP6
15	Inhibition of Matrix Metalloproteinases36	9.0	MMP2, MMP8, MMP9, THBS2
16	Inhibition of Angiogenesis by TSP136	9.0	TGFBR2, TGFBR1, ELN, COL3A1, FBN1, MMP9
17	Angiogenesis3	9.0	TGFBR1, NOTCH1, MMP9, MMP2
18	TGF-beta signaling pathway20	9.0	TGFBR2, TGFBR1, THBS2, SMAD3, TNF, BMP6
19	Pathways in cancer20	8.9	TGFBR2, TGFBR1, MMP9, MMP2
20	MAPK Signaling36	8.7	TGFBR1, ELN, COL3A1, TNF, FBN1, BMP6
21	Colorectal Cancer Metastasis36	8.6	TGFBR2, TGFBR1, TNF, MMP9, MMP2
22	UPA-UPAR Pathway36	8.5	ELN, COL3A1, FBN1, MMP9, MMP8, MMP2
23	Metalloproteases in connective tissue degradation10	8.5	ADAMTS1, ELN, COL3A1, MMP9, MMP8, MMP2
24	Pancreatic Adenocarcinoma36	8.0	TGFBR2, TGFBR1, NOTCH1, MMP9, MMP8, MMP2
25	SMAD Signaling Network36	INF	TGFBR2, TGFBR1, ACTA2, , BMP6
26	Integrin Pathway36	INF	ELN, ACTA2, , COL3A1, FBN1
27	Germ Cell-Sertoli Cell Junction Dynamics36	INF	TGFBR2, TGFBR1, ACTA2, , TNF
28	ILK Signaling36	INF	MYH11, ELN, ACTA2, , COL3A1, TNF
29	Epithelial Adherens Junctions36	INF	MYH11, TGFBR2, TGFBR1, ACTA2, , NOTCH1
30	Antioxidant Action of Vitamin-C36	INF	MYH11, TGFBR1, ACTA2, , TNF, BMP6
31	PAK Pathway36	INF	MYH11, TGFBR1, ACTA2, , TNF, CASP4
32	MSP-RON Signaling36	INF	TNF, , ACTA2
33	Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases41	INF	ACTA2, , MYH11
34	Epithelial Tight Junctions36	INF	MYH11, TGFBR2, TGFBR1, ACTA2, , TNF
35	Transendothelial Migration of Leukocytes36	INF	MMP2, MYH11, ELN, ACTA2, , COL3A1
36	PTEN Pathway36	INF	TGFBR1, ELN, ACTA2, , COL3A1, FBN1
37	FAK1 Signaling36	INF	FBN1, COL3A1, , ACTA2, ELN
38	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases10	INF	MYH11, ACTA2,

Compounds related to thoracic aortic aneurysm according to GeneDecks:

(show top 50)    (show all 99)

id	Compound	Score	Top Affiliating Genes
1	serine32	INF	TGFBR2, ADAMTS1, MYH11, TGFBR1, THBS2, BMP6
2	bleomycin32 9 9	12.4	TGFBR2, SMAD3
3	ivig32	9.8	ELN
4	pge232	9.7	AGT, HSPA8, MMP8
5	progesterone32 42 9 18 9	13.4	MYH11, ADAMTS1, TGFBR2, TGFBR1, HMGB1, FBN1
6	hyaluronic acid32 18	10.3	BMP6, FBN1, ELN
7	h2o232	9.2	AGT, ELN, CYBA, GPX1, MMP8
8	gelfoam32	9.0	ELN, MMP9, MMP2
9	heparin32 9 18 9	11.9	ADAMTS1, TGFBR1, THBS2, AGT, ELN, HMGB1
10	(4-aminophenyl)mercuric acetate32	8.9	ELN, MMP9, MMP8, MMP2
11	cilomilast32	8.8	MMP2, MMP9, TNF
12	tranilast32	8.8	BMP6, MMP2, MMP9
13	doxycycline32 9 9	10.5	MMP2, MMP8, MMP9, NOTCH1, ELN
14	vitamin d32	8.4	TGFBR2, ELN, SMAD3, HSPA8, FBN1, BMP6
15	hydroxyproline32 18	9.3	ELN, FBN1, MMP9, MMP2, BMP6
16	oxygen32 18	9.3	AGT, NOTCH1, CYBA, HMGB1, HSPA8, GPX1
17	thymidine32 18	9.1	ADAMTS1, THBS2, AGT, COL3A1, SMAD3, TNF
18	superoxide32 18	9.1	AGT, CYBA, TNF, HMGB1, HSPA8, GPX1
19	procollagen32	7.9	THBS2, ELN, COL3A1, SMAD3, MMP9, MMP2
20	ribonucleic acid32	7.9	TGFBR2, TGFBR1, COL3A1, HSPA8, MMP9, MMP2
21	matrigel32	7.9	TGFBR1, NOTCH1, SMAD3, HMGB1, MMP9, MMP2
22	atorvastatin32 34 9 18 9	11.8	AGT, TNF, MMP9, MMP2, BMP6
23	paraffin32	7.8	MYH11, TGFBR1, AGT, ELN, HSPA8, MMP9
24	ly29400232	7.8	MYH11, TGFBR1, AGT, NOTCH1, SMAD3, TNF
25	simvastatin32 34 42 9 18 9	12.8	AGT, TNF, HSPA8, MMP9, BMP6
26	oligonucleotide32	7.7	TGFBR2, TGFBR1, THBS2, AGT, SMAD3, CYBA
27	butyrate32	7.7	SMAD3, TNF, HMGB1, HSPA8, MMP9, BMP6
28	herbimycin a32 42	8.5	TNF, HSPA8, MMP9, MMP2, BMP6
29	genistein32 9 18 9	10.5	TGFBR1, AGT, ELN, NOTCH1, TNF, MMP9
30	glutamate32	7.4	TGFBR2, COL3A1, NOTCH1, HMGB1, HSPA8, MMP9
31	cycloheximide32	7.4	TGFBR2, TGFBR1, ELN, SMAD3, TNF, MMP9
32	sb 20358032 42	8.4	AGT, SMAD3, TNF, HMGB1, MMP9, MMP2
33	pd 98,05932	7.3	AGT, SMAD3, TNF, HMGB1, MMP9, MMP2
34	cyclosporin a32 42	8.1	TGFBR2, AGT, COL3A1, TNF, HMGB1, HSPA8
35	n acetylcysteine32	7.0	AGT, ELN, SMAD3, CYBA, TNF, HSPA8
36	lactate32	6.9	ELN, TNF, HMGB1, HSPA8, MMP9, MMP8
37	tgf beta132	6.9	ADAMTS1, BMP6, MMP2, MMP9, FBN1, TNF
38	dexamethasone32 42 34 9 9	10.8	TGFBR2, TGFBR1, AGT, ELN, NOTCH1, CYBA
39	nitric oxide32 9 18 9	9.7	NOTCH1, AGT, TGFBR1, TGFBR2, MYH11, SMAD3
40	retinoic acid32 42 18	8.4	NOTCH1, ELN, TGFBR1, TGFBR2, MYH11, TNF
41	estrogen32	6.3	MYH11, TGFBR2, TGFBR1, ELN, NOTCH1, SMAD3
42	tyrosine32	INF	TGFBR2, TGFBR1, AGT, NOTCH1, SMAD3, CYBA
43	threonine32	INF
44	alanine32	INF	HSPA8, SMAD3, ELN, TGFBR1, TGFBR2, GPX1
45	cysteine32	INF	TGFBR2, THBS2, AGT, HMGB1, CASP4, HSPA8
46	lipid32	INF	SMAD3, NOTCH1, , AGT, TGFBR1, CYBA
47	proline32	INF	CYBA, NOTCH1, , ELN, HMGB1, HSPA8
48	calcium32 9 18 9	INF	CYBA, , ELN, AGT, THBS2, HMGB1
49	creatinine32	INF	AGT, ELN, , HMGB1, HSPA8, MMP9
50	vegf32	INF	MYH11, TGFBR2, THBS2, AGT, ELN, SMAD3

Cellular components related to thoracic aortic aneurysm according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	transforming growth factor beta receptor homodimeric complex	GO:070022	10.1	TGFBR1, TGFBR2
2	smooth muscle contractile fiber	GO:030485	9.8	ACTA2, MYH11
3	receptor complex	GO:043235	9.8	TGFBR2, TGFBR1, SMAD3
4	proteinaceous extracellular matrix	GO:005578	8.2	ADAMTS1, ELN, FBN1, MMP9, MMP8, MMP2
5	extracellular region	GO:005576	7.0	THBS2, AGT, COL3A1, NOTCH1, HMGB1, FBN1
6	extracellular space	GO:005615	6.5	BMP6, AGT, COL3A1, TNF, HMGB1, FBN1

Biological processes related to thoracic aortic aneurysm according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	embryonic cranial skeleton morphogenesis	GO:048701	10.2	TGFBR2, TGFBR1, SMAD3
2	glomerular mesangial cell development	GO:072144	10.1	ACTA2, NOTCH1
3	wound healing	GO:042060	9.9	SMAD3, COL3A1, TGFBR1
4	transforming growth factor beta receptor signaling pathway	GO:007179	9.8	TGFBR2, TGFBR1, COL3A1, SMAD3
5	heart development	GO:007507	9.7	TGFBR2, TGFBR1, COL3A1, NOTCH1, FBN1
6	negative regulation of osteoblast differentiation	GO:045668	9.5	TNF, SMAD3, NOTCH1
7	positive regulation of protein kinase B signaling cascade	GO:051897	9.2	TGFBR1, TNF, GPX1
8	collagen catabolic process	GO:030574	9.1	MMP9, MMP8, MMP2
9	extracellular matrix disassembly	GO:022617	9.1	MMP2, MMP8, MMP9
10	skeletal system development	GO:001501	8.7	TGFBR1, FBN1, MMP9, BMP6
11	extracellular matrix organization	GO:030198	7.6	MMP2, MMP8, MMP9, TNF, COL3A1, ELN
12	response to mechanical stimulus	GO:009612	INF	MMP9, TNF,

Molecular functions related to thoracic aortic aneurysm according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	metalloendopeptidase activity	GO:004222	8.4	MMP2, MMP8, MMP9, ADAMTS1
2	protein binding	GO:005515	INF	NOTCH1, COL3A1, , ELN, THBS2, TGFBR1