MCID: THR003
MIFTS: 50

Thoracic Aortic Aneurysm malady

Genetic diseases, Cardiovascular diseases, Rare diseases categories

Summaries for Thoracic Aortic Aneurysm

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CDC:3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso.

MalaCards based summary: Thoracic Aortic Aneurysm, also known as aortic aneurysm, thoracic, is related to aneurysm and aortic aneurysm. An important gene associated with Thoracic Aortic Aneurysm is ACTA2 (actin, alpha 2, smooth muscle, aorta), and among its related pathways are Senescence and Autophagy and Striated Muscle Contraction. The compounds procollagen and 1,25 dihydroxy vitamin d3 have been mentioned in the context of this disorder. Affiliated tissues include the thoracic aorta, heart and smooth muscle, and related mouse phenotypes are digestive/alimentary and renal/urinary system.

Disease Ontology:9 An aortic aneurysm that is located in the thoracic aorta.

Wikipedia:63 A thoracic aortic aneurysm is an aortic aneurysm that presents primarily in the thorax. more...

Aliases & Classifications for Thoracic Aortic Aneurysm

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Sources:
9Disease Ontology, 3CDC, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 27ICD9CM, 25ICD10
See all sources

Thoracic Aortic Aneurysm, Aliases & Descriptions:

Name: Thoracic Aortic Aneurysm 9 3
Aortic Aneurysm, Thoracic 60
 
Aortic Aneurysm Thoracic 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:14004
MeSH33 D017545
NCIt38 C27001
ICD9CM27 441.2
ICD1025 I71.2

Related Diseases for Thoracic Aortic Aneurysm

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Diseases in the Thoracic Aortic Aneurysm family:

Aortic Aneurysm, Familial Thoracic 7 Aortic Aneurysm, Familial Thoracic 2
Aortic Aneurysm, Familial Thoracic 8 Aortic Aneurysm, Familial Thoracic 6
Aortic Aneurysm, Familial Thoracic 1 Aortic Aneurysm, Familial Thoracic 9
Aortic Aneurysm, Familial Thoracic 4

Diseases related to Thoracic Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1aneurysm32.5COL3A1, FBN1
2aortic aneurysm32.1ACTA2, FBN1, TGFBR1
3thoracic aortic aneurysms and aortic dissections31.0TGFBR1, MYH11, ACTA2
4marfan syndrome30.8COL3A1, TGFBR1, FBN1
5ehlers-danlos syndrome30.3COL3A1, FBN1
6lung cancer30.3SMAD3, TGFBR1, TGFB2
7loeys-dietz syndrome29.8FBN1, TGFBR1, ACTA2, COL3A1
8familial thoracic aortic aneurysm and dissection11.0
9dysphagia10.7
10ischemia10.7
11paraplegia10.6
12cerebritis10.6
13esophagitis10.6
14aortic aneurysm, familial thoracic 110.5
15aortitis10.5
16abdominal aortic aneurysm10.5
17patent ductus arteriosus10.5
18wiskott-aldrich syndrome10.4
19mediastinitis10.4
20aortic coarctation10.4
21marfan syndrome/ loeys-dietz syndrome/ familial thoracic aortic aneurysms and dissections multi-gene panels10.4
22tgfbr1-related thoracic aortic aneurysms and aortic dissections10.4
23tgfbr2-related thoracic aortic aneurysms and aortic dissections10.4
24acta2-related thoracic aortic aneurysms and aortic dissections10.4
25myh11-related thoracic aortic aneurysms and aortic dissections10.4
26fbn1-related thoracic aortic aneurysms and aortic dissections10.4
27mylk-related thoracic aortic aneurysms and aortic dissections10.4
28smad3-related thoracic aortic aneurysms and aortic dissections10.4
29coronary artery disease10.3
30limb ischemia10.3
31artery disease10.3
32laryngitis10.3
33pneumonia10.3
34kommerell diverticulum10.3
35hereditary hemorrhagic telangiectasia10.3TGFBR1
36acromicric dysplasia10.3FBN1
37geleophysic dysplasia 210.2FBN1
38aortic disease10.2FBN1
39rheumatoid arthritis10.2
40systemic lupus erythematosus10.2
41aortic aneurysm, familial thoracic 810.2
42multisystemic smooth muscle dysfunction syndrome10.2
43bacteremia10.2
44arthritis10.2
45atherosclerosis10.2
46critical limb ischemia10.2
47osteoarthritis10.2
48ulcerative colitis10.2
49takayasu's arteritis10.2
50gastric ulcer10.2

Graphical network of the top 20 diseases related to Thoracic Aortic Aneurysm:



Diseases related to thoracic aortic aneurysm

Symptoms for Thoracic Aortic Aneurysm

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Drugs & Therapeutics for Thoracic Aortic Aneurysm

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Drug clinical trials:

Search ClinicalTrials for Thoracic Aortic Aneurysm

Search NIH Clinical Center for Thoracic Aortic Aneurysm

Genetic Tests for Thoracic Aortic Aneurysm

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Anatomical Context for Thoracic Aortic Aneurysm

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MalaCards organs/tissues related to Thoracic Aortic Aneurysm:

31
Heart, Smooth muscle, Lung, Spinal cord, Brain, Kidney, Thyroid, Testes

FMA organs/tissues related to Thoracic Aortic Aneurysm:

14
The thoracic aorta

Animal Models for Thoracic Aortic Aneurysm or affiliated genes

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Publications for Thoracic Aortic Aneurysm

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Articles related to Thoracic Aortic Aneurysm:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
Phenotypic switching of vascular smooth muscle cells in animal model of rat thoracic aortic aneurysm. (25829166)
2015
2
Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection. (25788370)
2015
3
Successful Emergent Endovascular Repair of a Ruptured Mycotic Thoracic Aortic Aneurysm. (25733223)
2015
4
Re: "Endovascular repair of a right-sided thoracic aortic aneurysm with Kommerell diverticulum and aberrant left subclavian artery". (24675060)
2014
5
Endovascular repair of a right-sided thoracic aortic aneurysm with Kommerell diverticulum and aberrant left subclavian artery. (24534686)
2014
6
Stent grafts separation 6 years after endovascular repair of a thoracic aortic aneurysm. (25255953)
2014
7
Left untreated: the natural course of a thoracic aortic aneurysm. (23929542)
2013
8
Hybrid treatment for thoracic aortic aneurysm combined with aberrant right subclavian artery. (23407812)
2013
9
Endovascular repair of descending thoracic aortic aneurysm in patient with Wiskott-Aldrich syndrome. (23643280)
2013
10
Appearance of thoracic aortic aneurysm on myocardial perfusion imaging. (23177336)
2013
11
Open-stent grafting with a GORE TAG thoracic endoprosthesis for an extended severely atheromatous thoracic aortic aneurysm: report of a case. (22983735)
2013
12
Antero-lateral partial sternotomy for extensive thoracic aortic aneurysm. (23243031)
2013
13
Endovascular treatment of thoracic aortic aneurysm: a single-center experience. (23790762)
2013
14
Hybrid approach to treat total thoracic aortic aneurysm in a patient undergoing emergency surgery for descending aortic rupture. (23585222)
2013
15
Late neurological recovery of paraplegia after endovascular repair of an infected thoracic aortic aneurysm. (23146426)
2013
16
Pathophysiology of thoracic aortic aneurysm (TAA): is it not one uniform aorta? Role of embryologic origin. (23993239)
2013
17
The modified chimney technique with a thoracic aortic stent graft to preserve the blood flow of the left common carotid artery for treating descending thoracic aortic aneurysm and dissection. (22701139)
2012
18
Management of a parturient with a thoracic aortic aneurysm. (21441805)
2011
19
Superior nationwide outcomes of endovascular versus open repair for isolated descending thoracic aortic aneurysm in 11,669 patients. (20951252)
2010
20
Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm in Marfan syndrome. (20189193)
2010
21
Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model. (20621845)
2010
22
Meta-analysis of open versus endovascular repair for ruptured descending thoracic aortic aneurysm. (20347700)
2010
23
Endovascular repair of descending thoracic aortic aneurysm: review of literature. (20226348)
2009
24
Single-stage repair of extended thoracic aortic aneurysm. (19074457)
2009
25
I-131 visualization of thoracic aortic aneurysm after radioiodine administration for thyroid carcinoma. (18645377)
2008
26
Successful descending thoracic aortic aneurysm repair during a twin pregnancy: case report and literature review. (17349343)
2007
27
Paradoxical orthodeoxia in a patient with a large thoracic aortic aneurysm. (17450266)
2007
28
Descending thoracic aortic aneurysm complicated with severe vertebral erosion. (17324576)
2007
29
Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. (16444274)
2006
30
Temporal disparity in the induction of matrix metalloproteinases and tissue inhibitors of metalloproteinases after thoracic aortic aneurysm formation. (17000289)
2006
31
Primary lymphoma of the aorta presenting as a descending thoracic aortic aneurysm. (16181902)
2005
32
F-18 FDG PET imaging features of a perigraft leak and thrombus in a patient with dissecting descending thoracic aortic aneurysm. (15483501)
2004
33
Simultaneous endovascular exclusion of thoracic aortic aneurysm with open abdominal aortic aneurysm repair. (15350571)
2004
34
Thoracic aortic aneurysm with aortobronchial fistula: a thirteen-year experience. (15024377)
2004
35
Cardiopulmonary bypass for thoracic aortic aneurysm: a report on 488 cases. (15095837)
2004
36
Emergent surgery for 3 aged patients who refused elective operation for thoracic aortic aneurysm. (14529161)
2003
37
Salvage of an acutely ruptured thoracic aortic aneurysm during CPR. (12166844)
2002
38
Magnetic resonance imaging of thoracic aortic aneurysm and dissection. (11715325)
2001
39
Ischemic transverse myelopathy after endovascular repair of a thoracic aortic aneurysm. (11491268)
2001
40
Special cerebral perfusion in surgery for the ruptured thoracic aortic aneurysm. (10522790)
1999
41
Descending thoracic aortic aneurysm: thoracic CT findings after endovascular stent-graft placement. (10405738)
1999
42
Geriatrics photo quiz. Thoracic aortic aneurysm. (9307570)
1997
43
Liquefaction of thrombus in thoracic aortic aneurysm: MR findings. (7785614)
1995
44
Chronic posttraumatic thoracic aortic aneurysm presenting with dysphagia. (7674415)
1995
45
Thoracic aortic aneurysm and rupture in giant cell arteritis. A descriptive study of 41 cases. (7864947)
1994
46
Aortoesophageal fistula secondary to thoracic aortic aneurysm repair. (8282742)
1993
47
Functional aortic coarctation caused by thrombosis within a thoracic aortic aneurysm. (1572887)
1992
48
Ruptured thoracic aortic aneurysm with aorto-esophageal fistula. (3950966)
1986
49
Early diagnosis of tuberculous thoracic aortic aneurysm by computerized axial tomography. (699543)
1978
50
Traumatic thoracic aortic aneurysm. Report of a case with rupture into the left subpleural space. (5016736)
1972

Variations for Thoracic Aortic Aneurysm

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Expression for genes affiliated with Thoracic Aortic Aneurysm

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Search GEO for disease gene expression data for Thoracic Aortic Aneurysm.

Pathways for genes affiliated with Thoracic Aortic Aneurysm

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Pathways related to Thoracic Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6COL3A1, SMAD3
2
Show member pathways
9.6ACTA2, MYH11
39.5COL3A1, TGFB2
49.4TGFBR1, SMAD3
5
Show member pathways
9.4SMAD3, TGFBR1
69.4SMAD3, TGFBR1
7
Show member pathways
9.4SMAD3, TGFBR1
89.4TGFBR1, SMAD3
99.4TGFBR1, SMAD3
10
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.4TGFBR1, SMAD3
11
Show member pathways
9.4TGFBR1, SMAD3
129.4TGFBR1, SMAD3
139.4SMAD3, TGFBR1
149.3TGFB2, TGFBR1
159.3TGFB2, TGFBR1
169.3TGFB2, TGFBR1
179.3TGFB2, TGFBR1
18
Show member pathways
9.3TGFB2, TGFBR1
19
Show member pathways
9.1FBN1, TGFB2
20
Show member pathways
9.0TGFBR1, TGFB2, ACTA2
21
Show member pathways
9.0ACTA2, TGFB2, TGFBR1
22
Show member pathways
9.0TGFBR1, TGFB2, ACTA2
23
Show member pathways
9.0ACTA2, TGFB2, TGFBR1
249.0ACTA2, TGFB2, TGFBR1
25
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation58
8.9TGFB2, TGFBR1, SMAD3
26
Show member pathways
8.9SMAD3, TGFBR1, TGFB2
278.9SMAD3, TGFBR1, TGFB2
28
Show member pathways
8.9SMAD3, TGFBR1, TGFB2
298.9TGFB2, TGFBR1, SMAD3
30
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.9TGFB2, TGFBR1, SMAD3
318.9TGFB2, TGFBR1, SMAD3
32
Show member pathways
8.9TGFB2, TGFBR1, SMAD3
338.9TGFB2, TGFBR1, SMAD3
348.9TGFB2, TGFBR1, SMAD3
358.9SMAD3, TGFBR1, TGFB2
36
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
8.9SMAD3, TGFBR1, TGFB2
378.9SMAD3, TGFBR1, TGFB2
38
Show member pathways
Signal transduction PTEN pathway58
8.9TGFB2, TGFBR1, SMAD3
398.9SMAD3, TGFBR1, TGFB2
40
Show member pathways
8.7FBN1, TGFB2, COL3A1
41
Show member pathways
8.4TGFBR1, TGFB2, MYH11, ACTA2
42
Show member pathways
8.4ACTA2, MYH11, TGFB2, TGFBR1
43
Show member pathways
7.7FBN1, TGFBR1, TGFB2, ACTA2, COL3A1
44
Show member pathways
7.2FBN1, TGFBR1, TGFB2, MYH11, ACTA2, COL3A1
45
Show member pathways
7.2COL3A1, ACTA2, MYH11, TGFB2, TGFBR1, FBN1

Compounds for genes affiliated with Thoracic Aortic Aneurysm

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Sources:
43Novoseek, 24HMDB, 28IUPHAR, 12DrugBank, 59Tocris Bioscience
See all sources

Compounds related to Thoracic Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 20)
idCompoundScoreTop Affiliating Genes
1procollagen439.6COL3A1, SMAD3
21,25 dihydroxy vitamin d3439.5TGFB2, SMAD3
3thymidine43 2410.2COL3A1, TGFB2, SMAD3
4dihydrotestosterone43 28 24 1212.2TGFB2, TGFBR1, SMAD3
5ribonucleic acid439.2TGFBR1, TGFB2, COL3A1
6matrigel439.1TGFB2, TGFBR1, SMAD3
7ly294002439.1SMAD3, TGFBR1, MYH11
8paraffin439.0MYH11, TGFB2, TGFBR1
9cycloheximide438.9TGFB2, TGFBR1, SMAD3
10vitamin d438.9TGFB2, FBN1, SMAD3
11vegf438.6MYH11, TGFB2, TGFBR1, SMAD3
12nitric oxide43 24 1210.6SMAD3, TGFBR1, TGFB2, MYH11
13heparin43 28 24 1211.6FBN1, TGFBR1, TGFB2
14oligonucleotide438.6TGFB2, TGFBR1, SMAD3
15tgf beta1438.4TGFB2, TGFBR1, FBN1, SMAD3
16progesterone43 28 59 24 1212.3FBN1, TGFBR1, TGFB2, MYH11
17retinoic acid43 249.2MYH11, TGFB2, TGFBR1, FBN1
18tyrosine438.0SMAD3, FBN1, TGFBR1, TGFB2
19estrogen437.9SMAD3, FBN1, TGFBR1, TGFB2, MYH11
20serine437.8SMAD3, FBN1, TGFBR1, TGFB2, MYH11

GO Terms for genes affiliated with Thoracic Aortic Aneurysm

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Cellular components related to Thoracic Aortic Aneurysm according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1smooth muscle contractile fiberGO:00304859.6ACTA2, MYH11
2receptor complexGO:00432359.4TGFBR1, SMAD3
3extracellular matrixGO:00310128.6COL3A1, TGFB2, FBN1
4extracellular spaceGO:00056158.0FBN1, TGFB2, ACTA2, COL3A1

Biological processes related to Thoracic Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of immune responseGO:00507779.8COL3A1, TGFB2
2regulation of transforming growth factor beta2 productionGO:00329099.8TGFB2, SMAD3
3positive regulation of epithelial to mesenchymal transitionGO:00107189.8TGFB2, SMAD3
4extrinsic apoptotic signaling pathwayGO:00971919.7TGFB2, SMAD3
5embryonic cranial skeleton morphogenesisGO:00487019.7TGFBR1, SMAD3
6cell-cell junction organizationGO:00452169.6TGFB2, SMAD3
7pathway-restricted SMAD protein phosphorylationGO:00603899.6TGFB2, TGFBR1
8neuron fate commitmentGO:00486639.6TGFBR1, TGFB2
9epithelial to mesenchymal transitionGO:00018379.6TGFBR1, TGFB2
10negative regulation of transforming growth factor beta receptor signaling pathwayGO:00305129.5TGFBR1, SMAD3
11negative regulation of cell growthGO:00303089.5TGFB2, SMAD3
12muscle contractionGO:00069369.5ACTA2, MYH11
13positive regulation of cell growthGO:00303079.4TGFB2, TGFBR1
14collagen fibril organizationGO:00301999.3TGFBR1, TGFB2, COL3A1
15axon guidanceGO:00074119.2TGFB2, MYH11, COL3A1
16cell cycle arrestGO:00070509.2SMAD3, TGFBR1, TGFB2
17kidney developmentGO:00018229.0FBN1, TGFBR1
18extracellular matrix disassemblyGO:00226178.9COL3A1, FBN1
19extracellular matrix organizationGO:00301988.9COL3A1, TGFB2, FBN1
20skeletal system developmentGO:00015018.9COL3A1, TGFBR1, FBN1
21wound healingGO:00420608.8COL3A1, TGFB2, TGFBR1, SMAD3
22transforming growth factor beta receptor signaling pathwayGO:00071798.8SMAD3, TGFBR1, TGFB2, COL3A1
23heart developmentGO:00075078.4COL3A1, TGFB2, TGFBR1, FBN1

Molecular functions related to Thoracic Aortic Aneurysm according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor bindingGO:00051609.5TGFB2, SMAD3
2type II transforming growth factor beta receptor bindingGO:00051149.4TGFB2, TGFBR1
3SMAD bindingGO:00463329.3COL3A1, TGFBR1
4extracellular matrix structural constituentGO:00052018.9FBN1, COL3A1
5protein bindingGO:00055157.1COL3A1, MYH11, TGFB2, TGFBR1, FBN1, SMAD3

Products for genes affiliated with Thoracic Aortic Aneurysm

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Sources for Thoracic Aortic Aneurysm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet