MCID: THR003
MIFTS: 57

Thoracic Aortic Aneurysm malady

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Thoracic Aortic Aneurysm

Aliases & Descriptions for Thoracic Aortic Aneurysm:

Name: Thoracic Aortic Aneurysm 12 29 3 14
Aortic Aneurysm, Thoracic 42 69
Aortic Aneurysm Thoracic 52

Classifications:



External Ids:

Disease Ontology 12 DOID:14004
MeSH 42 D017545
NCIt 47 C27001
SNOMED-CT 64 155421001 433068007
ICD10 33 I71.2
UMLS 69 C0162872

Summaries for Thoracic Aortic Aneurysm

CDC : 3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso.

MalaCards based summary : Thoracic Aortic Aneurysm, also known as aortic aneurysm, thoracic, is related to cerebritis and familial thoracic aortic aneurysm and dissection. An important gene associated with Thoracic Aortic Aneurysm is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Acetazolamide and Morphine have been mentioned in the context of this disorder. Affiliated tissues include heart, smooth muscle and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and cardiovascular system

Disease Ontology : 12 An aortic aneurysm that is located in the thoracic aorta.

Wikipedia : 71 A thoracic aortic aneurysm is an aortic aneurysm that presents primarily in the... more...

Related Diseases for Thoracic Aortic Aneurysm

Diseases in the Thoracic Aortic Aneurysm family:

Aortic Aneurysm, Familial Thoracic 7 Aortic Aneurysm, Familial Thoracic 2
Aortic Aneurysm, Familial Thoracic 8 Aortic Aneurysm, Familial Thoracic 6
Aortic Aneurysm, Familial Thoracic 1 Aortic Aneurysm, Familial Thoracic 9
Aortic Aneurysm, Familial Thoracic 4 Aortic Aneurysm, Familial Thoracic 11
Aortic Aneurysm, Familial Thoracic 10

Diseases related to Thoracic Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
id Related Disease Score Top Affiliating Genes
1 cerebritis 30.4 MYH11 TGFBR2
2 familial thoracic aortic aneurysm and dissection 12.6
3 aortic aneurysm 12.3
4 thoracic aortic aneurysms and aortic dissections 12.3
5 acta2-related thoracic aortic aneurysms and aortic dissections 12.1
6 myh11-related thoracic aortic aneurysms and aortic dissections 12.1
7 marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections 12.1
8 fbn1-related thoracic aortic aneurysms and aortic dissections 12.1
9 mylk-related thoracic aortic aneurysms and aortic dissections 12.1
10 tgfbr1-related thoracic aortic aneurysms and aortic dissections 12.1
11 tgfbr2-related thoracic aortic aneurysms and aortic dissections 12.1
12 prkg1-related thoracic aortic aneurysms and aortic dissections 12.0
13 mfap5-related thoracic aortic aneurysms and aortic dissections 12.0
14 smad2-related thoracic aortic aneurysms and aortic dissections 12.0
15 smad3-related thoracic aortic aneurysms and aortic dissections 12.0
16 aortic aneurysm, familial thoracic 1 11.4
17 multisystemic smooth muscle dysfunction syndrome 11.3
18 aortic aneurysm, familial thoracic 4 11.3
19 aortic aneurysm, familial thoracic 6 11.2
20 aneurysm 11.1
21 aortic aneurysm, familial thoracic 11 11.1
22 aortic aneurysm, familial thoracic 10 11.1
23 loeys-dietz syndrome 2 11.1
24 aortic aneurysm, familial thoracic 7 11.1
25 loeys-dietz syndrome 1 11.1
26 marfan syndrome 10.3
27 infective dermatitis associated with htlv-1 10.3 TGFBR1 TGFBR2
28 inflammatory breast carcinoma 10.2 TGFBR1 TGFBR2
29 adenosquamous breast carcinoma 10.2 FBN1 TGFBR2
30 ischemia 10.2
31 dysphagia 10.2
32 linear focal dermal elastosis 10.2 ELN FBN1
33 geleophysic dysplasia 2 10.2 FBN1 TGFB2
34 acute sensory ataxic neuropathy 10.2 ELN FBN1
35 acute pure sensory neuropathy 10.2 ELN FBN1
36 paraplegia 10.2
37 benign focal seizures of adolescence 10.2 ELN FBN1
38 esophagitis 10.1
39 enamel hypoplasia cataract hydrocephaly 10.1 TGFBR1 TGFBR2
40 esophagitis, eosinophilic, 1 10.1 ELN FBN1
41 human venous malformation 10.1 TGFB2 TGFBR1 TGFBR2
42 ehlers-danlos syndrome, classic type 10.1 COL3A1 ELN
43 olecranon bursitis 10.1 ELN FBN1
44 abdominal aortic aneurysm 10.0
45 aortitis 10.0
46 febrile ulceronecrotic mucha-habermann disease 10.0 FBN1 SMAD3 TGFBR1 TGFBR2
47 tinea profunda 10.0 ELN MMP2
48 myopathy-growth delay-intellectual disability-hypospadias syndrome 10.0 COL3A1 ELN FBN1
49 intellectual developmental disorder with persistence of fetal hemoglobin 10.0 SMAD3 TGFB2 TGFBR1 TGFBR2
50 patent ductus arteriosus 10.0

Graphical network of the top 20 diseases related to Thoracic Aortic Aneurysm:



Diseases related to Thoracic Aortic Aneurysm

Symptoms & Phenotypes for Thoracic Aortic Aneurysm

GenomeRNAi Phenotypes related to Thoracic Aortic Aneurysm according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.58 TGFBR2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.58 MMP2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.58 MMP2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.58 MMP2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.58 TGFBR2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.58 TGFBR2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.58 MMP2 TGFBR1 TGFBR2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.58 TGFBR1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.58 TGFBR2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.58 TGFBR1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.58 TGFBR2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.58 TGFBR1 TGFBR2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.58 TGFBR2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.58 TGFBR1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.58 TGFBR2

MGI Mouse Phenotypes related to Thoracic Aortic Aneurysm:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 ACTA2 COL3A1 FBN1 MMP2 MYH11 SMAD3
2 growth/size/body region MP:0005378 9.97 COL3A1 FBN1 MMP2 MYH11 SMAD3 TGFB2
3 homeostasis/metabolism MP:0005376 9.97 COL3A1 FBN1 MMP1 MMP2 MYH11 SMAD3
4 digestive/alimentary MP:0005381 9.88 COL3A1 MYH11 SMAD3 TGFB2 TGFBR1 TGFBR2
5 immune system MP:0005387 9.86 COL3A1 FBN1 MMP1 MMP2 SMAD3 TGFB2
6 craniofacial MP:0005382 9.83 FBN1 MMP2 SMAD3 TGFB2 TGFBR2
7 muscle MP:0005369 9.76 ACTA2 COL3A1 FBN1 MMP2 MYH11 TGFB2
8 neoplasm MP:0002006 9.35 TGFBR2 MMP1 MMP2 SMAD3 TGFBR1
9 respiratory system MP:0005388 9.17 TGFBR1 TGFBR2 COL3A1 FBN1 MMP2 MYH11

Drugs & Therapeutics for Thoracic Aortic Aneurysm

Drugs for Thoracic Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
3
Acetaminophen Approved Phase 4 103-90-2 1983
4
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
5
Levobupivacaine Approved Phase 4 27262-47-1 92253
6
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
7
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
8
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
10
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
11 Anticonvulsants Phase 4
12 Carbonic Anhydrase Inhibitors Phase 4
13 diuretics Phase 4
14 Natriuretic Agents Phase 4,Phase 3
15 Central Nervous System Depressants Phase 4
16 Antigen-Antibody Complex Phase 4
17 cadexomer iodine Phase 4
18
Iodine Phase 4 7553-56-2 807
19 Analgesics Phase 4
20 Analgesics, Opioid Phase 4
21 Narcotics Phase 4
22 Peripheral Nervous System Agents Phase 4
23 Adjuvants, Anesthesia Phase 4
24 Analgesics, Non-Narcotic Phase 4
25 Anesthetics Phase 4
26 Anesthetics, General Phase 4
27 Anesthetics, Intravenous Phase 4
28 Anesthetics, Local Phase 4
29 Antipyretics Phase 4
30 Pharmaceutical Solutions Phase 4,Phase 2
31 Neurotransmitter Agents Phase 4,Phase 2
32 Methylprednisolone acetate Phase 4
33 Methylprednisolone Hemisuccinate Phase 4
34 Prednisolone acetate Phase 4
35 Prednisolone hemisuccinate Phase 4
36 Prednisolone phosphate Phase 4
37 Adrenergic Agents Phase 4
38 Adrenergic Agonists Phase 4
39 Adrenergic alpha-2 Receptor Agonists Phase 4
40 Adrenergic alpha-Agonists Phase 4
41 Hypnotics and Sedatives Phase 4
42 histidine Nutraceutical Phase 4
43 Tryptophan Nutraceutical Phase 4
44
Losartan Approved Phase 3 114798-26-4 3961
45
Glucosamine Approved, Nutraceutical Phase 2, Phase 3 3416-24-8 439213
46 Natriuretic Peptide, Brain Phase 3
47 Anticoagulants Phase 2, Phase 3
48 Antimetabolites Phase 2, Phase 3
49 Fibrinolytic Agents Phase 2, Phase 3
50 Glucuronyl glucosamine glycan sulfate Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 144)
id Name Status NCT ID Phase
1 Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery Unknown status NCT01889498 Phase 4
2 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4
3 Endovascular Repair of Descending Thoracic Aortic Aneurysms Completed NCT00802984 Phase 4
4 Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28) Completed NCT02253082 Phase 4
5 Thoracoabdominal Arortic CTA Study Completed NCT02291718 Phase 4
6 Effects of a Surgery-induced Peripheral Inflammatory Response on the Blood Brain Barrier Completed NCT00878371 Phase 4
7 Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair Completed NCT02677532 Phase 4
8 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
9 Bloodtranfusions After Aortic Surgery Recruiting NCT02299947 Phase 4
10 CUstodiol Versus RInger: whaT Is the Best Agent? Active, not recruiting NCT02327611 Phase 4
11 Effect of Intraoperative Dexmedetomidine on Lung Not yet recruiting NCT02678728 Phase 4
12 Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4
13 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
14 ATLANTIS:Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Aneurysms Repair With LupiAe Hybrid TechNique Withdrawn NCT01107366 Phase 4
15 The Use of Nesiritide in Thoracic Aneurysm Repair to Prevent Acute Renal Failure Unknown status NCT00110201 Phase 3
16 VALOR: The Talent Thoracic Stent Graft System Clinical Study Completed NCT00604799 Phase 2, Phase 3
17 To Evaluate the Safety and Efficacy for GORE TAG Thoracic Endoprosthesis in the Treatment of Thoracic Aortic Disease Completed NCT00757003 Phase 3
18 ARBITER-II: Aorfix™ Bifurcated Safety and Performance Trial: Phase II, Angulated Vessels Completed NCT00442065 Phase 2, Phase 3
19 Study of the Efficacy of Losartan on Aortic Dilatation in Patients With Marfan Syndrome Terminated NCT00763893 Phase 3
20 Phase II Study of the Safety and Efficacy of the Relay Thoracic Stent-Graft Unknown status NCT00435942 Phase 2
21 Study of GSK1278863 to Reduce Ischemic Events in Patients Undergoing Thoracic Aortic Aneurysm Repair Completed NCT01920594 Phase 2
22 GORE TAG® Thoracic Endoprosthesis - 45 mm for the Treatment of Aneurysms of the Descending Thoracic Aorta Completed NCT00608829 Phase 2
23 Pharmacokinetics of AP214 Acetate in Patients Undergoing Cardiac Surgery Completed NCT00903604 Phase 2
24 Evaluation of the Vascutek Hybrid Graft for Use in the Replacement of the Aortic Arch and Concomitant Treatment of an Aneurysm/Dissection of the Descending Aorta in the Frozen Elephant Trunk Procedure Completed NCT01541410 Phase 1, Phase 2
25 Evaluation of Branch Endografts in the Treatment of Aortic Aneurysms Recruiting NCT01524211 Phase 2
26 Endovascular Exclusion of Thoracoabdominal and/or Paravisceral Abdominal Aortic Aneurysm Recruiting NCT00483249 Phase 1, Phase 2
27 NICardipine Neuroprotection in AortiC Surgery (NICNACS) Terminated NCT00508118 Phase 2
28 Safety, Tolerability and Pharmacodynamics of AP214 Acetate in Patients Undergoing Cardiac Surgery Terminated NCT00628264 Phase 2
29 ENTRUST - TAArget® Thoracic Stent Graft Clinical Trial Unknown status NCT01033214 Phase 1
30 South American Thoracic Stent-Graft Study Completed NCT01082172 Phase 1
31 Intraoperative Nasal Insulin Effect on Plasma and CSF Insulin Concentration and Blood Glucose Recruiting NCT02729064 Phase 1
32 Clinical Study of Thoracic Aortic Aneurysm Exclusion Unknown status NCT00549315
33 The Epidemiology of Aortic Diameter in China Unknown status NCT00820378
34 Keller Prehospital Ultrasound Study Unknown status NCT01074112
35 The Role of Alcohol Consumption in the Aetiology of Different Cardiovascular Disease Phenotypes: a CALIBER Study Unknown status NCT01864031
36 Understanding the Role of Autoimmune Disorders on the Initial Presentation of Cardiovascular Disease Unknown status NCT02062021
37 Heart Rate and Initial Presentation of Cardiovascular Diseases (Caliber) Unknown status NCT01947361
38 Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study Unknown status NCT01937065
39 Phase II Clinical Study of the Safety and Efficacy of the Relay Thoracic Stent-Graft Approved for marketing NCT01327742
40 Zenith® TX2® Low Profile TAA Endovascular Graft Approved for marketing NCT02471781
41 STARZ-TX2 Clinical Study: Study of Thoracic Aortic Aneurysm Repair With the Zenith TX2 Endovascular Graft Completed NCT00111176
42 National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions Completed NCT01322165
43 Evaluation of the GORE TAG Thoracic Endoprosthesis in the Treatment of Aneurysms Completed NCT00590759
44 Valor II: The Valiant Thoracic Stent Graft System Clinical Study Completed NCT00413231
45 Point-of-Care Focused Cardiac Ultrasound in Assessing the Thoracic Aorta Completed NCT01671618
46 Evaluation of the Safety and Efficacy of the Multilayer Stent Completed NCT01756911
47 Noninvasive Neuromonitoring of Surgery of the Thoracic Aorta Completed NCT02876263
48 Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes Completed NCT02213484
49 Post Market Surveillance Study Evaluating BioFoam Surgical Matrix in Cardiovascular Surgery Completed NCT02164201
50 Study to Determine if the Valiant Stent Graft is Safe and Effective in Treating Patients Who Have a Blunt Thoracic Aortic Injury Completed NCT01092767

Search NIH Clinical Center for Thoracic Aortic Aneurysm

Cochrane evidence based reviews: aortic aneurysm, thoracic

Genetic Tests for Thoracic Aortic Aneurysm

Genetic tests related to Thoracic Aortic Aneurysm:

id Genetic test Affiliating Genes
1 Thoracic Aortic Aneurysm 29

Anatomical Context for Thoracic Aortic Aneurysm

MalaCards organs/tissues related to Thoracic Aortic Aneurysm:

39
Heart, Smooth Muscle, Lung, Spinal Cord, Testes, Kidney, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Thoracic Aortic Aneurysm:

18
The Thoracic Aorta

Publications for Thoracic Aortic Aneurysm

Articles related to Thoracic Aortic Aneurysm:

(show top 50) (show all 671)
id Title Authors Year
1
Definitive Endovascular Repair of a Brucellar Descending Thoracic Aortic Aneurysm. ( 28513124 )
2017
2
Giant Thoracic Aortic Aneurysm Manifested as Dysphagia and Dyspnea. ( 28007285 )
2017
3
Pseudoachalasia Secondary to Thoracic Aortic Aneurysm. ( 28528055 )
2017
4
Sustained activation of ADP/P2ry12 signaling induces SMC senescence contributing to thoracic aortic aneurysm/dissection. ( 27534720 )
2016
5
Emergency Endovascular interventions for ruptured descending Thoracic Aortic Aneurysm. ( 27671448 )
2016
6
Massive Hemoptysis From an Aortobronchial Fistula Secondary to BCG-Related Mycotic Thoracic Aortic Aneurysm. ( 26694276 )
2016
7
The genetics and pathogenesis of thoracic aortic aneurysm disorder and dissections. ( 26662674 )
2016
8
Fluoroscopic-Guided Lumbar Spinal Drain Insertion for Thoracic Aortic Aneurysm Surgery. ( 28002169 )
2016
9
Hypothesis-free secretome analysis of thoracic aortic aneurysm reinforces the central role of TGF-I^ cascade in patients with bicuspid aortic valve. ( 27298013 )
2016
10
Diagnosis of a pericardial effusion with a thoracic aortic aneurysm by point-of-care ultrasound. ( 26856377 )
2016
11
The Expanding Clinical Spectrum of Extracardiovascular and Cardiovascular Manifestations of Heritable Thoracic Aortic Aneurysm and Dissection. ( 26724513 )
2016
12
Aortic Complications Associated With Pregnancy in Marfan Syndrome: The NHLBI National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC). ( 27515814 )
2016
13
Retraction of: Reversal of Spinal Cord Ischemia Following Endovascular Thoracic Aortic Aneurysm Repair with Hyperbaric Oxygen and Therapeutic Hypothermia, by Urquieta E, et al. Ther Hypothermia Temp Manag. DOI: 10.1089/ther.2015.0025. ( 27285087 )
2016
14
Thoracic aortic aneurysms in BehAset's disease. ( 27179105 )
2016
15
Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans. ( 27432961 )
2016
16
Early Experiences with the Endovascular Repair of Ruptured Descending Thoracic Aortic Aneurysm. ( 27064672 )
2016
17
Hereditary Influence in Thoracic Aortic Aneurysm and Dissection. ( 27297344 )
2016
18
Open Versus Endovascular or Hybrid Thoracic Aortic Aneurysm Repair. ( 27663901 )
2016
19
Endovascular Treatment of a Saccular Thoracic Aortic Aneurysm with Contained Rupture Inside a Para-aortic Mass. ( 27346446 )
2016
20
Open Surgery of a Descending Thoracic Aortic Aneurysm Impending Rupture with a Compression of Left Main Bronchus. ( 28018511 )
2016
21
Endovascular Repair of a Descending Thoracic Aortic Aneurysm With an Aberrant Left Subclavian Artery Associated With an Infrarenal Aortic Aneurysm. ( 27211955 )
2016
22
Vascular airway compression management in a case of aortic arch and descending thoracic aortic aneurysm. ( 27397474 )
2016
23
Advanced Glycation End Products and its Soluble Receptors in the Pathogenesis of Thoracic Aortic Aneurysm. ( 27766267 )
2016
24
Type 2 Diabetes Mellitus and Thoracic Aortic Aneurysm and Dissection: An Observational Population-Based Study in Spain From 2001 to 2012. ( 27149499 )
2016
25
FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. ( 26854927 )
2016
26
[Loeys-Dietz syndrome (TGFI^R2A mutation) in a 4-year-old child with thoracic aortic aneurysm]. ( 27017362 )
2016
27
Management of a Thoracic Aortic Aneurysm during Pregnancy Leading to the Diagnosis of Takayasu Arteritis. ( 27395815 )
2016
28
Thoracic aortic aneurysm: A rare cause of elevated hemidiaphragm. ( 27578939 )
2016
29
Characteristics of thoracic aortic aneurysm rupture in vitro. ( 27395826 )
2016
30
Thoracic Aortic Aneurysm as A Cause of Ortner's Syndrome - A Case Series. ( 27495889 )
2016
31
Secondary aorto-esophageal fistula after thoracic aortic aneurysm endovascular repair treated by covered esophageal stenting. ( 27574612 )
2016
32
Aortic rupture after thoracic endovascular repair in a patient with familial thoracic aortic aneurysm and dissections type 6 (FTAAD6). ( 27094429 )
2016
33
Infective thoracic aortic aneurysm caused by Clostridium difficile after endovascular aortic repair. ( 27578027 )
2016
34
The Investigation of a Disintegrin and Metalloproteinase with ThromboSpondin Motifs (ADAMTS) 1, 5 and 16 in Thoracic Aortic Aneurysms and Dissections. ( 27156333 )
2016
35
IMAGES IN CLINICAL MEDICINE. Vertebral-Body Erosion in Thoracic Aortic Aneurysm. ( 26962928 )
2016
36
Predicting Mid-term All-cause Mortality in Patients Undergoing Elective Endovascular Repair of a Descending Thoracic Aortic Aneurysm. ( 26813915 )
2016
37
Dissecting thoracic aortic aneurysm associated with tuberculous pleural effusion. ( 27499987 )
2016
38
Percutaneous In situ Left Subclavian Artery Fenestration Using Reentry Catheter during Endovascular Thoracic Aortic Aneurysm Repair. ( 28031661 )
2016
39
Nonsyndromic Thoracic Aortic Aneurysm and Dissection: Outcomes With Marfan Syndrome Versus Bicuspid Aortic ValveA Aneurysm. ( 26868685 )
2016
40
LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections. ( 26838787 )
2016
41
Simultaneous endovascular repairs of concomitant ruptured abdominal aortic aneurysm and huge silent thoracic aortic aneurysm. ( 27751332 )
2016
42
Preoperative Morphology Influences Thoracic Aortic Aneurysm Sac Expansion After Endovascular Repair. ( 27763272 )
2016
43
The matrix reloaded: Which pill to take to attenuate thoracic aortic aneurysm development? ( 27964978 )
2016
44
Type II endoleak after endoluminal repair of thoracic aortic aneurysm associated with native coarctation. ( 27815410 )
2016
45
Nonsyndromic thoracic aortic aneurysm and dissection: Finally answers. ( 27060273 )
2016
46
TCT-774 Comparative Outcomes Study With Thoracic Endovascular Aortic Repair on Thoracic Aortic Aneurysm vs Thoracic Aortic Dissection: Single-Center Experience. ( 27970163 )
2016
47
Bronchiectasis due to Ectopic Right Pulmonary Artery and Compression of Superior Vena Cava between Ascending Thoracic Aortic Aneurysm and Enlarged Right Pulmonary Artery. ( 27595472 )
2016
48
Chronobiology of Acute Aortic Dissection in the Marfan Syndrome (from the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions and the International Registry of Acute Aortic Dissection). ( 28065489 )
2016
49
Thoracic aortic aneurysm: a late complication of coarctation repair. ( 27123309 )
2016
50
Thoracic aortic aneurysm. ( 27563557 )
2016

Variations for Thoracic Aortic Aneurysm

Copy number variations for Thoracic Aortic Aneurysm from CNVD:

7 (show top 50) (show all 209)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 28788 1 225256 167524929 Loss BLZF1 Thoracic aortic aneurysm
2 28789 1 225256 167524929 Loss C1orf114 Thoracic aortic aneurysm
3 28790 1 225256 167524929 Loss F5 Thoracic aortic aneurysm
4 28791 1 225256 167524929 Loss SLC19A2 Thoracic aortic aneurysm
5 33382 1 449830 113015620 Gain CAPZA1 Thoracic aortic aneurysm
6 33383 1 449830 113015620 Gain FAM19A3 Thoracic aortic aneurysm
7 33384 1 449830 113015620 Gain PPM1J Thoracic aortic aneurysm
8 33385 1 449830 113015620 Gain RHOC Thoracic aortic aneurysm
9 33386 1 449830 113015620 Gain SLC16A1 Thoracic aortic aneurysm
10 33723 1 475171 1142494 Gainb ACAP3 Thoracic aortic aneurysm
11 33724 1 475171 1142494 Gainb ATAD3B Thoracic aortic aneurysm
12 33725 1 475171 1142494 Gainb ATAD3C Thoracic aortic aneurysm
13 33726 1 475171 1142494 Gainb AURKAIP1 Thoracic aortic aneurysm
14 33727 1 475171 1142494 Gainb B3GALT6 Thoracic aortic aneurysm
15 33728 1 475171 1142494 Gainb CCNL2 Thoracic aortic aneurysm
16 33729 1 475171 1142494 Gainb CDC2L1 Thoracic aortic aneurysm
17 33730 1 475171 1142494 Gainb CDC2L2 Thoracic aortic aneurysm
18 33731 1 475171 1142494 Gainb CPSF3L Thoracic aortic aneurysm
19 33732 1 475171 1142494 Gainb DVL1 Thoracic aortic aneurysm
20 33733 1 475171 1142494 Gainb GLTPD1 Thoracic aortic aneurysm
21 33734 1 475171 1142494 Gainb MIB2 Thoracic aortic aneurysm
22 33735 1 475171 1142494 Gainb MMP23B Thoracic aortic aneurysm
23 33736 1 475171 1142494 Gainb MRPL20 Thoracic aortic aneurysm
24 33737 1 475171 1142494 Gainb MXRA8 Thoracic aortic aneurysm
25 33738 1 475171 1142494 Gainb PUSL1 Thoracic aortic aneurysm
26 33739 1 475171 1142494 Gainb SCNN1D Thoracic aortic aneurysm
27 33740 1 475171 1142494 Gainb SDF4 Thoracic aortic aneurysm
28 33741 1 475171 1142494 Gainb SSU72 Thoracic aortic aneurysm
29 33742 1 475171 1142494 Gainb TAS1R3 Thoracic aortic aneurysm
30 33743 1 475171 1142494 Gainb UBE2J2 Thoracic aortic aneurysm
31 33744 1 475171 1142494 Gainb VWA1 Thoracic aortic aneurysm
32 37756 1 94386 111664830 Loss C1orf88 Thoracic aortic aneurysm
33 37757 1 94386 111664830 Loss OVGP1 Thoracic aortic aneurysm
34 38998 10 1073082 68672493 Gain ATOH7 Thoracic aortic aneurysm
35 38999 10 1073082 68672493 Gain CTNNA3 Thoracic aortic aneurysm
36 39000 10 1073082 68672493 Gain DNAJC12 Thoracic aortic aneurysm
37 39001 10 1073082 68672493 Gain HERC4 Thoracic aortic aneurysm
38 39002 10 1073082 68672493 Gain MYPN Thoracic aortic aneurysm
39 39003 10 1073082 68672493 Gain PBLD Thoracic aortic aneurysm
40 39004 10 1073082 68672493 Gain SIRT1 Thoracic aortic aneurysm
41 41305 10 158693 90129215 Loss C10orf59 Thoracic aortic aneurysm
42 45885 10 75066 63577609 Loss RTKN2 Thoracic aortic aneurysm
43 71598 12 729214 60119327 Gain TAFA2 Thoracic aortic aneurysm
44 75135 13 154705 79702503 Gain SPRY2 Thoracic aortic aneurysm
45 85139 14 391832 51343413 Gain C14orf166 Thoracic aortic aneurysm
46 85140 14 391832 51343413 Gain GNG2 Thoracic aortic aneurysm
47 85141 14 391832 51343413 Gain NID2 Thoracic aortic aneurysm
48 86796 14 65485 104688087 Loss BRF1 Thoracic aortic aneurysm
49 86797 14 65485 104688087 Loss JAG2 Thoracic aortic aneurysm
50 86798 14 65485 104688087 Loss NUDT14 Thoracic aortic aneurysm

Expression for Thoracic Aortic Aneurysm

Search GEO for disease gene expression data for Thoracic Aortic Aneurysm.

Pathways for Thoracic Aortic Aneurysm

Pathways related to Thoracic Aortic Aneurysm according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 ACTA2 COL3A1 ELN FBN1 MYH11 SMAD3
2
Show member pathways
13.61 ACTA2 MMP1 MMP2 SMAD3 TGFB2 TGFBR1
3
Show member pathways
13.21 ACTA2 MYH11 SMAD3 TGFB2 TGFBR1 TGFBR2
4
Show member pathways
12.97 ACTA2 COL3A1 ELN FBN1 TGFB2 TGFBR1
5
Show member pathways
12.85 ACTA2 MYH11 TGFB2 TGFBR1 TGFBR2
6
Show member pathways
12.8 SMAD3 TGFB2 TGFBR1 TGFBR2
7
Show member pathways
12.79 ACTA2 COL3A1 ELN FBN1 MMP1 MMP2
8
Show member pathways
12.75 ACTA2 TGFB2 TGFBR1 TGFBR2
9
Show member pathways
12.59 COL3A1 ELN FBN1 MMP1 MMP2 TGFB2
10
Show member pathways
12.53 SMAD3 TGFB2 TGFBR1 TGFBR2
11 12.51 MMP1 MMP2 SMAD3 TGFB2 TGFBR1 TGFBR2
12
Show member pathways
12.44 MMP2 SMAD3 TGFB2 TGFBR1 TGFBR2
13
Show member pathways
12.42 SMAD3 TGFB2 TGFBR1 TGFBR2
14 12.38 SMAD3 TGFB2 TGFBR1 TGFBR2
15 12.36 SMAD3 TGFB2 TGFBR1 TGFBR2
16
Show member pathways
12.29 SMAD3 TGFB2 TGFBR1 TGFBR2
17
Show member pathways
12.19 SMAD3 TGFBR1 TGFBR2
18
Show member pathways
12.16 SMAD3 TGFB2 TGFBR1 TGFBR2
19 12.14 SMAD3 TGFB2 TGFBR1
20 12.09 SMAD3 TGFB2 TGFBR1 TGFBR2
21 12.06 MMP1 TGFBR1 TGFBR2
22
Show member pathways
12.06 MMP2 SMAD3 TGFBR1 TGFBR2
23
Show member pathways
12.03 SMAD3 TGFB2 TGFBR1 TGFBR2
24
Show member pathways
12.02 SMAD3 TGFB2 TGFBR1 TGFBR2
25 12.01 ACTA2 SMAD3 TGFBR1
26 11.98 MMP1 SMAD3 TGFBR1 TGFBR2
27 11.97 TGFB2 TGFBR1 TGFBR2
28 11.85 MMP1 MMP2 SMAD3 TGFB2 TGFBR1 TGFBR2
29
Show member pathways
11.83 SMAD3 TGFBR1 TGFBR2
30
Show member pathways
11.82 SMAD3 TGFB2 TGFBR1 TGFBR2
31 11.8 MMP2 TGFB2 TGFBR1
32 11.8 SMAD3 TGFB2 TGFBR1 TGFBR2
33
Show member pathways
11.74 SMAD3 TGFBR1 TGFBR2
34
Show member pathways
11.71 ELN FBN1 TGFB2
35 11.7 SMAD3 TGFB2 TGFBR1 TGFBR2
36 11.69 SMAD3 TGFBR1 TGFBR2
37 11.69 SMAD3 TGFBR1 TGFBR2
38
Show member pathways
11.67 SMAD3 TGFBR1 TGFBR2
39 11.6 COL3A1 MMP1 MMP2
40 11.57 SMAD3 TGFBR1 TGFBR2
41 11.51 MMP1 SMAD3 TGFBR1
42 11.51 SMAD3 TGFBR1 TGFBR2
43 11.48 TGFB2 TGFBR1 TGFBR2
44 11.47 ACTA2 MMP2 SMAD3 TGFB2 TGFBR1 TGFBR2
45
Show member pathways
11.36 SMAD3 TGFB2 TGFBR1 TGFBR2
46 11.28 ACTA2 MYH11
47 11.25 TGFB2 TGFBR1
48 11.25 MMP1 MMP2
49 11.18 SMAD3 TGFB2 TGFBR1 TGFBR2
50
Show member pathways
11.14 TGFBR1 TGFBR2

GO Terms for Thoracic Aortic Aneurysm

Cellular components related to Thoracic Aortic Aneurysm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.43 SMAD3 TGFBR1 TGFBR2
2 proteinaceous extracellular matrix GO:0005578 9.35 COL3A1 ELN FBN1 MMP1 MMP2
3 transforming growth factor beta receptor complex GO:0070022 9.16 TGFBR1 TGFBR2
4 extracellular matrix GO:0031012 9.02 COL3A1 FBN1 MMP1 MMP2 TGFB2

Biological processes related to Thoracic Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 42)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 ACTA2 SMAD3 TGFB2 TGFBR1
2 cellular protein metabolic process GO:0044267 9.86 FBN1 MMP1 MMP2
3 extracellular matrix organization GO:0030198 9.86 COL3A1 ELN FBN1 TGFB2
4 in utero embryonic development GO:0001701 9.85 SMAD3 TGFBR1 TGFBR2
5 cell cycle arrest GO:0007050 9.83 SMAD3 TGFB2 TGFBR1
6 response to hypoxia GO:0001666 9.83 MMP2 SMAD3 TGFB2 TGFBR2
7 heart development GO:0007507 9.83 COL3A1 FBN1 TGFB2 TGFBR1 TGFBR2
8 kidney development GO:0001822 9.8 FBN1 TGFB2 TGFBR1
9 palate development GO:0060021 9.77 TGFB2 TGFBR1 TGFBR2
10 collagen catabolic process GO:0030574 9.77 COL3A1 MMP1 MMP2
11 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.76 SMAD3 TGFBR1 TGFBR2
12 cellular response to transforming growth factor beta stimulus GO:0071560 9.75 FBN1 SMAD3 TGFBR1
13 signal transduction by protein phosphorylation GO:0023014 9.74 TGFB2 TGFBR1 TGFBR2
14 blood vessel development GO:0001568 9.72 COL3A1 TGFB2 TGFBR2
15 skeletal system development GO:0001501 9.72 COL3A1 FBN1 SMAD3 TGFB2 TGFBR1
16 extracellular matrix disassembly GO:0022617 9.71 ELN FBN1 MMP1 MMP2
17 positive regulation of epithelial cell migration GO:0010634 9.69 TGFB2 TGFBR2
18 lens development in camera-type eye GO:0002088 9.68 TGFBR1 TGFBR2
19 digestive tract development GO:0048565 9.68 COL3A1 TGFBR2
20 gastrulation GO:0007369 9.67 SMAD3 TGFBR2
21 neuron fate commitment GO:0048663 9.67 TGFB2 TGFBR1
22 face morphogenesis GO:0060325 9.67 MMP2 TGFB2
23 collagen fibril organization GO:0030199 9.67 COL3A1 TGFB2 TGFBR1
24 outflow tract septum morphogenesis GO:0003148 9.66 TGFB2 TGFBR2
25 cell-cell junction organization GO:0045216 9.66 SMAD3 TGFB2
26 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.65 TGFBR1 TGFBR2
27 activin receptor signaling pathway GO:0032924 9.65 SMAD3 TGFBR1
28 embryonic cranial skeleton morphogenesis GO:0048701 9.65 SMAD3 TGFBR1 TGFBR2
29 ventricular trabecula myocardium morphogenesis GO:0003222 9.64 TGFB2 TGFBR1
30 negative regulation of immune response GO:0050777 9.64 COL3A1 TGFB2
31 cardiac epithelial to mesenchymal transition GO:0060317 9.63 TGFB2 TGFBR1
32 ventricular septum morphogenesis GO:0060412 9.63 TGFB2 TGFBR1 TGFBR2
33 atrioventricular valve morphogenesis GO:0003181 9.62 TGFB2 TGFBR2
34 membranous septum morphogenesis GO:0003149 9.61 TGFB2 TGFBR2
35 response to cholesterol GO:0070723 9.61 TGFBR1 TGFBR2
36 positive regulation of epithelial to mesenchymal transition GO:0010718 9.56 SMAD3 TGFB2 TGFBR1 TGFBR2
37 regulation of transforming growth factor beta2 production GO:0032909 9.54 SMAD3 TGFB2
38 pathway-restricted SMAD protein phosphorylation GO:0060389 9.54 TGFB2 TGFBR1 TGFBR2
39 endocardial cushion fusion GO:0003274 9.51 TGFB2 TGFBR2
40 wound healing GO:0042060 9.35 COL3A1 SMAD3 TGFB2 TGFBR1 TGFBR2
41 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.33 TGFB2 TGFBR1 TGFBR2
42 transforming growth factor beta receptor signaling pathway GO:0007179 9.02 COL3A1 SMAD3 TGFB2 TGFBR1 TGFBR2

Molecular functions related to Thoracic Aortic Aneurysm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta binding GO:0050431 9.4 TGFBR1 TGFBR2
2 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.37 TGFBR1 TGFBR2
3 extracellular matrix structural constituent GO:0005201 9.33 COL3A1 ELN FBN1
4 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFB2 TGFBR1
5 transforming growth factor beta-activated receptor activity GO:0005024 9.26 TGFBR1 TGFBR2
6 signal transducer, downstream of receptor, with serine/threonine kinase activity GO:0004702 9.13 TGFB2 TGFBR1 TGFBR2
7 SMAD binding GO:0046332 8.92 COL3A1 SMAD3 TGFBR1 TGFBR2

Sources for Thoracic Aortic Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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