MCID: THR003
MIFTS: 54

Thoracic Aortic Aneurysm malady

Cardiovascular category

Summaries for Thoracic Aortic Aneurysm

Sources:
3CDC, 64Wikipedia, 47OMIM, 33MalaCards
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CDC:3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso.

MalaCards: Thoracic Aortic Aneurysm, also known as thoracic aortic aneurysm without mention of rupture, is related to aortic aneurysm and aortic disease. An important gene associated with Thoracic Aortic Aneurysm is ACTA2 (actin, alpha 2, smooth muscle, aorta), and among its related pathways are Integrin Pathway and NFAT and Cardiac Hypertrophy. The compounds taad and thymosin beta4 have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and kidney, and related mouse phenotypes are respiratory system and adipose tissue.

Wikipedia:64 A thoracic aortic aneurysm is an aortic aneurysm that presents primarily in the thorax. more...

Description from OMIM:47 132900,611788

Aliases & Classifications for Thoracic Aortic Aneurysm

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 47OMIM, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

thoracic aortic aneurysm 8
thoracic aortic aneurysm without mention of rupture 8
thoracic aortic aneurysm without rupture 8
aortic aneurysm, thoracic 61
aortic aneurysm thoracic 45


External Ids:

Disease Ontology8 DOID:14004
NCIt40 C27001
MeSH35 D017545
ICD9CM27 441.2
ICD1025 I71.2

Related Diseases for Thoracic Aortic Aneurysm

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the aortic aneurysm, familial thoracic 4 family:

thoracic aortic aneurysm aortic aneurysm, familial thoracic 7
aortic aneurysm, familial thoracic 2 aortic aneurysm, familial thoracic 8
aortic aneurysm, familial thoracic 6 aortic aneurysm, familial thoracic 1

Diseases related to Thoracic Aortic Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1aortic aneurysm32.3TGFBR1, TGFBR2, ACTA2, FBN1
2aortic disease31.2FBN1
3aneurysm disease31.2MMP8, TGFBR2, COL3A1, FBN1
4marfan syndrome31.1FBN1, COL3A1, TGFBR2, TGFBR1
5thoracic aortic aneurysms and aortic dissections30.7TGFBR1, MYH11, ACTA2, TGFBR2
6intracranial aneurysm30.6COL3A1
7osteoarthritis30.2MMP8
8loeys-dietz syndrome30.2TGFBR2, COL3A1, FBN1, ACTA2, TGFBR1
9arthritis30.2S100A12, FBN1, MMP8, ADAMTS1
10atherosclerosis30.2MMP8, GPX1, MYH11, FBN1, ADAMTS1
11squamous cell carcinoma30.2THBS2, TGFBR2, GPX1, CASP4, SMAD3, TGFBR1
12familial thoracic aortic aneurysm and dissection10.9
13dissecting aortic aneurysm10.8
14dysphagia10.6
15subclavian artery aneurysm10.6
16abdominal aortic aneurysm10.6
17coronary aneurysm10.6
18aortitis10.5
19spinal cord ischemia10.5
20aortic coarctation10.5
21heart aneurysm10.5
22patent ductus arteriosus10.5
23aberrant subclavian artery10.5
24wiskott-aldrich syndrome10.4
25thoracic cancer10.4
26coronary artery aneurysm10.4
27aortic valve disease10.4
28coronary artery disease,10.3
29char syndrome10.3
30marfan syndrome/ loeys-dietz syndrome/ familial thoracic aortic aneurysms and dissections multi-gene panels10.3
31tgfbr1-related thoracic aortic aneurysms and aortic dissections10.3
32tgfbr2-related thoracic aortic aneurysms and aortic dissections10.3
33acta2-related thoracic aortic aneurysms and aortic dissections10.3
34myh11-related thoracic aortic aneurysms and aortic dissections10.3
35fbn1-related thoracic aortic aneurysms and aortic dissections10.3
36mylk-related thoracic aortic aneurysms and aortic dissections10.3
37smad3-related thoracic aortic aneurysms and aortic dissections10.3
38cholera10.2
39systemic lupus erythematosus10.2
40carotid artery dissection10.2
41takayasu's arteritis10.2
42gastric ulcer10.2
43ulcerative colitis10.2
44polymyalgia rheumatica10.2
45polycystic kidney disease10.2
46arc syndrome10.2
47aortic atherosclerosis10.2
48constrictive pericarditis10.2
49angiosarcoma10.2
50autosomal dominant disease10.2

Graphical network of the top 20 diseases related to Thoracic Aortic Aneurysm:



Diseases related to thoracic aortic aneurysm

Clinical Features for Thoracic Aortic Aneurysm

Sources:
47OMIM
See all sources

Clinical features from OMIM:

132900,611788

Drugs & Therapeutics for Thoracic Aortic Aneurysm

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Thoracic Aortic Aneurysm

Drug clinical trials:

Search ClinicalTrials for Thoracic Aortic Aneurysm

Search NIH Clinical Center for Thoracic Aortic Aneurysm

Search CenterWatch for Thoracic Aortic Aneurysm

Genetic Tests for Thoracic Aortic Aneurysm

Anatomical Context for Thoracic Aortic Aneurysm

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Thoracic Aortic Aneurysm:

33
Spinal cord, Brain, Kidney, Lung, Heart, Smooth muscle, Thyroid, B cells

Animal Models for Thoracic Aortic Aneurysm or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Thoracic Aortic Aneurysm

Sources:
51PubMed
See all sources

Articles related to Thoracic Aortic Aneurysm:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
Thoracic endovascular aortic repair with visceral arteries intermittent clamp technique for descending thoracic aortic aneurysm with shaggy aorta. (23777895)
2013
2
Identification of Three Particular Morphological Phenotypes in Sporadic Thoracic Aortic Aneurysm (S-TAA): the Phenotype III as S-TAA Biomarker in Aged Individuals. (24066724)
2013
3
Thoracic aortic aneurysm in infancy in aneurysms-osteoarthritis syndrome due to a novel SMAD3 mutation: further delineation of the phenotype. (23554019)
2013
4
Is the mean blood leukocyte telomere length a predictor for sporadic thoracic aortic aneurysm? Data from a preliminary study. (22533425)
2012
5
C-reactive protein/interleukin-6 ratio as marker of the size of the uncomplicated thoracic aortic aneurysms. (22843654)
2012
6
Treatment of a rapidly expanding thoracoabdominal aortic aneurysm after endovascular repair of descending thoracic aortic aneurysm in an old patient. (23173764)
2012
7
Successful lung lobectomy for a lung cancer following thoracic endovascular aortic repair for a thoracic aortic aneurysm: report of a case. (23266753)
2012
8
Percutaneous treatment of an infected aneurysmal sac secondary to aortoesophageal fistula with a history of stent-graft treatment for thoracic aortic aneurysm. (21853382)
2012
9
Endobronchial and endovascular management of bronchial compression by a thoracic aortic aneurysm. (22734993)
2012
10
Respecting symptoms in thoracic aortic aneurysm management: a case of symptomatic necrotizing granulomatous aortitis. (23997559)
2012
11
Image diagnosis: thoracic aortic dissection and thoracic aortic aneurysm. (21841932)
2011
12
Novel single-stage operation and inflow source: for thoracic aortic aneurysm and limb ischemia. (22163131)
2011
13
Selective microRNA suppression in human thoracic aneurysms: relationship of miR-29a to aortic size and proteolytic induction. (22010139)
2011
14
CT angiography evaluation of endoleak after thoracic endovascularaortic repair in thoracic aortic aneurysm. (20873077)
2010
15
Elective Matsui-Kitamura stent graft repair for descending thoracic aortic aneurysm and chronic type-B aortic dissection. (20680901)
2010
16
Thoracic aortic aneurysm clinically pertinent controversies and uncertainties. (20185035)
2010
17
Case of the season: aortoesophageal fistula complicating thoracic aortic aneurysm stent graft repair. (19064067)
2009
18
Predictive factors for endoleaks after thoracic aortic aneurysm endograft repair. (19660353)
2009
19
Thoracic aortic aneurysm: reading the enemy's playbook. (18273667)
2008
20
A rapidly expanding descending thoracic aortic aneurysm: an unusual complication. (18435646)
2008
21
Successful descending thoracic aortic aneurysm repair during a twin pregnancy: case report and literature review. (17349343)
2007
22
Repair of thoracic aortic aneurysm associated with tracheal and right mainstem bronchus compression. (17289487)
2007
23
Right minithoracotomy as an alternative approach for endovascular repair of thoracic aortic aneurysm. (18023693)
2007
24
Aortic debranching for descending thoracic aortic aneurysm repair by stent grafts. (17249453)
2007
25
One-step surgical approach of a thoracic aortic aneurysm in Wiskott-Aldrich syndrome. (17383380)
2007
26
The hybrid elephant trunk procedure: a single-stage repair of an ascending, arch, and descending thoracic aortic aneurysm. (16890877)
2006
27
Endovascular repair of a ruptured descending thoracic aortic aneurysm. (16878637)
2006
28
Airway obstruction secondary to thoracic aortic aneurysm leak. A case report. (16855827)
2006
29
Clinical prospective study of biochemical markers and evoked potentials for identifying adverse neurological outcome after thoracic and thoracoabdominal aortic aneurysm surgery. (16199420)
2005
30
Introduction of stent grafts in the management of patients with a abdominal or thoracic aortic aneurysm: why, perspectives, results. (15053458)
2004
31
Emergent surgery for 3 aged patients who refused elective operation for thoracic aortic aneurysm. (14529161)
2003
32
Challenges of endovascular tube graft repair of thoracic aortic aneurysm: midterm follow-up and lessons learned. (14560212)
2003
33
Cardiac function predicts mortality following thoracoabdominal and descending thoracic aortic aneurysm repair. (12853055)
2003
34
Ruptured thoracic aortic aneurysm resulting in cutaneous haematoma. (14617538)
2003
35
Minimally invasive video-assisted graft replacement of a descending thoracic aortic aneurysm. (12821441)
2003
36
Ischemic transverse myelopathy after endovascular repair of a thoracic aortic aneurysm. (11491268)
2001
37
Thoracic aortic aneurysm and dissection: surgical results and experience of 428 cases. (16352031)
2001
38
Thoracic aortic aneurysm repair: improvement in operative results and its background. (11398776)
2001
39
Descending thoracic aortic aneurysm: thoracic CT findings after endovascular stent-graft placement. (10405738)
1999
40
Transfemoral endografting of thoracic aortic aneurysm under local anesthesia: a simple, safe and fast track procedure. (10483328)
1999
41
Chronic post traumatic thoracic aortic aneurysm mimicking a benign cyst. (9727284)
1998
42
Thoracic aortic aneurysm and aortic dissection: new endoscopic mode for three-dimensional CT display of aorta. (8596868)
1996
43
Chronic posttraumatic thoracic aortic aneurysm presenting with dysphagia. (7674415)
1995
44
Loss of a right radial arterial pressure tracing during thoracic aortic aneurysm repair. (7579115)
1995
45
Comparative study of cerebral protection during surgery of thoracic aortic aneurysm. (1286973)
1992
46
Pitfalls in the diagnosis of thoracic aortic aneurysm by transesophageal echocardiography. (2334545)
1990
47
Unilateral absence of ventilation and perfusion due to thoracic aortic aneurysm. (3246118)
1988
48
Descending thoracic aortic aneurysm: a 10 year surgical experience. (6973287)
1981
49
Early diagnosis of tuberculous thoracic aortic aneurysm by computerized axial tomography. (699543)
1978
50
A case study: excision of descending thoracic aortic aneurysm and graft. (5201772)
1970

Genetic Variations for Thoracic Aortic Aneurysm

Expression for genes affiliated with Thoracic Aortic Aneurysm

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Thoracic Aortic Aneurysm

Search GEO for disease gene expression data for Thoracic Aortic Aneurysm.

Pathways for genes affiliated with Thoracic Aortic Aneurysm

Sources:
52QIAGEN, 30KEGG, 54Reactome, 53R&D Systems, 60Tocris Bioscience, 38NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore
See all sources

Pathways related to Thoracic Aortic Aneurysm according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3TGFBR2, TGFBR1
2
Hide members
10.3TGFBR2, TGFBR1
3
Hide members
10.3TGFBR1, TGFBR2
410.3TGFBR2, TGFBR1
510.3TGFBR2, TGFBR1
610.3TGFBR1, TGFBR2
7
Hide members
10.3TGFBR2, TGFBR1
8
Hide members
10.3TGFBR2, TGFBR1
9
Hide members
10.3TGFBR2, TGFBR1
10
Hide members
10.3TGFBR2, TGFBR1
1110.3ACTA1, ACTA2
1210.2TGFBR1, SMAD3, TGFBR2
1310.2TGFBR2, SMAD3, TGFBR1
1410.2SMAD3, TGFBR1, TGFBR2
1510.2TGFBR2, SMAD3, TGFBR1
16
Transcription Androgen Receptor nuclear signaling
Hide members
10.2TGFBR2, TGFBR1, SMAD3
17
Hide members
10.2TGFBR1, TGFBR2, SMAD3
18
Development TGF-beta receptor signaling
Hide members
10.2SMAD3, TGFBR1, TGFBR2
19
Hide members
10.2TGFBR1, TGFBR2, SMAD3
2010.2TGFBR1, TGFBR2, SMAD3
2110.2TGFBR1, SMAD3, TGFBR2
22
Hide members
10.2TGFBR2, SMAD3, TGFBR1
23
Cytokine production by Th17 cells in CF (Mouse model)
10.2TGFBR2, SMAD3, TGFBR1
2410.2ACTA2, MYH11, MYLK
25
Hide members
10.1MMP19, COL3A1, MMP8
2610.1TGFBR1, TGFBR2, ACTA2, ACTA1
27
Hide members
10.1MMP19, MMP8, THBS2
28
Hide members
10.1ACTA2, ACTA1, TGFBR2, MYH11
29
Hide members
10.0ACTA2, MYH11, ACTA1, MYLK
30
Hide members
10.0MYLK, MYH11, ACTA2, ACTA1
31
Cell adhesion Integrin-mediated cell adhesion and migration
Hide members
10.0ACTA2, MYLK, MYH11, ACTA1
32
Hide members
10.0ACTA1, MYH11, MYLK, ACTA2
33
Hide members
10.0FBN1, MMP8, COL3A1, MMP19
34
Hide members
9.9TGFBR1, ACTA1, COL3A1, ACTA2, FBN1
35
Cell adhesion ECM remodeling
Hide members
9.9MMP19, COL3A1, MMP8, ADAMTS1
36
Hide members
9.9ACTA2, TGFBR1, MYLK, ACTA1, CASP4
37
Hide members
9.8ACTA2, TGFBR2, ACTA1, MMP19, TGFBR1, MMP8
38
Hide members
9.7TGFBR1, TGFBR2, ACTA1, MYH11, MYLK, CASP4
39
Hide members
9.6MYH11, FBN1, ACTA1, ACTA2, MYLK, TGFBR2
40
Hide members
9.6MMP8, MYH11, MYLK, ACTA2, MMP19, FBN1

Compounds for genes affiliated with Thoracic Aortic Aneurysm

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Thoracic Aortic Aneurysm according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1taad4510.5TGFBR2, FBN1
2thymosin beta46010.3ACTA2, ACTA1
3ck 6666010.2ACTA1, ACTA2
4tgf beta14510.1THBS2, SMAD3, ADAMTS1, TGFBR2, TGFBR1, FBN1
5ly2940024510.1TGFBR1, TGFBR2, MYH11, SMAD3
6progesterone45 60 29 11 2414.0FBN1, MYH11, MMP8, ADAMTS1, TGFBR2, TGFBR1
7latrunculin a60 1111.0ACTA2, ACTA1
8nitric oxide45 11 2411.9TGFBR1, MMP8, MYH11, MYLK, GPX1, TGFBR2
9vegf459.9MYH11, MPL, MMP8, THBS2, SMAD3, TGFBR2
10threonine459.9MPL, MYLK, GPX1, SMAD3, TGFBR2, TGFBR1
11oligonucleotide459.9TGFBR1, TGFBR2, SMAD3, THBS2, MMP8, S100A12
12alanine459.9MMP8, TGFBR2, TGFBR1, SMAD3, GPX1, FBN1
13serine459.8MPL, MYLK, MYH11, MMP8, ACTA1, ADAMTS1
14glucose459.8TGFBR2, SMAD3, GPX1, MMP8, MYLK, S100A12
15cysteine459.8CASP4, THBS2, TGFBR2, MMP8, GPX1, MPL
16lipid459.7FBN1, MMP8, GPX1, ACTA1, SMAD3, TGFBR1
17calcium45 50 11 2412.3CASP4, MMP8, TGFBR2, ACTA1, THBS2, SIGMAR1

GO Terms for genes affiliated with Thoracic Aortic Aneurysm

Sources:
16Gene Ontology
See all sources

Cellular components related to Thoracic Aortic Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor homodimeric complexGO:07002210.3TGFBR2, TGFBR1
2receptor complexGO:04323510.3SMAD3, TGFBR2, TGFBR1
3smooth muscle contractile fiberGO:03048510.3MYH11, ACTA2
4stress fiberGO:00172510.0ACTA1, MYH11, MYLK
5basement membraneGO:0056049.8ADAMTS1, THBS2, FBN1
6extracellular regionGO:0055769.5THBS2, MMP19, MMP8, FBN1, MFGE8, COL3A1

Biological processes related to Thoracic Aortic Aneurysm according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1response to cholesterolGO:07072310.5TGFBR1, TGFBR2
2embryonic cranial skeleton morphogenesisGO:04870110.4TGFBR1, TGFBR2, SMAD3
3negative regulation of transforming growth factor beta receptor signaling pathwayGO:03051210.4SMAD3, TGFBR2, TGFBR1
4ovulation from ovarian follicleGO:00154210.4ADAMTS1, MMP19
5wound healingGO:04206010.3TGFBR1, TGFBR2, SMAD3, COL3A1
6muscle contractionGO:00693610.3MYLK, MYH11, ACTA1, ACTA2
7transforming growth factor beta receptor signaling pathwayGO:00717910.3COL3A1, SMAD3, TGFBR2, TGFBR1
8heart developmentGO:00750710.3TGFBR1, TGFBR2, FBN1, COL3A1
9pathway-restricted SMAD protein phosphorylationGO:06038910.3TGFBR2, TGFBR1
10collagen catabolic processGO:03057410.2COL3A1, MMP8, MMP19
11extracellular matrix disassemblyGO:02261710.2MMP19, MMP8, COL3A1
12skeletal system developmentGO:00150110.2TGFBR1, FBN1, COL3A1
13skeletal muscle fiber developmentGO:04874110.1GPX1, ACTA1
14extracellular matrix organizationGO:03019810.1COL3A1, FBN1, MMP8, MMP19
15regulation of neuron apoptotic processGO:0435239.9SIGMAR1, GPX1

Molecular functions related to Thoracic Aortic Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein serine/threonine kinase activityGO:00467510.3TGFBR1, TGFBR2
2transforming growth factor beta bindingGO:05043110.3TGFBR2, TGFBR1
3SMAD bindingGO:04633210.3COL3A1, TGFBR2, TGFBR1
4transforming growth factor beta-activated receptor activityGO:00502410.2TGFBR1, TGFBR2
5calcium ion bindingGO:0055099.8MMP8, FBN1, S100A12, THBS2, MMP19
6metalloendopeptidase activityGO:0042229.8ADAMTS1, MMP8, MMP19

Products for genes affiliated with Thoracic Aortic Aneurysm

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thoracic Aortic Aneurysm

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet