MCID: THR027
MIFTS: 31

Thoracic Aortic Aneurysms and Aortic Dissections malady

Summaries for Thoracic Aortic Aneurysms and Aortic Dissections

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19GeneReviews, 33MalaCards
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MalaCards: Thoracic Aortic Aneurysms and Aortic Dissections is related to thoracic aortic aneurysm and aortic aneurysm. An important gene associated with Thoracic Aortic Aneurysms and Aortic Dissections is TGFBR2 (transforming growth factor, beta receptor II (70/80kDa)), and among its related pathways are Toll-like receptor signaling pathway and NFAT and Cardiac Hypertrophy. The compounds taad and dihydrotestosterone have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and renal/urinary system.

GeneReviews summary for taa

Aliases & Classifications for Thoracic Aortic Aneurysms and Aortic Dissections

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19GeneReviews, 20GeneTests, 22GTR
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Aliases & Descriptions:

thoracic aortic aneurysms and aortic dissections 19 20 22


Related Diseases for Thoracic Aortic Aneurysms and Aortic Dissections

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17GeneCards, 18GeneDecks
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Diseases related to Thoracic Aortic Aneurysms and Aortic Dissections via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 35)
idRelated DiseaseScoreTop Affiliating Genes
1thoracic aortic aneurysm31.1TGFBR2, MYH11, FBN1
2aortic aneurysm31.1TGFBR2, FBN1, TGFBR1, ACTA2
3tgfbr1-related thoracic aortic aneurysms and aortic dissections10.6
4tgfbr2-related thoracic aortic aneurysms and aortic dissections10.6
5acta2-related thoracic aortic aneurysms and aortic dissections10.6
6myh11-related thoracic aortic aneurysms and aortic dissections10.6
7fbn1-related thoracic aortic aneurysms and aortic dissections10.6
8mylk-related thoracic aortic aneurysms and aortic dissections10.6
9smad3-related thoracic aortic aneurysms and aortic dissections10.6
10aortic aneurysm, familial thoracic 410.4
11aortic disease10.0FBN1
12hereditary hemorrhagic telangiectasia10.0TGFBR1
13lichen planus10.0FBN1
14asthma10.0MYLK
15endometrial carcinoma10.0TGFBR2
16cleft palate10.0TGFBR1, TGFBR2
17primary pulmonary hypertension10.0FBN1
18aneurysm disease10.0TGFBR2, FBN1
19telangiectasis10.0TGFBR1, FBN1
20mental retardation10.0TGFBR2, FBN1
21glomerulonephritis10.0TGFBR2, TGFBR1
22connective tissue disease10.0FBN1, TGFBR2
23myeloid leukemia10.0MYH11
24adenoma10.0TGFBR2, TGFBR1
25pulmonary fibrosis10.0SMAD3, TGFBR2
26marfan syndrome10.0TGFBR1, FBN1, TGFBR2
27keloids10.0SMAD3, TGFBR1
28diabetic nephropathy10.0SMAD3, TGFBR2, TGFBR1
29prostate cancer10.0SMAD3, TGFBR2, TGFBR1
30pancreatic cancer10.0TGFBR2, SMAD3, TGFBR1
31hypertrophic scars10.0SMAD3, TGFBR2, FBN1
32squamous cell carcinoma of the head and neck10.0SMAD3, TGFBR2, TGFBR1
33loeys-dietz syndrome10.0TGFBR1, TGFBR2, ACTA2, FBN1
34systemic scleroderma10.0TGFBR1, SMAD3, FBN1
35breast cancer10.0TGFBR1, TGFBR2, SMAD3, MYH11

Graphical network of the top 20 diseases related to Thoracic Aortic Aneurysms and Aortic Dissections:



Diseases related to thoracic aortic aneurysms and aortic dissections

Clinical Features for Thoracic Aortic Aneurysms and Aortic Dissections

Drugs & Therapeutics for Thoracic Aortic Aneurysms and Aortic Dissections

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Thoracic Aortic Aneurysms and Aortic Dissections

Drug clinical trials:

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Search NIH Clinical Center for Thoracic Aortic Aneurysms and Aortic Dissections

Search CenterWatch for Thoracic Aortic Aneurysms and Aortic Dissections

Genetic Tests for Thoracic Aortic Aneurysms and Aortic Dissections

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20GeneTests, 22GTR
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Genetic tests related to Thoracic Aortic Aneurysms and Aortic Dissections:

id Genetic test Affiliating Genes
1 Thoracic Aortic Aneurysms And Aortic Dissections20 22 TGFBR2

Anatomical Context for Thoracic Aortic Aneurysms and Aortic Dissections

Animal Models for Thoracic Aortic Aneurysms and Aortic Dissections or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Thoracic Aortic Aneurysms and Aortic Dissections

Genetic Variations for Thoracic Aortic Aneurysms and Aortic Dissections

Expression for genes affiliated with Thoracic Aortic Aneurysms and Aortic Dissections

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thoracic Aortic Aneurysms and Aortic Dissections

Search GEO for disease gene expression data for Thoracic Aortic Aneurysms and Aortic Dissections.

Pathways for genes affiliated with Thoracic Aortic Aneurysms and Aortic Dissections

Sources:
38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 53R&D Systems, 60Tocris Bioscience, 54Reactome, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Thoracic Aortic Aneurysms and Aortic Dissections according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.6TGFBR1, TGFBR2
2
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9.6TGFBR1, TGFBR2
39.6TGFBR1, TGFBR2
49.6TGFBR1, TGFBR2
5
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9.6TGFBR1, TGFBR2
69.6TGFBR1, TGFBR2
7
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9.6TGFBR1, TGFBR2
8
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9.6TGFBR1, TGFBR2
99.6TGFBR2, TGFBR1
10
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9.6TGFBR2, TGFBR1
11
Hide members
9.6TGFBR2, TGFBR1
129.6TGFBR2, TGFBR1
139.6TGFBR2, TGFBR1
14
Hide members
9.6TGFBR2, TGFBR1
159.2TGFBR1, TGFBR2, ACTA2
169.2TGFBR1, SMAD3
17
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.2TGFBR1, SMAD3
189.2TGFBR1, SMAD3
19
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9.2TGFBR2, ACTA2, MYH11
20
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9.1TGFBR1, ACTA2, FBN1
21
Cell adhesion Integrin-mediated cell adhesion and migration
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8.9ACTA2, MYH11, MYLK
22
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8.9ACTA2, MYH11, MYLK
23
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8.9ACTA2, MYH11, MYLK
248.9MYLK, MYH11, ACTA2
25
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8.9MYLK, MYH11, ACTA2
268.8SMAD3, TGFBR2, TGFBR1
27
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8.8SMAD3, TGFBR2, TGFBR1
288.8TGFBR1, TGFBR2, SMAD3
298.8SMAD3, TGFBR2, TGFBR1
30
Development TGF-beta receptor signaling
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8.8SMAD3, TGFBR2, TGFBR1
318.8TGFBR1, TGFBR2, SMAD3
328.8TGFBR1, TGFBR2, SMAD3
33
Cytokine production by Th17 cells in CF (Mouse model)
8.8SMAD3, TGFBR2, TGFBR1
348.8TGFBR1, TGFBR2, SMAD3
35
Cell cycle Cell cycle (generic schema)
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8.8SMAD3, TGFBR2, TGFBR1
36
Hide members
8.8SMAD3, TGFBR2, TGFBR1
378.8TGFBR1, TGFBR2, SMAD3
388.8SMAD3, TGFBR2, TGFBR1
39
Transcription Androgen Receptor nuclear signaling
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8.8TGFBR1, TGFBR2, SMAD3
40
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8.8TGFBR1, TGFBR2, SMAD3
418.8TGFBR1, TGFBR2, SMAD3
42
Hide members
8.4FBN1, MYLK, MYH11, ACTA2
43
Hide members
8.1MYLK, MYH11, ACTA2, TGFBR2, TGFBR1
44
Hide members
7.6TGFBR1, TGFBR2, ACTA2, MYH11, MYLK, FBN1

Compounds for genes affiliated with Thoracic Aortic Aneurysms and Aortic Dissections

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
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Compounds related to Thoracic Aortic Aneurysms and Aortic Dissections according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1taad459.8TGFBR2, FBN1
2dihydrotestosterone45 29 11 2412.0SMAD3, TGFBR2, TGFBR1
3progesterone45 60 29 11 2412.8TGFBR1, TGFBR2, MYH11, FBN1
4vitamin d458.7TGFBR2, SMAD3, FBN1
5tgf beta1458.6TGFBR1, TGFBR2, SMAD3, FBN1
6tyrosine458.6TGFBR1, TGFBR2, MYLK, FBN1
7ly294002458.5TGFBR1, TGFBR2, SMAD3, MYH11
8vegf458.4MYH11, SMAD3, TGFBR2, TGFBR1
9retinoic acid45 249.3FBN1, MYH11, TGFBR2, TGFBR1
10threonine458.2MYLK, SMAD3, TGFBR2, TGFBR1
11glucose458.2TGFBR1, TGFBR2, SMAD3, MYLK
12nitric oxide45 11 249.9MYLK, MYH11, SMAD3, TGFBR2, TGFBR1
13alanine457.9FBN1, MYLK, SMAD3, TGFBR2, TGFBR1
14serine457.4FBN1, MYLK, MYH11, SMAD3, TGFBR2, TGFBR1

GO Terms for genes affiliated with Thoracic Aortic Aneurysms and Aortic Dissections

Sources:
16Gene Ontology
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Cellular components related to Thoracic Aortic Aneurysms and Aortic Dissections according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor homodimeric complexGO:0700229.6TGFBR2, TGFBR1
2smooth muscle contractile fiberGO:0304859.4MYH11, ACTA2
3stress fiberGO:0017259.0MYLK, MYH11
4receptor complexGO:0432358.9SMAD3, TGFBR2, TGFBR1
5cytosolGO:0058297.7MYLK, MYH11, ACTA2, SMAD3, TGFBR2

Biological processes related to Thoracic Aortic Aneurysms and Aortic Dissections according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1response to cholesterolGO:0707239.9TGFBR2, TGFBR1
2pathway-restricted SMAD protein phosphorylationGO:0603899.8TGFBR1, TGFBR2
3lens development in camera-type eyeGO:0020889.7TGFBR2, TGFBR1
4peptidyl-threonine phosphorylationGO:0181079.6TGFBR2, TGFBR1
5palate developmentGO:0600219.6TGFBR1, TGFBR2
6smooth muscle contractionGO:0069399.5MYH11, MYLK
7peptidyl-serine phosphorylationGO:0181059.3TGFBR2, TGFBR1
8heart developmentGO:0075079.3FBN1, TGFBR2, TGFBR1
9muscle contractionGO:0069369.2ACTA2, MYH11, MYLK
10embryonic cranial skeleton morphogenesisGO:0487019.1TGFBR1, TGFBR2, SMAD3
11wound healingGO:0420609.1SMAD3, TGFBR2, TGFBR1
12negative regulation of transforming growth factor beta receptor signaling pathwayGO:0305129.1SMAD3, TGFBR2, TGFBR1
13transforming growth factor beta receptor signaling pathwayGO:0071799.0TGFBR1, TGFBR2, SMAD3
14in utero embryonic developmentGO:0017018.9TGFBR2, SMAD3, TGFBR1
15protein phosphorylationGO:0064688.9TGFBR1, TGFBR2, MYLK

Molecular functions related to Thoracic Aortic Aneurysms and Aortic Dissections according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein serine/threonine kinase activityGO:0046759.7TGFBR1, TGFBR2
2transforming growth factor beta bindingGO:0504319.6TGFBR1, TGFBR2
3SMAD bindingGO:0463329.6TGFBR1, TGFBR2
4transforming growth factor beta-activated receptor activityGO:0050249.5TGFBR2, TGFBR1
5ATP bindingGO:0055247.8TGFBR1, TGFBR2, MYH11, MYLK, ACTA2

Products for genes affiliated with Thoracic Aortic Aneurysms and Aortic Dissections

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  • Proteins
  • Lysates
  • Antibodies

Sources for Thoracic Aortic Aneurysms and Aortic Dissections

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet