MCID: THR027
MIFTS: 33

Thoracic Aortic Aneurysms and Aortic Dissections malady

Summaries for Thoracic Aortic Aneurysms and Aortic Dissections

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19GeneReviews, 32MalaCards
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MalaCards: Thoracic Aortic Aneurysms and Aortic Dissections is related to thoracic aortic aneurysm and aortic aneurysm. An important gene associated with Thoracic Aortic Aneurysms and Aortic Dissections is TGFBR2 (transforming growth factor, beta receptor II (70/80kDa)), and among its related pathways are Toll-like receptor signaling pathway and NFAT and Cardiac Hypertrophy. The compounds taad and dihydrotestosterone have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and renal/urinary system.

GeneReviews summary for taa

Aliases & Classifications for Thoracic Aortic Aneurysms and Aortic Dissections

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19GeneReviews, 20GeneTests
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Aliases & Descriptions:

thoracic aortic aneurysms and aortic dissections 19 20


Related Diseases for Thoracic Aortic Aneurysms and Aortic Dissections

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17GeneCards, 18GeneDecks
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Diseases in the Thoracic Aortic Aneurysms and Aortic Dissections family:

Tgfbr1-Related Thoracic Aortic Aneurysms and Aortic Dissections Tgfbr2-Related Thoracic Aortic Aneurysms and Aortic Dissections
Acta2-Related Thoracic Aortic Aneurysms and Aortic Dissections Myh11-Related Thoracic Aortic Aneurysms and Aortic Dissections
Fbn1-Related Thoracic Aortic Aneurysms and Aortic Dissections Mylk-Related Thoracic Aortic Aneurysms and Aortic Dissections
Smad3-Related Thoracic Aortic Aneurysms and Aortic Dissections

Diseases related to Thoracic Aortic Aneurysms and Aortic Dissections via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1thoracic aortic aneurysm31.1TGFBR2, MYH11, FBN1
2aortic aneurysm31.1FBN1, ACTA2, TGFBR2, TGFBR1
3dissecting aortic aneurysm10.8
4tgfbr1-related thoracic aortic aneurysms and aortic dissections10.6
5tgfbr2-related thoracic aortic aneurysms and aortic dissections10.6
6acta2-related thoracic aortic aneurysms and aortic dissections10.6
7myh11-related thoracic aortic aneurysms and aortic dissections10.6
8fbn1-related thoracic aortic aneurysms and aortic dissections10.6
9mylk-related thoracic aortic aneurysms and aortic dissections10.6
10smad3-related thoracic aortic aneurysms and aortic dissections10.6
11pneumonia10.4
12aortic aneurysm, familial thoracic 410.4
13aortic disease10.0FBN1
14hereditary hemorrhagic telangiectasia10.0TGFBR1
15lichen planus10.0FBN1
16asthma10.0MYLK
17endometrial carcinoma10.0TGFBR2
18cleft palate10.0TGFBR2, TGFBR1
19primary pulmonary hypertension10.0FBN1
20aneurysm disease10.0FBN1, TGFBR2
21telangiectasis10.0TGFBR1, FBN1
22mental retardation10.0FBN1, TGFBR2
23glomerulonephritis10.0TGFBR1, TGFBR2
24connective tissue disease10.0TGFBR2, FBN1
25myeloid leukemia10.0MYH11
26adenoma10.0TGFBR2, TGFBR1
27pulmonary fibrosis10.0TGFBR2, SMAD3
28marfan syndrome10.0TGFBR1, TGFBR2, FBN1
29keloids10.0TGFBR1, SMAD3
30diabetic nephropathy10.0SMAD3, TGFBR2, TGFBR1
31prostate cancer10.0TGFBR1, TGFBR2, SMAD3
32pancreatic cancer10.0TGFBR1, TGFBR2, SMAD3
33hypertrophic scars10.0FBN1, SMAD3, TGFBR2
34squamous cell carcinoma of the head and neck10.0SMAD3, TGFBR2, TGFBR1
35loeys-dietz syndrome10.0TGFBR1, TGFBR2, ACTA2, FBN1
36systemic scleroderma10.0FBN1, SMAD3, TGFBR1
37breast cancer10.0MYH11, SMAD3, TGFBR2, TGFBR1

Graphical network of the top 20 diseases related to Thoracic Aortic Aneurysms and Aortic Dissections:



Diseases related to thoracic aortic aneurysms and aortic dissections

Clinical Features for Thoracic Aortic Aneurysms and Aortic Dissections

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Drugs & Therapeutics for Thoracic Aortic Aneurysms and Aortic Dissections

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Thoracic Aortic Aneurysms and Aortic Dissections

Drug clinical trials:

Search ClinicalTrials for Thoracic Aortic Aneurysms and Aortic Dissections

Search NIH Clinical Center for Thoracic Aortic Aneurysms and Aortic Dissections

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Genetic Tests for Thoracic Aortic Aneurysms and Aortic Dissections

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20GeneTests, 22GTR
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Genetic tests related to Thoracic Aortic Aneurysms and Aortic Dissections:

id Genetic test Affiliating Genes
1 Thoracic Aortic Aneurysms and Aortic Dissections20 22 TGFBR2

Anatomical Context for Thoracic Aortic Aneurysms and Aortic Dissections

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Animal Models for Thoracic Aortic Aneurysms and Aortic Dissections or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thoracic Aortic Aneurysms and Aortic Dissections:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.5TGFBR1, TGFBR2
2MP:00053678.0FBN1, MYLK, MYH11, SMAD3
3MP:00053907.9FBN1, MYLK, SMAD3, TGFBR2, TGFBR1
4MP:00053817.8MYLK, MYH11, SMAD3, TGFBR2
5MP:00053697.8FBN1, MYLK, MYH11, ACTA2, TGFBR2, TGFBR1
6MP:00053877.7TGFBR1, TGFBR2, SMAD3, MYLK, FBN1
7MP:00053787.3FBN1, MYLK, MYH11, SMAD3, TGFBR2, TGFBR1
8MP:00053767.3FBN1, MYLK, MYH11, SMAD3, TGFBR2, TGFBR1
9MP:00107687.2FBN1, MYLK, MYH11, SMAD3, TGFBR2, TGFBR1
10MP:00053857.0TGFBR1, FBN1, MYLK, MYH11, ACTA2, SMAD3

Publications for Thoracic Aortic Aneurysms and Aortic Dissections

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Genetic Variations for Thoracic Aortic Aneurysms and Aortic Dissections

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Expression for genes affiliated with Thoracic Aortic Aneurysms and Aortic Dissections

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thoracic Aortic Aneurysms and Aortic Dissections

Search GEO for disease gene expression data for Thoracic Aortic Aneurysms and Aortic Dissections.

Pathways for genes affiliated with Thoracic Aortic Aneurysms and Aortic Dissections

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Sources:
37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 52R&D Systems, 59Tocris Bioscience, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Thoracic Aortic Aneurysms and Aortic Dissections according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.6TGFBR1, TGFBR2
2
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9.6TGFBR1, TGFBR2
39.6TGFBR1, TGFBR2
49.6TGFBR1, TGFBR2
5
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9.6TGFBR1, TGFBR2
69.6TGFBR1, TGFBR2
7
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9.6TGFBR1, TGFBR2
8
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9.6TGFBR1, TGFBR2
99.6TGFBR2, TGFBR1
10
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9.6TGFBR2, TGFBR1
11
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9.6TGFBR2, TGFBR1
129.6TGFBR2, TGFBR1
139.6TGFBR2, TGFBR1
14
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9.6TGFBR2, TGFBR1
159.2TGFBR1, TGFBR2, ACTA2
169.2TGFBR1, SMAD3
17
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.2TGFBR1, SMAD3
189.2TGFBR1, SMAD3
19
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9.2TGFBR2, ACTA2, MYH11
20
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9.1TGFBR1, ACTA2, FBN1
21
Cell adhesion Integrin-mediated cell adhesion and migration
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8.9ACTA2, MYH11, MYLK
22
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8.9ACTA2, MYH11, MYLK
23
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8.9ACTA2, MYH11, MYLK
248.9MYLK, MYH11, ACTA2
25
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8.9MYLK, MYH11, ACTA2
268.8SMAD3, TGFBR2, TGFBR1
27
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8.8SMAD3, TGFBR2, TGFBR1
288.8TGFBR1, TGFBR2, SMAD3
298.8SMAD3, TGFBR2, TGFBR1
30
Development TGF-beta receptor signaling
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8.8SMAD3, TGFBR2, TGFBR1
318.8TGFBR1, TGFBR2, SMAD3
328.8TGFBR1, TGFBR2, SMAD3
33
Cytokine production by Th17 cells in CF (Mouse model)
8.8SMAD3, TGFBR2, TGFBR1
348.8TGFBR1, TGFBR2, SMAD3
35
Cell cycle Cell cycle (generic schema)
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8.8SMAD3, TGFBR2, TGFBR1
36
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8.8SMAD3, TGFBR2, TGFBR1
378.8TGFBR1, TGFBR2, SMAD3
388.8SMAD3, TGFBR2, TGFBR1
39
Transcription Androgen Receptor nuclear signaling
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8.8TGFBR1, TGFBR2, SMAD3
40
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8.8TGFBR1, TGFBR2, SMAD3
418.8TGFBR1, TGFBR2, SMAD3
42
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8.4FBN1, MYLK, MYH11, ACTA2
43
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8.1MYLK, MYH11, ACTA2, TGFBR2, TGFBR1
44
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7.6TGFBR1, TGFBR2, ACTA2, MYH11, MYLK, FBN1

Compounds for genes affiliated with Thoracic Aortic Aneurysms and Aortic Dissections

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Thoracic Aortic Aneurysms and Aortic Dissections according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1taad449.8TGFBR2, FBN1
2dihydrotestosterone44 28 11 2412.0SMAD3, TGFBR2, TGFBR1
3progesterone44 59 28 11 2412.8TGFBR1, TGFBR2, MYH11, FBN1
4vitamin d448.7TGFBR2, SMAD3, FBN1
5tgf beta1448.6TGFBR1, TGFBR2, SMAD3, FBN1
6tyrosine448.6TGFBR1, TGFBR2, MYLK, FBN1
7ly294002448.5TGFBR1, TGFBR2, SMAD3, MYH11
8vegf448.4MYH11, SMAD3, TGFBR2, TGFBR1
9retinoic acid44 249.3FBN1, MYH11, TGFBR2, TGFBR1
10threonine448.2MYLK, SMAD3, TGFBR2, TGFBR1
11glucose448.2TGFBR1, TGFBR2, SMAD3, MYLK
12nitric oxide44 11 249.9MYLK, MYH11, SMAD3, TGFBR2, TGFBR1
13alanine447.9FBN1, MYLK, SMAD3, TGFBR2, TGFBR1
14serine447.4FBN1, MYLK, MYH11, SMAD3, TGFBR2, TGFBR1

GO Terms for genes affiliated with Thoracic Aortic Aneurysms and Aortic Dissections

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16Gene Ontology
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Cellular components related to Thoracic Aortic Aneurysms and Aortic Dissections according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1smooth muscle contractile fiberGO:0304859.5ACTA2, MYH11
2transforming growth factor beta receptor homodimeric complexGO:0700229.5TGFBR1, TGFBR2
3stress fiberGO:0017259.0MYLK, MYH11
4receptor complexGO:0432358.9TGFBR1, TGFBR2, SMAD3
5cytosolGO:0058297.7TGFBR2, SMAD3, ACTA2, MYH11, MYLK

Biological processes related to Thoracic Aortic Aneurysms and Aortic Dissections according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1response to cholesterolGO:0707239.9TGFBR1, TGFBR2
2pathway-restricted SMAD protein phosphorylationGO:0603899.8TGFBR1, TGFBR2
3lens development in camera-type eyeGO:0020889.7TGFBR2, TGFBR1
4peptidyl-threonine phosphorylationGO:0181079.6TGFBR1, TGFBR2
5palate developmentGO:0600219.6TGFBR1, TGFBR2
6smooth muscle contractionGO:0069399.5MYH11, MYLK
7peptidyl-serine phosphorylationGO:0181059.3TGFBR1, TGFBR2
8heart developmentGO:0075079.3FBN1, TGFBR2, TGFBR1
9muscle contractionGO:0069369.2MYLK, MYH11, ACTA2
10embryonic cranial skeleton morphogenesisGO:0487019.1TGFBR1, TGFBR2, SMAD3
11wound healingGO:0420609.1SMAD3, TGFBR2, TGFBR1
12negative regulation of transforming growth factor beta receptor signaling pathwayGO:0305129.1TGFBR1, TGFBR2, SMAD3
13transforming growth factor beta receptor signaling pathwayGO:0071799.0TGFBR1, TGFBR2, SMAD3
14in utero embryonic developmentGO:0017018.9TGFBR1, TGFBR2, SMAD3
15protein phosphorylationGO:0064688.9MYLK, TGFBR2, TGFBR1

Molecular functions related to Thoracic Aortic Aneurysms and Aortic Dissections according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein serine/threonine kinase activityGO:0046759.7TGFBR1, TGFBR2
2transforming growth factor beta bindingGO:0504319.6TGFBR1, TGFBR2
3SMAD bindingGO:0463329.6TGFBR1, TGFBR2
4transforming growth factor beta-activated receptor activityGO:0050249.5TGFBR1, TGFBR2
5ATP bindingGO:0055247.8MYLK, MYH11, ACTA2, TGFBR2, TGFBR1

Products for genes affiliated with Thoracic Aortic Aneurysms and Aortic Dissections

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Sources for Thoracic Aortic Aneurysms and Aortic Dissections

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet