MCID: THR012
MIFTS: 54

Thoracic Cancer malady

Cancer diseases, Respiratory diseases categories

Summaries for Thoracic Cancer

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Disease Ontology:10 An organ system cancer located in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.

MalaCards based summary: Thoracic Cancer, also known as tumor of thorax, is related to malignant pleural mesothelioma and lung cancer. An important gene associated with Thoracic Cancer is CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1)), and among its related pathways are Death Receptor Signalling and Activation of caspases through apoptosome-mediated cleavage. The compounds perifosine and cccp have been mentioned in the context of this disorder. Affiliated tissues include the thoracic cavity, lung and trachea, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Thoracic Cancer

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Sources:
10Disease Ontology, 45Novoseek, 62UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Thoracic Cancer, Aliases & Descriptions:

Name: Thoracic Cancer 10 45
Tumor of Thorax 10 62
Malignant Neoplasm of Thorax 62
Malignant Neoplasms 62
 
Thoracic Neoplasms 62
Thorax Neoplasm 10
Thoracic Tumor 10
Thorax Cancer 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology10 DOID:5093
NCIt40 C3406
MeSH35 D013899

Related Diseases for Thoracic Cancer

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Diseases in the Thoracic Cancer family:

Thoracic Benign Neoplasm

Diseases related to Thoracic Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1malignant pleural mesothelioma29.9TYMS, MSLN
2lung cancer29.9PTGS2, CDKN1A, TYMS
3endometriosis29.9CASP9, KDR, PTGS2
4mesothelioma29.9TKT, MSLN, TYMS, TNFSF10
5breast cancer29.7CDKN1A, CASP9, SLC2A1, CASP3, KDR, TYMS
6capillary hemangioma10.1SLC2A1
7myocardial infarction10.0PTGS2
8thyroid carcinoma, follicular10.0KDR, CDKN1A
9benign mesothelioma10.0TYMS, MSLN
10rectal neoplasm10.0CDKN1A, TYMS
11hemangioblastoma10.0SLC2A1, KDR
12fibrosarcoma10.0TNFSF10, CDKN1A, TKT
13cerebral hypoxia10.0CASP9, CASP3
14transitional cell carcinoma10.0CDKN1A, PTGS2, SLC2A1
15cholangiocarcinoma10.0CASP9, TNFSF10, PTGS2
16renal clear cell carcinoma10.0SLC2A1, KDR, CASP8
17bladder transitional cell carcinoma10.0SLC2A1, CASP3
18endometrial cancer10.0TNFSF10, SLC2A1, CDKN1A, CASP9
19acute leukemia10.0TKT, CASP8, TNFSF10
20hematologic cancer10.0TKT, TNFSF10, KDR
21multiple sclerosis, disease progression, modifier of10.0TNFSF10, CASP9, CASP8
22huntington disease10.0CASP3, CASP6, CASP8
23glioblastoma multiforme10.0TNFSF10, CDKN1A, KDR, CASP8
24chronic lymphocytic leukemia10.0CASP3, TNFSF10, CASP8
25nasopharyngeal carcinoma10.0TKT, CASP9, CASP3
26hiv-110.0TKT, TYMS, CASP8
27bladder cancer, somatic10.0TKT, TYMS, TNFSF10, CDKN1A
28tuberculosis10.0CASP9, TKT, TYMS, CASP8
29thyroid cancer, anaplastic10.0CASP8, TNFSF10, CASP3, CDKN1A
30mesothelioma, somatic10.0MSLN, KDR, TNFSF10, TYMS
31sarcoma10.0TKT, CASP9, KDR
32prostate cancer10.0CASP3, CASP8, TNFSF10, CDKN1A
33hyperglycemia10.0TKT, SLC2A1, CASP3
34medulloblastoma10.0CASP3, CASP8, TNFSF10, CASP9
35precursor t-cell acute lymphoblastic leukemia10.0CASP3, TNFSF10, TYMS
36small cell cancer of the lung, somatic10.0CASP8, KDR, CASP3
37lung benign neoplasm10.0TKT, CASP3, KDR
38congenital heart disease10.0CASP9, TKT, SLC2A1
39parkinson disease, late-onset10.0CASP9, CASP8, CASP3
40oral cancer10.0CASP9, CDKN1A, PTGS2, CASP3
41cowpox10.0TKT, CASP3, CASP8, TNFSF10
42thyroid cancer10.0SLC2A1, TKT, KDR, TNFSF10, CDKN1A
43leukemia, acute promyelocytic10.0CASP8, CDKN1A, CASP3, TNFSF10, CASP9
44myeloid leukemia10.0CDKN1A, TNFSF10, CASP8, CASP3, CASP9
45myeloma10.0CASP8, CASP9, CASP3, TNFSF10, CDKN1A
46leukemia, acute lymphoblastic10.0CASP3, TYMS, CASP8
47b-cell lymphomas10.0CASP3, CASP8, CDKN1A, CASP9, TKT
48astrocytoma10.0TNFSF10, KDR, CASP8, CASP9, CDKN1A, SLC2A1
49chest wall lymphoma10.0
50cervicitis10.0

Graphical network of the top 20 diseases related to Thoracic Cancer:



Diseases related to thoracic cancer

Symptoms for Thoracic Cancer

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Drugs & Therapeutics for Thoracic Cancer

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Drug clinical trials:

Search ClinicalTrials for Thoracic Cancer

Search NIH Clinical Center for Thoracic Cancer

Genetic Tests for Thoracic Cancer

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Anatomical Context for Thoracic Cancer

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MalaCards organs/tissues related to Thoracic Cancer:

33
Lung, Trachea

FMA organs/tissues related to Thoracic Cancer:

16
The thoracic cavity

Animal Models for Thoracic Cancer or affiliated genes

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MGI Mouse Phenotypes related to Thoracic Cancer:

37 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5TNFSF10, PTGS2, KDR, CASP8, CDKN1A, TKT
2MP:00053678.5PTGS2, CASP8, CASP3, CDKN1A, TKT
3MP:00053808.4PTGS2, KDR, CASP8, CASP9, CDKN1A, SLC2A1
4MP:00053698.4CDKN1A, CASP3, CASP8, KDR, PTGS2
5MP:00107718.4CDKN1A, CASP3, CASP8, KDR, PTGS2
6MP:00053888.3PTGS2, KDR, CASP8, CASP3, CASP9, CDKN1A
7MP:00053798.3PTGS2, CASP8, CASP3, CDKN1A, TKT
8MP:00053908.0TNFSF10, PTGS2, KDR, CASP3, CDKN1A
9MP:00053858.0PTGS2, KDR, CASP8, CASP3, CASP9, CDKN1A
10MP:00053978.0TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP9
11MP:00053877.9TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP9
12MP:00030127.8PTGS2, KDR, CASP3, CASP6, CDKN1A, SLC2A1
13MP:00053917.7PTGS2, KDR, CASP3, CASP6, CDKN1A, TKT
14MP:00107687.3TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP9
15MP:00053867.3PTGS2, KDR, CASP3, CASP6, CDKN1A, TKT
16MP:00053847.2PTGS2, KDR, CASP8, CASP3, CASP9, CASP6
17MP:00053767.1TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP6
18MP:00036316.9SLC2A1, PTGS2, KDR, CASP8, CASP3, CASP9
19MP:00053786.8PTGS2, KDR, CASP8, CASP3, CASP9, CASP6

Publications for Thoracic Cancer

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Articles related to Thoracic Cancer:

(show all 38)
idTitleAuthorsYear
1
Preferences for disclosure of disease related information among thoracic cancer patients. (25682317)
2015
2
New histone deacetylase inhibitors improve cisplatin antitumor properties against thoracic cancer cells. (24980825)
2014
3
Comparison of timing and decision-makers of do-not-resuscitate orders between thoracic cancer and non-cancer respiratory disease patients dying in a Japanese acute care hospital. (24414996)
2014
4
Advantages of simulating thoracic cancer patients in an upright position. (24621432)
2014
5
Predictors of smoking relapse in patients with thoracic cancer or head and neck cancer. (23280005)
2013
6
Objected constrained registration and manifold learning: a new patient setup approach in image guided radiation therapy of thoracic cancer. (23556880)
2013
7
Providing nutritional support to patients with thoracic cancer: findings of a dedicated rehabilitation service. (23452729)
2013
8
IMRT treatment plans and functional planning with functional lung imaging from 4D-CT for thoracic cancer patients. (23281734)
2013
9
Occupational therapy needs of patients with thoracic cancer at the time of diagnosis: findings of a dedicated rehabilitation service. (23269421)
2013
10
A study of respiration-correlated cone-beam CT scans to correct target positioning errors in radiotherapy of thoracic cancer. (23039621)
2012
11
Exploring physical activity level in patients with thoracic cancer: implications for use as an outcome measure. (22311375)
2012
12
Factors influencing exercise performance in thoracic cancer. (22104542)
2012
13
Role of cervical cordotomy and other neurolytic procedures in thoracic cancer pain. (20019619)
2010
14
Identifying supportive and palliative care needs in people with a recent diagnosis of thoracic cancer: acceptability of the SPARC questionnaire. (20671310)
2010
15
Emerging role of thymidylate synthase for the pharmacogenomic selection of patients with thoracic cancer. (20557852)
2010
16
Thoracic cancer surgeries. (19553762)
2009
17
Targeting HER pathway in head and neck and thoracic cancers]. (19433372)
2009
18
Functional lung imaging in thoracic cancer radiotherapy. (18376378)
2008
19
Use of a Cybex NORM dynamometer to assess muscle function in patients with thoracic cancer. (18402699)
2008
20
Other thoracic cancers. Malignant pleural mesothelioma: biology and diagnosis]. (18971844)
2008
21
Patient participation in thoracic cancer clinical trials. (18166833)
2008
22
Survival improvement in thoracic cancer: progress from the last decade and beyond. (17686443)
2007
23
Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. (17136498)
2007
24
Clinical significance of integrated PET/CT in the diagnosis of thoracic cancers]. (17763680)
2007
25
Influence of preoperative exercise capacity on length of stay after thoracic cancer surgery. (17588411)
2007
26
The essential role of the mitochondria-dependent death-signaling cascade in chemotherapy-induced potentiation of Apo2L/TRAIL cytotoxicity in cultured thoracic cancer cells: amplified caspase 8 is indispensable for combination-mediated massive cell death. (16925970)
2006
27
Valproic acid, an antiepileptic drug with histone deacetylase inhibitory activity, potentiates the cytotoxic effect of Apo2L/TRAIL on cultured thoracic cancer cells through mitochondria-dependent caspase activation. (16820090)
2006
28
Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. (17140955)
2006
29
Pemetrexed in thoracic cancer. (16634714)
2006
30
New investigative regimens and cytotoxic agents in thoracic cancers: gemcitabine and pemetrexed. (15339053)
2004
31
Gemcitabine, pemetrexed, and novel agents in the treatment of thoracic cancer. Selected presentations from the 10th World Congress on Lung Cancer. Vancouver, Canada. (15675032)
2004
32
Combination of a COX-2 inhibitor with radiotherapy or radiochemotherapy in the treatment of thoracic cancer. (12902863)
2003
33
Comparison of (11)C-choline and (18)F-FDG PET in primary diagnosis and staging of patients with thoracic cancer. (11850480)
2002
34
Technical aspects of the deep inspiration breath-hold technique in the treatment of thoracic cancer. (11072177)
2000
35
Antifungal therapy in thoracic cancer patients with low dose liposomal amphotericin B (AmBisome). (11118876)
2000
36
Balance of proinflammatory and antiinflammatory cytokines at thoracic cancer operation. (9800796)
1998
37
Thoracic cancer surgery in the elderly. (9800968)
1998
38
Photodynamic therapy for thoracic cancer: biology and applications. (7688984)
1993

Variations for Thoracic Cancer

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Expression for genes affiliated with Thoracic Cancer

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Search GEO for disease gene expression data for Thoracic Cancer.

Pathways for genes affiliated with Thoracic Cancer

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Pathways related to Thoracic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9CASP8, TNFSF10
2
Show member pathways
9.7CASP9, CASP3
3
Show member pathways
Signal transduction PTEN pathway60
9.4CDKN1A, CASP9, CASP3
49.4CASP3, CASP9, CASP8
5
Show member pathways
9.4CASP9, CASP3, CASP8
69.4CASP8, CASP9, CASP3
7
Show member pathways
9.4CASP9, CASP3, CASP8
8
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.4CASP8, CASP9, CASP3
9
Show member pathways
TRAIL signaling pathway38
9.3TNFSF10, CASP3, CASP8
109.3KDR, CASP3, CDKN1A
11
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1CASP3, CASP9, CDKN1A, CASP8
12
Show member pathways
DNA damage response38
9.1CASP9, CASP8, CASP3, CDKN1A
13
Show member pathways
9.0CASP9, TNFSF10, CASP3, CASP8
149.0CASP8, CASP3, TNFSF10, CASP9
159.0CASP6, CDKN1A, SLC2A1
169.0CASP3, PTGS2, CASP8
178.8CASP9, CASP3, CASP6
18
Show member pathways
8.8CASP9, CASP3, CASP6
198.8CASP3, CASP6, CASP9
20
Show member pathways
8.8CASP8, CASP6, CASP3
218.8CASP3, CDKN1A, PTGS2, CASP9
228.8CDKN1A, CASP9, PTGS2, CASP3
238.8CDKN1A, CASP6, PTGS2
24
Show member pathways
8.7CASP9, CASP3, PTGS2, CASP8
25
Show member pathways
8.5CASP8, CASP3, CASP9, CASP6
26
Show member pathways
8.5CASP8, CASP3, CASP9, CASP6
27
Show member pathways
MAPK signaling pathway38
8.5CASP8, CASP9, CASP6, CASP3
28
Show member pathways
8.5CASP6, CASP3, CASP8, CASP9
298.5CASP9, CASP3, CASP8, CASP6
308.5CASP9, CASP3, CASP8, CASP6
31
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
8.5CASP8, CASP6, CASP3, CASP9
32
Show member pathways
8.5CASP9, CASP8, CASP3, CASP6
33
Show member pathways
8.5CASP6, CASP9, CASP3, TNFSF10
34
Show member pathways
8.3CASP8, CASP3, CASP6, CDKN1A, CASP9
35
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.2TNFSF10, CASP8, CASP6, CASP3, CASP9
36
Show member pathways
8.2CASP9, TNFSF10, CASP8, CASP6, CASP3
37
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
8.2CASP8, TNFSF10, CASP3, CASP9, CASP6
38
Show member pathways
8.2TNFSF10, CASP8, CASP3, CASP9, CASP6
398.2CASP8, TNFSF10, CASP9, CASP6, CASP3
40
Show member pathways
8.1KDR, CASP8, CASP3, CASP9, CASP6
41
Show member pathways
8.1KDR, CASP6, CASP3, CASP8, CASP9
428.1CASP9, CASP3, CASP8, PTGS2, SLC2A1, CDKN1A
438.0TYMS, CASP9, PTGS2, CASP8, CASP3, CDKN1A
44
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
8.0CASP6, CASP8, CASP3, CDKN1A, TNFSF10, CASP9
45
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.0TNFSF10, CASP9, CASP6, CDKN1A, CASP8, CASP3
46
Show member pathways
7.9KDR, CDKN1A, CASP3, TNFSF10, CASP9, CASP6
47
Show member pathways
7.8CASP3, CASP9, CASP8, TNFSF10, KDR, CASP6
48
Show member pathways
7.5KDR, SLC2A1, CASP3, CASP9, CASP6, TNFSF10
49
Show member pathways
6.9CDKN1A, CASP6, KDR, TNFSF10, CASP9, CASP3
50
Show member pathways
6.9TNFSF10, KDR, CASP8, CASP3, CASP9, CASP6

Compounds for genes affiliated with Thoracic Cancer

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Compounds related to Thoracic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 211)
idCompoundScoreTop Affiliating Genes
1perifosine459.7TNFSF10, CASP8, CDKN1A, CASP9
2cccp459.6SLC2A1, CASP9, TNFSF10, CASP8
3vitamin e succinate459.2CASP9, TNFSF10, CDKN1A, CASP3, CASP8
4noxa459.2TNFSF10, CASP8, CASP3, CASP9, CDKN1A
5cd 437459.2TNFSF10, CASP8, CASP9, CASP3, CDKN1A
6indole-3-carbinol459.1TNFSF10, CASP9, CASP3, CASP8, CDKN1A
7depsipeptide459.1CASP9, CASP3, CASP8, TNFSF10, CDKN1A
8suberoylanilide hydroxamic acid459.0CASP8, TNFSF10, CASP3, CASP9, CDKN1A
9n-(4-hydroxyphenyl)retinamide459.0CASP3, CDKN1A, CASP8, TNFSF10, CASP9
10sulindac sulfide458.8CASP9, PTGS2, TNFSF10, CASP3, CASP8
11triptolide458.8TNFSF10, PTGS2, CASP8, CASP9, CASP3
12parthenolide45 39.8PTGS2, CASP9, CASP3, TNFSF10, CASP8
13bortezomib45 51 1310.8TNFSF10, KDR, CASP8, CASP3, CASP9, CDKN1A
14tunicamycin45 619.7CASP8, CASP9, SLC2A1, CASP3, TNFSF10
15adriamycin458.7CASP3, CASP9, CASP8, TNFSF10, TYMS, CDKN1A
16mg 13245 619.7TNFSF10, CASP9, KDR, CASP3, CASP8, CDKN1A
17z-vad-fmk45 619.6TNFSF10, CASP8, CASP6, CASP3, CASP9
18az 10417808618.6CASP6, CASP9, CASP3, CASP8
19sulforaphane458.6CASP8, CASP3, PTGS2, CASP9, CDKN1A, TNFSF10
2015-deoxy-delta-12,14-prostaglandin j2458.6CDKN1A, PTGS2, CASP9, CASP3, CASP8, TNFSF10
21z-devd-fmk61 309.6CASP8, CASP6, CASP9, CASP3
22arsenite45 269.5TNFSF10, SLC2A1, CDKN1A, CASP9, CASP3, CASP8
23docetaxel45 51 61 1311.5CASP8, CASP3, CASP9, CDKN1A, KDR, TYMS
24resveratrol45 61 26 1311.5CDKN1A, CASP9, PTGS2, TNFSF10, CASP3, CASP8
25flavopiridol45 139.5CASP9, CDKN1A, CASP3, CASP8, TNFSF10
26imatinib45 51 1310.5TKT, TNFSF10, CDKN1A, CASP3, CASP8, KDR
27z-dqmd-fmk61 309.4CASP8, CASP6, CASP9, CASP3
28troglitazone45 30 61 1311.4SLC2A1, CDKN1A, CASP3, CASP8, PTGS2, TNFSF10
29gefitinib45 51 1310.4CDKN1A, TKT, PTGS2, TNFSF10, TYMS, KDR
30butyrate458.4SLC2A1, CDKN1A, CASP9, CASP3, CASP8, TNFSF10
31curcumin458.3CASP8, CDKN1A, CASP9, CASP3, TNFSF10, PTGS2
32wortmannin458.3CASP8, KDR, CASP3, SLC2A1, TNFSF10, CASP9
33rapamycin458.3TKT, TNFSF10, KDR, CASP3, CASP9, CDKN1A
34celecoxib45 61 30 51 26 1313.2CASP9, CASP3, CASP8, KDR, PTGS2, CDKN1A
35doxorubicin45 51 1310.2TYMS, CASP8, KDR, TNFSF10, CASP3, CDKN1A
36n acetylcysteine458.1PTGS2, TNFSF10, KDR, CASP8, CASP3, CDKN1A
37pd 98,059458.1TNFSF10, PTGS2, CASP8, CASP9, SLC2A1, CDKN1A
38actinomycin d458.0TNFSF10, SLC2A1, CASP9, CASP3, CDKN1A, CASP8
395fluorouracil457.9TNFSF10, CASP8, CASP3, TKT, SLC2A1, KDR
40egcg457.8SLC2A1, CASP3, CASP8, KDR, PTGS2, TNFSF10
41ly294002457.8CDKN1A, CASP3, TNFSF10, PTGS2, KDR, CASP8
42genistein45 30 61 3 26 1312.8TKT, CASP9, CDKN1A, CASP3, KDR, PTGS2
43gemcitabine45 51 139.7CASP3, CASP8, KDR, PTGS2, CDKN1A, TNFSF10
44camptothecin45 61 139.5TNFSF10, CDKN1A, CASP6, CASP9, CASP3, CASP8
45paclitaxel45 51 139.5CASP8, CASP6, CDKN1A, TNFSF10, CASP9, CASP3
46vegf457.1CASP3, PTGS2, KDR, CDKN1A, MSLN, TNFSF10
47etoposide45 51 61 1310.0TKT, CDKN1A, CASP6, CASP9, TYMS, CASP3
48serine456.7CASP9, CASP8, KDR, TNFSF10, TYMS, CDKN1A
49cycloheximide456.6SLC2A1, TKT, TYMS, TNFSF10, PTGS2, CASP8
50cisplatin45 51 61 139.2SLC2A1, TKT, CDKN1A, CASP6, CASP9, CASP3

GO Terms for genes affiliated with Thoracic Cancer

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Cellular components related to Thoracic Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056347.2TYMS, PTGS2, KDR, CASP8, CASP3, CASP9
2cytosolGO:00058297.2TYMS, CASP8, CASP3, CASP9, CASP6, CDKN1A

Biological processes related to Thoracic Cancer according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1response to cobalt ionGO:003202510.2CASP9, CASP8
2regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:0200123910.2TNFSF10, CASP8
3positive regulation of extrinsic apoptotic signaling pathwayGO:0200123810.0CASP8, TNFSF10
4glial cell apoptotic processGO:003434910.0CASP3, CASP9
5response to antibioticGO:004667710.0CASP8, CASP9
6activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:000863510.0CASP3, CASP9
7platelet formationGO:003022010.0CASP3, CASP9
8negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:00457369.9CASP3, CDKN1A
9execution phase of apoptosisGO:00971949.9CASP3, CASP8
10phosphatidylinositol-mediated signalingGO:00480159.8CASP9, TYMS, CDKN1A
11extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.7CASP3, CASP8
12cellular response to UVGO:00346449.7CASP9, PTGS2
13cellular response to DNA damage stimulusGO:00069749.7CDKN1A, CASP3, CASP9
14apoptotic signaling pathwayGO:00971909.7TNFSF10, CASP8, CASP3
15response to estradiolGO:00323559.6CASP9, PTGS2, CASP8
16response to lipopolysaccharideGO:00324969.6PTGS2, CASP8, CASP9
17positive regulation of neuron apoptotic processGO:00435259.6CASP9, CASP3
18intrinsic apoptotic signaling pathwayGO:00971939.5CDKN1A, CASP8, CASP3, CASP9
19neurotrophin TRK receptor signaling pathwayGO:00480119.4CASP3, CDKN1A, CASP9
20response to tumor necrosis factorGO:00346129.4PTGS2, CASP8, CASP3
21response to UVGO:00094119.4CASP3, CDKN1A
22angiogenesisGO:00015259.4CASP8, PTGS2, KDR
23cellular component disassembly involved in execution phase of apoptosisGO:00069219.2CASP8, CASP3, CASP6
24response to drugGO:00424939.1TYMS, PTGS2, CDKN1A
25proteolysisGO:00065089.1CASP6, CASP8, CASP3
26positive regulation of apoptotic processGO:00430659.1PTGS2, TNFSF10, CASP3, CASP9
27apoptotic processGO:00069158.6CASP8, TNFSF10, CASP3, CASP6, CASP9

Molecular functions related to Thoracic Cancer according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.9TNFSF10, CASP8
2cysteine-type endopeptidase activity involved in apoptotic processGO:00971539.7CASP3, CASP8
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048619.6CDKN1A, CASP3
4peptidase activityGO:00082339.5CASP8, CASP3, CASP9
5cofactor bindingGO:00480379.3TKT, TYMS
6cysteine-type endopeptidase activityGO:00041978.7CASP6, CASP9, CASP3, CASP8
7protein bindingGO:00055156.7CDKN1A, TNFSF10, KDR, MSLN, CASP8, SLC2A1

Products for genes affiliated with Thoracic Cancer

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
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31KEGG
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62UMLS
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