MCID: THR012
MIFTS: 46

Thoracic Cancer malady

Cancer diseases, Respiratory diseases categories

Aliases & Classifications for Thoracic Cancer

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Sources:
8Disease Ontology, 44Novoseek, 61UMLS, 56SNOMED-CT, 39NCIt, 33MeSH
See all sources

Aliases & Descriptions for Thoracic Cancer:

Name: Thoracic Cancer 8 44
Malignant Neoplasm of Thorax 61
Thoracic Neoplasms 61
Thorax Neoplasm 8
 
Tumor of Thorax 8
Thoracic Tumor 8
Thorax Cancer 8


Classifications:



External Ids:

Disease Ontology8 DOID:5093
NCIt39 C3406
MeSH33 D013899

Summaries for Thoracic Cancer

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Disease Ontology:8 An organ system cancer located in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.

MalaCards based summary: Thoracic Cancer, also known as malignant neoplasm of thorax, is related to malignant pleural mesothelioma and lung cancer. An important gene associated with Thoracic Cancer is CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1)), and among its related pathways are Death Receptor Signalling and Activation of caspases through apoptosome-mediated cleavage. The compounds perifosine and cccp have been mentioned in the context of this disorder. Affiliated tissues include the thoracic cavity, lung and trachea, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Related Diseases for Thoracic Cancer

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Diseases in the Thoracic Cancer family:

Thoracic Benign Neoplasm

Diseases related to Thoracic Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1malignant pleural mesothelioma30.1TYMS, MSLN
2lung cancer30.0PTGS2, CDKN1A, TYMS
3endometriosis29.9CASP9, KDR, PTGS2
4mesothelioma29.8TKT, MSLN, TYMS, TNFSF10
5breast cancer28.3CDKN1A, CASP9, SLC2A1, CASP3, KDR, TYMS
6capillary hemangioma10.4SLC2A1
7myocardial infarction10.4PTGS2
8thyroid carcinoma, follicular10.3KDR, CDKN1A
9benign mesothelioma10.2TYMS, MSLN
10rectal neoplasm10.2CDKN1A, TYMS
11hemangioblastoma10.2SLC2A1, KDR
12fibrosarcoma10.1TNFSF10, CDKN1A, TKT
13cerebral hypoxia10.1CASP9, CASP3
14transitional cell carcinoma10.1CDKN1A, PTGS2, SLC2A1
15cholangiocarcinoma10.1CASP9, TNFSF10, PTGS2
16renal clear cell carcinoma10.1SLC2A1, KDR, CASP8
17bladder transitional cell carcinoma10.0SLC2A1, CASP3
18endometrial cancer10.0TNFSF10, SLC2A1, CDKN1A, CASP9
19acute leukemia10.0TKT, CASP8, TNFSF10
20hematologic cancer10.0TKT, TNFSF10, KDR
21multiple sclerosis, disease progression, modifier of10.0TNFSF10, CASP9, CASP8
22huntington disease10.0CASP3, CASP6, CASP8
23glioblastoma multiforme10.0TNFSF10, CDKN1A, KDR, CASP8
24chest wall lymphoma10.0
25cervicitis10.0
26mediastinal cancer10.0
27pleurisy9.9
28acute adrenal insufficiency9.9
29chronic lymphocytic leukemia9.9CASP3, TNFSF10, CASP8
30nasopharyngeal carcinoma9.9TKT, CASP9, CASP3
31hiv-19.9TKT, TYMS, CASP8
32bladder cancer, somatic9.9TKT, TYMS, TNFSF10, CDKN1A
33tuberculosis9.9CASP9, TKT, TYMS, CASP8
34thyroid cancer, anaplastic9.9CASP8, TNFSF10, CASP3, CDKN1A
35mesothelioma, somatic9.9MSLN, KDR, TNFSF10, TYMS
36sarcoma9.8TKT, CASP9, KDR
37prostate cancer9.8CASP3, CASP8, TNFSF10, CDKN1A
38hyperglycemia9.8TKT, SLC2A1, CASP3
39medulloblastoma9.8CASP3, CASP8, TNFSF10, CASP9
40precursor t-cell acute lymphoblastic leukemia9.8CASP3, TNFSF10, TYMS
41small cell cancer of the lung, somatic9.8CASP8, KDR, CASP3
42lung benign neoplasm9.8TKT, CASP3, KDR
43congenital heart disease9.8CASP9, TKT, SLC2A1
44parkinson disease, late-onset9.8CASP9, CASP8, CASP3
45oral cancer9.8CASP9, CDKN1A, PTGS2, CASP3
46cowpox9.8TKT, CASP3, CASP8, TNFSF10
47thyroid cancer9.8SLC2A1, TKT, KDR, TNFSF10, CDKN1A
48leukemia, acute promyelocytic9.7CASP8, CDKN1A, CASP3, TNFSF10, CASP9
49myeloid leukemia9.7CDKN1A, TNFSF10, CASP8, CASP3, CASP9
50myeloma9.7CASP8, CASP9, CASP3, TNFSF10, CDKN1A

Graphical network of the top 20 diseases related to Thoracic Cancer:



Diseases related to thoracic cancer

Symptoms for Thoracic Cancer

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Drugs & Therapeutics for Thoracic Cancer

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Drug clinical trials:

Search ClinicalTrials for Thoracic Cancer

Search NIH Clinical Center for Thoracic Cancer

Genetic Tests for Thoracic Cancer

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Anatomical Context for Thoracic Cancer

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MalaCards organs/tissues related to Thoracic Cancer:

31
Lung, Trachea

FMA organs/tissues related to Thoracic Cancer:

14
The thoracic cavity

Animal Models for Thoracic Cancer or affiliated genes

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MGI Mouse Phenotypes related to Thoracic Cancer:

35 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5TKT, CASP8, CDKN1A, PTGS2, KDR, TNFSF10
2MP:00053678.5CASP8, PTGS2, CASP3, CDKN1A, TKT
3MP:00053808.4SLC2A1, CASP8, KDR, PTGS2, CASP9, CDKN1A
4MP:00053698.4CASP8, CDKN1A, PTGS2, CASP3, KDR
5MP:00107718.4PTGS2, CDKN1A, CASP8, KDR, CASP3
6MP:00053888.3CASP8, KDR, CASP3, CDKN1A, CASP9, PTGS2
7MP:00053798.3CASP8, PTGS2, CDKN1A, TKT, CASP3
8MP:00053908.0TNFSF10, PTGS2, KDR, CASP3, CDKN1A
9MP:00053858.0TKT, CASP9, CASP3, PTGS2, CASP8, KDR
10MP:00053978.0TNFSF10, PTGS2, KDR, CASP3, CDKN1A, CASP9
11MP:00053877.9CDKN1A, CASP9, CASP3, CASP8, PTGS2, KDR
12MP:00030127.8CASP3, CASP6, CDKN1A, SLC2A1, KDR, PTGS2
13MP:00053917.7CDKN1A, KDR, TKT, CASP6, CASP3, PTGS2
14MP:00107687.3CASP3, CDKN1A, TNFSF10, PTGS2, KDR, CASP8
15MP:00053867.3PTGS2, SLC2A1, TKT, CDKN1A, CASP6, KDR
16MP:00053847.2CASP8, CASP9, PTGS2, KDR, CASP3, SLC2A1
17MP:00053767.1CASP6, CASP3, CDKN1A, KDR, PTGS2, TNFSF10
18MP:00036316.9TKT, KDR, CASP8, PTGS2, CASP3, SLC2A1
19MP:00053786.8KDR, CASP8, SLC2A1, TKT, CDKN1A, CASP6

Publications for Thoracic Cancer

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Articles related to Thoracic Cancer:

(show all 38)
idTitleAuthorsYear
1
Preferences for disclosure of disease related information among thoracic cancer patients. (25682317)
2015
2
New histone deacetylase inhibitors improve cisplatin antitumor properties against thoracic cancer cells. (24980825)
2014
3
Comparison of timing and decision-makers of do-not-resuscitate orders between thoracic cancer and non-cancer respiratory disease patients dying in a Japanese acute care hospital. (24414996)
2014
4
Advantages of simulating thoracic cancer patients in an upright position. (24621432)
2014
5
Predictors of smoking relapse in patients with thoracic cancer or head and neck cancer. (23280005)
2013
6
Objected constrained registration and manifold learning: a new patient setup approach in image guided radiation therapy of thoracic cancer. (23556880)
2013
7
Providing nutritional support to patients with thoracic cancer: findings of a dedicated rehabilitation service. (23452729)
2013
8
IMRT treatment plans and functional planning with functional lung imaging from 4D-CT for thoracic cancer patients. (23281734)
2013
9
Occupational therapy needs of patients with thoracic cancer at the time of diagnosis: findings of a dedicated rehabilitation service. (23269421)
2013
10
A study of respiration-correlated cone-beam CT scans to correct target positioning errors in radiotherapy of thoracic cancer. (23039621)
2012
11
Exploring physical activity level in patients with thoracic cancer: implications for use as an outcome measure. (22311375)
2012
12
Factors influencing exercise performance in thoracic cancer. (22104542)
2012
13
Role of cervical cordotomy and other neurolytic procedures in thoracic cancer pain. (20019619)
2010
14
Identifying supportive and palliative care needs in people with a recent diagnosis of thoracic cancer: acceptability of the SPARC questionnaire. (20671310)
2010
15
Emerging role of thymidylate synthase for the pharmacogenomic selection of patients with thoracic cancer. (20557852)
2010
16
Thoracic cancer surgeries. (19553762)
2009
17
Targeting HER pathway in head and neck and thoracic cancers]. (19433372)
2009
18
Functional lung imaging in thoracic cancer radiotherapy. (18376378)
2008
19
Use of a Cybex NORM dynamometer to assess muscle function in patients with thoracic cancer. (18402699)
2008
20
Other thoracic cancers. Malignant pleural mesothelioma: biology and diagnosis]. (18971844)
2008
21
Patient participation in thoracic cancer clinical trials. (18166833)
2008
22
Survival improvement in thoracic cancer: progress from the last decade and beyond. (17686443)
2007
23
Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. (17136498)
2007
24
Clinical significance of integrated PET/CT in the diagnosis of thoracic cancers]. (17763680)
2007
25
Influence of preoperative exercise capacity on length of stay after thoracic cancer surgery. (17588411)
2007
26
The essential role of the mitochondria-dependent death-signaling cascade in chemotherapy-induced potentiation of Apo2L/TRAIL cytotoxicity in cultured thoracic cancer cells: amplified caspase 8 is indispensable for combination-mediated massive cell death. (16925970)
2006
27
Valproic acid, an antiepileptic drug with histone deacetylase inhibitory activity, potentiates the cytotoxic effect of Apo2L/TRAIL on cultured thoracic cancer cells through mitochondria-dependent caspase activation. (16820090)
2006
28
Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. (17140955)
2006
29
Pemetrexed in thoracic cancer. (16634714)
2006
30
New investigative regimens and cytotoxic agents in thoracic cancers: gemcitabine and pemetrexed. (15339053)
2004
31
Gemcitabine, pemetrexed, and novel agents in the treatment of thoracic cancer. Selected presentations from the 10th World Congress on Lung Cancer. Vancouver, Canada. (15675032)
2004
32
Combination of a COX-2 inhibitor with radiotherapy or radiochemotherapy in the treatment of thoracic cancer. (12902863)
2003
33
Comparison of (11)C-choline and (18)F-FDG PET in primary diagnosis and staging of patients with thoracic cancer. (11850480)
2002
34
Technical aspects of the deep inspiration breath-hold technique in the treatment of thoracic cancer. (11072177)
2000
35
Antifungal therapy in thoracic cancer patients with low dose liposomal amphotericin B (AmBisome). (11118876)
2000
36
Balance of proinflammatory and antiinflammatory cytokines at thoracic cancer operation. (9800796)
1998
37
Thoracic cancer surgery in the elderly. (9800968)
1998
38
Photodynamic therapy for thoracic cancer: biology and applications. (7688984)
1993

Variations for Thoracic Cancer

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Expression for genes affiliated with Thoracic Cancer

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Search GEO for disease gene expression data for Thoracic Cancer.

Pathways for genes affiliated with Thoracic Cancer

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Pathways related to Thoracic Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9CASP8, TNFSF10
2
Show member pathways
9.7CASP9, CASP3
3
Show member pathways
Signal transduction PTEN pathway59
9.4CDKN1A, CASP9, CASP3
49.4CASP3, CASP9, CASP8
5
Show member pathways
9.4CASP9, CASP3, CASP8
69.4CASP8, CASP9, CASP3
7
Show member pathways
9.4CASP9, CASP3, CASP8
8
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.4CASP8, CASP9, CASP3
9
Show member pathways
TRAIL signaling pathway36
9.3TNFSF10, CASP3, CASP8
109.3KDR, CASP3, CDKN1A
11
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.1CASP3, CASP9, CDKN1A, CASP8
12
Show member pathways
DNA damage response36
9.1CASP9, CASP8, CASP3, CDKN1A
13
Show member pathways
9.0CASP9, TNFSF10, CASP3, CASP8
149.0CASP8, CASP3, TNFSF10, CASP9
159.0CASP3, PTGS2, CASP8
168.8CASP9, CASP3, CASP6
17
Show member pathways
8.8CASP9, CASP3, CASP6
188.8CASP3, CASP6, CASP9
19
Show member pathways
8.8CASP8, CASP6, CASP3
208.8CASP3, CDKN1A, PTGS2, CASP9
218.8CDKN1A, CASP9, PTGS2, CASP3
228.8CDKN1A, CASP6, PTGS2
23
Show member pathways
8.7CASP9, CASP3, PTGS2, CASP8
24
Show member pathways
8.5CASP8, CASP3, CASP9, CASP6
25
Show member pathways
8.5CASP8, CASP3, CASP9, CASP6
26
Show member pathways
MAPK signaling pathway36
8.5CASP8, CASP9, CASP6, CASP3
27
Show member pathways
8.5CASP6, CASP3, CASP8, CASP9
288.5CASP9, CASP3, CASP8, CASP6
298.5CASP9, CASP3, CASP8, CASP6
30
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades59
Caspase cascade in apoptosis36
8.5CASP8, CASP6, CASP3, CASP9
31
Show member pathways
8.5CASP9, CASP8, CASP3, CASP6
32
Show member pathways
8.5CASP6, CASP9, CASP3, TNFSF10
33
Show member pathways
8.3CASP8, CASP3, CASP6, CDKN1A, CASP9
34
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
8.2TNFSF10, CASP8, CASP6, CASP3, CASP9
35
Show member pathways
8.2CASP9, TNFSF10, CASP8, CASP6, CASP3
36
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.2CASP8, TNFSF10, CASP3, CASP9, CASP6
37
Show member pathways
8.2TNFSF10, CASP8, CASP3, CASP9, CASP6
388.2CASP8, TNFSF10, CASP9, CASP6, CASP3
39
Show member pathways
8.1KDR, CASP8, CASP3, CASP9, CASP6
40
Show member pathways
8.1KDR, CASP6, CASP3, CASP8, CASP9
418.1CASP9, CASP3, CASP8, PTGS2, SLC2A1, CDKN1A
428.0TYMS, CASP9, PTGS2, CASP8, CASP3, CDKN1A
43
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways59
8.0CASP6, CASP8, CASP3, CDKN1A, TNFSF10, CASP9
44
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I59
8.0TNFSF10, CASP9, CASP6, CDKN1A, CASP8, CASP3
45
Show member pathways
7.9KDR, CDKN1A, CASP3, TNFSF10, CASP9, CASP6
46
Show member pathways
7.8CASP3, CASP9, CASP8, TNFSF10, KDR, CASP6
47
Show member pathways
7.5KDR, SLC2A1, CASP3, CASP9, CASP6, TNFSF10
48
Show member pathways
6.9CDKN1A, CASP6, KDR, TNFSF10, CASP9, CASP3
49
Show member pathways
6.9TNFSF10, KDR, CASP8, CASP3, CASP9, CASP6

Compounds for genes affiliated with Thoracic Cancer

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Compounds related to Thoracic Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 211)
idCompoundScoreTop Affiliating Genes
1perifosine449.7TNFSF10, CASP8, CDKN1A, CASP9
2cccp449.6SLC2A1, CASP9, TNFSF10, CASP8
3vitamin e succinate449.2CASP9, TNFSF10, CDKN1A, CASP3, CASP8
4noxa449.2TNFSF10, CASP8, CASP3, CASP9, CDKN1A
5cd 437449.2TNFSF10, CASP8, CASP9, CASP3, CDKN1A
6indole-3-carbinol449.1TNFSF10, CASP9, CASP3, CASP8, CDKN1A
7depsipeptide449.1CASP9, CASP3, CASP8, TNFSF10, CDKN1A
8suberoylanilide hydroxamic acid449.0CASP8, TNFSF10, CASP3, CASP9, CDKN1A
9n-(4-hydroxyphenyl)retinamide449.0CASP3, CDKN1A, CASP8, TNFSF10, CASP9
10sulindac sulfide448.8CASP9, PTGS2, TNFSF10, CASP3, CASP8
11triptolide448.8TNFSF10, PTGS2, CASP8, CASP9, CASP3
12parthenolide44 19.8PTGS2, CASP9, CASP3, TNFSF10, CASP8
13bortezomib44 50 1110.8TNFSF10, KDR, CASP8, CASP3, CASP9, CDKN1A
14tunicamycin44 609.7CASP8, CASP9, SLC2A1, CASP3, TNFSF10
15adriamycin448.7CASP3, CASP9, CASP8, TNFSF10, TYMS, CDKN1A
16mg 13244 609.7TNFSF10, CASP9, KDR, CASP3, CASP8, CDKN1A
17z-vad-fmk44 609.6TNFSF10, CASP8, CASP6, CASP3, CASP9
18az 10417808608.6CASP6, CASP9, CASP3, CASP8
19sulforaphane448.6CASP8, CASP3, PTGS2, CASP9, CDKN1A, TNFSF10
2015-deoxy-delta-12,14-prostaglandin j2448.6CDKN1A, PTGS2, CASP9, CASP3, CASP8, TNFSF10
21z-devd-fmk60 289.6CASP8, CASP6, CASP9, CASP3
22arsenite44 249.5TNFSF10, SLC2A1, CDKN1A, CASP9, CASP3, CASP8
23docetaxel44 50 60 1111.5CASP8, CASP3, CASP9, CDKN1A, KDR, TYMS
24resveratrol44 60 24 1111.5CDKN1A, CASP9, PTGS2, TNFSF10, CASP3, CASP8
25flavopiridol44 119.5CASP9, CDKN1A, CASP3, CASP8, TNFSF10
26imatinib44 50 1110.5TKT, TNFSF10, CDKN1A, CASP3, CASP8, KDR
27z-dqmd-fmk60 289.4CASP8, CASP6, CASP9, CASP3
28troglitazone44 28 60 1111.4SLC2A1, CDKN1A, CASP3, CASP8, PTGS2, TNFSF10
29gefitinib44 50 1110.4CDKN1A, TKT, PTGS2, TNFSF10, TYMS, KDR
30butyrate448.4SLC2A1, CDKN1A, CASP9, CASP3, CASP8, TNFSF10
31curcumin448.3CASP8, CDKN1A, CASP9, CASP3, TNFSF10, PTGS2
32wortmannin448.3CASP8, KDR, CASP3, SLC2A1, TNFSF10, CASP9
33rapamycin448.3TKT, TNFSF10, KDR, CASP3, CASP9, CDKN1A
34celecoxib44 60 28 50 24 1113.2CASP9, CASP3, CASP8, KDR, PTGS2, CDKN1A
35doxorubicin44 50 1110.2TYMS, CASP8, KDR, TNFSF10, CASP3, CDKN1A
36n acetylcysteine448.1PTGS2, TNFSF10, KDR, CASP8, CASP3, CDKN1A
37pd 98,059448.1TNFSF10, PTGS2, CASP8, CASP9, SLC2A1, CDKN1A
38actinomycin d448.0TNFSF10, SLC2A1, CASP9, CASP3, CDKN1A, CASP8
395fluorouracil447.9TNFSF10, CASP8, CASP3, TKT, SLC2A1, KDR
40egcg447.8SLC2A1, CASP3, CASP8, KDR, PTGS2, TNFSF10
41ly294002447.8CDKN1A, CASP3, TNFSF10, PTGS2, KDR, CASP8
42genistein44 28 60 1 24 1112.8TKT, CASP9, CDKN1A, CASP3, KDR, PTGS2
43gemcitabine44 50 119.7CASP3, CASP8, KDR, PTGS2, CDKN1A, TNFSF10
44camptothecin44 60 119.5TNFSF10, CDKN1A, CASP6, CASP9, CASP3, CASP8
45paclitaxel44 50 119.5CASP8, CASP6, CDKN1A, TNFSF10, CASP9, CASP3
46vegf447.1CASP3, PTGS2, KDR, CDKN1A, MSLN, TNFSF10
47etoposide44 50 60 1110.0TKT, CDKN1A, CASP6, CASP9, TYMS, CASP3
48serine446.7CASP9, CASP8, KDR, TNFSF10, TYMS, CDKN1A
49cycloheximide446.6SLC2A1, TKT, TYMS, TNFSF10, PTGS2, CASP8
50cisplatin44 50 60 119.2SLC2A1, TKT, CDKN1A, CASP6, CASP9, CASP3

GO Terms for genes affiliated with Thoracic Cancer

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Cellular components related to Thoracic Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056347.2PTGS2, KDR, CASP8, CASP3, CASP9, CDKN1A
2cytosolGO:00058297.2TKT, TYMS, CASP8, CASP3, CASP9, CASP6

Biological processes related to Thoracic Cancer according to GeneCards Suite gene sharing:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1response to cobalt ionGO:003202510.2CASP9, CASP8
2regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:0200123910.2TNFSF10, CASP8
3positive regulation of extrinsic apoptotic signaling pathwayGO:0200123810.0CASP8, TNFSF10
4glial cell apoptotic processGO:003434910.0CASP3, CASP9
5response to antibioticGO:004667710.0CASP8, CASP9
6activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:000863510.0CASP3, CASP9
7platelet formationGO:003022010.0CASP3, CASP9
8negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:00457369.9CASP3, CDKN1A
9execution phase of apoptosisGO:00971949.9CASP3, CASP8
10phosphatidylinositol-mediated signalingGO:00480159.8CASP9, TYMS, CDKN1A
11extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.7CASP3, CASP8
12cellular response to UVGO:00346449.7CASP9, PTGS2
13cellular response to DNA damage stimulusGO:00069749.7CDKN1A, CASP3, CASP9
14apoptotic signaling pathwayGO:00971909.7TNFSF10, CASP8, CASP3
15response to estradiolGO:00323559.6CASP9, PTGS2, CASP8
16response to lipopolysaccharideGO:00324969.6PTGS2, CASP8, CASP9
17positive regulation of neuron apoptotic processGO:00435259.6CASP9, CASP3
18intrinsic apoptotic signaling pathwayGO:00971939.5CDKN1A, CASP8, CASP3, CASP9
19neurotrophin TRK receptor signaling pathwayGO:00480119.4CASP3, CDKN1A, CASP9
20response to tumor necrosis factorGO:00346129.4PTGS2, CASP8, CASP3
21response to UVGO:00094119.4CASP3, CDKN1A
22angiogenesisGO:00015259.4CASP8, PTGS2, KDR
23cellular component disassembly involved in execution phase of apoptosisGO:00069219.2CASP8, CASP3, CASP6
24response to drugGO:00424939.1TYMS, PTGS2, CDKN1A
25proteolysisGO:00065089.1CASP6, CASP8, CASP3
26positive regulation of apoptotic processGO:00430659.1PTGS2, TNFSF10, CASP3, CASP9
27apoptotic processGO:00069158.6CASP8, TNFSF10, CASP3, CASP6, CASP9

Molecular functions related to Thoracic Cancer according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.9CASP8, TNFSF10
2cysteine-type endopeptidase activity involved in apoptotic processGO:00971539.7CASP3, CASP8
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048619.6CASP3, CDKN1A
4peptidase activityGO:00082339.5CASP8, CASP3, CASP9
5cofactor bindingGO:00480379.3TKT, TYMS
6cysteine-type endopeptidase activityGO:00041978.7CASP6, CASP9, CASP3, CASP8
7protein bindingGO:00055156.7TNFSF10, KDR, MSLN, CASP8, CASP3, CASP9

Sources for Thoracic Cancer

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet