MCID: THR012
MIFTS: 55

Thoracic Cancer malady

Cancer diseases, Respiratory diseases categories

Summaries for Thoracic Cancer

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 An organ system cancer located in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.

MalaCards: Thoracic Cancer, also known as malignant neoplasm of thorax, is related to malignant pleural mesothelioma and endometriosis. An important gene associated with Thoracic Cancer is CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1)), and among its related pathways are Death Receptor Signalling and Activation of caspases through apoptosome-mediated cleavage. The compounds perifosine and cccp have been mentioned in the context of this disorder. Affiliated tissues include the thoracic cavity, lung and trachea, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Thoracic Cancer

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Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

thoracic cancer 9 46
malignant neoplasm of thorax 63
malignant neoplasms 63
thoracic neoplasms 63
tumor of thorax 9
thorax neoplasm 9
thoracic tumor 9
thorax cancer 9


External Ids:

Disease Ontology9 DOID:5093
MeSH36 D013899
NCIt41 C3406

Related Diseases for Thoracic Cancer

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Thoracic Cancer family:

Thoracic Benign Neoplasm

Diseases related to Thoracic Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1malignant pleural mesothelioma29.9MSLN, TYMS
2endometriosis29.9CASP9, KDR, PTGS2
3lung cancer29.9CDKN1A, PTGS2, TYMS
4malignant mesothelioma29.9MSLN, KDR, TNFSF10, TYMS
5breast cancer29.5TYMS, TNFSF10, KDR, MSLN, CASP8, CASP3
6capillary hemangioma10.1SLC2A1
7myocardial infarction10.1PTGS2
8follicular thyroid carcinoma10.1CDKN1A, KDR
9benign mesothelioma10.0MSLN, TYMS
10rectal neoplasm10.0TYMS, CDKN1A
11hemangioblastoma10.0KDR, SLC2A1
12fibrosarcoma10.0TNFSF10, CDKN1A, TKT
13cerebral hypoxia10.0CASP3, CASP9
14transitional cell carcinoma10.0PTGS2, CDKN1A, SLC2A1
15cholangiocarcinoma10.0TNFSF10, PTGS2, CASP9
16renal clear cell carcinoma10.0KDR, CASP8, SLC2A1
17bladder transitional cell carcinoma10.0SLC2A1, CASP3
18endometrial carcinoma10.0SLC2A1, CDKN1A, CASP9, TNFSF10
19acute leukemia10.0TNFSF10, CASP8, TKT
20hematologic cancer10.0TKT, KDR, TNFSF10
21multiple sclerosis10.0CASP9, CASP8, TNFSF10
22huntington's disease10.0CASP6, CASP3, CASP8
23glioblastoma multiforme10.0CDKN1A, CASP8, KDR, TNFSF10
24b-cell chronic lymphocytic leukemia10.0TNFSF10, CASP8, CASP3
25nasopharynx carcinoma10.0CASP3, CASP9, TKT
26immunodeficiency with hyper igm type 210.0TKT, CASP8, TYMS
27bladder carcinoma10.0TKT, CDKN1A, TNFSF10, TYMS
28tuberculosis10.0TYMS, CASP8, CASP9, TKT
29thyroid cancer, anaplastic10.0CDKN1A, CASP3, CASP8, TNFSF10
30sarcoma10.0KDR, CASP9, TKT
31prostate cancer10.0CDKN1A, CASP3, CASP8, TNFSF10
32hyperglycemia10.0SLC2A1, TKT, CASP3
33medulloblastoma10.0CASP9, CASP3, CASP8, TNFSF10
34precursor t-cell acute lymphoblastic leukemia10.0TYMS, TNFSF10, CASP3
35lung small cell carcinoma10.0CASP3, CASP8, KDR
36lung benign neoplasm10.0TKT, CASP3, KDR
37congenital heart disease10.0SLC2A1, TKT, CASP9
38parkinson's disease10.0CASP9, CASP3, CASP8
39oral cancer10.0CDKN1A, CASP9, CASP3, PTGS2
40cowpox10.0TNFSF10, CASP8, CASP3, TKT
41thyroid cancer9.9TNFSF10, KDR, CDKN1A, TKT, SLC2A1
42chronic lymphocytic leukemia9.9TNFSF10, CASP8, CASP3, TKT
43acute promyelocytic leukemia9.9TNFSF10, CASP8, CASP3, CASP9, CDKN1A
44acute lymphocytic leukemia9.9TYMS, CASP8, CASP3
45noonan syndrome9.9
46pleurisy9.9
47acute adrenal insufficiency9.9
48myeloid leukemia9.9TNFSF10, CASP8, CASP3, CASP9, CDKN1A
49myeloma9.9CDKN1A, CASP9, CASP3, CASP8, TNFSF10
50b-cell lymphomas9.9CASP8, CASP3, CASP9, CDKN1A, TKT

Graphical network of the top 20 diseases related to Thoracic Cancer:



Diseases related to thoracic cancer

Symptoms for Thoracic Cancer

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Drugs & Therapeutics for Thoracic Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Thoracic Cancer

Drug clinical trials:

Search ClinicalTrials for Thoracic Cancer

Search NIH Clinical Center for Thoracic Cancer

Search CenterWatch for Thoracic Cancer

Genetic Tests for Thoracic Cancer

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Anatomical Context for Thoracic Cancer

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Sources:
34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Thoracic Cancer:

34
Lung, Trachea

FMA organs/tissues related to Thoracic Cancer:

15
The thoracic cavity

Animal Models for Thoracic Cancer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Thoracic Cancer:

38 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5TNFSF10, PTGS2, KDR, CASP8, CDKN1A, TKT
2MP:00053678.5PTGS2, CASP8, CASP3, CDKN1A, TKT
3MP:00053808.4PTGS2, KDR, CASP8, CASP9, CDKN1A, SLC2A1
4MP:00053698.4CDKN1A, CASP3, CASP8, KDR, PTGS2
5MP:00107718.4CDKN1A, CASP3, CASP8, KDR, PTGS2
6MP:00053888.3PTGS2, KDR, CASP8, CASP3, CASP9, CDKN1A
7MP:00053798.3PTGS2, CASP8, CASP3, CDKN1A, TKT
8MP:00053908.0TNFSF10, PTGS2, KDR, CASP3, CDKN1A
9MP:00053858.0PTGS2, KDR, CASP8, CASP3, CASP9, CDKN1A
10MP:00053978.0TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP9
11MP:00053877.9TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP9
12MP:00030127.8PTGS2, KDR, CASP3, CASP6, CDKN1A, SLC2A1
13MP:00053917.7PTGS2, KDR, CASP3, CASP6, CDKN1A, TKT
14MP:00107687.3TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP9
15MP:00053867.3PTGS2, KDR, CASP3, CASP6, CDKN1A, TKT
16MP:00053847.2PTGS2, KDR, CASP8, CASP3, CASP9, CASP6
17MP:00053767.1TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP6
18MP:00036316.9SLC2A1, PTGS2, KDR, CASP8, CASP3, CASP9
19MP:00053786.8PTGS2, KDR, CASP8, CASP3, CASP9, CASP6

Publications for Thoracic Cancer

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53PubMed
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Articles related to Thoracic Cancer:

(show all 36)
idTitleAuthorsYear
1
Comparison of timing and decision-makers of do-not-resuscitate orders between thoracic cancer and non-cancer respiratory disease patients dying in a Japanese acute care hospital. (24414996)
2014
2
Predictors of smoking relapse in patients with thoracic cancer or head and neck cancer. (23280005)
2013
3
Objected constrained registration and manifold learning: a new patient setup approach in image guided radiation therapy of thoracic cancer. (23556880)
2013
4
Providing nutritional support to patients with thoracic cancer: findings of a dedicated rehabilitation service. (23452729)
2013
5
IMRT treatment plans and functional planning with functional lung imaging from 4D-CT for thoracic cancer patients. (23281734)
2013
6
Occupational therapy needs of patients with thoracic cancer at the time of diagnosis: findings of a dedicated rehabilitation service. (23269421)
2013
7
When will I get my breath back? Recovery time of exercise-induced breathlessness in patients with thoracic cancer. (22285531)
2012
8
A study of respiration-correlated cone-beam CT scans to correct target positioning errors in radiotherapy of thoracic cancer. (23039621)
2012
9
Exploring physical activity level in patients with thoracic cancer: implications for use as an outcome measure. (22311375)
2012
10
Factors influencing exercise performance in thoracic cancer. (22104542)
2012
11
Role of cervical cordotomy and other neurolytic procedures in thoracic cancer pain. (20019619)
2010
12
Identifying supportive and palliative care needs in people with a recent diagnosis of thoracic cancer: acceptability of the SPARC questionnaire. (20671310)
2010
13
Emerging role of thymidylate synthase for the pharmacogenomic selection of patients with thoracic cancer. (20557852)
2010
14
Thoracic cancer surgeries. (19553762)
2009
15
Targeting HER pathway in head and neck and thoracic cancers]. (19433372)
2009
16
Functional lung imaging in thoracic cancer radiotherapy. (18376378)
2008
17
Use of a Cybex NORM dynamometer to assess muscle function in patients with thoracic cancer. (18402699)
2008
18
Other thoracic cancers. Malignant pleural mesothelioma: biology and diagnosis]. (18971844)
2008
19
Patient participation in thoracic cancer clinical trials. (18166833)
2008
20
Survival improvement in thoracic cancer: progress from the last decade and beyond. (17686443)
2007
21
Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. (17136498)
2007
22
Clinical significance of integrated PET/CT in the diagnosis of thoracic cancers]. (17763680)
2007
23
Influence of preoperative exercise capacity on length of stay after thoracic cancer surgery. (17588411)
2007
24
The essential role of the mitochondria-dependent death-signaling cascade in chemotherapy-induced potentiation of Apo2L/TRAIL cytotoxicity in cultured thoracic cancer cells: amplified caspase 8 is indispensable for combination-mediated massive cell death. (16925970)
2006
25
Valproic acid, an antiepileptic drug with histone deacetylase inhibitory activity, potentiates the cytotoxic effect of Apo2L/TRAIL on cultured thoracic cancer cells through mitochondria-dependent caspase activation. (16820090)
2006
26
Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. (17140955)
2006
27
Pemetrexed in thoracic cancer. (16634714)
2006
28
New investigative regimens and cytotoxic agents in thoracic cancers: gemcitabine and pemetrexed. (15339053)
2004
29
Gemcitabine, pemetrexed, and novel agents in the treatment of thoracic cancer. Selected presentations from the 10th World Congress on Lung Cancer. Vancouver, Canada. (15675032)
2004
30
Combination of a COX-2 inhibitor with radiotherapy or radiochemotherapy in the treatment of thoracic cancer. (12902863)
2003
31
Comparison of (11)C-choline and (18)F-FDG PET in primary diagnosis and staging of patients with thoracic cancer. (11850480)
2002
32
Technical aspects of the deep inspiration breath-hold technique in the treatment of thoracic cancer. (11072177)
2000
33
Antifungal therapy in thoracic cancer patients with low dose liposomal amphotericin B (AmBisome). (11118876)
2000
34
Balance of proinflammatory and antiinflammatory cytokines at thoracic cancer operation. (9800796)
1998
35
Thoracic cancer surgery in the elderly. (9800968)
1998
36
Photodynamic therapy for thoracic cancer: biology and applications. (7688984)
1993

Variations for Thoracic Cancer

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Expression for genes affiliated with Thoracic Cancer

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thoracic Cancer

Search GEO for disease gene expression data for Thoracic Cancer.

Pathways for genes affiliated with Thoracic Cancer

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Sources:
51PathCards, 56Reactome, 31KEGG, 61Thomson Reuters, 54QIAGEN, 39NCBI BioSystems Database, 55R&D Systems, 13EMD Millipore, 58SinoBiological, 52PharmGKB, 5Cell Signaling Technology, 62Tocris Bioscience
See all sources

Pathways related to Thoracic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9CASP8, TNFSF10
2
Show member pathways
9.7CASP9, CASP3
3
Show member pathways
Signal transduction PTEN pathway61
9.4CDKN1A, CASP9, CASP3
4
Show member pathways
9.4CASP8, CASP3, CASP9
59.4CASP8, CASP3, CASP9
69.4CASP9, CASP3, CASP8
7
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.4CASP9, CASP3, CASP8
8
Show member pathways
9.4CASP9, CASP3, CASP8
9
Show member pathways
TRAIL signaling pathway39
9.3CASP3, CASP8, TNFSF10
109.3CDKN1A, CASP3, KDR
11
Show member pathways
DNA damage response39
9.1CASP8, CASP3, CASP9, CDKN1A
12
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.1CASP8, CASP3, CASP9, CDKN1A
13
Show member pathways
9.0TNFSF10, CASP8, CASP3, CASP9
149.0CASP9, CASP3, CASP8, TNFSF10
159.0SLC2A1, CDKN1A, CASP6
169.0PTGS2, CASP8, CASP3
17
Show member pathways
8.8CASP6, CASP9, CASP3
188.8CASP6, CASP9, CASP3
198.8CASP3, CASP9, CASP6
20
Show member pathways
8.8CASP8, CASP3, CASP6
218.8PTGS2, CASP3, CASP9, CDKN1A
228.8PTGS2, CASP3, CASP9, CDKN1A
238.8PTGS2, CASP6, CDKN1A
24
Show member pathways
8.7CASP9, CASP3, CASP8, PTGS2
25
Show member pathways
8.5CASP8, CASP3, CASP9, CASP6
26
Show member pathways
MAPK signaling pathway39
8.5CASP8, CASP3, CASP9, CASP6
27
Show member pathways
8.5CASP8, CASP3, CASP9, CASP6
288.5CASP6, CASP9, CASP3, CASP8
298.5CASP6, CASP9, CASP3, CASP8
30
Show member pathways
FAS pathway and Stress induction of HSP regulation39
Apoptosis and survival FAS signaling cascades61
Caspase cascade in apoptosis39
8.5CASP6, CASP9, CASP3, CASP8
31
Show member pathways
8.5CASP8, CASP3, CASP9, CASP6
32
Show member pathways
8.5CASP8, CASP3, CASP9, CASP6
33
Show member pathways
8.5TNFSF10, CASP3, CASP9, CASP6
34
Show member pathways
8.3CASP8, CASP3, CASP9, CASP6, CDKN1A
35
Show member pathways
8.2TNFSF10, CASP8, CASP3, CASP9, CASP6
36
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
8.2TNFSF10, CASP8, CASP3, CASP9, CASP6
37
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
8.2TNFSF10, CASP8, CASP3, CASP9, CASP6
388.2TNFSF10, CASP8, CASP3, CASP9, CASP6
39
Show member pathways
8.2TNFSF10, CASP8, CASP3, CASP9, CASP6
40
Show member pathways
8.1KDR, CASP8, CASP3, CASP9, CASP6
41
Show member pathways
8.1KDR, CASP8, CASP3, CASP9, CASP6
428.1PTGS2, CASP8, CASP3, CASP9, CDKN1A, SLC2A1
438.0TYMS, PTGS2, CASP8, CASP3, CASP9, CDKN1A
44
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways61
8.0CDKN1A, TNFSF10, CASP8, CASP3, CASP9, CASP6
45
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
8.0TNFSF10, CASP8, CASP3, CASP9, CASP6, CDKN1A
46
Show member pathways
7.9TNFSF10, KDR, CASP3, CASP9, CASP6, CDKN1A
47
Show member pathways
7.8TNFSF10, KDR, CASP8, CASP3, CASP9, CASP6
48
Show member pathways
7.5TNFSF10, KDR, CASP8, CASP3, CASP9, CASP6
49
Show member pathways
6.9TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP9
50
Show member pathways
6.9TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP9

Compounds for genes affiliated with Thoracic Cancer

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Sources:
46Novoseek, 3BitterDB, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB
See all sources

Compounds related to Thoracic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 211)
idCompoundScoreTop Affiliating Genes
1perifosine469.7TNFSF10, CASP8, CDKN1A, CASP9
2cccp469.6SLC2A1, CASP9, TNFSF10, CASP8
3vitamin e succinate469.2CASP9, TNFSF10, CDKN1A, CASP3, CASP8
4noxa469.2TNFSF10, CASP8, CASP3, CASP9, CDKN1A
5cd 437469.2TNFSF10, CASP8, CASP9, CASP3, CDKN1A
6indole-3-carbinol469.1TNFSF10, CASP9, CASP3, CASP8, CDKN1A
7depsipeptide469.1CASP9, CASP3, CASP8, TNFSF10, CDKN1A
8suberoylanilide hydroxamic acid469.0CASP8, TNFSF10, CASP3, CASP9, CDKN1A
9n-(4-hydroxyphenyl)retinamide469.0CASP3, CDKN1A, CASP8, TNFSF10, CASP9
10sulindac sulfide468.8CASP9, PTGS2, TNFSF10, CASP3, CASP8
11triptolide468.8TNFSF10, PTGS2, CASP8, CASP9, CASP3
12parthenolide46 39.8PTGS2, CASP9, CASP3, TNFSF10, CASP8
13bortezomib46 52 1210.8TNFSF10, KDR, CASP8, CASP3, CASP9, CDKN1A
14tunicamycin46 629.7CASP8, CASP9, SLC2A1, CASP3, TNFSF10
15adriamycin468.7CASP3, CASP9, CASP8, TNFSF10, TYMS, CDKN1A
16mg 13246 629.7TNFSF10, CASP9, KDR, CASP3, CASP8, CDKN1A
17z-vad-fmk46 629.6TNFSF10, CASP8, CASP6, CASP3, CASP9
18az 10417808628.6CASP6, CASP9, CASP3, CASP8
19sulforaphane468.6CASP8, CASP3, PTGS2, CASP9, CDKN1A, TNFSF10
2015-deoxy-delta-12,14-prostaglandin j2468.6CDKN1A, PTGS2, CASP9, CASP3, CASP8, TNFSF10
21z-devd-fmk62 309.6CASP8, CASP6, CASP9, CASP3
22arsenite46 259.5TNFSF10, SLC2A1, CDKN1A, CASP9, CASP3, CASP8
23docetaxel46 52 62 1211.5CASP8, CASP3, CASP9, CDKN1A, KDR, TYMS
24resveratrol46 62 25 1211.5CDKN1A, CASP9, PTGS2, TNFSF10, CASP3, CASP8
25flavopiridol46 129.5CASP9, CDKN1A, CASP3, CASP8, TNFSF10
26imatinib46 52 1210.5TKT, TNFSF10, CDKN1A, CASP3, CASP8, KDR
27z-dqmd-fmk62 309.4CASP8, CASP6, CASP9, CASP3
28troglitazone46 30 62 1211.4SLC2A1, CDKN1A, CASP3, CASP8, PTGS2, TNFSF10
29gefitinib46 52 1210.4CDKN1A, TKT, PTGS2, TNFSF10, TYMS, KDR
30butyrate468.4SLC2A1, CDKN1A, CASP9, CASP3, CASP8, TNFSF10
31curcumin468.3CASP8, CDKN1A, CASP9, CASP3, TNFSF10, PTGS2
32wortmannin468.3CASP8, KDR, CASP3, SLC2A1, TNFSF10, CASP9
33rapamycin468.3TKT, TNFSF10, KDR, CASP3, CASP9, CDKN1A
34celecoxib46 62 30 52 25 1213.2CASP9, CASP3, CASP8, KDR, PTGS2, CDKN1A
35doxorubicin46 52 1210.2TYMS, CASP8, KDR, TNFSF10, CASP3, CDKN1A
36n acetylcysteine468.1PTGS2, TNFSF10, KDR, CASP8, CASP3, CDKN1A
37pd 98,059468.1TNFSF10, PTGS2, CASP8, CASP9, SLC2A1, CDKN1A
38actinomycin d468.0TNFSF10, SLC2A1, CASP9, CASP3, CDKN1A, CASP8
395fluorouracil467.9TNFSF10, CASP8, CASP3, TKT, SLC2A1, KDR
40egcg467.8SLC2A1, CASP3, CASP8, KDR, PTGS2, TNFSF10
41ly294002467.8CDKN1A, CASP3, TNFSF10, PTGS2, KDR, CASP8
42genistein46 30 62 3 25 1212.8TKT, CASP9, CDKN1A, CASP3, KDR, PTGS2
43gemcitabine46 52 129.7CASP3, CASP8, KDR, PTGS2, CDKN1A, TNFSF10
44camptothecin46 62 129.5TNFSF10, CDKN1A, CASP6, CASP9, CASP3, CASP8
45paclitaxel46 52 129.5CASP8, CASP6, CDKN1A, TNFSF10, CASP9, CASP3
46vegf467.1CASP3, PTGS2, KDR, CDKN1A, MSLN, TNFSF10
47etoposide46 52 62 1210.0TKT, CDKN1A, CASP6, CASP9, TYMS, CASP3
48serine466.7CASP9, CASP8, KDR, TNFSF10, TYMS, CDKN1A
49cycloheximide466.6SLC2A1, TKT, TYMS, TNFSF10, PTGS2, CASP8
50cisplatin46 52 62 129.2SLC2A1, TKT, CDKN1A, CASP6, CASP9, CASP3

GO Terms for genes affiliated with Thoracic Cancer

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Sources:
17Gene Ontology
See all sources

Cellular components related to Thoracic Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056347.2PTGS2, KDR, CASP8, CASP3, CASP9, CDKN1A
2cytosolGO:0058297.2TKT, TYMS, CASP8, CASP3, CASP9, CASP6

Biological processes related to Thoracic Cancer according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1response to cobalt ionGO:03202510.2CASP8, CASP9
2regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.2TNFSF10, CASP8
3positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.0TNFSF10, CASP8
4glial cell apoptotic processGO:03434910.0CASP9, CASP3
5response to antibioticGO:04667710.0CASP9, CASP8
6activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:00863510.0CASP3, CASP9
7platelet formationGO:03022010.0CASP3, CASP9
8negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.9CDKN1A, CASP3
9execution phase of apoptosisGO:0971949.9CASP3, CASP8
10phosphatidylinositol-mediated signalingGO:0480159.8CDKN1A, CASP9, TYMS
11extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.7CASP3, CASP8
12cellular response to UVGO:0346449.7CASP9, PTGS2
13cellular response to DNA damage stimulusGO:0069749.7CASP3, CASP9, CDKN1A
14apoptotic signaling pathwayGO:0971909.7CASP3, CASP8, TNFSF10
15response to estradiolGO:0323559.6CASP9, CASP8, PTGS2
16response to UVGO:0094119.6CDKN1A, CASP3
17response to lipopolysaccharideGO:0324969.6CASP9, CASP8, PTGS2
18intrinsic apoptotic signaling pathwayGO:0971939.5CDKN1A, CASP9, CASP3, CASP8
19neurotrophin TRK receptor signaling pathwayGO:0480119.4CASP3, CASP9, CDKN1A
20response to tumor necrosis factorGO:0346129.4CASP3, CASP8, PTGS2
21positive regulation of neuron apoptotic processGO:0435259.4CASP9, CASP3
22angiogenesisGO:0015259.4CASP8, KDR, PTGS2
23cellular component disassembly involved in execution phase of apoptosisGO:0069219.2CASP8, CASP3, CASP6
24response to drugGO:0424939.1CDKN1A, PTGS2, TYMS
25proteolysisGO:0065089.1CASP8, CASP3, CASP6
26positive regulation of apoptotic processGO:0430659.1CASP9, CASP3, PTGS2, TNFSF10
27apoptotic processGO:0069158.6CASP6, CASP9, CASP3, CASP8, TNFSF10

Molecular functions related to Thoracic Cancer according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.9CASP8, TNFSF10
2cysteine-type endopeptidase activity involved in apoptotic processGO:0971539.7CASP3, CASP8
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.6CASP3, CDKN1A
4peptidase activityGO:0082339.5CASP8, CASP3, CASP9
5cofactor bindingGO:0480379.3TKT, TYMS
6cysteine-type endopeptidase activityGO:0041978.7CASP6, CASP9, CASP3, CASP8
7protein bindingGO:0055156.7TNFSF10, KDR, MSLN, CASP8, CASP3, CASP9

Products for genes affiliated with Thoracic Cancer

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Sources for Thoracic Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet