MCID: THR012
MIFTS: 46

Thoracic Cancer malady

Cancer diseases, Respiratory diseases categories

Summaries for Thoracic Cancer

About this section


Disease Ontology:9 An organ system cancer located in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.

MalaCards based summary: Thoracic Cancer, also known as malignant neoplasm of thorax, is related to malignant pleural mesothelioma and lung cancer. An important gene associated with Thoracic Cancer is CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1)), and among its related pathways are Death Receptor Signalling and Activation of caspases through apoptosome-mediated cleavage. The compounds perifosine and cccp have been mentioned in the context of this disorder. Affiliated tissues include the thoracic cavity, lung and trachea, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Thoracic Cancer

About this section
Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH
See all sources

Thoracic Cancer, Aliases & Descriptions:

Name: Thoracic Cancer 9 43
Malignant Neoplasm of Thorax 60
Thoracic Neoplasms 60
Thorax Neoplasm 9
 
Tumor of Thorax 9
Thoracic Tumor 9
Thorax Cancer 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology9 DOID:5093
NCIt38 C3406
MeSH33 D013899

Related Diseases for Thoracic Cancer

About this section

Diseases in the Thoracic Cancer family:

Thoracic Benign Neoplasm

Diseases related to Thoracic Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1malignant pleural mesothelioma30.1TYMS, MSLN
2lung cancer30.0PTGS2, CDKN1A, TYMS
3endometriosis29.9CASP9, KDR, PTGS2
4mesothelioma29.8TKT, MSLN, TYMS, TNFSF10
5breast cancer28.3CDKN1A, CASP9, SLC2A1, CASP3, KDR, TYMS
6capillary hemangioma10.4SLC2A1
7myocardial infarction10.4PTGS2
8thyroid carcinoma, follicular10.3KDR, CDKN1A
9benign mesothelioma10.2TYMS, MSLN
10rectal neoplasm10.2CDKN1A, TYMS
11hemangioblastoma10.2SLC2A1, KDR
12fibrosarcoma10.1TNFSF10, CDKN1A, TKT
13cerebral hypoxia10.1CASP9, CASP3
14transitional cell carcinoma10.1CDKN1A, PTGS2, SLC2A1
15cholangiocarcinoma10.1CASP9, TNFSF10, PTGS2
16renal clear cell carcinoma10.1SLC2A1, KDR, CASP8
17bladder transitional cell carcinoma10.0SLC2A1, CASP3
18endometrial cancer10.0TNFSF10, SLC2A1, CDKN1A, CASP9
19acute leukemia10.0TKT, CASP8, TNFSF10
20hematologic cancer10.0TKT, TNFSF10, KDR
21multiple sclerosis, disease progression, modifier of10.0TNFSF10, CASP9, CASP8
22huntington disease10.0CASP3, CASP6, CASP8
23glioblastoma multiforme10.0TNFSF10, CDKN1A, KDR, CASP8
24chest wall lymphoma10.0
25cervicitis10.0
26mediastinal cancer10.0
27pleurisy9.9
28acute adrenal insufficiency9.9
29chronic lymphocytic leukemia9.9CASP3, TNFSF10, CASP8
30nasopharyngeal carcinoma9.9TKT, CASP9, CASP3
31hiv-19.9TKT, TYMS, CASP8
32bladder cancer, somatic9.9TKT, TYMS, TNFSF10, CDKN1A
33tuberculosis9.9CASP9, TKT, TYMS, CASP8
34thyroid cancer, anaplastic9.9CASP8, TNFSF10, CASP3, CDKN1A
35mesothelioma, somatic9.9MSLN, KDR, TNFSF10, TYMS
36sarcoma9.8TKT, CASP9, KDR
37prostate cancer9.8CASP3, CASP8, TNFSF10, CDKN1A
38hyperglycemia9.8TKT, SLC2A1, CASP3
39medulloblastoma9.8CASP3, CASP8, TNFSF10, CASP9
40precursor t-cell acute lymphoblastic leukemia9.8CASP3, TNFSF10, TYMS
41small cell cancer of the lung, somatic9.8CASP8, KDR, CASP3
42lung benign neoplasm9.8TKT, CASP3, KDR
43congenital heart disease9.8CASP9, TKT, SLC2A1
44parkinson disease, late-onset9.8CASP9, CASP8, CASP3
45oral cancer9.8CASP9, CDKN1A, PTGS2, CASP3
46cowpox9.8TKT, CASP3, CASP8, TNFSF10
47thyroid cancer9.8SLC2A1, TKT, KDR, TNFSF10, CDKN1A
48leukemia, acute promyelocytic9.7CASP8, CDKN1A, CASP3, TNFSF10, CASP9
49myeloid leukemia9.7CDKN1A, TNFSF10, CASP8, CASP3, CASP9
50myeloma9.7CASP8, CASP9, CASP3, TNFSF10, CDKN1A

Graphical network of the top 20 diseases related to Thoracic Cancer:



Diseases related to thoracic cancer

Symptoms for Thoracic Cancer

About this section

Drugs & Therapeutics for Thoracic Cancer

About this section

Drug clinical trials:

Search ClinicalTrials for Thoracic Cancer

Search NIH Clinical Center for Thoracic Cancer

Genetic Tests for Thoracic Cancer

About this section

Anatomical Context for Thoracic Cancer

About this section

MalaCards organs/tissues related to Thoracic Cancer:

31
Lung, Trachea

FMA organs/tissues related to Thoracic Cancer:

14
The thoracic cavity

Animal Models for Thoracic Cancer or affiliated genes

About this section

MGI Mouse Phenotypes related to Thoracic Cancer:

35 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5TNFSF10, PTGS2, KDR, CASP8, CDKN1A, TKT
2MP:00053678.5PTGS2, CASP8, CASP3, CDKN1A, TKT
3MP:00053808.4PTGS2, KDR, CASP8, CASP9, CDKN1A, SLC2A1
4MP:00053698.4CDKN1A, CASP3, CASP8, KDR, PTGS2
5MP:00107718.4CDKN1A, CASP3, CASP8, KDR, PTGS2
6MP:00053888.3PTGS2, KDR, CASP8, CASP3, CASP9, CDKN1A
7MP:00053798.3PTGS2, CASP8, CASP3, CDKN1A, TKT
8MP:00053908.0TNFSF10, PTGS2, KDR, CASP3, CDKN1A
9MP:00053858.0PTGS2, KDR, CASP8, CASP3, CASP9, CDKN1A
10MP:00053978.0TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP9
11MP:00053877.9TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP9
12MP:00030127.8PTGS2, KDR, CASP3, CASP6, CDKN1A, SLC2A1
13MP:00053917.7PTGS2, KDR, CASP3, CASP6, CDKN1A, TKT
14MP:00107687.3TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP9
15MP:00053867.3PTGS2, KDR, CASP3, CASP6, CDKN1A, TKT
16MP:00053847.2PTGS2, KDR, CASP8, CASP3, CASP9, CASP6
17MP:00053767.1TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP6
18MP:00036316.9SLC2A1, PTGS2, KDR, CASP8, CASP3, CASP9
19MP:00053786.8PTGS2, KDR, CASP8, CASP3, CASP9, CASP6

Publications for Thoracic Cancer

About this section

Articles related to Thoracic Cancer:

(show all 38)
idTitleAuthorsYear
1
Preferences for disclosure of disease related information among thoracic cancer patients. (25682317)
2015
2
New histone deacetylase inhibitors improve cisplatin antitumor properties against thoracic cancer cells. (24980825)
2014
3
Comparison of timing and decision-makers of do-not-resuscitate orders between thoracic cancer and non-cancer respiratory disease patients dying in a Japanese acute care hospital. (24414996)
2014
4
Advantages of simulating thoracic cancer patients in an upright position. (24621432)
2014
5
Predictors of smoking relapse in patients with thoracic cancer or head and neck cancer. (23280005)
2013
6
Objected constrained registration and manifold learning: a new patient setup approach in image guided radiation therapy of thoracic cancer. (23556880)
2013
7
Providing nutritional support to patients with thoracic cancer: findings of a dedicated rehabilitation service. (23452729)
2013
8
IMRT treatment plans and functional planning with functional lung imaging from 4D-CT for thoracic cancer patients. (23281734)
2013
9
Occupational therapy needs of patients with thoracic cancer at the time of diagnosis: findings of a dedicated rehabilitation service. (23269421)
2013
10
A study of respiration-correlated cone-beam CT scans to correct target positioning errors in radiotherapy of thoracic cancer. (23039621)
2012
11
Exploring physical activity level in patients with thoracic cancer: implications for use as an outcome measure. (22311375)
2012
12
Factors influencing exercise performance in thoracic cancer. (22104542)
2012
13
Role of cervical cordotomy and other neurolytic procedures in thoracic cancer pain. (20019619)
2010
14
Identifying supportive and palliative care needs in people with a recent diagnosis of thoracic cancer: acceptability of the SPARC questionnaire. (20671310)
2010
15
Emerging role of thymidylate synthase for the pharmacogenomic selection of patients with thoracic cancer. (20557852)
2010
16
Thoracic cancer surgeries. (19553762)
2009
17
Targeting HER pathway in head and neck and thoracic cancers]. (19433372)
2009
18
Functional lung imaging in thoracic cancer radiotherapy. (18376378)
2008
19
Use of a Cybex NORM dynamometer to assess muscle function in patients with thoracic cancer. (18402699)
2008
20
Other thoracic cancers. Malignant pleural mesothelioma: biology and diagnosis]. (18971844)
2008
21
Patient participation in thoracic cancer clinical trials. (18166833)
2008
22
Survival improvement in thoracic cancer: progress from the last decade and beyond. (17686443)
2007
23
Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. (17136498)
2007
24
Clinical significance of integrated PET/CT in the diagnosis of thoracic cancers]. (17763680)
2007
25
Influence of preoperative exercise capacity on length of stay after thoracic cancer surgery. (17588411)
2007
26
The essential role of the mitochondria-dependent death-signaling cascade in chemotherapy-induced potentiation of Apo2L/TRAIL cytotoxicity in cultured thoracic cancer cells: amplified caspase 8 is indispensable for combination-mediated massive cell death. (16925970)
2006
27
Valproic acid, an antiepileptic drug with histone deacetylase inhibitory activity, potentiates the cytotoxic effect of Apo2L/TRAIL on cultured thoracic cancer cells through mitochondria-dependent caspase activation. (16820090)
2006
28
Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. (17140955)
2006
29
Pemetrexed in thoracic cancer. (16634714)
2006
30
New investigative regimens and cytotoxic agents in thoracic cancers: gemcitabine and pemetrexed. (15339053)
2004
31
Gemcitabine, pemetrexed, and novel agents in the treatment of thoracic cancer. Selected presentations from the 10th World Congress on Lung Cancer. Vancouver, Canada. (15675032)
2004
32
Combination of a COX-2 inhibitor with radiotherapy or radiochemotherapy in the treatment of thoracic cancer. (12902863)
2003
33
Comparison of (11)C-choline and (18)F-FDG PET in primary diagnosis and staging of patients with thoracic cancer. (11850480)
2002
34
Technical aspects of the deep inspiration breath-hold technique in the treatment of thoracic cancer. (11072177)
2000
35
Antifungal therapy in thoracic cancer patients with low dose liposomal amphotericin B (AmBisome). (11118876)
2000
36
Balance of proinflammatory and antiinflammatory cytokines at thoracic cancer operation. (9800796)
1998
37
Thoracic cancer surgery in the elderly. (9800968)
1998
38
Photodynamic therapy for thoracic cancer: biology and applications. (7688984)
1993

Variations for Thoracic Cancer

About this section

Expression for genes affiliated with Thoracic Cancer

About this section
Search GEO for disease gene expression data for Thoracic Cancer.

Pathways for genes affiliated with Thoracic Cancer

About this section

Pathways related to Thoracic Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9CASP8, TNFSF10
2
Show member pathways
9.7CASP9, CASP3
3
Show member pathways
Signal transduction PTEN pathway58
9.4CDKN1A, CASP9, CASP3
4
Show member pathways
9.4CASP8, CASP3, CASP9
59.4CASP8, CASP3, CASP9
69.4CASP9, CASP3, CASP8
7
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.4CASP9, CASP3, CASP8
8
Show member pathways
9.4CASP9, CASP3, CASP8
9
Show member pathways
TRAIL signaling pathway36
9.3CASP3, CASP8, TNFSF10
109.3CDKN1A, CASP3, KDR
11
Show member pathways
DNA damage response36
9.1CASP8, CASP3, CASP9, CDKN1A
12
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.1CASP8, CASP3, CASP9, CDKN1A
13
Show member pathways
9.0TNFSF10, CASP8, CASP3, CASP9
149.0CASP9, CASP3, CASP8, TNFSF10
159.0PTGS2, CASP8, CASP3
16
Show member pathways
8.8CASP6, CASP9, CASP3
178.8CASP6, CASP9, CASP3
188.8CASP3, CASP9, CASP6
19
Show member pathways
8.8CASP8, CASP3, CASP6
208.8PTGS2, CASP3, CASP9, CDKN1A
218.8PTGS2, CASP3, CASP9, CDKN1A
228.8PTGS2, CASP6, CDKN1A
23
Show member pathways
8.7CASP9, CASP3, CASP8, PTGS2
24
Show member pathways
8.5CASP8, CASP3, CASP9, CASP6
25
Show member pathways
MAPK signaling pathway36
8.5CASP8, CASP3, CASP9, CASP6
26
Show member pathways
8.5CASP8, CASP3, CASP9, CASP6
278.5CASP6, CASP9, CASP3, CASP8
288.5CASP6, CASP9, CASP3, CASP8
29
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
8.5CASP6, CASP9, CASP3, CASP8
30
Show member pathways
8.5CASP8, CASP3, CASP9, CASP6
31
Show member pathways
8.5CASP8, CASP3, CASP9, CASP6
32
Show member pathways
8.5TNFSF10, CASP3, CASP9, CASP6
33
Show member pathways
8.3CASP8, CASP3, CASP9, CASP6, CDKN1A
34
Show member pathways
8.2TNFSF10, CASP8, CASP3, CASP9, CASP6
35
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.2TNFSF10, CASP8, CASP3, CASP9, CASP6
36
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
8.2TNFSF10, CASP8, CASP3, CASP9, CASP6
378.2TNFSF10, CASP8, CASP3, CASP9, CASP6
38
Show member pathways
8.2TNFSF10, CASP8, CASP3, CASP9, CASP6
39
Show member pathways
8.1KDR, CASP8, CASP3, CASP9, CASP6
40
Show member pathways
8.1KDR, CASP8, CASP3, CASP9, CASP6
418.1PTGS2, CASP8, CASP3, CASP9, CDKN1A, SLC2A1
428.0TYMS, PTGS2, CASP8, CASP3, CASP9, CDKN1A
43
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
8.0CDKN1A, TNFSF10, CASP8, CASP3, CASP9, CASP6
44
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.0TNFSF10, CASP8, CASP3, CASP9, CASP6, CDKN1A
45
Show member pathways
7.9TNFSF10, KDR, CASP3, CASP9, CASP6, CDKN1A
46
Show member pathways
7.8TNFSF10, KDR, CASP8, CASP3, CASP9, CASP6
47
Show member pathways
7.5TNFSF10, KDR, CASP8, CASP3, CASP9, CASP6
48
Show member pathways
6.9TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP9
49
Show member pathways
6.9TNFSF10, PTGS2, KDR, CASP8, CASP3, CASP9

Compounds for genes affiliated with Thoracic Cancer

About this section

Compounds related to Thoracic Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 211)
idCompoundScoreTop Affiliating Genes
1perifosine439.7TNFSF10, CASP8, CDKN1A, CASP9
2cccp439.6SLC2A1, CASP9, TNFSF10, CASP8
3vitamin e succinate439.2CASP9, TNFSF10, CDKN1A, CASP3, CASP8
4noxa439.2TNFSF10, CASP8, CASP3, CASP9, CDKN1A
5cd 437439.2TNFSF10, CASP8, CASP9, CASP3, CDKN1A
6indole-3-carbinol439.1TNFSF10, CASP9, CASP3, CASP8, CDKN1A
7depsipeptide439.1CASP9, CASP3, CASP8, TNFSF10, CDKN1A
8suberoylanilide hydroxamic acid439.0CASP8, TNFSF10, CASP3, CASP9, CDKN1A
9n-(4-hydroxyphenyl)retinamide439.0CASP3, CDKN1A, CASP8, TNFSF10, CASP9
10sulindac sulfide438.8CASP9, PTGS2, TNFSF10, CASP3, CASP8
11triptolide438.8TNFSF10, PTGS2, CASP8, CASP9, CASP3
12parthenolide43 29.8PTGS2, CASP9, CASP3, TNFSF10, CASP8
13bortezomib43 49 1210.8TNFSF10, KDR, CASP8, CASP3, CASP9, CDKN1A
14tunicamycin43 599.7CASP8, CASP9, SLC2A1, CASP3, TNFSF10
15adriamycin438.7CASP3, CASP9, CASP8, TNFSF10, TYMS, CDKN1A
16mg 13243 599.7TNFSF10, CASP9, KDR, CASP3, CASP8, CDKN1A
17z-vad-fmk43 599.6TNFSF10, CASP8, CASP6, CASP3, CASP9
18az 10417808598.6CASP6, CASP9, CASP3, CASP8
19sulforaphane438.6CASP8, CASP3, PTGS2, CASP9, CDKN1A, TNFSF10
2015-deoxy-delta-12,14-prostaglandin j2438.6CDKN1A, PTGS2, CASP9, CASP3, CASP8, TNFSF10
21z-devd-fmk59 289.6CASP8, CASP6, CASP9, CASP3
22arsenite43 249.5TNFSF10, SLC2A1, CDKN1A, CASP9, CASP3, CASP8
23docetaxel43 49 59 1211.5CASP8, CASP3, CASP9, CDKN1A, KDR, TYMS
24resveratrol43 59 24 1211.5CDKN1A, CASP9, PTGS2, TNFSF10, CASP3, CASP8
25flavopiridol43 129.5CASP9, CDKN1A, CASP3, CASP8, TNFSF10
26imatinib43 49 1210.5TKT, TNFSF10, CDKN1A, CASP3, CASP8, KDR
27z-dqmd-fmk59 289.4CASP8, CASP6, CASP9, CASP3
28troglitazone43 28 59 1211.4SLC2A1, CDKN1A, CASP3, CASP8, PTGS2, TNFSF10
29gefitinib43 49 1210.4CDKN1A, TKT, PTGS2, TNFSF10, TYMS, KDR
30butyrate438.4SLC2A1, CDKN1A, CASP9, CASP3, CASP8, TNFSF10
31curcumin438.3CASP8, CDKN1A, CASP9, CASP3, TNFSF10, PTGS2
32wortmannin438.3CASP8, KDR, CASP3, SLC2A1, TNFSF10, CASP9
33rapamycin438.3TKT, TNFSF10, KDR, CASP3, CASP9, CDKN1A
34celecoxib43 59 28 49 24 1213.2CASP9, CASP3, CASP8, KDR, PTGS2, CDKN1A
35doxorubicin43 49 1210.2TYMS, CASP8, KDR, TNFSF10, CASP3, CDKN1A
36n acetylcysteine438.1PTGS2, TNFSF10, KDR, CASP8, CASP3, CDKN1A
37pd 98,059438.1TNFSF10, PTGS2, CASP8, CASP9, SLC2A1, CDKN1A
38actinomycin d438.0TNFSF10, SLC2A1, CASP9, CASP3, CDKN1A, CASP8
395fluorouracil437.9TNFSF10, CASP8, CASP3, TKT, SLC2A1, KDR
40egcg437.8SLC2A1, CASP3, CASP8, KDR, PTGS2, TNFSF10
41ly294002437.8CDKN1A, CASP3, TNFSF10, PTGS2, KDR, CASP8
42genistein43 28 59 2 24 1212.8TKT, CASP9, CDKN1A, CASP3, KDR, PTGS2
43gemcitabine43 49 129.7CASP3, CASP8, KDR, PTGS2, CDKN1A, TNFSF10
44camptothecin43 59 129.5TNFSF10, CDKN1A, CASP6, CASP9, CASP3, CASP8
45paclitaxel43 49 129.5CASP8, CASP6, CDKN1A, TNFSF10, CASP9, CASP3
46vegf437.1CASP3, PTGS2, KDR, CDKN1A, MSLN, TNFSF10
47etoposide43 49 59 1210.0TKT, CDKN1A, CASP6, CASP9, TYMS, CASP3
48serine436.7CASP9, CASP8, KDR, TNFSF10, TYMS, CDKN1A
49cycloheximide436.6SLC2A1, TKT, TYMS, TNFSF10, PTGS2, CASP8
50cisplatin43 49 59 129.2SLC2A1, TKT, CDKN1A, CASP6, CASP9, CASP3

GO Terms for genes affiliated with Thoracic Cancer

About this section

Cellular components related to Thoracic Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056347.2PTGS2, KDR, CASP8, CASP3, CASP9, CDKN1A
2cytosolGO:00058297.2TKT, TYMS, CASP8, CASP3, CASP9, CASP6

Biological processes related to Thoracic Cancer according to GeneCards Suite gene sharing:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1response to cobalt ionGO:003202510.2CASP8, CASP9
2regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:0200123910.2TNFSF10, CASP8
3positive regulation of extrinsic apoptotic signaling pathwayGO:0200123810.0TNFSF10, CASP8
4glial cell apoptotic processGO:003434910.0CASP9, CASP3
5response to antibioticGO:004667710.0CASP9, CASP8
6activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:000863510.0CASP3, CASP9
7platelet formationGO:003022010.0CASP3, CASP9
8negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:00457369.9CDKN1A, CASP3
9execution phase of apoptosisGO:00971949.9CASP3, CASP8
10phosphatidylinositol-mediated signalingGO:00480159.8CDKN1A, CASP9, TYMS
11extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.7CASP3, CASP8
12cellular response to UVGO:00346449.7CASP9, PTGS2
13cellular response to DNA damage stimulusGO:00069749.7CASP3, CASP9, CDKN1A
14apoptotic signaling pathwayGO:00971909.7CASP3, CASP8, TNFSF10
15response to estradiolGO:00323559.6CASP9, CASP8, PTGS2
16response to UVGO:00094119.6CDKN1A, CASP3
17response to lipopolysaccharideGO:00324969.6CASP9, CASP8, PTGS2
18intrinsic apoptotic signaling pathwayGO:00971939.5CDKN1A, CASP9, CASP3, CASP8
19neurotrophin TRK receptor signaling pathwayGO:00480119.4CASP3, CASP9, CDKN1A
20response to tumor necrosis factorGO:00346129.4CASP3, CASP8, PTGS2
21positive regulation of neuron apoptotic processGO:00435259.4CASP9, CASP3
22angiogenesisGO:00015259.4CASP8, KDR, PTGS2
23cellular component disassembly involved in execution phase of apoptosisGO:00069219.2CASP8, CASP3, CASP6
24response to drugGO:00424939.1CDKN1A, PTGS2, TYMS
25proteolysisGO:00065089.1CASP8, CASP3, CASP6
26positive regulation of apoptotic processGO:00430659.1CASP9, CASP3, PTGS2, TNFSF10
27apoptotic processGO:00069158.6CASP6, CASP9, CASP3, CASP8, TNFSF10

Molecular functions related to Thoracic Cancer according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.9CASP8, TNFSF10
2cysteine-type endopeptidase activity involved in apoptotic processGO:00971539.7CASP3, CASP8
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048619.6CASP3, CDKN1A
4peptidase activityGO:00082339.5CASP8, CASP3, CASP9
5cofactor bindingGO:00480379.3TKT, TYMS
6cysteine-type endopeptidase activityGO:00041978.7CASP6, CASP9, CASP3, CASP8
7protein bindingGO:00055156.7TNFSF10, KDR, MSLN, CASP8, CASP3, CASP9

Products for genes affiliated with Thoracic Cancer

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Thoracic Cancer

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet