TOS
MCID: THR013

Thoracic Outlet Syndrome malady

Summaries for Thoracic Outlet Syndrome

Sources:
30NIH Rare Diseases, 23MedlinePlus, 31NINDS, 44Wikipedia, 22MalaCards
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MedlinePlus: If you have thoracic outlet syndrome (tos), the nerves or blood vessels just below your neck are compressed, or squeezed. it can be between the muscles of your neck and shoulder or between the first rib and collarbone. you may feel burning, tingling and numbness along your arm, hand, and fingers. if a nerve is compressed, you may also feel weakness in your hand. if a vein is compressed, your hand might be sensitive to cold, or turn pale or bluish. your arm might swell and tire easily. tos can be a repetitive stress injury. an extra rib, scar tissue, traumatic injury or inherited defects can also cause tos. treatment depends on what caused your tos. medicines, physical therapy and relaxation might help. surgery may also be an option. most people recover. nih: national institute of neurological disorders and stroke23

MalaCards: Thoracic Outlet Syndrome, also known as tos - thoracic outlet syndrome, is related to arteriovenous malformation and candida glabrata. An important gene associated with Thoracic Outlet Syndrome is MRPL49 (mitochondrial ribosomal protein L49). The compound glutamate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related mouse phenotypes are renal/urinary system and skeleton.

NIH Rare Diseases: Thoracic outlet syndrome (TOS) describes a group of conditions that are characterized by compression of the nerves, arteries, and veins in the lower neck and upper chest area. This can result in pain in the arms, shoulders, and neck. Currently, there is considerable disagreement about its diagnosis and treatment. A number of disorders have symptoms similar to those of TOS, including rotator cuff injuries, fibromyalgia, multiple sclerosis, complex regional pain syndrome, and tumors of the syrinx or spinal cord. Symptoms of this condition vary depending on the type. The different types include neurogenic, venous, and arterial thoracic outlet syndrome. There are many different causes of TOC. Symptoms usually occur between 20 and 50 years of age.30

NINDS: TOS is an umbrella term that encompasses three related syndromes that involve compression of the nerves, arteries, and veins in the lower neck and upper chest area and cause pain in the arm, shoulder, and neck. 31

Wikipedia: Thoracic outlet syndrome (TOS) is a syndrome involving compression at the superior thoracic outlet...44 more...

Aliases & Descriptions for Thoracic Outlet Syndrome

Sources:
6Disease Ontology, 30NIH Rare Diseases, 31NINDS, 8DISEASES, 23MedlinePlus, 43UMLS, 24MeSH, 40SNOMED-CT, 27NCIt
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Aliases & Descriptions:

thoracic outlet syndrome 6 30 31 8 23 43
tos - thoracic outlet syndrome 6
tos 30

Related Diseases for Thoracic Outlet Syndrome

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13GeneCards, 14GeneDecks
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Graphical network of the top 20 diseases related to thoracic outlet syndrome:



Graphical network of diseases related to thoracic outlet syndrome

Clinical Features for Thoracic Outlet Syndrome

Drugs & Therapeutics for Thoracic Outlet Syndrome

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials
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Approved drugs:

Search CenterWatch for thoracic outlet syndrome

Drug clinical trials:

Search ClinicalTrials for thoracic outlet syndrome

Search NIH Clinical Center for thoracic outlet syndrome

Search CenterWatch for thoracic outlet syndrome

Genetic Tests for Thoracic Outlet Syndrome

Anatomical Context for Thoracic Outlet Syndrome

Sources:
22MalaCards
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MalaCards organs/tissues related to thoracic outlet syndrome:

22
Spinal cord

Phenotypes for genes affiliated with Thoracic Outlet Syndrome

Sources:
25MGI
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MGI Mouse Phenotypes related to thoracic outlet syndrome:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1renal/urinary system phenotypeMP:00053678.4NCOA1, KIAA1217, FMN1, PNP
2skeleton phenotypeMP:00053907.2NCOA1, KIAA1217, FMN1, PLAT, HHAT

Publications for genes affiliated with Thoracic Outlet Syndrome

Sources:
35PubMed
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Articles related to thoracic outlet syndrome:

idTitleAuthorsYearAffiliating Genes
1Multiple treatment algorithms for successful outcomes in venous thoracic outlet syndrome. (19375608)de LeA^n R.A.... Freischlag J.A.2009PLAT

Expression for genes affiliated with Thoracic Outlet Syndrome

Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with Thoracic Outlet Syndrome

Pathways for genes affiliated with Thoracic Outlet Syndrome

Compounds for genes affiliated with Thoracic Outlet Syndrome

Sources:
32Novoseek
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Compounds related to thoracic outlet syndrome according to GeneDecks:

idCompoundScoreTop Affiliating Genes
1glutamate32 8.5NCOA1, FMN1, PNP, PLAT

GO Terms for genes affiliated with Thoracic Outlet Syndrome

Sources for Thoracic Outlet Syndrome

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS