MCID: THR013
MIFTS: 45

Thoracic Outlet Syndrome malady

Rare diseases category

Aliases & Classifications for Thoracic Outlet Syndrome

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 42NINDS, 11DISEASES, 47Orphanet, 32MedlinePlus, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Thoracic Outlet Syndrome, Aliases & Descriptions:

Name: Thoracic Outlet Syndrome 9 41 42 11 47 32 60
Thoracic Outlet Compression Syndrome 41 47
 
Tos 41 47
Tos - Thoracic Outlet Syndrome 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:3103
NCIt38 C85188
MeSH33 D013901
Orphanet47 97330
MESH via Orphanet34 D013901
ICD10 via Orphanet26 G54.0
UMLS via Orphanet61 C0039984

Summaries for Thoracic Outlet Syndrome

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MedlinePlus:32 Thoracic outlet syndrome (tos) causes pain in the arm, shoulder, and neck. it happens when the nerves or blood vessels just below your neck are compressed, or squeezed. the compression can happen between the muscles of your neck and shoulder or between the first rib and collarbone. you may feel burning, tingling, and numbness along your arm, hand, and fingers. if a nerve is compressed, you may also feel weakness in your hand. if a vein is compressed, your hand might be sensitive to cold, or turn pale or bluish. your arm might swell and tire easily. tos is more common in women. it usually starts between 20 and 50 years of age. doctors do nerve and imaging studies to diagnose it. there are many causes of tos, including injury anatomical defects tumors that press on nerves poor posture that causes nerve compression pregnancy repetitive arm and shoulder movements and activity, such as from playing certain sports treatment depends on what caused your tos. medicines, physical therapy, and relaxation might help. surgery may also be an option. most people recover. nih: national institute of neurological disorders and stroke

MalaCards based summary: Thoracic Outlet Syndrome, also known as thoracic outlet compression syndrome, is related to hepatitis and leukemia, and has symptoms including paresthesia, abnormality of the ribs and edema. An important gene associated with Thoracic Outlet Syndrome is PLAT (plasminogen activator, tissue). Affiliated tissues include spinal cord, testes and bone, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:9 A vascular disease that is characterized by compression at the superior thoracic outlet[1] resulting from excess pressure placed on a neurovascular bundle passing between the anterior scalene and middle scalene muscles.

NIH Rare Diseases:41 Thoracic outlet syndrome (tos) describes a group of conditions that are characterized by compression of the nerves, arteries, and veins in the lower neck and upper chest area. this can result in pain in the arms, shoulders, and neck. currently, there is considerable disagreement about its diagnosis and treatment. a number of disorders have symptoms similar to those of tos, including rotator cuff injuries, fibromyalgia, multiple sclerosis, complex regional pain syndrome, and tumors of the syrinx or spinal cord. symptoms of this condition vary depending on the type. the different types include neurogenic, venous, and arterial thoracic outlet syndrome. there are many different causes of toc. symptoms usually occur between 20 and 50 years of age. last updated: 1/26/2012

NINDS:42 TOS is an umbrella term that encompasses three related syndromes that involve compression of the nerves, arteries, and veins in the lower neck and upper chest area and cause pain in the arm, shoulder, and neck.

Wikipedia:63 Thoracic outlet syndrome (TOS) is a syndrome involving compression at the superior thoracic outlet... more...

Related Diseases for Thoracic Outlet Syndrome

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Graphical network of the top 20 diseases related to Thoracic Outlet Syndrome:



Diseases related to thoracic outlet syndrome

Symptoms for Thoracic Outlet Syndrome

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Symptoms:

 47 (show all 14)
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • anomalies of the ribs
  • cutaneous edema
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • muscle weakness/flaccidity
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • venous thrombosis/phlebitis/thrombophlebitis
  • varices/varicous veins/venous insufficiency
  • acute ischemic syndrome
  • motor deficit/trouble
  • sensitive trouble/deficit
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • abnormal emg/electromyogram/electropmyography

HPO human phenotypes related to Thoracic Outlet Syndrome:

(show all 11)
id Description Frequency HPO Source Accession
1 paresthesia hallmark (90%) HP:0003401
2 abnormality of the ribs typical (50%) HP:0000772
3 edema typical (50%) HP:0000969
4 acrocyanosis typical (50%) HP:0001063
5 muscle weakness typical (50%) HP:0001324
6 arthralgia typical (50%) HP:0002829
7 myalgia typical (50%) HP:0003326
8 flexion contracture occasional (7.5%) HP:0001371
9 emg abnormality occasional (7.5%) HP:0003457
10 thrombophlebitis occasional (7.5%) HP:0004418
11 venous insufficiency occasional (7.5%) HP:0005293

Drugs & Therapeutics for Thoracic Outlet Syndrome

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Drug clinical trials:

Search ClinicalTrials for Thoracic Outlet Syndrome

Search NIH Clinical Center for Thoracic Outlet Syndrome

Genetic Tests for Thoracic Outlet Syndrome

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Anatomical Context for Thoracic Outlet Syndrome

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MalaCards organs/tissues related to Thoracic Outlet Syndrome:

31
Spinal cord, Testes, Bone, Breast, Bone marrow, Appendix

Animal Models for Thoracic Outlet Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Thoracic Outlet Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.1PLAT, EDC4
2MP:00053978.8PLAT, EDC4

Publications for Thoracic Outlet Syndrome

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Articles related to Thoracic Outlet Syndrome:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Venous thoracic outlet syndrome. (25832605)
2015
2
"Clavicular Duplication Causing Thoracic Outlet Obstruction": Unique Presentation of Unreported Association between Clavicular Duplication and Thoracic Outlet Syndrome. (25364610)
2014
3
Diagnostic value of magnetic resonance imaging in thoracic outlet syndrome. (25163962)
2014
4
Critical hand ischemia caused by true arterial thoracic outlet syndrome. (24356476)
2014
5
Simultaneous bilateral magnetic resonance angiography to evaluate thoracic outlet syndrome. (25348136)
2014
6
Surgical management of vascular thoracic outlet syndrome: a teaching hospital experience. (23641288)
2013
7
Venous thoracic outlet syndrome caused by a congenital rib malformation. (22544354)
2012
8
Chronic thromboembolic pulmonary hypertension due to upper-extremity deep vein thrombosis caused by thoracic outlet syndrome. (22138476)
2012
9
A possible relationship between reliability of thoracic outlet syndrome diagnostic testing and the position of the axillary artery. (22407179)
2012
10
Thoracic outlet syndrome caused by pseudoarticulation of a cervical rib with the scalene tubercle of the first rib. (22542345)
2012
11
Thoracic outlet syndrome with involvement of the cervical sympathetics because of idiopathic tumoral calcinosis. (21389840)
2011
12
Combined endovascular and open surgical approach for the management of subclavian artery occlusion due to thoracic outlet syndrome. (21585538)
2011
13
First rib resection using videothorascopy for the treatment of thoracic outlet syndrome. (21440976)
2011
14
Surgical treatment of thoracic outlet syndrome in young adults: single centre experience with minimum three-year follow-up. (21184222)
2011
15
Thoracic outlet syndrome: a primer on objective methods of diagnosis. (20599328)
2010
16
MR imaging findings in brachial plexopathy with thoracic outlet syndrome. (19815618)
2010
17
Thoracic outlet syndrome due to an axillary band: what if it ruptures? (20013268)
2010
18
Sonographically guided anesthetic injection of anterior scalene muscle for investigation of neurogenic thoracic outlet syndrome. (19440705)
2009
19
Clavicular nonunion associated with thoracic outlet syndrome treated with Knowles pin fixation, autogenous bone marrow graft, and autologous fibrin clots. (19088549)
2009
20
Thoracic outlet syndrome associated with a large cervical rib. (19556226)
2009
21
Sonographic evaluation of the subclavian artery during thoracic outlet syndrome shoulder manoeuvres. (17928256)
2009
22
Swimmer's CT Angiography of Thoracic Outlet Syndrome. A Case Report. (24256834)
2008
23
A rare cause of thoracic outlet syndrome. (17522878)
2008
24
Thoracic outlet syndrome. (18447701)
2008
25
Medial antebrachial cutaneous nerve measurements to diagnose neurogenic thoracic outlet syndrome. (18346579)
2008
26
Critical review of pathophysiologic mechanisms in thoracic outlet syndrome (TOS). (17985563)
2007
27
Unusual etiology of upper extremity ischemia in a scleroderma patient: thoracic outlet syndrome with arterial embolization. (17543693)
2007
28
Thoracic outlet syndrome portending Klippel-Feil syndrome. (16650793)
2006
29
Long cervical costae articulating with the first ribs: a salient case of thoracic outlet syndrome. (16357555)
2006
30
Thoracic outlet syndrome in a competitive baseball player secondary to the anomalous insertion of an atrophic pectoralis minor muscle: a case report. (16476910)
2006
31
Thoracic outlet syndrome. (15918618)
2005
32
Successful use of Shakuyaku-kanzo-to, a traditional herbal medicine, for intractable symptoms of thoracic outlet syndrome: a case report. (15875134)
2005
33
Surgical treatment of thoracic outlet syndrome: a randomized trial comparing two operations. (16302629)
2005
34
Conservative treatment for thoracic outlet syndrome. (15005383)
2004
35
Neurogenic thoracic outlet syndrome. (12820756)
2003
36
Thoracic outlet syndrome. (12407366)
2002
37
Late thoracic outlet syndrome secondary to malunion of the fractured clavicle: case report and review of the literature. (11901352)
2002
38
Neurogenic thoracic outlet syndrome in whiplash injury. (11723397)
2001
39
Bilateral venous thoracic outlet syndrome in a haemodialysis patient with long-standing body building activities. (11239049)
2001
40
Superior thoracic outlet syndrome. (11569028)
2000
41
CT angiography of thoracic outlet syndrome: evaluation of imaging protocols for the detection of arterial stenosis. (10864068)
2000
42
Thoracic outlet syndrome is overdiagnosed. (9883870)
1999
43
Medial antebrachial cutaneous sensory studies in the evaluation of neurogenic thoracic outlet syndrome. (9572246)
1998
44
Dermatomal and mixed nerve somatosensory evoked potentials in the diagnosis of neurogenic thoracic outlet syndrome. (9780011)
1998
45
Focal hand dystonia in a patient with thoracic outlet syndrome. (9703190)
1998
46
Surgical decompression of thoracic outlet syndrome; is it a worthwhile procedure? (9354065)
1997
47
Palpatory diagnosis and manipulative management of carpal tunnel syndrome: Part 2. 'Double crush' and thoracic outlet syndrome. (7673008)
1995
48
The Vannini-Rizzoli orthosis: a unique case of thoracic outlet syndrome. (8466429)
1993
49
Local thrombolysis and percutaneous transluminal venoplasty for the venous complications of thoracic outlet syndrome: case report. (1443770)
1992
50
Thoracic outlet syndrome: evaluation of the subclavian vessels by color duplex sonography. (1739007)
1992

Variations for Thoracic Outlet Syndrome

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Expression for genes affiliated with Thoracic Outlet Syndrome

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Search GEO for disease gene expression data for Thoracic Outlet Syndrome.

Pathways for genes affiliated with Thoracic Outlet Syndrome

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Compounds for genes affiliated with Thoracic Outlet Syndrome

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GO Terms for genes affiliated with Thoracic Outlet Syndrome

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Products for genes affiliated with Thoracic Outlet Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Thoracic Outlet Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet