TOS
MCID: THR013
MIFTS: 54

Thoracic Outlet Syndrome (TOS) malady

Summaries for Thoracic Outlet Syndrome

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Sources:
42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Thoracic outlet syndrome (tos) causes pain in the arm, shoulder, and neck. it happens when the nerves or blood vessels just below your neck are compressed, or squeezed. the compression can happen between the muscles of your neck and shoulder or between the first rib and collarbone. you may feel burning, tingling, and numbness along your arm, hand, and fingers. if a nerve is compressed, you may also feel weakness in your hand. if a vein is compressed, your hand might be sensitive to cold, or turn pale or bluish. your arm might swell and tire easily. tos is more common in women. it usually starts between 20 and 50 years of age. doctors do nerve and imaging studies to diagnose it. there are many causes of tos, including injury anatomical defects tumors that press on nerves poor posture that causes nerve compression pregnancy repetitive arm and shoulder movements and activity, such as from playing certain sports treatment depends on what caused your tos. medicines, physical therapy, and relaxation might help. surgery may also be an option. most people recover. nih: national institute of neurological disorders and stroke

MalaCards: Thoracic Outlet Syndrome, also known as TOS, is related to ulnar neuropathy and synostosis, and has symptoms including abnormal emg/electromyogram/electropmyography, contractures/cramps/trismus/tetania/claudication/opisthotonos and sensitive trouble/deficit. An important gene associated with Thoracic Outlet Syndrome is PNP (purine nucleoside phosphorylase). The compounds aspartate and glutamate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, testes and bone, and related mouse phenotypes are renal/urinary system and skeleton.

NIH Rare Diseases:42 Thoracic outlet syndrome (tos) describes a group of conditions that are characterized by compression of the nerves, arteries, and veins in the lower neck and upper chest area. this can result in pain in the arms, shoulders, and neck. currently, there is considerable disagreement about its diagnosis and treatment. a number of disorders have symptoms similar to those of tos, including rotator cuff injuries, fibromyalgia, multiple sclerosis, complex regional pain syndrome, and tumors of the syrinx or spinal cord. symptoms of this condition vary depending on the type. the different types include neurogenic, venous, and arterial thoracic outlet syndrome. there are many different causes of toc. symptoms usually occur between 20 and 50 years of age. last updated: 1/26/2012

NINDS:43 TOS is an umbrella term that encompasses three related syndromes that involve compression of the nerves, arteries, and veins in the lower neck and upper chest area and cause pain in the arm, shoulder, and neck.

Wikipedia:63 Thoracic outlet syndrome (TOS) is a syndrome involving compression at the superior thoracic outlet... more...

Aliases & Classifications for Thoracic Outlet Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:



Aliases & Descriptions:

thoracic outlet syndrome 8 42 43 10 48 33 60
tos 42 48
thoracic outlet compression syndrome 48
tos - thoracic outlet syndrome 8


External Ids:

Disease Ontology8 DOID:3103
MeSH34 D013901
NCIt39 C85188
MESH via Orphanet35 D013901
ICD10 via Orphanet26 G54.0
SNOMED-CT via Orphanet57 128210009
UMLS via Orphanet61 C0039984

Related Diseases for Thoracic Outlet Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Thoracic Outlet Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 7301)
idRelated DiseaseScoreTop Affiliating Genes
1ulnar neuropathy30.1EDC4
2synostosis30.0NCOA1
3hepatitis11.1
4leukemia11.0
5prostatitis11.0
6neuronitis10.9
7thyroiditis10.9
8arthritis10.9
9pancreatitis10.9
10melanoma10.9
11lung cancer10.9
12prostate cancer10.9
13adenocarcinoma10.9
14acute leukemia10.8
15hepatitis c10.8
16retinitis10.8
17rheumatoid arthritis10.8
18diabetes mellitus10.8
19tuberculosis10.8
20cervicitis10.8
21colorectal cancer10.8
22squamous cell carcinoma10.8
23hepatitis a10.8
24dermatitis10.8
25alzheimer's disease10.8
26asthma10.8
27esophagitis10.7
28ovarian cancer10.7
29hepatocellular carcinoma10.7
30myocardial infarction10.7
31myeloid leukemia10.7
32influenza10.7
33pneumonia10.7
34multiple sclerosis10.7
35lupus erythematosus10.7
36schizophrenia10.7
37adenoma10.7
38hepatitis b10.7
39sarcoma10.7
40colon cancer10.7
41meningitis10.7
42encephalitis10.7
43neuroblastoma10.7
44systemic lupus erythematosus10.7
45atherosclerosis10.7
46malaria10.7
47dementia10.7
48myeloma10.7
49renal cell carcinoma10.7
50parkinson's disease10.6

Graphical network of the top 20 diseases related to Thoracic Outlet Syndrome:



Diseases related to thoracic outlet syndrome

Clinical Features for Thoracic Outlet Syndrome

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Sources:
48Orphanet
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Symptoms:

48 (show all 14)
  • abnormal emg/electromyogram/electropmyography
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • sensitive trouble/deficit
  • motor deficit/trouble
  • acute ischemic syndrome
  • anomalies of the ribs
  • cutaneous edema
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • muscle weakness/flaccidity
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • venous thrombosis/phlebitis/thrombophlebitis
  • varices/varicous veins/venous insufficiency
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness

Drugs & Therapeutics for Thoracic Outlet Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Thoracic Outlet Syndrome

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Anatomical Context for Thoracic Outlet Syndrome

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32MalaCards
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MalaCards organs/tissues related to Thoracic Outlet Syndrome:

32
Spinal cord, Testes, Bone, Appendix, Bone marrow, Breast

Animal Models for Thoracic Outlet Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thoracic Outlet Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9PNP, KIAA1217, NCOA1, FMN1
2MP:00053908.0HHAT, KIAA1217, PLAT, NCOA1, FMN1
3MP:00107686.9FMN1, EDC4, SYMPK, PLAT, KIAA1217, PNP

Publications for Thoracic Outlet Syndrome

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50PubMed
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Articles related to Thoracic Outlet Syndrome:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Teaching neuroimages: swollen T1 nerve root in neurogenic thoracic outlet syndrome. (23733557)
2013
2
Cognitive and Affective Uses of a Thoracic Outlet Syndrome Facebook Support Group. (24171492)
2013
3
Neurogenic thoracic outlet syndrome associated with cervical rib. (24141346)
2013
4
Bilateral thoracic outlet syndrome: An uncommon presentation of a rare condition in children. (23349606)
2012
5
Pulse oximetry measurements in the evaluation of patients with possible thoracic outlet syndrome. (23174071)
2012
6
Impact of anterior scalene lidocaine blocks on predicting surgical success in older patients with neurogenic thoracic outlet syndrome. (22459745)
2012
7
Thoracic outlet syndrome with involvement of the cervical sympathetics because of idiopathic tumoral calcinosis. (21389840)
2011
8
First rib resection using videothorascopy for the treatment of thoracic outlet syndrome. (21440976)
2011
9
Surgical treatment of thoracic outlet syndrome in young adults: single centre experience with minimum three-year follow-up. (21184222)
2011
10
Isolated cervical rib fracture: a rare etiology of thoracic outlet syndrome. (22606572)
2011
11
Contemporary management of thoracic outlet syndrome. (20838336)
2010
12
Pseudarthrosis of cervical rib: an unusual cause of thoracic outlet syndrome. (21074954)
2010
13
Sonographically guided anesthetic injection of anterior scalene muscle for investigation of neurogenic thoracic outlet syndrome. (19440705)
2009
14
Extensive arterial embolus in the arm of a college runner with thoracic outlet syndrome: a case report. (19638831)
2009
15
Thoracic outlet syndrome: do we have clinical tests as predictors for the outcome after surgery? (19748851)
2009
16
Bilateral functional thoracic outlet syndrome in a collegiate football player. (21509101)
2009
17
Etiological factors in thoracic outlet syndrome. (17598483)
2007
18
Reported in-hospital complications following rib resections for neurogenic thoracic outlet syndrome. (17583473)
2007
19
Unusual case of thoracic outlet syndrome caused by a neurilemmoma in the pectoralis minor space. (16035713)
2005
20
Role of first rib stump length in recurrent neurogenic thoracic outlet syndrome. (15972191)
2005
21
Combination treatment of venous thoracic outlet syndrome: open surgical decompression and intraoperative angioplasty. (15472583)
2004
22
Combined surgical treatment of thoracic outlet syndrome: transaxillary first rib resection and transcervical scalenectomy. (15005387)
2004
23
A novel finding in thoracic outlet syndrome: tachycardia. (15474397)
2004
24
Venous thoracic outlet syndrome secondary to congenital pseudoarthrosis of the clavicle. Presentation in the fourth decade of life. (12787706)
2003
25
SIR 2003 film panel case 7: arterial thoracic outlet syndrome presenting with upper extremity emboli and posterior circulation stroke. (12817052)
2003
26
Transaxillary approach in thoracic outlet syndrome: the importance of resection of the first-rib. (12965316)
2003
27
BIPAP for management of hypoxemia associated with unilateral phrenic nerve palsy following surgery for thoracic outlet syndrome. (12138518)
2002
28
Three-dimensional CT of thoracic outlet syndrome: report of three cases. (11916443)
2002
29
Late thoracic outlet syndrome secondary to malunion of the fractured clavicle: case report and review of the literature. (11242301)
2001
30
Helical CT angiography of thoracic outlet syndrome: functional anatomy. (10845503)
2000
31
Thoracic outlet syndrome: a review of the literature. (10709553)
1999
32
Vascular manifestations of the thoracic outlet syndrome. (9671236)
1998
33
A comparison of surgery for neurogenic thoracic outlet syndrome between laborers and nonlaborers. (9737636)
1998
34
Venous thoracic outlet syndrome simulating subclavian stenosis in a hemodialysis patient. (9845838)
1998
35
Operative treatment of thoracic outlet syndrome in Finland. (8739935)
1996
36
Thoracic outlet syndrome. (8953290)
1996
37
770 consecutive supraclavicular first rib resections for thoracic outlet syndrome. (8905065)
1996
38
Palpatory diagnosis and manipulative management of carpal tunnel syndrome: Part 2. 'Double crush' and thoracic outlet syndrome. (7673008)
1995
39
Congenital clavicular pseudoarthrosis associated with vascular thoracic outlet syndrome: case presentation and review of the literature. (7497504)
1995
40
Somatoform disorders in non-specific neurogenic thoracic outlet syndrome patients. (8848944)
1995
41
Transaxillary first rib resection for thoracic outlet syndrome: follow-up of 9 cases. (8708437)
1995
42
Congenital cervical bands in thoracic outlet syndrome. (7485748)
1995
43
Cardiovascular functional disorder and distress among patients with thoracic outlet syndrome. (7759929)
1995
44
Predicting outcomes in thoracic outlet syndrome. (7715513)
1995
45
Therapist management of thoracic outlet syndrome. (8038876)
1994
46
Thoracic outlet syndrome. (8067821)
1994
47
Thoracic outlet syndrome--a myofascial variant: Part 3. Structural and postural considerations. (8514533)
1993
48
Thoracic outlet syndrome: a case for routine preoperative neurophysiological testing. (1994220)
1991
49
Thoracic outlet syndrome caused by tumor of the first rib. (1861336)
1991
50
Thoracic outlet syndrome--a myofascial variant: Part 1. Pathology and diagnosis. (2204613)
1990

Genetic Variations for Thoracic Outlet Syndrome

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Expression for genes affiliated with Thoracic Outlet Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thoracic Outlet Syndrome

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Pathways for genes affiliated with Thoracic Outlet Syndrome

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Compounds for genes affiliated with Thoracic Outlet Syndrome

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44Novoseek
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Compounds related to Thoracic Outlet Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aspartate449.2PNP, SKAP2, PLAT
2glutamate448.8PNP, PLAT, NCOA1, FMN1

GO Terms for genes affiliated with Thoracic Outlet Syndrome

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Products for genes affiliated with Thoracic Outlet Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thoracic Outlet Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet