TOS
MCID: THR013
MIFTS: 53

Thoracic Outlet Syndrome (TOS) malady

Summaries for Thoracic Outlet Syndrome

Sources:
43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Thoracic outlet syndrome (tos) causes pain in the arm, shoulder, and neck. it happens when the nerves or blood vessels just below your neck are compressed, or squeezed. the compression can happen between the muscles of your neck and shoulder or between the first rib and collarbone. you may feel burning, tingling, and numbness along your arm, hand, and fingers. if a nerve is compressed, you may also feel weakness in your hand. if a vein is compressed, your hand might be sensitive to cold, or turn pale or bluish. your arm might swell and tire easily. tos is more common in women. it usually starts between 20 and 50 years of age. doctors do nerve and imaging studies to diagnose it. there are many causes of tos, including injury anatomical defects tumors that press on nerves poor posture that causes nerve compression pregnancy repetitive arm and shoulder movements and activity, such as from playing certain sports treatment depends on what caused your tos. medicines, physical therapy, and relaxation might help. surgery may also be an option. most people recover. nih: national institute of neurological disorders and stroke

MalaCards: Thoracic Outlet Syndrome, also known as TOS, is related to ulnar neuropathy and synostosis, and has symptoms including motor deficit/trouble, muscle weakness/flaccidity and contractures/cramps/trismus/tetania/claudication/opisthotonos. An important gene associated with Thoracic Outlet Syndrome is PNP (purine nucleoside phosphorylase). The compounds aspartate and glutamate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and skeletal muscle, and related mouse phenotypes are renal/urinary system and skeleton.

NIH Rare Diseases:43 Thoracic outlet syndrome (tos) describes a group of conditions that are characterized by compression of the nerves, arteries, and veins in the lower neck and upper chest area. this can result in pain in the arms, shoulders, and neck. currently, there is considerable disagreement about its diagnosis and treatment. a number of disorders have symptoms similar to those of tos, including rotator cuff injuries, fibromyalgia, multiple sclerosis, complex regional pain syndrome, and tumors of the syrinx or spinal cord. symptoms of this condition vary depending on the type. the different types include neurogenic, venous, and arterial thoracic outlet syndrome. there are many different causes of toc. symptoms usually occur between 20 and 50 years of age. last updated: 1/26/2012

NINDS:44 TOS is an umbrella term that encompasses three related syndromes that involve compression of the nerves, arteries, and veins in the lower neck and upper chest area and cause pain in the arm, shoulder, and neck.

Wikipedia:64 Thoracic outlet syndrome (TOS) is a syndrome involving compression at the superior thoracic outlet... more...

Aliases & Classifications for Thoracic Outlet Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 10DISEASES, 49Orphanet, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:



Aliases & Descriptions:

thoracic outlet syndrome 8 43 44 10 49 34 61
tos 43 49
thoracic outlet compression syndrome 49
tos - thoracic outlet syndrome 8


External Ids:

Disease Ontology8 DOID:3103
MeSH35 D013901
NCIt40 C85188
MESH via Orphanet36 D013901
ICD10 via Orphanet26 G54.0
SNOMED-CT via Orphanet58 128210009
UMLS via Orphanet62 C0039984

Related Diseases for Thoracic Outlet Syndrome

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Thoracic Outlet Syndrome:



Diseases related to thoracic outlet syndrome

Clinical Features for Thoracic Outlet Syndrome

Sources:
49Orphanet
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Symptoms:

49 (show all 14)
  • motor deficit/trouble
  • muscle weakness/flaccidity
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • articular/joint pain/arthralgia
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • abnormal emg/electromyogram/electropmyography
  • cutaneous edema
  • sensitive trouble/deficit
  • anomalies of the ribs
  • myalgia/muscular pain
  • venous thrombosis/phlebitis/thrombophlebitis
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • varices/varicous veins/venous insufficiency
  • acute ischemic syndrome

Drugs & Therapeutics for Thoracic Outlet Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Thoracic Outlet Syndrome

Search NIH Clinical Center for Thoracic Outlet Syndrome

Search CenterWatch for Thoracic Outlet Syndrome

Genetic Tests for Thoracic Outlet Syndrome

Anatomical Context for Thoracic Outlet Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Thoracic Outlet Syndrome:

33
Spinal cord, Bone marrow, Skeletal muscle, Breast, Dorsal root ganglion, Appendix

Animal Models for Thoracic Outlet Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Thoracic Outlet Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9PNP, KIAA1217, NCOA1, FMN1
2MP:00053908.0HHAT, KIAA1217, PLAT, NCOA1, FMN1
3MP:00107686.9FMN1, EDC4, SYMPK, PLAT, KIAA1217, PNP

Publications for Thoracic Outlet Syndrome

Sources:
51PubMed
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Articles related to Thoracic Outlet Syndrome:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Osteoid osteoma of the rib presenting as thoracic outlet syndrome. (24296190)
2013
2
Early effectiveness of isolated pectoralis minor tenotomy in selected patients with neurogenic thoracic outlet syndrome. (23375605)
2013
3
High-definition video-assisted transaxillary first rib resection for thoracic outlet syndrome. (23357519)
2013
4
A possible relationship between reliability of thoracic outlet syndrome diagnostic testing and the position of the axillary artery. (22407179)
2012
5
Modernizing the treatment of venous thoracic outlet syndrome. (22661614)
2012
6
Challenges in the treatment of thoracic outlet syndrome. (23304029)
2012
7
Association of disturbances in the thoracic outlet in subjects with carpal tunnel syndrome: a case-control study. (21272763)
2011
8
Updated perspectives on neurogenic thoracic outlet syndrome. (21104206)
2011
9
The efficacy of scalene injection in thoracic outlet syndrome. (21892402)
2011
10
Thoracic outlet syndrome: a primer on objective methods of diagnosis. (20599328)
2010
11
Thoracic outlet syndrome: a controversial clinical condition. Part 1: anatomy, and clinical examination/diagnosis. (21655389)
2010
12
Clavicle pseudarthrosis: a rare cause of thoracic outlet syndrome. (21059553)
2010
13
Thoracic outlet syndrome. (20129515)
2010
14
Supernumerary subclavius muscle in Thais: predisposing cause of thoracic outlet syndrome. (20873079)
2010
15
Thoracic outlet syndrome secondary to localized scleroderma treated with botulinum toxin injection. (20391491)
2010
16
Thoracic outlet syndrome: a controversial clinical condition. Part 2: non-surgical and surgical management. (21886423)
2010
17
Surgical intervention for thoracic outlet syndrome improves patient's quality of life. (19147319)
2009
18
Thoracic outlet syndrome: a review. (19008742)
2008
19
Histopathological basis for neurogenic thoracic outlet syndrome. Laboratory investigation. (18377320)
2008
20
Unusual etiology of upper extremity ischemia in a scleroderma patient: thoracic outlet syndrome with arterial embolization. (17543693)
2007
21
Imaging assessment of thoracic outlet syndrome. (17102047)
2006
22
Symptoms of thoracic outlet syndrome in women with carpal tunnel syndrome. (16495146)
2006
23
Doppler Adson's test: predictor of outcome of surgery in non-specific thoracic outlet syndrome. (16479352)
2006
24
Thoracic outlet syndrome secondary to first rib anomaly: the value of multi-slice CT in diagnosis and surgical planning. (16255121)
2005
25
Klippel-Feil syndrome presenting with bilateral thoracic outlet syndrome. (15959383)
2005
26
Thoracic outlet syndrome. (15977087)
2005
27
History of thoracic outlet syndrome. (15005378)
2004
28
Epineurectomy for thoracic outlet syndrome. (15005388)
2004
29
Thoracic outlet syndrome surgery: long-term functional results. (15534735)
2004
30
Evaluation of MR angiographic technique in the assessment of thoracic outlet syndrome. (15208064)
2004
31
Neurovascular compression by a subpectoral lipoma. A case report of a rare cause of thoracic outlet syndrome. (14653045)
2003
32
Spinal accessory neuropathy, droopy shoulder, and thoracic outlet syndrome. (12929202)
2003
33
Thoracic outlet syndrome--aspects of diagnosis in the differential diagnosis of hand-arm vibration syndrome. (12890833)
2003
34
Outcomes after surgery for thoracic outlet syndrome. (11389421)
2001
35
Superior thoracic outlet syndrome. (11569028)
2000
36
Outcome of surgery for thoracic outlet syndrome in Washington state workers' compensation. (10746594)
2000
37
Thoracic outlet syndrome is overdiagnosed. (9883870)
1999
38
Thoracic outlet syndrome is underdiagnosed. (9883869)
1999
39
Thoracic Outlet Syndrome: Follow-up on 33 Cases with Regard to Vascular Compression (9585450)
1998
40
Desmoid tumour of the thoracic outlet: an unusual cause of thoracic outlet syndrome. (9793510)
1998
41
Bilateral rudimentary first ribs as a cause of thoracic outlet syndrome. (9002419)
1997
42
Thoracic outlet syndrome reconsidered. (8600849)
1996
43
Diagnosis of thoracic outlet syndrome in the emergency department. (8790325)
1996
44
Thoracic outlet syndrome in children. (8784709)
1996
45
Diagnosis of thoracic outlet syndrome in the emergency department. (8578353)
1996
46
Arterial injuries in the thoracic outlet syndrome. (7823362)
1995
47
Long-term outcome after transaxillary approach for thoracic outlet syndrome. (7482271)
1995
48
Results of upper plexus thoracic outlet syndrome operation. (8067849)
1994
49
Thoracic outlet syndrome. (8503212)
1993
50
Double-crush nerve compression in thoracic-outlet syndrome. (2013609)
1991

Genetic Variations for Thoracic Outlet Syndrome

Expression for genes affiliated with Thoracic Outlet Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thoracic Outlet Syndrome

Search GEO for disease gene expression data for Thoracic Outlet Syndrome.

Pathways for genes affiliated with Thoracic Outlet Syndrome

Compounds for genes affiliated with Thoracic Outlet Syndrome

Sources:
45Novoseek
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Compounds related to Thoracic Outlet Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aspartate459.2PNP, SKAP2, PLAT
2glutamate458.8PNP, PLAT, NCOA1, FMN1

GO Terms for genes affiliated with Thoracic Outlet Syndrome

Products for genes affiliated with Thoracic Outlet Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thoracic Outlet Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet