TOS
MCID: THR013
MIFTS: 54

Thoracic Outlet Syndrome (TOS) malady

Summaries for Thoracic Outlet Syndrome

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Sources:
42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Thoracic outlet syndrome (tos) causes pain in the arm, shoulder, and neck. it happens when the nerves or blood vessels just below your neck are compressed, or squeezed. the compression can happen between the muscles of your neck and shoulder or between the first rib and collarbone. you may feel burning, tingling, and numbness along your arm, hand, and fingers. if a nerve is compressed, you may also feel weakness in your hand. if a vein is compressed, your hand might be sensitive to cold, or turn pale or bluish. your arm might swell and tire easily. tos is more common in women. it usually starts between 20 and 50 years of age. doctors do nerve and imaging studies to diagnose it. there are many causes of tos, including injury anatomical defects tumors that press on nerves poor posture that causes nerve compression pregnancy repetitive arm and shoulder movements and activity, such as from playing certain sports treatment depends on what caused your tos. medicines, physical therapy, and relaxation might help. surgery may also be an option. most people recover. nih: national institute of neurological disorders and stroke

MalaCards: Thoracic Outlet Syndrome, also known as TOS, is related to ulnar neuropathy and synostosis, and has symptoms including acute ischemic syndrome, varices/varicous veins/venous insufficiency and paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness. An important gene associated with Thoracic Outlet Syndrome is PNP (purine nucleoside phosphorylase). The compounds aspartate and glutamate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, testes and bone, and related mouse phenotypes are renal/urinary system and skeleton.

NIH Rare Diseases:42 Thoracic outlet syndrome (tos) describes a group of conditions that are characterized by compression of the nerves, arteries, and veins in the lower neck and upper chest area. this can result in pain in the arms, shoulders, and neck. currently, there is considerable disagreement about its diagnosis and treatment. a number of disorders have symptoms similar to those of tos, including rotator cuff injuries, fibromyalgia, multiple sclerosis, complex regional pain syndrome, and tumors of the syrinx or spinal cord. symptoms of this condition vary depending on the type. the different types include neurogenic, venous, and arterial thoracic outlet syndrome. there are many different causes of toc. symptoms usually occur between 20 and 50 years of age. last updated: 1/26/2012

NINDS:43 TOS is an umbrella term that encompasses three related syndromes that involve compression of the nerves, arteries, and veins in the lower neck and upper chest area and cause pain in the arm, shoulder, and neck.

Wikipedia:63 Thoracic outlet syndrome (TOS) is a syndrome involving compression at the superior thoracic outlet... more...

Aliases & Classifications for Thoracic Outlet Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:



Aliases & Descriptions:

thoracic outlet syndrome 8 42 43 10 48 33 60
tos 42 48
thoracic outlet compression syndrome 48
tos - thoracic outlet syndrome 8


External Ids:

Disease Ontology8 DOID:3103
MeSH34 D013901
NCIt39 C85188
MESH via Orphanet35 D013901
ICD10 via Orphanet26 G54.0
SNOMED-CT via Orphanet57 128210009
UMLS via Orphanet61 C0039984

Related Diseases for Thoracic Outlet Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Thoracic Outlet Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 7301)
idRelated DiseaseScoreTop Affiliating Genes
1ulnar neuropathy30.1EDC4
2synostosis30.0NCOA1
3hepatitis11.1
4leukemia11.0
5prostatitis11.0
6neuronitis10.9
7thyroiditis10.9
8arthritis10.9
9pancreatitis10.9
10melanoma10.9
11lung cancer10.9
12prostate cancer10.9
13adenocarcinoma10.9
14acute leukemia10.8
15hepatitis c10.8
16retinitis10.8
17rheumatoid arthritis10.8
18diabetes mellitus10.8
19tuberculosis10.8
20cervicitis10.8
21colorectal cancer10.8
22squamous cell carcinoma10.8
23hepatitis a10.8
24dermatitis10.8
25alzheimer's disease10.8
26asthma10.8
27esophagitis10.7
28ovarian cancer10.7
29hepatocellular carcinoma10.7
30myocardial infarction10.7
31myeloid leukemia10.7
32influenza10.7
33pneumonia10.7
34multiple sclerosis10.7
35lupus erythematosus10.7
36schizophrenia10.7
37adenoma10.7
38hepatitis b10.7
39sarcoma10.7
40colon cancer10.7
41meningitis10.7
42encephalitis10.7
43neuroblastoma10.7
44systemic lupus erythematosus10.7
45atherosclerosis10.7
46malaria10.7
47dementia10.7
48myeloma10.7
49renal cell carcinoma10.7
50parkinson's disease10.6

Graphical network of the top 20 diseases related to Thoracic Outlet Syndrome:



Diseases related to thoracic outlet syndrome

Clinical Features for Thoracic Outlet Syndrome

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48Orphanet
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Symptoms:

48 (show all 14)
  • acute ischemic syndrome
  • varices/varicous veins/venous insufficiency
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • venous thrombosis/phlebitis/thrombophlebitis
  • myalgia/muscular pain
  • muscle weakness/flaccidity
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • articular/joint pain/arthralgia
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • abnormal emg/electromyogram/electropmyography
  • cutaneous edema
  • sensitive trouble/deficit
  • anomalies of the ribs
  • motor deficit/trouble

Drugs & Therapeutics for Thoracic Outlet Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Thoracic Outlet Syndrome

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Anatomical Context for Thoracic Outlet Syndrome

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32MalaCards
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MalaCards organs/tissues related to Thoracic Outlet Syndrome:

32
Spinal cord, Testes, Bone, Appendix, Bone marrow, Breast

Animal Models for Thoracic Outlet Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thoracic Outlet Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9PNP, KIAA1217, NCOA1, FMN1
2MP:00053908.0HHAT, KIAA1217, PLAT, NCOA1, FMN1
3MP:00107686.9FMN1, EDC4, SYMPK, PLAT, KIAA1217, PNP

Publications for Thoracic Outlet Syndrome

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50PubMed
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Articles related to Thoracic Outlet Syndrome:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Critical hand ischemia caused by true arterial thoracic outlet syndrome. (24356476)
2014
2
Sonographic diagnosis of true neurogenic thoracic outlet syndrome. (24276334)
2013
3
Descriptive anatomy of the interscalene triangle and the costoclavicular space and their relationship to thoracic outlet syndrome: a study of 60 cadavers. (22608284)
2012
4
A case of traumatic thoracic outlet syndrome. (23275926)
2012
5
Thoracic outlet syndrome. (21824588)
2011
6
Fibrotendinous band causing neurogenic Thoracic Outlet Syndrome in adolescent with bilateral cervical ribs. (21955973)
2011
7
Venous complications of thoracic outlet syndrome. (22041832)
2011
8
Thoracic outlet syndrome due to an axillary band: what if it ruptures? (20013268)
2010
9
Endoscopic transaxillary first rib resection for thoracic outlet syndrome: a safe surgical option. (20226128)
2010
10
A case of thoracic outlet syndrome in pregnancy. (20604663)
2010
11
Thoracic outlet syndrome after contralateral-sided mastectomy in a patient with breast cancer. (20698391)
2010
12
Progredient neurogenic and vascular thoracic outlet syndrome due to bilateral cervical ribs. (20172181)
2010
13
Diagnosis and management of thoracic outlet syndrome. (19741351)
2009
14
Iatrogenic thoracic outlet syndrome secondary to vertical expandable prosthetic titanium rib expansion thoracoplasty: pathogenesis and strategies for prevention/treatment. (19098642)
2009
15
Thoracic outlet syndrome in children and young adults. (19700352)
2009
16
Swimmer's CT Angiography of Thoracic Outlet Syndrome. A Case Report. (24256834)
2008
17
Thoracic outlet syndrome. (18447701)
2008
18
Two cases and two particular signs of thoracic outlet syndrome: tremor and tachycardia. (18551294)
2008
19
A 17-year-old girl with a small left hand: thoracic outlet syndrome is on the agenda. (17656735)
2008
20
Thoracic outlet syndrome secondary to first rib anomaly: the value of multi-slice CT in diagnosis and surgical planning. (17432817)
2007
21
Thoracic outlet syndrome--24 years of experience. (18306720)
2007
22
Thoracic outlet syndrome portending Klippel-Feil syndrome. (16650793)
2006
23
Transient thoracic duct obstruction in a patient with thoracic outlet syndrome. (16901713)
2006
24
An evidence-based review of magnetic resonance angiography for diagnosing arterial thoracic outlet syndrome. (17056401)
2006
25
Quantification of the weakness and fatigue in thoracic outlet syndrome with isokinetic measurements. (15728700)
2005
26
Venous thoracic outlet syndrome. (15005393)
2004
27
Thoracic outlet syndrome and anaesthetic problems. (14674987)
2004
28
Compression and stretching of the brachial plexus in thoracic outlet syndrome: correlation between neuroradiographic findings and symptoms and signs produced by provocation manoeuvres. (12809651)
2003
29
Neurogenic thoracic outlet syndrome in whiplash injury. (11723397)
2001
30
Thoracic outlet syndrome: case report and review. (18350710)
2001
31
Regarding "Long-term functional outcome of neurogenic thoracic outlet syndrome in surgically and conservatively treated patients". (11668337)
2001
32
Color Doppler and duplex sonography in 5 patients with thoracic outlet syndrome. (11444739)
2001
33
Arterial thoracic outlet syndrome with embolic cerebral infarction. Report of a case. (11294095)
2000
34
Thoracic outlet syndrome: influence of personal history and surgical technique on long-term results. (10456401)
1999
35
Diagnosing upper plexus thoracic outlet syndrome with median motor nerve conduction studies. (10086584)
1999
36
The false-positive rate of thoracic outlet syndrome shoulder maneuvers in healthy subjects. (9562199)
1998
37
Reserving supraclavicular first rib resection for vascular complications of thoracic outlet syndrome. (8795532)
1996
38
You're the flight surgeon. Thoracic outlet syndrome. (8801859)
1996
39
Thoracic outlet syndrome: a current overview. (8672571)
1996
40
Dorsal scapular nerve compression. Atypical thoracic outlet syndrome. (7587488)
1995
41
Transaxillary first rib resection for thoracic outlet syndrome. (7610740)
1995
42
Classic neurogenic thoracic outlet syndrome in a competitive swimmer: a true scalenus anticus syndrome. (7823983)
1995
43
The use of intravascular ultrasound in the management of thoracic outlet syndrome. (8030814)
1994
44
Diagnosis of thoracic outlet syndrome. Relative value of electrophysiological studies. (7847058)
1994
45
Dorsal sympathectomy and management of thoracic outlet syndrome with VATS. (8379779)
1993
46
Consider chiropractic management of thoracic outlet syndrome. (1495600)
1992
47
Severe injuries resulting from operations for thoracic outlet syndrome: can they be avoided? (1939323)
1991
48
Neurilemmoma as a cause of combined thoracic outlet and Horner's syndrome. (1948974)
1991
49
Thoracic outlet syndrome--a myofascial variant: Part 2. Treatment. (2211196)
1990
50
Subclavian artery aneurysm an arterial complication of thoracic outlet syndrome. (1267278)
1976

Genetic Variations for Thoracic Outlet Syndrome

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Expression for genes affiliated with Thoracic Outlet Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thoracic Outlet Syndrome

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Pathways for genes affiliated with Thoracic Outlet Syndrome

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Compounds for genes affiliated with Thoracic Outlet Syndrome

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44Novoseek
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Compounds related to Thoracic Outlet Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aspartate449.2PNP, SKAP2, PLAT
2glutamate448.8PNP, PLAT, NCOA1, FMN1

GO Terms for genes affiliated with Thoracic Outlet Syndrome

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Products for genes affiliated with Thoracic Outlet Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thoracic Outlet Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet