TOS
MCID: THR013
MIFTS: 52

Thoracic Outlet Syndrome (TOS) malady

Rare diseases, Cardiovascular diseases categories

Summaries for Thoracic Outlet Syndrome

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 35MedlinePlus, 45NINDS, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Thoracic outlet syndrome (tos) causes pain in the arm, shoulder, and neck. it happens when the nerves or blood vessels just below your neck are compressed, or squeezed. the compression can happen between the muscles of your neck and shoulder or between the first rib and collarbone. you may feel burning, tingling, and numbness along your arm, hand, and fingers. if a nerve is compressed, you may also feel weakness in your hand. if a vein is compressed, your hand might be sensitive to cold, or turn pale or bluish. your arm might swell and tire easily. tos is more common in women. it usually starts between 20 and 50 years of age. doctors do nerve and imaging studies to diagnose it. there are many causes of tos, including injury anatomical defects tumors that press on nerves poor posture that causes nerve compression pregnancy repetitive arm and shoulder movements and activity, such as from playing certain sports treatment depends on what caused your tos. medicines, physical therapy, and relaxation might help. surgery may also be an option. most people recover. nih: national institute of neurological disorders and stroke

MalaCards: Thoracic Outlet Syndrome, also known as TOS, is related to hepatitis and leukemia, and has symptoms including acute ischemic syndrome, varices/varicous veins/venous insufficiency and paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness. An important gene associated with Thoracic Outlet Syndrome is PLAT (plasminogen activator, tissue). Affiliated tissues include spinal cord, testes and bone, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:9 A vascular disease that is characterized by compression at the superior thoracic outlet[1] resulting from excess pressure placed on a neurovascular bundle passing between the anterior scalene and middle scalene muscles.

NIH Rare Diseases:44 Thoracic outlet syndrome (tos) describes a group of conditions that are characterized by compression of the nerves, arteries, and veins in the lower neck and upper chest area. this can result in pain in the arms, shoulders, and neck. currently, there is considerable disagreement about its diagnosis and treatment. a number of disorders have symptoms similar to those of tos, including rotator cuff injuries, fibromyalgia, multiple sclerosis, complex regional pain syndrome, and tumors of the syrinx or spinal cord. symptoms of this condition vary depending on the type. the different types include neurogenic, venous, and arterial thoracic outlet syndrome. there are many different causes of toc. symptoms usually occur between 20 and 50 years of age. last updated: 1/26/2012

NINDS:45 TOS is an umbrella term that encompasses three related syndromes that involve compression of the nerves, arteries, and veins in the lower neck and upper chest area and cause pain in the arm, shoulder, and neck.

Wikipedia:66 Thoracic outlet syndrome (TOS) is a syndrome involving compression at the superior thoracic outlet... more...

Aliases & Classifications for Thoracic Outlet Syndrome

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9Disease Ontology, 44NIH Rare Diseases, 45NINDS, 11DISEASES, 50Orphanet, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

thoracic outlet syndrome 9 44 45 11 50 35 63
tos 44 50
thoracic outlet compression syndrome 50
tos - thoracic outlet syndrome 9


External Ids:

Disease Ontology9 DOID:3103
MeSH36 D013901
NCIt41 C85188
MESH via Orphanet37 D013901
ICD10 via Orphanet27 G54.0
SNOMED-CT via Orphanet60 128210009
UMLS via Orphanet64 C0039984

Related Diseases for Thoracic Outlet Syndrome

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Thoracic Outlet Syndrome:



Diseases related to thoracic outlet syndrome

Symptoms for Thoracic Outlet Syndrome

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50Orphanet
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Symptoms:

50 (show all 14)
  • acute ischemic syndrome
  • varices/varicous veins/venous insufficiency
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • venous thrombosis/phlebitis/thrombophlebitis
  • myalgia/muscular pain
  • muscle weakness/flaccidity
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • articular/joint pain/arthralgia
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • abnormal emg/electromyogram/electropmyography
  • cutaneous edema
  • sensitive trouble/deficit
  • anomalies of the ribs
  • motor deficit/trouble

Drugs & Therapeutics for Thoracic Outlet Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Thoracic Outlet Syndrome

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Anatomical Context for Thoracic Outlet Syndrome

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34MalaCards
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MalaCards organs/tissues related to Thoracic Outlet Syndrome:

34
Spinal cord, Testes, Bone, Appendix, Bone marrow, Breast

Animal Models for Thoracic Outlet Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Thoracic Outlet Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.1PLAT, EDC4
2MP:00053978.8PLAT, EDC4

Publications for Thoracic Outlet Syndrome

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53PubMed
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Articles related to Thoracic Outlet Syndrome:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Critical hand ischemia caused by true arterial thoracic outlet syndrome. (24356476)
2014
2
Surgical management of vascular thoracic outlet syndrome: a teaching hospital experience. (23641288)
2013
3
Venous thoracic outlet syndrome caused by a congenital rib malformation. (22544354)
2012
4
Chronic thromboembolic pulmonary hypertension due to upper-extremity deep vein thrombosis caused by thoracic outlet syndrome. (22138476)
2012
5
A possible relationship between reliability of thoracic outlet syndrome diagnostic testing and the position of the axillary artery. (22407179)
2012
6
Thoracic outlet syndrome caused by pseudoarticulation of a cervical rib with the scalene tubercle of the first rib. (22542345)
2012
7
Thoracic outlet syndrome with involvement of the cervical sympathetics because of idiopathic tumoral calcinosis. (21389840)
2011
8
Combined endovascular and open surgical approach for the management of subclavian artery occlusion due to thoracic outlet syndrome. (21585538)
2011
9
First rib resection using videothorascopy for the treatment of thoracic outlet syndrome. (21440976)
2011
10
Surgical treatment of thoracic outlet syndrome in young adults: single centre experience with minimum three-year follow-up. (21184222)
2011
11
Thoracic outlet syndrome: a primer on objective methods of diagnosis. (20599328)
2010
12
MR imaging findings in brachial plexopathy with thoracic outlet syndrome. (19815618)
2010
13
Thoracic outlet syndrome due to an axillary band: what if it ruptures? (20013268)
2010
14
Sonographically guided anesthetic injection of anterior scalene muscle for investigation of neurogenic thoracic outlet syndrome. (19440705)
2009
15
Clavicular nonunion associated with thoracic outlet syndrome treated with Knowles pin fixation, autogenous bone marrow graft, and autologous fibrin clots. (19088549)
2009
16
Thoracic outlet syndrome associated with a large cervical rib. (19556226)
2009
17
Sonographic evaluation of the subclavian artery during thoracic outlet syndrome shoulder manoeuvres. (17928256)
2009
18
Swimmer's CT Angiography of Thoracic Outlet Syndrome. A Case Report. (24256834)
2008
19
A rare cause of thoracic outlet syndrome. (17522878)
2008
20
Thoracic outlet syndrome. (18447701)
2008
21
Medial antebrachial cutaneous nerve measurements to diagnose neurogenic thoracic outlet syndrome. (18346579)
2008
22
Critical review of pathophysiologic mechanisms in thoracic outlet syndrome (TOS). (17985563)
2007
23
Unusual etiology of upper extremity ischemia in a scleroderma patient: thoracic outlet syndrome with arterial embolization. (17543693)
2007
24
Thoracic outlet syndrome portending Klippel-Feil syndrome. (16650793)
2006
25
Long cervical costae articulating with the first ribs: a salient case of thoracic outlet syndrome. (16357555)
2006
26
Thoracic outlet syndrome in a competitive baseball player secondary to the anomalous insertion of an atrophic pectoralis minor muscle: a case report. (16476910)
2006
27
Imaging assessment of thoracic outlet syndrome. (17102047)
2006
28
Thoracic outlet syndrome. (15918618)
2005
29
Successful use of Shakuyaku-kanzo-to, a traditional herbal medicine, for intractable symptoms of thoracic outlet syndrome: a case report. (15875134)
2005
30
Surgical treatment of thoracic outlet syndrome: a randomized trial comparing two operations. (16302629)
2005
31
Thoracic outlet syndrome secondary to first rib anomaly: the value of multi-slice CT in diagnosis and surgical planning. (16255121)
2005
32
Conservative treatment for thoracic outlet syndrome. (15005383)
2004
33
Venous thoracic outlet syndrome secondary to congenital pseudoarthrosis of the clavicle. Presentation in the fourth decade of life. (12787706)
2003
34
Thoracic outlet syndrome. (12407366)
2002
35
Late thoracic outlet syndrome secondary to malunion of the fractured clavicle: case report and review of the literature. (11901352)
2002
36
Neurogenic thoracic outlet syndrome in whiplash injury. (11723397)
2001
37
Bilateral venous thoracic outlet syndrome in a haemodialysis patient with long-standing body building activities. (11239049)
2001
38
Superior thoracic outlet syndrome. (11569028)
2000
39
CT angiography of thoracic outlet syndrome: evaluation of imaging protocols for the detection of arterial stenosis. (10864068)
2000
40
Thoracic outlet syndrome is overdiagnosed. (9883870)
1999
41
Medial antebrachial cutaneous sensory studies in the evaluation of neurogenic thoracic outlet syndrome. (9572246)
1998
42
Dermatomal and mixed nerve somatosensory evoked potentials in the diagnosis of neurogenic thoracic outlet syndrome. (9780011)
1998
43
Focal hand dystonia in a patient with thoracic outlet syndrome. (9703190)
1998
44
Surgical decompression of thoracic outlet syndrome; is it a worthwhile procedure? (9354065)
1997
45
Palpatory diagnosis and manipulative management of carpal tunnel syndrome: Part 2. 'Double crush' and thoracic outlet syndrome. (7673008)
1995
46
The Vannini-Rizzoli orthosis: a unique case of thoracic outlet syndrome. (8466429)
1993
47
Local thrombolysis and percutaneous transluminal venoplasty for the venous complications of thoracic outlet syndrome: case report. (1443770)
1992
48
Thoracic outlet syndrome: evaluation of the subclavian vessels by color duplex sonography. (1739007)
1992
49
Thoracic outlet syndrome: a case for routine preoperative neurophysiological testing. (1994220)
1991
50
Subclavian artery aneurysm; sequela of thoracic outlet syndrome. (4854512)
1974

Variations for Thoracic Outlet Syndrome

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Expression for genes affiliated with Thoracic Outlet Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thoracic Outlet Syndrome

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Pathways for genes affiliated with Thoracic Outlet Syndrome

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Compounds for genes affiliated with Thoracic Outlet Syndrome

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GO Terms for genes affiliated with Thoracic Outlet Syndrome

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Products for genes affiliated with Thoracic Outlet Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thoracic Outlet Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet