MCID: THR035
MIFTS: 42

Thrombasthenia malady

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Thrombasthenia

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Aliases & Descriptions for Thrombasthenia:

Name: Thrombasthenia 47 67

Classifications:



Summaries for Thrombasthenia

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MalaCards based summary: Thrombasthenia is related to bernard-soulier syndrome, type c and type 2n von willebrand disease. An important gene associated with Thrombasthenia is ITGA2B (Integrin Subunit Alpha 2b), and among its related pathways are L1CAM interactions and Cell adhesion_Endothelial cell contacts by non-junctional mechanisms. Affiliated tissues include bone, bone marrow and whole blood, and related mouse phenotypes are digestive/alimentary and liver/biliary system.

Related Diseases for Thrombasthenia

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Diseases related to Thrombasthenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1bernard-soulier syndrome, type c30.7F2, GP1BA, GP9, ITGA2, ITGA2B, ITGB3
2type 2n von willebrand disease30.1GP1BA, SELP
3glanzmann thrombasthenia12.5
4thrombasthenia of glanzmann and naegeli, itga2b-related11.8
5thrombasthenia of glanzmann and naegeli, itgb3-related11.8
6bleeding disorder, platelet-type, 16, autosomal dominant11.1
7bleeding disorder, platelet-type, 1711.0
8leukocyte adhesion deficiency, type iii10.8
9leukocyte adhesion deficiency10.8
10schlegelberger grote syndrome10.8
11interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital10.7ITGA2B, ITGB3
12lower urinary tract calculus10.6F2, ITGA2
13rasa1-related disorders10.5F2, MTHFR
14cervical dermoid cyst10.5GP1BA, ITGA2B, ITGB3
15typhoid fever10.5F2, MTHFR
16familial glomangioma10.5F2, F3
17ariboflavinosis10.4F2, F3
18fasciitis10.4F2, ITGA2
19c1 inhibitor deficiency10.4F2, GP1BA, ITGB3
20myiasis10.4F2, F3
21michels caskey syndrome10.4F5, MTHFR
22cavernous hemangioma of face10.4F2, F3
23marek disease10.4F2, F3
24congenital stenosis of the inferior vena cava10.4F5, MTHFR
25hypertensive heart disease10.4F2, MTHFR
26ovarian gonadoblastoma10.4F2, F3
27cerebral angioma10.4F2, F3
28sacrococcygeal teratoma10.4F2, ITGA2, MTHFR
29collagenous colitis10.4F2, F5
30von willibrand disease, type 310.4F2, F3
31ameloblastic carcinoma10.4F5, MTHFR
32brill-zinsser disease10.4F2, F3
33epididymo-orchitis10.3F2, F3
34bartholin's gland adenoma10.3F2, F5
35histoplasmosis10.3F2, MTHFR, SELP
36fetal brain disruption sequence10.3GP1BA, ITGA2, ITGA2B, ITGB3
37psychosexual disorder10.3F2, MTHFR, SELP
38thrombophilia due to thrombin defect10.3F2, F5
39pregnancy loss, recurrent 110.3F5, MTHFR
40factor x deficiency10.3EGF, F2, F3
41colon carcinoma in situ10.3F3, ITGA2B, SELP
42alpha-2-plasmin inhibitor deficiency10.3F2, GP1BA, MTHFR
43scapuloperoneal myopathy, x-linked dominant10.3EGF, F2, F3
44acquired fructose intolerance10.3F3, F5
45atrophic gastritis10.3GP1BA, ITGA2B, ITGB3, SELP
46subcortical arteriosclerotic encephalopathy10.3F2, F5, MTHFR
47thrombocytopenic purpura, autoimmune10.3GP1BA, ITGA2B, ITGB3, SELP
48unicentric castleman disease10.3F2, F5, MTHFR
49thyroid hyalinizing trabecular adenoma10.3F2, F5, MTHFR
50wfs1-related disorders10.2F2, F3, GP1BA

Graphical network of the top 20 diseases related to Thrombasthenia:



Diseases related to thrombasthenia

Symptoms for Thrombasthenia

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Drugs & Therapeutics for Thrombasthenia

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Drugs for Thrombasthenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Mycophenolic acidapprovedPhase 193924280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
 
Melbex
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolsäure
Myfortic
2
AbataceptapprovedPhase 1192332348-12-610237
Synonyms:
CTLA4-Ig
 
CTLA4-IgG4m
CTLA4Ig
CTLA4IgG4m
3
Mycophenolate mofetilapproved, investigationalPhase 1939128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil
4
Cyclosporineapproved, investigational, vet_approvedPhase 191579217-60-0, 59865-13-35284373, 6435893
Synonyms:
1c5f
1cyn
30024_FLUKA
30024_SIGMA
59865-13-3
79217-60-0
AC1L1EQW
AC1NQXJE
AC1NR4C4
AC1NUQK3
AC1NUZNC
AC1O5KOG
AC1Q2UDG
Ambap59865-13-3
Ambotz59865-13-3
Antibiotic S 7481F1
BMT-ABA-SAR-MLE-VAL-MLE-ALA-ALA-MLE-MLE-MVA
BMT-ABA-SAR-MLE-VAL-MLE-ALA-DAL-MLE-MLE-MVA
BPBio1_000496
BRD-A64290322-001-01-6
BRD-A69815203-001-04-3
BRD-K13533483-001-03-0
BSPBio_000450
BSPBio_001596
BSPBio_003186
C 3662
C05086
C1832_SIGMA
C3662_SIGMA
C62H111N11O12
CB-01-09 MMX
CHEBI:106343
CHEBI:328305
CHEBI:4031
CHEMBL160
CHEMBL386389
CHEMBL532318
CID2909
CID5280754
CID5284373
CID5458585
CID5497195
CID6435893
CSA
CYCLOSPORIN A (SEE ALSO TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A))
CYCLOSPORIN A, USP
Ciclosporin
Ciclosporin (JP15)
Ciclosporina
Ciclosporine
Ciclosporinum
Cipol N
Cipol-N
Consupren
Consupren S
CsA
CsA & IFN.alpha.
CyA
Cyclokat
Cyclosporin
Cyclosporin A
Cyclosporin A & IFN.alpha.
Cyclosporin A Implant
Cyclosporin A, Tolypocladium inflatum
Cyclosporine (USP)
Cyclosporine A
Cyclosporine [USAN]
D00184
DE-076
DivK1c_000871
EU-0100242
Equoral
GNF-Pf-2808
Gengraf
Gengraf (TN)
HMS1569G12
HMS1791P18
HMS1921L20
HMS1989P18
HMS2089A09
HMS2092F06
HMS502L13
Helv Chim Acta 60: 1568 (1977)
 
I06-0379
I06-0966
IDI1_000871
KBio1_000871
KBio2_000780
KBio2_003348
KBio2_005916
KBio3_002686
KBioGR_001898
KBioSS_000780
LMPK14000003
LS-257
LS-58836
Lopac0_000242
MLS000028376
MLS001333756
MLS002153454
MLS002207033
Mitogard
Modusik-A
MolPort-000-760-988
MolPort-005-934-008
MolPort-006-705-994
NCGC00093704-01
NCGC00093704-02
NCGC00093704-03
NCGC00093704-04
NCGC00093704-05
NCGC00093704-06
NCGC00093704-07
NCGC00093704-08
NCGC00164258-01
NCGC00164258-02
NINDS_000871
NSC290193
Neoplanta
Neoral
Neoral (TN)
NeuroSTAT
Nova-22007
OL 27-400
OL-27400
OLO-400
Papilock
Prestwick2_000435
Prestwick3_000435
Prestwick_731
Pulminiq
Ramihyphin A
Restasis
Restasis (TN)
S-Neoral
S1514_Selleck
SDZ-OXL 400
SMR000058578
SPBio_001467
SPECTRUM1502202
ST-603
Sandimmun
Sandimmun Neoral
Sandimmune
Sandimmune (TN)
Sandimmune, Gengraf, Restasis, Atopica, Sangcya, Cyclosporine
Sang-2000
Sang-35
SangCyA
Sangcya
Sigmasporin
Sigmasporin Microoral
Spectrum2_001484
Spectrum3_001593
Spectrum4_001279
Spectrum5_001628
Spectrum_000300
TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A)
Vekacia
Zyclorin
cyclophorine
cyclosporin A
cyclosporine
from Tolypocladium inflatum (Trichoderma polysporin)
nchembio.184-comp6
nchembio.301-comp5
nchembio.342-comp1
5Immunosuppressive AgentsPhase 112770
6Antirheumatic AgentsPhase 110627
7Antifibrinolytic Agents459
8Hemostatics1359
9Dermatologic Agents5674

Interventional clinical trials:

idNameStatusNCT IDPhase
1Bioequivalence of NovoSeven® and a NovoSeven® Formulation Stable at Room Temperature in Healthy Male SubjectsCompletedNCT01561417Phase 1
2BMT Abatacept for Non-Malignant DiseasesRecruitingNCT01917708Phase 1
3Evaluation of Menses in Congenital Bleeding DisordersUnknown statusNCT01261936
4Evaluation of a New Approach of the Diagnosis of Constitutional Functional Disorders of PlateletsUnknown statusNCT01957345
5Observational Registry of the Treatment of Glanzmann's ThrombastheniaCompletedNCT01476423
6Observational Study on the Efficacy and Safety of NovoSeven® During "Real-life" Usage in GermanyCompletedNCT00697320
7The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders.RecruitingNCT00230165
8A Study to Evaluate Safety and Efficacy of NovoSeven® in Patients With Glanzmann's Thrombasthenia in JapanActive, not recruitingNCT01876745
9Alefacept and Allogeneic Hematopoietic Stem Cell TransplantationSuspendedNCT01319851

Search NIH Clinical Center for Thrombasthenia

Genetic Tests for Thrombasthenia

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Anatomical Context for Thrombasthenia

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MalaCards organs/tissues related to Thrombasthenia:

35
Bone, Bone marrow, Whole blood, Monocytes, Testes, Endothelial, Myeloid

Animal Models for Thrombasthenia or affiliated genes

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MGI Mouse Phenotypes related to Thrombasthenia:

40 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.0CD36, EGF, F2, ITGA2B, ITGB3, PTK2
2MP:00053708.5CD36, F5, ITGB3, PSMG1, PTK2, SELP
3MP:00053918.4CD36, EGF, F3, ITGB3, MTHFR, SELP
4MP:00028738.3EGF, F2, F3, ITGA2, ITGB3, PSMG1
5MP:00053877.8CD36, EGF, F2, F3, HPSE, ITGA2B
6MP:00036317.4CD36, F2, F3, F5, ITGB3, MTHFR
7MP:00107717.3EGF, F2, F3, F5, HPSE, ITGA2
8MP:00053787.3CD36, EGF, F2, F3, F5, ITGB3
9MP:00053847.2CD36, F3, GP1BA, HPSE, ITGA2, ITGA2B
10MP:00053857.2CD36, F2, F3, F5, HPSE, ITGA2B
11MP:00053767.1CD36, F2, F3, F5, GP1BA, ITGA2
12MP:00053976.8CD36, F2, F3, GP1BA, GP9, HPSE

Publications for Thrombasthenia

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Articles related to Thrombasthenia:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Surgical procedures in patients with Glanzmann's thrombasthenia: case series and literature review. (27273143)
2016
2
Efficacy of tranexamic acid for the prevention of bleeding in patients with von Willebrand disease and Glanzmann thrombasthenia: a controlled, before and after trial. (27478149)
2016
3
Glanzmann thrombasthenia associated with human immunodeficiency virus-positive patient. (24829739)
2014
4
Inherited platelet disorders including Glanzmann thrombasthenia and Bernard-Soulier syndrome. (24319190)
2013
5
Acquired Glanzmann Thrombasthenia Associated With Hodgkin Lymphoma: Rapid Reversal of Functional Platelet Defect With ABVD (Adriamycin/Bleomycin/Vinblastine/Dacarbazine) Chemotherapy. (24342105)
2013
6
A novel ELISA for diagnosis of Glanzmann's thrombasthenia and the heterozygote carriers. (22183252)
2012
7
Intensive menstrual bleeding successfully treated with recombinant factor VIIa in Glanzmann thrombasthenia. (20460355)
2011
8
Are bone defects in rare patients with Glanzmann's thrombasthenia associated with ITGB3 or ITGA2B mutations? (21557682)
2011
9
Formation of obstructing blood clot in the ureter in a patient with Glanzmann's thrombasthenia. (21885955)
2011
10
Glanzmann thrombasthenia detected because of knee hemarthrosis: a case report. (20736850)
2010
11
Modulation of clinical phenotype of Glanzmann's thrombasthenia by thrombogenic mutations. (19245802)
2009
12
Glanzmann thrombasthenia in a neonate. (17277431)
2007
13
Glanzmann's thrombasthenia in two pregnant females. (17013816)
2007
14
Diversity of Glanzmann thrombasthenia in southern India: 10 novel mutations identified among 15 unrelated patients. (16879215)
2006
15
Monitoring survival and function of transfused platelets in Glanzmann thrombasthenia by flow cytometry and thrombelastography. (16907879)
2006
16
A novel homozygous mutation (1619delC) in GPIIb gene associated with Glanzmann thrombasthenia, the decay of GPIIb-mRNA and the synthesis of a truncated GPIIb unable to form complex with GPIIIa. (15886807)
2005
17
Rebuttal: the French Gypsy mutation does not give rise to a particularly mild form of Glazmann's thrombasthenia. (14629489)
2003
18
Gene therapy for platelet disorders: studies with Glanzmann's thrombasthenia. (14629461)
2003
19
A Leu55 to Pro substitution in the integrin alphaIIb is responsible for a case of Glanzmann's thrombasthenia. (12181054)
2002
20
A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia-like phenotype. (11588040)
2001
21
Use of recombinant factor VIIa (NovoSeven) in patients with Glanzmann thrombasthenia. (11735106)
2001
22
Identification of a region in glycoprotein IIIa involved in subunit association with glycoprotein IIb: further lessons from Iraqi-Jewish Glanzmann thrombasthenia. (11493452)
2001
23
Glanzmann thrombasthenia: integrin alpha IIb beta 3 deficiency. (11197210)
2000
24
Mutations in the alphaIIb and beta3 genes that cause Glanzmann thrombasthenia can be distinguished by a simple procedure using transformed B-lymphocytes. (9493569)
1998
25
Illegitimate transcription: its use for studying genetic abnormalities in lymphoblastoid cells from patients with Glanzmann thrombasthenia. (9450787)
1998
26
Norethisterone therapy for bleeding due to gastrointestinal telangiectases in Glanzmann's thrombasthenia. (9504647)
1998
27
GLANZMANN's THROMBASTHENIA-SPECTRUM OF CLINICAL PRESENTATION ON SAUDI PATIENTS IN THE EASTERN PROVINCE. (23008567)
1997
28
A mutant (Arg327-->His) GPIIb associated to thrombasthenia exerts a dominant negative effect in stably transfected CHO cells. (8883261)
1996
29
Hepatic haematoma related to Glanzmann thrombasthenia in a newborn infant. (8616139)
1996
30
Periodontal management of Glanzmann's thrombasthenia: report of 3 cases. (8866321)
1996
31
Thrombasthenia--a rare cause of Sheehan's syndrome. (7604695)
1995
32
Adenine nucleotide binding and photoincorporation in Glanzmann's thrombasthenia platelets. (7794942)
1995
33
Glanzmann's thrombasthenia: the use of autologous fibrin glue in tooth extractions. (7608371)
1995
34
Glanzmann's thrombasthenia with mild von Willebrand's disease. (8282841)
1993
35
Delivery of infants with Glanzmann thrombasthenia and subsequent blood transfusion requirements: a follow-up of 39 patients. (1566741)
1992
36
Antibody removal therapy used successfully at delivery of a pregnant patient with Glanzmann's thrombasthenia and multiple anti-platelet antibodies. (1949709)
1991
37
Thrombasthenia with an abnormal platelet membrane glycoprotein IIb of different molecular weight. (3355897)
1988
38
Limited septoplasty as treatment for recurrent epistaxis in a child with Glanzmann's thrombasthenia. (3821355)
1987
39
Immunologic and biochemical characterization of homozygous and heterozygous Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations of Israel: comparison of techniques for carrier detection. (2938617)
1986
40
A Glanzmann's thrombasthenia cluster among Iraqi Jews in Israel. (6531749)
1984
41
Protein and glycoprotein abnormalities in an unusual subtype of Glanzmann's thrombasthenia. (7152371)
1982
42
Relationship between fibrinogen binding and the platelet glycoprotein deficiencies in Glanzmann's thrombasthenia type I and type II. (6454435)
1981
43
Platelet membrane glycoproteins in thrombasthenia, Bernard-Soulier syndrome, and storage pool disease. (429863)
1979
44
Deletion of the platelet-specific alloantigen PlA1 from platelets in Glanzmann's thrombasthenia. (566280)
1978
45
Platelet membrane defects in Glanzmann's thrombasthenia. Evidence for decreased amounts of two major glycoproteins. (70433)
1977
46
Transient thrombasthenia in a patient with tuberculosis. (4453925)
1974
47
Suspected thrombasthenia in a shetland sheepdog. (4428600)
1974
48
Thrombasthenia. (5542851)
1971
49
Glanzmann's thrombasthenia and pregnancy. (5461433)
1970
50
Thrombasthenia: a study of two siblings. (5706368)
1968

Variations for Thrombasthenia

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Expression for genes affiliated with Thrombasthenia

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Search GEO for disease gene expression data for Thrombasthenia.

Pathways for genes affiliated with Thrombasthenia

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Pathways related to Thrombasthenia according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8ITGA2, ITGA2B, ITGB3
29.8ITGA2, ITGB3, VTN
3
Show member pathways
9.8ITGA2, ITGB3, VTN
49.8EGF, ITGA2B, ITGB3
59.8EGF, ITGA2B, ITGB3
69.7GP1BA, GP9
79.7GP1BA, SELP, VTN
89.6ITGA2, ITGA2B, ITGB3, VTN
99.6ITGA2, ITGA2B, ITGB3, VTN
109.5HPSE, ITGA2, ITGA2B
119.5GP1BA, GP9, ITGA2
129.4GTF3A, ITGB3, SELP
13
Show member pathways
9.2F2, F3, F5, VTN
149.2ITGA2, ITGA2B, PTK2
159.2CD36, GP1BA, ITGA2, ITGA2B, ITGB3
169.1GP1BA, GP9, ITGA2, ITGA2B, ITGB3
178.8CD36, F2, GP9, ITGA2, ITGA2B, ITGB3
18
Show member pathways
8.8F2, ITGA2, ITGA2B, ITGB3, PTK2
19
Show member pathways
8.8EGF, ITGA2, ITGA2B, ITGB3, PTK2
208.8EGF, ITGA2, ITGA2B, ITGB3, PTK2
218.8CD36, GP1BA, GP9, ITGA2, ITGA2B, ITGB3
22
Show member pathways
8.7F2, F3, F5, GP1BA, GP9
23
Show member pathways
8.5EGF, ITGA2, ITGA2B, ITGB3, PTK2, VTN
248.5EGF, ITGA2, ITGA2B, ITGB3, PTK2, VTN
25
Show member pathways
8.5CD36, GP1BA, GP9, ITGA2, ITGA2B, ITGB3
26
Show member pathways
8.5EGF, F2, ITGA2, ITGA2B, ITGB3, PTK2
278.5HPSE, ITGA2, ITGB3, PTK2, VTN
28
Show member pathways
8.2F2, GP1BA, GP9, ITGA2B, ITGB3, PTK2
29
Show member pathways
8.0CD36, EGF, F2, ITGA2, ITGA2B, ITGB3

GO Terms for genes affiliated with Thrombasthenia

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Cellular components related to Thrombasthenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1alphav-beta3 integrin-vitronectin complexGO:007106210.8ITGB3, VTN
2integrin complexGO:000830510.5ITGA2, ITGA2B, ITGB3
3platelet alpha granule membraneGO:003109210.1CD36, ITGA2B, ITGB3, SELP
4external side of plasma membraneGO:00098979.8CD36, ITGA2, ITGA2B, SELP
5cell surfaceGO:00099869.0CD36, F3, GP1BA, ITGA2, ITGA2B, ITGB3
6extracellular spaceGO:00056158.4CD36, EGF, F2, F3, F5, SELP
7plasma membraneGO:00058866.4CD36, EGF, F2, F3, F5, GP1BA

Biological processes related to Thrombasthenia according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:003094910.7ITGB3, VTN
2mesodermal cell differentiationGO:004833310.7ITGA2, ITGB3
3cell-substrate adhesionGO:003158910.6ITGA2, ITGB3
4cell adhesion mediated by integrinGO:003362710.6ITGA2, VTN
5positive regulation of phagocytosis, engulfmentGO:006010010.5CD36, ITGA2
6positive regulation of positive chemotaxisGO:005092710.4F3, ITGA2
7positive regulation of leukocyte migrationGO:000268710.4ITGA2, ITGA2B, SELP
8platelet aggregationGO:007052710.3GP1BA, ITGA2B, ITGB3
9angiogenesis involved in wound healingGO:006005510.2HPSE, ITGB3
10positive regulation of smooth muscle cell migrationGO:001491110.2F3, ITGA2, VTN
11blood coagulation, intrinsic pathwayGO:000759710.1F2, GP1BA, GP9
12leukocyte migrationGO:00509009.9F2, ITGB3, SELP
13positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.9CD36, EGF, ITGB3, VTN
14positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:20000609.8EGF, PTK2
15positive regulation of blood coagulationGO:00301949.6CD36, F2, HPSE
16wound healingGO:00420609.6HPSE, ITGA2, ITGB3
17positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.6F2, PTK2, SELP
18cell-matrix adhesionGO:00071609.5HPSE, ITGA2, ITGA2B, ITGB3, VTN
19platelet degranulationGO:00025769.3CD36, EGF, F5, ITGA2B, ITGB3, SELP
20integrin-mediated signaling pathwayGO:00072299.3ITGA2, ITGA2B, ITGB3, PTK2
21platelet activationGO:00301689.2F2, F5, GP1BA, GP9, ITGB3
22positive regulation of protein kinase B signalingGO:00518979.2F3, HPSE, PTK2
23extracellular matrix organizationGO:00301988.3HPSE, ITGA2, ITGA2B, ITGB3, PTK2, VTN
24cell adhesionGO:00071558.3CD36, GP1BA, GP9, ITGA2, ITGA2B, ITGB3
25blood coagulationGO:00075968.0CD36, F2, F3, F5, GP1BA, GP9

Molecular functions related to Thrombasthenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thrombospondin receptor activityGO:007005310.6CD36, F2
2extracellular matrix bindingGO:005084010.4ITGA2B, ITGB3, VTN
3protein bindingGO:00055154.8CD36, EGF, F2, F3, F5, GP1BA

Sources for Thrombasthenia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet