MCID: THR035
MIFTS: 42

Thrombasthenia malady

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Thrombasthenia

About this section

Aliases & Descriptions for Thrombasthenia:

Name: Thrombasthenia 48 68

Classifications:



Summaries for Thrombasthenia

About this section
MalaCards based summary: Thrombasthenia is related to bernard-soulier syndrome, type c and type 2n von willebrand disease. An important gene associated with Thrombasthenia is ITGA2B (Integrin Subunit Alpha 2b), and among its related pathways are L1CAM interactions and Cell adhesion_Endothelial cell contacts by non-junctional mechanisms. Affiliated tissues include bone, bone marrow and whole blood, and related mouse phenotypes are digestive/alimentary and liver/biliary system.

Related Diseases for Thrombasthenia

About this section

Diseases related to Thrombasthenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1bernard-soulier syndrome, type c30.7F2, GP1BA, GP9, ITGA2, ITGA2B, ITGB3
2type 2n von willebrand disease30.1GP1BA, SELP
3glanzmann thrombasthenia12.5
4thrombasthenia of glanzmann and naegeli, itga2b-related11.8
5thrombasthenia of glanzmann and naegeli, itgb3-related11.8
6bleeding disorder, platelet-type, 16, autosomal dominant11.1
7bleeding disorder, platelet-type, 1711.0
8leukocyte adhesion deficiency, type iii10.8
9leukocyte adhesion deficiency10.8
10schlegelberger grote syndrome10.8
11interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital10.7ITGA2B, ITGB3
12lower urinary tract calculus10.6F2, ITGA2
13rasa1-related disorders10.5F2, MTHFR
14cervical dermoid cyst10.5GP1BA, ITGA2B, ITGB3
15typhoid fever10.5F2, MTHFR
16familial glomangioma10.5F2, F3
17ariboflavinosis10.4F2, F3
18fasciitis10.4F2, ITGA2
19c1 inhibitor deficiency10.4F2, GP1BA, ITGB3
20myiasis10.4F2, F3
21michels caskey syndrome10.4F5, MTHFR
22cavernous hemangioma of face10.4F2, F3
23marek disease10.4F2, F3
24congenital stenosis of the inferior vena cava10.4F5, MTHFR
25hypertensive heart disease10.4F2, MTHFR
26ovarian gonadoblastoma10.4F2, F3
27cerebral angioma10.4F2, F3
28sacrococcygeal teratoma10.4F2, ITGA2, MTHFR
29collagenous colitis10.4F2, F5
30von willibrand disease, type 310.4F2, F3
31ameloblastic carcinoma10.4F5, MTHFR
32brill-zinsser disease10.4F2, F3
33epididymo-orchitis10.3F2, F3
34bartholin's gland adenoma10.3F2, F5
35histoplasmosis10.3F2, MTHFR, SELP
36fetal brain disruption sequence10.3GP1BA, ITGA2, ITGA2B, ITGB3
37psychosexual disorder10.3F2, MTHFR, SELP
38thrombophilia due to thrombin defect10.3F2, F5
39pregnancy loss, recurrent 110.3F5, MTHFR
40factor x deficiency10.3EGF, F2, F3
41colon carcinoma in situ10.3F3, ITGA2B, SELP
42alpha-2-plasmin inhibitor deficiency10.3F2, GP1BA, MTHFR
43scapuloperoneal myopathy, x-linked dominant10.3EGF, F2, F3
44acquired fructose intolerance10.3F3, F5
45atrophic gastritis10.3GP1BA, ITGA2B, ITGB3, SELP
46subcortical arteriosclerotic encephalopathy10.3F2, F5, MTHFR
47thrombocytopenic purpura, autoimmune10.3GP1BA, ITGA2B, ITGB3, SELP
48unicentric castleman disease10.3F2, F5, MTHFR
49thyroid hyalinizing trabecular adenoma10.3F2, F5, MTHFR
50wfs1-related disorders10.2F2, F3, GP1BA

Graphical network of the top 20 diseases related to Thrombasthenia:



Diseases related to thrombasthenia

Symptoms & Phenotypes for Thrombasthenia

About this section

MGI Mouse Phenotypes related to Thrombasthenia according to GeneCards Suite gene sharing:

41 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.0CD36, EGF, F2, ITGA2B, ITGB3, PTK2
2MP:00053708.5CD36, F5, ITGB3, PSMG1, PTK2, SELP
3MP:00053918.4CD36, EGF, F3, ITGB3, MTHFR, SELP
4MP:00028738.3EGF, F2, F3, ITGA2, ITGB3, PSMG1
5MP:00053877.8CD36, EGF, F2, F3, HPSE, ITGA2B
6MP:00036317.4CD36, F2, F3, F5, ITGB3, MTHFR
7MP:00107717.3EGF, F2, F3, F5, HPSE, ITGA2
8MP:00053787.3CD36, EGF, F2, F3, F5, ITGB3
9MP:00053847.2CD36, F3, GP1BA, HPSE, ITGA2, ITGA2B
10MP:00053857.2CD36, F2, F3, F5, HPSE, ITGA2B
11MP:00053767.1CD36, F2, F3, F5, GP1BA, ITGA2
12MP:00053976.8CD36, F2, F3, GP1BA, GP9, HPSE

Drugs & Therapeutics for Thrombasthenia

About this section

Drugs for Thrombasthenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Mycophenolic acidapprovedPhase 193924280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
 
Melbex
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolsäure
Myfortic
2
AbataceptapprovedPhase 1192332348-12-610237
Synonyms:
CTLA4-Ig
 
CTLA4-IgG4m
CTLA4Ig
CTLA4IgG4m
3
Mycophenolate mofetilapproved, investigationalPhase 1939128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil
4
Cyclosporineapproved, investigational, vet_approvedPhase 191579217-60-0, 59865-13-35284373, 6435893
Synonyms:
1c5f
1cyn
30024_FLUKA
30024_SIGMA
59865-13-3
79217-60-0
AC1L1EQW
AC1NQXJE
AC1NR4C4
AC1NUQK3
AC1NUZNC
AC1O5KOG
AC1Q2UDG
Ambap59865-13-3
Ambotz59865-13-3
Antibiotic S 7481F1
BMT-ABA-SAR-MLE-VAL-MLE-ALA-ALA-MLE-MLE-MVA
BMT-ABA-SAR-MLE-VAL-MLE-ALA-DAL-MLE-MLE-MVA
BPBio1_000496
BRD-A64290322-001-01-6
BRD-A69815203-001-04-3
BRD-K13533483-001-03-0
BSPBio_000450
BSPBio_001596
BSPBio_003186
C 3662
C05086
C1832_SIGMA
C3662_SIGMA
C62H111N11O12
CB-01-09 MMX
CHEBI:106343
CHEBI:328305
CHEBI:4031
CHEMBL160
CHEMBL386389
CHEMBL532318
CID2909
CID5280754
CID5284373
CID5458585
CID5497195
CID6435893
CSA
CYCLOSPORIN A (SEE ALSO TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A))
CYCLOSPORIN A, USP
Ciclosporin
Ciclosporin (JP15)
Ciclosporina
Ciclosporine
Ciclosporinum
Cipol N
Cipol-N
Consupren
Consupren S
CsA
CsA & IFN.alpha.
CyA
Cyclokat
Cyclosporin
Cyclosporin A
Cyclosporin A & IFN.alpha.
Cyclosporin A Implant
Cyclosporin A, Tolypocladium inflatum
Cyclosporine (USP)
Cyclosporine A
Cyclosporine [USAN]
D00184
DE-076
DivK1c_000871
EU-0100242
Equoral
GNF-Pf-2808
Gengraf
Gengraf (TN)
HMS1569G12
HMS1791P18
HMS1921L20
HMS1989P18
HMS2089A09
HMS2092F06
HMS502L13
Helv Chim Acta 60: 1568 (1977)
 
I06-0379
I06-0966
IDI1_000871
KBio1_000871
KBio2_000780
KBio2_003348
KBio2_005916
KBio3_002686
KBioGR_001898
KBioSS_000780
LMPK14000003
LS-257
LS-58836
Lopac0_000242
MLS000028376
MLS001333756
MLS002153454
MLS002207033
Mitogard
Modusik-A
MolPort-000-760-988
MolPort-005-934-008
MolPort-006-705-994
NCGC00093704-01
NCGC00093704-02
NCGC00093704-03
NCGC00093704-04
NCGC00093704-05
NCGC00093704-06
NCGC00093704-07
NCGC00093704-08
NCGC00164258-01
NCGC00164258-02
NINDS_000871
NSC290193
Neoplanta
Neoral
Neoral (TN)
NeuroSTAT
Nova-22007
OL 27-400
OL-27400
OLO-400
Papilock
Prestwick2_000435
Prestwick3_000435
Prestwick_731
Pulminiq
Ramihyphin A
Restasis
Restasis (TN)
S-Neoral
S1514_Selleck
SDZ-OXL 400
SMR000058578
SPBio_001467
SPECTRUM1502202
ST-603
Sandimmun
Sandimmun Neoral
Sandimmune
Sandimmune (TN)
Sandimmune, Gengraf, Restasis, Atopica, Sangcya, Cyclosporine
Sang-2000
Sang-35
SangCyA
Sangcya
Sigmasporin
Sigmasporin Microoral
Spectrum2_001484
Spectrum3_001593
Spectrum4_001279
Spectrum5_001628
Spectrum_000300
TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A)
Vekacia
Zyclorin
cyclophorine
cyclosporin A
cyclosporine
from Tolypocladium inflatum (Trichoderma polysporin)
nchembio.184-comp6
nchembio.301-comp5
nchembio.342-comp1
5Immunosuppressive AgentsPhase 112770
6Antirheumatic AgentsPhase 110627
7Antifibrinolytic Agents459
8Hemostatics1359
9Dermatologic Agents5674

Interventional clinical trials:

idNameStatusNCT IDPhase
1Bioequivalence of NovoSeven® and a NovoSeven® Formulation Stable at Room Temperature in Healthy Male SubjectsCompletedNCT01561417Phase 1
2BMT Abatacept for Non-Malignant DiseasesRecruitingNCT01917708Phase 1
3Evaluation of Menses in Congenital Bleeding DisordersUnknown statusNCT01261936
4Evaluation of a New Approach of the Diagnosis of Constitutional Functional Disorders of PlateletsUnknown statusNCT01957345
5Observational Registry of the Treatment of Glanzmann's ThrombastheniaCompletedNCT01476423
6Observational Study on the Efficacy and Safety of NovoSeven® During "Real-life" Usage in GermanyCompletedNCT00697320
7The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders.RecruitingNCT00230165
8A Study to Evaluate Safety and Efficacy of NovoSeven® in Patients With Glanzmann's Thrombasthenia in JapanActive, not recruitingNCT01876745
9Alefacept and Allogeneic Hematopoietic Stem Cell TransplantationSuspendedNCT01319851

Search NIH Clinical Center for Thrombasthenia

Genetic Tests for Thrombasthenia

About this section

Anatomical Context for Thrombasthenia

About this section

MalaCards organs/tissues related to Thrombasthenia:

36
Bone, Bone marrow, Whole blood, Monocytes, Testes, Endothelial, Myeloid

Publications for Thrombasthenia

About this section

Articles related to Thrombasthenia:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B. (28078347)
2017
2
Surgical procedures in patients with Glanzmann's thrombasthenia: case series and literature review. (27273143)
2016
3
Efficacy of tranexamic acid for the prevention of bleeding in patients with von Willebrand disease and Glanzmann thrombasthenia: a controlled, before and after trial. (27478149)
2016
4
Linkage disequilibrium amongst ITGA2B and ITGB3 gene variants in patients with Glanzmann thrombasthenia confirms that most disease-causing mutations are recent. (27469266)
2016
5
Identification and Characterization of Glanzmann Thrombasthenia in 2 Closely Related Mixed-breed Dogs. (26764135)
2016
6
No genetic abnormalities identified in I+2IIb and I^3: phenotype overcomes genotype in Glanzmann thrombasthenia. (27808476)
2016
7
Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia. (26452979)
2016
8
Endometriosis and GlanzmannA9s thrombasthenia. (27655515)
2016
9
Immunisation against I+IIbI^3 and I+vI^3 in a type 1 variant of Glanzmann's thrombasthenia caused by a missense mutation Gly540Asp on I^3. (27098940)
2016
10
Glanzmann thrombasthenia in a child manifesting after dengue infection. (28050106)
2016
11
Total Extraction as a Treatment for Anaemia in a Patient of Glanzmann's Thrombasthenia with Chronic Gingival Bleed: Case Report. (26894187)
2016
12
Is there a role for antiangiogenic therapy, bevacizumab, in the treatment of recurrent digestive bleeding due to angiodysplasia in Glanzmann's thrombasthenia? (27352634)
2016
13
Perioperative ROTEM and ROTEMplatelet monitoring in a case of Glanzmann's thrombasthenia. (26825624)
2016
14
Glanzmann thrombasthenia in pregnancy: Optimising maternal and fetal outcomes. (27829878)
2016
15
Successful management of perioperative hemostasis in a patient with Glanzmann thrombasthenia who underwent a right total mastectomy. (27696190)
2016
16
Glanzmann Thrombasthenia: A Clinicopathological Profile. (27539755)
2016
17
New Insights Into the Treatment of Glanzmann Thrombasthenia. (26968829)
2016
18
Simultaneous occurrence of intussusception and duodenal haematoma in a patient with Glanzmann's thrombasthenia. (28051053)
2016
19
Live birth following an intracytoplasmic sperm injection in a patient with Glanzmann thrombasthenia. (26466915)
2015
20
Glanzmann's thrombasthenia: meeting the anticoagulation challenge. (25939445)
2015
21
Second trimester prenatal diagnosis in Glanzmann's Thrombasthenia. (26709505)
2015
22
I+IIbI^3 variants defined by next-generation sequencing: Predicting variants likely to cause Glanzmann thrombasthenia. (25827233)
2015
23
Glanzmann's thrombasthenia: a rare case of spontaneous bilateral hemotympanum. (25613489)
2015
24
Acute Epidural Hematoma Following Acute Subdural Hematoma Evacuation in a Child With Glanzmann Thrombasthenia. (26421897)
2015
25
Glanzmann's Thrombasthenia Diagnosed following Knee Arthroscopy. (26000186)
2015
26
Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia. (26290457)
2015
27
Long-term therapy with bevacizumab in a patient with Glanzmann's thrombasthenia and recurrent digestive bleeding due to gastrointestinal angiodysplastic lesions. (25646919)
2015
28
Abnormal cytoplasmic extensions associated with active I+IIbI^3 are probably the cause for macrothrombocytopenia in Glanzmann thrombasthenia-like syndrome. (25806962)
2015
29
Novel mutations of integrin I+IIb and I^3 genes in Turkish children with Glanzmann's thrombasthenia. (25734216)
2015
30
Successful Treatment of Refractory Gastrointestinal Bleeding by Systemic (Oral) Ankaferd Blood Stopper in a Patient with Glanzmann Thrombasthenia. (26167349)
2015
31
The international, prospective Glanzmann Thrombasthenia Registry: treatment modalities and outcomes of non-surgical bleeding episodes in patients with Glanzmann thrombasthenia. (26001793)
2015
32
Glanzmann thrombasthenia in Pakistan: molecular analysis and identification of novel mutations. (26096001)
2015
33
The Use of Ankaferd Blood Stopper in a Child With Glanzmann Thrombasthenia With Gingival Bleeding. (26207779)
2015
34
Expanding the Mutation Spectrum Affecting I+IIbI^3 Integrin in Glanzmann Thrombasthenia: Screening of the ITGA2B and ITGB3 Genes in a Large International Cohort. (25728920)
2015
35
The international, prospective Glanzmann Thrombasthenia Registry: treatment and outcomes in surgical intervention. (26001792)
2015
36
Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options. (26185478)
2015
37
Successful use of recombinant factor VIIa in a patient with acquired Glanzmann thrombasthenia. (25471665)
2015
38
Stem Cell Transplant in Severe Glanzmann Thrombasthenia in an Adult Patient. (26134714)
2015
39
Glanzmann thrombasthenia associated with human immunodeficiency virus-positive patient. (24829739)
2014
40
Phosphatidylserine exposure, microparticle formation and mitochondrial depolarisation in Glanzmann thrombasthenia platelets. (24477274)
2014
41
Spontaneous hemarthrosis in combined Glanzmann thrombasthenia and type 2N von Willebrand disease. (24418945)
2014
42
Use of recombinant activated factor VII in patients with Glanzmann's thrombasthenia: a review of the literature. (24948404)
2014
43
NovoSeven (recombinant factor VIIa) for the treatment of bleeding episodes and perioperative management in patients with Glanzmann's thrombasthenia. (25387838)
2014
44
Unusual redo mitral valve replacement for bleeding in Glanzmann thrombasthenia. (24904176)
2014
45
Diagnosis of Glanzmann thrombasthenia by whole blood impedance analyzer (MEA) vs. light transmission aggregometry. (25537026)
2014
46
Management of Pregnancy in a Chilean Patient with Congenital Deficiency of Factor VII and Glanzmann's Thrombasthenia Variant. (25525535)
2014
47
Hematological and surgical management in Glanzmann's thrombasthenia: a case report. (24739923)
2014
48
Coincidence of Glanzmann's thrombasthenia with hereditary haemorrhagic telengiectasia in a man with gastrointestinal bleeding. (25083772)
2014
49
Use of allogeneic stem cell transplantation for moderate-severe Glanzmann thrombasthenia. (25548835)
2014
50
Clinical Management of Glanzmann's Thrombasthenia: A Case Report. (24910701)
2014

Variations for Thrombasthenia

About this section

Expression for genes affiliated with Thrombasthenia

About this section
Search GEO for disease gene expression data for Thrombasthenia.

Pathways for genes affiliated with Thrombasthenia

About this section

Pathways related to Thrombasthenia according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8ITGA2, ITGA2B, ITGB3
29.8ITGA2, ITGB3, VTN
3
Show member pathways
9.8ITGA2, ITGB3, VTN
49.8EGF, ITGA2B, ITGB3
59.8EGF, ITGA2B, ITGB3
69.7GP1BA, GP9
79.7GP1BA, SELP, VTN
89.6ITGA2, ITGA2B, ITGB3, VTN
99.6ITGA2, ITGA2B, ITGB3, VTN
109.5HPSE, ITGA2, ITGA2B
119.5GP1BA, GP9, ITGA2
129.4GTF3A, ITGB3, SELP
13
Show member pathways
9.2F2, F3, F5, VTN
149.2ITGA2, ITGA2B, PTK2
159.2CD36, GP1BA, ITGA2, ITGA2B, ITGB3
169.1GP1BA, GP9, ITGA2, ITGA2B, ITGB3
178.8CD36, F2, GP9, ITGA2, ITGA2B, ITGB3
18
Show member pathways
8.8F2, ITGA2, ITGA2B, ITGB3, PTK2
19
Show member pathways
8.8EGF, ITGA2, ITGA2B, ITGB3, PTK2
208.8EGF, ITGA2, ITGA2B, ITGB3, PTK2
218.8CD36, GP1BA, GP9, ITGA2, ITGA2B, ITGB3
22
Show member pathways
8.7F2, F3, F5, GP1BA, GP9
23
Show member pathways
8.5EGF, ITGA2, ITGA2B, ITGB3, PTK2, VTN
248.5EGF, ITGA2, ITGA2B, ITGB3, PTK2, VTN
25
Show member pathways
8.5CD36, GP1BA, GP9, ITGA2, ITGA2B, ITGB3
26
Show member pathways
8.5EGF, F2, ITGA2, ITGA2B, ITGB3, PTK2
278.5HPSE, ITGA2, ITGB3, PTK2, VTN
28
Show member pathways
8.2F2, GP1BA, GP9, ITGA2B, ITGB3, PTK2
29
Show member pathways
8.0CD36, EGF, F2, ITGA2, ITGA2B, ITGB3

GO Terms for genes affiliated with Thrombasthenia

About this section

Cellular components related to Thrombasthenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1alphav-beta3 integrin-vitronectin complexGO:007106210.9ITGB3, VTN
2integrin complexGO:000830510.6ITGA2, ITGA2B, ITGB3
3external side of plasma membraneGO:000989710.2CD36, ITGA2, ITGA2B, SELP
4cell surfaceGO:00099869.6CD36, F3, GP1BA, ITGA2, ITGA2B, ITGB3
5platelet alpha granule membraneGO:00310929.5CD36, ITGA2B, ITGB3, SELP
6extracellular spaceGO:00056159.2CD36, EGF, F2, F3, F5, SELP
7plasma membraneGO:00058866.6CD36, EGF, F2, F3, F5, GP1BA

Biological processes related to Thrombasthenia according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1cell-substrate adhesionGO:003158910.7ITGA2, ITGB3
2cell adhesion mediated by integrinGO:003362710.7ITGA2, VTN
3mesodermal cell differentiationGO:004833310.7ITGA2, ITGB3
4positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:003094910.6ITGB3, VTN
5positive regulation of phagocytosis, engulfmentGO:006010010.5CD36, ITGA2
6angiogenesis involved in wound healingGO:006005510.5HPSE, ITGB3
7positive regulation of positive chemotaxisGO:005092710.4F3, ITGA2
8platelet aggregationGO:007052710.4GP1BA, ITGA2B, ITGB3
9leukocyte migrationGO:005090010.4F2, ITGB3, SELP
10positive regulation of leukocyte migrationGO:000268710.4ITGA2, ITGA2B, SELP
11blood coagulation, intrinsic pathwayGO:000759710.2F2, GP1BA, GP9
12positive regulation of smooth muscle cell migrationGO:001491110.1F3, ITGA2, VTN
13positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.1CD36, EGF, ITGB3, VTN
14positive regulation of blood coagulationGO:003019410.0CD36, F2, HPSE
15positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:20000609.9EGF, PTK2
16cell-matrix adhesionGO:00071609.8HPSE, ITGA2, ITGA2B, ITGB3, VTN
17positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.7F2, PTK2, SELP
18integrin-mediated signaling pathwayGO:00072299.7ITGA2, ITGA2B, ITGB3, PTK2
19platelet activationGO:00301689.6F2, F5, GP1BA, GP9, ITGB3
20wound healingGO:00420609.5HPSE, ITGA2, ITGB3
21platelet degranulationGO:00025769.5CD36, EGF, F5, ITGA2B, ITGB3, SELP
22positive regulation of protein kinase B signalingGO:00518979.3F3, HPSE, PTK2
23cell adhesionGO:00071559.0CD36, GP1BA, GP9, ITGA2, ITGA2B, ITGB3
24extracellular matrix organizationGO:00301989.0HPSE, ITGA2, ITGA2B, ITGB3, PTK2, VTN
25blood coagulationGO:00075968.7CD36, F2, F3, F5, GP1BA, GP9

Molecular functions related to Thrombasthenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix bindingGO:005084010.7ITGA2B, ITGB3, VTN
2thrombospondin receptor activityGO:00700539.9CD36, F2
3protein bindingGO:00055154.9CD36, EGF, F2, F3, F5, GP1BA

Sources for Thrombasthenia

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet