MCID: THR035
MIFTS: 39

Thrombasthenia malady

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Thrombasthenia

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Aliases & Descriptions for Thrombasthenia:

Name: Thrombasthenia 48 68

Classifications:



Summaries for Thrombasthenia

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MalaCards based summary: Thrombasthenia is related to glanzmann thrombasthenia and thrombasthenia of glanzmann and naegeli, itga2b-related. An important gene associated with Thrombasthenia is ITGA2B (Integrin Subunit Alpha 2b), and among its related pathways are Signal transduction by L1 and Ephrin B reverse signaling. Affiliated tissues include bone, bone marrow and whole blood, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Related Diseases for Thrombasthenia

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Diseases related to Thrombasthenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1glanzmann thrombasthenia12.5
2thrombasthenia of glanzmann and naegeli, itga2b-related11.8
3thrombasthenia of glanzmann and naegeli, itgb3-related11.8
4bleeding disorder, platelet-type, 1711.6
5bleeding disorder, platelet-type, 16, autosomal dominant11.1
6bernard-soulier syndrome, type c10.8
7leukocyte adhesion deficiency, type iii10.8
8leukocyte adhesion deficiency10.8
9schlegelberger grote syndrome10.8
10interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital10.1ITGA2B, ITGB3
11facial dysmorphism-anorexia-cachexia-eye and skin anomalies syndrome10.1ITGA2B, ITGB3
12supraumbilical midabdominal raphe and facial cavernous hemangiomas10.1F2, ITGB3
13severe nonproliferative diabetic retinopathy10.1ITGA2B, ITGB3
14coccidioidomycosis10.1F2, ITGA2B
15gluten allergy10.1ITGA2B, ITGB3
16immunodeficiency 2010.0ITGA2B, ITGB3
17villous adenoma10.0F2, ITGB3
18hereditary alpha tryptasemia syndrome10.0F2, ITGB3
19autoimmune disease of central nervous system10.0F2, ITGB3
20membranoproliferative glomerulonephritis10.0F2, ITGA2B
21mental depression10.0ITGA2, ITGA2B
22thrombocytopenia10.0
23thrombosis10.0
24von willebrand's disease10.0
25ischemic fasciitis10.0F2, ITGA2
26kondoh syndrome9.9F2, ITGA2
27intravascular fasciitis9.9F2, ITGA2
28essential thrombocythemia9.9F2, ITGA2B, ITGB3
29bone development disease9.9F2, ITGB3
30ocular hyperemia9.9F2, ITGA2B, ITGB3
31myeloproliferative neoplasm9.9F2, ITGA2B, ITGB3
32perichondritis of auricle9.9F2, ITGA2B, ITGB3
33basilar artery insufficiency9.9F2, ITGA2B, ITGB3
34gingivitis9.9
35duodenitis9.9
36cervix small cell carcinoma9.9F2, ITGA2B
37scar contracture9.8F2, ITGA2
38leukemia9.8
39hemarthrosis9.8
40fetal macrosomia9.8ITGA2, ITGA2B, ITGB3
41atherosclerosis9.7
42hematopoietic stem cell transplantation9.7
43lymphoma9.7
44endometriosis9.7
45purpura9.7
46hermansky-pudlak syndrome9.7
47immunodeficiency 219.6F2, ITGA2, ITGA2B, ITGB3
48haemonchiasis9.6F2, ITGA2, ITGA2B, ITGB3
49tracheal disease9.6F2, ITGA2, ITGA2B, ITGB3
50myocardial infarction9.6F2, ITGA2, ITGA2B, ITGB3

Graphical network of the top 20 diseases related to Thrombasthenia:



Diseases related to thrombasthenia

Symptoms & Phenotypes for Thrombasthenia

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MGI Mouse Phenotypes related to Thrombasthenia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.3F2, ITGA2, ITGA2B, ITGB3, VTN
2MP:00053768.3F2, ITGA2, ITGA2B, ITGB3, VTN
3MP:00028738.0F2, ITGA2, ITGB3, VTN

Drugs & Therapeutics for Thrombasthenia

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Drugs for Thrombasthenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AbataceptapprovedPhase 1197332348-12-610237
Synonyms:
CTLA4-Ig
 
CTLA4-IgG4m
CTLA4Ig
CTLA4IgG4m
2
Mycophenolate mofetilapproved, investigationalPhase 1952128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil
3
Mycophenolic acidapprovedPhase 195224280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
 
Melbex
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolsäure
Myfortic
4
Cyclosporineapproved, investigational, vet_approvedPhase 192279217-60-0, 59865-13-35284373, 6435893
Synonyms:
1c5f
1cyn
30024_FLUKA
30024_SIGMA
59865-13-3
79217-60-0
AC1L1EQW
AC1NQXJE
AC1NR4C4
AC1NUQK3
AC1NUZNC
AC1O5KOG
AC1Q2UDG
Ambap59865-13-3
Ambotz59865-13-3
Antibiotic S 7481F1
BMT-ABA-SAR-MLE-VAL-MLE-ALA-ALA-MLE-MLE-MVA
BMT-ABA-SAR-MLE-VAL-MLE-ALA-DAL-MLE-MLE-MVA
BPBio1_000496
BRD-A64290322-001-01-6
BRD-A69815203-001-04-3
BRD-K13533483-001-03-0
BSPBio_000450
BSPBio_001596
BSPBio_003186
C 3662
C05086
C1832_SIGMA
C3662_SIGMA
C62H111N11O12
CB-01-09 MMX
CHEBI:106343
CHEBI:328305
CHEBI:4031
CHEMBL160
CHEMBL386389
CHEMBL532318
CID2909
CID5280754
CID5284373
CID5458585
CID5497195
CID6435893
CSA
CYCLOSPORIN A (SEE ALSO TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A))
CYCLOSPORIN A, USP
Ciclosporin
Ciclosporin (JP15)
Ciclosporina
Ciclosporine
Ciclosporinum
Cipol N
Cipol-N
Consupren
Consupren S
CsA
CsA & IFN.alpha.
CyA
Cyclokat
Cyclosporin
Cyclosporin A
Cyclosporin A & IFN.alpha.
Cyclosporin A Implant
Cyclosporin A, Tolypocladium inflatum
Cyclosporine (USP)
Cyclosporine A
Cyclosporine [USAN]
D00184
DE-076
DivK1c_000871
EU-0100242
Equoral
GNF-Pf-2808
Gengraf
Gengraf (TN)
HMS1569G12
HMS1791P18
HMS1921L20
HMS1989P18
HMS2089A09
HMS2092F06
HMS502L13
Helv Chim Acta 60: 1568 (1977)
 
I06-0379
I06-0966
IDI1_000871
KBio1_000871
KBio2_000780
KBio2_003348
KBio2_005916
KBio3_002686
KBioGR_001898
KBioSS_000780
LMPK14000003
LS-257
LS-58836
Lopac0_000242
MLS000028376
MLS001333756
MLS002153454
MLS002207033
Mitogard
Modusik-A
MolPort-000-760-988
MolPort-005-934-008
MolPort-006-705-994
NCGC00093704-01
NCGC00093704-02
NCGC00093704-03
NCGC00093704-04
NCGC00093704-05
NCGC00093704-06
NCGC00093704-07
NCGC00093704-08
NCGC00164258-01
NCGC00164258-02
NINDS_000871
NSC290193
Neoplanta
Neoral
Neoral (TN)
NeuroSTAT
Nova-22007
OL 27-400
OL-27400
OLO-400
Papilock
Prestwick2_000435
Prestwick3_000435
Prestwick_731
Pulminiq
Ramihyphin A
Restasis
Restasis (TN)
S-Neoral
S1514_Selleck
SDZ-OXL 400
SMR000058578
SPBio_001467
SPECTRUM1502202
ST-603
Sandimmun
Sandimmun Neoral
Sandimmune
Sandimmune (TN)
Sandimmune, Gengraf, Restasis, Atopica, Sangcya, Cyclosporine
Sang-2000
Sang-35
SangCyA
Sangcya
Sigmasporin
Sigmasporin Microoral
Spectrum2_001484
Spectrum3_001593
Spectrum4_001279
Spectrum5_001628
Spectrum_000300
TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A)
Vekacia
Zyclorin
cyclophorine
cyclosporin A
cyclosporine
from Tolypocladium inflatum (Trichoderma polysporin)
nchembio.184-comp6
nchembio.301-comp5
nchembio.342-comp1
5Antirheumatic AgentsPhase 110956
6Immunosuppressive AgentsPhase 113086
7
Busulfanapproved, investigational54555-98-12478
Synonyms:
1, 4-Dimethanesulfonoxybutane
1, 4-Dimethylsulfonoxybutane
1, {4-Bis[methanesulfonoxy]butane}
1,4-BUTANEDIOL DIMETHANESULFONATE
1,4-Bis(methanesulfonoxy)butane
1,4-Bis(methanesulfonyloxy)butane
1,4-Bis[methanesulfonoxy]butane
1,4-Butanedi yl dimethanesulfonate
1,4-Butanediol dimethanesulfonate
1,4-Butanediol dimethanesulphonate
1,4-Butanediol dimethylsulfonate
1,4-Butanediol, dimethanesulfonate
1,4-Butanediol, dimethanesulphonate
1,4-Butanediyl dimethanesulfonate
1,4-Di(methylsulfonoxy)butane
1,4-Dimesyloxybutane
1,4-Dimethane sulfonyl oxybutane
1,4-Dimethanesulfonoxybutane
1,4-Dimethanesulfonoxylbutane
1,4-Dimethanesulfonyloxybutane
1,4-Dimethanesulphonyloxybutane
1,4-Dimethylsulfonoxybutane
1,4-Dimethylsulfonyloxybutane
2041 C. B
2041 C. B.
2041 C.B
2041 C.B.
4-((Methylsulfonyl)oxy)butyl methanesulfonate
4-methylsulfonyloxybutyl methanesulfonate
55-98-1
AC-198
AC1L1DRQ
AC1Q4GRQ
AI3-25012
AKOS003614975
AN 33501
Ambap55-98-1
B1022
B2635_FLUKA
B2635_SIGMA
BRN 1791786
BSPBio_001920
BUSULFAN (1,4-BUTANEDIOL, DIMETHANESULFONATE)
Bisulfex
Busilvex
Busulfan
Busulfan (JP15/USP/INN)
Busulfan GlaxoSmithKline Brand
Busulfan Orphan Brand
Busulfan Wellcome
Busulfan Wellcome Brand
Busulfan [INN:JAN]
Busulfano
Busulfano [INN-Spanish]
Busulfanum
Busulfanum [INN-Latin]
Busulfex
Busulphan
Busulphane
Butanedioldimethanesulfonate
Buzulfan
C.B. 2041
C6H14O6S2
CB 2041
CCRIS 418
CHEBI:28901
CHEMBL820
CID2478
CPD000058613
Citosulfan
D002066
D00248
DB01008
DivK1c_000847
EINECS 200-250-2
FT-0083567
G.T. 41
GT 2041
GT 41
Glaxo Wellcome Brand of Busulfan
GlaxoSmithKline Brand of Busulfan
Glyzophrol
HMS1920I07
HMS2091O09
HMS502K09
 
HSDB 7605
I09-1371
IDI1_000847
InChI=1/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
KBio1_000847
KBio2_000512
KBio2_003080
KBio2_005648
KBio3_001420
KBioGR_000698
KBioSS_000512
LS-1358
Leucosulfan
MLS001076666
MYLERAN (TN)
Mablin
Methanesulfonic
Methanesulfonic acid, tetram ethylene ester
Methanesulfonic acid, tetramethylene ester
Mielevcin
Mielosan
Mielucin
Milecitan
Mileran
Misulban
Mitosan
Mitostan
MolPort-001-783-406
Myeleukon
Myeloleukon
Myelosan
Myelosanum
Mylecytan
Myleran
Myleran Tablets
Myleran tablets
Myleran, Busulfex, Busulfan
Mylerlan
NCGC00090905-01
NCGC00090905-02
NCGC00090905-03
NCGC00090905-04
NCGC00090905-05
NCGC00090905-06
NCGC00090905-07
NCI-C01592
NCI60_041640
NCIMech_000192
NINDS_000847
NSC 750
NSC-750
NSC-750sulphabutin
NSC750
Orphan Brand of Busulfan
Prestwick_989
S1692_Selleck
SAM002554887
SMR000058613
SPBio_000253
SPECTRUM1500152
ST50825921
Spectrum2_000067
Spectrum3_000320
Spectrum4_000259
Spectrum5_000928
Spectrum_000092
Sulfabutin
Sulfabutin (VAN)
Sulphabutin
Tetramethylene Dimethane Sulfonate
Tetramethylene bis(methanesulfonate)
Tetramethylene bis[methanesulfonate]
Tetramethylene dimethane sulfonate
Tetramethylene {bis[methanesulfonate]}
Tetramethylenester Kyseliny Methansulfonove
Tetramethylenester kyseliny methansulfonove
Tetramethylenester kyseliny methansulfonove [Czech]
UNII-G1LN9045DK
WLN: WS1&O4OSW1
Wellcome Brand of Busulfan
Wellcome, Busulfan
X 149
acid, tetramethylene ester
alkylating agent: crosslinks guanine residues
busulfan
butane-1,4-diyl dimethanesulfonate
n-Butane-1,3-di(methylsulfonate)
8
Fludarabineapproved115421679-14-1, 75607-67-930751
Synonyms:
(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
2-F-ARAA
2-F-ara-A
2-Fluoro Ara-A
2-Fluoro-9-beta-D-arabinofuranosyladenine
2-fluoro ARA-A
21679-14-1
9-beta-D-Arabinofuranosyl-2-fluoroadenine
9-beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine
9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- (9CI)
AC1LCW8I
AC1Q51CF
C10H12FN5O4
CCRIS 3382
CHEMBL1568
CID657237
CPD000058874
D07966
EINECS 244-525-5
F-Ara-A
FAMP
FT-0082766
FaraA
Fludara
Fludara, Fludarabine
 
Fludarabina
Fludarabina [Spanish]
Fludarabine
Fludarabine (INN)
Fludarabine 5'-monophosphate
Fludarabine [INN]
Fludarabine monophosphate
Fludarabine phosphate
Fludarabinum
Fludarabinum [Latin]
Fludura
Fluradosa
Fluradosa (TN)
HSDB 6964
I14-4978
LS-15061
MLS000028687
NSC 118218
NSC 118218H
NSC-118218
S1491_Selleck
SAM002548956
SMR000058874
SQ Fludarabine
UNII-1X9VK9O1SC
UNII-P2K93U8740
ZINC04216238
9
Ironapproved11657439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
 
Ed-In-Sol
Eisen
Electrolytic iron
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feronate
Ferretts
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
Ferrum metallicum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron powder
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, carbonyl
Iron, electrolytic
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
Iron, reduced
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Reduced iron
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Vitedyn-Slo
Yieronia
fer
ferrous iron
hierro
10
Cyclophosphamideapproved, investigational293550-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Anhydrous cyclophosphamide
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
 
DB00531
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
11
alemtuzumabapproved, investigational310216503-57-0
Synonyms:
Campath
 
MabCampath
alemtuzumab
12Hemostatics1443
13Antifibrinolytic Agents484
14Antilymphocyte Serum408
15Dermatologic Agents5806

Interventional clinical trials:

idNameStatusNCT IDPhase
1Bioequivalence of NovoSeven® and a NovoSeven® Formulation Stable at Room Temperature in Healthy Male SubjectsCompletedNCT01561417Phase 1
2BMT Abatacept for Non-Malignant DiseasesRecruitingNCT01917708Phase 1
3Evaluation of Menses in Congenital Bleeding DisordersUnknown statusNCT01261936
4Evaluation of a New Approach of the Diagnosis of Constitutional Functional Disorders of PlateletsUnknown statusNCT01957345
5Observational Registry of the Treatment of Glanzmann's ThrombastheniaCompletedNCT01476423
6Observational Study on the Efficacy and Safety of NovoSeven® During "Real-life" Usage in GermanyCompletedNCT00697320
7The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders.RecruitingNCT00230165
8Hematopoietic Stem Cell Transplant for High Risk HemoglobinopathiesRecruitingNCT02179359
9A Study to Evaluate Safety and Efficacy of NovoSeven® in Patients With Glanzmann's Thrombasthenia in JapanActive, not recruitingNCT01876745
10Alefacept and Allogeneic Hematopoietic Stem Cell TransplantationTerminatedNCT01319851

Search NIH Clinical Center for Thrombasthenia

Genetic Tests for Thrombasthenia

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Anatomical Context for Thrombasthenia

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MalaCards organs/tissues related to Thrombasthenia:

36
Bone, Bone marrow, Whole blood, Monocytes, Testes, Endothelial, Myeloid

Publications for Thrombasthenia

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Articles related to Thrombasthenia:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Should studies on Glanzmann thrombasthenia not be telling us more about cardiovascular disease and other major illnesses? (28395882)
2017
2
Oral Surgery in Patients With Glanzmann Thrombasthenia: A Case Series. (28341450)
2017
3
Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B. (28078347)
2017
4
Modeling Glanzmann thrombasthenia using patient specific iPSCs and restoring platelet aggregation function by CD41 overexpression. (28232155)
2017
5
Glanzmann thrombasthenia platelets compete with transfused platelets, reducing the haemostatic impact of platelet transfusions. (28466602)
2017
6
Endometriosis and GlanzmannA9s thrombasthenia. (27655515)
2016
7
No genetic abnormalities identified in I+2IIb and I^3: phenotype overcomes genotype in Glanzmann thrombasthenia. (27808476)
2016
8
Emergency craniotomy in Glanzmann thrombasthenia: Anesthetic management and brief review of literature. (28096593)
2016
9
Perioperative ROTEM and ROTEMplatelet monitoring in a case of Glanzmann's thrombasthenia. (26825624)
2016
10
Simultaneous occurrence of intussusception and duodenal haematoma in a patient with Glanzmann's thrombasthenia. (28051053)
2016
11
Immunisation against I+IIbI^3 and I+vI^3 in a type 1 variant of Glanzmann's thrombasthenia caused by a missense mutation Gly540Asp on I^3. (27098940)
2016
12
Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia. (26452979)
2016
13
New Insights Into the Treatment of Glanzmann Thrombasthenia. (26968829)
2016
14
Glanzmann thrombasthenia in a child manifesting after dengue infection. (28050106)
2016
15
Surgical procedures in patients with Glanzmann's thrombasthenia: case series and literature review. (27273143)
2016
16
Linkage disequilibrium amongst ITGA2B and ITGB3 gene variants in patients with Glanzmann thrombasthenia confirms that most disease-causing mutations are recent. (27469266)
2016
17
Total Extraction as a Treatment for Anaemia in a Patient of Glanzmann's Thrombasthenia with Chronic Gingival Bleed: Case Report. (26894187)
2016
18
Glanzmann thrombasthenia in pregnancy: Optimising maternal and fetal outcomes. (27829878)
2016
19
Efficacy of tranexamic acid for the prevention of bleeding in patients with von Willebrand disease and Glanzmann thrombasthenia: a controlled, before and after trial. (27478149)
2016
20
Is there a role for antiangiogenic therapy, bevacizumab, in the treatment of recurrent digestive bleeding due to angiodysplasia in Glanzmann's thrombasthenia? (27352634)
2016
21
Glanzmann Thrombasthenia: A Clinicopathological Profile. (27539755)
2016
22
Identification and Characterization of Glanzmann Thrombasthenia in 2 Closely Related Mixed-breed Dogs. (26764135)
2016
23
Successful management of perioperative hemostasis in a patient with Glanzmann thrombasthenia who underwent a right total mastectomy. (27696190)
2016
24
The Use of Ankaferd Blood Stopper in a Child With Glanzmann Thrombasthenia With Gingival Bleeding. (26207779)
2015
25
Acute Epidural Hematoma Following Acute Subdural Hematoma Evacuation in a Child With Glanzmann Thrombasthenia. (26421897)
2015
26
Live birth following an intracytoplasmic sperm injection in a patient with Glanzmann thrombasthenia. (26466915)
2015
27
Second trimester prenatal diagnosis in Glanzmann's Thrombasthenia. (26709505)
2015
28
Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options. (26185478)
2015
29
Glanzmann thrombasthenia in Pakistan: molecular analysis and identification of novel mutations. (26096001)
2015
30
Novel mutations of integrin I+IIb and I^3 genes in Turkish children with Glanzmann's thrombasthenia. (25734216)
2015
31
I+IIbI^3 variants defined by next-generation sequencing: Predicting variants likely to cause Glanzmann thrombasthenia. (25827233)
2015
32
Glanzmann's Thrombasthenia Diagnosed following Knee Arthroscopy. (26000186)
2015
33
Long-term therapy with bevacizumab in a patient with Glanzmann's thrombasthenia and recurrent digestive bleeding due to gastrointestinal angiodysplastic lesions. (25646919)
2015
34
Successful use of recombinant factor VIIa in a patient with acquired Glanzmann thrombasthenia. (25471665)
2015
35
Erratum to: A novel ELISA for diagnosis of Glanzmann's thrombasthenia and the heterozygote carriers. (25911135)
2015
36
The international, prospective Glanzmann Thrombasthenia Registry: treatment modalities and outcomes of non-surgical bleeding episodes in patients with Glanzmann thrombasthenia. (26001793)
2015
37
Stem Cell Transplant in Severe Glanzmann Thrombasthenia in an Adult Patient. (26134714)
2015
38
Abnormal cytoplasmic extensions associated with active I+IIbI^3 are probably the cause for macrothrombocytopenia in Glanzmann thrombasthenia-like syndrome. (25806962)
2015
39
The international, prospective Glanzmann Thrombasthenia Registry: treatment and outcomes in surgical intervention. (26001792)
2015
40
Successful Treatment of Refractory Gastrointestinal Bleeding by Systemic (Oral) Ankaferd Blood Stopper in a Patient with Glanzmann Thrombasthenia. (26167349)
2015
41
Glanzmann's thrombasthenia: a rare case of spontaneous bilateral hemotympanum. (25613489)
2015
42
Glanzmann's thrombasthenia: meeting the anticoagulation challenge. (25939445)
2015
43
Expanding the Mutation Spectrum Affecting I+IIbI^3 Integrin in Glanzmann Thrombasthenia: Screening of the ITGA2B and ITGB3 Genes in a Large International Cohort. (25728920)
2015
44
Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia. (26290457)
2015
45
NovoSeven (recombinant factor VIIa) for the treatment of bleeding episodes and perioperative management in patients with Glanzmann's thrombasthenia. (25387838)
2014
46
Spontaneous hemarthrosis in combined Glanzmann thrombasthenia and type 2N von Willebrand disease. (24418945)
2014
47
Coincidence of Glanzmann's thrombasthenia with hereditary haemorrhagic telengiectasia in a man with gastrointestinal bleeding. (25083772)
2014
48
Hematological and surgical management in Glanzmann's thrombasthenia: a case report. (24739923)
2014
49
Phosphatidylserine exposure, microparticle formation and mitochondrial depolarisation in Glanzmann thrombasthenia platelets. (24477274)
2014
50
Use of allogeneic stem cell transplantation for moderate-severe Glanzmann thrombasthenia. (25548835)
2014

Variations for Thrombasthenia

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Expression for genes affiliated with Thrombasthenia

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Search GEO for disease gene expression data for Thrombasthenia.

Pathways for genes affiliated with Thrombasthenia

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Pathways related to Thrombasthenia according to GeneCards Suite gene sharing:

(show all 41)
idSuper pathwaysScoreTop Affiliating Genes
19.5ITGA2B, ITGB3
29.5ITGA2B, ITGB3
39.5ITGA2B, ITGB3
49.5ITGA2B, ITGB3
59.5ITGA2B, ITGB3
69.3ITGB3, VTN
7
Show member pathways
9.3ITGB3, VTN
89.3ITGB3, VTN
99.2ITGA2, ITGA2B
109.2ITGA2, ITGA2B
11
Show member pathways
9.0F2, ITGA2B, ITGB3
128.7ITGA2, ITGA2B, ITGB3
138.7ITGA2, ITGA2B, ITGB3
14
Show member pathways
8.7ITGA2, ITGA2B, ITGB3
15
Show member pathways
8.7ITGA2, ITGA2B, ITGB3
168.7ITGA2, ITGA2B, ITGB3
178.7ITGA2, ITGA2B, ITGB3
18
Show member pathways
8.7ITGA2, ITGA2B, ITGB3
19
Show member pathways
8.7ITGA2, ITGA2B, ITGB3
20
Show member pathways
8.7ITGA2, ITGA2B, ITGB3
21
Show member pathways
8.7ITGA2, ITGA2B, ITGB3
22
Show member pathways
8.7ITGA2, ITGA2B, ITGB3
238.7ITGA2, ITGA2B, ITGB3
248.7ITGA2, ITGA2B, ITGB3
25
Show member pathways
8.7ITGA2, ITGA2B, ITGB3
26
Show member pathways
8.5ITGA2, ITGB3, VTN
278.5ITGA2, ITGB3, VTN
28
Show member pathways
8.5ITGA2, ITGB3, VTN
298.5ITGA2, ITGB3, VTN
30
Show member pathways
8.2F2, ITGA2, ITGA2B, ITGB3
31
Show member pathways
8.2F2, ITGA2, ITGA2B, ITGB3
32
Show member pathways
8.2F2, ITGA2, ITGA2B, ITGB3
338.2F2, ITGA2, ITGA2B, ITGB3
34
Show member pathways
8.2F2, ITGA2, ITGA2B, ITGB3
358.1ITGA2, ITGA2B, ITGB3, VTN
368.1ITGA2, ITGA2B, ITGB3, VTN
37
Show member pathways
8.1ITGA2, ITGA2B, ITGB3, VTN
38
Show member pathways
8.1ITGA2, ITGA2B, ITGB3, VTN
398.1ITGA2, ITGA2B, ITGB3, VTN
40
Show member pathways
8.1ITGA2, ITGA2B, ITGB3, VTN
41
Show member pathways
7.5F2, ITGA2, ITGA2B, ITGB3, VTN

GO Terms for genes affiliated with Thrombasthenia

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Cellular components related to Thrombasthenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1alphav-beta3 integrin-vitronectin complexGO:007106210.1ITGB3, VTN
2Golgi lumenGO:00057969.8F2, VTN
3blood microparticleGO:00725629.6F2, ITGA2B, VTN
4platelet alpha granule membraneGO:00310929.5ITGA2B, ITGB3
5cell surfaceGO:00099869.4ITGA2, ITGA2B, ITGB3
6external side of plasma membraneGO:00098979.3F2, ITGA2, ITGA2B
7focal adhesionGO:00059259.2ITGA2, ITGA2B, ITGB3
8integrin complexGO:00083059.0ITGA2, ITGA2B, ITGB3

Biological processes related to Thrombasthenia according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1platelet aggregationGO:007052710.2ITGA2B, ITGB3
2platelet degranulationGO:000257610.1ITGA2B, ITGB3
3platelet activationGO:003016810.1F2, ITGB3
4positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.0ITGB3, VTN
5positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:00309499.9ITGB3, VTN
6regulation of complement activationGO:00304499.9F2, VTN
7positive regulation of leukocyte migrationGO:00026879.8ITGA2, ITGA2B
8cell-substrate adhesionGO:00315899.8ITGA2, ITGB3
9mesodermal cell differentiationGO:00483339.8ITGA2, ITGB3
10positive regulation of collagen biosynthetic processGO:00329679.8F2, ITGA2
11viral entry into host cellGO:00467189.7ITGA2, ITGB3
12positive regulation of smooth muscle cell migrationGO:00149119.6ITGA2, VTN
13integrin-mediated signaling pathwayGO:00072299.4ITGA2, ITGA2B, ITGB3
14blood coagulationGO:00075969.3F2, ITGA2, ITGB3
15cell adhesion mediated by integrinGO:00336279.2ITGA2, ITGB3, VTN
16wound healingGO:00420609.1ITGA2, ITGB3
17cell adhesionGO:00071558.8ITGA2, ITGA2B, ITGB3, VTN
18cell-matrix adhesionGO:00071608.8ITGA2, ITGA2B, ITGB3, VTN
19extracellular matrix organizationGO:00301988.7ITGA2, ITGA2B, ITGB3, VTN

Molecular functions related to Thrombasthenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen bindingGO:00055189.6ITGA2, VTN
2integrin bindingGO:00051789.5ITGA2, VTN
3extracellular matrix bindingGO:00508409.5ITGA2B, ITGB3, VTN
4virus receptor activityGO:00016189.1ITGA2, ITGB3

Sources for Thrombasthenia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet