TAO
MCID: THR006
MIFTS: 75

Thromboangiitis Obliterans (TAO) malady

Cardiovascular diseases, Nephrological diseases, Bone diseases, Blood diseases categories

Summaries for Thromboangiitis Obliterans

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Sources:
42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Buerger disease is a disease that causes obstruction of the blood vessels of the hands and feet. it is caused by vasculitis, which is an inflammation of blood vessels. the blood vessels of the hands and feet are especially affected, becoming constricted or totally blocked. this reduces blood flow to the tissues of hands and feet, resulting in pain and eventually damage. last updated: 11/19/2009

MalaCards: Thromboangiitis Obliterans, also known as buerger disease, is related to arteriosclerosis obliterans and arteriosclerosis, and has symptoms including acute ischemia of the lower limbs, arterial pulse abolition and arterial embolism/thrombosis. An important gene associated with Thromboangiitis Obliterans is SELE (selectin E), and among its related pathways are Adhesion and LDL Oxidation in Atherogenesis. The drugs isoxsuprine and isoxsuprine hydrochloride and the compounds norepinephrine and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and endothelial, and related mouse phenotypes are respiratory system and cardiovascular system.

Wikipedia:63 Thromboangiitis obliterans (also known as Buerger\'s disease, Buerger disease [English /bʌrɡər/;... more...

Description from OMIM:46 211480

Aliases & Classifications for Thromboangiitis Obliterans

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 44Novoseek, 46OMIM, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

48
thromboangiitis obliterans:
Prevalence: 1-5/10000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

thromboangiitis obliterans 8 42 48 30 60
buerger disease 42 44 48 46
buerger's disease 8 42
inflammatory occlusive peripheral vascular disease 42
occlusive peripheral vascular disease 42
thromboangiitis obliterans nos 8
presenile gangrene 8
tao 42


External Ids:

Disease Ontology8 DOID:12918
MeSH34 D013919
OMIM46 211480
NCIt39 C35070
ICD9CM27 443.1
SNOMED-CT via Orphanet57 52403007
ICD10 via Orphanet26 I73.1
ICD1025 I73.1

Related Diseases for Thromboangiitis Obliterans

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17GeneCards, 18GeneDecks
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Diseases related to Thromboangiitis Obliterans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis obliterans30.9ICAM1, VCAM1
2arteriosclerosis30.9SERPINE1, VCAM1, NOS3, EDN1, ICAM1
3ischemia30.8SELE, NOS3, PLAT, EDN1, ICAM1
4vascular disease30.7SERPINE1, SELE, VCAM1, NOS3, PLAT, MMP9
5thrombophlebitis30.7APOH
6atherosclerosis30.7SERPINE1, SELE, VCAM1, NOS3, PLAT, MMP9
7vasculitis30.4SERPINB1, SELE, VCAM1, APOH, ICAM1
8coronary artery disease30.4ICAM1, EDN1, MMP9, PLAT, NOS3, VCAM1
9dilated cardiomyopathy30.2EDN1
10carotid artery thrombosis30.2SERPINE1
11peripheral vascular disease30.2VCAM1, SELE, SERPINE1
12impotence30.2EDN1, NOS3
13pulmonary embolism30.2APOH, PLAT
14ischemic heart disease30.2EDN1, PLAT, NOS3, SERPINE1
15thrombophilia30.2APOH, PLAT, SELE, SERPINE1
16arthritis30.2TIMP1, ICAM1, MMP9, SELE
17hyperhomocysteinemia30.2SERPINE1, SELE, VCAM1, NOS3, PLAT, APOH
18obesity29.9SERPINE1, SELE, NOS3, HTR2A
19diabetes mellitus29.9ICAM1, EDN1, MMP9, PLAT, NOS3, VCAM1
20cerebritis10.7
21intestinal disease10.4
22critical limb ischemia10.3
23spinal cord disease10.3
24splenic disease10.3
25thyroiditis10.3
26aortic disease10.2
27paronychia10.2
28cellulitis10.2
29nicotine dependence10.2
30blood platelet disease10.2
31colonic disease10.2
32diarrhea10.2
33eosinophilia10.2
34phlebitis10.2
35vein disease10.2
36venous insufficiency10.2
37compartment syndrome10.0
38intermittent claudication10.0HTR2A
39dementia10.0HTR2A
40cystic fibrosis10.0HTR2A
41coronary stenosis10.0HTR2A
42glaucoma10.0EDN1
43alpha 1-antitrypsin deficiency10.0SERPINB1
44inflammatory bowel disease10.0ICAM1
45sarcoidosis10.0ICAM1
46intracranial aneurysm10.0NOS3
47systemic scleroderma10.0EDN1
48pancreatitis10.0ICAM1
49primary pulmonary hypertension10.0EDN1
50malaria10.0ICAM1

Graphical network of the top 20 diseases related to Thromboangiitis Obliterans:



Diseases related to thromboangiitis obliterans

Clinical Features for Thromboangiitis Obliterans

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

211480

Clinical synopsis from OMIM:

211480

Symptoms:

48 (show all 12)
  • acute ischemia of the lower limbs
  • arterial pulse abolition
  • arterial embolism/thrombosis
  • articular/joint pain/arthralgia
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • chronic skin infection/ulcerations/ulcers/cancrum
  • sensitive trouble/deficit
  • gangrena/necrosis
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • vascularitis/vasculitides/arteritis
  • insomnia
  • hyperhidrosis/increased sweating

Drugs & Therapeutics for Thromboangiitis Obliterans

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Thromboangiitis Obliterans

Drug clinical trials:

Search ClinicalTrials for Thromboangiitis Obliterans

Search NIH Clinical Center for Thromboangiitis Obliterans

Search CenterWatch for Thromboangiitis Obliterans

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Thromboangiitis Obliterans cell therapies at LifeMap Discovery.

Genetic Tests for Thromboangiitis Obliterans

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Anatomical Context for Thromboangiitis Obliterans

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Thromboangiitis Obliterans:

32
Bone, Skin, Endothelial, Bone marrow, Colon, Spinal cord, Heart, Kidney

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Thromboangiitis Obliterans:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Thromboangiitis Obliterans or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thromboangiitis Obliterans:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8NOS3, SERPINB1, MMP9
2MP:00053858.8VCAM1, NOS3, EDN1, TIMP1, SELE
3MP:00053698.4ICAM1, HTR2A, MMP9, NOS3
4MP:00053817.8MMP9, ICAM1, HTR2A, EDN1, NOS3, PLAT
5MP:00053786.9SERPINE1, TIMP1, SELE, VCAM1, PLAT, NOS3
6MP:00053976.5SERPINE1, VCAM1, NOS3, PLAT, MMP9, ICAM1
7MP:00053876.5PLAT, SERPINB1, SERPINE1, SELE, VCAM1, NOS3
8MP:00053765.7SERPINB1, SERPINE1, SELE, VCAM1, NOS3, PLAT
9MP:00107685.7SELE, VCAM1, NOS3, PLAT, ICAM1, APOH

Publications for Thromboangiitis Obliterans

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Sources:
50PubMed
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Articles related to Thromboangiitis Obliterans:

(show top 50)    (show all 297)
idTitleAuthorsYear
1
Thromboangiitis obliterans successfully treated with phosphodiesterase type 5 inhibitors. (24000082)
2013
2
Thromboangiitis obliterans in two brothers. (24137181)
2013
3
Activation of cytokines corroborate with development of inflammation and autoimmunity in thromboangiitis obliterans patients. (22943198)
2012
4
Management of thromboangiitis obliterans using distraction osteogenesis: A retrospective study. (22912529)
2012
5
Color doppler flows of corkscrew collaterals in Thromboangiitis obliterans (Buerger's disease) using color duplex ultrasonography. (21679855)
2011
6
Abnormal plasma fibrin clot characteristics are associated with worse clinical outcome in patients with peripheral arterial disease and thromboangiitis obliterans. (21324459)
2011
7
Stem cell therapy in patients with thromboangiitis obliterans: assessment of the long-term clinical outcome and analysis of the prognostic factors. (24298340)
2011
8
Commentary: Miyamoto K, Nishigami K, Nagaya N, et al. Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangiitis obliterans. Circulation. 2006;114: 2679-2684. (18403473)
2008
9
Thromboangiitis obliterans (Buerger's disease): searching for a therapeutic strategy. (17351161)
2007
10
One of the most frequent vascular diseases in northeastern of Turkey: Thromboangiitis obliterans or Buerger's disease (experience with 344 cases). (16580754)
2006
11
Intrarenal arterial stenosis in a patient with thromboangiitis obliterans. (16984562)
2006
12
Cerebral angiographic findings in thromboangiitis obliterans. (16133479)
2005
13
Steroid-responsive thromboangiitis obliterans. (15380972)
2004
14
Thromboangiitis obliterans (Buerger disease) in a female mild smoker treated with spinal cord stimulation. (15201654)
2004
15
Long-term survival and amputation risk in thromboangiitis obliterans (Buerger's disease). (15607407)
2004
16
Treatment of patients with thromboangiitis obliterans with cyclophosphamide. (11437030)
2001
17
Factors affecting the long-term outcome of Buerger's disease (thromboangiitis obliterans). (10392482)
1999
18
Is the capillary microscopic determination of the visible capillary length a diagnostic criterion in thromboangiitis obliterans? (9612111)
1998
19
Thromboangiitis obliterans (Buerger's disease) in visceral vessels confirmed by angiographic and histological findings. (9854560)
1998
20
Thromboangiitis obliterans (Buerger's disease) with intestinal involvement--a case report. (9631896)
1998
21
Oral iloprost in the treatment of thromboangiitis obliterans (Buerger's disease): a double-blind, randomised, placebo-controlled trial. The European TAO Study Group. (9610341)
1998
22
Transcranial Doppler velocities in patients with thromboangiitis obliterans. (9194540)
1997
23
Images in vascular medicine. Buerger's disease (thromboangiitis obliterans). (9546927)
1996
24
Multiple organ manifestations in thromboangiitis obliterans (Buerger's disease). A case report. (8619517)
1996
25
Buerger's disease (thromboangiitis obliterans). (2189162)
1990
26
Trial of iloprost versus aspirin treatment for critical limb ischaemia of thromboangiitis obliterans. The TAO Study. (1689791)
1990
27
Intraoral manifestation of thromboangiitis obliterans (Buerger's disease). (2304748)
1990
28
Serum zinc and copper in patients with atherosclerosis and thromboangiitis obliterans. (2484753)
1989
29
Studies on hypercoagulation state in thromboangiitis obliterans. (2504556)
1989
30
Thromboangiitis obliterans (Buerger's disease) and smokeless tobacco. (3382454)
1988
31
Study of the factors affecting blood viscosity in patients with thromboangiitis obliterans. A preliminary report. (3373617)
1988
32
Thromboangiitis obliterans (Buerger's disease) and smokeless tobacco. (3663253)
1987
33
Thromboangiitis obliterans associated with idiopathic hypereosinophilia. (4026503)
1985
34
CAT scan and immunohistochemical findings in a case of cerebral thromboangiitis obliterans (Buerger's disease). (6714279)
1984
35
Buerger's disease (thromboangiitis obliterans): an analysis of the arteriograms of 119 cases. (7067357)
1982
36
Autoimmunological aspects of thromboangiitis obliterans (Buerger's disease). (367656)
1978
37
The angiographic appearance of thromboangiitis obliterans (Buerger's disease) in the abdominal visceral vessels. (4715156)
1973
38
Disease of the mesenteric circulation in patients with thromboangiitis obliterans. (4540575)
1972
39
Treatment of thromboangiitis obliterans with clofibrate (Atromid-S). (5656796)
1968
40
THROMBOANGIITIS OBLITERANS (BUERGER'S DISEASE). (14146982)
1964
41
Viral etiology in cardiovascular affections. IV. Experimental and histopathological study of some cases of rickettsial thromboangiitis obliterans. (13938413)
1962
42
The function and morphology of the kidney in thromboangiitis obliterans. (13822632)
1959
43
Thromboangiitis obliterans: a 30-year study. (13502019)
1958
44
Haemorrhagic infarction of the sigmoid as a result of thromboangiitis obliterans. (13596172)
1958
45
Thromboangiitis obliterans in a female. (13509222)
1957
46
Mental disorders in thromboangiitis obliterans]. (13227542)
1954
47
STAFF CONFERENCE, Thayer Veterans Administration Hospital: disseminated thromboangiitis obliterans. (13097577)
1953
48
Thromboangiitis obliterans in women. (13090451)
1953
49
Treatment of thromboangiitis obliterans; 2-year follow-up after sympathectomy. (18110730)
1949
50
Sympathectomy in the treatment of thromboangiitis obliterans. (18899841)
1948

Genetic Variations for Thromboangiitis Obliterans

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Expression for genes affiliated with Thromboangiitis Obliterans

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thromboangiitis Obliterans

Search GEO for disease gene expression data for Thromboangiitis Obliterans.

Pathways for genes affiliated with Thromboangiitis Obliterans

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Sources:
4Cell Signaling Technology, 51QIAGEN, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore
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Pathways related to Thromboangiitis Obliterans according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8VCAM1, ICAM1
29.8ICAM1, VCAM1
39.6SERPINE1, PLAT
49.6SELE, VCAM1, ICAM1
59.6SELE, VCAM1, ICAM1
6
Hide members
9.4SERPINE1, VCAM1, ICAM1
79.3MMP9, NOS3
89.2MMP9, PLAT
99.2ICAM1, PLAT, SERPINE1
10
Hide members
9.2ICAM1, NOS3, VCAM1, SELE
11
Hide members
9.0PLAT, NOS3, SELE, SERPINE1
129.0VCAM1, MMP9, ICAM1
138.9PLAT, MMP9, ICAM1
148.7SERPINE1, NOS3, EDN1, TIMP1
158.7NOS3, MMP9, TIMP1
16
Hide members
8.5SERPINE1, VCAM1, MMP9, ICAM1
178.4SELE, VCAM1, MMP9, EDN1, ICAM1
18
Cell adhesion ECM remodeling
Hide members
8.2TIMP1, MMP9, PLAT, SERPINE1
19
Hide members
7.5ICAM1, HTR2A, EDN1, MMP9, PLAT, VCAM1

Compounds for genes affiliated with Thromboangiitis Obliterans

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Thromboangiitis Obliterans according to GeneCards/GeneDecks:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.5HTR2A
2cyclophosphamide44 49 1112.0APOH, NOS3
3rosiglitazone44 49 28 11 2414.0TIMP1, VCAM1
4aspartate449.9SELE, VCAM1
5matrigel449.9NOS3, SERPINE1, SELE
6pge2449.7MMP9
7carvedilol44 49 28 1112.6VCAM1, NOS3, EDN1, SELE
8nebivolol44 1110.6NOS3, SERPINE1, EDN1
9gliclazide44 49 1111.5SELE, VCAM1, PLAT, ICAM1
10iloprost44 59 28 1112.5SELE, VCAM1, PLAT, EDN1
11polymyxin b449.4SERPINE1, ICAM1, SELE, VCAM1
12quinapril44 1110.4PLAT, SERPINE1, SELE, EDN1
13losartan44 49 28 1112.4EDN1, PLAT, SELE, SERPINE1
14apocynin44 5910.3SELE, EDN1, NOS3, ICAM1, VCAM1
15heparin44 28 11 2412.1SELE, VCAM1, APOH, TIMP1
16pravastatin44 49 28 11 2413.1SERPINE1, SELE, VCAM1, NOS3, ICAM1
17sodium nitroprusside449.0SERPINE1, EDN1, PLAT, NOS3, VCAM1
18hirudin449.0TIMP1, PLAT, SERPINE1, SELE
19isoproterenol44 119.9SELE, SERPINE1, VCAM1, PLAT, EDN1
20l-nmma448.8EDN1, MMP9, NOS3, VCAM1
21endotoxin448.8ICAM1, APOH, VCAM1, SELE, SERPINE1
22ciglitazone44 289.8MMP9, NOS3, ICAM1, SERPINE1
23omapatrilat448.8PLAT, MMP9, EDN1
24homocysteine44 249.6APOH, SERPINE1, SELE, PLAT, NOS3, VCAM1
25creatinine448.6MMP9, SELE, APOH
26histamine44 28 2410.5ICAM1, TIMP1, EDN1, PLAT, VCAM1, SELE
27fenofibrate44 49 1110.4SERPINE1, ICAM1, MMP9, NOS3, VCAM1, SELE
28cytochalasin d44 599.4VCAM1, MMP9, ICAM1, SELE, TIMP1
29nicotine44 49 28 1111.3ICAM1, SERPINE1, MMP9, PLAT, SELE
30troglitazone44 28 59 1111.3MMP9, SERPINE1, VCAM1, PLAT, SELE, ICAM1
31aspirin44 49 28 2411.3SELE, TIMP1, APOH, PLAT, NOS3, SERPINE1
32nifedipine44 49 28 1111.3SERPINE1, MMP9, SELE, EDN1, TIMP1
33herbimycin a44 599.2EDN1, MMP9, VCAM1, SELE, ICAM1, TIMP1
34folate448.0NOS3, VCAM1, SELE, APOH, TIMP1, MMP9
35fluvastatin44 49 28 1111.0SERPINE1, SELE, VCAM1, NOS3, PLAT, MMP9
36simvastatin44 49 59 28 11 2413.0PLAT, NOS3, VCAM1, SELE, SERPINE1, MMP9
37methotrexate44 49 119.8SERPINE1, SELE, NOS3, MMP9, APOH, TIMP1
38fibrinogen447.8PLAT, SELE, MMP9, ICAM1, APOH, VCAM1
39ly294002447.7MMP9, TIMP1, ICAM1, SERPINE1, NOS3, VCAM1
40nitric oxide44 11 249.7VCAM1, SELE, NOS3, APOH, ICAM1, EDN1
41pd 98,059447.7ICAM1, EDN1, MMP9, TIMP1, NOS3, VCAM1
42lactate447.6TIMP1, APOH, MMP9, VCAM1, SELE, ICAM1
438-isoprostane447.5SERPINE1, SELE, VCAM1, NOS3, MMP9, EDN1
44sb 20358044 598.4ICAM1, SERPINE1, TIMP1, SELE, VCAM1, NOS3
45genistein44 28 59 2 11 2412.4ICAM1, SERPINE1, NOS3, TIMP1, SELE, EDN1
46phosphatidylinositol447.4NOS3, MMP9, VCAM1, EDN1, ICAM1, TIMP1
47prostacyclin447.3SERPINE1, SELE, VCAM1, NOS3, PLAT, EDN1
48actinomycin d447.3SELE, SERPINE1, TIMP1, ICAM1, EDN1, MMP9
49atorvastatin44 49 28 11 2411.0ICAM1, NOS3, VCAM1, SELE, PLAT, MMP9
50vegf446.9VCAM1, ICAM1, TIMP1, MMP9, APOH, EDN1

GO Terms for genes affiliated with Thromboangiitis Obliterans

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16Gene Ontology
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Cellular components related to Thromboangiitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1caveolaGO:0059019.3HTR2A, NOS3, SELE
2extracellular matrixGO:0310129.1SERPINE1, PLAT, APOH
3extracellular spaceGO:0056156.4SERPINB1, ICAM1, APOH, EDN1, MMP9, PLAT

Biological processes related to Thromboangiitis Obliterans according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:05090110.1SELE, VCAM1
2regulation of systemic arterial blood pressure by endothelinGO:00310010.1NOS3, EDN1
3membrane to membrane dockingGO:02261410.1ICAM1, VCAM1
4negative regulation of potassium ion transportGO:04326710.0HTR2A, NOS3
5negative regulation of calcium ion transportGO:0519269.9NOS3, ICAM1
6negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.9NOS3, SERPINE1
7negative regulation of smooth muscle cell apoptotic processGO:0343929.9APOH, EDN1
8leukocyte cell-cell adhesionGO:0071599.9ICAM1, VCAM1, SELE
9heterophilic cell-cell adhesionGO:0071579.9VCAM1, ICAM1, SELE
10phosphatidylinositol 3-kinase cascadeGO:0140659.8EDN1, HTR2A
11plasminogen activationGO:0316399.8APOH, PLAT
12negative regulation of fibrinolysisGO:0519189.7APOH, SERPINE1
13fibrinolysisGO:0427309.6PLAT, SERPINE1
14positive regulation of blood coagulationGO:0301949.6APOH, SERPINE1
15agingGO:0075689.5TIMP1, HTR2A, VCAM1
16positive regulation of vasoconstrictionGO:0459079.5ICAM1, HTR2A
17negative regulation of blood coagulationGO:0301959.5APOH, SERPINE1, EDN1
18response to hypoxiaGO:0016669.3VCAM1, EDN1, PLAT
19blood coagulationGO:0075968.7TIMP1, PLAT, NOS3, SELE, SERPINE1

Molecular functions related to Thromboangiitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.3SERPINE1, SELE, NOS3, PLAT, MMP9, EDN1

Products for genes affiliated with Thromboangiitis Obliterans

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  • Antibodies
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Sources for Thromboangiitis Obliterans

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet