MCID: THR006
MIFTS: 68

Thromboangiitis Obliterans malady

Rare diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases, Blood diseases categories

Aliases & Classifications for Thromboangiitis Obliterans

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 48Orphanet, 61UMLS, 56SNOMED-CT, 33MeSH, 39NCIt, 27ICD9CM, 26ICD10 via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Thromboangiitis Obliterans:

Name: Thromboangiitis Obliterans 30 8 42 48 61
Buerger Disease 42 44 48
Buerger's Disease 8 42
Inflammatory Occlusive Peripheral Vascular Disease 42
 
Occlusive Peripheral Vascular Disease 42
Thromboangiitis Obliterans Nos 8
Presenile Gangrene 8
Tao 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
thromboangiitis obliterans:
Prevalence: 1-5/10000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Disease Ontology8 DOID:12918
MeSH33 D013919
NCIt39 C35070
ICD9CM27 443.1
Orphanet48 36258
ICD10 via Orphanet26 I73.1
ICD1025 I73.1

Summaries for Thromboangiitis Obliterans

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NIH Rare Diseases:42 Buerger disease is a disease that causes obstruction of the blood vessels of the hands and feet. it is caused by vasculitis, which is an inflammation of blood vessels. the blood vessels of the hands and feet are especially affected, becoming constricted or totally blocked. this reduces blood flow to the tissues of hands and feet, resulting in pain and eventually damage. last updated: 11/19/2009

MalaCards based summary: Thromboangiitis Obliterans, also known as buerger disease, is related to thrombophlebitis and vascular disease, and has symptoms including vasculitis, arterial thrombosis and gangrene. An important gene associated with Thromboangiitis Obliterans is APOH (apolipoprotein H (beta-2-glycoprotein I)), and among its related pathways are Development Leptin signaling via JAK STAT and MAPK cascades and Endothelin. The drugs tolazoline and tolazoline hydrochloride and the compounds carvedilol and gliclazide have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and endothelial, and related mouse phenotypes are endocrine/exocrine gland and vision/eye.

Wikipedia:64 Thromboangiitis obliterans (also known as Buerger\'s disease, Buerger disease [English /b?r??r/; German... more...

Related Diseases for Thromboangiitis Obliterans

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Diseases related to Thromboangiitis Obliterans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophlebitis31.6APOH
2vascular disease31.4TIMP1, APOH
3arteriosclerosis obliterans31.3VCAM1, ICAM1
4peripheral vascular disease31.0SELE
5impotence30.7NOS3, EDN1
6arteriosclerosis30.6EDN1, ICAM1, VCAM1, NOS3, SERPINE1
7pulmonary embolism30.5APOH, PLAT
8vasculitis30.4VCAM1, APOH, SELE, ICAM1, SERPINB1
9ischemia30.3NOS3, EDN1, SELE, ICAM1, PLAT
10arthritis30.2TIMP1, SELE, MMP9, ICAM1
11thrombophilia30.1PLAT, SELE, SERPINE1, APOH
12obesity29.9SERPINE1, NOS3, HTR2A, SELE
13hyperhomocysteinemia29.8PLAT, NOS3, VCAM1, SERPINE1, APOH, SELE
14atherosclerosis28.8ICAM1, EDN1, APOH, SELE, TIMP1, PLAT
15cerebritis10.7
16endotheliitis10.6
17retinal artery occlusion10.5APOH
18retinal vein occlusion10.5APOH
19carotid artery thrombosis10.4SERPINE1
20systemic scleroderma10.4EDN1
21heart valve disease10.4HTR2A, APOH
22critical limb ischemia10.4
23limb ischemia10.4
24peripheral artery disease10.4
25artery disease10.4
26malaria10.3ICAM1
27allergic rhinitis10.3VCAM1, SELE
28diabetic angiopathy10.3EDN1, SELE
29acute chest syndrome10.3NOS3, VCAM1
30thyroiditis10.3
31plummer's disease10.3ICAM1, SELE
32cardiac rupture10.3PLAT
33central retinal artery occlusion10.3PLAT
34protein s deficiency10.3SERPINE1, APOH
35prinzmetal's variant angina10.3NOS3, EDN1
36hellp syndrome10.3APOH, SERPINE1
37henoch-schoenlein purpura10.3ICAM1, VCAM1
38inclusion body myositis10.3VCAM1, ICAM1
39portal hypertension10.3EDN1, NOS3
40wegener granulomatosis10.3SERPINB1, SELE
41allergic contact dermatitis10.2ICAM1, SELE
42protein c deficiency10.2APOH, SERPINE1
43hepatopulmonary syndrome10.2EDN1, NOS3
44oral lichen planus10.2ICAM1, VCAM1
45behcet's disease10.2SELE, APOH
46dilated cardiomyopathy10.2
47ischemic heart disease10.2
48cryoglobulinemia10.2
49chronic venous insufficiency10.2
50thrombotic thrombocytopenic purpura10.2

Graphical network of the top 20 diseases related to Thromboangiitis Obliterans:



Diseases related to thromboangiitis obliterans

Symptoms for Thromboangiitis Obliterans

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Symptoms:

 48 (show all 12)
  • chronic skin infection/ulcerations/ulcers/cancrum
  • arterial embolism/thrombosis
  • arterial pulse abolition
  • vascularitis/vasculitides/arteritis
  • gangrena/necrosis
  • sensitive trouble/deficit
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • acute ischemia of the lower limbs
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • articular/joint pain/arthralgia
  • hyperhidrosis/increased sweating
  • insomnia

HPO human phenotypes related to Thromboangiitis Obliterans:

(show all 9)
id Description Frequency HPO Source Accession
1 vasculitis hallmark (90%) HP:0002633
2 arterial thrombosis hallmark (90%) HP:0004420
3 gangrene hallmark (90%) HP:0100758
4 skin ulcer hallmark (90%) HP:0200042
5 acrocyanosis typical (50%) HP:0001063
6 arthralgia typical (50%) HP:0002829
7 paresthesia typical (50%) HP:0003401
8 hyperhidrosis occasional (7.5%) HP:0000975
9 insomnia occasional (7.5%) HP:0100785

Drugs & Therapeutics for Thromboangiitis Obliterans

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Drug clinical trials:

Search ClinicalTrials for Thromboangiitis Obliterans

Search NIH Clinical Center for Thromboangiitis Obliterans

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Thromboangiitis Obliterans cell therapies at LifeMap Discovery.

Genetic Tests for Thromboangiitis Obliterans

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Anatomical Context for Thromboangiitis Obliterans

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MalaCards organs/tissues related to Thromboangiitis Obliterans:

31
Bone, Skin, Endothelial, Bone marrow, Colon, Spinal cord, Heart, Neutrophil, Kidney

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Thromboangiitis Obliterans:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Thromboangiitis Obliterans or affiliated genes

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Publications for Thromboangiitis Obliterans

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Articles related to Thromboangiitis Obliterans:

(show top 50)    (show all 309)
idTitleAuthorsYear
1
Integrated treatment for lower-limb stage II thromboangiitis obliterans by interventional therapy and oral administration of Chinese medicine: a randomized controlled clinical trial. (25842727)
2015
2
Buerger Disease (Thromboangiitis Obliterans). (25770636)
2014
3
The value of FDG-PET in the diagnosis of thromboangiitis obliterans-a case series. (24794493)
2014
4
Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost. (25005765)
2014
5
Temporal artery involvement as the presenting sign of thromboangiitis obliterans. (23519182)
2013
6
Imbalanced matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 activities in patients with thromboangiitis obliterans. (22402936)
2012
7
Buerger's disease (Thromboangiitis obliterans): a diagnostic challenge. (22679237)
2011
8
Buerger's Disease (Thromboangiitis Obliterans)- Management by Ilizarov's Technique of Horizontal Distraction. A Retrospective Study of 60 Cases. (22211037)
2011
9
Effectiveness of bosentan in the treatment of ischemic lesions in a case of thromboangiitis obliterans (Buerger disease): a case report. (21810389)
2011
10
Protective effect of Shenfu injection on thromboangiitis obliterans model rats. (21982791)
2011
11
Color doppler flows of corkscrew collaterals in Thromboangiitis obliterans (Buerger's disease) using color duplex ultrasonography. (21679855)
2011
12
Classification of corkscrew collaterals in thromboangiitis obliterans (Buerger's disease): relationship between corkscrew type and prevalence of ischemic ulcers. (20534945)
2010
13
Thromboangiitis obliterans and endothelial function. (20584171)
2010
14
Treatment of Buerger disease (thromboangiitis obliterans) with bosentan: a case report. (21686681)
2009
15
Thromboangiitis obliterans in the 21st century--a new face of disease. (19269635)
2009
16
A prospective, case-control study of tobacco dependence in thromboangiitis obliterans (Buerger's Disease). (16444459)
2006
17
One of the most frequent vascular diseases in northeastern of Turkey: Thromboangiitis obliterans or Buerger's disease (experience with 344 cases). (16580754)
2006
18
Inflammatory joint disease and severe ischemia of the extremities revealing thromboangiitis obliterans in a female. (15681252)
2005
19
Thromboangiitis obliterans associated with peripheral blood and eosinophilic cellulitis-like skin lesions. (15985040)
2005
20
Involvement of the coronary artery in a patient with thromboangiitis obliterans. A case report. (12181595)
2002
21
Distribution of arterial involvement in thromboangiitis obliterans (Buerger's disease): results of a study conducted by the Intractable Vasculitis Syndromes Research Group in Japan. (10930225)
2000
22
Current status of thromboangiitis obliterans (Buerger's disease) in Japan. (10980360)
2000
23
Implantable spinal cord stimulator to treat the ischemic manifestations of thromboangiitis obliterans (Buerger's disease). (10231644)
1999
24
Study of anti-neutrophil cytoplasmic antibodies in patients with thromboangiitis obliterans (Buerger's disease). (9822265)
1998
25
Is the capillary microscopic determination of the visible capillary length a diagnostic criterion in thromboangiitis obliterans? (9612111)
1998
26
Inpatient treatment of severe nicotine dependence in a patient with thromboangiitis obliterans (Buerger's disease). (9621859)
1998
27
Thromboangiitis obliterans (Buerger's disease) in visceral vessels confirmed by angiographic and histological findings. (9854560)
1998
28
Thromboangiitis obliterans (Buerger's disease). (9189999)
1997
29
Pharmacokinetics and tolerability of oral iloprost in thromboangiitis obliterans patients. (9349930)
1997
30
Thromboangiitis obliterans (Buerger's disease) (9119522)
1996
31
Case of thromboangiitis obliterans (Buerger's disease) of the upper lip. (7573750)
1995
32
Impotence as a cardinal sign in the thromboangiitis obliterans diagnosis. (8608695)
1995
33
Cerebral thromboangiitis obliterans: clinical and MRI findings in a case. (7671993)
1995
34
Thromboangiitis obliterans. (7518238)
1994
35
Buerger's disease (thromboangiitis obliterans). (2189162)
1990
36
Serum zinc and copper in patients with atherosclerosis and thromboangiitis obliterans. (2484753)
1989
37
CAT scan and immunohistochemical findings in a case of cerebral thromboangiitis obliterans (Buerger's disease). (6714279)
1984
38
Cellular sensitivity to collagen in thromboangiitis obliterans. (6835334)
1983
39
Buerger's disease (thromboangiitis obliterans): an analysis of the arteriograms of 119 cases. (7067357)
1982
40
Autoantibodies in thromboangiitis obliterans (Buerger's disease). (6751163)
1982
41
Factors influenced on prognosis of reconstructive surgery for peripheral arterial occlusion: comparative study between arteriosclerosis obliterans and thromboangiitis obliterans. (599159)
1977
42
Traditional chinese medicine in the treatment of thromboangiitis obliterans. Report of 136 cases. (5678364)
1968
43
Coexistence of thromboangiitis obliterans and arteriosclerosis: relationship to smoking. (5914684)
1966
44
Thromboangiitis obliterans and arteriosclerosis obliterans. (5833515)
1965
45
THROMBOANGIITIS OBLITERANS AND ARTERIOSCLEROSIS OBLITERANS. CLINICAL AND PROGNOSTIC DIFFERENCES. (14065946)
1963
46
Cogan's syndrome and systemic vascular disease. Analysis of pathologic features with reference to its relationship to thromboangiitis obliterans (Buerger). (13893233)
1961
47
Thromboangiitis obliterans: a 30-year study. (13502019)
1958
48
A follow-up study of patient with thromboangiitis obliterans (Buerger's disease). (15395864)
1949
49
Cerebral thromboangiitis obliterans. (20289123)
1947
50
Treatment of thromboangiitis obliterans. (21006071)
1945

Variations for Thromboangiitis Obliterans

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Expression for genes affiliated with Thromboangiitis Obliterans

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Search GEO for disease gene expression data for Thromboangiitis Obliterans.

Pathways for genes affiliated with Thromboangiitis Obliterans

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Pathways related to Thromboangiitis Obliterans according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8EDN1, TIMP1
29.7EDN1, NOS3
39.7VCAM1, ICAM1
49.7VCAM1, ICAM1
59.7MMP9, SELE
69.5MMP9, NOS3
79.5MMP9, NOS3
8
Show member pathways
Angiogenesis36
9.5NOS3, MMP9
99.4VCAM1, ICAM1, SELE
109.4SELE, VCAM1, ICAM1
119.4VCAM1, ICAM1, SELE
129.3MMP9, PLAT
139.2NOS3, MMP9, TIMP1
149.2ICAM1, MMP9, VCAM1
159.0SERPINE1, PLAT
16
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades59
9.0NOS3, ICAM1, VCAM1, SELE
179.0VCAM1, NOS3, SELE, ICAM1
18
Show member pathways
Cytoskeleton remodeling FAK signaling59
Development Endothelin 1 EDNRA transactivation of EGFR59
8.9MMP9, NOS3, HTR2A, EDN1
198.9ICAM1, PLAT, MMP9
208.9SERPINE1, VCAM1, ICAM1
21
Show member pathways
thioredoxin pathway36
8.6PLAT, SERPINE1, ICAM1
228.5NOS3, EDN1, TIMP1, SERPINE1
238.5MMP9, SELE, ICAM1, EDN1, VCAM1
24
Show member pathways
8.3SERPINE1, ICAM1, VCAM1, MMP9
25
Show member pathways
Metalloproteases in connective tissue degradation
8.2MMP9, SERPINE1, PLAT, TIMP1
26
Show member pathways
8.0ICAM1, MMP9, VCAM1, SERPINE1, TIMP1
27
Show member pathways
8.0TIMP1, SERPINE1, NOS3, SELE, PLAT

Compounds for genes affiliated with Thromboangiitis Obliterans

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Compounds related to Thromboangiitis Obliterans according to GeneCards Suite gene sharing:

(show top 50)    (show all 213)
idCompoundScoreTop Affiliating Genes
1carvedilol44 50 28 1112.3VCAM1, EDN1, SELE, NOS3
2gliclazide44 50 1111.1PLAT, SELE, VCAM1, ICAM1
3iloprost60 28 44 1112.1PLAT, VCAM1, SELE, EDN1
4apocynin44 6010.0VCAM1, SELE, EDN1, ICAM1, NOS3
5polymyxin b448.9ICAM1, SERPINE1, SELE, VCAM1
6l-nmma448.8NOS3, EDN1, VCAM1, MMP9
7cytochalasin d44 609.8SELE, VCAM1, MMP9, ICAM1, TIMP1
8nebivolol44 119.8NOS3, SERPINE1, EDN1
9quinapril44 50 1110.7EDN1, SERPINE1, SELE, PLAT
10folate448.7NOS3, TIMP1, MMP9, VCAM1, SELE, APOH
11norepinephrine44 24 1110.7SELE, HTR2A, MMP9, VCAM1, TIMP1, EDN1
12hirudin448.6PLAT, SELE, SERPINE1, TIMP1
13herbimycin a44 609.6MMP9, SELE, TIMP1, ICAM1, VCAM1, EDN1
14ciglitazone44 289.5SERPINE1, MMP9, ICAM1, NOS3
15endotoxin448.5ICAM1, APOH, SERPINE1, SELE, VCAM1
16pravastatin44 50 28 24 1112.5NOS3, ICAM1, VCAM1, SELE, SERPINE1
17nifedipine44 28 50 1111.4TIMP1, MMP9, SELE, SERPINE1, EDN1
18histamine44 28 2410.4PLAT, VCAM1, EDN1, TIMP1, SELE, ICAM1
19losartan44 50 28 1111.4PLAT, VCAM1, SERPINE1, SELE, EDN1
20pge2448.3VCAM1, EDN1, TIMP1, SELE, MMP9, ICAM1
21lactate448.3TIMP1, APOH, ICAM1, SELE, VCAM1, MMP9
22sodium nitroprusside448.2VCAM1, PLAT, NOS3, SERPINE1, EDN1
23methotrexate50 44 1110.2TIMP1, APOH, MMP9, SELE, NOS3, SERPINE1
24cyclophosphamide44 50 1110.2APOH, NOS3, MMP9, VCAM1, SELE, SERPINE1
25rosiglitazone28 44 50 24 1112.2SELE, NOS3, MMP9, VCAM1, SERPINE1, TIMP1
26isoproterenol44 119.2SERPINE1, PLAT, SELE, EDN1, VCAM1
27homocysteine44 249.1APOH, VCAM1, PLAT, NOS3, SERPINE1, SELE
28aspirin44 50 28 2411.1SELE, NOS3, SERPINE1, TIMP1, APOH, PLAT
29fenofibrate44 50 1110.1SERPINE1, NOS3, SELE, VCAM1, MMP9, ICAM1
30phosphatidylinositol448.0MMP9, VCAM1, TIMP1, APOH, NOS3, EDN1
31nicotine44 28 50 1110.9SERPINE1, SELE, MMP9, ICAM1, PLAT
32troglitazone44 28 60 1110.8MMP9, VCAM1, SELE, PLAT, ICAM1, SERPINE1
33ly294002447.7MMP9, SELE, TIMP1, VCAM1, NOS3, ICAM1
34heparin44 28 24 1110.6APOH, SELE, PLAT, VCAM1, SERPINB1, TIMP1
35pd 98,059447.6VCAM1, SERPINE1, TIMP1, EDN1, ICAM1, NOS3
36nitric oxide44 24 119.6APOH, EDN1, ICAM1, TIMP1, SERPINE1, SELE
37fibrinogen447.6SELE, VCAM1, SERPINE1, ICAM1, PLAT, APOH
38aspartate447.5TIMP1, PLAT, VCAM1, SELE, SERPINE1, MMP9
39fluvastatin44 50 28 1110.5SELE, NOS3, VCAM1, MMP9, ICAM1, PLAT
40simvastatin44 50 60 28 24 1112.4SELE, PLAT, MMP9, ICAM1, VCAM1, SERPINE1
418-isoprostane447.4EDN1, VCAM1, NOS3, SELE, SERPINE1, MMP9
42cycloheximide447.4SERPINE1, SELE, PLAT, ICAM1, EDN1, TIMP1
43sb 20358044 608.4EDN1, SELE, VCAM1, MMP9, ICAM1, NOS3
44genistein44 28 60 1 24 1112.4MMP9, ICAM1, VCAM1, SELE, SERPINE1, TIMP1
45creatinine447.3SELE, EDN1, APOH, PLAT, MMP9, SERPINE1
46matrigel447.1SERPINE1, TIMP1, VCAM1, SELE, NOS3, MMP9
47vegf447.1TIMP1, APOH, SERPINE1, MMP9, SELE, NOS3
48actinomycin d447.1SELE, MMP9, EDN1, NOS3, TIMP1, ICAM1
49prostacyclin447.0ICAM1, VCAM1, SELE, SERPINE1, TIMP1, APOH
50atorvastatin44 50 28 24 1110.8TIMP1, SERPINE1, SELE, NOS3, PLAT, ICAM1

GO Terms for genes affiliated with Thromboangiitis Obliterans

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Cellular components related to Thromboangiitis Obliterans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1caveolaGO:00059019.4SELE, HTR2A, NOS3
2extracellular matrixGO:00310128.5PLAT, SERPINE1, APOH
3extracellular regionGO:00055767.8PLAT, MMP9, SERPINE1, TIMP1, EDN1
4extracellular spaceGO:00056156.2PLAT, EDN1, APOH, SERPINE1, SELE, SERPINB1

Biological processes related to Thromboangiitis Obliterans according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of smooth muscle cell apoptotic processGO:003439210.2EDN1, APOH
2artery smooth muscle contractionGO:001482410.1EDN1, HTR2A
3leukocyte tethering or rollingGO:005090110.1VCAM1, SELE
4negative regulation of potassium ion transportGO:004326710.1HTR2A, NOS3
5regulation of systemic arterial blood pressure by endothelinGO:000310010.0NOS3, EDN1
6membrane to membrane dockingGO:002261410.0VCAM1, ICAM1
7phosphatidylinositol 3-kinase signalingGO:001406510.0HTR2A, EDN1
8plasminogen activationGO:00316399.9APOH, PLAT
9negative regulation of calcium ion transportGO:00519269.9NOS3, ICAM1
10positive regulation of vasoconstrictionGO:00459079.9ICAM1, HTR2A
11agingGO:00075689.8TIMP1, HTR2A, VCAM1
12response to nicotineGO:00350949.8VCAM1, EDN1
13leukocyte cell-cell adhesionGO:00071599.8VCAM1, SELE, ICAM1
14heterophilic cell-cell adhesionGO:00071579.8SELE, VCAM1, ICAM1
15response to lipopolysaccharideGO:00324969.7EDN1, SELE, VCAM1
16negative regulation of fibrinolysisGO:00519189.7APOH, SERPINE1
17cellular response to glucose stimulusGO:00713339.7VCAM1, ICAM1
18cellular response to tumor necrosis factorGO:00713569.7EDN1, VCAM1, ICAM1
19response to amino acidGO:00432009.6ICAM1, EDN1
20positive regulation of blood coagulationGO:00301949.6APOH, SERPINE1
21positive regulation of nitric oxide biosynthetic processGO:00454299.5EDN1, ICAM1
22leukocyte migrationGO:00509009.5ICAM1, MMP9, SELE
23negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:019020429.4SERPINE1, NOS3
24negative regulation of blood coagulationGO:00301959.4SERPINE1, APOH, EDN1
25response to hypoxiaGO:00016669.4VCAM1, EDN1, PLAT
26cellular response to interleukin-1GO:00713479.3ICAM1, EDN1
27fibrinolysisGO:00427309.2PLAT, SERPINE1
28negative regulation of endopeptidase activityGO:00109519.1TIMP1, SERPINE1, SERPINB1
29extracellular matrix organizationGO:00301988.4MMP9, SERPINE1, VCAM1, ICAM1, TIMP1
30blood coagulationGO:00075968.4TIMP1, SERPINE1, SELE, PLAT, NOS3

Molecular functions related to Thromboangiitis Obliterans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.4NOS3, PLAT, ICAM1, MMP9, SELE, SERPINE1

Sources for Thromboangiitis Obliterans

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet