MCID: THR006
MIFTS: 63

Thromboangiitis Obliterans malady

Categories: Rare diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases, Blood diseases

Aliases & Classifications for Thromboangiitis Obliterans

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Sources:
32LifeMap Discovery®, 10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 47Novoseek, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Thromboangiitis Obliterans:

Name: Thromboangiitis Obliterans 32 10 45 12 51 36 65
Buerger Disease 45 47 51
Buerger's Disease 10 45
Inflammatory Occlusive Peripheral Vascular Disease 45
 
Occlusive Peripheral Vascular Disease 45
Thromboangiitis Obliterans Nos 10
Presenile Gangrene 10
Tao 45

Characteristics:

Orphanet epidemiological data:

51
thromboangiitis obliterans:
Prevalence: 1-5/10000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology10 DOID:12918
ICD1027 I73.1
ICD9CM29 443.1
MeSH36 D013919
NCIt42 C35070
Orphanet51 36258
ICD10 via Orphanet28 I73.1
UMLS65 C0040021

Summaries for Thromboangiitis Obliterans

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NIH Rare Diseases:45 Buerger disease is a disease of the arteries and veins in the arms and legs. the arteries and veins become inflamed which can lead to narrowed and blocked vessels. this reduces blood flow resulting in pain and eventually damage to affected tissues. buerger disease nearly always occurs in association with cigarette or other tobacco use. quitting all forms of tobacco is an essential part of treatment. last updated: 6/16/2015

MalaCards based summary: Thromboangiitis Obliterans, also known as buerger disease, is related to heart disease and thrombotic thrombocytopenic purpura, and has symptoms including chronic skin infection/ulcerations/ulcers/cancrum, arterial embolism/thrombosis and arterial pulse abolition. An important gene associated with Thromboangiitis Obliterans is NOS3 (Nitric Oxide Synthase 3), and among its related pathways are LDL Oxidation in Atherogenesis and Immune response_Role of integrins in NK cells cytotoxicity. The drugs isoxsuprine and isoxsuprine hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and endothelial, and related mouse phenotypes are digestive/alimentary and muscle.

Wikipedia:68 Thromboangiitis obliterans (also known as Buerger\'s disease, Buerger disease [English /bʌrɡər/;... more...

Related Diseases for Thromboangiitis Obliterans

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Diseases related to Thromboangiitis Obliterans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1heart disease30.1EDN1, HTR2A, NOS3
2thrombotic thrombocytopenic purpura29.9EDN1, HTR2A, NOS3
3chronic venous insufficiency29.9EDN1, NOS3, SELE
4progeria variant syndrome ruvalcaba type10.5EDN1, NOS3
5plasma cell neoplasm10.5ICAM1, VCAM1
6liver cirrhosis10.5ICAM1, VCAM1
7lethal congenital contractural syndrome 210.5EDN1, NOS3
8cerebritis10.5
9aortic dissection lentiginosis10.4EDN1, NOS3
10dyskinesia of esophagus10.4ICAM1, NOS3
11qualitative platelet defect10.4ICAM1, VCAM1
12acrodermatitis10.4EDN1, NOS3
13oral pharyngeal disorders10.4ICAM1, VCAM1
14dengue hemorrhagic fever10.4ICAM1, VCAM1
15islet cell tumor10.4EDN1, NOS3
16arteriosclerosis10.4
17colon carcinoma in situ10.4ICAM1, SELE
18suppurative uveitis10.4ICAM1, VCAM1
19solar retinopathy10.4ICAM1, SELE
20acute myeloblastic leukemia with maturation10.4EDN1, NOS3
21paraphilia disorder10.4HTR2A, NOS3
22ischemia10.4
23endotheliitis10.4
24diphyllobothriasis10.4ICAM1, SELE
25liver lymphoma10.3EDN1, NOS3
26polyneuropathy mental retardation acromicria premature menopause10.3ICAM1, VCAM1
27arteriosclerosis obliterans10.3
28intra-abdominal lymph node mast cell malignancy10.3ICAM1, SELE
29autosomal dominant cerebellar ataxia10.3ICAM1, SELE
30marasmus10.3EDN1, HTR2A
31bernard-soulier syndrome, type a210.3EDN1, NOS3
32parotitis10.3EDN1, HTR2A
33atherosclerosis10.3
34thrombophlebitis10.3
35gestational diabetes10.2EDN1, SELE
36vascular disease10.2
37pyrimidine metabolic disorder10.2ICAM1, NOS3, VCAM1
38mental retardation, x-linked 10110.2ICAM1, NOS3
39nephronophthisis familial adult spastic quadriparesis10.2EDN1, TIMP1
40citrullinemia, adult-onset type ii10.2ICAM1, NOS3, VCAM1
41rheumatic fever10.2EDN1, NOS3, VCAM1
42thyroiditis10.2
43preeclampsia/eclampsia 110.2EDN1, NOS3, VCAM1
44retinitis pigmentosa with or without situs inversus10.1EDN1, NOS3
45dentine erosion10.1MMP9, NOS3
46critical limb ischemia10.1
47artery disease10.1
48peripheral artery disease10.1
49limb ischemia10.1
50vasculitis10.1

Comorbidity relations with Thromboangiitis Obliterans via Phenotypic Disease Network (PDN):


Hypertension, EssentialPeripheral Vascular Disease
Ischemic Heart Disease

Graphical network of the top 20 diseases related to Thromboangiitis Obliterans:



Diseases related to thromboangiitis obliterans

Symptoms for Thromboangiitis Obliterans

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Symptoms:

 51 (show all 12)
  • chronic skin infection/ulcerations/ulcers/cancrum
  • arterial embolism/thrombosis
  • arterial pulse abolition
  • vascularitis/vasculitides/arteritis
  • gangrena/necrosis
  • sensitive trouble/deficit
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • acute ischemia of the lower limbs
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • articular/joint pain/arthralgia
  • hyperhidrosis/increased sweating
  • insomnia

UMLS symptoms related to Thromboangiitis Obliterans:


vasculitic rash

Drugs & Therapeutics for Thromboangiitis Obliterans

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Drugs for Thromboangiitis Obliterans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Pharmaceutical SolutionsPhase 1, Phase 27004
2AnestheticsPhase 1, Phase 27385
3Vasodilator AgentsPhase 22926
4AnticoagulantsPhase 21760
5
Citric AcidnutraceuticalPhase 1, Phase 2100177-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
6CitrateNutraceuticalPhase 1, Phase 21001
7
Bosentanapproved, investigational100147536-97-8104865
Synonyms:
-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
AC-148
AC1L2XN2
Actelion
Bosentan
Bosentan (INN)
Bosentan [USAN:INN:BAN]
Bosentan hydrate
Bosentanum
C27H29N5O6S
CHEBI:51450
CHEMBL957
CID104865
D07538
 
DB00559
EN002863
HMS2090N14
I06-1873
KS-5062
L001086
LS-31532
MolPort-003-845-300
NCGC00167440-01
P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
UNII-XUL93R30K2
bosentanum
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
p-tert-Butyl-N-[6-(2-hydroxyethoxy)
8Endothelin Receptor Antagonists189
9Antihypertensive Agents3618

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Buerger's DiseaseCompletedNCT01302015Phase 1, Phase 2
2Autologous Endothelial Progenitor Cells (EPCs) From Peripheral Blood in the Treatment of Critical Limb IschemiaCompletedNCT01595776Phase 1, Phase 2
3A Clinical Trial to Study the Efficacy and Safety of Different Doses of Bone Marrow Derived Mesenchymal Stem Cells in Patients With Critical Limb Ischemia Due to Buergers DiseaseRecruitingNCT01484574Phase 2
4TACT-NAGOYA: Therapeutic Angiogenesis Using Cell TransplantationRecruitingNCT00145262Phase 2
5Safety and Efficacy Study of Autologous BM-MNC Processed by Two Methods for Treating Patients With Chronic Limb IschemiaNot yet recruitingNCT01446055Phase 1, Phase 2
6Study to Assess the Efficacy and Safety of CLBS12 in Patients With Critical Limb Ischemia (CLI)Not yet recruitingNCT02501018Phase 2
7Treatment of Thromboangiitis Obliterans (Buerguer's Disease) With BosentanCompletedNCT01447550
8Contrast Enhanced Ultrasound and MuscleCompletedNCT02128750
9ADDICTAO: Psychological and Addictive Profile of Patients With Buerger's DiseaseRecruitingNCT01064206
10Purified CD34+ Cells Versus Peripheral Blood Mononuclear Cells in Treatment of Critical Limb IschemiaRecruitingNCT02089828
11Evaluation of a Combined Parent-student Programme for Smoking Prevention in Berlin SchoolsRecruitingNCT01306552

Search NIH Clinical Center for Thromboangiitis Obliterans

Inferred drug relations via UMLS65/NDF-RT43:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Thromboangiitis Obliterans cell therapies at LifeMap Discovery.

Genetic Tests for Thromboangiitis Obliterans

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Anatomical Context for Thromboangiitis Obliterans

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MalaCards organs/tissues related to Thromboangiitis Obliterans:

33
Bone, Liver, Endothelial, Lung, Skin, Colon, Heart

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Thromboangiitis Obliterans:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Thromboangiitis Obliterans or affiliated genes

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MGI Mouse Phenotypes related to Thromboangiitis Obliterans:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4EDN1, HTR2A, ICAM1, MMP9, NOS3
2MP:00053698.3EDN1, HTR2A, ICAM1, MMP9, NOS3
3MP:00053798.2EDN1, HTR2A, ICAM1, NOS3, TIMP1
4MP:00053907.7EDN1, HTR2A, MMP9, NOS3, TIMP1
5MP:00053877.4ICAM1, MMP9, NOS3, SELE, TIMP1, VCAM1
6MP:00053767.2EDN1, ICAM1, MMP9, NOS3, SELE, TIMP1
7MP:00053977.2ICAM1, MMP9, NOS3, SELE, TIMP1, VCAM1
8MP:00107687.2EDN1, ICAM1, MMP9, NOS3, SELE, TIMP1
9MP:00053787.1EDN1, ICAM1, MMP9, NOS3, SELE, TIMP1
10MP:00053857.0EDN1, ICAM1, MMP9, NOS3, SELE, TIMP1

Publications for Thromboangiitis Obliterans

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Articles related to Thromboangiitis Obliterans:

(show top 50)    (show all 325)
idTitleAuthorsYear
1
Thromboangiitis obliterans (Buerger's disease). (27144003)
2016
2
Autologous peripheral blood stem cell transplantation to treat thromboangiitis obliterans: preliminary results. (26914127)
2016
3
The Pathogenesis and Diagnosis of Thromboangiitis obliterans: Is It Still a Mystery? (26771983)
2015
4
Integrated treatment for lower-limb stage II thromboangiitis obliterans by interventional therapy and oral administration of Chinese medicine: a randomized controlled clinical trial. (25842727)
2015
5
Buerger Disease (Thromboangiitis Obliterans). (25770636)
2014
6
The value of FDG-PET in the diagnosis of thromboangiitis obliterans-a case series. (24794493)
2014
7
Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost. (25005765)
2014
8
Imbalanced matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 activities in patients with thromboangiitis obliterans. (22402936)
2012
9
Buerger's disease (Thromboangiitis obliterans): a diagnostic challenge. (22679237)
2011
10
Buerger's Disease (Thromboangiitis Obliterans)- Management by Ilizarov's Technique of Horizontal Distraction. A Retrospective Study of 60 Cases. (22211037)
2011
11
Effectiveness of bosentan in the treatment of ischemic lesions in a case of thromboangiitis obliterans (Buerger disease): a case report. (21810389)
2011
12
Protective effect of Shenfu injection on thromboangiitis obliterans model rats. (21982791)
2011
13
Color doppler flows of corkscrew collaterals in Thromboangiitis obliterans (Buerger's disease) using color duplex ultrasonography. (21679855)
2011
14
Classification of corkscrew collaterals in thromboangiitis obliterans (Buerger's disease): relationship between corkscrew type and prevalence of ischemic ulcers. (20534945)
2010
15
Thromboangiitis obliterans and endothelial function. (20584171)
2010
16
Treatment of Buerger disease (thromboangiitis obliterans) with bosentan: a case report. (21686681)
2009
17
A prospective, case-control study of tobacco dependence in thromboangiitis obliterans (Buerger's Disease). (16444459)
2006
18
One of the most frequent vascular diseases in northeastern of Turkey: Thromboangiitis obliterans or Buerger's disease (experience with 344 cases). (16580754)
2006
19
Inflammatory joint disease and severe ischemia of the extremities revealing thromboangiitis obliterans in a female. (15681252)
2005
20
Thromboangiitis obliterans associated with peripheral blood and eosinophilic cellulitis-like skin lesions. (15985040)
2005
21
Distribution of arterial involvement in thromboangiitis obliterans (Buerger's disease): results of a study conducted by the Intractable Vasculitis Syndromes Research Group in Japan. (10930225)
2000
22
Implantable spinal cord stimulator to treat the ischemic manifestations of thromboangiitis obliterans (Buerger's disease). (10231644)
1999
23
Study of anti-neutrophil cytoplasmic antibodies in patients with thromboangiitis obliterans (Buerger's disease). (9822265)
1998
24
Is the capillary microscopic determination of the visible capillary length a diagnostic criterion in thromboangiitis obliterans? (9612111)
1998
25
Inpatient treatment of severe nicotine dependence in a patient with thromboangiitis obliterans (Buerger's disease). (9621859)
1998
26
Thromboangiitis obliterans (Buerger's disease) in visceral vessels confirmed by angiographic and histological findings. (9854560)
1998
27
Thromboangiitis obliterans (Buerger's disease). (9189999)
1997
28
Pharmacokinetics and tolerability of oral iloprost in thromboangiitis obliterans patients. (9349930)
1997
29
Thromboangiitis obliterans (Buerger's disease) (9119522)
1996
30
Case of thromboangiitis obliterans (Buerger's disease) of the upper lip. (7573750)
1995
31
Impotence as a cardinal sign in the thromboangiitis obliterans diagnosis. (8608695)
1995
32
Cerebral thromboangiitis obliterans: clinical and MRI findings in a case. (7671993)
1995
33
Thromboangiitis obliterans. (7518238)
1994
34
Buerger's disease (thromboangiitis obliterans). (2189162)
1990
35
Serum zinc and copper in patients with atherosclerosis and thromboangiitis obliterans. (2484753)
1989
36
CAT scan and immunohistochemical findings in a case of cerebral thromboangiitis obliterans (Buerger's disease). (6714279)
1984
37
Cellular sensitivity to collagen in thromboangiitis obliterans. (6835334)
1983
38
Buerger's disease (thromboangiitis obliterans): an analysis of the arteriograms of 119 cases. (7067357)
1982
39
Autoantibodies in thromboangiitis obliterans (Buerger's disease). (6751163)
1982
40
Factors influenced on prognosis of reconstructive surgery for peripheral arterial occlusion: comparative study between arteriosclerosis obliterans and thromboangiitis obliterans. (599159)
1977
41
Traditional chinese medicine in the treatment of thromboangiitis obliterans. Report of 136 cases. (5678364)
1968
42
Coexistence of thromboangiitis obliterans and arteriosclerosis: relationship to smoking. (5914684)
1966
43
Thromboangiitis obliterans and arteriosclerosis obliterans. (5833515)
1965
44
THROMBOANGIITIS OBLITERANS AND ARTERIOSCLEROSIS OBLITERANS. CLINICAL AND PROGNOSTIC DIFFERENCES. (14065946)
1963
45
Cogan's syndrome and systemic vascular disease. Analysis of pathologic features with reference to its relationship to thromboangiitis obliterans (Buerger). (13893233)
1961
46
Thromboangiitis obliterans: a 30-year study. (13502019)
1958
47
Thromboangiitis obliterans in two brothers. (14952874)
1952
48
A follow-up study of patient with thromboangiitis obliterans (Buerger's disease). (15395864)
1949
49
Cerebral thromboangiitis obliterans. (20289123)
1947
50
Treatment of thromboangiitis obliterans. (21006071)
1945

Variations for Thromboangiitis Obliterans

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Expression for genes affiliated with Thromboangiitis Obliterans

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Search GEO for disease gene expression data for Thromboangiitis Obliterans.

Pathways for genes affiliated with Thromboangiitis Obliterans

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Pathways related to Thromboangiitis Obliterans according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathwaysScoreTop Affiliating Genes
19.7ICAM1, VCAM1
29.7ICAM1, VCAM1
39.7ICAM1, VCAM1
49.7EDN1, NOS3
59.6MMP9, NOS3
69.6MMP9, NOS3
79.6MMP9, NOS3
89.5ICAM1, MMP9
99.4MMP9, SELE
10
Show member pathways
9.3TIMP1, VCAM1
11
Show member pathways
9.2EDN1, TIMP1
129.2ICAM1, SELE, VCAM1
139.2ICAM1, SELE, VCAM1
149.2ICAM1, SELE, VCAM1
159.1MMP9, TIMP1
168.9EDN1, NOS3, TIMP1
178.9EDN1, NOS3, TIMP1
188.8ICAM1, NOS3, SELE, VCAM1
19
Show member pathways
8.8ICAM1, NOS3, SELE, VCAM1
20
Show member pathways
8.8ICAM1, MMP9, NOS3, VCAM1
21
Show member pathways
8.5EDN1, HTR2A, MMP9, NOS3
22
Show member pathways
8.4NOS3, SELE, TIMP1, VCAM1
238.4EDN1, ICAM1, NOS3, SELE, VCAM1
24
Show member pathways
8.3ICAM1, MMP9, TIMP1, VCAM1
258.2EDN1, ICAM1, MMP9, SELE, VCAM1

GO Terms for genes affiliated with Thromboangiitis Obliterans

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Biological processes related to Thromboangiitis Obliterans according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by endothelinGO:000310010.3EDN1, NOS3
2leukocyte cell-cell adhesionGO:000715910.2ICAM1, VCAM1
3positive regulation of nitric oxide biosynthetic processGO:004542910.2EDN1, ICAM1
4regulation of blood pressureGO:000821710.1EDN1, NOS3
5interferon-gamma-mediated signaling pathwayGO:006033310.0ICAM1, VCAM1
6response to amino acidGO:004320010.0EDN1, ICAM1
7heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:000715710.0ICAM1, SELE
8artery smooth muscle contractionGO:001482410.0EDN1, HTR2A
9negative regulation of potassium ion transportGO:00432679.9HTR2A, NOS3
10positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.8HTR2A, ICAM1
11viral entry into host cellGO:00467189.7HTR2A, ICAM1
12sensory perception of painGO:00192339.5EDN1, HTR2A
13cartilage developmentGO:00512169.5EDN1, TIMP1
14cell adhesionGO:00071559.3ICAM1, SELE, VCAM1
15response to lipopolysaccharideGO:00324969.1EDN1, ICAM1, SELE
16extracellular matrix organizationGO:00301988.9ICAM1, TIMP1, VCAM1

Sources for Thromboangiitis Obliterans

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet