MCID: THR006
MIFTS: 59

Thromboangiitis Obliterans malady

Categories: Rare diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases, Blood diseases

Aliases & Classifications for Thromboangiitis Obliterans

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Sources:
32LifeMap Discovery®, 10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 47Novoseek, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Thromboangiitis Obliterans:

Name: Thromboangiitis Obliterans 32 10 45 12 51 36 65
Buerger Disease 45 47 51
Buerger's Disease 10 45
Inflammatory Occlusive Peripheral Vascular Disease 45
 
Occlusive Peripheral Vascular Disease 45
Thromboangiitis Obliterans Nos 10
Presenile Gangrene 10
Tao 45

Characteristics:

Orphanet epidemiological data:

51
thromboangiitis obliterans:
Prevalence: 1-5/10000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology10 DOID:12918
ICD1027 I73.1
ICD9CM29 443.1
MeSH36 D013919
NCIt42 C35070
Orphanet51 36258
ICD10 via Orphanet28 I73.1
UMLS65 C0040021

Summaries for Thromboangiitis Obliterans

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NIH Rare Diseases:45 Buerger disease is a disease of the arteries and veins in the arms and legs. the arteries and veins become inflamed which can lead to narrowed and blocked vessels. this reduces blood flow resulting in pain and eventually damage to affected tissues. buerger disease nearly always occurs in association with cigarette or other tobacco use. quitting all forms of tobacco is an essential part of treatment. last updated: 6/16/2015

MalaCards based summary: Thromboangiitis Obliterans, also known as buerger disease, is related to parotitis and gestational diabetes, and has symptoms including chronic skin infection/ulcerations/ulcers/cancrum, arterial embolism/thrombosis and arterial pulse abolition. An important gene associated with Thromboangiitis Obliterans is NOS3 (Nitric Oxide Synthase 3), and among its related pathways are Immune response_MIF-mediated glucocorticoid regulation and LDL Oxidation in Atherogenesis. The drugs isoxsuprine and isoxsuprine hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and heart, and related mouse phenotypes are digestive/alimentary and muscle.

Wikipedia:68 Thromboangiitis obliterans (also known as Buerger\'s disease, Buerger disease [English /bʌrɡər/;... more...

Related Diseases for Thromboangiitis Obliterans

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Diseases related to Thromboangiitis Obliterans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 325)
idRelated DiseaseScoreTop Affiliating Genes
1parotitis30.4EDN1, HTR2A
2gestational diabetes30.3EDN1, SELE
3corneal dystrophy30.1MMP9, TIMP1
4coronary artery disease30.0EDN1, NOS3, SELE
5obstructive sleep apnea29.7EDN1, HTR2A, ICAM1, NOS3
6pulmonary sarcoidosis29.5EDN1, MMP9, TIMP1
7myocardial infarction29.5NOS3, SELE, TIMP1, VCAM1
8lung cancer10.5
9breast cancer10.4
10hepatitis10.4
11lymphoma10.4
12arthritis10.4
13leukemia10.4
14adenocarcinoma10.4
15endotheliitis10.4
16progeria variant syndrome ruvalcaba type10.3EDN1, NOS3
17plasma cell neoplasm10.3ICAM1, VCAM1
18liver cirrhosis10.3ICAM1, VCAM1
19lethal congenital contractural syndrome 210.3EDN1, NOS3
20rheumatoid arthritis10.3
21attention deficit-hyperactivity disorder10.3
22cystic fibrosis10.3
23cataract10.3
24prostatitis10.3
25tuberculosis10.3
26pancreatitis10.3
27aortic dissection lentiginosis10.3EDN1, NOS3
28dyskinesia of esophagus10.3ICAM1, NOS3
29qualitative platelet defect10.3ICAM1, VCAM1
30acrodermatitis10.3EDN1, NOS3
31oral pharyngeal disorders10.3ICAM1, VCAM1
32dengue hemorrhagic fever10.3ICAM1, VCAM1
33islet cell tumor10.3EDN1, NOS3
34colon carcinoma in situ10.3ICAM1, SELE
35suppurative uveitis10.2ICAM1, VCAM1
36solar retinopathy10.2ICAM1, SELE
37acute myeloblastic leukemia with maturation10.2EDN1, NOS3
38paraphilia disorder10.2HTR2A, NOS3
39diphyllobothriasis10.2ICAM1, SELE
40liver lymphoma10.2EDN1, NOS3
41polyneuropathy mental retardation acromicria premature menopause10.2ICAM1, VCAM1
42cystinuria10.2
43hepatocellular carcinoma10.2
44obesity10.2
45renal cell carcinoma10.2
46multiple myeloma10.2
47alopecia10.2
48gastric cancer10.2
49thalassemia10.2
50myeloma10.2

Graphical network of the top 20 diseases related to Thromboangiitis Obliterans:



Diseases related to thromboangiitis obliterans

Symptoms for Thromboangiitis Obliterans

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Symptoms:

 51 (show all 12)
  • chronic skin infection/ulcerations/ulcers/cancrum
  • arterial embolism/thrombosis
  • arterial pulse abolition
  • vascularitis/vasculitides/arteritis
  • gangrena/necrosis
  • sensitive trouble/deficit
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • acute ischemia of the lower limbs
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • articular/joint pain/arthralgia
  • hyperhidrosis/increased sweating
  • insomnia

Drugs & Therapeutics for Thromboangiitis Obliterans

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Drugs for Thromboangiitis Obliterans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Pharmaceutical SolutionsPhase 1, Phase 27004
2AnestheticsPhase 1, Phase 27385
3Vasodilator AgentsPhase 22926
4AnticoagulantsPhase 21760
5
Citric AcidnutraceuticalPhase 1, Phase 2100177-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
6CitrateNutraceuticalPhase 1, Phase 21001
7
Bosentanapproved, investigational100147536-97-8104865
Synonyms:
-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
AC-148
AC1L2XN2
Actelion
Bosentan
Bosentan (INN)
Bosentan [USAN:INN:BAN]
Bosentan hydrate
Bosentanum
C27H29N5O6S
CHEBI:51450
CHEMBL957
CID104865
D07538
 
DB00559
EN002863
HMS2090N14
I06-1873
KS-5062
L001086
LS-31532
MolPort-003-845-300
NCGC00167440-01
P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
UNII-XUL93R30K2
bosentanum
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
p-tert-Butyl-N-[6-(2-hydroxyethoxy)
8Endothelin Receptor Antagonists189
9Antihypertensive Agents3618

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Buerger's DiseaseCompletedNCT01302015Phase 1, Phase 2
2Autologous Endothelial Progenitor Cells (EPCs) From Peripheral Blood in the Treatment of Critical Limb IschemiaCompletedNCT01595776Phase 1, Phase 2
3A Clinical Trial to Study the Efficacy and Safety of Different Doses of Bone Marrow Derived Mesenchymal Stem Cells in Patients With Critical Limb Ischemia Due to Buergers DiseaseRecruitingNCT01484574Phase 2
4TACT-NAGOYA: Therapeutic Angiogenesis Using Cell TransplantationRecruitingNCT00145262Phase 2
5Safety and Efficacy Study of Autologous BM-MNC Processed by Two Methods for Treating Patients With Chronic Limb IschemiaNot yet recruitingNCT01446055Phase 1, Phase 2
6Study to Assess the Efficacy and Safety of CLBS12 in Patients With Critical Limb Ischemia (CLI)Not yet recruitingNCT02501018Phase 2
7Treatment of Thromboangiitis Obliterans (Buerguer's Disease) With BosentanCompletedNCT01447550
8Contrast Enhanced Ultrasound and MuscleCompletedNCT02128750
9ADDICTAO: Psychological and Addictive Profile of Patients With Buerger's DiseaseRecruitingNCT01064206
10Purified CD34+ Cells Versus Peripheral Blood Mononuclear Cells in Treatment of Critical Limb IschemiaRecruitingNCT02089828
11Evaluation of a Combined Parent-student Programme for Smoking Prevention in Berlin SchoolsRecruitingNCT01306552

Search NIH Clinical Center for Thromboangiitis Obliterans

Inferred drug relations via UMLS65/NDF-RT43:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Thromboangiitis Obliterans cell therapies at LifeMap Discovery.

Genetic Tests for Thromboangiitis Obliterans

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Anatomical Context for Thromboangiitis Obliterans

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MalaCards organs/tissues related to Thromboangiitis Obliterans:

33
Bone, Endothelial, Heart, Lung, Skin, Brain, Liver

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Thromboangiitis Obliterans:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Thromboangiitis Obliterans or affiliated genes

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MGI Mouse Phenotypes related to Thromboangiitis Obliterans:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4EDN1, HTR2A, ICAM1, MMP9, NOS3
2MP:00053698.3EDN1, HTR2A, ICAM1, MMP9, NOS3
3MP:00053798.2EDN1, HTR2A, ICAM1, NOS3, TIMP1
4MP:00053907.7EDN1, HTR2A, MMP9, NOS3, TIMP1
5MP:00053877.4ICAM1, MMP9, NOS3, SELE, TIMP1, VCAM1
6MP:00053767.2EDN1, ICAM1, MMP9, NOS3, SELE, TIMP1
7MP:00053977.2ICAM1, MMP9, NOS3, SELE, TIMP1, VCAM1
8MP:00107687.2EDN1, ICAM1, MMP9, NOS3, SELE, TIMP1
9MP:00053787.1EDN1, ICAM1, MMP9, NOS3, SELE, TIMP1
10MP:00053857.0EDN1, ICAM1, MMP9, NOS3, SELE, TIMP1

Publications for Thromboangiitis Obliterans

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Articles related to Thromboangiitis Obliterans:

(show top 50)    (show all 319)
idTitleAuthorsYear
1
Prevalence of Insomnia and Associated Factors in Outpatients with Generalized Anxiety Disorder Treated in Psychiatric Clinics. (27167699)
2016
2
The functional activity of hypothalamic signaling systems in rats with neonatal diabetes mellitus treated with metformin. (27193707)
2016
3
Fate of Distal False Aneurysms Complicating Internal Carotid Artery Dissection: A Systematic Review. (27117247)
2016
4
Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. (25470342)
2015
5
The effect of phacoemulsification on intraocular pressure in medically controlled open-angle glaucoma patients. (24182743)
2014
6
Bone fracture healing: Cell therapy in delayed unions and nonunions. (25093266)
2014
7
Evaluation of inflammatory mediators in the deciduas of pregnant women with pre-eclampsia/eclampsia. (25388357)
2014
8
Transforming growth factor-I^-activated kinase 1 regulates angiogenesis via AMP-activated protein kinase-I+1 and redox balance in endothelial cells. (24072697)
2013
9
Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. (23221128)
2013
10
Identification of a series of 1,3,4-trisubstituted pyrazoles as novel hepatitis C virus entry inhibitors. (24125883)
2013
11
A reduced zinc diet or zinc transporter 3 knockout attenuate light induced zinc accumulation and retinal degeneration. (23274584)
2013
12
Cytoplasmic p27Kip1 counteracts the pro-apoptotic function of the open conformation of PTEN by retention and destabilization of PTEN outside of the nucleus. (22036806)
2012
13
Excisional biopsy for management of lateral tongue leukoplakia. (22077669)
2012
14
Rodent animal models for surrogate analysis of cell therapy in acute liver failure. (22485094)
2012
15
Peripheral facial paralysis and bilateral carotid pseudoaneurysms of petrous localization: a case report. (23984216)
2011
16
Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence. (20214800)
2010
17
Calcific tendinitis: a pictorial review. (19931132)
2009
18
Real-time fluorescent quantitative polymerase chain reaction study of polo-like kinase-1 in pterygia. (20146883)
2009
19
Homocysteine, lipid indices and antioxidants in patients with ischaemic heart disease from Maharashtra, India. (19421689)
2009
20
Activity-guided antithrombin III therapy in severe surgical sepsis: efficacy and safety according to a retrospective data analysis. (18520701)
2008
21
The role of COX-2 in heart pathology. (18220723)
2008
22
Recurrent gynandroblastoma of ovary-A case report: a molecular and immunohistochemical analysis. (17197894)
2007
23
Influence of secondary infection on amputation in chronic critical limb ischemia. (17227717)
2007
24
Virtual cystoscopy: reality in imaging of bladder tuberculosis. (16534162)
2006
25
Rhabdomyolysis of the left upper leg after cocaine abuse. (16883771)
2006
26
Correlation between APOA gene polymorphism and intracranial aneurysm]. (15782489)
2005
27
Early cerebral sinovenous thrombosis in a child with acute lymphoblastic leukemia carrying the prothrombin G20210A variant: a case report and review of the literature. (15650545)
2005
28
Study of survival of motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) gene deletions in SMA patients. (15772743)
2005
29
Diffusely increased bone scintigraphic uptake in patellofemoral pain syndrome. (15728696)
2005
30
Does leptin link sleep loss and breathing disturbances with major public diseases? (15181973)
2004
31
Metabolic profile of nicotine in subjects whose CYP2A6 gene is deleted. (15265511)
2004
32
Fibroblast growth factor-2 over-rides insulin-like growth factor-I induced proliferation and cell survival in human neuroblastoma cells. (15095284)
2004
33
The calcium-sensing receptor in human disease. (12700051)
2003
34
Molecular characterization of rabbit phospholipid transfer protein: choroid plexus and ependyma synthesize high levels of phospholipid transfer protein. (11907147)
2002
35
Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7. (11580893)
2001
36
Epiphora caused by conjunctivochalasis: treatment with transplantation of preserved human amniotic membrane. (11473163)
2001
37
Cytotoxic effects of dynorphins through nonopioid intracellular mechanisms. (11525639)
2001
38
alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles. (10536043)
1999
39
A solid-phase glycosyltransferase assay for high-throughput screening in drug discovery research. (10972139)
1999
40
The expression and role of insulin-like growth factor II in malignant hemangiopericytomas. (10682323)
1999
41
Malignancy arising in seborrheic keratosis: a report of two cases. (9208082)
1997
42
Differences in dexamethasone-sensitivity between lymphocytes from patients with Alzheimer's disease and patients with multi-infarct dementia. (8811935)
1996
43
Amplification and expression of EMS-1 (cortactin) in head and neck squamous cell carcinoma cell lines. (8552396)
1996
44
Cost-effectiveness of screening and early treatment of nephropathy in patients with insulin-dependent diabetes mellitus. (1457753)
1992
45
Effect of Candida albicans plus histamine on prostaglandin E2 production by peripheral blood mononuclear cells from healthy women and women with recurrent candidal vaginitis. (1906913)
1991
46
Human urate oxidase gene: cloning and partial sequence analysis reveal a stop codon within the fifth exon. (2403354)
1990
47
Intramuscular hemangioma of the infratemporal fossa. (2123325)
1990
48
Human liver GTP cyclohydrolase I: purification and some properties. (2500984)
1989
49
Familial oligodendroglioma. Case report. (6707755)
1984
50
Infectivity of a multiploid-forming mutant of western equine encephalitis virus. (978836)
1976

Variations for Thromboangiitis Obliterans

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Expression for genes affiliated with Thromboangiitis Obliterans

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Search GEO for disease gene expression data for Thromboangiitis Obliterans.

Pathways for genes affiliated with Thromboangiitis Obliterans

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Pathways related to Thromboangiitis Obliterans according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
19.7ICAM1, VCAM1
29.7ICAM1, VCAM1
39.7ICAM1, VCAM1
49.7EDN1, NOS3
59.6MMP9, NOS3
69.6MMP9, NOS3
79.6MMP9, NOS3
89.5ICAM1, MMP9
99.4MMP9, SELE
10
Show member pathways
9.3TIMP1, VCAM1
11
Show member pathways
9.2EDN1, TIMP1
129.2ICAM1, SELE, VCAM1
139.2ICAM1, SELE, VCAM1
149.2ICAM1, SELE, VCAM1
159.1MMP9, TIMP1
168.9EDN1, NOS3, TIMP1
178.9EDN1, NOS3, TIMP1
188.8ICAM1, NOS3, SELE, VCAM1
19
Show member pathways
8.8ICAM1, NOS3, SELE, VCAM1
20
Show member pathways
8.8ICAM1, MMP9, NOS3, VCAM1
21
Show member pathways
8.5EDN1, HTR2A, MMP9, NOS3
228.4EDN1, ICAM1, NOS3, SELE, VCAM1
23
Show member pathways
8.3ICAM1, MMP9, TIMP1, VCAM1
248.2EDN1, ICAM1, MMP9, SELE, VCAM1

GO Terms for genes affiliated with Thromboangiitis Obliterans

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Biological processes related to Thromboangiitis Obliterans according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by endothelinGO:000310010.3EDN1, NOS3
2leukocyte cell-cell adhesionGO:000715910.2ICAM1, VCAM1
3positive regulation of nitric oxide biosynthetic processGO:004542910.2EDN1, ICAM1
4regulation of blood pressureGO:000821710.1EDN1, NOS3
5interferon-gamma-mediated signaling pathwayGO:006033310.0ICAM1, VCAM1
6response to amino acidGO:004320010.0EDN1, ICAM1
7heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:000715710.0ICAM1, SELE
8artery smooth muscle contractionGO:001482410.0EDN1, HTR2A
9negative regulation of potassium ion transportGO:00432679.9HTR2A, NOS3
10positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.8HTR2A, ICAM1
11viral entry into host cellGO:00467189.7HTR2A, ICAM1
12sensory perception of painGO:00192339.5EDN1, HTR2A
13cartilage developmentGO:00512169.5EDN1, TIMP1
14cell adhesionGO:00071559.3ICAM1, SELE, VCAM1
15response to lipopolysaccharideGO:00324969.1EDN1, ICAM1, SELE
16extracellular matrix organizationGO:00301988.9ICAM1, TIMP1, VCAM1

Sources for Thromboangiitis Obliterans

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet