TAO
MCID: THR006
MIFTS: 75

Thromboangiitis Obliterans (TAO) malady

Cardiovascular diseases, Nephrological diseases, Bone diseases, Blood diseases categories

Summaries for Thromboangiitis Obliterans

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Sources:
42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Buerger disease is a disease that causes obstruction of the blood vessels of the hands and feet. it is caused by vasculitis, which is an inflammation of blood vessels. the blood vessels of the hands and feet are especially affected, becoming constricted or totally blocked. this reduces blood flow to the tissues of hands and feet, resulting in pain and eventually damage. last updated: 11/19/2009

MalaCards: Thromboangiitis Obliterans, also known as buerger disease, is related to arteriosclerosis obliterans and arteriosclerosis, and has symptoms including insomnia, hyperhidrosis/increased sweating and articular/joint pain/arthralgia. An important gene associated with Thromboangiitis Obliterans is SELE (selectin E), and among its related pathways are Adhesion and LDL Oxidation in Atherogenesis. The drugs isoxsuprine and tolazoline and the compounds norepinephrine and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and endothelial, and related mouse phenotypes are respiratory system and cardiovascular system.

Wikipedia:63 Thromboangiitis obliterans (also known as Buerger\'s disease, Buerger disease [English /bʌrɡər/;... more...

Description from OMIM:46 211480

Aliases & Classifications for Thromboangiitis Obliterans

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 48Orphanet, 46OMIM, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

48
thromboangiitis obliterans:
Prevalence: 1-5/10000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

thromboangiitis obliterans 8 42 48 30 60
buerger disease 42 44 48 46
buerger's disease 8 42
inflammatory occlusive peripheral vascular disease 42
occlusive peripheral vascular disease 42
thromboangiitis obliterans nos 8
presenile gangrene 8
tao 42


External Ids:

Disease Ontology8 DOID:12918
MeSH34 D013919
OMIM46 211480
NCIt39 C35070
ICD9CM27 443.1
SNOMED-CT via Orphanet57 52403007
ICD10 via Orphanet26 I73.1
ICD1025 I73.1

Related Diseases for Thromboangiitis Obliterans

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17GeneCards, 18GeneDecks
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Diseases related to Thromboangiitis Obliterans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis obliterans30.9ICAM1, VCAM1
2arteriosclerosis30.9SERPINE1, VCAM1, NOS3, EDN1, ICAM1
3ischemia30.8SELE, NOS3, PLAT, EDN1, ICAM1
4vascular disease30.7SERPINE1, SELE, VCAM1, NOS3, PLAT, MMP9
5thrombophlebitis30.7APOH
6atherosclerosis30.7SERPINE1, SELE, VCAM1, NOS3, PLAT, MMP9
7vasculitis30.4SERPINB1, SELE, VCAM1, APOH, ICAM1
8coronary artery disease30.4ICAM1, EDN1, MMP9, PLAT, NOS3, VCAM1
9dilated cardiomyopathy30.2EDN1
10carotid artery thrombosis30.2SERPINE1
11peripheral vascular disease30.2VCAM1, SELE, SERPINE1
12impotence30.2EDN1, NOS3
13pulmonary embolism30.2APOH, PLAT
14ischemic heart disease30.2EDN1, PLAT, NOS3, SERPINE1
15thrombophilia30.2APOH, PLAT, SELE, SERPINE1
16arthritis30.2TIMP1, ICAM1, MMP9, SELE
17hyperhomocysteinemia30.2SERPINE1, SELE, VCAM1, NOS3, PLAT, APOH
18obesity29.9SERPINE1, SELE, NOS3, HTR2A
19diabetes mellitus29.9ICAM1, EDN1, MMP9, PLAT, NOS3, VCAM1
20cerebritis10.7
21intestinal disease10.4
22critical limb ischemia10.3
23spinal cord disease10.3
24splenic disease10.3
25thyroiditis10.3
26aortic disease10.2
27paronychia10.2
28cellulitis10.2
29nicotine dependence10.2
30blood platelet disease10.2
31colonic disease10.2
32diarrhea10.2
33eosinophilia10.2
34phlebitis10.2
35vein disease10.2
36venous insufficiency10.2
37compartment syndrome10.0
38intermittent claudication10.0HTR2A
39dementia10.0HTR2A
40cystic fibrosis10.0HTR2A
41coronary stenosis10.0HTR2A
42glaucoma10.0EDN1
43alpha 1-antitrypsin deficiency10.0SERPINB1
44inflammatory bowel disease10.0ICAM1
45sarcoidosis10.0ICAM1
46intracranial aneurysm10.0NOS3
47systemic scleroderma10.0EDN1
48pancreatitis10.0ICAM1
49primary pulmonary hypertension10.0EDN1
50malaria10.0ICAM1

Graphical network of the top 20 diseases related to Thromboangiitis Obliterans:



Diseases related to thromboangiitis obliterans

Clinical Features for Thromboangiitis Obliterans

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Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

211480

Clinical synopsis from OMIM:

211480

Symptoms:

48 (show all 12)
  • insomnia
  • hyperhidrosis/increased sweating
  • articular/joint pain/arthralgia
  • arterial embolism/thrombosis
  • arterial pulse abolition
  • vascularitis/vasculitides/arteritis
  • gangrena/necrosis
  • sensitive trouble/deficit
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • acute ischemia of the lower limbs
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • chronic skin infection/ulcerations/ulcers/cancrum

Drugs & Therapeutics for Thromboangiitis Obliterans

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Thromboangiitis Obliterans

Drug clinical trials:

Search ClinicalTrials for Thromboangiitis Obliterans

Search NIH Clinical Center for Thromboangiitis Obliterans

Search CenterWatch for Thromboangiitis Obliterans

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Thromboangiitis Obliterans cell therapies at LifeMap Discovery.

Genetic Tests for Thromboangiitis Obliterans

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Anatomical Context for Thromboangiitis Obliterans

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Thromboangiitis Obliterans:

32
Bone, Skin, Endothelial, Bone marrow, Colon, Spinal cord, Heart, Kidney

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Thromboangiitis Obliterans:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Thromboangiitis Obliterans or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thromboangiitis Obliterans:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8MMP9, NOS3, SERPINB1
2MP:00053858.8TIMP1, EDN1, NOS3, VCAM1, SELE
3MP:00053698.4ICAM1, HTR2A, MMP9, NOS3
4MP:00053817.8ICAM1, HTR2A, EDN1, MMP9, PLAT, NOS3
5MP:00053786.9ICAM1, MMP9, PLAT, NOS3, VCAM1, SELE
6MP:00053976.5TIMP1, ICAM1, MMP9, PLAT, NOS3, VCAM1
7MP:00053876.5TIMP1, ICAM1, MMP9, PLAT, NOS3, VCAM1
8MP:00053765.7SERPINB1, TIMP1, ICAM1, APOH, EDN1, MMP9
9MP:00107685.7EDN1, APOH, ICAM1, TIMP1, MMP9, PLAT

Publications for Thromboangiitis Obliterans

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Sources:
50PubMed
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Articles related to Thromboangiitis Obliterans:

(show top 50)    (show all 297)
idTitleAuthorsYear
1
Temporal artery involvement as the presenting sign of thromboangiitis obliterans. (23519182)
2013
2
Impaired endothelial-dependent and endothelium-independent vasodilatation in patients with thromboangiitis obliterans. (22311632)
2013
3
Hyperhomocysteinemia as a consequence of life style among patients suffering from thromboangiitis obliterans. (23822948)
2013
4
Successful treatment of thromboangiitis obliterans (Buerger's disease) with immunoadsorption: results of a pilot study. (21380608)
2011
5
Thromboangiitis obliterans involving the temporal artery. (21360696)
2011
6
Classification of corkscrew collaterals in thromboangiitis obliterans (Buerger's disease): relationship between corkscrew type and prevalence of ischemic ulcers. (20534945)
2010
7
Thromboangiitis obliterans in the 21st century--a new face of disease. (19269635)
2009
8
Etiopathogenesis, clinical diagnosis and treatment of thromboangiitis obliterans - current practices. (22477511)
2009
9
Therapeutic angiogenesis in Buerger's disease (thromboangiitis obliterans) patients with critical limb ischemia by autologous transplantation of bone marrow mononuclear cells. (19084740)
2008
10
TCM treatment of thromboangiitis obliterans--a report of 64 cases. (15889520)
2005
11
The altered hemorheologic parameters in thromboangiitis obliterans: a new insight. (14979404)
2004
12
Inflammatory arthritis associated with thromboangiitis obliterans. (17041420)
2003
13
Thromboangiitis obliterans in a young male. (15266926)
2003
14
Expression of ICAM-1, VCAM-1, E-selectin and TNF-alpha on the endothelium of femoral and iliac arteries in thromboangiitis obliterans. (12086338)
2002
15
Antiphospholipid antibodies in thromboangiitis obliterans. (12710840)
2002
16
Distribution of arterial involvement in thromboangiitis obliterans (Buerger's disease): results of a study conducted by the Intractable Vasculitis Syndromes Research Group in Japan. (10930225)
2000
17
Current status of thromboangiitis obliterans (Buerger's disease) in Japan. (10980360)
2000
18
Thromboangiitis obliterans (Buerger's disease). (10995867)
2000
19
Thromboangiitis Obliterans (Buerger's Disease). (11096525)
2000
20
Implantable spinal cord stimulator to treat the ischemic manifestations of thromboangiitis obliterans (Buerger's disease). (10231644)
1999
21
Omentum autotransplantation in thromboangiitis obliterans: report of three cases. (9934840)
1999
22
Chronic ulcerations in the upper and lower extremities. Thromboangiitis obliterans (Buerger disease) (9722735)
1998
23
Thromboangiitis obliterans (Buerger's disease). (9189999)
1997
24
Colonic ischemia reveals thromboangiitis obliterans (Buerger's disease). (8608901)
1996
25
Thromboangiitis obliterans (Buerger's disease) in women (a reevaluation). (8328680)
1993
26
Thromboangiitis obliterans associated with coeliac disease. (8076045)
1993
27
Thromboangiitis obliterans--an autoimmune disorder? (6835341)
1983
28
Sensitivity to collagen in thromboangiitis obliterans. (6888474)
1983
29
Blood zinc levels in patients with arteriosclerosis obliterans, thromboangiitis obliterans and Takayasu's disease. (241871)
1975
30
Early inflammatory changes in thromboangiitis obliterans. (1228574)
1975
31
Lipid metabolism of the arterial wall in thromboangiitis obliterans (Buerger's disease). (814703)
1975
32
Effects of lumbar sympathectomy on thromboangiitis obliterans. (1184672)
1975
33
Thromboangiitis obliterans in a woman. Report of a case. (4694885)
1973
34
Is a new physiopathologic interpretation of obstructive diseases of the arteries possible? Two cases of thromboangiitis obliterans treated with polarizing solution and coronary vasodilators. (4973295)
1968
35
Some hematologic differences between thromboangiitis obliterans and atherosclerosis. (5677577)
1968
36
Thromboangiitis obliterans. Simultaneous quadrilateral acute ulcerations in thromboangiitis obliterans. Follow-up studies of a case after 27 years. (5902104)
1966
37
THROMBOANGIITIS OBLITERANS. CLINICO-ANGIOGRAPHIC CORRELATIONS. (14120715)
1964
38
Thromboangiitis obliterans of the spermatic cord. (13854097)
1960
39
Thromboangiitis obliterans affecting women; report of a case and review of the literature. (13637413)
1959
40
Electrocardiography after hemi-adrenalectomy & lumbar ganglionectomy for thromboangiitis obliterans]. (13501561)
1957
41
XIII. Thromboangiitis obliterans (Buerger's disease). (13310400)
1956
42
Deep venous thrombosis and pulmonary infarction occurring as premonitory symptoms of thromboangiitis obliterans. (13178945)
1954
43
Thromboangiitis obliterans in two brothers. (14952874)
1952
44
Thromboangiitis obliterans; results of sympathectomy. (13011457)
1952
45
Primary involvement of the upper extremities in thromboangiitis obliterans. (14867831)
1951
46
A follow-up study of patient with thromboangiitis obliterans (Buerger's disease). (15395864)
1949
47
A case of thromboangiitis obliterans in an African woman. (18129442)
1949
48
Further experience with thromboangiitis obliterans in women. (18889851)
1948
49
Use of trichophytin in thromboangiitis obliterans. (20292639)
1947
50
The diagnosis of thromboangiitis obliterans and peripheral arteriosclerosis. (21007317)
1945

Genetic Variations for Thromboangiitis Obliterans

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Expression for genes affiliated with Thromboangiitis Obliterans

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thromboangiitis Obliterans

Search GEO for disease gene expression data for Thromboangiitis Obliterans.

Pathways for genes affiliated with Thromboangiitis Obliterans

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Sources:
4Cell Signaling Technology, 51QIAGEN, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore
See all sources

Pathways related to Thromboangiitis Obliterans according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8VCAM1, ICAM1
29.8ICAM1, VCAM1
39.6SERPINE1, PLAT
49.6SELE, VCAM1, ICAM1
59.6SELE, VCAM1, ICAM1
6
Hide members
9.4SERPINE1, VCAM1, ICAM1
79.3MMP9, NOS3
89.2MMP9, PLAT
99.2ICAM1, PLAT, SERPINE1
10
Hide members
9.2ICAM1, NOS3, VCAM1, SELE
11
Hide members
9.0PLAT, NOS3, SELE, SERPINE1
129.0VCAM1, MMP9, ICAM1
138.9PLAT, MMP9, ICAM1
148.7SERPINE1, NOS3, EDN1, TIMP1
158.7NOS3, MMP9, TIMP1
16
Hide members
8.5SERPINE1, VCAM1, MMP9, ICAM1
178.4SELE, VCAM1, MMP9, EDN1, ICAM1
18
Cell adhesion ECM remodeling
Hide members
8.2TIMP1, MMP9, PLAT, SERPINE1
19
Hide members
7.5ICAM1, HTR2A, EDN1, MMP9, PLAT, VCAM1

Compounds for genes affiliated with Thromboangiitis Obliterans

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Thromboangiitis Obliterans according to GeneCards/GeneDecks:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.5HTR2A
2cyclophosphamide44 49 1112.0APOH, NOS3
3rosiglitazone44 49 28 11 2414.0TIMP1, VCAM1
4aspartate449.9SELE, VCAM1
5matrigel449.9NOS3, SERPINE1, SELE
6pge2449.7MMP9
7carvedilol44 49 28 1112.6VCAM1, NOS3, EDN1, SELE
8nebivolol44 1110.6NOS3, SERPINE1, EDN1
9gliclazide44 49 1111.5SELE, VCAM1, PLAT, ICAM1
10iloprost44 59 28 1112.5SELE, VCAM1, PLAT, EDN1
11polymyxin b449.4SERPINE1, ICAM1, SELE, VCAM1
12quinapril44 1110.4PLAT, SERPINE1, SELE, EDN1
13losartan44 49 28 1112.4EDN1, PLAT, SELE, SERPINE1
14apocynin44 5910.3SELE, EDN1, NOS3, ICAM1, VCAM1
15heparin44 28 11 2412.1SELE, VCAM1, APOH, TIMP1
16pravastatin44 49 28 11 2413.1SERPINE1, SELE, VCAM1, NOS3, ICAM1
17sodium nitroprusside449.0SERPINE1, EDN1, PLAT, NOS3, VCAM1
18hirudin449.0TIMP1, PLAT, SERPINE1, SELE
19isoproterenol44 119.9SELE, SERPINE1, VCAM1, PLAT, EDN1
20l-nmma448.8EDN1, MMP9, NOS3, VCAM1
21endotoxin448.8ICAM1, APOH, VCAM1, SELE, SERPINE1
22ciglitazone44 289.8MMP9, NOS3, ICAM1, SERPINE1
23omapatrilat448.8PLAT, MMP9, EDN1
24homocysteine44 249.6APOH, SERPINE1, SELE, PLAT, NOS3, VCAM1
25creatinine448.6MMP9, SELE, APOH
26histamine44 28 2410.5ICAM1, TIMP1, EDN1, PLAT, VCAM1, SELE
27fenofibrate44 49 1110.4SERPINE1, ICAM1, MMP9, NOS3, VCAM1, SELE
28cytochalasin d44 599.4VCAM1, MMP9, ICAM1, SELE, TIMP1
29nicotine44 49 28 1111.3ICAM1, SERPINE1, MMP9, PLAT, SELE
30troglitazone44 28 59 1111.3MMP9, SERPINE1, VCAM1, PLAT, SELE, ICAM1
31aspirin44 49 28 2411.3SELE, TIMP1, APOH, PLAT, NOS3, SERPINE1
32nifedipine44 49 28 1111.3SERPINE1, MMP9, SELE, EDN1, TIMP1
33herbimycin a44 599.2EDN1, MMP9, VCAM1, SELE, ICAM1, TIMP1
34folate448.0NOS3, VCAM1, SELE, APOH, TIMP1, MMP9
35fluvastatin44 49 28 1111.0SERPINE1, SELE, VCAM1, NOS3, PLAT, MMP9
36simvastatin44 49 59 28 11 2413.0PLAT, NOS3, VCAM1, SELE, SERPINE1, MMP9
37methotrexate44 49 119.8SERPINE1, SELE, NOS3, MMP9, APOH, TIMP1
38fibrinogen447.8PLAT, SELE, MMP9, ICAM1, APOH, VCAM1
39ly294002447.7MMP9, TIMP1, ICAM1, SERPINE1, NOS3, VCAM1
40nitric oxide44 11 249.7VCAM1, SELE, NOS3, APOH, ICAM1, EDN1
41pd 98,059447.7ICAM1, EDN1, MMP9, TIMP1, NOS3, VCAM1
42lactate447.6TIMP1, APOH, MMP9, VCAM1, SELE, ICAM1
438-isoprostane447.5SERPINE1, SELE, VCAM1, NOS3, MMP9, EDN1
44sb 20358044 598.4ICAM1, SERPINE1, TIMP1, SELE, VCAM1, NOS3
45genistein44 28 59 2 11 2412.4ICAM1, SERPINE1, NOS3, TIMP1, SELE, EDN1
46phosphatidylinositol447.4NOS3, MMP9, VCAM1, EDN1, ICAM1, TIMP1
47prostacyclin447.3SERPINE1, SELE, VCAM1, NOS3, PLAT, EDN1
48actinomycin d447.3SELE, SERPINE1, TIMP1, ICAM1, EDN1, MMP9
49atorvastatin44 49 28 11 2411.0ICAM1, NOS3, VCAM1, SELE, PLAT, MMP9
50vegf446.9VCAM1, ICAM1, TIMP1, MMP9, APOH, EDN1

GO Terms for genes affiliated with Thromboangiitis Obliterans

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16Gene Ontology
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Cellular components related to Thromboangiitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1caveolaGO:0059019.3HTR2A, NOS3, SELE
2extracellular matrixGO:0310129.1SERPINE1, PLAT, APOH
3extracellular spaceGO:0056156.4SERPINB1, ICAM1, APOH, EDN1, MMP9, PLAT

Biological processes related to Thromboangiitis Obliterans according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.1ICAM1, VCAM1
2regulation of systemic arterial blood pressure by endothelinGO:00310010.1EDN1, NOS3
3leukocyte tethering or rollingGO:05090110.1VCAM1, SELE
4negative regulation of potassium ion transportGO:04326710.0HTR2A, NOS3
5negative regulation of calcium ion transportGO:05192610.0ICAM1, NOS3
6negative regulation of smooth muscle cell apoptotic processGO:0343929.9APOH, EDN1
7negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.9SERPINE1, NOS3
8leukocyte cell-cell adhesionGO:0071599.9ICAM1, VCAM1, SELE
9heterophilic cell-cell adhesionGO:0071579.9SELE, VCAM1, ICAM1
10phosphatidylinositol 3-kinase cascadeGO:0140659.8EDN1, HTR2A
11plasminogen activationGO:0316399.8PLAT, APOH
12negative regulation of fibrinolysisGO:0519189.7SERPINE1, APOH
13fibrinolysisGO:0427309.6SERPINE1, PLAT
14positive regulation of blood coagulationGO:0301949.6APOH, SERPINE1
15agingGO:0075689.5TIMP1, HTR2A, VCAM1
16positive regulation of vasoconstrictionGO:0459079.5HTR2A, ICAM1
17negative regulation of blood coagulationGO:0301959.5SERPINE1, EDN1, APOH
18response to hypoxiaGO:0016669.3EDN1, PLAT, VCAM1
19blood coagulationGO:0075968.7TIMP1, PLAT, NOS3, SELE, SERPINE1

Molecular functions related to Thromboangiitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.3SERPINE1, SELE, NOS3, PLAT, MMP9, EDN1

Products for genes affiliated with Thromboangiitis Obliterans

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  • Antibodies
  • Proteins
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Sources for Thromboangiitis Obliterans

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet