MCID: THR006
MIFTS: 60

Thromboangiitis Obliterans malady

Rare diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases, Blood diseases categories

Aliases & Classifications for Thromboangiitis Obliterans

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Sources:
32LifeMap Discovery®, 10Disease Ontology, 45NIH Rare Diseases, 51Orphanet, 65UMLS, 36MeSH, 47Novoseek, 29ICD9CM, 59SNOMED-CT, 42NCIt, 28ICD10 via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Thromboangiitis Obliterans:

Name: Thromboangiitis Obliterans 32 10 45 51 65 36
Buerger Disease 45 47 51
Buerger's Disease 10 45
Inflammatory Occlusive Peripheral Vascular Disease 45
 
Occlusive Peripheral Vascular Disease 45
Thromboangiitis Obliterans Nos 10
Presenile Gangrene 10
Tao 45


Classifications:



Characteristics (Orphanet epidemiological data):

51
thromboangiitis obliterans:
Prevalence: 1-5/10000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Disease Ontology10 DOID:12918
ICD9CM29 443.1
NCIt42 C35070
MeSH36 D013919
Orphanet51 36258
ICD10 via Orphanet28 I73.1
ICD1027 I73.1

Summaries for Thromboangiitis Obliterans

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NIH Rare Diseases:45 Buerger disease is a disease of the arteries and veins in the arms and legs. the arteries and veins become inflamed which can lead to narrowed and blocked vessels. this reduces blood flow resulting in pain and eventually damage to affected tissues. buerger disease nearly always occurs in association with cigarette or other tobacco use. quitting all forms of tobacco is an essential part of treatment. last updated: 6/16/2015

MalaCards based summary: Thromboangiitis Obliterans, also known as buerger disease, is related to limb ischemia and artery disease, and has symptoms including chronic skin infection/ulcerations/ulcers/cancrum, arterial embolism/thrombosis and arterial pulse abolition. An important gene associated with Thromboangiitis Obliterans is NOS3 (Nitric Oxide Synthase 3 (Endothelial Cell)), and among its related pathways are Immune response_Role of integrins in NK cells cytotoxicity and Immune response_MIF-mediated glucocorticoid regulation. The drugs isoxsuprine and tolazoline have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and skin, and related mouse phenotypes are vision/eye and skeleton.

Wikipedia:68 Thromboangiitis obliterans (also known as Buerger\'s disease, Buerger disease [English /bʌrɡər/;... more...

Related Diseases for Thromboangiitis Obliterans

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Diseases related to Thromboangiitis Obliterans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 250)
idRelated DiseaseScoreTop Affiliating Genes
1limb ischemia31.0ICAM1, VCAM1
2artery disease29.9EDN1, ICAM1, MMP9, SELE, VCAM1
3ischemic bone disease29.7EDN1, ICAM1, NOS3, VEGFA
4pre-malignant neoplasm29.6EDN1, NOS3, VCAM1, VEGFA
5rheumatoid arthritis29.1ICAM1, MMP9, SELE, VCAM1, VEGFA
6cerebritis10.8
7arteriosclerosis10.7
8ischemia10.7
9endotheliitis10.7
10arteriosclerosis obliterans10.6
11atherosclerosis10.6
12thrombophlebitis10.6
13vascular disease10.6
14vasculitis10.5
15critical limb ischemia10.4
16hyperhomocysteinemia10.4
17peripheral artery disease10.4
18thyroiditis10.3
19peripheral vascular disease10.2
20arthritis10.2
21dilated cardiomyopathy10.2
22ischemic heart disease10.2
23paronychia10.2
24cryoglobulinemia10.2
25aphthous stomatitis10.2
26thrombotic thrombocytopenic purpura10.2
27hypoglycemia10.2
28pain disorder10.2
29chronic venous insufficiency10.2
30cellulitis10.2
31diarrhea10.2
32eosinophilia10.2
33impotence10.2
34pulmonary embolism10.2
35purpura10.2
36thrombophilia10.2
37venous insufficiency10.2
38cardiomyopathy10.2
39hypoxia10.2
40maxillary sinus inverted papilloma10.2ICAM1, VCAM1
41inappropriate adh syndrome10.2ICAM1, VCAM1
42cutaneous photosensitivity and colitis, lethal10.2SELE, VCAM1
43liver cirrhosis10.2ICAM1, VCAM1
44procarcinoma10.2EDN1, NOS3
45spinal cord lipoma10.2ICAM1, VCAM1
46anaerobic pneumonia10.2ICAM1, SELE
47lumbosacral plexus lesion10.2ICAM1, SELE
48aortic dissection lentiginosis10.2EDN1, NOS3
49postencephalitic parkinson disease10.2ICAM1, SELE
50ventricular septal defect10.2ICAM1, VCAM1

Graphical network of the top 20 diseases related to Thromboangiitis Obliterans:



Diseases related to thromboangiitis obliterans

Symptoms for Thromboangiitis Obliterans

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Symptoms:

 51 (show all 12)
  • chronic skin infection/ulcerations/ulcers/cancrum
  • arterial embolism/thrombosis
  • arterial pulse abolition
  • vascularitis/vasculitides/arteritis
  • gangrena/necrosis
  • sensitive trouble/deficit
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • acute ischemia of the lower limbs
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • articular/joint pain/arthralgia
  • hyperhidrosis/increased sweating
  • insomnia

Drugs & Therapeutics for Thromboangiitis Obliterans

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Drugs for Thromboangiitis Obliterans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1CitrateNutraceuticalPhase 1, Phase 2784
2
Citric AcidnutraceuticalPhase 1, Phase 278477-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
3
Bosentanapproved, investigational99147536-97-8104865
Synonyms:
-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
AC-148
AC1L2XN2
Actelion
Bosentan
Bosentan (INN)
Bosentan [USAN:INN:BAN]
Bosentan hydrate
Bosentanum
C27H29N5O6S
CHEBI:51450
CHEMBL957
CID104865
D07538
 
DB00559
EN002863
HMS2090N14
I06-1873
KS-5062
L001086
LS-31532
MolPort-003-845-300
NCGC00167440-01
P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
UNII-XUL93R30K2
bosentanum
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
p-tert-Butyl-N-[6-(2-hydroxyethoxy)

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Buerger's DiseaseCompletedNCT01302015Phase 1, Phase 2
2Autologous Endothelial Progenitor Cells (EPCs) From Peripheral Blood in the Treatment of Critical Limb IschemiaCompletedNCT01595776Phase 1, Phase 2
3A Clinical Trial to Study the Efficacy and Safety of Different Doses of Bone Marrow Derived Mesenchymal Stem Cells in Patients With Critical Limb Ischemia Due to Buergers DiseaseRecruitingNCT01484574Phase 2
4TACT-NAGOYA: Therapeutic Angiogenesis Using Cell TransplantationRecruitingNCT00145262Phase 2
5Safety and Efficacy Study of Autologous BM-MNC Processed by Two Methods for Treating Patients With Chronic Limb IschemiaNot yet recruitingNCT01446055Phase 1, Phase 2
6Study to Assess the Efficacy and Safety of CLBS12 in Patients With Critical Limb Ischemia (CLI)Not yet recruitingNCT02501018Phase 2
7Treatment of Thromboangiitis Obliterans (Buerguer's Disease) With BosentanCompletedNCT01447550
8Contrast Enhanced Ultrasound and MuscleCompletedNCT02128750
9ADDICTAO: Psychological and Addictive Profile of Patients With Buerger's DiseaseRecruitingNCT01064206
10Purified CD34+ Cells Versus Peripheral Blood Mononuclear Cells in Treatment of Critical Limb IschemiaRecruitingNCT02089828
11Evaluation of a Combined Parent-student Programme for Smoking Prevention in Berlin SchoolsRecruitingNCT01306552

Search NIH Clinical Center for Thromboangiitis Obliterans

Inferred drug relations via UMLS65/NDF-RT43:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Thromboangiitis Obliterans cell therapies at LifeMap Discovery.

Genetic Tests for Thromboangiitis Obliterans

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Anatomical Context for Thromboangiitis Obliterans

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MalaCards organs/tissues related to Thromboangiitis Obliterans:

33
Bone, Endothelial, Skin, Bone marrow, Colon, Neutrophil, Spinal cord

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Thromboangiitis Obliterans:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Thromboangiitis Obliterans or affiliated genes

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MGI Mouse Phenotypes related to Thromboangiitis Obliterans:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.0ICAM1, MMP9, NOS3, SELE, VEGFA
2MP:00053908.0EDN1, HTR2A, MMP9, NOS3, VEGFA
3MP:00053797.8EDN1, HTR2A, ICAM1, NOS3, VEGFA
4MP:00053817.5EDN1, HTR2A, ICAM1, MMP9, NOS3, VEGFA
5MP:00053697.5EDN1, HTR2A, ICAM1, MMP9, NOS3, VEGFA
6MP:00053877.4ICAM1, MMP9, NOS3, SELE, VCAM1, VEGFA
7MP:00053977.2ICAM1, MMP9, NOS3, SELE, VCAM1, VEGFA
8MP:00053857.2EDN1, ICAM1, MMP9, NOS3, SELE, VCAM1
9MP:00107687.2EDN1, ICAM1, MMP9, NOS3, SELE, VCAM1
10MP:00053767.0EDN1, ICAM1, MMP9, NOS3, SELE, VCAM1

Publications for Thromboangiitis Obliterans

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Articles related to Thromboangiitis Obliterans:

(show top 50)    (show all 317)
idTitleAuthorsYear
1
Integrated treatment for lower-limb stage II thromboangiitis obliterans by interventional therapy and oral administration of Chinese medicine: a randomized controlled clinical trial. (25842727)
2015
2
End stage renal disease caused by thromboangiitis obliterans: a case report. (26286269)
2015
3
Buerger Disease (Thromboangiitis Obliterans). (25770636)
2014
4
The value of FDG-PET in the diagnosis of thromboangiitis obliterans-a case series. (24794493)
2014
5
Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost. (25005765)
2014
6
Temporal artery involvement as the presenting sign of thromboangiitis obliterans. (23519182)
2013
7
Imbalanced matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 activities in patients with thromboangiitis obliterans. (22402936)
2012
8
Buerger's disease (Thromboangiitis obliterans): a diagnostic challenge. (22679237)
2011
9
Buerger's Disease (Thromboangiitis Obliterans)- Management by Ilizarov's Technique of Horizontal Distraction. A Retrospective Study of 60 Cases. (22211037)
2011
10
Effectiveness of bosentan in the treatment of ischemic lesions in a case of thromboangiitis obliterans (Buerger disease): a case report. (21810389)
2011
11
Protective effect of Shenfu injection on thromboangiitis obliterans model rats. (21982791)
2011
12
Color doppler flows of corkscrew collaterals in Thromboangiitis obliterans (Buerger's disease) using color duplex ultrasonography. (21679855)
2011
13
Classification of corkscrew collaterals in thromboangiitis obliterans (Buerger's disease): relationship between corkscrew type and prevalence of ischemic ulcers. (20534945)
2010
14
Thromboangiitis obliterans and endothelial function. (20584171)
2010
15
Treatment of Buerger disease (thromboangiitis obliterans) with bosentan: a case report. (21686681)
2009
16
Thromboangiitis obliterans in the 21st century--a new face of disease. (19269635)
2009
17
A prospective, case-control study of tobacco dependence in thromboangiitis obliterans (Buerger's Disease). (16444459)
2006
18
One of the most frequent vascular diseases in northeastern of Turkey: Thromboangiitis obliterans or Buerger's disease (experience with 344 cases). (16580754)
2006
19
Thromboangiitis obliterans associated with peripheral blood and eosinophilic cellulitis-like skin lesions. (15985040)
2005
20
Distribution of arterial involvement in thromboangiitis obliterans (Buerger's disease): results of a study conducted by the Intractable Vasculitis Syndromes Research Group in Japan. (10930225)
2000
21
Current status of thromboangiitis obliterans (Buerger's disease) in Japan. (10980360)
2000
22
Implantable spinal cord stimulator to treat the ischemic manifestations of thromboangiitis obliterans (Buerger's disease). (10231644)
1999
23
Study of anti-neutrophil cytoplasmic antibodies in patients with thromboangiitis obliterans (Buerger's disease). (9822265)
1998
24
Is the capillary microscopic determination of the visible capillary length a diagnostic criterion in thromboangiitis obliterans? (9612111)
1998
25
Inpatient treatment of severe nicotine dependence in a patient with thromboangiitis obliterans (Buerger's disease). (9621859)
1998
26
Thromboangiitis obliterans (Buerger's disease) in visceral vessels confirmed by angiographic and histological findings. (9854560)
1998
27
Thromboangiitis obliterans (Buerger's disease). (9189999)
1997
28
Pharmacokinetics and tolerability of oral iloprost in thromboangiitis obliterans patients. (9349930)
1997
29
Thromboangiitis obliterans (Buerger's disease) (9119522)
1996
30
Case of thromboangiitis obliterans (Buerger's disease) of the upper lip. (7573750)
1995
31
Impotence as a cardinal sign in the thromboangiitis obliterans diagnosis. (8608695)
1995
32
Cerebral thromboangiitis obliterans: clinical and MRI findings in a case. (7671993)
1995
33
Thromboangiitis obliterans. (7518238)
1994
34
Buerger's disease (thromboangiitis obliterans). (2189162)
1990
35
Serum zinc and copper in patients with atherosclerosis and thromboangiitis obliterans. (2484753)
1989
36
CAT scan and immunohistochemical findings in a case of cerebral thromboangiitis obliterans (Buerger's disease). (6714279)
1984
37
Cellular sensitivity to collagen in thromboangiitis obliterans. (6835334)
1983
38
Buerger's disease (thromboangiitis obliterans): an analysis of the arteriograms of 119 cases. (7067357)
1982
39
Autoantibodies in thromboangiitis obliterans (Buerger's disease). (6751163)
1982
40
Factors influenced on prognosis of reconstructive surgery for peripheral arterial occlusion: comparative study between arteriosclerosis obliterans and thromboangiitis obliterans. (599159)
1977
41
Traditional chinese medicine in the treatment of thromboangiitis obliterans. Report of 136 cases. (5678364)
1968
42
Coexistence of thromboangiitis obliterans and arteriosclerosis: relationship to smoking. (5914684)
1966
43
Thromboangiitis obliterans and arteriosclerosis obliterans. (5833515)
1965
44
THROMBOANGIITIS OBLITERANS AND ARTERIOSCLEROSIS OBLITERANS. CLINICAL AND PROGNOSTIC DIFFERENCES. (14065946)
1963
45
Cogan's syndrome and systemic vascular disease. Analysis of pathologic features with reference to its relationship to thromboangiitis obliterans (Buerger). (13893233)
1961
46
Thromboangiitis obliterans: a 30-year study. (13502019)
1958
47
Thromboangiitis obliterans in two brothers. (14952874)
1952
48
A follow-up study of patient with thromboangiitis obliterans (Buerger's disease). (15395864)
1949
49
Cerebral thromboangiitis obliterans. (20289123)
1947
50
Treatment of thromboangiitis obliterans. (21006071)
1945

Variations for Thromboangiitis Obliterans

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Expression for genes affiliated with Thromboangiitis Obliterans

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Search GEO for disease gene expression data for Thromboangiitis Obliterans.

Pathways for genes affiliated with Thromboangiitis Obliterans

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Pathways related to Thromboangiitis Obliterans according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ICAM1, VCAM1
29.7ICAM1, VCAM1
39.7ICAM1, VCAM1
49.6EDN1, NOS3
59.6MMP9, NOS3
69.6MMP9, NOS3
79.5MMP9, SELE
89.2ICAM1, SELE, VCAM1
99.2ICAM1, SELE, VCAM1
109.2ICAM1, SELE, VCAM1
119.2ICAM1, MMP9, VCAM1
129.2ICAM1, MMP9, VCAM1
13
Show member pathways
9.1EDN1, VEGFA
149.1MMP9, VEGFA
15
VEGF Pathway (Qiagen)
Show member pathways
8.9MMP9, VEGFA
168.9ICAM1, NOS3, SELE, VCAM1
178.8EDN1, NOS3, VEGFA
188.8EDN1, NOS3, VEGFA
19
Angiogenesis (WikiPathways)
Show member pathways
8.8EDN1, NOS3, VEGFA
20
Show member pathways
8.5NOS3, SELE, VCAM1, VEGFA
218.2EDN1, ICAM1, MMP9, SELE, VCAM1
22
Show member pathways
8.1ICAM1, NOS3, SELE, VCAM1, VEGFA
23
Show member pathways
7.6EDN1, HTR2A, MMP9, NOS3, VEGFA

GO Terms for genes affiliated with Thromboangiitis Obliterans

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Cellular components related to Thromboangiitis Obliterans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1caveolaGO:00059019.6HTR2A, NOS3, SELE
2extracellular spaceGO:00056157.4EDN1, ICAM1, MMP9, SELE, VCAM1, VEGFA

Biological processes related to Thromboangiitis Obliterans according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of calcium ion transportGO:005192610.4ICAM1, NOS3
2negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.3ICAM1, NOS3
3membrane to membrane dockingGO:002261410.3ICAM1, VCAM1
4regulation of systemic arterial blood pressure by endothelinGO:000310010.3EDN1, NOS3
5leukocyte tethering or rollingGO:005090110.2SELE, VCAM1
6negative regulation of potassium ion transportGO:004326710.1HTR2A, NOS3
7artery smooth muscle contractionGO:001482410.0EDN1, HTR2A
8response to amino acidGO:004320010.0EDN1, ICAM1
9phosphatidylinositol 3-kinase signalingGO:00140659.9EDN1, HTR2A
10calcium-mediated signalingGO:00197229.8EDN1, SELE
11positive regulation of nitric oxide biosynthetic processGO:00454299.8EDN1, ICAM1
12positive regulation of vasoconstrictionGO:00459079.8HTR2A, ICAM1
13positive regulation of leukocyte migrationGO:00026879.7SELE, VEGFA
14heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:00071579.7ICAM1, SELE, VCAM1
15endothelial cell migrationGO:00435429.7NOS3, VEGFA
16leukocyte cell-cell adhesionGO:00071599.7ICAM1, SELE, VCAM1
17positive regulation of receptor internalizationGO:00020929.7SELE, VEGFA
18positive regulation of endothelial cell migrationGO:00105959.7EDN1, VEGFA
19macrophage differentiationGO:00302259.5MMP9, VEGFA
20ovarian follicle developmentGO:00015419.5ICAM1, VEGFA
21response to lipopolysaccharideGO:00324969.5EDN1, ICAM1, SELE
22leukocyte migrationGO:00509009.4ICAM1, MMP9, SELE
23extracellular matrix organizationGO:00301989.2ICAM1, MMP9, VCAM1
24in utero embryonic developmentGO:00017019.2EDN1, NOS3, VEGFA
25patterning of blood vesselsGO:00015699.1EDN1, VEGFA
26positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.0HTR2A, ICAM1, VEGFA
27cellular response to hypoxiaGO:00714568.9EDN1, ICAM1, VEGFA
28response to hypoxiaGO:00016668.9EDN1, ICAM1, VEGFA
29positive regulation of ERK1 and ERK2 cascadeGO:00703748.9HTR2A, ICAM1, VEGFA
30blood vessel morphogenesisGO:00485148.8EDN1, VEGFA
31positive regulation of MAP kinase activityGO:00434068.8EDN1, HTR2A, VEGFA

Sources for Thromboangiitis Obliterans

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet