MCID: THR014
MIFTS: 70

Thrombocytopenia malady

Genetic diseases, Blood diseases, Rare diseases, Immune diseases, Fetal diseases categories
Download this MalaCard

Summaries for Thrombocytopenia

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 The terms thrombocytopenia and thrombopenia, refer to a relative decrease of platelets in blood. more...

MalaCards: Thrombocytopenia, also known as platelet count below reference range, is related to thrombocytopenia-absent radius syndrome and x-linked thrombocytopenia. An important gene associated with Thrombocytopenia is WAS (Wiskott-Aldrich syndrome), and among its related pathways are Articular Cartilage Extracellular Matrix and Platelet Adhesion to exposed collagen. The drugs lepirudin and interferon alfa-2a and the compounds megapoietin and anagrelide have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related mouse phenotypes are embryogenesis and renal/urinary system.

Aliases & Classifications for Thrombocytopenia

About this section
Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM
See all sources

Classifications:



Aliases & Descriptions:

thrombocytopenia 8 10 45 31 62
platelet count below reference range 8


External Ids:

Disease Ontology8 DOID:1588
NCIt40 C3408
MeSH35 D013921
ICD9CM27 287.5

Related Diseases for Thrombocytopenia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Myh9 Related Thrombocytopenia family:

Thrombocytopenia Due to Platelet Alloimmunization Acquired Thrombocytopenia
thrombocytopenia Thrombocytopenia 2
Mastl-Related Thrombocytopenia 2 Thrombocytopenia 4
Ankrd26-Related Thrombocytopenia 2 Gata1-Related Thrombocytopenia

Diseases related to Thrombocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 577)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia-absent radius syndrome31.1THPO
2x-linked thrombocytopenia31.1WAS, THPO, GATA1
3purpura31.0THPO
4congenital amegakaryocytic thrombocytopenia30.9IL3, MPL, THPO
5wiskott-aldrich syndrome30.9GATA1, WAS, THPO
6splenomegaly30.5THPO, MPL
7thrombocytopenia 230.5ANKRD26
8von willebrand's disease30.5GP1BA, ITGA2B
9thrombocytopenia due to platelet alloimmunization30.4ITGA2B, MPL, THPO
10neutropenia30.4WAS, IL3, MPL, THPO
11leukemia30.4GATA1, MPL, ITGB3, ITGA2B, IL3, HOXA11
12autoimmune thrombocytopenic purpura30.4GP1BA, MPL, THPO, ITGB3
13thrombocytosis30.3THPO, GP1BA, MPL, IL3
14gray platelet syndrome30.3GATA1
15myelofibrosis30.3MPL, THPO
16myelodysplastic syndromes30.2GATA1, IL3, MPL, THPO, GP1BA
17myocardial infarction30.1ITGB3, GP1BA, CYCS, ITGA2B, ITGA2
18myeloid leukemia30.1THPO, GATA1, IL3, MPL, CFI, CYCS
19liver cirrhosis30.1ITGB3, THPO, MPL
20coronary thrombosis30.1ITGB3
21glanzmann's thrombasthenia30.0ITGB3, ITGA2B
22bernard-soulier syndrome30.0ITGA2, ITGA2B, ITGB3, GP1BA, THPO
23breast cancer30.0GATA1, ITGA2, GP1BA, CYCS
24acute leukemia30.0THPO, GATA1, MPL, IL3
25polycythemia29.9MPL, ITGB3, IL3, THPO
26polycythemia vera29.9IL3, ITGB3, MPL, THPO
27pancytopenia29.9THPO, MPL, IL3
28aplastic anemia29.9IL3, THPO, MPL, GP1BA, GATA1
29deficiency anemia29.9MPL, IL3, THPO, GATA1
30rheumatoid arthritis29.8THPO, CFI, ITGA2, ITGB3
31ovarian cancer29.8CYCS, CFI, IL3, ITGA2, ITGB3
32acute lymphocytic leukemia29.8GATA1, MPL, THPO, IL3
33chronic myeloid leukemia29.7THPO, GATA1, IL3, ITGB3, MPL
34vascular disease29.6ITGA2, ITGB3, GP1BA
35myeloproliferative disorder29.5ITGB3, GATA1, IL3, MPL, THPO
36heparin-induced thrombocytopenia11.2
37leukopenia10.6
38hepatitis10.6
39cyclic thrombocytopenia10.6
40hemolytic anemia10.5
41hepatitis c10.4
42malaria10.4
43hemangioma10.4
44lupus erythematosus10.4
45systemic lupus erythematosus10.4
46hemangioma thrombocytopenia syndrome10.4
47hemorrhagic fever10.4
48hypersplenism10.4
49autoimmune hemolytic anemia10.3
50acquired thrombocytopenia10.3

Graphical network of the top 20 diseases related to Thrombocytopenia:



Diseases related to thrombocytopenia

Symptoms for Thrombocytopenia

About this section

Drugs & Therapeutics for Thrombocytopenia

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
See all sources

Genetic Tests for Thrombocytopenia

About this section

Anatomical Context for Thrombocytopenia

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Thrombocytopenia:

33
Liver, Bone, Testes, Bone marrow, T cells, Spleen, Heart, Myeloid, Skin, B cells, Endothelial, Monocytes, Pituitary, Kidney, Breast, Thyroid, Lung, Whole blood, Colon, Pancreas, Ovary, Prostate, Pineal, Placenta

Animal Models for Thrombocytopenia or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Thrombocytopenia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.1MPL, ITGB3, ITGA2B, MASTL, GATA1, CYCS
2MP:00053677.8HOXA11, CFI, WAS, ANKRD26, ITGB3, IL3
3MP:00053876.6THPO, CYCS, MPL, WAS, ITGB3, ITGA2B
4MP:00053766.2WAS, MPL, GP1BA, CFI, ANKRD26, ITGB3
5MP:00053976.1MPL, GP1BA, CYCS, THPO, WAS, ITGB3
6MP:00053846.1GATA1, HOXA11, CYCS, GP1BA, MPL, WAS

Publications for Thrombocytopenia

About this section
Sources:
52PubMed
See all sources

Articles related to Thrombocytopenia:

(show top 50)    (show all 2135)
idTitleAuthorsYear
1
Dental procedures in 24 patients with chronic immune thrombocytopenia in prospective clinical studies of eltrombopag. (24433306)
2014
2
Therapeutic platelet transfusion for hypoproliferative thrombocytopenia - authors' reply. (23472916)
2013
3
Heparin-induced thrombocytopenia associated with thrombotic microangiopathy. (23715106)
2013
4
Argatroban in heparin-induced thrombocytopenia: rationale for use and place in therapy. (24179672)
2013
5
Oral eltrombopag for up to three years is safe and well-tolerated in Japanese patients with previously treated chronic immune thrombocytopenia: an open-label, extension study. (23896965)
2013
6
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
7
The I+IIb p.Leu841Met (Cab3(a+) ) polymorphism results in a new human platelet alloantigen involved in neonatal alloimmune thrombocytopenia. (22738334)
2013
8
A study of cytological changes in the bone marrow of patients with severe Fever with thrombocytopenia syndrome. (24349423)
2013
9
Rapidly Involuting Congenital Hemangioma Associated with Profound, Transient Thrombocytopenia. (22937785)
2012
10
Thrombocytopenia in HIV-Infected Patients. (23730018)
2012
11
Hemodialysis-associated acute systemic reactions and heparin-induced thrombocytopenia. (22127211)
2012
12
Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (22315270)
2012
13
Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus. (22869835)
2012
14
What are the options for anticoagulation needs in dialysis for patients with heparin-induced thrombocytopenia? (21851394)
2011
15
A clinical-laboratory algorithm incorporating optical density value to predict heparin-induced thrombocytopenia. (21264443)
2011
16
Exacerbation of thrombocytopenia in a pregnant woman with thrombocytopenia-absent radius syndrome. (21530967)
2011
17
Novel use of plasmapheresis in a patient with heparin-induced thrombocytopenia requiring urgent insertion of a left ventricular assist device under cardiopulmonary bypass. (20723718)
2010
18
False-positive tests for heparin-induced thrombocytopenia in patients with antiphospholipid syndrome and systemic lupus erythematosus: a rebuttal. (20345710)
2010
19
Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban]. (19795099)
2009
20
Clonal chromosome anomalies and propensity to myeloid malignancies in congenital amegakaryocytic thrombocytopenia (OMIM 604498). (18519517)
2008
21
Serologic results in >1000 patients with suspected heparin-induced thrombocytopenia. (17895512)
2008
22
Successful treatment of autoimmune pancreatitis complicated with autoimmune thrombocytopenia and interstitial pneumonia by prednisolone. (18520116)
2008
23
Spontaneous superior sagittal sinus thrombosis secondary to type II heparin-induced thrombocytopenia presenting as an acute subarachnoid hemorrhage. (17582771)
2007
24
Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit. (17464135)
2007
25
Review article: pharmacological approaches for the treatment of thrombocytopenia in patients with chronic liver disease and hepatitis C infection. (17958517)
2007
26
Detection of 28 novel mutations in the Wiskott-Aldrich syndrome and X-linked thrombocytopenia based on multiplex PCR. (17400488)
2007
27
Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. (16466367)
2006
28
Successful renal transplantation in a patient with heterozygous prothrombin gene, factor V Leiden mutation and heparin-induced thrombocytopenia using r-hirudin as anticoagulant. (16499600)
2006
29
Use of ecarin clotting time in whole blood for monitoring recombinant hirudine treatment during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia]. (15771978)
2005
30
Patterns of thrombocytosis and thrombocytopenia in hospitalized neonates. (15578031)
2005
31
Mayer-Rokitansky-KA1ster-Hauser syndrome associated with thrombocytopenia-absent radius syndrome. (15705390)
2005
32
Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin-induced thrombocytopenia: an analysis of 3 prospective studies. (15280202)
2004
33
Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit. (12477267)
2002
34
Wilson disease manifested primarily as amenorrhea and accompanying thrombocytopenia. (12359384)
2002
35
Treatment of lupus-induced thrombocytopenia with recombinant human interleukin-11. (11212156)
2001
36
Mutations in the thrombopoietin receptor, Mpl, in children with congenital amegakaryocytic thrombocytopenia. (10971406)
2000
37
Sustained response to combination therapy in a patient with chronic hepatitis C and thrombocytopenia secondary to alpha-interferon. (10847447)
2000
38
Further examination of various administration protocols of pegylated recombinant human megakaryocyte growth and development factor on thrombocytopenia in myelosuppressed mice. (10227790)
1998
39
Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production. (8896400)
1996
40
Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia. (8826901)
1996
41
Osteopetrosis, anemia, thrombocytopenia, and marrow necrosis in beef calves naturally infected with bovine virus diarrhea virus. (8580185)
1995
42
Heparin-induced thrombocytopenia and thrombosis. (9372019)
1995
43
A case of common variable immunodeficiency associated with cyclic thrombocytopenia. (7871984)
1994
44
Dengue virus and endothelial cell: a related phenomenon to thrombocytopenia and granulocytopenia in dengue hemorrhagic fever. (7886587)
1993
45
The effect of a single course of alpha-2B-interferon in patients with HIV-related and chronic idiopathic immune thrombocytopenia. (8329555)
1993
46
Characterization of an antibody to the integrin beta 3 subunit (GP IIIa) from a patient with neonatal thrombocytopenia and an inherited deficiency of GP IIb-IIIa complexes in platelets (Glanzmann's thrombasthenia). (1633270)
1992
47
Plasma levels of endothelial-derived haemostatic factors in autoimmune thrombocytopenia and haemolytic anaemia. (2119418)
1990
48
Splenectomy for thrombocytopenia due to secondary hypersplenism. (3422554)
1988
49
Quinidine leukopenia and thrombocytopenia with a drug-dependent leukoagglutinin. (836544)
1977
50
Congenital lipomatosis of the pancreas. Malabsorption, dwarfism, leukopenia with relative granulocytopenia and thrombocytopenia. (5665293)
1968

Variations for Thrombocytopenia

About this section

Expression for genes affiliated with Thrombocytopenia

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Thrombocytopenia

Search GEO for disease gene expression data for Thrombocytopenia.

Pathways for genes affiliated with Thrombocytopenia

About this section
Sources:
50PathCards, 54R&D Systems, 55Reactome, 5Cell Signaling Technology, 60Thomson Reuters, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 51PharmGKB
See all sources

Pathways related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ITGA2, ITGA2B
29.7GP1BA, ITGA2
3
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.6MPL, THPO
49.4CYCS, ITGA2B, ITGA2
5
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.4ITGA2, ITGB3, WAS
69.3ITGA2B, ITGB3
79.3ITGA2B, ITGB3
89.3ITGA2B, ITGB3
99.0ITGB3, ITGA2B, ITGA2
10
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.0ITGA2, ITGA2B, ITGB3
119.0ITGA2, ITGA2B, ITGB3
129.0ITGA2, ITGA2B, ITGB3
139.0ITGB3, ITGA2B, ITGA2
14
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.0ITGB3, ITGA2B, ITGA2
159.0ITGA2, ITGA2B, ITGB3
16
Show member pathways
8.8WAS, ITGB3, ITGA2B, ITGA2
17
Show member pathways
8.8ITGA2, ITGA2B, ITGB3, WAS
18
Show member pathways
8.8ITGA2, ITGA2B, ITGB3, WAS
19
Show member pathways
8.8ITGA2, ITGA2B, ITGB3, WAS
20
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.5GP1BA, ITGB3, ITGA2B, ITGA2
21
Show member pathways
8.5CYCS, ITGB3, ITGA2B, ITGA2, GATA1
228.2ITGB3, ITGA2B, ITGA2, IL3
23
Show member pathways
7.9THPO, GP1BA, MPL, ITGB3, ITGA2B
24
Show member pathways
7.8THPO, ITGB3, ITGA2B, ITGA2, IL3
25
Show member pathways
7.8IL3, ITGA2, ITGA2B, ITGB3, THPO
26
Show member pathways
7.6THPO, WAS, ITGB3, ITGA2B, ITGA2, IL3
27
Show member pathways
7.5THPO, CYCS, ITGB3, ITGA2B, ITGA2, IL3
28
Show member pathways
7.5THPO, CYCS, ITGB3, ITGA2B, ITGA2, IL3
29
Show member pathways
7.4THPO, GP1BA, MPL, ITGB3, ITGA2B, ITGA2
30
Show member pathways
7.4THPO, MPL, ITGB3, ITGA2B, ITGA2, IL3
317.3IL3, ITGA2, ITGA2B, ITGB3, GP1BA, THPO

Compounds for genes affiliated with Thrombocytopenia

About this section
Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 24HMDB, 29IUPHAR
See all sources

Compounds related to Thrombocytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1megapoietin4510.0MPL, THPO
2anagrelide45 1111.0THPO, MPL
3aebsf459.9CFI, CYCS
4convulxin459.9ITGA2, GP1BA
5aclarubicin459.7IL3, GATA1
6obtustatin619.7ITGB3, ITGA2B
7a 286982619.7ITGB3, ITGA2B
8bio 1211619.7ITGB3, ITGA2B
9leukadherin 1619.7ITGB3, ITGA2B
10tc-i 15619.7ITGB3, ITGA2B
11homoharringtonine45 51 1111.7CYCS, IL3
12mafosfamide459.6THPO, IL3
13pixy321459.6IL3, THPO
14thromboxane45 2410.5THPO, MPL, ITGA2, GATA1
15amifostine45 1110.5IL3, THPO
16tirofiban45 1110.5ITGA2, ITGA2B, ITGB3
17latex459.5THPO, GP1BA, WAS, ITGA2
18filgrastim45 1110.4IL3, THPO
19hydroxyurea45 51 1111.4GATA1, IL3, THPO
20cytarabine45 51 1111.3THPO, IL3, GATA1
21abciximab45 1110.2GP1BA, ITGB3, ITGA2B
22ristocetin459.2GP1BA, ITGB3
23gp 130459.1IL3, MPL, THPO
24proline459.1GP1BA, WAS, ITGB3, ITGA2
25phosphatidylcholine459.1IL3, ITGA2, CYCS
26actinomycin d459.1THPO, CYCS, IL3, GATA1
27iron45 2410.0THPO, MPL, ITGB3, GATA1
2812-o-tetradecanoylphorbol 13-acetate459.0ITGA2B, ITGA2, IL3, GATA1
29butyrate458.9THPO, CYCS, ITGA2, IL3, GATA1
30vegf458.8THPO, MPL, ITGB3, ITGA2, GATA1
31cycloheximide458.8GATA1, IL3, ITGA2, CYCS
32prostacyclin458.8THPO, GP1BA, IL3
33phosphatidylserine45 29 1110.7ITGB3, GP1BA, CYCS
34atp45 299.7THPO, CYCS, WAS, ITGB3, ITGA2, RBM8A
35lactate458.6THPO, CYCS, GP1BA, IL3
36aspirin45 51 29 2411.6THPO, GP1BA, MPL, ITGB3, ITGA2
37lysine458.6THPO, MPL, ITGB3, ITGA2B, ITGA2
38heparin45 29 24 1111.5THPO, CFI, GP1BA, ITGA2, IL3
39retinoic acid45 249.5THPO, CYCS, CFI, ITGA2, IL3, GATA1
40glucose458.4THPO, CFI, GP1BA, ITGB3, ITGA2
41estrogen458.2THPO, CFI, ITGB3, IL3, GATA1
42fibrinogen458.2THPO, CFI, GP1BA, ITGB3, ITGA2B, ITGA2
43phosphatidylinositol458.2IL3, ITGA2, WAS, MPL, GP1BA, THPO
44threonine458.1GP1BA, MPL, ITGB3, ITGA2, IL3
45calcium45 51 24 1110.8THPO, CFI, GP1BA, WAS, ITGB3, ITGA2B
46alanine457.8HOXA11, THPO, GP1BA, MPL, ITGB3, IL3
47adp45 29 249.6MASTL, THPO, GP1BA, MPL, WAS, ITGB3
48tyrosine457.5THPO, GP1BA, MPL, WAS, ITGB3, ITGA2
49cysteine457.5THPO, CYCS, MPL, ITGB3, ITGA2B, ITGA2
50serine456.8CYCS, CFI, GP1BA, MPL, WAS, ITGB3

GO Terms for genes affiliated with Thrombocytopenia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1focal adhesionGO:0059259.0ITGA2, ITGA2B, ITGB3
2platelet alpha granule membraneGO:0310929.0ITGA2B, ITGB3
3integrin complexGO:0083059.0ITGA2, ITGA2B, ITGB3

Biological processes related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of leukocyte migrationGO:0026879.6ITGA2B, ITGA2
2embryonic hemopoiesisGO:0351629.4GATA1, IL3
3platelet aggregationGO:0705279.2GATA1, ITGA2B, ITGB3
4integrin-mediated signaling pathwayGO:0072299.1ITGB3, ITGA2B, ITGA2
5cell-matrix adhesionGO:0071609.1ITGA2, ITGA2B, ITGB3
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.9ITGB3, IL3, GATA1
7cell adhesionGO:0071558.2ITGA2, ITGA2B, ITGB3, GP1BA
8platelet activationGO:0301688.1THPO, GP1BA, MPL, ITGB3, ITGA2B
9blood coagulationGO:0075967.4GATA1, THPO, GP1BA, MPL, WAS, ITGB3

Products for genes affiliated with Thrombocytopenia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thrombocytopenia

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet