MCID: THR014
MIFTS: 66

Thrombocytopenia malady

Blood category

Summaries for Thrombocytopenia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 The terms thrombocytopenia and thrombopenia refer to a relative decrease of platelets in blood. more...

MalaCards: Thrombocytopenia, also known as platelet count below reference range, is related to congenital amegakaryocytic thrombocytopenia and thrombocytopenia-absent radius syndrome. An important gene associated with Thrombocytopenia is WAS (Wiskott-Aldrich syndrome), and among its related pathways are Hematopoietic cell lineage and Akt Signaling. The drugs desmopressin and interferon alfa-2a and the compounds tyrosine and fibrinogen have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Aliases & Classifications for Thrombocytopenia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

thrombocytopenia 8 10 45 31 61
platelet count below reference range 8


External Ids:

Disease Ontology8 DOID:1588
MeSH35 D013921
ICD9CM27 287.5
NCIt40 C3408

Related Diseases for Thrombocytopenia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the thrombocytopenia 2 family:

thrombocytopenia due to platelet alloimmunization acquired thrombocytopenia
thrombocytopenia thrombocytopenia with elevated serum iga and renal disease
thrombocytopenia 4 thrombocytopenia with beta-thalassemia, x-linked

Diseases related to Thrombocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 503)
idRelated DiseaseScoreTop Affiliating Genes
1congenital amegakaryocytic thrombocytopenia30.9IL3, MPL, THPO
2thrombocytopenia-absent radius syndrome30.9THPO
3wiskott-aldrich syndrome30.8WAS, THPO, GATA1
4x-linked thrombocytopenia30.7ZFPM1, GATA1, WAS, THPO
5acquired thrombocytopenia30.7THPO, IL11
6hepatitis c30.6THPO, CYCS
7thrombocytopenia 230.6MASTL, THC2
8acute leukemia30.5IL3, MPL, GATA1, THPO, IL11
9autoimmune thrombocytopenic purpura30.5MPL, THPO, ITGB3
10splenomegaly30.5THPO, MPL
11hypersplenism30.5THPO
12thrombocytosis30.4GP1BA, IL3, IL11, THPO, MPL
13thrombocytopenia due to platelet alloimmunization30.4THPO, MPL, GP5
14thromboembolism30.3ITGA2
15myelodysplastic syndromes30.2MPL, IL3, IL11, GP1BA, THPO, GATA1
16gray platelet syndrome30.2GP5, GATA1
17acute myocardial infarction30.2CYCS
18bernard-soulier syndrome30.1ITGB3, GP5, GP1BA, ITGA2, THPO
19aplastic anemia30.0GATA1, MPL, IL3, GP1BA, THPO, IL11
20polycythemia vera30.0IL3, THPO, ITGB3, MPL
21pancytopenia30.0MPL, IL3, THPO
22thalassemia30.0GATA1
23coronary thrombosis30.0ITGB3
24arthritis30.0CYCS
25deficiency anemia29.9GATA1, MPL, THPO, IL11, IL3
26splenic sequestration29.9THPO
27myeloproliferative disorder29.8MPL, IL11, THPO, ITGB3, GATA1, IL3
28chronic myeloid leukemia29.8THPO, ITGB3, GATA1, IL3, MPL, IL11
29refractory anemia29.8IL11, IL3, THPO, MPL
30acute lymphocytic leukemia29.8MPL, GATA1, THPO, IL3
31glanzmann's thrombasthenia29.8ITGB3
32down syndrome29.8ITGA2, GATA1
33blood platelet disease29.6GP1BA, GP5, THPO
34cadasil29.6CYCS, ITGB3, ITGA2, GP1BA
35adenocarcinoma29.6ITGA2
36heparin-induced thrombocytopenia11.2
37leukopenia10.6
38cyclic thrombocytopenia10.5
39n syndrome10.5
40thrombocytopenia, neonatal alloimmune10.5
41systemic lupus erythematosus10.4
42hepatitis a10.4
43hemangioma thrombocytopenia syndrome10.4
44hemorrhagic fever10.4
45autoimmune hemolytic anemia10.3
46myh9 related thrombocytopenia10.3
47dengue hemorrhagic fever10.3
48antiphospholipid syndrome10.3
49plasmodium vivax malaria10.3
50paris-trousseau thrombocytopenia10.3

Graphical network of the top 20 diseases related to Thrombocytopenia:



Diseases related to thrombocytopenia

Clinical Features for Thrombocytopenia

Drugs & Therapeutics for Thrombocytopenia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Thrombocytopenia

Drug clinical trials:

Search ClinicalTrials for Thrombocytopenia

Search NIH Clinical Center for Thrombocytopenia

Search CenterWatch for Thrombocytopenia

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Thrombocytopenia cell therapies at LifeMap Discovery.

Genetic Tests for Thrombocytopenia

Anatomical Context for Thrombocytopenia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Thrombocytopenia:

33
Skin, Ovary, Liver, Kidney, Lung, Spleen, Bone marrow, Whole blood, Heart, Skeletal muscle, Small intestine, Colon, Pancreas, Thyroid, Breast, Placenta, Prostate, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal liver, Fetal lung, Fetal thyroid, Pineal, Pituitary

Animal Models for Thrombocytopenia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Thrombocytopenia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.3THPO, WAS, GATA1, ITGB3, ITGA2, MPL
2MP:000537611.2WAS, GATA1, ITGB3, ITGA2, MPL, ANKRD26
3MP:000538410.8WAS, GATA1, MPL, CYCS, HOXA11, IL3
4MP:000536710.8CFI, ANKRD26, ITGB3, WAS

Publications for Thrombocytopenia

Sources:
51PubMed
See all sources

Articles related to Thrombocytopenia:

(show top 50)    (show all 2160)
idTitleAuthorsYear
1
Preoperative thrombocytopenia and postoperative outcomes after noncardiac surgery. (23903021)
2014
2
The frequency of heparin-induced thrombocytopenia in Taiwanese patients undergoing cardiopulmonary bypass surgery. (24331583)
2013
3
Progressive bruising in an otherwise healthy child: immune thrombocytopenia purpura. (23673199)
2013
4
Heparin-induced thrombocytopenia. (23546723)
2013
5
Evidence-based focused review of platelet transfusions for critically ill patients with thrombocytopenia. (24335233)
2013
6
Nonheparin anticoagulants for heparin-induced thrombocytopenia. (23758251)
2013
7
Thrombocytopenia in Plasmodium vivax malaria is related to platelets phagocytosis. (23723981)
2013
8
Genetic variability in platelet integrin I+2I^1 density: possible contributor to Plasmodium vivax-induced severe thrombocytopenia. (23249684)
2013
9
Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group. (23361904)
2013
10
Meningococcemia and heparin-induced thrombocytopenia: a dangerous combination. (23061921)
2013
11
Rapidly Involuting Congenital Hemangioma Associated with Profound, Transient Thrombocytopenia. (22937785)
2012
12
CD72 gene expression in immune thrombocytopenia. (22111667)
2012
13
Resolution of thrombocytopenia secondary to disseminated intravascular coagulation with docetaxel chemotherapy in prostate cancer. (20535002)
2012
14
Current and emerging therapeutics for heparin-induced thrombocytopenia. (22314601)
2012
15
Comparison of bivalirudin dosing strategies using total, adjusted, and ideal body weights in obese patients with heparin-induced thrombocytopenia. (22392825)
2012
16
A rare and undesirable complication of heparin-induced thrombocytopenia: acute massive pulmonary embolism. (20699250)
2011
17
HIV-1 Tat-induced platelet activation and release of CD154 contribute to HIV-1-associated autoimmune thrombocytopenia. (21143381)
2011
18
Heparin-induced thrombocytopenia and warfarin-induced skin necrosis: case report. (21308322)
2010
19
Eltrombopag (Promacta), a thrombopoietin receptor agonist for the treatment of thrombocytopenia: current and future considerations. (19451811)
2010
20
Can we prevent blood dyscrasia (leucopenia, thrombocytopenia) and epileptic seizures induced by clozapine. (20305597)
2010
21
Pancytopenia with severe thrombocytopenia in a patient treated with twice-weekly LDL-apheresis by polyacrylate adsorption from whole blood. (20101676)
2010
22
Laboratory methods and management of patients with heparin-induced thrombocytopenia. (20617416)
2010
23
Reducing harm associated with anticoagulation: practical considerations of argatroban therapy in heparin-induced thrombocytopenia. (19338378)
2009
24
Pathobiology of secondary immune thrombocytopenia. (19245930)
2009
25
Heparin-induced thrombocytopenia successfully treated with fondaparinux. (19432027)
2009
26
Heparin-induced thrombocytopenia: your questions answered. (19174629)
2009
27
In vivo inactivation of MASTL kinase results in thrombocytopenia. (19460416)
2009
28
Rituximab-associated acute thrombocytopenia: an under-diagnosed phenomenon. (19260124)
2009
29
Improvement of pancytopenia and thrombocytopenia with decreasing mosaicism for isochromosome Xp. (19145639)
2009
30
Thrombocytopenia with absent radii (TAR) syndrome: from hemopoietic progenitor to mesenchymal stromal cell disease? (19028006)
2009
31
Monitoring and management of heparin-induced thrombocytopenia. (20081589)
2009
32
Efalizumab-induced severe thrombocytopenia can be resolved. (19707471)
2008
33
A prospective study of maternal anti-HPA 1a antibody level as a potential predictor of alloimmune thrombocytopenia in the newborn. (18443267)
2008
34
Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit. (17464135)
2007
35
Significance of detecting platelet associated antibody and platelet membrane glycoprotein for diagnosis of immune thrombocytopenia]. (15157339)
2004
36
Excessive anticoagulation and anaphylactic reaction after rechallenge with lepirudin in a patient with heparin-induced thrombocytopenia. (15585446)
2004
37
Effects of recombinant human interleukin 11 on thrombocytopenia and neutropenia in irradiated rhesus monkeys. (15387143)
2004
38
Anti-c-Mpl (thrombopoietin receptor) autoantibody-induced amegakaryocytic thrombocytopenia in a patient with systemic sclerosis. (12794833)
2003
39
Successful treatment of a patient with hairy cell leukemia and pentostatin-induced autoimmune thrombocytopenia with rituximab. (12701118)
2003
40
Thrombocytopenia during the course of acute poststreptococcal glomerulonephritis. (12921303)
2003
41
Is the thrombopoietin assay useful for differential diagnosis of thrombocytopenia? Analysis of a cohort of 160 patients with thrombocytopenia and defined platelet life span. (11514400)
2001
42
Radiology case of the month. Congenital limb and bleeding disorder. Thrombocytopenia absent radius syndrome (TAR). (11125506)
2000
43
An autosomal dominant thrombocytopenia gene maps to chromosomal region 10p. (10521306)
1999
44
Immunoblastic lymphadenopathy-like T cell lymphoma with high levels of serum interleukin-6, cold agglutinin disease, and immune thrombocytopenia]. (9866423)
1998
45
Coagulation studies in patients with marked thrombocytopenia due to severe preeclampsia. (7612100)
1995
46
Effect of a factor VIII concentrate on type IIB von Willebrand's disease-associated thrombocytopenia presenting during pregnancy in identical twin mothers. (2117853)
1990
47
Levamisole induced granulocytopenia and thrombocytopenia in a case of Crohn's colitis. (437394)
1979
48
(51Cr)platelet kinetics in thrombocytopenia. Correlation between splenic sequestration of platelets and response to splenectomy. (4524870)
1974
49
Congenital lipomatosis of the pancreas. Malabsorption, dwarfism, leukopenia with relative granulocytopenia and thrombocytopenia. (5665293)
1968
50
Replacement transfusion therapy of thrombocytopenia and leukopenia. (5856194)
1964

Genetic Variations for Thrombocytopenia

Expression for genes affiliated with Thrombocytopenia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Thrombocytopenia

Search GEO for disease gene expression data for Thrombocytopenia.

Pathways for genes affiliated with Thrombocytopenia

Sources:
30KEGG, 52QIAGEN, 54Reactome, 50PharmGKB
See all sources

Pathways related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0THPO, ITGB3, ITGA2, IL3, IL11, GP1BA
2
Hide members
10.9WAS, ITGB3, ITGA2, IL3, IL11, THPO
3
Hide members
10.9ITGB3, ITGA2, CYCS, IL3, IL11, THPO
4
Hide members
10.9ITGB3, ITGA2, MPL, IL3, IL11, THPO
5
Hide members
10.9ITGB3, ITGA2, CYCS, IL3, THPO
6
Hide members
10.9THPO, GP5, GP1BA, MPL, ITGB3
7
Hide members
10.8MPL, ITGA2, ITGB3, GATA1
8
Hide members
10.8ITGB3, ITGA2, GP1BA, GP5
9
Hide members
10.8THPO, GP5, GP1BA, ZFPM1
1010.7ITGA2, GP1BA, GP5
1110.7ITGB3, ITGA2, GP5
1210.6GP5, GP1BA

Compounds for genes affiliated with Thrombocytopenia

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Thrombocytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.5WAS, ITGB3, ITGA2, MPL, IL3, IL11
2fibrinogen4511.5THPO, ITGB3, ITGA2, IL11, GP1BA, GP5
3phosphatidylinositol4511.5WAS, ITGA2, MPL, IL3, IL11, GP1BA
4alanine4511.4ITGB3, MPL, HOXA11, IL3, IL11, GP1BA
5retinoic acid45 2412.4GATA1, ITGA2, CYCS, IL3, IL11, CFI
6cysteine4511.4ITGB3, ITGA2, MPL, CYCS, IL3, IL11
7butyrate4511.4GATA1, ITGA2, CYCS, IL3, IL11, THPO
8aspirin45 50 29 2414.4ITGB3, ITGA2, MPL, GP1BA, GP5, THPO
9serine4511.3WAS, GATA1, MPL, CYCS, GP1BA
10threonine4511.3ITGB3, ITGA2, MPL, IL3, IL11, GP1BA
11heparin45 29 11 2414.3ITGA2, IL11, GP1BA, CFI, THPO
12iron45 2412.3THPO, IL11, MPL, ITGB3, GATA1
13lactate4511.2CYCS, IL3, GP1BA, GP5, THPO
14thromboxane45 2412.2THPO, MPL, ITGA2, GATA1
15estrogen4511.2GATA1, ITGB3, IL3, IL11, CFI, THPO
16adp45 29 2413.2MASTL, MPL, ITGA2, WAS
17latex4511.2WAS, ITGA2, GP1BA, THPO
18gp 1304511.2MPL, IL3, IL11, THPO
19cytarabine45 50 1113.2GATA1, IL3, IL11, THPO
20cycloheximide4511.2GATA1, ITGA2, CYCS, IL3, IL11
21atp45 2912.2WAS, RBM8A, ITGB3, ITGA2, CYCS, THPO
22pixy3214511.2IL3, IL11, THPO
23amifostine45 1112.1IL3, IL11, THPO
245fluorouracil4511.1THPO, IL11, IL3, MPL
25filgrastim45 1112.1THPO, IL11, IL3
26polyacrylamide4511.1ITGB3, ITGA2, IL11, CFI
27glucose4511.1ITGB3, ITGA2, IL11, GP1BA, CFI, THPO
28epinephrine45 11 2413.1ITGA2, IL11, GP1BA, THPO
29etoposide45 50 60 1114.1THPO, IL11, IL3, CYCS
30gm-csf45 2912.1THPO, IL11, IL3
31ifosfamide45 1112.1THPO, IL11, IL3
32methylcellulose4511.1IL3, IL11, THPO
33vegf4511.1GATA1, MPL, THPO
3412-o-tetradecanoylphorbol 13-acetate4511.1IL11, IL3, ITGA2, GATA1
35megapoietin4511.0THPO, MPL
36carboplatin45 50 1113.0IL3, IL11, THPO
37il 114511.0IL11, IL3
38vitamin d4511.0GATA1, ITGB3, IL3, IL11
39mafosfamide4511.0THPO, IL3
40anagrelide45 1111.9THPO, MPL
41polyethylene glycol4510.9THPO, IL11, MPL
42homoharringtonine45 1111.9CYCS, IL3
43aclarubicin4510.9GATA1, IL3
44paclitaxel45 50 1112.9IL11, IL3, CYCS
45hydroxyurea45 50 1112.8GATA1, IL3, THPO
46actinomycin d4510.8THPO, IL3, CYCS, GATA1
47convulxin4510.7GP1BA, ITGA2
48wortmannin4510.7WAS, IL3, IL11, THPO
49idarubicin45 50 1112.6IL3, IL11
50doxorubicin45 50 1112.5GATA1, CYCS, IL3, IL11

GO Terms for genes affiliated with Thrombocytopenia

Sources:
16Gene Ontology
See all sources

Biological processes related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.4THPO, WAS, GATA1, ITGB3, ITGA2, MPL
2platelet activationGO:03016811.2ITGB3, MPL, IL11, GP1BA, GP5, THPO
3positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.0GATA1, ITGB3, IL3, IL11
4megakaryocyte differentiationGO:03021910.9ZFPM1, IL11, GATA1
5embryonic hemopoiesisGO:03516210.9ZFPM1, IL3, GATA1
6transcriptional activation by promoter-enhancer loopingGO:07173310.8ZFPM1, GATA1
7regulation of chemokine productionGO:03264210.7MPL, ZFPM1
8cell-matrix adhesionGO:00716010.7GP5, ITGA2, ITGB3
9regulation of definitive erythrocyte differentiationGO:01072410.7GATA1, ZFPM1
10blood coagulation, intrinsic pathwayGO:00759710.6GP5, GP1BA
11platelet formationGO:03022010.5GATA1, ZFPM1
12platelet aggregationGO:07052710.3ITGB3, GATA1

Products for genes affiliated with Thrombocytopenia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thrombocytopenia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet