MCID: THR014
MIFTS: 69

Thrombocytopenia malady

Genetic diseases, Blood diseases, Rare diseases, Immune diseases categories

Summaries for Thrombocytopenia

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Wikipedia:65 The terms thrombocytopenia and thrombopenia refer to a disorder in which there is a relative decrease of... more...

MalaCards based summary: Thrombocytopenia is related to thrombocytopenia-absent radius syndrome and purpura. An important gene associated with Thrombocytopenia is WAS (Wiskott-Aldrich syndrome), and among its related pathways are Articular Cartilage Extracellular Matrix and Platelet Adhesion to exposed collagen. The drugs desmopressin and interferon alfa-2a and the compounds megapoietin and anagrelide have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related mouse phenotypes are embryogenesis and renal/urinary system.

Disease Ontology:10 A blood platelet disease characterized by low a platelet count in the blood.

Aliases & Classifications for Thrombocytopenia

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Thrombocytopenia, Aliases & Descriptions:

Name: Thrombocytopenia 32 10 12 45 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


External Ids:

Disease Ontology10 DOID:1588
ICD9CM29 287.5
NCIt40 C3408
MeSH35 D013921

Related Diseases for Thrombocytopenia

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Diseases in the Thrombocytopenia family:

Thrombocytopenia 4 Thrombocytopenia 2
Thrombocytopenia 5 Thrombocytopenia Due to Platelet Alloimmunization
Acquired Thrombocytopenia Myh9 Related Thrombocytopenia
Mastl-Related Thrombocytopenia 2 Ankrd26-Related Thrombocytopenia 2
Gata1-Related Thrombocytopenia

Diseases related to Thrombocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 656)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia-absent radius syndrome31.1THPO
2purpura30.9THPO
3wiskott-aldrich syndrome30.9GATA1, WAS, THPO
4thrombocytopenia, x-linked30.8WAS, THPO, GATA1
5thrombocytopenia, congenital amegakaryocytic30.7IL3, MPL, THPO
6leukemia30.6GATA1, MPL, ITGB3, ITGA2B, IL3, HOXA11
7splenomegaly30.5THPO, MPL
8neutropenia30.5WAS, IL3, MPL, THPO
9von willebrand's disease30.4GP1BA, ITGA2B
10thrombocytopenia due to platelet alloimmunization30.4ITGA2B, MPL, THPO
11thrombocytosis30.4THPO, GP1BA, MPL, IL3
12gray platelet syndrome30.4GATA1
13thrombocytopenia 230.3ANKRD26
14myelodysplastic syndrome30.3GATA1, IL3, MPL, THPO, GP1BA
15myelofibrosis30.3MPL, THPO
16thrombocytopenic purpura, autoimmune30.3GP1BA, MPL, THPO, ITGB3
17myeloid leukemia30.2THPO, GATA1, IL3, MPL, CFI, CYCS
18myocardial infarction30.2ITGB3, GP1BA, CYCS, ITGA2B, ITGA2
19liver cirrhosis30.1ITGB3, THPO, MPL
20deficiency anemia30.1MPL, IL3, THPO, GATA1
21polycythemia vera30.1IL3, ITGB3, MPL, THPO
22pancytopenia30.0THPO, MPL, IL3
23breast cancer30.0GATA1, ITGA2, GP1BA, CYCS
24acute leukemia30.0THPO, GATA1, MPL, IL3
25coronary thrombosis30.0ITGB3
26polycythemia30.0MPL, ITGB3, IL3, THPO
27aplastic anemia30.0IL3, THPO, MPL, GP1BA, GATA1
28bernard-soulier syndrome, type c29.9ITGA2, ITGA2B, ITGB3, GP1BA, THPO
29rheumatoid arthritis29.9THPO, CFI, ITGA2, ITGB3
30essential thrombocythemia29.8GATA1, IL3, MPL, THPO
31glanzmann thrombasthenia29.6ITGB3, ITGA2B
32severe congenital neutropenia29.6THPO, IL3
33vascular disease29.6ITGA2, ITGB3, GP1BA
34heparin-induced thrombocytopenia11.2
35leukopenia10.6
36hepatitis10.6
37cyclic thrombocytopenia10.6
38hemolytic anemia10.5
39malaria10.5
40hepatitis c10.5
41hemangioma10.4
42hemangioma thrombocytopenia syndrome10.4
43systemic lupus erythematosus10.4
44lupus erythematosus10.4
45acquired thrombocytopenia10.4
46hypersplenism10.4
47dyserythropoietic anemia and thrombocytopenia10.4
48plasmodium vivax malaria10.4
49autoimmune hemolytic anemia10.4
50hemorrhagic fever10.4

Graphical network of the top 20 diseases related to Thrombocytopenia:



Diseases related to thrombocytopenia

Symptoms for Thrombocytopenia

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Drugs & Therapeutics for Thrombocytopenia

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Genetic Tests for Thrombocytopenia

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Anatomical Context for Thrombocytopenia

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MalaCards organs/tissues related to Thrombocytopenia:

33
Liver, Bone, Testes, Bone marrow, T cells, Heart, Spleen, Skin, Myeloid, B cells, Kidney, Lung, Monocytes, Breast, Endothelial, Pituitary, Thyroid, Whole blood, Colon, Pancreas, Neutrophil, Lymph node, Ovary, Placenta, Prostate, Pineal

Animal Models for Thrombocytopenia or affiliated genes

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MGI Mouse Phenotypes related to Thrombocytopenia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.1MPL, ITGB3, ITGA2B, MASTL, GATA1, CYCS
2MP:00053677.8HOXA11, CFI, WAS, ANKRD26, ITGB3, IL3
3MP:00053876.6THPO, CYCS, MPL, WAS, ITGB3, ITGA2B
4MP:00053766.2WAS, MPL, GP1BA, CFI, ANKRD26, ITGB3
5MP:00053976.1MPL, GP1BA, CYCS, THPO, WAS, ITGB3
6MP:00053846.1GATA1, HOXA11, CYCS, GP1BA, MPL, WAS

Publications for Thrombocytopenia

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Articles related to Thrombocytopenia:

(show top 50)    (show all 2263)
idTitleAuthorsYear
1
Vitamin B12 and vitamin d deficiencies: an unusual cause of Fever, severe hemolytic anemia and thrombocytopenia. (25811010)
2015
2
Heparin-induced thrombocytopenia. (25751293)
2015
3
Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia. (24438083)
2014
4
Dental procedures in 24 patients with chronic immune thrombocytopenia in prospective clinical studies of eltrombopag. (24433306)
2014
5
Therapeutic platelet transfusion for hypoproliferative thrombocytopenia - authors' reply. (23472916)
2013
6
Heparin-induced thrombocytopenia associated with thrombotic microangiopathy. (23715106)
2013
7
Argatroban in heparin-induced thrombocytopenia: rationale for use and place in therapy. (24179672)
2013
8
Oral eltrombopag for up to three years is safe and well-tolerated in Japanese patients with previously treated chronic immune thrombocytopenia: an open-label, extension study. (23896965)
2013
9
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
10
The I+IIb p.Leu841Met (Cab3(a+) ) polymorphism results in a new human platelet alloantigen involved in neonatal alloimmune thrombocytopenia. (22738334)
2013
11
A study of cytological changes in the bone marrow of patients with severe Fever with thrombocytopenia syndrome. (24349423)
2013
12
Rapidly Involuting Congenital Hemangioma Associated with Profound, Transient Thrombocytopenia. (22937785)
2012
13
Thrombocytopenia in HIV-Infected Patients. (23730018)
2012
14
Hemodialysis-associated acute systemic reactions and heparin-induced thrombocytopenia. (22127211)
2012
15
What are the options for anticoagulation needs in dialysis for patients with heparin-induced thrombocytopenia? (21851394)
2011
16
A clinical-laboratory algorithm incorporating optical density value to predict heparin-induced thrombocytopenia. (21264443)
2011
17
Exacerbation of thrombocytopenia in a pregnant woman with thrombocytopenia-absent radius syndrome. (21530967)
2011
18
Novel use of plasmapheresis in a patient with heparin-induced thrombocytopenia requiring urgent insertion of a left ventricular assist device under cardiopulmonary bypass. (20723718)
2010
19
False-positive tests for heparin-induced thrombocytopenia in patients with antiphospholipid syndrome and systemic lupus erythematosus: a rebuttal. (20345710)
2010
20
Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban]. (19795099)
2009
21
Clonal chromosome anomalies and propensity to myeloid malignancies in congenital amegakaryocytic thrombocytopenia (OMIM 604498). (18519517)
2008
22
Serologic results in >1000 patients with suspected heparin-induced thrombocytopenia. (17895512)
2008
23
Successful treatment of autoimmune pancreatitis complicated with autoimmune thrombocytopenia and interstitial pneumonia by prednisolone. (18520116)
2008
24
Spontaneous superior sagittal sinus thrombosis secondary to type II heparin-induced thrombocytopenia presenting as an acute subarachnoid hemorrhage. (17582771)
2007
25
Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit. (17464135)
2007
26
Review article: pharmacological approaches for the treatment of thrombocytopenia in patients with chronic liver disease and hepatitis C infection. (17958517)
2007
27
Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. (16466367)
2006
28
Successful renal transplantation in a patient with heterozygous prothrombin gene, factor V Leiden mutation and heparin-induced thrombocytopenia using r-hirudin as anticoagulant. (16499600)
2006
29
Use of ecarin clotting time in whole blood for monitoring recombinant hirudine treatment during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia]. (15771978)
2005
30
Patterns of thrombocytosis and thrombocytopenia in hospitalized neonates. (15578031)
2005
31
Mayer-Rokitansky-KA1ster-Hauser syndrome associated with thrombocytopenia-absent radius syndrome. (15705390)
2005
32
Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin-induced thrombocytopenia: an analysis of 3 prospective studies. (15280202)
2004
33
Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit. (12477267)
2002
34
Wilson disease manifested primarily as amenorrhea and accompanying thrombocytopenia. (12359384)
2002
35
Treatment of lupus-induced thrombocytopenia with recombinant human interleukin-11. (11212156)
2001
36
Mutations in the thrombopoietin receptor, Mpl, in children with congenital amegakaryocytic thrombocytopenia. (10971406)
2000
37
Sustained response to combination therapy in a patient with chronic hepatitis C and thrombocytopenia secondary to alpha-interferon. (10847447)
2000
38
Further examination of various administration protocols of pegylated recombinant human megakaryocyte growth and development factor on thrombocytopenia in myelosuppressed mice. (10227790)
1998
39
Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production. (8896400)
1996
40
Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia. (8826901)
1996
41
Osteopetrosis, anemia, thrombocytopenia, and marrow necrosis in beef calves naturally infected with bovine virus diarrhea virus. (8580185)
1995
42
Heparin-induced thrombocytopenia and thrombosis. (9372019)
1995
43
A case of common variable immunodeficiency associated with cyclic thrombocytopenia. (7871984)
1994
44
Dengue virus and endothelial cell: a related phenomenon to thrombocytopenia and granulocytopenia in dengue hemorrhagic fever. (7886587)
1993
45
The effect of a single course of alpha-2B-interferon in patients with HIV-related and chronic idiopathic immune thrombocytopenia. (8329555)
1993
46
Characterization of an antibody to the integrin beta 3 subunit (GP IIIa) from a patient with neonatal thrombocytopenia and an inherited deficiency of GP IIb-IIIa complexes in platelets (Glanzmann's thrombasthenia). (1633270)
1992
47
Plasma levels of endothelial-derived haemostatic factors in autoimmune thrombocytopenia and haemolytic anaemia. (2119418)
1990
48
Splenectomy for thrombocytopenia due to secondary hypersplenism. (3422554)
1988
49
Quinidine leukopenia and thrombocytopenia with a drug-dependent leukoagglutinin. (836544)
1977
50
Congenital lipomatosis of the pancreas. Malabsorption, dwarfism, leukopenia with relative granulocytopenia and thrombocytopenia. (5665293)
1968

Variations for Thrombocytopenia

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Expression for genes affiliated with Thrombocytopenia

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Search GEO for disease gene expression data for Thrombocytopenia.

Pathways for genes affiliated with Thrombocytopenia

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Pathways related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ITGA2, ITGA2B
29.7GP1BA, ITGA2
3
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.6MPL, THPO
49.4CYCS, ITGA2B, ITGA2
5
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.4ITGA2, ITGB3, WAS
69.3ITGA2B, ITGB3
79.3ITGA2B, ITGB3
89.3ITGA2B, ITGB3
99.0ITGB3, ITGA2B, ITGA2
10
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.0ITGA2, ITGA2B, ITGB3
119.0ITGA2, ITGA2B, ITGB3
129.0ITGA2, ITGA2B, ITGB3
139.0ITGB3, ITGA2B, ITGA2
14
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.0ITGB3, ITGA2B, ITGA2
159.0ITGA2, ITGA2B, ITGB3
16
Show member pathways
8.8WAS, ITGB3, ITGA2B, ITGA2
17
Show member pathways
8.8ITGA2, ITGA2B, ITGB3, WAS
18
Show member pathways
8.8ITGA2, ITGA2B, ITGB3, WAS
19
Show member pathways
8.8ITGA2, ITGA2B, ITGB3, WAS
20
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.5GP1BA, ITGB3, ITGA2B, ITGA2
21
Show member pathways
8.5CYCS, ITGB3, ITGA2B, ITGA2, GATA1
228.2ITGB3, ITGA2B, ITGA2, IL3
23
Show member pathways
7.9THPO, GP1BA, MPL, ITGB3, ITGA2B
24
Show member pathways
7.8THPO, ITGB3, ITGA2B, ITGA2, IL3
25
Show member pathways
7.8IL3, ITGA2, ITGA2B, ITGB3, THPO
26
Show member pathways
7.6THPO, WAS, ITGB3, ITGA2B, ITGA2, IL3
27
Show member pathways
7.5THPO, CYCS, ITGB3, ITGA2B, ITGA2, IL3
28
Show member pathways
7.5THPO, CYCS, ITGB3, ITGA2B, ITGA2, IL3
29
Show member pathways
7.4THPO, GP1BA, MPL, ITGB3, ITGA2B, ITGA2
30
Show member pathways
7.4THPO, MPL, ITGB3, ITGA2B, ITGA2, IL3
317.3IL3, ITGA2, ITGA2B, ITGB3, GP1BA, THPO

Compounds for genes affiliated with Thrombocytopenia

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Compounds related to Thrombocytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1megapoietin4510.0MPL, THPO
2anagrelide45 1311.0THPO, MPL
3aebsf459.9CFI, CYCS
4convulxin459.9ITGA2, GP1BA
5aclarubicin459.7IL3, GATA1
6obtustatin619.7ITGB3, ITGA2B
7a 286982619.7ITGB3, ITGA2B
8bio 1211619.7ITGB3, ITGA2B
9leukadherin 1619.7ITGB3, ITGA2B
10tc-i 15619.7ITGB3, ITGA2B
11homoharringtonine45 51 1311.7CYCS, IL3
12mafosfamide459.6THPO, IL3
13pixy321459.6IL3, THPO
14thromboxane45 2610.5THPO, MPL, ITGA2, GATA1
15amifostine45 1310.5IL3, THPO
16tirofiban45 1310.5ITGA2, ITGA2B, ITGB3
17latex459.5THPO, GP1BA, WAS, ITGA2
18filgrastim45 1310.4IL3, THPO
19hydroxyurea45 51 1311.4GATA1, IL3, THPO
20cytarabine45 51 1311.3THPO, IL3, GATA1
21abciximab45 1310.2GP1BA, ITGB3, ITGA2B
22ristocetin459.2GP1BA, ITGB3
23gp 130459.1IL3, MPL, THPO
24proline459.1GP1BA, WAS, ITGB3, ITGA2
25phosphatidylcholine459.1IL3, ITGA2, CYCS
26actinomycin d459.1THPO, CYCS, IL3, GATA1
27iron45 2610.0THPO, MPL, ITGB3, GATA1
2812-o-tetradecanoylphorbol 13-acetate459.0ITGA2B, ITGA2, IL3, GATA1
29butyrate458.9THPO, CYCS, ITGA2, IL3, GATA1
30vegf458.8THPO, MPL, ITGB3, ITGA2, GATA1
31cycloheximide458.8GATA1, IL3, ITGA2, CYCS
32prostacyclin458.8THPO, GP1BA, IL3
33phosphatidylserine45 30 1310.7ITGB3, GP1BA, CYCS
34atp45 309.7THPO, CYCS, WAS, ITGB3, ITGA2, RBM8A
35lactate458.6THPO, CYCS, GP1BA, IL3
36aspirin45 51 30 2611.6THPO, GP1BA, MPL, ITGB3, ITGA2
37lysine458.6THPO, MPL, ITGB3, ITGA2B, ITGA2
38heparin45 30 26 1311.5THPO, CFI, GP1BA, ITGA2, IL3
39retinoic acid45 269.5THPO, CYCS, CFI, ITGA2, IL3, GATA1
40glucose458.4THPO, CFI, GP1BA, ITGB3, ITGA2
41estrogen458.2THPO, CFI, ITGB3, IL3, GATA1
42fibrinogen458.2THPO, CFI, GP1BA, ITGB3, ITGA2B, ITGA2
43phosphatidylinositol458.2IL3, ITGA2, WAS, MPL, GP1BA, THPO
44threonine458.1GP1BA, MPL, ITGB3, ITGA2, IL3
45calcium45 51 26 1310.8THPO, CFI, GP1BA, WAS, ITGB3, ITGA2B
46alanine457.8HOXA11, THPO, GP1BA, MPL, ITGB3, IL3
47adp45 30 269.6MASTL, THPO, GP1BA, MPL, WAS, ITGB3
48tyrosine457.5THPO, GP1BA, MPL, WAS, ITGB3, ITGA2
49cysteine457.5THPO, CYCS, MPL, ITGB3, ITGA2B, ITGA2
50serine456.8CYCS, CFI, GP1BA, MPL, WAS, ITGB3

GO Terms for genes affiliated with Thrombocytopenia

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Cellular components related to Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1focal adhesionGO:00059259.0ITGA2, ITGA2B, ITGB3
2platelet alpha granule membraneGO:00310929.0ITGA2B, ITGB3
3integrin complexGO:00083059.0ITGA2, ITGA2B, ITGB3

Biological processes related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of leukocyte migrationGO:00026879.6ITGA2B, ITGA2
2embryonic hemopoiesisGO:00351629.4GATA1, IL3
3platelet aggregationGO:00705279.2GATA1, ITGA2B, ITGB3
4integrin-mediated signaling pathwayGO:00072299.1ITGB3, ITGA2B, ITGA2
5cell-matrix adhesionGO:00071609.1ITGA2, ITGA2B, ITGB3
6positive regulation of peptidyl-tyrosine phosphorylationGO:00507318.9ITGB3, IL3, GATA1
7cell adhesionGO:00071558.2ITGA2, ITGA2B, ITGB3, GP1BA
8platelet activationGO:00301688.1THPO, GP1BA, MPL, ITGB3, ITGA2B
9blood coagulationGO:00075967.4GATA1, THPO, GP1BA, MPL, WAS, ITGB3

Products for genes affiliated with Thrombocytopenia

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Sources for Thrombocytopenia

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet