MCID: THR014
MIFTS: 64

Thrombocytopenia malady

Categories: Blood diseases, Genetic diseases, Rare diseases, Immune diseases

Aliases & Classifications for Thrombocytopenia

Summaries for Thrombocytopenia

Disease Ontology : 12 A blood platelet disease characterized by low a platelet count in the blood.

MalaCards based summary : Thrombocytopenia is related to thrombocytopenia, congenital amegakaryocytic and influenza. An important gene associated with Thrombocytopenia is ETV6 (ETS Variant 6), and among its related pathways/superpathways are Akt Signaling and Response to elevated platelet cytosolic Ca2+. The drugs Carboplatin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and bone, and related phenotypes are cellular and hematopoietic system

Wikipedia : 71 Thrombocytopenia is a disorder characterized by abnormally low levels of thrombocytes, also known as... more...

Related Diseases for Thrombocytopenia

Diseases in the Thrombocytopenia family:

Thrombocytopenia 4 Thrombocytopenia 2
Thrombocytopenia 5 Acquired Thrombocytopenia
Thrombocytopenia Due to Platelet Alloimmunization Primary Thrombocytopenia
Myh9 Related Thrombocytopenia Mastl-Related Thrombocytopenia 2
Gata1-Related Thrombocytopenia Thrombocytopenia 6

Diseases related to Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 616)
id Related Disease Score Top Affiliating Genes
1 thrombocytopenia, congenital amegakaryocytic 33.8 MPL THPO
2 influenza 29.4 F2 F3
3 budd-chiari syndrome 29.3 APOH F2 F3 PF4
4 hemophagocytic lymphohistiocytosis 29.2 CYCS ETV6 MPL THPO
5 essential thrombocythemia 29.1 F2 F3 GP1BA ITGA2B ITGB3
6 myocardial infarction 29.1 ADAMTS13 F2 F3 GP1BA ITGA2 ITGA2B
7 granulomatous hepatitis 29.0 F2 F3 MPL THPO
8 myeloproliferative neoplasm 28.2 ADAMTS13 F2 F3 GP1BA ITGA2B ITGB3
9 thrombocytopenia, x-linked 12.3
10 heparin-induced thrombocytopenia 12.3
11 thrombocytopenia-absent radius syndrome 12.3
12 fetal and neonatal alloimmune thrombocytopenia 12.2
13 thrombocytopenia with beta-thalassemia, x-linked 12.1
14 radioulnar synostosis with amegakaryocytic thrombocytopenia 12.1
15 dyserythropoietic anemia and thrombocytopenia 12.1
16 hemangioma-thrombocytopenia syndrome 12.1
17 thrombocytopenia, x-linked, with or without dyserythropoietic anemia 12.1
18 thrombocytopenia due to platelet alloimmunization 12.0
19 acquired amegakaryocytic thrombocytopenia 12.0
20 thrombocytopenia 5 12.0
21 acquired thrombocytopenia 12.0
22 thrombocytopenia 2 12.0
23 thrombocytopenia 4 12.0
24 thrombocytopenia, paris-trousseau type 11.9
25 primary thrombocytopenia 11.9
26 radioulnar synostosis with amegakaryocytic thrombocytopenia 2 11.9
27 thrombocytopenia 6 11.9
28 thrombocytopenia, neonatal alloimmune 11.9
29 cyclic thrombocytopenia 11.9
30 myh9 related thrombocytopenia 11.9
31 multifocal lymphangioendotheliomatosis with thrombocytopenia 11.8
32 thrombocytopenia robin sequence 11.8
33 transient neonatal thrombocytopenia 11.8
34 autosomal thrombocytopenia with normal platelets 11.7
35 hereditary thrombocytopenia with normal platelets 11.7
36 thrombocytopenia with or without dyserythropoietic anemia 11.7
37 wiskott-aldrich syndrome 11.7
38 gata1-related thrombocytopenia with beta-thalassemia 11.7
39 mastl-related thrombocytopenia 2 11.6
40 gata1-related anemia with thrombocytopenia 11.6
41 autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome 11.6
42 hereditary thrombocytopenia with early-onset myelofibrosis 11.6
43 familial thrombotic thrombocytopenia purpura 11.6
44 skeleto cardiac syndrome with thrombocytopenia 11.6
45 thrombocytopenia cerebellar hypoplasia short stature 11.6
46 thrombocytopenia with elevated serum iga and renal disease 11.6
47 gata1-related thrombocytopenia 11.6
48 evans' syndrome 11.5
49 dk phocomelia syndrome 11.5
50 ivic syndrome 11.5

Graphical network of the top 20 diseases related to Thrombocytopenia:



Diseases related to Thrombocytopenia

Symptoms & Phenotypes for Thrombocytopenia

MGI Mouse Phenotypes related to Thrombocytopenia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 ITGA2B ITGB3 MASTL MPL MYH9 WAS
2 hematopoietic system MP:0005397 10.13 ITGB3 MPL MYH9 PF4 THPO WAS
3 cardiovascular system MP:0005385 10.06 ANKRD26 CYCS ETV6 F2 F3 GATA1
4 homeostasis/metabolism MP:0005376 10.06 ADAMTS13 ANKRD26 APOH ETV6 F2 F3
5 embryo MP:0005380 10.02 CYCS ETV6 F2 F3 GATA1 ITGA2B
6 immune system MP:0005387 9.73 ADAMTS13 CYCS ETV6 F2 F3 GATA1
7 normal MP:0002873 9.23 ADAMTS13 ETV6 F2 F3 GATA1 ITGA2

Drugs & Therapeutics for Thrombocytopenia

Drugs for Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 484)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
2
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
3
Gemcitabine Approved Phase 4,Phase 2,Phase 1 95058-81-4 60750
4
Oprelvekin Approved, Investigational Phase 4,Phase 2,Phase 3 145941-26-0
5 Certoparin Approved Phase 4,Phase 3
6
Dalteparin Approved Phase 4,Phase 3,Phase 2,Phase 1 9041-08-1
7
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
8
Bivalirudin Approved, Investigational Phase 4,Phase 3 128270-60-0 16129704
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
10
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
11
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
12
Idarubicin Approved Phase 4,Phase 3,Phase 2 58957-92-9 42890
13
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
14
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
15
Ribavirin Approved Phase 4,Phase 2,Phase 3 36791-04-5 37542
16
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
17
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
18
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
19
Lansoprazole Approved, Investigational Phase 4,Phase 2 103577-45-3 3883
20
alemtuzumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 216503-57-0
21
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666
22
Fludarabine Approved Phase 4,Phase 3,Phase 1,Phase 2 21679-14-1, 75607-67-9 30751
23
Vidarabine Approved Phase 4,Phase 3,Phase 2 24356-66-9 32326 21704
24
Argatroban Approved, Investigational Phase 4,Phase 3,Phase 2 74863-84-6 152951
25
Abciximab Approved Phase 4,Phase 3 143653-53-6
26 Nadroparin Approved Phase 4 9041-08-1
27
Fluorouracil Approved Phase 4,Phase 3,Phase 2 51-21-8 3385
28
Oxaliplatin Approved, Investigational Phase 4,Phase 2 61825-94-3 5310940 9887054 6857599, 9887054 43805
29
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
30
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
31
Ticlopidine Approved Phase 4 55142-85-3 5472
32
Desirudin Approved Phase 4,Phase 2,Phase 3 120993-53-5
33
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2 198153-51-4 5360545
34
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1 159351-69-6 6442177
35
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53123-88-9 5284616 6436030 46835353
36
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 104987-11-3 445643 439492
37
Dimethyl sulfoxide Approved, Vet_approved Phase 4,Phase 1 67-68-5 679
38
Lepirudin Approved Phase 4 120993-53-5, 138068-37-8 16132441
39
Warfarin Approved Phase 4,Phase 3,Phase 2 81-81-2 6691 54678486
40
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
41
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2 58-05-9 54575, 6560146 143
42
Caffeic acid Experimental Phase 4,Phase 3 331-39-5 1549111
43 Antibodies Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
44 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1
45 calcium heparin Phase 4,Phase 3,Phase 2,Phase 1
46 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
47 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Heparin, Low-Molecular-Weight Phase 4,Phase 3,Phase 2,Phase 1
49 Immunoglobulins Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
50 Antithrombin III Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 759)
id Name Status NCT ID Phase
1 The Study of rHuTPO/rHuIL-11 in the Treatment for Chemotherapy-induced Thrombocytopenia in Patients With NSCLC Unknown status NCT02344979 Phase 4
2 The HIT-TRAP Trial Unknown status NCT00196417 Phase 4
3 Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients Unknown status NCT02355873 Phase 4
4 Comparing Bivalirudin Versus Heparin/ GP IIB/IIA in Patients Undergoing PCI Unknown status NCT00476944 Phase 4
5 Impact of Heparin on the Need for Mechanical Ventilation in Neonates Unknown status NCT00196469 Phase 4
6 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
7 Bivalirudin PCI Registry in Heparin Induced Thrombocytopenia/Heparin Induced Thrombocytopenia and Thrombosis Syndrome (HIT/HITTS) Patients Completed NCT00759083 Phase 4
8 A Study to Confirm the Efficacy and Safety of Fludarabine Phosphate Administered in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia Completed NCT00220311 Phase 4
9 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4
10 Evaluation of Argatroban Injection in Pediatric Patients Requiring Anticoagulant Alternatives to Heparin Completed NCT00039858 Phase 4
11 High-dose Dexamethasone Versus Conventional Dose Prednisone for Initial Treatment of Primary Immune Thrombocytopenia (ITP) Completed NCT01356511 Phase 4
12 Study to Reveal if Fibrinogen Treatment Effects Blood Clotting Better Than a Platelet Transfusion Completed NCT01955811 Phase 4
13 Evaluation of the Efficacy of Platelets Treated With Pathogen Reduction Process Completed NCT01789762 Phase 4
14 EArly Discharge After Transradial Stenting of CoronarY Arteries: The EASY Study Completed NCT00169819 Phase 4
15 Enoxaparin Versus Unfractionated Heparin in PCI Completed NCT00439855 Phase 4
16 Nadroparin for the Initial Treatment of Pulmonary Thromboembolism Completed NCT00796692 Phase 4
17 Value of Abciximab in Patients With AMI Undergoing Primary PCI After Clopidogrel Pretreatment (BRAVE 3) Completed NCT00133250 Phase 4
18 Venous Thromboembolic Prophylaxis After Trauma: Three Times a Day Unfractionated Heparin Versus Twice a Day Enoxaparin Completed NCT01729559 Phase 4
19 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4
20 Study to Evaluate the Mortality Reduction of Enoxaparin in Hospitalized Acutely Ill Medical Receiving Enoxaparin Completed NCT00622648 Phase 4
21 EXCLAIM:Extended Prophylaxis for Venous ThromboEmbolism (VTE) in Acutely Ill Medical Patients With Prolonged Immobilization Completed NCT00077753 Phase 4
22 Intensified Dosing of Cellcept (Mycophenolate Mofetil) in Kidney Transplantation Completed NCT00943228 Phase 4
23 SMD_FLAG-IDA_98: FLAG-IDA in Induction Treatment of High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia Completed NCT00487448 Phase 4
24 Platelet Function in Idiopathic Thrombocytopenic Purpura (ITP) Patients With Eltrombopag Completed NCT00888901 Phase 4
25 Efficacy of Abciximab Bolus Only Regimen in Providing Inhibition of Platelet Action Over Time Completed NCT00929279 Phase 4
26 Safety Study of Stopping Thromboprophylaxis Based on Ultrasound Results After Total Knee Replacement Completed NCT00362492 Phase 4
27 Safety Study of Desirudin, an Anticoagulant for the Prophylaxis of Thrombosis Completed NCT00913133 Phase 4
28 A Study of The Relationship Between Drop in Hemoglobin and Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Copegus (Ribavirin) and Pegasys (Peginterferon Alfa-2a) Completed NCT01585324 Phase 4
29 How Effective Are Antithrombotic Therapies in Primary Percutaneous Coronary Intervention Completed NCT01519518 Phase 4
30 Study Evaluating A Planned Transition From Tacrolimus To Sirolimus In Kidney Transplant Recipients Completed NCT00895583 Phase 4
31 A Safety Study of Intravenous Immunoglobulin in Patients With Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT01390649 Phase 4
32 A Longitudinal 2-year Bone Marrow Study of Eltrombopag in Previously Treated Adults, With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT01098487 Phase 4
33 Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura Completed NCT00467571 Phase 4
34 Protocol for the Infusion of Buffy Coat-derived Cryopreserved Platelets in Patients With Severe Thrombocytopenia Recruiting NCT02032134 Phase 4
35 Efficacy and Safety of rhTPO for the Treatment of Thrombocytopenia After Chemotherapy in AML Patients Recruiting NCT02267993 Phase 4
36 Caffeic Acid Combining High-dose Dexamethasone in Management of ITP Recruiting NCT02556814 Phase 4
37 Immunomodulation With Romiplostim in Young Adults With ITP Recruiting NCT02760251 Phase 4
38 A Rollover Study to Provide Continued Treatment With Eltrombopag Recruiting NCT01957176 Phase 4
39 Rate of Prolonged Response After Stopping Thrombopoietin-receptor Agonists Treatment in ITP Recruiting NCT03119974 Phase 4
40 A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab) Recruiting NCT01734382 Phase 4
41 Efficacy and Safety of rHuTPO on Platelet Engraftment After Allo-HSCT Recruiting NCT01379391 Phase 4
42 Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction Recruiting NCT01935128 Phase 4
43 Study Assessing an Algorithm-based Strategy of Eculizumab Discontinuation in Children and Adults With aHUS Recruiting NCT02574403 Phase 4
44 Thromboprophylaxis of Venous Thromboembolism in Acutely-ill Medical Inpatients With Thrombocytopenia Active, not recruiting NCT01727401 Phase 4
45 Eval. of Potential Predictors of Disease Progression in Patients With aHUS Including Genetics, Biomarkers and Treatment Enrolling by invitation NCT02614898 Phase 4
46 Effects of Helicobacter Pylori Eradication in Children With Chronic Immune Thrombocytopenic Purpura Not yet recruiting NCT03172676 Phase 4
47 Normal Saline Versus Heparinized Solution Flush for Maintaining Patency of Peripheral Venous Catheters in Children Suspended NCT01794767 Phase 4
48 Anti-D for Treating Thrombocytopenia in Adults Infected With Hepatitis C Virus With or Without HIV Co-Infection Terminated NCT00239733 Phase 4
49 A Comparative Sudy Comparing Argatroban® IV vs Desirudin SC for Suspected HIT With or Without Thrombosis Syndrome Terminated NCT00787332 Phase 4
50 Argatroban Versus Lepirudin in Critically Ill Patients Terminated NCT00798525 Phase 4

Search NIH Clinical Center for Thrombocytopenia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Thrombocytopenia cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: thrombocytopenia

Genetic Tests for Thrombocytopenia

Genetic tests related to Thrombocytopenia:

id Genetic test Affiliating Genes
1 Thrombocytopenia 29

Anatomical Context for Thrombocytopenia

MalaCards organs/tissues related to Thrombocytopenia:

39
Liver, Testes, Bone, Bone Marrow, T Cells, Heart, Spleen

Publications for Thrombocytopenia

Articles related to Thrombocytopenia:

(show top 50) (show all 2627)
id Title Authors Year
1
Low dose bivalirudin anticoagulation for lung transplantation with extracorporeal membrane oxygenation in a patient with acute heparin-induced thrombocytopenia. ( 28043990 )
2017
2
A Case-control Study of Risk Sources for Severe Fever with Thrombocytopenia Syndrome in Hubei Province, China. ( 28088586 )
2017
3
Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome. ( 28086978 )
2017
4
Refractory primary immune thrombocytopenia with subsequent del(5q) MDS: complete remission of both after lenalidomide. ( 28052942 )
2017
5
FcI^ receptor expression on splenic macrophages in adult immune thrombocytopenia. ( 28142207 )
2017
6
Bone marrow morphology and disease progression in congenital thrombocytopenia: a detailed clinicopathologic and genetic study of eight cases. ( 28059092 )
2017
7
Novel G6B gene variant causes familial autosomal recessive thrombocytopenia and anemia. ( 27743390 )
2017
8
Babesiosis-associated immune thrombocytopenia. ( 28217703 )
2017
9
Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia. ( 28054583 )
2017
10
Score risk model for predicting severe fever with thrombocytopenia syndrome mortality. ( 28061758 )
2017
11
A Right hepatic lobe resection and thrombocytopenia. ( 28051788 )
2017
12
Paroxysmal Nocturnal Hemoglobinuria in the Differential Diagnosis of Thrombocytopenia. ( 28435653 )
2017
13
A neutralization assay with a severe fever with thrombocytopenia syndrome virus strain that makes plaques in inoculated cells. ( 28082164 )
2017
14
Type 2B von Willebrand Disease: An Unusual Cause of Severe Neonatal Thrombocytopenia. ( 28060120 )
2017
15
From chronic immune thrombocytopenia to severe aplastic anemia: recent insights into the evolution of eltrombopag. ( 28473904 )
2017
16
Neonatal Mice with Necrotizing Enterocolitis-like Injury Develop Thrombocytopenia despite Increased Megakaryopoiesis. ( 28085792 )
2017
17
Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis. ( 28296884 )
2017
18
Maternal HLA genotyping is not useful for predicting severity of fetal and neonatal alloimmune thrombocytopenia. ( 27748520 )
2017
19
Pathogens and Epidemiologic Features of Severe Fever with Thrombocytopenia Syndrome in Hubei Province, China. ( 28089865 )
2017
20
Etiology and complications of thrombocytopenia in hospitalized medical patients. ( 28054307 )
2017
21
Infections in non-splenectomized persistent or chronic primary immune thrombocytopenia adults: risk factors and vaccination effect. ( 28078756 )
2017
22
Erratum: Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia. ( 28240280 )
2017
23
Activated platelet-derived and leukocyte-derived circulating microparticles and the risk of thrombosis in heparin-induced thrombocytopenia: A role for pf4-bearing microparticles? ( 28052584 )
2017
24
Association Between TNF-I+ -308G/A Polymorphism and Risk of Immune Thrombocytopenia: A Meta-Analysis. ( 27960071 )
2017
25
Rapid infusions of human normal immunoglobulin 50g/l are safe and well tolerated in immunodeficiencies and immune thrombocytopenia. ( 28073042 )
2017
26
A Study of Human Killer Cell Immunoglobulin-Like Receptor and Multidrug Resistance Gene Polymorphisms in Children With Immune Thrombocytopenia. ( 25792670 )
2016
27
Isolated thrombocytopenia and liver function abnormalities characterizing an atypical presentation of thrombotic thrombocytopenic purpura. ( 27542956 )
2016
28
Hepatitis B Leading to Megaloblastic Anemia and Catastrophic Peripheral Thrombocytopenia. ( 28043314 )
2016
29
Extreme Elevation of Alkaline Phosphatase in a Pregnancy Complicated by Gestational Diabetes and Infant with Neonatal Alloimmune Thrombocytopenia. ( 27610256 )
2016
30
Optical Coherence Tomography Findings in Early Stent Thrombosis by Heparin-Induced Thrombocytopenia. ( 27818479 )
2016
31
Aggressive Posterior Retinopathy of Prematurity Is Associated with Multiple Infectious Episodes and Thrombocytopenia. ( 27631399 )
2016
32
Platelet Activation Testing for Heparin-Induced Thrombocytopenia Antibodies: A Problem That Needs Fixing? ( 27613972 )
2016
33
Fetal and Neonatal Alloimmune Thrombocytopenia: Management and Outcome of a Large International Retrospective Cohort. ( 27728915 )
2016
34
Rituximab-induced Acute Thrombocytopenia in High Tumor Burden Follicular Lymphoma. ( 27477415 )
2016
35
Platelet Count Trends and Prevalence of Heparin-Induced Thrombocytopenia in a Cohort of Extracorporeal Membrane Oxygenator Patients. ( 27441904 )
2016
36
Heparin-induced thrombocytopenia: research and clinical updates. ( 27913490 )
2016
37
Rivaroxaban for Treatment of Suspected or Confirmed Heparin-Induced Thrombocytopenia Study. ( 27061271 )
2016
38
Overlap of IgG4-related Disease and Primary Biliary Cirrhosis Complicated with Autoimmune Thrombocytopenia. ( 27181554 )
2016
39
Management of Primary Immune Thrombocytopenia With Eltrombopag in a Patient With Recent Acute Coronary Syndrome. ( 27650208 )
2016
40
Clinical course and prognostic factors of childhood immune thrombocytopenia: single center experience of 10 years. ( 27610182 )
2016
41
Rapid and durable response to intravenous immunoglobulin in delayed heparin-induced thrombocytopenia: a case report. ( 27943368 )
2016
42
Massive Pulmonary Embolism in a Patient with Heparin Induced Thrombocytopenia: Successful Treatment with Dabigatran. ( 27026768 )
2016
43
Negative Heparin-Induced Thrombocytopenia Test Result After Massive Transfusion: Believe It or Not? ( 27124942 )
2016
44
Efficacy and Safety of Fondaparinux in Patients With Suspected Heparin-Induced Thrombocytopenia. ( 27179015 )
2016
45
Role of ITPA gene polymorphism in ribavirin-induced anemia and thrombocytopenia in Egyptian patients with chronic hepatitis C. ( 26880169 )
2016
46
Anti-Human Platelet Antigen-1a Immunoglobulin G Preparation Intended to Prevent Fetal and Neonatal Alloimmune Thrombocytopenia. ( 27627660 )
2016
47
Severe Fever with Thrombocytopenia Syndrome Virus antibody investigation among domestic bovine transported to slaughterhouse in Shimane Prefecture, Japan. ( 27169939 )
2016
48
Chikungunya Fever With Seizures, Myocarditis, and Severe Thrombocytopenia in a Child With Osteosarcoma. ( 27128980 )
2016
49
High-dose dexamethasone or oral prednisone for immune thrombocytopenia? ( 27658979 )
2016
50
Interleukin-23R gene polymorphism in pediatric Egyptian patients with primary immune thrombocytopenia. ( 26859125 )
2016

Variations for Thrombocytopenia

ClinVar genetic disease variations for Thrombocytopenia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 ETV6 NM_001987.4(ETV6): c.641C> T (p.Pro214Leu) single nucleotide variant Pathogenic/Likely pathogenic rs724159947 GRCh38 Chromosome 12, 11869601: 11869601
2 ETV6 NM_001987.4(ETV6): c.1106G> A (p.Arg369Gln) single nucleotide variant Pathogenic rs724159946 GRCh38 Chromosome 12, 11884541: 11884541
3 ETV6 NM_001987.4(ETV6): c.1195C> T (p.Arg399Cys) single nucleotide variant Pathogenic rs724159945 GRCh37 Chromosome 12, 12038902: 12038902
4 ETV6 NM_001987.4(ETV6): c.1153-5_1153-1delAACAG deletion Pathogenic rs786205154 GRCh37 Chromosome 12, 12038855: 12038859
5 ETV6 NM_001987.4(ETV6): c.1046T> C (p.Leu349Pro) single nucleotide variant Pathogenic rs786205155 GRCh37 Chromosome 12, 12037415: 12037415

Expression for Thrombocytopenia

Search GEO for disease gene expression data for Thrombocytopenia.

Pathways for Thrombocytopenia

Pathways related to Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 IL11 ITGA2 ITGA2B ITGB3 PF4 THPO
2
Show member pathways
13.07 APOH F2 F3 GATA1 GP1BA ITGA2
3 12.41 F2 ITGA2 ITGA2B ITGB3 MYH9 WAS
4
Show member pathways
11.98 F2 F3 GP1BA PF4
5
Show member pathways
11.91 GP1BA ITGA2 ITGA2B ITGB3
6 11.79 GP1BA ITGA2 ITGA2B ITGB3
7 11.63 ITGA2 ITGA2B ITGB3
8
Show member pathways
11.62 F2 GP1BA ITGA2B ITGB3 MPL THPO
9 11.61 CYCS ITGA2 ITGA2B
10 11.43 ITGA2 ITGA2B ITGB3
11 11.42 GP1BA IL11 ITGA2 ITGA2B ITGB3 THPO
12 11.33 F2 ITGA2 ITGA2B ITGB3
13 11.31 GATA1 ITGA2B ITGB3
14 11.24 GP1BA IL11 ITGA2 ITGA2B ITGB3 MPL
15 10.65 GP1BA ITGA2

GO Terms for Thrombocytopenia

Cellular components related to Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integrin complex GO:0008305 9.26 ITGA2 ITGA2B ITGB3 MYH9
2 cell surface GO:0009986 9.23 ADAMTS13 APOH F3 GP1BA ITGA2 ITGA2B
3 platelet alpha granule membrane GO:0031092 9.16 ITGA2B ITGB3

Biological processes related to Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.8 F3 GP1BA MPL PF4
2 platelet degranulation GO:0002576 9.78 APOH ITGA2B ITGB3 PF4
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.74 GATA1 IL11 ITGB3
4 cell-matrix adhesion GO:0007160 9.73 ADAMTS13 ITGA2 ITGA2B ITGB3
5 platelet activation GO:0030168 9.65 ADAMTS13 F2 GP1BA ITGB3 PF4
6 hemostasis GO:0007599 9.62 ADAMTS13 F2 F3 GP1BA
7 cell-substrate adhesion GO:0031589 9.61 ITGA2 ITGB3
8 cell adhesion mediated by integrin GO:0033627 9.6 ITGA2 ITGB3
9 actin filament-based movement GO:0030048 9.59 MYH9 WAS
10 positive regulation of blood coagulation GO:0030194 9.58 APOH F2
11 positive regulation of leukocyte migration GO:0002687 9.58 ITGA2 ITGA2B
12 regulation of blood coagulation GO:0030193 9.58 APOH F2 GP1BA
13 positive regulation of positive chemotaxis GO:0050927 9.56 F3 ITGA2
14 mesodermal cell differentiation GO:0048333 9.55 ITGA2 ITGB3
15 integrin-mediated signaling pathway GO:0007229 9.55 ADAMTS13 ITGA2 ITGA2B ITGB3 MYH9
16 response to amine GO:0014075 9.54 ADAMTS13 ITGA2
17 blood coagulation, intrinsic pathway GO:0007597 9.54 APOH F2 GP1BA
18 negative regulation of fibrinolysis GO:0051918 9.52 APOH F2
19 megakaryocyte differentiation GO:0030219 9.51 GATA1 IL11
20 thrombopoietin-mediated signaling pathway GO:0038163 9.46 MPL THPO
21 platelet aggregation GO:0070527 9.35 GATA1 GP1BA ITGA2B ITGB3 MYH9
22 blood coagulation GO:0007596 9.23 ADAMTS13 F2 F3 GATA1 GP1BA ITGA2

Sources for Thrombocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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