MCID: THR014
MIFTS: 71

Thrombocytopenia malady

Genetic diseases, Blood diseases, Rare diseases, Immune diseases, Fetal diseases categories
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Summaries for Thrombocytopenia

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Wikipedia:65 The terms thrombocytopenia and thrombopenia refer to a disorder in which there is a relative decrease of... more...

MalaCards based summary: Thrombocytopenia, also known as platelet count below reference range, is related to thrombocytopenia-absent radius syndrome and purpura. An important gene associated with Thrombocytopenia is WAS (Wiskott-Aldrich syndrome), and among its related pathways are Articular Cartilage Extracellular Matrix and Platelet Adhesion to exposed collagen. The drugs lepirudin and interferon alfa-2a and the compounds megapoietin and anagrelide have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and bone, and related mouse phenotypes are embryogenesis and renal/urinary system.

Aliases & Classifications for Thrombocytopenia

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Thrombocytopenia, Aliases & Descriptions:

Name: Thrombocytopenia 30 8 10 44 62
 
Platelet Count Below Reference Range 8


Classifications:



External Ids:

Disease Ontology8 DOID:1588
ICD9CM27 287.5
NCIt39 C3408
MeSH34 D013921

Related Diseases for Thrombocytopenia

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Diseases in the Myh9 Related Thrombocytopenia family:

thrombocytopenia Thrombocytopenia Due to Platelet Alloimmunization
Acquired Thrombocytopenia Thrombocytopenia 2
Mastl-Related Thrombocytopenia 2 Thrombocytopenia 4
Ankrd26-Related Thrombocytopenia 2 Gata1-Related Thrombocytopenia

Diseases related to Thrombocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 589)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia-absent radius syndrome31.6THPO
2purpura31.6THPO
3x-linked thrombocytopenia31.4WAS, THPO, GATA1
4thrombocytopenia 231.2ANKRD26
5wiskott-aldrich syndrome31.2GATA1, WAS, THPO
6congenital amegakaryocytic thrombocytopenia30.9IL3, MPL, THPO
7gray platelet syndrome30.9GATA1
8splenomegaly30.7THPO, MPL
9von willebrand's disease30.6GP1BA, ITGA2B
10myelofibrosis30.6MPL, THPO
11thrombocytopenia due to platelet alloimmunization30.5ITGA2B, MPL, THPO
12coronary thrombosis30.4ITGB3
13neutropenia30.3WAS, IL3, MPL, THPO
14glanzmann's thrombasthenia30.2ITGB3, ITGA2B
15autoimmune thrombocytopenic purpura30.2GP1BA, MPL, THPO, ITGB3
16thrombocytosis30.0THPO, GP1BA, MPL, IL3
17liver cirrhosis30.0ITGB3, THPO, MPL
18pancytopenia29.9THPO, MPL, IL3
19breast cancer29.8GATA1, ITGA2, GP1BA, CYCS
20bleeding disorder, platelet-type, 16, autosomal dominant29.8ITGB3, ITGA2B
21myocardial infarction29.8ITGB3, GP1BA, CYCS, ITGA2B, ITGA2
22deficiency anemia29.8MPL, IL3, THPO, GATA1
23acute leukemia29.8THPO, GATA1, MPL, IL3
24myelodysplastic syndromes29.7GATA1, IL3, MPL, THPO, GP1BA
25polycythemia29.6MPL, ITGB3, IL3, THPO
26myeloid leukemia29.6THPO, GATA1, IL3, MPL, CFI, CYCS
27polycythemia vera29.6IL3, ITGB3, MPL, THPO
28bernard-soulier syndrome29.6ITGA2, ITGA2B, ITGB3, GP1BA, THPO
29aplastic anemia29.5IL3, THPO, MPL, GP1BA, GATA1
30vascular disease29.4ITGA2, ITGB3, GP1BA
31rheumatoid arthritis29.4THPO, CFI, ITGA2, ITGB3
32leukemia29.4GATA1, MPL, ITGB3, ITGA2B, IL3, HOXA11
33ovarian cancer29.3CYCS, CFI, IL3, ITGA2, ITGB3
34chronic myeloid leukemia29.2THPO, GATA1, IL3, ITGB3, MPL
35heparin-induced thrombocytopenia11.2
36leukopenia10.7
37hepatitis10.6
38cyclic thrombocytopenia10.6
39hemolytic anemia10.5
40malaria10.5
41hepatitis c10.5
42hemangioma10.4
43lupus erythematosus10.4
44systemic lupus erythematosus10.4
45hemangioma thrombocytopenia syndrome10.4
46thrombocythemia 110.4THPO
47acquired thrombocytopenia10.4
48autoimmune hemolytic anemia10.4
49hypersplenism10.4
50hemorrhagic fever10.4

Graphical network of the top 20 diseases related to Thrombocytopenia:



Diseases related to thrombocytopenia

Symptoms for Thrombocytopenia

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Drugs & Therapeutics for Thrombocytopenia

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Genetic Tests for Thrombocytopenia

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Anatomical Context for Thrombocytopenia

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MalaCards organs/tissues related to Thrombocytopenia:

32
Liver, Testes, Bone, Bone marrow, T cells, Heart, Spleen, Skin, Myeloid, B cells, Endothelial, Kidney, Monocytes, Lung, Breast, Pituitary, Thyroid, Whole blood, Colon, Pancreas, Neutrophil, Lymph node, Ovary, Placenta, Prostate, Pineal

Animal Models for Thrombocytopenia or affiliated genes

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MGI Mouse Phenotypes related to Thrombocytopenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.1GATA1, MASTL, ITGA2B, ITGB3, MPL, CYCS
2MP:00053677.8ANKRD26, HOXA11, CFI, WAS, ITGB3, IL3
3MP:00053876.6GATA1, IL3, ITGA2B, ITGB3, MPL, CYCS
4MP:00053766.2MPL, GP1BA, ANKRD26, WAS, ITGB3, ITGA2B
5MP:00053976.1GATA1, IL3, ITGA2, ITGA2B, ITGB3, WAS
6MP:00053846.1GATA1, HOXA11, CYCS, GP1BA, MPL, WAS

Publications for Thrombocytopenia

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Articles related to Thrombocytopenia:

(show top 50)    (show all 2221)
idTitleAuthorsYear
1
Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia. (24438083)
2014
2
Dental procedures in 24 patients with chronic immune thrombocytopenia in prospective clinical studies of eltrombopag. (24433306)
2014
3
Therapeutic platelet transfusion for hypoproliferative thrombocytopenia - authors' reply. (23472916)
2013
4
Heparin-induced thrombocytopenia associated with thrombotic microangiopathy. (23715106)
2013
5
Argatroban in heparin-induced thrombocytopenia: rationale for use and place in therapy. (24179672)
2013
6
Oral eltrombopag for up to three years is safe and well-tolerated in Japanese patients with previously treated chronic immune thrombocytopenia: an open-label, extension study. (23896965)
2013
7
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
8
The I+IIb p.Leu841Met (Cab3(a+) ) polymorphism results in a new human platelet alloantigen involved in neonatal alloimmune thrombocytopenia. (22738334)
2013
9
A study of cytological changes in the bone marrow of patients with severe Fever with thrombocytopenia syndrome. (24349423)
2013
10
Rapidly Involuting Congenital Hemangioma Associated with Profound, Transient Thrombocytopenia. (22937785)
2012
11
Thrombocytopenia in HIV-Infected Patients. (23730018)
2012
12
Hemodialysis-associated acute systemic reactions and heparin-induced thrombocytopenia. (22127211)
2012
13
Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (22315270)
2012
14
What are the options for anticoagulation needs in dialysis for patients with heparin-induced thrombocytopenia? (21851394)
2011
15
A clinical-laboratory algorithm incorporating optical density value to predict heparin-induced thrombocytopenia. (21264443)
2011
16
Exacerbation of thrombocytopenia in a pregnant woman with thrombocytopenia-absent radius syndrome. (21530967)
2011
17
Novel use of plasmapheresis in a patient with heparin-induced thrombocytopenia requiring urgent insertion of a left ventricular assist device under cardiopulmonary bypass. (20723718)
2010
18
False-positive tests for heparin-induced thrombocytopenia in patients with antiphospholipid syndrome and systemic lupus erythematosus: a rebuttal. (20345710)
2010
19
Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban]. (19795099)
2009
20
Clonal chromosome anomalies and propensity to myeloid malignancies in congenital amegakaryocytic thrombocytopenia (OMIM 604498). (18519517)
2008
21
Serologic results in >1000 patients with suspected heparin-induced thrombocytopenia. (17895512)
2008
22
Successful treatment of autoimmune pancreatitis complicated with autoimmune thrombocytopenia and interstitial pneumonia by prednisolone. (18520116)
2008
23
Spontaneous superior sagittal sinus thrombosis secondary to type II heparin-induced thrombocytopenia presenting as an acute subarachnoid hemorrhage. (17582771)
2007
24
Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit. (17464135)
2007
25
Review article: pharmacological approaches for the treatment of thrombocytopenia in patients with chronic liver disease and hepatitis C infection. (17958517)
2007
26
Detection of 28 novel mutations in the Wiskott-Aldrich syndrome and X-linked thrombocytopenia based on multiplex PCR. (17400488)
2007
27
Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. (16466367)
2006
28
Successful renal transplantation in a patient with heterozygous prothrombin gene, factor V Leiden mutation and heparin-induced thrombocytopenia using r-hirudin as anticoagulant. (16499600)
2006
29
Use of ecarin clotting time in whole blood for monitoring recombinant hirudine treatment during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia]. (15771978)
2005
30
Patterns of thrombocytosis and thrombocytopenia in hospitalized neonates. (15578031)
2005
31
Mayer-Rokitansky-KA1ster-Hauser syndrome associated with thrombocytopenia-absent radius syndrome. (15705390)
2005
32
Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin-induced thrombocytopenia: an analysis of 3 prospective studies. (15280202)
2004
33
Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit. (12477267)
2002
34
Wilson disease manifested primarily as amenorrhea and accompanying thrombocytopenia. (12359384)
2002
35
Treatment of lupus-induced thrombocytopenia with recombinant human interleukin-11. (11212156)
2001
36
Mutations in the thrombopoietin receptor, Mpl, in children with congenital amegakaryocytic thrombocytopenia. (10971406)
2000
37
Sustained response to combination therapy in a patient with chronic hepatitis C and thrombocytopenia secondary to alpha-interferon. (10847447)
2000
38
Further examination of various administration protocols of pegylated recombinant human megakaryocyte growth and development factor on thrombocytopenia in myelosuppressed mice. (10227790)
1998
39
Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production. (8896400)
1996
40
Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia. (8826901)
1996
41
Osteopetrosis, anemia, thrombocytopenia, and marrow necrosis in beef calves naturally infected with bovine virus diarrhea virus. (8580185)
1995
42
Heparin-induced thrombocytopenia and thrombosis. (9372019)
1995
43
A case of common variable immunodeficiency associated with cyclic thrombocytopenia. (7871984)
1994
44
Dengue virus and endothelial cell: a related phenomenon to thrombocytopenia and granulocytopenia in dengue hemorrhagic fever. (7886587)
1993
45
The effect of a single course of alpha-2B-interferon in patients with HIV-related and chronic idiopathic immune thrombocytopenia. (8329555)
1993
46
Characterization of an antibody to the integrin beta 3 subunit (GP IIIa) from a patient with neonatal thrombocytopenia and an inherited deficiency of GP IIb-IIIa complexes in platelets (Glanzmann's thrombasthenia). (1633270)
1992
47
Plasma levels of endothelial-derived haemostatic factors in autoimmune thrombocytopenia and haemolytic anaemia. (2119418)
1990
48
Splenectomy for thrombocytopenia due to secondary hypersplenism. (3422554)
1988
49
Quinidine leukopenia and thrombocytopenia with a drug-dependent leukoagglutinin. (836544)
1977
50
Congenital lipomatosis of the pancreas. Malabsorption, dwarfism, leukopenia with relative granulocytopenia and thrombocytopenia. (5665293)
1968

Variations for Thrombocytopenia

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Expression for genes affiliated with Thrombocytopenia

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Expression patterns in normal tissues for genes affiliated with Thrombocytopenia

Search GEO for disease gene expression data for Thrombocytopenia.

Pathways for genes affiliated with Thrombocytopenia

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Pathways related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ITGA2, ITGA2B
29.7ITGA2, GP1BA
3
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.6MPL, THPO
49.4CYCS, ITGA2, ITGA2B
5
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.4ITGA2, ITGB3, WAS
69.3ITGB3, ITGA2B
79.3ITGB3, ITGA2B
89.3ITGA2B, ITGB3
99.0ITGA2, ITGB3, ITGA2B
109.0ITGA2, ITGA2B, ITGB3
11
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.0ITGB3, ITGA2B, ITGA2
129.0ITGA2B, ITGB3, ITGA2
139.0ITGB3, ITGA2B, ITGA2
14
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.0ITGB3, ITGA2, ITGA2B
159.0ITGB3, ITGA2, ITGA2B
16
Show member pathways
8.8ITGA2B, ITGA2, ITGB3, WAS
17
Show member pathways
8.8ITGA2, ITGB3, WAS, ITGA2B
18
Show member pathways
8.8WAS, ITGA2, ITGA2B, ITGB3
19
Show member pathways
8.8ITGA2, ITGA2B, ITGB3, WAS
20
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.5ITGA2, ITGA2B, ITGB3, GP1BA
21
Show member pathways
8.5ITGA2B, GATA1, ITGA2, ITGB3, CYCS
228.2ITGA2, ITGA2B, ITGB3, IL3
23
Show member pathways
7.9GP1BA, THPO, ITGB3, ITGA2B, MPL
24
Show member pathways
7.8THPO, ITGA2B, IL3, ITGA2, ITGB3
25
Show member pathways
7.8ITGB3, ITGA2, ITGA2B, THPO, IL3
26
Show member pathways
7.6THPO, WAS, ITGB3, ITGA2B, ITGA2, IL3
27
Show member pathways
7.5CYCS, ITGA2B, ITGA2, IL3, THPO, ITGB3
28
Show member pathways
7.5ITGA2B, ITGA2, ITGB3, THPO, CYCS, IL3
29
Show member pathways
7.4GP1BA, MPL, ITGA2B, THPO, ITGA2, GATA1
30
Show member pathways
7.4ITGA2B, ITGB3, MPL, IL3, ITGA2, THPO
317.3ITGA2B, GP1BA, ITGB3, THPO, ITGA2, IL3

Compounds for genes affiliated with Thrombocytopenia

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Compounds related to Thrombocytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1megapoietin4410.0MPL, THPO
2anagrelide44 1111.0THPO, MPL
3aebsf449.9CFI, CYCS
4convulxin449.9ITGA2, GP1BA
5aclarubicin449.7GATA1, IL3
6bio 1211619.7ITGB3, ITGA2B
7leukadherin 1619.7ITGB3, ITGA2B
8obtustatin619.7ITGB3, ITGA2B
9a 286982619.7ITGB3, ITGA2B
10tc-i 15619.7ITGA2B, ITGB3
11homoharringtonine44 50 1111.7CYCS, IL3
12mafosfamide449.6THPO, IL3
13pixy321449.6THPO, IL3
14thromboxane44 2410.5GATA1, THPO, MPL, ITGA2
15amifostine44 1110.5IL3, THPO
16tirofiban44 1110.5ITGA2, ITGA2B, ITGB3
17latex449.5WAS, GP1BA, THPO, ITGA2
18filgrastim44 1110.4IL3, THPO
19hydroxyurea44 50 1111.4GATA1, THPO, IL3
20cytarabine44 50 1111.3THPO, IL3, GATA1
21abciximab44 1110.2GP1BA, ITGB3, ITGA2B
22ristocetin449.2ITGB3, GP1BA
23gp 130449.1MPL, IL3, THPO
24proline449.1ITGB3, ITGA2, GP1BA, WAS
25phosphatidylcholine449.1IL3, ITGA2, CYCS
26actinomycin d449.1THPO, CYCS, IL3, GATA1
27iron44 2410.0GATA1, ITGB3, MPL, THPO
2812-o-tetradecanoylphorbol 13-acetate449.0IL3, ITGA2B, ITGA2, GATA1
29butyrate448.9CYCS, IL3, ITGA2, THPO, GATA1
30vegf448.8ITGB3, MPL, THPO, ITGA2, GATA1
31cycloheximide448.8GATA1, IL3, ITGA2, CYCS
32prostacyclin448.8IL3, GP1BA, THPO
33phosphatidylserine44 28 1110.7ITGB3, GP1BA, CYCS
34atp44 289.7WAS, THPO, RBM8A, CYCS, ITGA2, ITGB3
35lactate448.6GP1BA, CYCS, THPO, IL3
36aspirin44 50 28 2411.6MPL, ITGA2, ITGB3, GP1BA, THPO
37lysine448.6ITGA2, THPO, MPL, ITGB3, ITGA2B
38heparin44 28 24 1111.5THPO, CFI, GP1BA, ITGA2, IL3
39retinoic acid44 249.5THPO, CYCS, CFI, ITGA2, GATA1, IL3
40glucose448.4THPO, CFI, GP1BA, ITGB3, ITGA2
41estrogen448.2THPO, IL3, ITGB3, GATA1, CFI
42fibrinogen448.2THPO, CFI, ITGA2, ITGA2B, GP1BA, ITGB3
43phosphatidylinositol448.2WAS, ITGA2, IL3, MPL, GP1BA, THPO
44threonine448.1ITGA2, IL3, ITGB3, MPL, GP1BA
45calcium44 50 24 1110.8WAS, ITGA2, ITGA2B, THPO, CFI, GP1BA
46alanine447.8THPO, GP1BA, MPL, IL3, HOXA11, ITGB3
47adp44 28 249.6MPL, MASTL, ITGA2, ITGA2B, ITGB3, WAS
48tyrosine447.5IL3, ITGA2, ITGB3, THPO, GP1BA, WAS
49cysteine447.5ITGB3, ITGA2B, MPL, CYCS, THPO, ITGA2
50serine446.8CYCS, CFI, GP1BA, MPL, WAS, ITGB3

GO Terms for genes affiliated with Thrombocytopenia

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Cellular components related to Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1focal adhesionGO:0059259.0ITGA2, ITGA2B, ITGB3
2platelet alpha granule membraneGO:0310929.0ITGA2B, ITGB3
3integrin complexGO:0083059.0ITGA2, ITGA2B, ITGB3

Biological processes related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of leukocyte migrationGO:0026879.6ITGA2B, ITGA2
2embryonic hemopoiesisGO:0351629.4GATA1, IL3
3platelet aggregationGO:0705279.2GATA1, ITGA2B, ITGB3
4integrin-mediated signaling pathwayGO:0072299.1ITGB3, ITGA2B, ITGA2
5cell-matrix adhesionGO:0071609.1ITGA2, ITGA2B, ITGB3
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.9ITGB3, IL3, GATA1
7cell adhesionGO:0071558.2ITGA2, ITGA2B, ITGB3, GP1BA
8platelet activationGO:0301688.1THPO, GP1BA, MPL, ITGB3, ITGA2B
9blood coagulationGO:0075967.4GATA1, THPO, GP1BA, MPL, WAS, ITGB3

Products for genes affiliated with Thrombocytopenia

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Sources for Thrombocytopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet