MCID: THR014
MIFTS: 67

Thrombocytopenia malady

Blood diseases category

Summaries for Thrombocytopenia

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 The terms thrombocytopenia and thrombopenia, (British:- thrombocytopaenia and thrombopoenia,... more...

MalaCards: Thrombocytopenia, also known as platelet count below reference range, is related to thrombocytopenia-absent radius syndrome and wiskott-aldrich syndrome. An important gene associated with Thrombocytopenia is WAS (Wiskott-Aldrich syndrome), and among its related pathways are Hematopoietic cell lineage and Akt Signaling. The drugs lepirudin and interferon alfa-2a and the compounds tyrosine and fibrinogen have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and bone, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Aliases & Classifications for Thrombocytopenia

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

thrombocytopenia 8 10 44 30 60
platelet count below reference range 8


External Ids:

Disease Ontology8 DOID:1588
MeSH34 D013921
ICD9CM27 287.5
NCIt39 C3408

Related Diseases for Thrombocytopenia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Myh9 Related Thrombocytopenia family:

Thrombocytopenia Due to Platelet Alloimmunization Acquired Thrombocytopenia
thrombocytopenia Thrombocytopenia 2
Mastl-Related Thrombocytopenia 2 Thrombocytopenia 4
Ankrd26-Related Thrombocytopenia 2 Gata1-Related Thrombocytopenia

Diseases related to Thrombocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 509)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia-absent radius syndrome30.9THPO
2wiskott-aldrich syndrome30.7WAS, GATA1, THPO
3purpura30.7THPO
4leukemia30.7GATA1, ITGB3, MPL, CYCS, HOXA11, IL3
5x-linked thrombocytopenia30.7WAS, GATA1, ZFPM1, THPO
6acquired thrombocytopenia30.6IL11, THPO
7hepatitis c30.6THPO, CYCS
8lupus erythematosus30.5CYCS
9congenital amegakaryocytic thrombocytopenia30.5THPO, IL3, MPL
10hypersplenism30.5THPO
11acute leukemia30.4GATA1, MPL, IL3, IL11, THPO
12neutropenia30.4WAS, MPL, IL3, IL11, THPO
13autoimmune thrombocytopenic purpura30.4THPO, MPL, ITGB3
14thrombocytopenia due to platelet alloimmunization30.4THPO, GP5, MPL
15thrombocytosis30.4MPL, IL3, IL11, GP1BA, THPO
16von willebrand's disease30.3GP1BA, IL11
17myeloid leukemia30.2GATA1, MPL, CYCS, IL3, IL11, CFI
18liver cirrhosis30.2THPO, IL11, MPL, ITGB3
19thrombocytopenia 230.2MASTL, THC2
20disseminated intravascular coagulation30.2THPO
21myocardial infarction30.2GP1BA, IL11, CYCS, ITGA2, ITGB3
22myelofibrosis30.1THPO, MPL
23acute myocardial infarction30.1CYCS
24pneumonia30.1CYCS, IL11
25bernard-soulier syndrome30.1ITGB3, ITGA2, GP1BA, GP5, THPO
26aplastic anemia30.0GATA1, MPL, IL3, IL11, GP1BA, THPO
27polycythemia vera30.0THPO, IL3, MPL, ITGB3
28polycythemia30.0ITGB3, MPL, IL3, THPO
29pancytopenia30.0MPL, IL3, THPO
30sarcoma30.0THPO, CYCS
31pancreatitis30.0IL11
32coronary thrombosis30.0ITGB3
33arthritis30.0CYCS
34ovarian cancer29.9ITGB3, ITGA2, CYCS, IL3, IL11, CFI
35deficiency anemia29.9THPO, IL11, IL3, MPL, GATA1
36rheumatoid arthritis29.9ITGB3, ITGA2, IL11, CFI, THPO
37gray platelet syndrome29.9GP5, GATA1
38glanzmann's thrombasthenia29.9ITGB3
39splenic sequestration29.9THPO
40chronic myeloid leukemia29.8GATA1, ITGB3, MPL, IL3, IL11, THPO
41acute lymphocytic leukemia29.8THPO, IL3, MPL, GATA1
42myeloma29.5IL11, IL3, CYCS, ITGA2
43blood platelet disease29.5GP1BA, GP5, THPO
44cadasil29.5ITGB3, ITGA2, CYCS, GP1BA
45adenocarcinoma29.5ITGA2
46interstitial lung disease29.5CYCS
47hepatitis10.6
48hemolytic anemia10.5
49malaria10.4
50hemangioma10.4

Graphical network of the top 20 diseases related to Thrombocytopenia:



Diseases related to thrombocytopenia

Clinical Features for Thrombocytopenia

About this section

Drugs & Therapeutics for Thrombocytopenia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Thrombocytopenia

Drug clinical trials:

Search ClinicalTrials for Thrombocytopenia

Search NIH Clinical Center for Thrombocytopenia

Search CenterWatch for Thrombocytopenia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Thrombocytopenia cell therapies at LifeMap Discovery.

Genetic Tests for Thrombocytopenia

About this section

Anatomical Context for Thrombocytopenia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Thrombocytopenia:

32
Liver, Testes, Bone, Bone marrow, T cells, Heart, Spleen, Myeloid, Skin, B cells, Endothelial, Monocytes, Pituitary, Breast, Kidney, Thyroid, Lung, Whole blood, Colon, Pancreas, Prostate, Placenta, Ovary, Pineal

Animal Models for Thrombocytopenia or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Thrombocytopenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.3GATA1, WAS, ITGB3, ITGA2, MPL, CYCS
2MP:000537611.2GP5, CFI, WAS, ZFPM1, GATA1, ITGB3
3MP:000538410.8GP1BA, ZFPM1, IL3, HOXA11, CYCS, MPL
4MP:000536710.8CFI, ANKRD26, ITGB3, WAS

Publications for Thrombocytopenia

About this section
Sources:
50PubMed
See all sources

Articles related to Thrombocytopenia:

(show top 50)    (show all 2159)
idTitleAuthorsYear
1
Imbalanced expression of human Tim-1 and Tim-3 in peripheral blood mononuclear cells from immune thrombocytopenia patients. (24412470)
2014
2
Hepatopathy-Thrombocytopenia Syndrome During Actinomycin D Treatment May Be Related to MDR1 (ABCB1) Gene Polymorphisms. (24413370)
2014
3
Utility of cross-matched platelet transfusions in patients with hypoproliferative thrombocytopenia: a systematic review. (24032995)
2013
4
Innate and adaptive immunity in immune thrombocytopenia. (23664521)
2013
5
Rapidly involuting congenital hemangioma associated with transient anemia and thrombocytopenia. (23489172)
2013
6
Rituximab-induced acute thrombocytopenia: an underappreciated entity. (23488605)
2013
7
Individualized treatment for immune thrombocytopenia: predicting bleeding risk. (23664518)
2013
8
Interventions to reduce platelet prophylactic transfusions in patients with hypoproliferative thrombocytopenia: providing patients with the full benefit. (23865342)
2013
9
Safety and efficacy of romiplostim in patients with eltrombopag-resistant or -intolerant immune thrombocytopenia. (23862773)
2013
10
Non-recovery of ACT in a patient with heparin-induced thrombocytopenia type II during mitral valve replacement using argatroban anticoagulation. (23677498)
2013
11
Emphasis on the Role of PF4 in the Incidence, Pathophysiology and Treatment of Heparin Induced Thrombocytopenia. (23561460)
2013
12
Fondaparinux-associated heparin-induced thrombocytopenia. (23905719)
2013
13
Probable carvedilol-induced thrombocytopenia. (23515512)
2013
14
Apixaban as an alternate oral anticoagulant for the management of patients with heparin-induced thrombocytopenia. (23780399)
2013
15
Tirofiban-induced acute profound thrombocytopenia after primary angioplasty. (23430426)
2013
16
Refractory immune thrombocytopenia successfully treated with high-dose vitamin D supplementation and hydroxychloroquine: two case reports. (23556539)
2013
17
Leg ulcers revealing systemic sarcoidosis with splenomegaly and thrombocytopenia. (22804633)
2013
18
Current management of immune thrombocytopenia. (24319191)
2013
19
Effects of rapamycin combined with low dose prednisone in patients with chronic immune thrombocytopenia. (24363761)
2013
20
Uncommon complications of heparin-induced thrombocytopenia. (24157304)
2013
21
Challenges to the design and execution of controlled clinical studies of anticoagulants in patients with heparin-induced thrombocytopenia: lessons learned. (21918906)
2012
22
Congenital amegakaryocytic thrombocytopenia. (21337678)
2011
23
Diabetic ketoacidosis preceding thrombocytopenia associated multiple organ failure in a child. (21206100)
2011
24
Heparin-induced thrombocytopenia and extracorporeal membrane oxygenation: a case report and review of the literature. (21449228)
2011
25
Re: Heparin-induced thrombocytopenia - Type 2. (21897604)
2011
26
Thrombocytopenia-absent radius syndrome. (22102274)
2011
27
Thrombopoietin and thrombocytopenia in anorexia nervosa with severe liver dysfunction. (19810087)
2010
28
Physiological changes in membrane-expressed platelet factor 4: implications in heparin-induced thrombocytopenia. (19931120)
2010
29
Evaluation and management of thrombocytopenia and suspected heparin-induced thrombocytopenia in hospitalized patients: The Complications After Thrombocytopenia Caused by Heparin (CATCH) registry. (19332191)
2009
30
Heparin induced thrombocytopenia in patients with ventricular assistance device bridge-to-transplantation. A case series. (19092745)
2008
31
The role of platelet and plasma markers of antioxidant status and oxidative stress in thrombocytopenia among patients with vivax malaria. (18949318)
2008
32
Cytokines for the treatment of thrombocytopenia. (17631181)
2007
33
Endothelial cell damage in heparin-induced thrombocytopenia. (17473571)
2007
34
Impact of array comparative genomic hybridization-derived information on genetic counseling demonstrated by prenatal diagnosis of the TAR (thrombocytopenia-absent-radius) syndrome-associated microdeletion 1q21.1. (17847015)
2007
35
Acute thrombocytopenia after liver transplant: role of platelet activation, thrombopoietin deficiency and response to high dose intravenous IgG treatment. (17716776)
2007
36
Prevalence of heparin-induced thrombocytopenia in patients undergoing cardiac catheterization. (16875910)
2006
37
The efficacy and mechanism of rhIL-11 in the management of chemotherapy-induced thrombocytopenia in acute leukemia]. (16185478)
2005
38
Reduced intensity hematopoietic stem-cell transplantation across human leukocyte antigen barriers in a patient with congenital amegakaryocytic thrombocytopenia and monosomy 7. (15782403)
2005
39
Timely withdrawal of G-CSF reduces the occurrence of thrombocytopenia during dose-dense chemotherapy. (16187231)
2005
40
CNS siderosis and dandy-walker variant after neonatal alloimmune thrombocytopenia. (15866436)
2005
41
Subretinal hemorrhage associated with cytomegalovirus retinitis in a patient without concurrent thrombocytopenia. (15300084)
2004
42
Drug-induced immune thrombocytopenia: an overview of pathogenesis. (9930556)
1999
43
Further examination of various administration protocols of pegylated recombinant human megakaryocyte growth and development factor on thrombocytopenia in myelosuppressed mice. (10227790)
1998
44
Cyclic change of cytokines in a patient with cyclic thrombocytopenia. (8757531)
1996
45
Leukopenia and thrombocytopenia in a patient with early Lyme borreliosis. (8783732)
1996
46
Amifostine and chemotherapy-related thrombocytopenia. (8783667)
1996
47
Dengue virus and endothelial cell: a related phenomenon to thrombocytopenia and granulocytopenia in dengue hemorrhagic fever. (7886587)
1993
48
Prenatal diagnosis of thrombocytopenia absent radius syndrome by ultrasound and cordocentesis. (2179938)
1990
49
Splenectomy for thrombocytopenia due to secondary hypersplenism. (3422554)
1988
50
Prenatal diagnosis of thrombocytopenia absent radius syndrome using ultrasound and fetoscopy. (6739436)
1984

Genetic Variations for Thrombocytopenia

About this section

Expression for genes affiliated with Thrombocytopenia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Thrombocytopenia

Search GEO for disease gene expression data for Thrombocytopenia.

Pathways for genes affiliated with Thrombocytopenia

About this section
Sources:
29KEGG, 51QIAGEN, 53Reactome, 49PharmGKB
See all sources

Pathways related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0THPO, ITGB3, ITGA2, IL3, IL11, GP1BA
2
Hide members
10.9WAS, ITGB3, ITGA2, IL3, IL11, THPO
3
Hide members
10.9ITGB3, ITGA2, CYCS, IL3, IL11, THPO
4
Hide members
10.9ITGB3, ITGA2, MPL, IL3, IL11, THPO
5
Hide members
10.9ITGB3, ITGA2, CYCS, IL3, THPO
6
Hide members
10.9THPO, GP5, GP1BA, MPL, ITGB3
7
Hide members
10.8MPL, ITGA2, ITGB3, GATA1
8
Hide members
10.8ITGB3, ITGA2, GP1BA, GP5
9
Hide members
10.8THPO, GP5, GP1BA, ZFPM1
1010.7ITGA2, GP1BA, GP5
1110.7ITGB3, ITGA2, GP5
1210.6GP5, GP1BA

Compounds for genes affiliated with Thrombocytopenia

About this section
Sources:
44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
See all sources

Compounds related to Thrombocytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.5GP1BA, WAS, MPL, ITGA2, THPO, IL11
2fibrinogen4411.5ITGB3, ITGA2, IL11, GP1BA, GP5, THPO
3phosphatidylinositol4411.5GP1BA, THPO, IL3, MPL, ITGA2, WAS
4alanine4411.4IL3, THPO, GP1BA, IL11, MPL, HOXA11
5retinoic acid44 2412.4GATA1, ITGA2, IL11, CFI, CYCS, IL3
6cysteine4411.4CYCS, THPO, IL11, IL3, MPL, ITGA2
7butyrate4411.4GATA1, ITGA2, IL3, IL11, CYCS, THPO
8aspirin44 49 28 2414.4GP5, ITGB3, ITGA2, MPL, GP1BA, THPO
9serine4411.3GATA1, WAS, MPL, CYCS, GP1BA
10threonine4411.3ITGA2, ITGB3, GP1BA, IL11, IL3, MPL
11heparin44 28 11 2414.3THPO, CFI, GP1BA, IL11, ITGA2
12iron44 2412.3GATA1, ITGB3, IL11, THPO, MPL
13lactate4411.2CYCS, IL3, GP1BA, GP5, THPO
14thromboxane44 2412.2THPO, GATA1, MPL, ITGA2
15estrogen4411.2GATA1, THPO, CFI, IL11, IL3, ITGB3
16adp44 28 2413.2MPL, MASTL, WAS, ITGA2
17latex4411.2ITGA2, WAS, GP1BA, THPO
18gp 1304411.2IL11, MPL, IL3, THPO
19cytarabine44 49 1113.2GATA1, THPO, IL11, IL3
20cycloheximide4411.2IL11, IL3, CYCS, GATA1, ITGA2
21atp44 2812.2THPO, WAS, RBM8A, ITGB3, ITGA2, CYCS
22pixy3214411.2THPO, IL11, IL3
23amifostine44 1112.1IL3, IL11, THPO
245fluorouracil4411.1MPL, IL11, THPO, IL3
25filgrastim44 1112.1THPO, IL11, IL3
26polyacrylamide4411.1ITGB3, ITGA2, IL11, CFI
27glucose4411.1ITGB3, ITGA2, IL11, THPO, CFI, GP1BA
28epinephrine44 11 2413.1GP1BA, ITGA2, THPO, IL11
29etoposide44 49 59 1114.1THPO, IL3, CYCS, IL11
30gm-csf44 2812.1IL3, THPO, IL11
31ifosfamide44 1112.1IL3, THPO, IL11
32methylcellulose4411.1THPO, IL3, IL11
33vegf4411.1THPO, MPL, GATA1
3412-o-tetradecanoylphorbol 13-acetate4411.1IL11, GATA1, ITGA2, IL3
35megapoietin4411.0MPL, THPO
36carboplatin44 49 1113.0IL3, IL11, THPO
37il 114411.0IL3, IL11
38vitamin d4411.0IL11, IL3, GATA1, ITGB3
39mafosfamide4411.0IL3, THPO
40anagrelide44 1111.9MPL, THPO
41polyethylene glycol4410.9MPL, IL11, THPO
42aclarubicin4410.9IL3, GATA1
43homoharringtonine44 1111.9CYCS, IL3
44paclitaxel44 49 1112.9CYCS, IL3, IL11
45hydroxyurea44 49 1112.8THPO, IL3, GATA1
46actinomycin d4410.8THPO, CYCS, GATA1, IL3
47wortmannin4410.8WAS, THPO, IL11, IL3
48convulxin4410.7GP1BA, ITGA2
49idarubicin44 49 1112.5IL3, IL11
50doxorubicin44 49 1112.5IL11, IL3, GATA1, CYCS

GO Terms for genes affiliated with Thrombocytopenia

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.4THPO, WAS, GATA1, ITGB3, ITGA2, MPL
2platelet activationGO:03016811.2ITGB3, MPL, IL11, GP1BA, GP5, THPO
3positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.0GATA1, ITGB3, IL3, IL11
4megakaryocyte differentiationGO:03021910.9ZFPM1, IL11, GATA1
5embryonic hemopoiesisGO:03516210.9ZFPM1, IL3, GATA1
6transcriptional activation by promoter-enhancer loopingGO:07173310.8ZFPM1, GATA1
7regulation of chemokine productionGO:03264210.7MPL, ZFPM1
8cell-matrix adhesionGO:00716010.7GP5, ITGA2, ITGB3
9regulation of definitive erythrocyte differentiationGO:01072410.7GATA1, ZFPM1
10blood coagulation, intrinsic pathwayGO:00759710.6GP5, GP1BA
11platelet formationGO:03022010.5GATA1, ZFPM1
12platelet aggregationGO:07052710.3ITGB3, GATA1

Products for genes affiliated with Thrombocytopenia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thrombocytopenia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet