MCID: THR014
MIFTS: 67

Thrombocytopenia malady

Blood diseases category

Summaries for Thrombocytopenia

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63Wikipedia, 32MalaCards
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Wikipedia:63 The terms thrombocytopenia and thrombopenia, (British:- thrombocytopaenia and thrombopoenia,... more...

MalaCards: Thrombocytopenia, also known as platelet count below reference range, is related to thrombocytopenia-absent radius syndrome and wiskott-aldrich syndrome. An important gene associated with Thrombocytopenia is WAS (Wiskott-Aldrich syndrome), and among its related pathways are Hematopoietic cell lineage and Akt Signaling. The drugs lepirudin and interferon alfa-2a and the compounds tyrosine and fibrinogen have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Aliases & Classifications for Thrombocytopenia

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

thrombocytopenia 8 10 44 30 60
platelet count below reference range 8


External Ids:

Disease Ontology8 DOID:1588
MeSH34 D013921
ICD9CM27 287.5
NCIt39 C3408

Related Diseases for Thrombocytopenia

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17GeneCards, 18GeneDecks
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Diseases in the Myh9 Related Thrombocytopenia family:

Thrombocytopenia Due to Platelet Alloimmunization Acquired Thrombocytopenia
thrombocytopenia Thrombocytopenia 2
Mastl-Related Thrombocytopenia 2 Thrombocytopenia 4
Ankrd26-Related Thrombocytopenia 2 Gata1-Related Thrombocytopenia

Diseases related to Thrombocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 509)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia-absent radius syndrome30.9THPO
2wiskott-aldrich syndrome30.7WAS, GATA1, THPO
3purpura30.7THPO
4leukemia30.7GATA1, ITGB3, MPL, CYCS, HOXA11, IL3
5x-linked thrombocytopenia30.7WAS, GATA1, ZFPM1, THPO
6acquired thrombocytopenia30.6IL11, THPO
7hepatitis c30.6THPO, CYCS
8lupus erythematosus30.5CYCS
9congenital amegakaryocytic thrombocytopenia30.5THPO, IL3, MPL
10hypersplenism30.5THPO
11acute leukemia30.4GATA1, MPL, IL3, IL11, THPO
12neutropenia30.4WAS, MPL, IL3, IL11, THPO
13autoimmune thrombocytopenic purpura30.4THPO, MPL, ITGB3
14thrombocytopenia due to platelet alloimmunization30.4THPO, GP5, MPL
15thrombocytosis30.4MPL, IL3, IL11, GP1BA, THPO
16von willebrand's disease30.3GP1BA, IL11
17myeloid leukemia30.2GATA1, MPL, CYCS, IL3, IL11, CFI
18liver cirrhosis30.2THPO, IL11, MPL, ITGB3
19thrombocytopenia 230.2MASTL, THC2
20disseminated intravascular coagulation30.2THPO
21myocardial infarction30.2GP1BA, IL11, CYCS, ITGA2, ITGB3
22myelofibrosis30.1THPO, MPL
23acute myocardial infarction30.1CYCS
24pneumonia30.1CYCS, IL11
25bernard-soulier syndrome30.1ITGB3, ITGA2, GP1BA, GP5, THPO
26aplastic anemia30.0GATA1, MPL, IL3, IL11, GP1BA, THPO
27polycythemia vera30.0THPO, IL3, MPL, ITGB3
28polycythemia30.0ITGB3, MPL, IL3, THPO
29pancytopenia30.0MPL, IL3, THPO
30sarcoma30.0THPO, CYCS
31pancreatitis30.0IL11
32coronary thrombosis30.0ITGB3
33arthritis30.0CYCS
34ovarian cancer29.9ITGB3, ITGA2, CYCS, IL3, IL11, CFI
35deficiency anemia29.9THPO, IL11, IL3, MPL, GATA1
36rheumatoid arthritis29.9ITGB3, ITGA2, IL11, CFI, THPO
37gray platelet syndrome29.9GP5, GATA1
38glanzmann's thrombasthenia29.9ITGB3
39splenic sequestration29.9THPO
40chronic myeloid leukemia29.8GATA1, ITGB3, MPL, IL3, IL11, THPO
41acute lymphocytic leukemia29.8THPO, IL3, MPL, GATA1
42myeloma29.5IL11, IL3, CYCS, ITGA2
43blood platelet disease29.5GP1BA, GP5, THPO
44cadasil29.5ITGB3, ITGA2, CYCS, GP1BA
45adenocarcinoma29.5ITGA2
46interstitial lung disease29.5CYCS
47hepatitis10.6
48hemolytic anemia10.5
49malaria10.4
50hemangioma10.4

Graphical network of the top 20 diseases related to Thrombocytopenia:



Diseases related to thrombocytopenia

Clinical Features for Thrombocytopenia

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Drugs & Therapeutics for Thrombocytopenia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Thrombocytopenia

Drug clinical trials:

Search ClinicalTrials for Thrombocytopenia

Search NIH Clinical Center for Thrombocytopenia

Search CenterWatch for Thrombocytopenia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Thrombocytopenia cell therapies at LifeMap Discovery.

Genetic Tests for Thrombocytopenia

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Anatomical Context for Thrombocytopenia

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32MalaCards
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MalaCards organs/tissues related to Thrombocytopenia:

32
Liver, Bone, Testes, Bone marrow, T cells, Heart, Spleen, Myeloid, Skin, B cells, Endothelial, Monocytes, Pituitary, Kidney, Breast, Thyroid, Lung, Whole blood, Colon, Pancreas, Ovary, Prostate, Pineal, Placenta

Animal Models for Thrombocytopenia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thrombocytopenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.3THPO, WAS, GATA1, ITGB3, ITGA2, MPL
2MP:000537611.2WAS, GATA1, ITGB3, ITGA2, MPL, ANKRD26
3MP:000538410.8WAS, GATA1, MPL, CYCS, HOXA11, IL3
4MP:000536710.8CFI, ANKRD26, ITGB3, WAS

Publications for Thrombocytopenia

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Sources:
50PubMed
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Articles related to Thrombocytopenia:

(show top 50)    (show all 2159)
idTitleAuthorsYear
1
Newly Diagnosed Immune Thrombocytopenia: Update on Diagnosis and Management. (24091868)
2013
2
G-CSF plus plerixafor (Mozobil) to mobilize hematopoietic stem cells in patients with thrombocytopenia or leukopenia prior to auto-SCT. (22773123)
2013
3
Congenital amegakaryocytic thrombocytopenia (CAMT) presenting as severe pancytopenia in the first month of life. (23625800)
2013
4
Efficacy and safety of laparoscopic splenectomy in thrombocytopenia secondary to systemic lupus erythematosus. (23549638)
2013
5
Severe thrombocytopenia due to hypersplenism treated with partial splenic embolisation. (23833091)
2013
6
Study of thrombocytopenia in patients of malaria. (23961443)
2013
7
Rituximab in Previously Treated Primary Immune Thrombocytopenia Patients: Evaluation of Short- and Long-Term Efficacy and Safety. (24356282)
2013
8
Thrombotic risk in patients with immune thrombocytopenia and its association with antiphospholipid antibodies. (23530551)
2013
9
Fatal anaphylactoid reaction associated with heparin-induced thrombocytopenia. (23579400)
2013
10
B cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia. (24357731)
2013
11
Clinical and laboratory features of 103 patients from 42 Italian families with inherited thrombocytopenia derived from the monoallelic Ala156Val mutation of GPIbI+ (Bolzano mutation). (21933849)
2012
12
Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis. (22990018)
2012
13
High rates of venous thromboembolism prophylaxis did not increase the incidence of heparin-induced thrombocytopenia. (21500716)
2011
14
Analysis of 12,517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherited traits. (20823129)
2011
15
Endovascular management of acute infrarenal aortic thrombosis caused by heparin-induced thrombocytopenia in a patient treated with low molecular weight heparin. (21292503)
2011
16
Assessment of the 4Ts pretest clinical scoring system as a predictor of heparin-induced thrombocytopenia. (21275492)
2011
17
Serum thrombopoietin level and thrombocytopenia during the neonatal period in infants with Down's syndrome. (19675574)
2010
18
Fondaparinux therapy in a hemodialysis patient with heparin-induced thrombocytopenia type II. (20554593)
2010
19
Lepirudin-induced thrombocytopenia following subcutaneous administration. (19386946)
2009
20
Thrombocytopenia and thrombosis in disseminated intravascular coagulation (DIC). (20008204)
2009
21
Argatroban therapy in heparin-induced thrombocytopenia. (19174636)
2009
22
Platelet PlA2 Polymorphism and the risk for thrombosis in heparin-induced thrombocytopenia. (18208809)
2008
23
MBL2 gene polymorphisms protect against development of thrombocytopenia associated with severe dengue phenotype. (18361938)
2008
24
Management of anticoagulation in patients with subacute heparin-induced thrombocytopenia scheduled for heart transplantation. (18791163)
2008
25
Detection of 28 novel mutations in the Wiskott-Aldrich syndrome and X-linked thrombocytopenia based on multiplex PCR. (17400488)
2007
26
Profound thrombocytopenia related to G-CSF. (17034024)
2007
27
A case of suspected lymphocytic hypophysitis and organizing pneumonia during maintenance therapy for autoimmune pancreatitis associated with autoimmune thrombocytopenia. (16849834)
2006
28
Acute eosinophilic pneumonia accompanied by mediastinal lymphadenopathy and thrombocytopenia. (17128696)
2006
29
Incidence of heparin-induced thrombocytopenia and therapeutic strategies in pediatric cardiac surgery. (15620916)
2005
30
Phase II clinical trial on China manufactured recombinant human interleukin-11 derivative in the prevention and treatment of chemotherapy-induced thrombocytopenia]. (16117903)
2005
31
Impact of in-hospital acquired thrombocytopenia in patients undergoing primary angioplasty for acute myocardial infarction. (16098296)
2005
32
A 32-year old male patient with pathological humeral fracture, splenomegaly and thrombocytopenia]. (15151139)
2004
33
Cyclic thrombocytopenia and polycythemia vera. (12574969)
2003
34
Leukopenia and thrombocytopenia in pigs after infection with bovine viral diarrhoea virus-2 (BVDV-2). (12073495)
2002
35
Serum thrombopoietin levels in patients correlate inversely with platelet counts during chemotherapy-induced thrombocytopenia. (9529122)
1998
36
Thrombocytopenia in preeclampsia: an earlier detector of HELLP syndrome. (9361486)
1997
37
Multiple quinine-dependent antibodies in a patient with episodic thrombocytopenia, neutropenia, lymphocytopenia, and granulomatous hepatitis. (9389697)
1997
38
Pathogenicity of human anti-platelet factor 4 (PF4)/heparin in vivo: generation of mouse anti-PF4/heparin and induction of thrombocytopenia by heparin. (9158107)
1997
39
Lupus anticoagulant, heparin use, and thrombocytopenia in patients with chronic thromboembolic pulmonary hypertension: a preliminary report. (7573095)
1995
40
Anticardiolipin antibody-related thrombocytopenia: persistent remission after splenectomy. (7672720)
1995
41
Bone marrow transplantation in two children with congenital amegakaryocytic thrombocytopenia. (7670411)
1995
42
Malignant histiocytosis associated with autoimmune thrombocytopenia. (8296797)
1994
43
Septicemic listeriosis, thrombocytopenia, blood parasitism, and hepatopathy in a llama. (8144379)
1994
44
The effect of a single course of alpha-2B-interferon in patients with HIV-related and chronic idiopathic immune thrombocytopenia. (8329555)
1993
45
Pregnancy-induced worsening of thrombocytopenia in a patient with type IIB von Willebrand's disease. (1772996)
1991
46
A patient with mevalonic aciduria presenting with hepatosplenomegaly, congenital anaemia, thrombocytopenia and leukocytosis. (3141709)
1988
47
Quinidine leukopenia and thrombocytopenia with a drug-dependent leukoagglutinin. (836544)
1977
48
Concurrence of varicose osteo-hypertrophic nevus (Klippel-Trenaunay), visceral angiomatosis and thrombocytopenia (Kasabach-Merrit). A case report. (5716300)
1968
49
CONGENITAL THYROTOXICOSIS WITH HEPATOSPLENOMEGALY AND THROMBOCYTOPENIA, ASSOCIATED WITH ANIRIDIA AND DISLOCATED LENSES. (14291254)
1965
50
Congenital amegakaryocytic thrombocytopenia with congenital deformities and a leukemoid blood picture in the newborn. (13436513)
1957

Genetic Variations for Thrombocytopenia

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Expression for genes affiliated with Thrombocytopenia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thrombocytopenia

Search GEO for disease gene expression data for Thrombocytopenia.

Pathways for genes affiliated with Thrombocytopenia

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29KEGG, 51QIAGEN, 53Reactome, 49PharmGKB
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Pathways related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0THPO, ITGB3, ITGA2, IL3, IL11, GP1BA
2
Hide members
10.9WAS, ITGB3, ITGA2, IL3, IL11, THPO
3
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10.9ITGB3, ITGA2, CYCS, IL3, IL11, THPO
4
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10.9ITGB3, ITGA2, MPL, IL3, IL11, THPO
5
Hide members
10.9ITGB3, ITGA2, CYCS, IL3, THPO
6
Hide members
10.9THPO, GP5, GP1BA, MPL, ITGB3
7
Hide members
10.8MPL, ITGA2, ITGB3, GATA1
8
Hide members
10.8ITGB3, ITGA2, GP1BA, GP5
9
Hide members
10.8THPO, GP5, GP1BA, ZFPM1
1010.7ITGA2, GP1BA, GP5
1110.7ITGB3, ITGA2, GP5
1210.6GP5, GP1BA

Compounds for genes affiliated with Thrombocytopenia

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44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Thrombocytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.5WAS, ITGB3, ITGA2, MPL, IL3, IL11
2fibrinogen4411.5THPO, ITGB3, ITGA2, IL11, GP1BA, GP5
3phosphatidylinositol4411.5WAS, ITGA2, MPL, IL3, IL11, GP1BA
4alanine4411.4ITGB3, MPL, HOXA11, IL3, IL11, GP1BA
5retinoic acid44 2412.4GATA1, ITGA2, CYCS, IL3, IL11, CFI
6cysteine4411.4ITGB3, ITGA2, MPL, CYCS, IL3, IL11
7butyrate4411.4GATA1, ITGA2, CYCS, IL3, IL11, THPO
8aspirin44 49 28 2414.4ITGB3, ITGA2, MPL, GP1BA, GP5, THPO
9serine4411.3WAS, GATA1, MPL, CYCS, GP1BA
10threonine4411.3ITGB3, ITGA2, MPL, IL3, IL11, GP1BA
11heparin44 28 11 2414.3ITGA2, IL11, GP1BA, CFI, THPO
12iron44 2412.3THPO, IL11, MPL, ITGB3, GATA1
13lactate4411.2CYCS, IL3, GP1BA, GP5, THPO
14thromboxane44 2412.2THPO, MPL, ITGA2, GATA1
15estrogen4411.2GATA1, ITGB3, IL3, IL11, CFI, THPO
16adp44 28 2413.2MASTL, MPL, ITGA2, WAS
17latex4411.2WAS, ITGA2, GP1BA, THPO
18gp 1304411.2MPL, IL3, IL11, THPO
19cytarabine44 49 1113.2GATA1, IL3, IL11, THPO
20cycloheximide4411.2GATA1, ITGA2, CYCS, IL3, IL11
21atp44 2812.2WAS, RBM8A, ITGB3, ITGA2, CYCS, THPO
22pixy3214411.2IL3, IL11, THPO
23amifostine44 1112.1IL3, IL11, THPO
245fluorouracil4411.1THPO, IL11, IL3, MPL
25filgrastim44 1112.1THPO, IL11, IL3
26polyacrylamide4411.1ITGB3, ITGA2, IL11, CFI
27glucose4411.1ITGB3, ITGA2, IL11, GP1BA, CFI, THPO
28epinephrine44 11 2413.1ITGA2, IL11, GP1BA, THPO
29etoposide44 49 59 1114.1THPO, IL11, IL3, CYCS
30gm-csf44 2812.1THPO, IL11, IL3
31ifosfamide44 1112.1THPO, IL11, IL3
32methylcellulose4411.1IL3, IL11, THPO
33vegf4411.1GATA1, MPL, THPO
3412-o-tetradecanoylphorbol 13-acetate4411.1IL11, IL3, ITGA2, GATA1
35megapoietin4411.0THPO, MPL
36carboplatin44 49 1113.0IL3, IL11, THPO
37il 114411.0IL11, IL3
38vitamin d4411.0GATA1, ITGB3, IL3, IL11
39mafosfamide4411.0THPO, IL3
40anagrelide44 1111.9THPO, MPL
41polyethylene glycol4410.9THPO, IL11, MPL
42homoharringtonine44 1111.9CYCS, IL3
43aclarubicin4410.9GATA1, IL3
44paclitaxel44 49 1112.9IL11, IL3, CYCS
45hydroxyurea44 49 1112.8GATA1, IL3, THPO
46actinomycin d4410.8THPO, IL3, CYCS, GATA1
47convulxin4410.7GP1BA, ITGA2
48wortmannin4410.7WAS, IL3, IL11, THPO
49idarubicin44 49 1112.6IL3, IL11
50doxorubicin44 49 1112.5GATA1, CYCS, IL3, IL11

GO Terms for genes affiliated with Thrombocytopenia

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16Gene Ontology
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Biological processes related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.4THPO, WAS, GATA1, ITGB3, ITGA2, MPL
2platelet activationGO:03016811.2ITGB3, MPL, IL11, GP1BA, GP5, THPO
3positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.0GATA1, ITGB3, IL3, IL11
4megakaryocyte differentiationGO:03021910.9ZFPM1, IL11, GATA1
5embryonic hemopoiesisGO:03516210.9ZFPM1, IL3, GATA1
6transcriptional activation by promoter-enhancer loopingGO:07173310.8ZFPM1, GATA1
7regulation of chemokine productionGO:03264210.7MPL, ZFPM1
8cell-matrix adhesionGO:00716010.7GP5, ITGA2, ITGB3
9regulation of definitive erythrocyte differentiationGO:01072410.7GATA1, ZFPM1
10blood coagulation, intrinsic pathwayGO:00759710.6GP5, GP1BA
11platelet formationGO:03022010.5GATA1, ZFPM1
12platelet aggregationGO:07052710.3ITGB3, GATA1

Products for genes affiliated with Thrombocytopenia

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  • Antibodies
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  • Antibodies

Sources for Thrombocytopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet