MCID: THR014
MIFTS: 70

Thrombocytopenia malady

Genetic diseases, Blood diseases, Rare diseases, Immune diseases, Fetal diseases categories

Summaries for Thrombocytopenia

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66Wikipedia, 34MalaCards
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Wikipedia:66 The terms thrombocytopenia and thrombopenia, refer to a relative decrease of platelets in blood. more...

MalaCards: Thrombocytopenia, also known as platelet count below reference range, is related to thrombocytopenia-absent radius syndrome and x-linked thrombocytopenia. An important gene associated with Thrombocytopenia is WAS (Wiskott-Aldrich syndrome), and among its related pathways are Articular Cartilage Extracellular Matrix and Platelet Adhesion to exposed collagen. The drugs lepirudin and interferon alfa-2a and the compounds megapoietin and anagrelide have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related mouse phenotypes are embryogenesis and renal/urinary system.

Aliases & Classifications for Thrombocytopenia

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 32LifeMap Discoveryā„¢, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 28ICD9CM
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Classifications:



Aliases & Descriptions:

thrombocytopenia 9 11 46 32 63
platelet count below reference range 9


External Ids:

Disease Ontology9 DOID:1588
NCIt41 C3408
MeSH36 D013921
ICD9CM28 287.5

Related Diseases for Thrombocytopenia

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18GeneCards, 19GeneDecks
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Diseases in the Myh9 Related Thrombocytopenia family:

Thrombocytopenia Due to Platelet Alloimmunization Acquired Thrombocytopenia
thrombocytopenia Thrombocytopenia 2
Mastl-Related Thrombocytopenia 2 Thrombocytopenia 4
Ankrd26-Related Thrombocytopenia 2 Gata1-Related Thrombocytopenia

Diseases related to Thrombocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 577)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia-absent radius syndrome31.1THPO
2x-linked thrombocytopenia31.1WAS, THPO, GATA1
3purpura31.0THPO
4congenital amegakaryocytic thrombocytopenia30.9IL3, MPL, THPO
5wiskott-aldrich syndrome30.9GATA1, WAS, THPO
6splenomegaly30.5THPO, MPL
7thrombocytopenia 230.5ANKRD26
8von willebrand's disease30.5GP1BA, ITGA2B
9thrombocytopenia due to platelet alloimmunization30.4ITGA2B, MPL, THPO
10neutropenia30.4WAS, IL3, MPL, THPO
11leukemia30.4GATA1, MPL, ITGB3, ITGA2B, IL3, HOXA11
12autoimmune thrombocytopenic purpura30.4GP1BA, MPL, THPO, ITGB3
13thrombocytosis30.3THPO, GP1BA, MPL, IL3
14gray platelet syndrome30.3GATA1
15myelofibrosis30.3MPL, THPO
16myelodysplastic syndromes30.2GATA1, IL3, MPL, THPO, GP1BA
17myocardial infarction30.1ITGB3, GP1BA, CYCS, ITGA2B, ITGA2
18myeloid leukemia30.1THPO, GATA1, IL3, MPL, CFI, CYCS
19liver cirrhosis30.1ITGB3, THPO, MPL
20coronary thrombosis30.1ITGB3
21glanzmann's thrombasthenia30.0ITGB3, ITGA2B
22bernard-soulier syndrome30.0ITGA2, ITGA2B, ITGB3, GP1BA, THPO
23breast cancer30.0GATA1, ITGA2, GP1BA, CYCS
24acute leukemia30.0THPO, GATA1, MPL, IL3
25polycythemia29.9MPL, ITGB3, IL3, THPO
26polycythemia vera29.9IL3, ITGB3, MPL, THPO
27pancytopenia29.9THPO, MPL, IL3
28aplastic anemia29.9IL3, THPO, MPL, GP1BA, GATA1
29deficiency anemia29.9MPL, IL3, THPO, GATA1
30rheumatoid arthritis29.8THPO, CFI, ITGA2, ITGB3
31ovarian cancer29.8CYCS, CFI, IL3, ITGA2, ITGB3
32acute lymphocytic leukemia29.8GATA1, MPL, THPO, IL3
33chronic myeloid leukemia29.7THPO, GATA1, IL3, ITGB3, MPL
34vascular disease29.6ITGA2, ITGB3, GP1BA
35myeloproliferative disorder29.5ITGB3, GATA1, IL3, MPL, THPO
36heparin-induced thrombocytopenia11.2
37leukopenia10.6
38hepatitis10.6
39cyclic thrombocytopenia10.6
40hemolytic anemia10.5
41hepatitis c10.4
42malaria10.4
43hemangioma10.4
44lupus erythematosus10.4
45systemic lupus erythematosus10.4
46hemangioma thrombocytopenia syndrome10.4
47hemorrhagic fever10.4
48hypersplenism10.4
49autoimmune hemolytic anemia10.3
50acquired thrombocytopenia10.3

Graphical network of the top 20 diseases related to Thrombocytopenia:



Diseases related to thrombocytopenia

Symptoms for Thrombocytopenia

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Drugs & Therapeutics for Thrombocytopenia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Thrombocytopenia

Drug clinical trials:

Search ClinicalTrials for Thrombocytopenia

Search NIH Clinical Center for Thrombocytopenia

Search CenterWatch for Thrombocytopenia

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Thrombocytopenia cell therapies at LifeMap Discovery.

Genetic Tests for Thrombocytopenia

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Anatomical Context for Thrombocytopenia

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34MalaCards
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MalaCards organs/tissues related to Thrombocytopenia:

34
Liver, Bone, Testes, Bone marrow, T cells, Spleen, Heart, Myeloid, Skin, B cells, Endothelial, Monocytes, Pituitary, Kidney, Breast, Thyroid, Lung, Whole blood, Colon, Pancreas, Ovary, Prostate, Pineal, Placenta

Animal Models for Thrombocytopenia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Thrombocytopenia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.1MPL, ITGB3, ITGA2B, MASTL, GATA1, CYCS
2MP:00053677.8HOXA11, CFI, WAS, ANKRD26, ITGB3, IL3
3MP:00053876.6THPO, CYCS, MPL, WAS, ITGB3, ITGA2B
4MP:00053766.2WAS, MPL, GP1BA, CFI, ANKRD26, ITGB3
5MP:00053976.1MPL, GP1BA, CYCS, THPO, WAS, ITGB3
6MP:00053846.1GATA1, HOXA11, CYCS, GP1BA, MPL, WAS

Publications for Thrombocytopenia

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53PubMed
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Articles related to Thrombocytopenia:

(show top 50)    (show all 2135)
idTitleAuthorsYear
1
Dental procedures in 24 patients with chronic immune thrombocytopenia in prospective clinical studies of eltrombopag. (24433306)
2014
2
Therapeutic platelet transfusion for hypoproliferative thrombocytopenia - authors' reply. (23472916)
2013
3
Heparin-induced thrombocytopenia associated with thrombotic microangiopathy. (23715106)
2013
4
Argatroban in heparin-induced thrombocytopenia: rationale for use and place in therapy. (24179672)
2013
5
Oral eltrombopag for up to three years is safe and well-tolerated in Japanese patients with previously treated chronic immune thrombocytopenia: an open-label, extension study. (23896965)
2013
6
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
7
The I+IIb p.Leu841Met (Cab3(a+) ) polymorphism results in a new human platelet alloantigen involved in neonatal alloimmune thrombocytopenia. (22738334)
2013
8
A study of cytological changes in the bone marrow of patients with severe Fever with thrombocytopenia syndrome. (24349423)
2013
9
Rapidly Involuting Congenital Hemangioma Associated with Profound, Transient Thrombocytopenia. (22937785)
2012
10
Thrombocytopenia in HIV-Infected Patients. (23730018)
2012
11
Hemodialysis-associated acute systemic reactions and heparin-induced thrombocytopenia. (22127211)
2012
12
Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (22315270)
2012
13
Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus. (22869835)
2012
14
What are the options for anticoagulation needs in dialysis for patients with heparin-induced thrombocytopenia? (21851394)
2011
15
A clinical-laboratory algorithm incorporating optical density value to predict heparin-induced thrombocytopenia. (21264443)
2011
16
Exacerbation of thrombocytopenia in a pregnant woman with thrombocytopenia-absent radius syndrome. (21530967)
2011
17
Novel use of plasmapheresis in a patient with heparin-induced thrombocytopenia requiring urgent insertion of a left ventricular assist device under cardiopulmonary bypass. (20723718)
2010
18
False-positive tests for heparin-induced thrombocytopenia in patients with antiphospholipid syndrome and systemic lupus erythematosus: a rebuttal. (20345710)
2010
19
Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban]. (19795099)
2009
20
Clonal chromosome anomalies and propensity to myeloid malignancies in congenital amegakaryocytic thrombocytopenia (OMIM 604498). (18519517)
2008
21
Serologic results in >1000 patients with suspected heparin-induced thrombocytopenia. (17895512)
2008
22
Successful treatment of autoimmune pancreatitis complicated with autoimmune thrombocytopenia and interstitial pneumonia by prednisolone. (18520116)
2008
23
Spontaneous superior sagittal sinus thrombosis secondary to type II heparin-induced thrombocytopenia presenting as an acute subarachnoid hemorrhage. (17582771)
2007
24
Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit. (17464135)
2007
25
Review article: pharmacological approaches for the treatment of thrombocytopenia in patients with chronic liver disease and hepatitis C infection. (17958517)
2007
26
Detection of 28 novel mutations in the Wiskott-Aldrich syndrome and X-linked thrombocytopenia based on multiplex PCR. (17400488)
2007
27
Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. (16466367)
2006
28
Successful renal transplantation in a patient with heterozygous prothrombin gene, factor V Leiden mutation and heparin-induced thrombocytopenia using r-hirudin as anticoagulant. (16499600)
2006
29
Use of ecarin clotting time in whole blood for monitoring recombinant hirudine treatment during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia]. (15771978)
2005
30
Patterns of thrombocytosis and thrombocytopenia in hospitalized neonates. (15578031)
2005
31
Mayer-Rokitansky-KA1ster-Hauser syndrome associated with thrombocytopenia-absent radius syndrome. (15705390)
2005
32
Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin-induced thrombocytopenia: an analysis of 3 prospective studies. (15280202)
2004
33
Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit. (12477267)
2002
34
Wilson disease manifested primarily as amenorrhea and accompanying thrombocytopenia. (12359384)
2002
35
Treatment of lupus-induced thrombocytopenia with recombinant human interleukin-11. (11212156)
2001
36
Mutations in the thrombopoietin receptor, Mpl, in children with congenital amegakaryocytic thrombocytopenia. (10971406)
2000
37
Sustained response to combination therapy in a patient with chronic hepatitis C and thrombocytopenia secondary to alpha-interferon. (10847447)
2000
38
Further examination of various administration protocols of pegylated recombinant human megakaryocyte growth and development factor on thrombocytopenia in myelosuppressed mice. (10227790)
1998
39
Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production. (8896400)
1996
40
Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia. (8826901)
1996
41
Osteopetrosis, anemia, thrombocytopenia, and marrow necrosis in beef calves naturally infected with bovine virus diarrhea virus. (8580185)
1995
42
Heparin-induced thrombocytopenia and thrombosis. (9372019)
1995
43
A case of common variable immunodeficiency associated with cyclic thrombocytopenia. (7871984)
1994
44
Dengue virus and endothelial cell: a related phenomenon to thrombocytopenia and granulocytopenia in dengue hemorrhagic fever. (7886587)
1993
45
The effect of a single course of alpha-2B-interferon in patients with HIV-related and chronic idiopathic immune thrombocytopenia. (8329555)
1993
46
Characterization of an antibody to the integrin beta 3 subunit (GP IIIa) from a patient with neonatal thrombocytopenia and an inherited deficiency of GP IIb-IIIa complexes in platelets (Glanzmann's thrombasthenia). (1633270)
1992
47
Plasma levels of endothelial-derived haemostatic factors in autoimmune thrombocytopenia and haemolytic anaemia. (2119418)
1990
48
Splenectomy for thrombocytopenia due to secondary hypersplenism. (3422554)
1988
49
Quinidine leukopenia and thrombocytopenia with a drug-dependent leukoagglutinin. (836544)
1977
50
Congenital lipomatosis of the pancreas. Malabsorption, dwarfism, leukopenia with relative granulocytopenia and thrombocytopenia. (5665293)
1968

Variations for Thrombocytopenia

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Expression for genes affiliated with Thrombocytopenia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thrombocytopenia

Search GEO for disease gene expression data for Thrombocytopenia.

Pathways for genes affiliated with Thrombocytopenia

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Sources:
51PathCards, 55R&D Systems, 56Reactome, 5Cell Signaling Technology, 61Thomson Reuters, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 52PharmGKB
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Pathways related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ITGA2, ITGA2B
29.7GP1BA, ITGA2
3
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.6MPL, THPO
49.4CYCS, ITGA2B, ITGA2
5
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility61
Cytoskeleton remodeling Integrin outside in signaling61
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases61
Cell adhesion Tight junctions61
Development MAG dependent inhibition of neurite outgrowth61
9.4ITGA2, ITGB3, WAS
69.3ITGA2B, ITGB3
79.3ITGA2B, ITGB3
89.3ITGA2B, ITGB3
99.0ITGB3, ITGA2B, ITGA2
10
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
9.0ITGA2, ITGA2B, ITGB3
119.0ITGA2, ITGA2B, ITGB3
129.0ITGA2, ITGA2B, ITGB3
139.0ITGB3, ITGA2B, ITGA2
14
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
9.0ITGB3, ITGA2B, ITGA2
159.0ITGA2, ITGA2B, ITGB3
16
Show member pathways
8.8WAS, ITGB3, ITGA2B, ITGA2
17
Show member pathways
8.8ITGA2, ITGA2B, ITGB3, WAS
18
Show member pathways
8.8ITGA2, ITGA2B, ITGB3, WAS
19
Show member pathways
8.8ITGA2, ITGA2B, ITGB3, WAS
20
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
8.5GP1BA, ITGB3, ITGA2B, ITGA2
21
Show member pathways
8.5CYCS, ITGB3, ITGA2B, ITGA2, GATA1
228.2ITGB3, ITGA2B, ITGA2, IL3
23
Show member pathways
7.9THPO, GP1BA, MPL, ITGB3, ITGA2B
24
Show member pathways
7.8THPO, ITGB3, ITGA2B, ITGA2, IL3
25
Show member pathways
7.8IL3, ITGA2, ITGA2B, ITGB3, THPO
26
Show member pathways
7.6THPO, WAS, ITGB3, ITGA2B, ITGA2, IL3
27
Show member pathways
7.5THPO, CYCS, ITGB3, ITGA2B, ITGA2, IL3
28
Show member pathways
7.5THPO, CYCS, ITGB3, ITGA2B, ITGA2, IL3
29
Show member pathways
7.4THPO, GP1BA, MPL, ITGB3, ITGA2B, ITGA2
30
Show member pathways
7.4THPO, MPL, ITGB3, ITGA2B, ITGA2, IL3
317.3IL3, ITGA2, ITGA2B, ITGB3, GP1BA, THPO

Compounds for genes affiliated with Thrombocytopenia

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 25HMDB, 30IUPHAR
See all sources

Compounds related to Thrombocytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1megapoietin4610.0MPL, THPO
2anagrelide46 1211.0THPO, MPL
3aebsf469.9CFI, CYCS
4convulxin469.9ITGA2, GP1BA
5aclarubicin469.7IL3, GATA1
6obtustatin629.7ITGB3, ITGA2B
7a 286982629.7ITGB3, ITGA2B
8bio 1211629.7ITGB3, ITGA2B
9leukadherin 1629.7ITGB3, ITGA2B
10tc-i 15629.7ITGB3, ITGA2B
11homoharringtonine46 52 1211.7CYCS, IL3
12mafosfamide469.6THPO, IL3
13pixy321469.6IL3, THPO
14thromboxane46 2510.5THPO, MPL, ITGA2, GATA1
15amifostine46 1210.5IL3, THPO
16tirofiban46 1210.5ITGA2, ITGA2B, ITGB3
17latex469.5THPO, GP1BA, WAS, ITGA2
18filgrastim46 1210.4IL3, THPO
19hydroxyurea46 52 1211.4GATA1, IL3, THPO
20cytarabine46 52 1211.3THPO, IL3, GATA1
21abciximab46 1210.2GP1BA, ITGB3, ITGA2B
22ristocetin469.2GP1BA, ITGB3
23gp 130469.1IL3, MPL, THPO
24proline469.1GP1BA, WAS, ITGB3, ITGA2
25phosphatidylcholine469.1IL3, ITGA2, CYCS
26actinomycin d469.1THPO, CYCS, IL3, GATA1
27iron46 2510.0THPO, MPL, ITGB3, GATA1
2812-o-tetradecanoylphorbol 13-acetate469.0ITGA2B, ITGA2, IL3, GATA1
29butyrate468.9THPO, CYCS, ITGA2, IL3, GATA1
30vegf468.8THPO, MPL, ITGB3, ITGA2, GATA1
31cycloheximide468.8GATA1, IL3, ITGA2, CYCS
32prostacyclin468.8THPO, GP1BA, IL3
33phosphatidylserine46 30 1210.7ITGB3, GP1BA, CYCS
34atp46 309.7THPO, CYCS, WAS, ITGB3, ITGA2, RBM8A
35lactate468.6THPO, CYCS, GP1BA, IL3
36aspirin46 52 30 2511.6THPO, GP1BA, MPL, ITGB3, ITGA2
37lysine468.6THPO, MPL, ITGB3, ITGA2B, ITGA2
38heparin46 30 25 1211.5THPO, CFI, GP1BA, ITGA2, IL3
39retinoic acid46 259.5THPO, CYCS, CFI, ITGA2, IL3, GATA1
40glucose468.4THPO, CFI, GP1BA, ITGB3, ITGA2
41estrogen468.2THPO, CFI, ITGB3, IL3, GATA1
42fibrinogen468.2THPO, CFI, GP1BA, ITGB3, ITGA2B, ITGA2
43phosphatidylinositol468.2IL3, ITGA2, WAS, MPL, GP1BA, THPO
44threonine468.1GP1BA, MPL, ITGB3, ITGA2, IL3
45calcium46 52 25 1210.8THPO, CFI, GP1BA, WAS, ITGB3, ITGA2B
46alanine467.8HOXA11, THPO, GP1BA, MPL, ITGB3, IL3
47adp46 30 259.6MASTL, THPO, GP1BA, MPL, WAS, ITGB3
48tyrosine467.5THPO, GP1BA, MPL, WAS, ITGB3, ITGA2
49cysteine467.5THPO, CYCS, MPL, ITGB3, ITGA2B, ITGA2
50serine466.8CYCS, CFI, GP1BA, MPL, WAS, ITGB3

GO Terms for genes affiliated with Thrombocytopenia

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Sources:
17Gene Ontology
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Cellular components related to Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1focal adhesionGO:0059259.0ITGA2, ITGA2B, ITGB3
2platelet alpha granule membraneGO:0310929.0ITGA2B, ITGB3
3integrin complexGO:0083059.0ITGA2, ITGA2B, ITGB3

Biological processes related to Thrombocytopenia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of leukocyte migrationGO:0026879.6ITGA2B, ITGA2
2embryonic hemopoiesisGO:0351629.4GATA1, IL3
3platelet aggregationGO:0705279.2GATA1, ITGA2B, ITGB3
4integrin-mediated signaling pathwayGO:0072299.1ITGB3, ITGA2B, ITGA2
5cell-matrix adhesionGO:0071609.1ITGA2, ITGA2B, ITGB3
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.9ITGB3, IL3, GATA1
7cell adhesionGO:0071558.2ITGA2, ITGA2B, ITGB3, GP1BA
8platelet activationGO:0301688.1THPO, GP1BA, MPL, ITGB3, ITGA2B
9blood coagulationGO:0075967.4GATA1, THPO, GP1BA, MPL, WAS, ITGB3

Products for genes affiliated with Thrombocytopenia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thrombocytopenia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet