MCID: THR014
MIFTS: 63

Thrombocytopenia

Categories: Blood diseases, Genetic diseases, Rare diseases, Immune diseases

Aliases & Classifications for Thrombocytopenia

Summaries for Thrombocytopenia

Disease Ontology : 12 A blood platelet disease characterized by low a platelet count in the blood.

MalaCards based summary : Thrombocytopenia is related to thrombocytopenia-absent radius syndrome and thrombocytopenic purpura, autoimmune. An important gene associated with Thrombocytopenia is ETV6 (ETS Variant 6), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Actin Nucleation by ARP-WASP Complex. The drugs Dimethyl sulfoxide and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and myeloid, and related phenotypes are cellular and hematopoietic system

Wikipedia : 72 Thrombocytopenia is a condition characterized by abnormally low levels of thrombocytes, also known as... more...

Related Diseases for Thrombocytopenia

Diseases in the Thrombocytopenia family:

Thrombocytopenia 3 Thrombocytopenia 4
Thrombocytopenia 2 Thrombocytopenia 5
Thrombocytopenia 6 Acquired Thrombocytopenia
Thrombocytopenia Due to Platelet Alloimmunization Primary Thrombocytopenia
Myh9 Related Thrombocytopenia Mastl-Related Thrombocytopenia 2
Gata1-Related Thrombocytopenia

Diseases related to Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 598)
id Related Disease Score Top Affiliating Genes
1 thrombocytopenia-absent radius syndrome 34.3 ANKRD26 GATA1 GP1BA MPL
2 thrombocytopenic purpura, autoimmune 32.0 GP1BA IL11 ITGA2B ITGB3 MPL
3 hemolytic anemia 30.7 CYCS ETV6 MECOM MPL
4 pseudo-torch syndrome 2 30.5 GP1BA GP1BB GP9
5 hepatosplenic t-cell lymphoma 30.2 ETV6 GATA1
6 bleeding disorder, platelet-type, 16, autosomal dominant 29.2 GP1BA GP9 ITGA2 ITGA2B ITGB3
7 essential thrombocythemia 29.1 GP1BA GP9 ITGA2B ITGB3
8 myocardial infarction 29.1 ADAMTS13 GP1BA ITGA2 ITGA2B ITGB3
9 myeloproliferative neoplasm 26.9 ADAMTS13 GP1BA GP1BB GP9 ITGA2B ITGB3
10 heparin-induced thrombocytopenia 12.3
11 thrombocytopenia, x-linked 12.3
12 thrombocytopenia, congenital amegakaryocytic 12.2
13 fetal and neonatal alloimmune thrombocytopenia 12.1
14 thrombocytopenia with beta-thalassemia, x-linked 12.1
15 thrombocytopenia, paris-trousseau type 12.1
16 dyserythropoietic anemia and thrombocytopenia 12.1
17 hemangioma-thrombocytopenia syndrome 12.1
18 thrombocytopenia, x-linked, with or without dyserythropoietic anemia 12.1
19 thrombocytopenia due to platelet alloimmunization 12.0
20 thrombocytopenia 5 12.0
21 acquired amegakaryocytic thrombocytopenia 12.0
22 thrombocytopenia 2 12.0
23 acquired thrombocytopenia 12.0
24 radioulnar synostosis with amegakaryocytic thrombocytopenia 1 12.0
25 thrombocytopenia 4 12.0
26 radioulnar synostosis with amegakaryocytic thrombocytopenia 2 12.0
27 thrombocytopenia 6 12.0
28 thrombocytopenia 3 11.9
29 thrombocytopenia, anemia, and myelofibrosis 11.9
30 primary thrombocytopenia 11.9
31 radioulnar synostosis with amegakaryocytic thrombocytopenia 11.9
32 thrombocytopenia, neonatal alloimmune 11.9
33 myh9 related thrombocytopenia 11.9
34 multifocal lymphangioendotheliomatosis with thrombocytopenia 11.8
35 cyclic thrombocytopenia 11.8
36 thrombocytopenia robin sequence 11.8
37 transient neonatal thrombocytopenia 11.8
38 hereditary thrombocytopenia with normal platelets 11.7
39 autosomal thrombocytopenia with normal platelets 11.7
40 wiskott-aldrich syndrome 11.7
41 thrombocytopenia with or without dyserythropoietic anemia 11.7
42 gata1-related anemia with thrombocytopenia 11.6
43 gata1-related thrombocytopenia with beta-thalassemia 11.6
44 mastl-related thrombocytopenia 2 11.6
45 thrombocytopenia cerebellar hypoplasia short stature 11.6
46 thrombocytopenia with elevated serum iga and renal disease 11.6
47 gata1-related thrombocytopenia 11.6
48 autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome 11.6
49 familial thrombotic thrombocytopenia purpura 11.6
50 skeleto cardiac syndrome with thrombocytopenia 11.6

Graphical network of the top 20 diseases related to Thrombocytopenia:



Diseases related to Thrombocytopenia

Symptoms & Phenotypes for Thrombocytopenia

MGI Mouse Phenotypes related to Thrombocytopenia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.17 CYCS ETV6 GATA1 GP1BA HOXA11 ITGA2
2 hematopoietic system MP:0005397 10.03 SRC WAS ADAMTS13 CYCS ETV6 GATA1
3 embryo MP:0005380 9.96 CYCS ETV6 GATA1 ITGA2B ITGB3 MASTL
4 homeostasis/metabolism MP:0005376 9.77 GATA1 GP1BA GP1BB ITGA2 ITGA2B ITGB3
5 immune system MP:0005387 9.36 ADAMTS13 CYCS ETV6 GATA1 ITGA2B ITGB3

Drugs & Therapeutics for Thrombocytopenia

Drugs for Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 487)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dimethyl sulfoxide Approved, Vet_approved Phase 4,Phase 1 67-68-5 679
2
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
3
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
4
Gemcitabine Approved Phase 4,Phase 2,Phase 1 95058-81-4 60750
5
Oprelvekin Approved, Investigational Phase 4,Phase 2,Phase 3 145941-26-0
6 Certoparin Approved Phase 4,Phase 3
7
Dalteparin Approved Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6
8
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
9
Bivalirudin Approved, Investigational Phase 4,Phase 3 128270-60-0 16129704
10
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
11
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
12
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
13
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
14
Idarubicin Approved Phase 4,Phase 3,Phase 2 58957-92-9 42890
15
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
16
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
17
Ribavirin Approved Phase 4,Phase 2,Phase 3 36791-04-5 37542
18
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
19
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
20
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
21
Dexlansoprazole Approved Phase 4,Phase 2 138530-94-6, 103577-45-3 9578005
22
Lansoprazole Approved, Investigational Phase 4,Phase 2 103577-45-3 3883
23
alemtuzumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 216503-57-0
24
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666
25
Fludarabine Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 21679-14-1, 75607-67-9 30751
26
Vidarabine Approved Phase 4,Phase 3,Phase 2 24356-66-9 32326 21704
27
Argatroban Approved, Investigational Phase 4,Phase 3,Phase 2 74863-84-6 152951
28
Abciximab Approved Phase 4,Phase 3 143653-53-6
29 Nadroparin Approved Phase 4 9041-08-1
30
Fluorouracil Approved Phase 4,Phase 3,Phase 2 51-21-8 3385
31
Oxaliplatin Approved, Investigational Phase 4,Phase 2 61825-94-3 5310940 9887054 43805 6857599
32
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
33
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
34
Ticlopidine Approved Phase 4 55142-85-3 5472
35
Desirudin Approved Phase 4,Phase 2,Phase 3 120993-53-5
36
Thrombin Approved Phase 4,Phase 3,Phase 2
37
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2 198153-51-4 5360545
38
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1 159351-69-6 6442177
39
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53123-88-9 5284616 6436030 46835353
40
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 104987-11-3 445643 439492
41
Azathioprine Approved Phase 4,Phase 3,Phase 1 446-86-6 2265
42
Hydroxychloroquine Approved Phase 4,Phase 3 118-42-3 3652
43
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
44
Lepirudin Approved Phase 4 120993-53-5, 138068-37-8 16132441
45
Warfarin Approved Phase 4,Phase 3,Phase 2 81-81-2 6691 54678486
46
Abatacept Approved Phase 4 332348-12-6 10237
47
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
48
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2 58-05-9 143 6006
49 Fondaparinux Investigational Phase 4,Phase 3,Phase 2,Phase 1 104993-28-4
50
Caffeic acid Experimental Phase 4,Phase 3 331-39-5 1549111

Interventional clinical trials:

(show top 50) (show all 793)

id Name Status NCT ID Phase Drugs
1 Protocol for the Infusion of Buffy Coat-derived Cryopreserved Platelets in Patients With Severe Thrombocytopenia Unknown status NCT02032134 Phase 4
2 The Study of rHuTPO/rHuIL-11 in the Treatment for Chemotherapy-induced Thrombocytopenia in Patients With NSCLC Unknown status NCT02344979 Phase 4
3 The HIT-TRAP Trial Unknown status NCT00196417 Phase 4 Standard heparin (UFH) versus certoparin (LMWH)
4 Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients Unknown status NCT02355873 Phase 4
5 Efficacy and Safety of rHuTPO on Platelet Engraftment After Allo-HSCT Unknown status NCT01379391 Phase 4 Recombinant Human Thrombopoietin (rHTPO)
6 Comparing Bivalirudin Versus Heparin/ GP IIB/IIA in Patients Undergoing PCI Unknown status NCT00476944 Phase 4
7 Impact of Heparin on the Need for Mechanical Ventilation in Neonates Unknown status NCT00196469 Phase 4 heparin
8 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
9 The Study of Different Dose Rituximab in the Treatment of ITP Completed NCT03258866 Phase 4 Rituximab;Rituximab
10 Bivalirudin PCI Registry in Heparin Induced Thrombocytopenia/Heparin Induced Thrombocytopenia and Thrombosis Syndrome (HIT/HITTS) Patients Completed NCT00759083 Phase 4 bivalirudin
11 A Study to Confirm the Efficacy and Safety of Fludarabine Phosphate Administered in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia Completed NCT00220311 Phase 4 Fludarabine Phosphate (Fludara)
12 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
13 Evaluation of Argatroban Injection in Pediatric Patients Requiring Anticoagulant Alternatives to Heparin Completed NCT00039858 Phase 4 Argatroban
14 High-dose Dexamethasone Versus Conventional Dose Prednisone for Initial Treatment of Primary Immune Thrombocytopenia (ITP) Completed NCT01356511 Phase 4 Prednisone;Dexamethasone
15 Study to Reveal if Fibrinogen Treatment Effects Blood Clotting Better Than a Platelet Transfusion Completed NCT01955811 Phase 4 Administration of platelet concentrate and taking blood samples
16 Evaluation of the Efficacy of Platelets Treated With Pathogen Reduction Process Completed NCT01789762 Phase 4
17 EArly Discharge After Transradial Stenting of CoronarY Arteries: The EASY Study Completed NCT00169819 Phase 4 Abciximab
18 Enoxaparin Versus Unfractionated Heparin in PCI Completed NCT00439855 Phase 4 Enoxaparin i.v.;unfractionated heparin
19 Nadroparin for the Initial Treatment of Pulmonary Thromboembolism Completed NCT00796692 Phase 4 Nadroparin;Unfractionated heparin(UFH)
20 Value of Abciximab in Patients With AMI Undergoing Primary PCI After Clopidogrel Pretreatment (BRAVE 3) Completed NCT00133250 Phase 4 Abciximab
21 Venous Thromboembolic Prophylaxis After Trauma: Three Times a Day Unfractionated Heparin Versus Twice a Day Enoxaparin Completed NCT01729559 Phase 4 5000 Units unfractionated Heparin Q 8 hr;30mg enoxaparin Q12 hr
22 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
23 Study to Evaluate the Mortality Reduction of Enoxaparin in Hospitalized Acutely Ill Medical Receiving Enoxaparin Completed NCT00622648 Phase 4 Enoxaparin;Placebo
24 EXCLAIM:Extended Prophylaxis for Venous ThromboEmbolism (VTE) in Acutely Ill Medical Patients With Prolonged Immobilization Completed NCT00077753 Phase 4 enoxaparin sodium
25 Intensified Dosing of Cellcept (Mycophenolate Mofetil) in Kidney Transplantation Completed NCT00943228 Phase 4 mycophenolate mofetil
26 SMD_FLAG-IDA_98: FLAG-IDA in Induction Treatment of High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia Completed NCT00487448 Phase 4 Fludarabine;Cytarabine;G-CSF;Idarubicin
27 Platelet Function in Idiopathic Thrombocytopenic Purpura (ITP) Patients With Eltrombopag Completed NCT00888901 Phase 4 eltrombopag;corticosteroids (Aprednislon)
28 Efficacy of Abciximab Bolus Only Regimen in Providing Inhibition of Platelet Action Over Time Completed NCT00929279 Phase 4 bolus+infusion;abciximab bolus only regimen
29 Safety Study of Stopping Thromboprophylaxis Based on Ultrasound Results After Total Knee Replacement Completed NCT00362492 Phase 4
30 Safety Study of Desirudin, an Anticoagulant for the Prophylaxis of Thrombosis Completed NCT00913133 Phase 4 Desirudin
31 A Study of The Relationship Between Drop in Hemoglobin and Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Copegus (Ribavirin) and Pegasys (Peginterferon Alfa-2a) Completed NCT01585324 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin [Copegus]
32 How Effective Are Antithrombotic Therapies in Primary Percutaneous Coronary Intervention Completed NCT01519518 Phase 4 unfractionated heparin;Bivalirudin
33 Study Evaluating A Planned Transition From Tacrolimus To Sirolimus In Kidney Transplant Recipients Completed NCT00895583 Phase 4 Tacrolimus;Sirolimus;Tacrolimus
34 A Safety Study of Intravenous Immunoglobulin in Patients With Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT01390649 Phase 4
35 A Longitudinal 2-year Bone Marrow Study of Eltrombopag in Previously Treated Adults, With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT01098487 Phase 4 Eltrombopag olamine
36 Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura Completed NCT00467571 Phase 4 lansoprazole, clarithromycin, amoxycillin
37 The Efficacy and Safety of Huaiqihuang Granule in Children With Chronic Primary Immune Thrombocytopenia Recruiting NCT03201848 Phase 4 Placebo;Huaiqihuang Granule
38 Efficacy and Safety of rhTPO for the Treatment of Thrombocytopenia After Chemotherapy in AML Patients Recruiting NCT02267993 Phase 4 recombinant human thrombopoietin
39 Caffeic Acid Combining High-dose Dexamethasone in Management of ITP Recruiting NCT02556814 Phase 4 Caffeic acid tablets;Dexamethasone;placebo
40 Immunomodulation With Romiplostim in Young Adults With ITP Recruiting NCT02760251 Phase 4 romiplostim
41 A Rollover Study to Provide Continued Treatment With Eltrombopag Recruiting NCT01957176 Phase 4 ELT
42 Rate of Prolonged Response After Stopping Thrombopoietin-receptor Agonists Treatment in ITP Recruiting NCT03119974 Phase 4 Tpo-RA discontinuation
43 A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab) Recruiting NCT01734382 Phase 4 Tocilizumab
44 Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction Recruiting NCT01935128 Phase 4 Arm 1 Everolimus/Reduced dose tacrolimus
45 Study Assessing an Algorithm-based Strategy of Eculizumab Discontinuation in Children and Adults With aHUS Recruiting NCT02574403 Phase 4 eculizumab
46 Thromboprophylaxis of Venous Thromboembolism in Acutely-ill Medical Inpatients With Thrombocytopenia Active, not recruiting NCT01727401 Phase 4 Fondaparinux
47 Eval. of Potential Predictors of Disease Progression in Patients With aHUS Including Genetics, Biomarkers and Treatment Enrolling by invitation NCT02614898 Phase 4
48 Reposition of Second Line Treatment in Chronic Immune Thrombocytopenia Not yet recruiting NCT03229746 Phase 4 Hydroxychloroquine;vincristine;azathioprine
49 Effects of Helicobacter Pylori Eradication in Children With Chronic Immune Thrombocytopenic Purpura Not yet recruiting NCT03172676 Phase 4 Amoxicillin 50 mg/kg/day in 2 divided doses for 14 days.;Clarithromycin 15 mg/kg/day in 2 divided doses for 14 days.;Proton pump inhibitor 1 mg/kg/day in 2 divided doses 1 month
50 Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders Not yet recruiting NCT03227419 Phase 4 Tocilizumab Prefilled Syringe;Abatacept Prefilled Syringe

Search NIH Clinical Center for Thrombocytopenia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Thrombocytopenia cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: thrombocytopenia

Genetic Tests for Thrombocytopenia

Genetic tests related to Thrombocytopenia:

id Genetic test Affiliating Genes
1 Thrombocytopenia 29

Anatomical Context for Thrombocytopenia

MalaCards organs/tissues related to Thrombocytopenia:

39
Liver, Bone, Myeloid, Bone Marrow, Testes, Lung, Kidney

Publications for Thrombocytopenia

Articles related to Thrombocytopenia:

(show top 50) (show all 2705)
id Title Authors Year
1
Postdiarrhoeal haemolytic uraemic syndrome without thrombocytopenia. ( 28946963 )
2017
2
Paroxysmal Nocturnal Hemoglobinuria in the Differential Diagnosis of Thrombocytopenia. ( 28435653 )
2017
3
The Role of Apixaban in the Treatment of Heparin-Induced Thrombocytopenia. ( 28884054 )
2017
4
Hydrophilic Polymer Embolism in the Lung as an Adverse Eventa88- Autopsy Case of Thromboembolisms in Multiple Organs Associated With Heparin-Induced Thrombocytopenia. ( 28626145 )
2017
5
From chronic immune thrombocytopenia to severe aplastic anemia: recent insights into the evolution of eltrombopag. ( 28473904 )
2017
6
MYH9-Related Thrombocytopenia. ( 28688473 )
2017
7
The Amelioration of Myelofibrosis with Thrombocytopenia by a JAK1/2 Inhibitor, Ruxolitinib, in a Post-polycythemia Vera Myelofibrosis Patient with a JAK2 Exon 12 Mutation. ( 28674362 )
2017
8
Two Cases of Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome with High Serum Procalcitonin Levels, Including the First Case Complicated with Adrenal Hemorrhaging. ( 28502946 )
2017
9
Infections in non-splenectomized persistent or chronic primary immune thrombocytopenia adults: risk factors and vaccination effect. ( 28078756 )
2017
10
Severe fever with thrombocytopenia syndrome virus inhibits exogenous Type I IFN signaling pathway through its NSs invitro. ( 28234991 )
2017
11
Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis. ( 28296884 )
2017
12
Delayed Appearance of Cutaneous Lesions of Cutaneovisceral Angiomatosis (CAT) Leading to Misdiagnosis of Immune Thrombocytopenia. ( 28234740 )
2017
13
Persistent symptomatic parvovirus B19 infection with severe thrombocytopenia transmitted by red blood cell transfusion containing low parvovirus B19 DNA levels. ( 28369973 )
2017
14
Antenatal management in fetal and neonatal alloimmune thrombocytopenia: a systematic review. ( 28130210 )
2017
15
Adult-onset, chronic, cyclic thrombocytopenia in a Rhesus macaque (Macaca mulatta) after dengue virus vaccination and viral challenge. ( 28518476 )
2017
16
Effectiveness of a Laboratory Gate-Keeping Strategy to Overcome Inappropriate Test Utilization for the Diagnosis of Heparin-Induced Thrombocytopenia. ( 28750423 )
2017
17
Serum Thymidine Kinase 1, Canine-C-Reactive Protein, Haptoglobin, and Vitamin D Concentrations in Dogs with Immune-Mediated Hemolytic Anemia, Thrombocytopenia, and Polyarthropathy. ( 28804921 )
2017
18
Maternal HLA genotyping is not useful for predicting severity of fetal and neonatal alloimmune thrombocytopenia. ( 27748520 )
2017
19
Autoimmune heparin-induced thrombocytopenia. ( 28846826 )
2017
20
Differential diagnosis of neonatal alloimmune thrombocytopenia: Type 2B von Willebrand disease. ( 28436749 )
2017
21
Immune Thrombocytopenia Induced by Nivolumab in a Metastatic Non-Small Cell Lung Cancer Patient. ( 28950270 )
2017
22
Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1. ( 27994071 )
2017
23
NSs protein of severe fever with thrombocytopenia syndrome virus suppresses interferon production through different mechanism than Rift Valley fever virus. ( 28854793 )
2017
24
Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome. ( 28086978 )
2017
25
Extensive Intracardiac and Deep Venous Thromboses in a Young Woman with Heparin-Induced Thrombocytopenia and May-Thurner Syndrome. ( 28465848 )
2017
26
FC gamma receptor polymorphisms in patients with immune thrombocytopenia. ( 28942727 )
2017
27
The Clinical Utility of the Heparin Neutralization Assay in the Diagnosis of Heparin-Induced Thrombocytopenia. ( 28774196 )
2017
28
Novel G6B gene variant causes familial autosomal recessive thrombocytopenia and anemia. ( 27743390 )
2017
29
Efficacy of Repeated Lusutrombopag Administration for Thrombocytopenia in a Patient Scheduled for Invasive Hepatocellular Carcinoma Treatment. ( 28943563 )
2017
30
The first reported case of concurrent trimethoprim-sulfamethoxazole-induced immune hemolytic anemia and thrombocytopenia. ( 28905389 )
2017
31
Erratum: Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia. ( 28240280 )
2017
32
Direct acting oral anticoagulants for the treatment of suspected heparin-induced thrombocytopenia. ( 28672052 )
2017
33
Etiology and complications of thrombocytopenia in hospitalized medical patients. ( 28054307 )
2017
34
Is oral all-trans retinoic acid plus danazol a refinement of second-line therapy for primary immune thrombocytopenia in adults? ( 28917656 )
2017
35
Re: Severe Primary Autoimmune Thrombocytopenia (ITP) in Pregnancy: a national cohort study Primary immune thrombocytopenia management during pregnancy. A French study. ( 28940981 )
2017
36
Association Between TNF-I+ -308G/A Polymorphism and Risk of Immune Thrombocytopenia: A Meta-Analysis. ( 27960071 )
2017
37
Commentary: Carotid Endarterectomy in Patients With Thrombocytopenia: Analysis of National Surgical Quality Improvement Program Registry. ( 28931263 )
2017
38
Authors' reply re: Severe Primary Autoimmune Thrombocytopenia (ITP) in Pregnancy: a national cohort study. ( 28940966 )
2017
39
FcI^ receptor expression on splenic macrophages in adult immune thrombocytopenia. ( 28142207 )
2017
40
A Right hepatic lobe resection and thrombocytopenia. ( 28051788 )
2017
41
Intermittent low platelet counts hampering diagnosis of X-linked thrombocytopenia in children: report of two unrelated cases and a novel mutation in the gene coding for the Wiskott-Aldrich syndrome protein. ( 28641574 )
2017
42
Oral all-trans retinoic acid plus danazol versus danazol as second-line treatment in adults with primary immune thrombocytopenia: a multicentre, randomised, open-label, phase 2 trial. ( 28917657 )
2017
43
Refractory primary immune thrombocytopenia with subsequent del(5q) MDS: complete remission of both after lenalidomide. ( 28052942 )
2017
44
Persistent Heparin-Induced Thrombocytopenia Treated With IVIg. ( 28889885 )
2017
45
Fetal and neonatal alloimmune thrombocytopenia: evidence based antenatal and postnatal management strategies. ( 28644735 )
2017
46
A neutralization assay with a severe fever with thrombocytopenia syndrome virus strain that makes plaques in inoculated cells. ( 28082164 )
2017
47
Babesiosis-associated immune thrombocytopenia. ( 28217703 )
2017
48
Decreased function of Fas and variations of the perforin gene in adult patients with primary immune thrombocytopenia. ( 27391055 )
2017
49
Immune thrombocytopenia of childhood responsive to tonsillectomy in the setting of chronic tonsillitis: A case report and literature review. ( 28648251 )
2017
50
Is low serum albumin level a significant predictor for the development of heparin-induced thrombocytopenia-thrombosis? ( 28289828 )
2017

Variations for Thrombocytopenia

ClinVar genetic disease variations for Thrombocytopenia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 ETV6 NM_001987.4(ETV6): c.641C> T (p.Pro214Leu) single nucleotide variant Pathogenic/Likely pathogenic rs724159947 GRCh38 Chromosome 12, 11869601: 11869601
2 ETV6 NM_001987.4(ETV6): c.1106G> A (p.Arg369Gln) single nucleotide variant Pathogenic rs724159946 GRCh38 Chromosome 12, 11884541: 11884541
3 ETV6 NM_001987.4(ETV6): c.1195C> T (p.Arg399Cys) single nucleotide variant Pathogenic rs724159945 GRCh37 Chromosome 12, 12038902: 12038902
4 ETV6 NM_001987.4(ETV6): c.1153-5_1153-1delAACAG deletion Pathogenic rs786205154 GRCh37 Chromosome 12, 12038855: 12038859
5 ETV6 NM_001987.4(ETV6): c.1046T> C (p.Leu349Pro) single nucleotide variant Pathogenic rs786205155 GRCh37 Chromosome 12, 12037415: 12037415

Expression for Thrombocytopenia

Search GEO for disease gene expression data for Thrombocytopenia.

Pathways for Thrombocytopenia

Pathways related to Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 27)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 GATA1 GP1BA GP1BB GP9 ITGA2 ITGA2B
2
Show member pathways
12.91 ITGA2 ITGA2B ITGB3 MYH9 SRC WAS
3
Show member pathways
12.83 ITGA2 ITGA2B ITGB3 MYH9 SRC WAS
4
Show member pathways
12.77 IL11 ITGA2 ITGA2B ITGB3 SRC
5
Show member pathways
12.76 CYCS ITGA2 ITGA2B ITGB3 SRC
6
Show member pathways
12.55 ITGA2 ITGB3 MYH9 SRC WAS
7 12.53 ITGA2 ITGA2B ITGB3 MYH9 SRC WAS
8
Show member pathways
12.32 ITGA2 ITGA2B ITGB3 SRC
9
Show member pathways
12.14 ITGA2 ITGA2B ITGB3 SRC
10
Show member pathways
12.09 GP1BA GP1BB GP9 ITGA2 ITGA2B ITGB3
11
Show member pathways
11.93 ITGA2 ITGA2B ITGB3 SRC
12 11.91 GP1BA IL11 ITGA2 ITGA2B ITGB3 MPL
13 11.85 ITGA2 ITGA2B ITGB3 SRC
14 11.79 GP1BA GP1BB GP9 ITGA2 ITGA2B ITGB3
15 11.72 CYCS ITGA2 ITGA2B
16 11.72 ITGA2 ITGA2B ITGB3
17 11.52 ITGA2 ITGA2B ITGB3
18 11.51 GP1BB GP9 ITGA2 ITGA2B ITGB3
19
Show member pathways
11.49 GP1BA GP1BB GP9 ITGA2B ITGB3 MPL
20 11.45 ITGA2B ITGB3 SRC
21 11.44 GATA1 GP9 ITGA2B ITGB3
22 11.38 IL11 ITGA2 SRC
23 11.23 ITGA2B ITGB3 SRC
24 11.15 GP1BA GP1BB GP9 IL11 ITGA2 ITGA2B
25 11.12 ITGA2B ITGB3 SRC
26 10.74 GP1BA GP1BB GP9 ITGA2
27 10.56 GP1BA GP1BB GP9 SRC

GO Terms for Thrombocytopenia

Cellular components related to Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.43 ADAMTS13 GP1BA ITGA2 ITGA2B ITGB3 MPL
2 platelet alpha granule membrane GO:0031092 9.16 ITGA2B ITGB3
3 integrin complex GO:0008305 8.92 ITGA2 ITGA2B ITGB3 MYH9

Biological processes related to Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.92 GP1BA GP1BB GP9 ITGA2 ITGA2B ITGB3
2 cell-matrix adhesion GO:0007160 9.76 ADAMTS13 ITGA2 ITGA2B ITGB3
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.73 GATA1 IL11 ITGB3 SRC
4 platelet activation GO:0030168 9.73 ADAMTS13 GP1BA GP1BB GP9 ITGB3 SRC
5 hemostasis GO:0007599 9.67 ADAMTS13 GP1BA GP1BB GP9
6 positive regulation of smooth muscle cell migration GO:0014911 9.6 ITGA2 SRC
7 platelet formation GO:0030220 9.59 GATA1 MYH9
8 cell-substrate adhesion GO:0031589 9.58 ITGA2 ITGB3
9 cell adhesion mediated by integrin GO:0033627 9.58 ITGA2 ITGB3
10 blood coagulation, intrinsic pathway GO:0007597 9.58 GP1BA GP1BB GP9
11 uterus development GO:0060065 9.57 HOXA11 SRC
12 actin filament-based movement GO:0030048 9.56 MYH9 WAS
13 hematopoietic stem cell proliferation GO:0071425 9.55 ETV6 MECOM
14 platelet aggregation GO:0070527 9.55 GATA1 GP1BA ITGA2B ITGB3 MYH9
15 positive regulation of leukocyte migration GO:0002687 9.54 ITGA2 ITGA2B
16 mesodermal cell differentiation GO:0048333 9.52 ITGA2 ITGB3
17 response to amine GO:0014075 9.51 ADAMTS13 ITGA2
18 regulation of bone resorption GO:0045124 9.49 ITGB3 SRC
19 megakaryocyte differentiation GO:0030219 9.48 GATA1 IL11
20 integrin-mediated signaling pathway GO:0007229 9.43 ADAMTS13 ITGA2 ITGA2B ITGB3 MYH9 SRC
21 blood coagulation GO:0007596 9.23 ADAMTS13 GATA1 GP1BA GP1BB GP9 ITGA2

Molecular functions related to Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.53 ADAMTS13 CYCS ETV6 GATA1 GP1BA GP1BB
2 integrin binding GO:0005178 9.13 ADAMTS13 ITGA2 SRC

Sources for Thrombocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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