MCID: THR014
MIFTS: 56

Thrombocytopenia malady

Genetic diseases, Blood diseases, Rare diseases, Immune diseases categories

Aliases & Classifications for Thrombocytopenia

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Thrombocytopenia, Aliases & Descriptions:

Name: Thrombocytopenia 30 9 11 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


External Ids:

Disease Ontology9 DOID:1588
ICD9CM27 287.5
NCIt38 C3408
MeSH33 D013921

Summaries for Thrombocytopenia

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Wikipedia:63 The terms thrombocytopenia and thrombopenia refer to a disorder in which there is a relative decrease of... more...

MalaCards based summary: Thrombocytopenia is related to thrombocytopenia-absent radius syndrome and purpura. An important gene associated with Thrombocytopenia is WAS (Wiskott-Aldrich syndrome), and among its related pathways are Articular Cartilage Extracellular Matrix and Platelet Adhesion to exposed collagen. The compounds megapoietin and anagrelide have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related mouse phenotypes are embryogenesis and renal/urinary system.

Disease Ontology:9 A blood platelet disease characterized by low a platelet count in the blood.

Related Diseases for Thrombocytopenia

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Diseases in the Thrombocytopenia family:

Thrombocytopenia 4 Thrombocytopenia 2
Thrombocytopenia 5 Thrombocytopenia Due to Platelet Alloimmunization
Acquired Thrombocytopenia Myh9 Related Thrombocytopenia
Mastl-Related Thrombocytopenia 2 Ankrd26-Related Thrombocytopenia 2
Gata1-Related Thrombocytopenia

Diseases related to Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 658)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia-absent radius syndrome31.6THPO
2purpura31.6THPO
3thrombocytopenia, x-linked31.2WAS, THPO, GATA1
4wiskott-aldrich syndrome31.2GATA1, WAS, THPO
5thrombocytopenia 231.1ANKRD26
6gray platelet syndrome31.0GATA1
7splenomegaly30.7THPO, MPL
8thrombocytopenia, congenital amegakaryocytic30.6IL3, MPL, THPO
9myelofibrosis30.6MPL, THPO
10von willebrand's disease30.5GP1BA, ITGA2B
11thrombocytopenia due to platelet alloimmunization30.5ITGA2B, MPL, THPO
12coronary thrombosis30.3ITGB3
13neutropenia30.3WAS, IL3, MPL, THPO
14thrombocytopenic purpura, autoimmune30.0GP1BA, MPL, THPO, ITGB3
15thrombocytosis30.0THPO, GP1BA, MPL, IL3
16liver cirrhosis29.9ITGB3, THPO, MPL
17pancytopenia29.9THPO, MPL, IL3
18breast cancer29.8GATA1, ITGA2, GP1BA, CYCS
19deficiency anemia29.8MPL, IL3, THPO, GATA1
20glanzmann thrombasthenia29.8ITGB3, ITGA2B
21myelodysplastic syndrome29.8GATA1, IL3, MPL, THPO, GP1BA
22myocardial infarction29.7ITGB3, GP1BA, CYCS, ITGA2B, ITGA2
23acute leukemia29.7THPO, GATA1, MPL, IL3
24severe congenital neutropenia29.7THPO, IL3
25polycythemia vera29.6IL3, ITGB3, MPL, THPO
26myeloid leukemia29.6THPO, GATA1, IL3, MPL, CFI, CYCS
27essential thrombocythemia29.6GATA1, IL3, MPL, THPO
28polycythemia29.5MPL, ITGB3, IL3, THPO
29aplastic anemia29.5IL3, THPO, MPL, GP1BA, GATA1
30bernard-soulier syndrome, type c29.4ITGA2, ITGA2B, ITGB3, GP1BA, THPO
31vascular disease29.4ITGA2, ITGB3, GP1BA
32leukemia29.4GATA1, MPL, ITGB3, ITGA2B, IL3, HOXA11
33rheumatoid arthritis29.4THPO, CFI, ITGA2, ITGB3
34heparin-induced thrombocytopenia11.2
35leukopenia10.6
36hepatitis10.6
37cyclic thrombocytopenia10.6
38hemolytic anemia10.5
39malaria10.5
40hepatitis c10.5
41hemangioma10.4
42hemangioma thrombocytopenia syndrome10.4
43systemic lupus erythematosus10.4
44lupus erythematosus10.4
45thrombocythemia 110.4THPO
46acquired thrombocytopenia10.4
47dyserythropoietic anemia and thrombocytopenia10.4
48hypersplenism10.4
49myh9 related thrombocytopenia10.4
50plasmodium vivax malaria10.4

Graphical network of the top 20 diseases related to Thrombocytopenia:



Diseases related to thrombocytopenia

Symptoms for Thrombocytopenia

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Drugs & Therapeutics for Thrombocytopenia

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Drug clinical trials:

Search ClinicalTrials for Thrombocytopenia

Search NIH Clinical Center for Thrombocytopenia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Thrombocytopenia cell therapies at LifeMap Discovery.

Genetic Tests for Thrombocytopenia

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Anatomical Context for Thrombocytopenia

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MalaCards organs/tissues related to Thrombocytopenia:

31
Liver, Bone, Testes, Bone marrow, T cells, Heart, Spleen, Skin, Myeloid, B cells, Kidney, Lung, Monocytes, Breast, Endothelial, Pituitary, Thyroid, Whole blood, Colon, Pancreas, Neutrophil, Lymph node, Ovary, Placenta, Prostate, Pineal

Animal Models for Thrombocytopenia or affiliated genes

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MGI Mouse Phenotypes related to Thrombocytopenia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.1GATA1, MASTL, ITGA2B, ITGB3, MPL, CYCS
2MP:00053677.8ANKRD26, HOXA11, CFI, WAS, ITGB3, IL3
3MP:00053876.6GATA1, IL3, ITGA2B, ITGB3, MPL, CYCS
4MP:00053766.2MPL, GP1BA, ANKRD26, WAS, ITGB3, ITGA2B
5MP:00053976.1GATA1, IL3, ITGA2, ITGA2B, ITGB3, WAS
6MP:00053846.1GATA1, HOXA11, CYCS, GP1BA, MPL, WAS

Publications for Thrombocytopenia

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Articles related to Thrombocytopenia:

(show top 50)    (show all 2263)
idTitleAuthorsYear
1
Vitamin B12 and vitamin d deficiencies: an unusual cause of Fever, severe hemolytic anemia and thrombocytopenia. (25811010)
2015
2
Heparin-induced thrombocytopenia. (25751293)
2015
3
Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia. (24438083)
2014
4
Dental procedures in 24 patients with chronic immune thrombocytopenia in prospective clinical studies of eltrombopag. (24433306)
2014
5
Therapeutic platelet transfusion for hypoproliferative thrombocytopenia - authors' reply. (23472916)
2013
6
Heparin-induced thrombocytopenia associated with thrombotic microangiopathy. (23715106)
2013
7
Argatroban in heparin-induced thrombocytopenia: rationale for use and place in therapy. (24179672)
2013
8
Oral eltrombopag for up to three years is safe and well-tolerated in Japanese patients with previously treated chronic immune thrombocytopenia: an open-label, extension study. (23896965)
2013
9
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
10
The I+IIb p.Leu841Met (Cab3(a+) ) polymorphism results in a new human platelet alloantigen involved in neonatal alloimmune thrombocytopenia. (22738334)
2013
11
A study of cytological changes in the bone marrow of patients with severe Fever with thrombocytopenia syndrome. (24349423)
2013
12
Rapidly Involuting Congenital Hemangioma Associated with Profound, Transient Thrombocytopenia. (22937785)
2012
13
Thrombocytopenia in HIV-Infected Patients. (23730018)
2012
14
Hemodialysis-associated acute systemic reactions and heparin-induced thrombocytopenia. (22127211)
2012
15
What are the options for anticoagulation needs in dialysis for patients with heparin-induced thrombocytopenia? (21851394)
2011
16
A clinical-laboratory algorithm incorporating optical density value to predict heparin-induced thrombocytopenia. (21264443)
2011
17
Exacerbation of thrombocytopenia in a pregnant woman with thrombocytopenia-absent radius syndrome. (21530967)
2011
18
Novel use of plasmapheresis in a patient with heparin-induced thrombocytopenia requiring urgent insertion of a left ventricular assist device under cardiopulmonary bypass. (20723718)
2010
19
False-positive tests for heparin-induced thrombocytopenia in patients with antiphospholipid syndrome and systemic lupus erythematosus: a rebuttal. (20345710)
2010
20
Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban]. (19795099)
2009
21
Clonal chromosome anomalies and propensity to myeloid malignancies in congenital amegakaryocytic thrombocytopenia (OMIM 604498). (18519517)
2008
22
Serologic results in >1000 patients with suspected heparin-induced thrombocytopenia. (17895512)
2008
23
Successful treatment of autoimmune pancreatitis complicated with autoimmune thrombocytopenia and interstitial pneumonia by prednisolone. (18520116)
2008
24
Spontaneous superior sagittal sinus thrombosis secondary to type II heparin-induced thrombocytopenia presenting as an acute subarachnoid hemorrhage. (17582771)
2007
25
Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit. (17464135)
2007
26
Review article: pharmacological approaches for the treatment of thrombocytopenia in patients with chronic liver disease and hepatitis C infection. (17958517)
2007
27
Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. (16466367)
2006
28
Successful renal transplantation in a patient with heterozygous prothrombin gene, factor V Leiden mutation and heparin-induced thrombocytopenia using r-hirudin as anticoagulant. (16499600)
2006
29
Use of ecarin clotting time in whole blood for monitoring recombinant hirudine treatment during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia]. (15771978)
2005
30
Patterns of thrombocytosis and thrombocytopenia in hospitalized neonates. (15578031)
2005
31
Mayer-Rokitansky-KA1ster-Hauser syndrome associated with thrombocytopenia-absent radius syndrome. (15705390)
2005
32
Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin-induced thrombocytopenia: an analysis of 3 prospective studies. (15280202)
2004
33
Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit. (12477267)
2002
34
Wilson disease manifested primarily as amenorrhea and accompanying thrombocytopenia. (12359384)
2002
35
Treatment of lupus-induced thrombocytopenia with recombinant human interleukin-11. (11212156)
2001
36
Mutations in the thrombopoietin receptor, Mpl, in children with congenital amegakaryocytic thrombocytopenia. (10971406)
2000
37
Sustained response to combination therapy in a patient with chronic hepatitis C and thrombocytopenia secondary to alpha-interferon. (10847447)
2000
38
Further examination of various administration protocols of pegylated recombinant human megakaryocyte growth and development factor on thrombocytopenia in myelosuppressed mice. (10227790)
1998
39
Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production. (8896400)
1996
40
Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia. (8826901)
1996
41
Osteopetrosis, anemia, thrombocytopenia, and marrow necrosis in beef calves naturally infected with bovine virus diarrhea virus. (8580185)
1995
42
Heparin-induced thrombocytopenia and thrombosis. (9372019)
1995
43
A case of common variable immunodeficiency associated with cyclic thrombocytopenia. (7871984)
1994
44
Dengue virus and endothelial cell: a related phenomenon to thrombocytopenia and granulocytopenia in dengue hemorrhagic fever. (7886587)
1993
45
The effect of a single course of alpha-2B-interferon in patients with HIV-related and chronic idiopathic immune thrombocytopenia. (8329555)
1993
46
Characterization of an antibody to the integrin beta 3 subunit (GP IIIa) from a patient with neonatal thrombocytopenia and an inherited deficiency of GP IIb-IIIa complexes in platelets (Glanzmann's thrombasthenia). (1633270)
1992
47
Plasma levels of endothelial-derived haemostatic factors in autoimmune thrombocytopenia and haemolytic anaemia. (2119418)
1990
48
Splenectomy for thrombocytopenia due to secondary hypersplenism. (3422554)
1988
49
Quinidine leukopenia and thrombocytopenia with a drug-dependent leukoagglutinin. (836544)
1977
50
Congenital lipomatosis of the pancreas. Malabsorption, dwarfism, leukopenia with relative granulocytopenia and thrombocytopenia. (5665293)
1968

Variations for Thrombocytopenia

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Expression for genes affiliated with Thrombocytopenia

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Search GEO for disease gene expression data for Thrombocytopenia.

Pathways for genes affiliated with Thrombocytopenia

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Pathways related to Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ITGA2, ITGA2B
29.7ITGA2, GP1BA
3
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.6MPL, THPO
49.4CYCS, ITGA2, ITGA2B
5
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility58
Cytoskeleton remodeling Integrin outside in signaling58
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases58
Cell adhesion Tight junctions58
Development MAG dependent inhibition of neurite outgrowth58
9.4ITGA2, ITGB3, WAS
69.3ITGB3, ITGA2B
79.3ITGB3, ITGA2B
89.3ITGA2B, ITGB3
99.0ITGA2, ITGB3, ITGA2B
109.0ITGA2, ITGA2B, ITGB3
11
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
9.0ITGB3, ITGA2B, ITGA2
129.0ITGA2B, ITGB3, ITGA2
139.0ITGB3, ITGA2B, ITGA2
14
Show member pathways
Development EDNRB signaling58
Development ACM2 and ACM4 activation of ERK58
Cell adhesion Integrin inside out signaling58
Development G Proteins mediated regulation MARK ERK signaling58
Signal transduction IP3 signaling58
Development Angiotensin signaling via PYK258
Development EPO induced MAPK pathway58
9.0ITGB3, ITGA2, ITGA2B
159.0ITGB3, ITGA2, ITGA2B
16
Show member pathways
8.8ITGA2B, ITGA2, ITGB3, WAS
17
Show member pathways
8.8ITGA2, ITGB3, WAS, ITGA2B
18
Show member pathways
8.8WAS, ITGA2, ITGA2B, ITGB3
19
Show member pathways
8.8ITGA2, ITGA2B, ITGB3, WAS
20
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
8.5ITGA2, ITGA2B, ITGB3, GP1BA
21
Show member pathways
8.5ITGA2B, GATA1, ITGA2, ITGB3, CYCS
228.2ITGA2, ITGA2B, ITGB3, IL3
23
Show member pathways
7.9GP1BA, THPO, ITGB3, ITGA2B, MPL
24
Show member pathways
7.8THPO, ITGA2B, IL3, ITGA2, ITGB3
25
Show member pathways
7.8ITGB3, ITGA2, ITGA2B, THPO, IL3
26
Show member pathways
7.6THPO, WAS, ITGB3, ITGA2B, ITGA2, IL3
27
Show member pathways
7.5CYCS, ITGA2B, ITGA2, IL3, THPO, ITGB3
28
Show member pathways
7.5ITGA2B, ITGA2, ITGB3, THPO, CYCS, IL3
29
Show member pathways
7.4GP1BA, MPL, ITGA2B, THPO, ITGA2, GATA1
30
Show member pathways
7.4ITGA2B, ITGB3, MPL, IL3, ITGA2, THPO
317.3ITGA2B, GP1BA, ITGB3, THPO, ITGA2, IL3

Compounds for genes affiliated with Thrombocytopenia

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Compounds related to Thrombocytopenia according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1megapoietin4310.0MPL, THPO
2anagrelide43 1211.0THPO, MPL
3aebsf439.9CFI, CYCS
4convulxin439.9ITGA2, GP1BA
5aclarubicin439.7GATA1, IL3
6bio 1211599.7ITGB3, ITGA2B
7leukadherin 1599.7ITGB3, ITGA2B
8obtustatin599.7ITGB3, ITGA2B
9a 286982599.7ITGB3, ITGA2B
10tc-i 15599.7ITGA2B, ITGB3
11homoharringtonine43 49 1211.7CYCS, IL3
12mafosfamide439.6THPO, IL3
13pixy321439.6THPO, IL3
14thromboxane43 2410.5GATA1, THPO, MPL, ITGA2
15amifostine43 1210.5IL3, THPO
16tirofiban43 1210.5ITGA2, ITGA2B, ITGB3
17latex439.5WAS, GP1BA, THPO, ITGA2
18filgrastim43 1210.4IL3, THPO
19hydroxyurea43 49 1211.4GATA1, THPO, IL3
20cytarabine43 49 1211.3THPO, IL3, GATA1
21abciximab43 1210.2GP1BA, ITGB3, ITGA2B
22ristocetin439.2ITGB3, GP1BA
23gp 130439.1MPL, IL3, THPO
24proline439.1ITGB3, ITGA2, GP1BA, WAS
25phosphatidylcholine439.1IL3, ITGA2, CYCS
26actinomycin d439.1THPO, CYCS, IL3, GATA1
27iron43 2410.0GATA1, ITGB3, MPL, THPO
2812-o-tetradecanoylphorbol 13-acetate439.0IL3, ITGA2B, ITGA2, GATA1
29butyrate438.9CYCS, IL3, ITGA2, THPO, GATA1
30vegf438.8ITGB3, MPL, THPO, ITGA2, GATA1
31cycloheximide438.8GATA1, IL3, ITGA2, CYCS
32prostacyclin438.8IL3, GP1BA, THPO
33phosphatidylserine43 28 1210.7ITGB3, GP1BA, CYCS
34atp43 289.7WAS, THPO, RBM8A, CYCS, ITGA2, ITGB3
35lactate438.6GP1BA, CYCS, THPO, IL3
36aspirin43 49 28 2411.6MPL, ITGA2, ITGB3, GP1BA, THPO
37lysine438.6ITGA2, THPO, MPL, ITGB3, ITGA2B
38heparin43 28 24 1211.5THPO, CFI, GP1BA, ITGA2, IL3
39retinoic acid43 249.5THPO, CYCS, CFI, ITGA2, GATA1, IL3
40glucose438.4THPO, CFI, GP1BA, ITGB3, ITGA2
41estrogen438.2THPO, IL3, ITGB3, GATA1, CFI
42fibrinogen438.2THPO, CFI, ITGA2, ITGA2B, GP1BA, ITGB3
43phosphatidylinositol438.2WAS, ITGA2, IL3, MPL, GP1BA, THPO
44threonine438.1ITGA2, IL3, ITGB3, MPL, GP1BA
45calcium43 49 24 1210.8WAS, ITGA2, ITGA2B, THPO, CFI, GP1BA
46alanine437.8THPO, GP1BA, MPL, IL3, HOXA11, ITGB3
47adp43 28 249.6MPL, MASTL, ITGA2, ITGA2B, ITGB3, WAS
48tyrosine437.5IL3, ITGA2, ITGB3, THPO, GP1BA, WAS
49cysteine437.5ITGB3, ITGA2B, MPL, CYCS, THPO, ITGA2
50serine436.8CYCS, CFI, GP1BA, MPL, WAS, ITGB3

GO Terms for genes affiliated with Thrombocytopenia

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Cellular components related to Thrombocytopenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1focal adhesionGO:00059259.0ITGA2, ITGA2B, ITGB3
2platelet alpha granule membraneGO:00310929.0ITGA2B, ITGB3
3integrin complexGO:00083059.0ITGA2, ITGA2B, ITGB3

Biological processes related to Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of leukocyte migrationGO:00026879.6ITGA2B, ITGA2
2embryonic hemopoiesisGO:00351629.4GATA1, IL3
3platelet aggregationGO:00705279.2GATA1, ITGA2B, ITGB3
4integrin-mediated signaling pathwayGO:00072299.1ITGB3, ITGA2B, ITGA2
5cell-matrix adhesionGO:00071609.1ITGA2, ITGA2B, ITGB3
6positive regulation of peptidyl-tyrosine phosphorylationGO:00507318.9ITGB3, IL3, GATA1
7cell adhesionGO:00071558.2ITGA2, ITGA2B, ITGB3, GP1BA
8platelet activationGO:00301688.1THPO, GP1BA, MPL, ITGB3, ITGA2B
9blood coagulationGO:00075967.4GATA1, THPO, GP1BA, MPL, WAS, ITGB3

Products for genes affiliated with Thrombocytopenia

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Sources for Thrombocytopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet