MCID: THR014
MIFTS: 65

Thrombocytopenia

Categories: Immune diseases, Rare diseases, Blood diseases, Genetic diseases

Aliases & Classifications for Thrombocytopenia

Summaries for Thrombocytopenia

PubMed Health : 59
About thrombocytopenia: Thrombocytopenia (THROM-bo-si-to-PE-ne-ah) is a condition in which your blood has a lower than normal number of blood cell fragments called platelets (PLATE-lets).Platelets are made in your bone marrow along with other kinds of blood cells. They travel through your blood vessels and stick together (clot) to stop any bleeding that may happen if a blood vessel is damaged. Platelets also are called thrombocytes (THROM-bo-sites) because a clot also is called a thrombus.

MalaCards based summary : Thrombocytopenia is related to thrombocytopenia 1 and thrombocytopenia-absent radius syndrome. An important gene associated with Thrombocytopenia is ETV6 (ETS Variant 6), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Actin Nucleation by ARP-WASP Complex. The drugs Carboplatin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and myeloid, and related phenotypes are cellular and hematopoietic system

Disease Ontology : 12 A blood platelet disease characterized by low a platelet count in the blood.

Wikipedia : 72 Thrombocytopenia is a condition characterized by abnormally low levels of thrombocytes, also known as... more...

Related Diseases for Thrombocytopenia

Diseases in the Thrombocytopenia family:

Thrombocytopenia 2 Thrombocytopenia 3
Thrombocytopenia 1 Thrombocytopenia 4
Thrombocytopenia 5 Thrombocytopenia 6
Acquired Thrombocytopenia Thrombocytopenia Due to Platelet Alloimmunization
Primary Thrombocytopenia

Diseases related to Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 680)
# Related Disease Score Top Affiliating Genes
1 thrombocytopenia 1 34.4 GATA1 HOXA11 WAS
2 thrombocytopenia-absent radius syndrome 34.1 ANKRD26 GATA1 GP1BA MPL
3 thrombocytopenia 2 34.0 ANKRD26 MASTL MECOM
4 thrombocytopenia due to platelet alloimmunization 33.8 ITGA2 ITGA2B MPL MYH9
5 autosomal thrombocytopenia with normal platelets 33.6 CYCS MASTL
6 radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome 33.3 HOXA11 MECOM
7 fetal and neonatal alloimmune thrombocytopenia 33.2 GP1BA GP1BB ITGA2 ITGA2B ITGB3
8 platelet disorder, familial, with associated myeloid malignancy 32.8 ANKRD26 ETV6
9 primary thrombocytopenia 32.5 ADAMTS13 GP1BA ITGA2 ITGA2B ITGB3 MPL
10 thrombocytopenic purpura, autoimmune 32.5 GP1BA IL11 ITGA2B ITGB3 MPL
11 myh-9 related disease 32.1 ANKRD26 GP1BA MYH9
12 gray platelet syndrome 31.9 GATA1 GP9 MASTL
13 aplastic anemia 31.6 GATA1 IL11 ITGA2B MPL
14 bernard-soulier syndrome 31.2 GP1BA GP1BB GP9 ITGA2 ITGA2B ITGB3
15 purpura 30.2 ADAMTS13 GP1BA ITGA2B ITGB3 MPL
16 velocardiofacial syndrome 30.2 GP1BA GP1BB GP9
17 bleeding disorder, platelet-type, 16 30.1 ITGA2B ITGB3
18 myelodysplastic syndrome 30.1 ETV6 GATA1 IL11 MECOM MPL
19 blood platelet disease 29.9 ADAMTS13 GP1BA GP1BB GP9 ITGA2B ITGB3
20 leukemia, acute myeloid 29.7 ETV6 GATA1 MECOM MPL SRC
21 leukemia, chronic myeloid 29.7 ETV6 MECOM MPL SRC
22 autosomal dominant macrothrombocytopenia 29.6 GP1BA GP1BB ITGA2B ITGB3 MYH9
23 essential thrombocythemia 29.5 GATA1 IL11 ITGA2B ITGB3 MPL
24 thrombasthenia 29.1 GP1BA GP9 ITGA2 ITGA2B ITGB3
25 myocardial infarction 29.1 ADAMTS13 GP1BA ITGA2 ITGA2B ITGB3
26 glanzmann thrombasthenia 28.8 GP1BA GP9 ITGA2 ITGA2B ITGB3
27 heparin-induced thrombocytopenia 12.4
28 amegakaryocytic thrombocytopenia, congenital 12.4
29 thrombocytopenia, paris-trousseau type 12.3
30 radioulnar synostosis with amegakaryocytic thrombocytopenia 1 12.3
31 thrombocytopenia with beta-thalassemia, x-linked 12.3
32 dyserythropoietic anemia and thrombocytopenia 12.2
33 hemangioma-thrombocytopenia syndrome 12.2
34 thrombocytopenia 4 12.2
35 thrombocytopenia, x-linked, with or without dyserythropoietic anemia 12.2
36 thrombocytopenia 5 12.2
37 acquired amegakaryocytic thrombocytopenia 12.2
38 acquired thrombocytopenia 12.1
39 thrombocytopenia 3 12.1
40 radioulnar synostosis with amegakaryocytic thrombocytopenia 2 12.1
41 thrombocytopenia 6 12.1
42 myh9 related thrombocytopenia 12.1
43 thrombocytopenia, anemia, and myelofibrosis 12.0
44 thrombocytopenia, cyclic 12.0
45 multifocal lymphangioendotheliomatosis with thrombocytopenia 12.0
46 thrombocytopenia robin sequence 12.0
47 transient neonatal thrombocytopenia 11.9
48 wiskott-aldrich syndrome 11.9
49 hereditary thrombocytopenia with normal platelets 11.9
50 thrombocytopenia with elevated serum iga and renal disease 11.8

Graphical network of the top 20 diseases related to Thrombocytopenia:



Diseases related to Thrombocytopenia

Symptoms & Phenotypes for Thrombocytopenia

MGI Mouse Phenotypes related to Thrombocytopenia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.17 CYCS ETV6 GATA1 GP1BA HOXA11 ITGA2
2 hematopoietic system MP:0005397 10.03 ITGA2B ITGB3 MECOM MPL MYH9 SRC
3 embryo MP:0005380 9.96 MPL MYH9 SRC CYCS ETV6 GATA1
4 homeostasis/metabolism MP:0005376 9.77 ADAMTS13 ANKRD26 ETV6 GATA1 GP1BA GP1BB
5 immune system MP:0005387 9.36 ITGA2B ITGB3 MECOM MPL MYH9 SRC

Drugs & Therapeutics for Thrombocytopenia

PubMedHealth treatment related to Thrombocytopenia: 59

Treatment for thrombocytopenia depends on its cause and severity. The main goal of treatment is to prevent death and disability caused by bleeding.If your condition is mild, you may not need treatment. A fully normal platelet count isn't necessary to prevent bleeding, even with severe cuts or accidents.Thrombocytopenia often improves when its underlying cause is treated. People who inherit the condition usually don't need treatment.If a reaction to a medicine is causing a low platelet count, your doctor may prescribe another medicine. Most people recover after the initial medicine has been stopped. For heparin-induced thrombocytopenia (HIT), stopping the heparin isn't enough. Often, you'll need another medicine to prevent blood clotting.If your immune system is causing a low platelet count, your doctor may prescribe medicines to suppress the immune system.

Drugs for Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 496)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
2
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
3
Gemcitabine Approved Phase 4,Phase 2,Phase 1 95058-81-4 60750
4
Oprelvekin Approved, Investigational Phase 4,Phase 2,Phase 3 145941-26-0
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
6 Certoparin Approved, Investigational Phase 4,Phase 3
7
Dalteparin Approved Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6
8
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 46507594 772
9
Bivalirudin Approved, Investigational Phase 4,Phase 3 128270-60-0 16129704
10
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
11
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
12
Oxaliplatin Approved, Investigational Phase 4,Phase 2 61825-94-3 43805 6857599 5310940 9887054
13
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
14
Idarubicin Approved Phase 4,Phase 3,Phase 2 58957-92-9 42890
15
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
16
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
17
Ribavirin Approved Phase 4,Phase 2,Phase 3 36791-04-5 37542
18
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
19
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
20
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
21
Dexlansoprazole Approved, Investigational Phase 4,Phase 2 138530-94-6, 103577-45-3 9578005
22
Lansoprazole Approved, Investigational Phase 4,Phase 2 103577-45-3 3883
23
alemtuzumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 216503-57-0
24 Fondaparinux Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104993-28-4
25
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666
26
Fludarabine Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 21679-14-1, 75607-67-9 30751
27
Vidarabine Approved, Investigational Phase 4,Phase 3,Phase 2 24356-66-9 21704 32326
28
Argatroban Approved, Investigational Phase 4,Phase 3,Phase 2 74863-84-6 152951
29
Abciximab Approved Phase 4,Phase 3 143653-53-6
30 Nadroparin Approved, Investigational Phase 4 9041-08-1
31
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
32
Fluorouracil Approved Phase 4,Phase 3,Phase 2 51-21-8 3385
33
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
34
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
35
Ticlopidine Approved Phase 4 55142-85-3 5472
36
Desirudin Approved Phase 4,Phase 2,Phase 3 120993-53-5
37
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2
38
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2 198153-51-4 5360545
39
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
40
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 46835353 6436030 5284616
41
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 104987-11-3 445643 439492
42
Azathioprine Approved Phase 4,Phase 3,Phase 1 446-86-6 2265
43
Hydroxychloroquine Approved Phase 4,Phase 3 118-42-3 3652
44
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
45
Dimethyl sulfoxide Approved, Vet_approved Phase 4,Phase 1 67-68-5 679
46
Lepirudin Approved Phase 4 138068-37-8, 120993-53-5 16132441
47
Warfarin Approved Phase 4,Phase 3,Phase 2 81-81-2 54678486 6691
48
Abatacept Approved Phase 4 332348-12-6 10237
49
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2 58-05-9 143 6006
50
Caffeic acid Experimental, Investigational Phase 4,Phase 3 331-39-5 1549111

Interventional clinical trials:

(show top 50) (show all 822)

# Name Status NCT ID Phase Drugs
1 The Study of rHuTPO/rHuIL-11 in the Treatment for Chemotherapy-induced Thrombocytopenia in Patients With NSCLC Unknown status NCT02344979 Phase 4
2 Caffeic Acid Combining High-dose Dexamethasone in Management of ITP Unknown status NCT02556814 Phase 4 Caffeic acid tablets;Dexamethasone;placebo
3 The HIT-TRAP Trial Unknown status NCT00196417 Phase 4 Standard heparin (UFH) versus certoparin (LMWH)
4 Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients Unknown status NCT02355873 Phase 4
5 Efficacy and Safety of rHuTPO on Platelet Engraftment After Allo-HSCT Unknown status NCT01379391 Phase 4 Recombinant Human Thrombopoietin (rHTPO)
6 Comparing Bivalirudin Versus Heparin/ GP IIB/IIA in Patients Undergoing PCI Unknown status NCT00476944 Phase 4
7 Impact of Heparin on the Need for Mechanical Ventilation in Neonates Unknown status NCT00196469 Phase 4 heparin
8 The Study of Different Dose Rituximab in the Treatment of ITP Completed NCT03258866 Phase 4 Rituximab;Rituximab
9 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
10 Bivalirudin PCI Registry in Heparin Induced Thrombocytopenia/Heparin Induced Thrombocytopenia and Thrombosis Syndrome (HIT/HITTS) Patients Completed NCT00759083 Phase 4 bivalirudin
11 A Study to Confirm the Efficacy and Safety of Fludarabine Phosphate Administered in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia Completed NCT00220311 Phase 4 Fludarabine Phosphate (Fludara)
12 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
13 Evaluation of Argatroban Injection in Pediatric Patients Requiring Anticoagulant Alternatives to Heparin Completed NCT00039858 Phase 4 Argatroban
14 High-dose Dexamethasone Versus Conventional Dose Prednisone for Initial Treatment of Primary Immune Thrombocytopenia (ITP) Completed NCT01356511 Phase 4 Prednisone;Dexamethasone
15 Study to Reveal if Fibrinogen Treatment Effects Blood Clotting Better Than a Platelet Transfusion Completed NCT01955811 Phase 4 Administration of platelet concentrate and taking blood samples
16 Evaluation of the Efficacy of Platelets Treated With Pathogen Reduction Process Completed NCT01789762 Phase 4
17 EArly Discharge After Transradial Stenting of CoronarY Arteries: The EASY Study Completed NCT00169819 Phase 4 Abciximab
18 Enoxaparin Versus Unfractionated Heparin in PCI Completed NCT00439855 Phase 4 Enoxaparin i.v.;unfractionated heparin
19 Nadroparin for the Initial Treatment of Pulmonary Thromboembolism Completed NCT00796692 Phase 4 Nadroparin;Unfractionated heparin(UFH)
20 Value of Abciximab in Patients With AMI Undergoing Primary PCI After Clopidogrel Pretreatment (BRAVE 3) Completed NCT00133250 Phase 4 Abciximab
21 Venous Thromboembolic Prophylaxis After Trauma: Three Times a Day Unfractionated Heparin Versus Twice a Day Enoxaparin Completed NCT01729559 Phase 4 5000 Units unfractionated Heparin Q 8 hr;30mg enoxaparin Q12 hr
22 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
23 Study to Evaluate the Mortality Reduction of Enoxaparin in Hospitalized Acutely Ill Medical Receiving Enoxaparin Completed NCT00622648 Phase 4 Enoxaparin;Placebo
24 EXCLAIM:Extended Prophylaxis for Venous ThromboEmbolism (VTE) in Acutely Ill Medical Patients With Prolonged Immobilization Completed NCT00077753 Phase 4 enoxaparin sodium
25 Intensified Dosing of Cellcept (Mycophenolate Mofetil) in Kidney Transplantation Completed NCT00943228 Phase 4 mycophenolate mofetil
26 SMD_FLAG-IDA_98: FLAG-IDA in Induction Treatment of High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia Completed NCT00487448 Phase 4 Fludarabine;Cytarabine;G-CSF;Idarubicin
27 Platelet Function in Idiopathic Thrombocytopenic Purpura (ITP) Patients With Eltrombopag Completed NCT00888901 Phase 4 eltrombopag;corticosteroids (Aprednislon)
28 Efficacy of Abciximab Bolus Only Regimen in Providing Inhibition of Platelet Action Over Time Completed NCT00929279 Phase 4 bolus+infusion;abciximab bolus only regimen
29 Safety Study of Stopping Thromboprophylaxis Based on Ultrasound Results After Total Knee Replacement Completed NCT00362492 Phase 4
30 Safety Study of Desirudin, an Anticoagulant for the Prophylaxis of Thrombosis Completed NCT00913133 Phase 4 Desirudin
31 A Study of The Relationship Between Drop in Hemoglobin and Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Copegus (Ribavirin) and Pegasys (Peginterferon Alfa-2a) Completed NCT01585324 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin [Copegus]
32 How Effective Are Antithrombotic Therapies in Primary Percutaneous Coronary Intervention Completed NCT01519518 Phase 4 unfractionated heparin;Bivalirudin
33 Study Evaluating A Planned Transition From Tacrolimus To Sirolimus In Kidney Transplant Recipients Completed NCT00895583 Phase 4 Tacrolimus;Sirolimus;Tacrolimus
34 A Safety Study of Intravenous Immunoglobulin in Patients With Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT01390649 Phase 4
35 A Longitudinal 2-year Bone Marrow Study of Eltrombopag in Previously Treated Adults, With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT01098487 Phase 4 Eltrombopag olamine
36 Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura Completed NCT00467571 Phase 4 lansoprazole, clarithromycin, amoxycillin
37 The Efficacy and Safety of Huaiqihuang Granule in Children With Chronic Primary Immune Thrombocytopenia Recruiting NCT03201848 Phase 4 Placebo;Huaiqihuang Granule
38 Efficacy and Safety of rhTPO for the Treatment of Thrombocytopenia After Chemotherapy in AML Patients Recruiting NCT02267993 Phase 4 recombinant human thrombopoietin
39 Immunomodulation With Romiplostim in Young Adults With ITP Recruiting NCT02760251 Phase 4 romiplostim
40 Rate of Prolonged Response After Stopping Thrombopoietin-receptor Agonists Treatment in ITP Recruiting NCT03119974 Phase 4 Tpo-RA discontinuation
41 A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab) Recruiting NCT01734382 Phase 4 Tocilizumab
42 Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction Recruiting NCT01935128 Phase 4 Arm 1 Everolimus/Reduced dose tacrolimus
43 Thromboprophylaxis of Venous Thromboembolism in Acutely-ill Medical Inpatients With Thrombocytopenia Active, not recruiting NCT01727401 Phase 4 Fondaparinux
44 A Rollover Study to Provide Continued Treatment With Eltrombopag Active, not recruiting NCT01957176 Phase 4 ELT
45 Eval. of Potential Predictors of Disease Progression in Patients With aHUS Including Genetics, Biomarkers and Treatment Active, not recruiting NCT02614898 Phase 4
46 Study Assessing an Algorithm-based Strategy of Eculizumab Discontinuation in Children and Adults With aHUS Active, not recruiting NCT02574403 Phase 4 eculizumab
47 Reposition of Second Line Treatment in Chronic Immune Thrombocytopenia Not yet recruiting NCT03229746 Phase 4 Hydroxychloroquine;vincristine;azathioprine
48 Effects of Helicobacter Pylori Eradication in Children With Chronic Immune Thrombocytopenic Purpura Not yet recruiting NCT03172676 Phase 4 Amoxicillin 50 mg/kg/day in 2 divided doses for 14 days.;Clarithromycin 15 mg/kg/day in 2 divided doses for 14 days.;Proton pump inhibitor 1 mg/kg/day in 2 divided doses 1 month
49 Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders Not yet recruiting NCT03227419 Phase 4 Tocilizumab Prefilled Syringe;Abatacept Prefilled Syringe
50 Normal Saline Versus Heparinized Solution Flush for Maintaining Patency of Peripheral Venous Catheters in Children Suspended NCT01794767 Phase 4 0,9% NaCl flush;Heparin 50U/ml

Search NIH Clinical Center for Thrombocytopenia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Thrombocytopenia cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: thrombocytopenia

Genetic Tests for Thrombocytopenia

Genetic tests related to Thrombocytopenia:

# Genetic test Affiliating Genes
1 Thrombocytopenia 28

Anatomical Context for Thrombocytopenia

MalaCards organs/tissues related to Thrombocytopenia:

38
Liver, Bone, Myeloid, Bone Marrow, Testes, Kidney, Lung

Publications for Thrombocytopenia

Articles related to Thrombocytopenia:

(show top 50) (show all 2774)
# Title Authors Year
1
Case 4-2018: A Newborn with Thrombocytopenia, Cataracts, and Hepatosplenomegaly. ( 29414276 )
2018
2
Abciximab/Heparin During Acute Heparin-Induced Thrombocytopenia: A Word of Caution. ( 29305853 )
2018
3
Steroid pulse therapy in patients with encephalopathy associated with severe fever with thrombocytopenia syndrome. ( 29428565 )
2018
4
Recurrent Viral Infections Complicated with Cold Agglutinin Disease after Splenectomy for Thrombocytopenia. ( 29336379 )
2018
5
Kinetics of viral load and cytokines in severe fever with thrombocytopenia syndrome. ( 29427908 )
2018
6
Successful Use of Intravenous Immunoglobulin G to Treat Refractory Heparin-Induced Thrombocytopenia With Thrombosis Complicating Peripheral Blood Stem Cell Harvest. ( 29404376 )
2018
7
Heparin-induced thrombocytopenia complicating children after the Fontan procedure: Single-center experience and review of the literature. ( 29181882 )
2018
8
Dynamic dosing of romiplostim in patients with immune thrombocytopenia purpura: Two case reports. ( 29357781 )
2018
9
Evaluating Thrombocytopenia During Heparin Therapy. ( 29411014 )
2018
10
Platelet-Activating Antibodies Are Detectable at the Earliest Onset of Heparin-Induced Thrombocytopenia, With Implications for the Operating Characteristics of the Serotonin-Release Assay. ( 29325985 )
2018
11
Abciximab/Heparin During Acute Heparin-induced Thrombocytopenia: A Word of Caution (Reply). ( 29371038 )
2018
12
Recent advances in understanding and management of acquired thrombocytopenia. ( 29399327 )
2018
13
Phlegmasia Cerulea Dolens Following Heparin-Induced Thrombocytopenia. ( 29422736 )
2018
14
Thrombocytopenia in high-risk patients with antiphospholipid syndrome. ( 29316193 )
2018
15
Heparin-Induced Thrombocytopenia during Obstetric Hospital Admissions. ( 29421832 )
2018
16
Laboratory tests for identification or exclusion of heparin induced thrombocytopenia: HIT or miss? ( 29164662 )
2018
17
Initial and long term impact of a multi-disciplinary task force in the diagnosis and management of heparin-induced thrombocytopenia. ( 29185142 )
2018
18
A MECOM variant in an African American child with radioulnar synostosis and thrombocytopenia. ( 29200407 )
2018
19
Outcomes of Endoscopic Intervention for Overt Gastrointestinal Bleeding in Severe Thrombocytopenia. ( 29408558 )
2018
20
Immune dysregulation in primary immune thrombocytopenia patients. ( 29409398 )
2018
21
Integrated mRNA and miRNA profiling revealed deregulation of cellular stress response in bone marrow mesenchymal stem cells derived from patients with immune thrombocytopenia. ( 29442265 )
2018
22
Subacute sclerosing panencephalitis and immune thrombocytopenia: More than a coincidence? ( 29407001 )
2018
23
Intracranial hemorrhages in neonates born from 32 weeks of gestation-low frequency of associated fetal and neonatal alloimmune thrombocytopenia: a register-based study. ( 29119564 )
2018
24
Delayed-onset heparin-induced thrombocytopenia complicated by arterial and venous thromboses. ( 29314517 )
2018
25
Acquired amegakaryocytic thrombocytopenia and red cell aplasia in a patient with thymoma progressing to aplastic anemia successfully treated with allogenic stem cell transplantation. ( 29409729 )
2018
26
Patients treated with oxaliplatin are at risk for thrombocytopenia caused by multiple drug-dependent antibodies. ( 29439950 )
2018
27
Screening for fetal and neonatal alloimmune thrombocytopenia - lessons learned from a Norwegian screening program. ( 29412452 )
2018
28
Evaluation of the Incidence of Ibuprofen Administration in Alcohol and Opioid Detoxification Patients With Concomitant Thrombocytopenia. ( 29434386 )
2018
29
Thrombopoietin levels in Quebec platelet disorder-Implications for the mechanism of thrombocytopenia. ( 29388746 )
2018
30
Adding to the complexity of fetal and neonatal alloimmune thrombocytopenia: Reduced fibrinogen binding in the presence of anti-HPA-1a antibody and hypo-responsive neonatal platelets. ( 29306729 )
2018
31
Significance of thrombocytopenia in patients with primary and postessential thrombocythemia/polycythemia vera myelofibrosis. ( 29226426 )
2018
32
Drug-induced thrombocytopenia: Focus on platelet apoptosis. ( 29410286 )
2018
33
Incidence of leukopenia and thrombocytopenia with cisplatin plus mitomycin-c versus melphalan in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). ( 29429054 )
2018
34
The impact of acquired thrombocytopenia on long-term outcomes of patients undergoing elective percutaneous coronary intervention: An analysis of 8,271 consecutive patients. ( 29368387 )
2018
35
Differential Expression of MiR-106b-5p and MiR-200c-3p in Newly Diagnosed Versus Chronic Primary Immune Thrombocytopenia Patients Based on Systematic Analysis. ( 29402802 )
2018
36
Clinical features of fatal severe fever with thrombocytopenia syndrome that is complicated by invasive pulmonary aspergillosis. ( 29428567 )
2018
37
Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency. ( 29350338 )
2018
38
FcI^ receptor expression on splenic macrophages in adult immune thrombocytopenia. ( 28142207 )
2017
39
Use of systemic bivalirudin with catheter-directed thrombolysis in a patient with heparin-induced thrombocytopenia: A case report. ( 29068112 )
2017
40
Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia. ( 28054583 )
2017
41
MYH9-Related Thrombocytopenia. ( 28688473 )
2017
42
Immune Thrombocytopenia as a Consequence of Rocky Mountain Spotted Fever. ( 29279696 )
2017
43
Evaluation of 4T's scoring system in the identification of heparin-induced thrombocytopenia in patients with mechanical circulatory support. ( 29112890 )
2017
44
Effectiveness of a Laboratory Gate-Keeping Strategy to Overcome Inappropriate Test Utilization for the Diagnosis of Heparin-Induced Thrombocytopenia. ( 28750423 )
2017
45
Etiology and complications of thrombocytopenia in hospitalized medical patients. ( 28054307 )
2017
46
Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome. ( 28086978 )
2017
47
Paroxysmal Nocturnal Hemoglobinuria in the Differential Diagnosis of Thrombocytopenia. ( 28435653 )
2017
48
Diffuse Chorangiomatosis as a Cause of Cardiomegaly, Microangiopathic Hemolytic Anemia and Thrombocytopenia in a Newborn. ( 29227711 )
2017
49
Is low serum albumin level a significant predictor for the development of heparin-induced thrombocytopenia-thrombosis? ( 28289828 )
2017
50
Factor XIII Deficiency and Thrombocytopenia Are Frequent Modulators of Postoperative Clot Firmness in a Surgical Intensive Care Unit. ( 28503124 )
2017

Variations for Thrombocytopenia

ClinVar genetic disease variations for Thrombocytopenia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ETV6 NM_001987.4(ETV6): c.641C> T (p.Pro214Leu) single nucleotide variant Pathogenic/Likely pathogenic rs724159947 GRCh38 Chromosome 12, 11869601: 11869601
2 ETV6 NM_001987.4(ETV6): c.1106G> A (p.Arg369Gln) single nucleotide variant Pathogenic rs724159946 GRCh38 Chromosome 12, 11884541: 11884541
3 ETV6 NM_001987.4(ETV6): c.1195C> T (p.Arg399Cys) single nucleotide variant Pathogenic rs724159945 GRCh37 Chromosome 12, 12038902: 12038902
4 ETV6 NM_001987.4(ETV6): c.1153-5_1153-1delAACAG deletion Pathogenic rs786205154 GRCh37 Chromosome 12, 12038855: 12038859
5 ETV6 NM_001987.4(ETV6): c.1046T> C (p.Leu349Pro) single nucleotide variant Pathogenic rs786205155 GRCh37 Chromosome 12, 12037415: 12037415

Expression for Thrombocytopenia

Search GEO for disease gene expression data for Thrombocytopenia.

Pathways for Thrombocytopenia

Pathways related to Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 GATA1 GP1BA GP1BB GP9 ITGA2 ITGA2B
2
Show member pathways
12.91 ITGA2 ITGA2B ITGB3 MYH9 SRC WAS
3
Show member pathways
12.84 ITGA2 ITGA2B ITGB3 MYH9 SRC WAS
4
Show member pathways
12.77 CYCS ITGA2 ITGA2B ITGB3 SRC
5
Show member pathways
12.55 ITGA2 ITGB3 MYH9 SRC WAS
6 12.53 ITGA2 ITGA2B ITGB3 MYH9 SRC WAS
7
Show member pathways
12.33 ITGA2 ITGA2B ITGB3 SRC
8
Show member pathways
12.12 ITGA2 ITGA2B ITGB3 SRC
9
Show member pathways
12.1 ITGA2 ITGA2B ITGB3 MYH9 SRC WAS
10
Show member pathways
12.09 GP1BA GP1BB GP9 ITGA2 ITGA2B ITGB3
11
Show member pathways
11.95 ITGA2 ITGA2B ITGB3 SRC
12 11.91 GP1BA IL11 ITGA2 ITGA2B ITGB3 MPL
13 11.86 ITGA2 ITGA2B ITGB3 SRC
14 11.79 GP1BA GP1BB GP9 ITGA2 ITGA2B ITGB3
15 11.77 CYCS ITGA2 ITGA2B
16 11.72 ITGA2 ITGA2B ITGB3
17 11.52 ITGA2 ITGA2B ITGB3
18 11.51 GP1BB GP9 ITGA2 ITGA2B ITGB3
19
Show member pathways
11.49 GP1BA GP1BB GP9 ITGA2B ITGB3 MPL
20 11.46 ITGA2B ITGB3 SRC
21 11.44 GATA1 GP9 ITGA2B ITGB3
22 11.39 IL11 ITGA2 SRC
23 11.31 IL11 ITGA2 ITGA2B ITGB3
24 11.24 ITGA2B ITGB3 SRC
25 11.15 GP1BA GP1BB GP9 IL11 ITGA2 ITGA2B
26 11.12 ITGA2B ITGB3 SRC
27 10.74 GP1BA GP1BB GP9 ITGA2
28 10.56 GP1BA GP1BB GP9 SRC

GO Terms for Thrombocytopenia

Cellular components related to Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.43 ADAMTS13 GP1BA ITGA2 ITGA2B ITGB3 MPL
2 platelet alpha granule membrane GO:0031092 9.16 ITGA2B ITGB3
3 integrin complex GO:0008305 8.92 ITGA2 ITGA2B ITGB3 MYH9

Biological processes related to Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.86 GP1BA GP1BB GP9 ITGA2 ITGA2B ITGB3
2 cell-matrix adhesion GO:0007160 9.76 ADAMTS13 ITGA2 ITGA2B ITGB3
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.73 GATA1 IL11 ITGB3 SRC
4 regulation of megakaryocyte differentiation GO:0045652 9.67 GATA1 GP1BA ITGA2B
5 hemostasis GO:0007599 9.67 ADAMTS13 GP1BA GP1BB GP9
6 platelet activation GO:0030168 9.63 ADAMTS13 GP1BA GP1BB GP9 ITGB3 SRC
7 platelet aggregation GO:0070527 9.62 GATA1 ITGA2B ITGB3 MYH9
8 platelet formation GO:0030220 9.6 GATA1 MYH9
9 cell-substrate adhesion GO:0031589 9.59 ITGA2 ITGB3
10 cell adhesion mediated by integrin GO:0033627 9.58 ITGA2 ITGB3
11 uterus development GO:0060065 9.58 HOXA11 SRC
12 blood coagulation, intrinsic pathway GO:0007597 9.58 GP1BA GP1BB GP9
13 actin filament-based movement GO:0030048 9.57 MYH9 WAS
14 positive regulation of leukocyte migration GO:0002687 9.56 ITGA2 ITGA2B
15 hematopoietic stem cell proliferation GO:0071425 9.55 ETV6 MECOM
16 mesodermal cell differentiation GO:0048333 9.54 ITGA2 ITGB3
17 response to amine GO:0014075 9.52 ADAMTS13 ITGA2
18 regulation of bone resorption GO:0045124 9.51 ITGB3 SRC
19 megakaryocyte differentiation GO:0030219 9.48 GATA1 IL11
20 integrin-mediated signaling pathway GO:0007229 9.43 ADAMTS13 ITGA2 ITGA2B ITGB3 MYH9 SRC
21 blood coagulation GO:0007596 9.23 ADAMTS13 GATA1 GP1BA GP1BB GP9 ITGA2

Molecular functions related to Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 ADAMTS13 ANKRD26 CYCS ETV6 GATA1 GP1BA
2 integrin binding GO:0005178 8.92 ADAMTS13 ITGA2 ITGB3 SRC

Sources for Thrombocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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