Thrombocytopenia malady

Wikipedia: Thrombocytopenia (or thrombopenia) is a relative decrease of platelets in blood.⁴⁴ more...

MalaCards: Thrombocytopenia, also known as platelet count below reference range, is related to heparin-induced thrombocytopenia and thrombocytopenia-absent radius syndrome. An important gene associated with Thrombocytopenia is GATA1 (GATA binding protein 1 (globin transcription factor 1)), and among its related pathways are Staphylococcus aureus infection and Blood Coagulation Signaling Pathways. The drugs interferon gamma-1b and danaparoid sodium and the compounds mannose and folate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen, and related mouse phenotypes are digestive/alimentary and mortality/aging.

Aliases & Descriptions:

thrombocytopenia 6 7 8 32 43 platelet count below reference range 6

Disease types for thrombocytopenia family:

thrombocytopenia 2	thrombocytopenia 4

Diseases related to thrombocytopenia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1012)

id	Related Disease	Score	Top Affiliating Genes
1	heparin-induced thrombocytopenia	39.7	SELE, SELP, SERPINC1, SERPINE1, MTHFR, AZU1
2	thrombocytopenia-absent radius syndrome	35.1	MPL, MKKS, HRAS, HOXA10, HOXA11, THPO
3	congenital amegakaryocytic thrombocytopenia	34.8	MPL, IL18R1, IL3, THPO
4	neonatal alloimmune thrombocytopenia	33.8	ITGA2, ITGA2B, ITGB2, ITGB3, MMRN1, HLA-DRB3
5	dyserythropoietic anemia with thrombocytopenia	33.4	KITLG, MPL, IL11, IL3, FAS, IFNA1
6	hepatitis	33.1	SELP, FASLG, FAS, GPT, IFNA1, IFNA2
7	wiskott-aldrich syndrome	32.9	RECK, WAS, WASL, CD40LG, CD44, ITGA2
8	thrombocytopenia due to platelet alloimmunization	32.9	SELP, MPL, ITGA2B, GP5, THPO
9	evans' syndrome	32.9	IL6, APOH, F2, HP, ADAMTS13
10	von willebrand's disease	32.9	VWF, SELP, ITGA2B, IL11, GP1BA, F9
11	thrombocytopenia, x-linked	31.6	WAS, ZFPM1, THPO, GATA1
12	systemic lupus erythematosus	31.3	FCGR2B, FASLG, MBL2, TREX1, PTPN22, TLR5
13	thromboembolism	31.2	VWF, SELP, SERPINC1, SERPINE1, MTHFR, ITGA2
14	autoimmune thrombocytopenic purpura	30.5	SELP, MPL, ITGB3, IL11, IL18, GP1BA
15	gray platelet syndrome	30.4	NBEAL2, SELP, CD36, CD40LG, MASTL, GP5
16	hemolytic anemia	30.3	VWF, CFH, CD47, APOH, IFNA2, F3
17	hepatitis c	30.2	CD40LG, IL10, IL18, IL2, FAS, GPT
18	thrombotic thrombocytopenic purpura, acquired	29.7	VWF, SELE, SELP, SERPINE1, CFH, CD46
19	thrombocytosis	29.7	KITLG, VWF, SELP, SERPINC1, MTHFR, MPL
20	hypersplenism	29.6	IL11, F2, ALB, TLR4, THPO, CSF2
21	myelodysplastic syndrome	29.5	KITLG, SELL, MPL, CDKN2B, IL11, IL1A
22	atypical hemolytic-uremic syndrome	29.1	CFB, CFH, CFI, CD46, THBD, C3
23	antiphospholipid syndrome	29.1	VWF, SELE, SELP, SERPINC1, SERPINE1, MTHFR
24	aplastic anemia	29.1	KITLG, MPL, IL11, IL3, FASLG, FAS
25	portal hypertension	29.0	GPT, F2, ALB, EDN1, THPO, SLC17A5
26	thrombasthenia	28.8	RECK, VWF, MTHFR, CD47, CD9, ITGA2
27	bernard-soulier syndrome	28.7	RECK, VWF, ITGA2, ITGA2B, ITGB3, GP5
28	polycythemia vera	28.6	KITLG, VWF, SELP, SERPINC1, SERPINE1, MPL
29	glanzmann's thrombasthenia	28.6	RECK, VWF, CD47, CD9, ITGA2, ITGA2B
30	chronic myeloid leukemia	28.5	KITLG, SELP, MYB, RAF1, MPL, CDKN1A
31	liver cirrhosis	28.5	SERPINC1, RAF1, IL11, ANGPT1, GPT, GP1BA
32	venous thrombosis	28.3	VWF, SELP, SERPINC1, SERPINE1, MTHFR, ITGAM
33	splenomegaly	28.3	MPL, ITGB2, ITK, IL10, APOE, FASLG
34	malaria	28.2	CD36, CD40LG, FCGR2B, IL10, IL1A, IFNG
35	hellp syndrome	28.0	VWF, SERPINC1, SERPINE1, BCHE, MTHFR, CD46
36	acute fatty liver of pregnancy	27.8	SERPINC1, F3, F2, ALB
37	pancytopenia	27.8	MPL, ITK, ITPA, MGMT, IL3, IFNG
38	dengue disease	27.7	PIK3C2A, CD40LG, IVNS1ABP, FCGR1A, SLC17A5, NEU1
39	myelofibrosis	27.6	MPL, HRAS, THPO, EPO
40	polycythemia	27.6	KITLG, VWF, SELP, SERPINC1, SERPINE1, MPL
41	congenital disorder of glycosylation	27.5	VWF, SERPINC1, ALB, HP, PMM2, NEU1
42	thalassemia	27.5	PIK3C2A, KLF1, VWF, SELE, SERPINC1, MYB
43	adult-onset still's disease	27.3	IL18, IL1R1, IL6, CRP, CSF1
44	thrombosis	27.2	PIK3C2A, RECK, VWF, SELE, SELL, SELP
45	angiosarcoma	27.2	KITLG, VWF, FLI1, IL2, ANGPT1, IFNA1
46	pulmonary embolism	26.9	PIK3C2A, SERPINC1, SERPINE1, MTHFR, INS, APOH
47	gaucher's disease	26.9	MTHFR, CD36, IL18, IL1R1, IL6, MBL2
48	dengue hemorrhagic fever	26.7	SERPINC1, CFH, CD40LG, IVNS1ABP, ITGB3, FCGR2A
49	chronic lymphocytic leukemia	26.6	SELL, MYB, MS4A1, CD70, CDKN2B, CD40LG
50	cold agglutinin disease	26.6	MS4A1, IL6, HP, TNF, CRP

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 anagrelide, anagrelide hydrochloride, argatroban, danaparoid, danaparoid sodium, desmopressin, desmopressin acetate, interferon, interferon alfa 2-b, interferon alfa-2a, interferon alfa-2a,recombinant, interferon alfa-2b,recombinant, interferon alfa-3n,human leukocyte derived, interferon alfacon-1, interferon beta-1a,recombinant, interferon beta-1b,recombinant, interferon gamma-1b, lepirudin, peginterferon alfa-2a, peginterferon alfa-2b

MalaCards organs/tissues related to thrombocytopenia:

²²

MGI Mouse Phenotypes related to thrombocytopenia:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary phenotype	MP:0005381	INF	WAS, WASL, KITLG, VWF, , CDKN1A
2	mortality/aging	MP:0010768	INF	PIK3C2A, KLF1, RECK, WASL, KITLG, VWF
3	cardiovascular system phenotype	MP:0005385	INF	RECK, WASL, KITLG, VWF, SELE, SELL
4	hematopoietic system phenotype	MP:0005397	INF	KLF1, WAS, RASGRP2, ZFPM1, MPL, CDKN1A
5	cellular phenotype	MP:0005384	INF	WAS, WASL, KITLG, VWF, SELE, SELL
6	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, KLF1, WAS, KITLG, VWF,
7	embryogenesis phenotype	MP:0005380	INF	KLF1, RECK, WASL, SERPINC1, MYB, RAF1
8	nervous system phenotype	MP:0003631	INF	RECK, WASL, KITLG, VWF, SELP, SERPINC1
9	renal/urinary system phenotype	MP:0005367	INF	KLF1, WAS, , SELP, ,
10	limbs/digits/tail phenotype	MP:0005371	INF	RECK, KITLG, MTHFR, , CD44, CD47
11	endocrine/exocrine gland phenotype	MP:0005379	INF	WAS, WASL, SELL, CDKN2B, CDKN1B, CD40LG
12	normal phenotype	MP:0002873	INF	WASL, SELE, MYB, RAF1, ZFPM1,
13	behavior/neurological phenotype	MP:0005386	INF	, SELE, SELP, CDKN1A, CDKN1B, CD44
14	muscle phenotype	MP:0005369	INF	RAF1, CDKN1A, CD36, CDKN1B, CD44, CD47
15	respiratory system phenotype	MP:0005388	INF	SELL, SELP, IVNS1ABP, ITGB3, ITPA, MKKS
16	tumorigenesis	MP:0002006	6.2	WAS, KITLG, SELL, SERPINE1, CDKN1A, CDKN2B
17	no phenotypic analysis	MP:0003012	INF	MTHFR, CD79A, CDKN1B, CD44, INS, MGMT
18	vision/eye phenotype	MP:0005391	INF	KITLG, SELE, SELP, SERPINC1, RAF1, MTHFR
19	growth/size phenotype	MP:0005378	INF	PIK3C2A, RECK, WASL, KITLG, SELE, SELP
20	immune system phenotype	MP:0005387	INF	KLF1, WAS, WASL, VWF, SELL, SELP
21	adipose tissue phenotype	MP:0005375	INF	PIK3C2A, SERPINE1, CDKN1A, CD36, CDKN1B,
22	reproductive system phenotype	MP:0005389	INF	BCHE, , CDKN2B, CDKN1B, CD44,
23	craniofacial phenotype	MP:0005382	INF	KITLG, , MKKS, FLNA, , IL17A
24	liver/biliary system phenotype	MP:0005370	INF	KLF1, RECK, , SERPINC1, MYB, ZFPM1
25	other phenotype	MP:0005395	INF	RECK, CD40LG, ITGB3, IL11RA, IL2,
26	integument phenotype	MP:0010771	INF	KLF1, RECK, KITLG, , SELP, MYB
27	skeleton phenotype	MP:0005390	INF	RECK, WAS, KITLG, BMP6, RAF1, MTHFR

Articles related to thrombocytopenia:

(show top 50)    (show all 622)

id	Title	Authors	Year	Affiliating Genes
1	Congenital amegakaryocytic thrombocytopenia: clinical presentation, diagnosis, and treatment. (22102270)	Ballmaier M.... Germeshausen M.	2011	MPL
2	Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients. (18805962)	Federici A.B.... de Groot P.G.	2009	VWF, GP1BA
3	Heparin induced thrombocytopenia in a patient with fa ctor V Leiden following cardiac surgery. (19783545)	Chaubey S.... Desouza A.C.	2009	F5
4	Hereditary thrombocytopenia and acute myeloid leukemi a: a common link due to a germline mutation in the AML1 gene. (19337732)	Appelmann I.... Mesters R.M.	2009	RUNX1
5	Serologic results in >1000 patients with suspected heparin-induced thrombocytopenia. (17895512)	Shelat S.G.... Pollak E.S.	2008	PF4
6	Heparin-induced thrombocytopenia complicated by warfa rin-induced skin necrosis. (18541684)	Howard-Thompson A.... Finch C.K.	2008	PF4
7	MBL2 gene polymorphisms protect against development of thrombocytopenia associated with severe dengue phenotype. (18361938)	Acioli-Santos B.... Crovella S.	2008	MBL2
8	Inflammation induces hemorrhage in thrombocytopenia. (18256319)	Goerge T.... Wagner D.D.	2008	GP1BA, RAPGEF3, RASGRP2
9	Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice. (17625608)	Lehmann S.... Koeffler H.P.	2007	RPS14, G3BP1, TNIP1
10	Heparin induced thrombocytopenia: pathogenetic, clinical, diagnostic and therapeutic aspects. (17896955)	Castelli R.... Fabris F.	2007	PF4
11	Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. (16304054)	Rauova L.... Poncz M.	2006	PF4
12	MPL mutations in 23 patients suffering from congenital amegakaryocytic thrombocytopenia: the type of mutation predicts the course of the disease. (16470591)	Germeshausen M.... Welte K.	2006	MPL
13	Thrombopoietin in postoperative thrombocytopenia following living donor hepatectomy. (16498650)	Nagasako Y.... Todo S.	2006	THPO
14	A splenectomy in plasma exchange refractory thrombotic thrombocytopenia purpura. (18156712)	Lee Y.J.... Park D.E.	2006	VWF
15	Approaches to anemia, thrombocytopenia, and DIC in c ancer patients (16410690)	Matsushita T.	2006	EPO
16	HOXA11 mutation in amegakaryocytic thrombocytopenia with radio-ulnar synostosis syndrome inhibits megakaryocytic differentiation in vitro. (16765069)	Horvat-Switzer R.D.... Thompson A.A.	2006	HOXA11
17	Inherited thrombocytopenia: Congenital amegakaryocytic thrombocytopenia and thrombocytopenia with absent radii. (16822462)	Geddis A.E.	2006	THPO, MPL
18	A multi-center clinical trial of recombinant human thrombopoietin in the treatment of chemotherapy-induced thrombocytopenia in patients with solid tumor (15379272)	Bai C.M.... Shan Y.D.	2004	THPO
19	Thrombopoietin (TPO) levels in hepatic patients with thrombocytopenia. (15763973)	Aref S.... Khafagy N.	2004	THPO
20	Three parameters, plasma thrombopoietin levels, plasma glycocalicin levels and megakaryocyte culture, distinguish between different causes of congenital thrombocytopenia. (11972523)	van den Oudenrijn S.... von dem Borne A.E.	2002	THPO, GP1BA
21	Prevalence, isotype, and functionality of antiheparin-platelet factor 4 antibodies in patients treated with heparin and clinically suspected for heparin-induced thrombocytopenia. The pathogenic role of IgG. (11958801)	Untch B.... Fareed J.	2002	SELP, CD40LG
22	Missense mutations of the WASP gene cause intermittent X-linked thrombocytopenia. (11877312)	Notarangelo L.D.... Notarangelo L.D.	2002	WAS
23	Extensive life-threatening thrombosis in a patient with heparin-induced thrombocytopenia and factor V Leiden mutation. (11532640)	Pizzolo F.... Olivieri O.	2001	F5
24	Is the thrombopoietin assay useful for differential diagnosis of thrombocytopenia? Analysis of a cohort of 160 patients with thrombocytopenia and defined platelet life span. (11514400)	Gouin-Thibault I.... Schlageter M.H.	2001	THPO
25	Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. (11682618)	Wang Z.... Melmed S.	2001	PTTG1
26	Heparin-induced thrombocytopenia: natural history, diagnosis, and management. (11530963)	Deitcher S.R.... Carman T.L.	2001	PF4
27	Screening for c-mpl mutations in patients with congenital amegakaryocytic thrombocytopenia identifies a polymorphism. (11392330)	van den Oudenrijn S.... von dem Borne A.E.	2001	MPL
28	Thrombopoietic effect of recombinant human thrombopo ietin gene transferred to mice mediated by electric pulse on normal and experim ental thrombocytopenia mice (11877062)	Zang W.... Wang D.	2001	THPO
29	A new approach in the study of the molecular and cellular events implicated in heparin-induced thrombocytopenia. Formation of leukocyte-platelet aggregates. (11434690)	Khairy M.... Bachelot-Loza C.	2001	SELP, FCGR2A
30	Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: evidence for decreased platelet production. (11091188)	Sosman J.A.... Hoffman R.	2000	IL10
31	Thrombopoietin induces rapid resolution of thrombocytopenia after orthotopic liver transplantation through increased platelet production. (10648388)	Peck-Radosavljevic M.... Gangl A.	2000	THPO
32	Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation. (10205219)	Goulis J.... Burroughs A.K.	1999	THPO
33	Lepirudin (recombinant hirudin) for parenteral antico agulation in patients with heparin-induced thrombocytopenia. Heparin-Associated Thrombocytopenia Study (HAT) investigators. (10441094)	Greinacher A.... Luz M.	1999	F3
34	Factor V Leiden and thrombotic complications in heparin-induced thrombocytopenia. (9459322)	Lee D.H.... Kelton J.G.	1998	F5
35	Glycocalicin in the diagnosis and management of immun e thrombocytopenia. (9714518)	Steffan A.... Fabris F.	1998	GP1BA
36	Flow cytometric detection of circulating activated platelets in primary antiphospholipid syndrome. Correlation with thrombocytopenia and anticardiolipin antibodies. (9104734)	Fanelli A.... Emmi L.	1997	APOH
37	Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver? (9252085)	Peck-Radosavljevic M.... Gangl A.	1997	THPO
38	Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production. (8896400)	Chang M.... Cairo M.S.	1996	THPO, IL11
39	Thrombocytopenia after high-dose chemotherapy and autologous stem cell transplantation: an unresolved problem and possible approaches to resolve it. (8877716)	Hassan H.T.... Zander A.R.	1996	IL3, IL11
40	The thrombocytopenia of cancer. Prospects for effective cytokine therapy. (8707763)	Kaushansky K.	1996	IL11
41	Amifostine and chemotherapy-related thrombocytopenia. (8783667)	Budd G.T.	1996	IL3, CSF2, CSF3
42	Monoclonal antibody 197 (anti-Fc gamma RI) infusion i n a patient with immune thrombocytopenia purpura (ITP) results in down-modulati on of Fc gamma RI on circulating monocytes. (8616043)	Ericson S.G.... Ely P.	1996	FCGR1A
43	Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia. (8826901)	Akahori H.... Miyazaki H.	1996	THPO
44	Prolonged thrombocytopenia after administration of granulocyte colony-stimulating factor and leukapheresis in a donor for allogeneic peripheral blood stem cell transplantation. (8864472)	Okamoto S.... Ikeda Y.	1996	CSF3
45	Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. (8639762)	Emmons R.V.... Shulman N.R.	1996	THPO
46	Varicella-associated thrombocytopenia: autoantibodies against platelet surface glycoprotein V. (8888292)	Mayer J.L.... Beardsley D.S.	1996	GP5
47	Evaluation of murine leukemia virus infection as a model for thrombocytopenia of HIV/AIDS: mechanism of thrombocytopenia and modulation of thrombocytopenia by thrombopoietin. (7546911)	Sullivan P.S.... McDonald T.P.	1995	THPO
48	Transient thrombocytopenia after the administration of granulocyte colony-stimulating factor in a patient with acute agranulocytosis (7685928)	Antich Rojas J.L.... SantamarA-a SemA-s J.	1993	CSF3
49	Characterization of platelet activation induced by HL A antibodies associated with alloimmune thrombocytopenia. (7680369)	Christie D.J.... Swinehart C.D.	1993	SELP
50	Effect of a factor VIII concentrate on type IIB von Willebrand's disease-associated thrombocytopenia presenting during pregnancy in identical twin mothers. (2117853)	Ieko M.... Nakagawa S.	1990	VWF

Genes related to thrombocytopenia according to GeneCards:

(show top 50)    (show all 170)

id	Symbol	Description	Score	GeneCards Section Context
1	GATA1	GATA binding protein 1 (globin transcription factor 1)	11.1	Summaries, Publications
2	WAS	Wiskott-Aldrich syndrome	11.1	Publications, Aliases & Descriptions, Orthologs
3	MASTL	microtubule associated serine/threonine kinase-like	11.1	Summaries, Publications
4	HOXA11	homeobox A11	11.1	Summaries, Publications
5	ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	11.1	Publications, Summaries
6	THC2	thrombocytopenia 2 (autosomal dominant)	11.0	Publications, Aliases & Descriptions
7	CYCS	cytochrome c, somatic	11.0	Publications, Summaries
8	TCPT	thrombocytopenia, Paris-Trousseau type	11.0	Aliases & Descriptions
9	TAR	Thrombocytopenia-absent radius syndrome	11.0	Aliases & Descriptions
10	ANKRD26	ankyrin repeat domain 26	11.0	Publications, Summaries
11	CFI	complement factor I	11.0	Summaries
12	THPO	thrombopoietin	11.0	Publications
13	MPL	myeloproliferative leukemia virus oncogene	11.0	Publications
14	ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	11.0	UniProt Related, Publications
15	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	11.0	Publications, Functions
16	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
17	IL11	interleukin 11	11.0	Publications, UniProt Related
18	GP5	glycoprotein V (platelet)	11.0	Publications
19	ZFPM1	zinc finger protein, multitype 1	11.0	Publications
20	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
21	PF4	platelet factor 4	11.0	Publications
22	ZNF85	zinc finger protein 85	11.0	Publications
23	TNXA	tenascin XA (pseudogene)	11.0	Publications
24	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.0	Publications
25	AZU1	azurocidin 1	11.0	Publications
26	MMRN1	multimerin 1	11.0	Publications
27	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
28	FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	11.0	Publications
29	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
30	POU2F3	POU class 2 homeobox 3	11.0	Publications
31	CD40LG	CD40 ligand	11.0	Publications
32	F10	coagulation factor X	11.0	Publications
33	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
34	FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	11.0	Publications
35	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
36	THBD	thrombomodulin	11.0	Publications
37	F2	coagulation factor II (thrombin)	11.0	Publications
38	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
39	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
40	GP1BB	glycoprotein Ib (platelet), beta polypeptide	11.0	Publications
41	GP9	glycoprotein IX (platelet)	11.0	Publications
42	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	11.0	Publications, UniProt Related
43	HOXA10	homeobox A10	11.0	Publications
44	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif, 13	11.0	Publications
45	FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	11.0	Publications
46	IL18R1	interleukin 18 receptor 1	11.0	Publications
47	MYH9	myosin, heavy chain 9, non-muscle	11.0	Publications
48	IGSF3	immunoglobulin superfamily, member 3	11.0	Publications
49	PECAM1	platelet/endothelial cell adhesion molecule 1	11.0	Publications
50	ALOX12	arachidonate 12-lipoxygenase	11.0	Publications

Pathways related to thrombocytopenia according to GeneDecks:

(show top 50)    (show all 131)

id	Pathway	Score	Top Affiliating Genes
1	Staphylococcus aureus infection20	INF	, HLA-DRB3, ICAM1, MBL2, IL10, SELP
2	Blood Coagulation Signaling Pathways37	11.0	SERPINE1, SERPINC1, VWF, GP5, GP9, PROC
3	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	10.8	F2R, PLCG2, F2, GP6, GP1BB, GP9
4	RAR-Gamma-RXR-Alpha Degradation36	10.5	CSF3, CSF2, CSF1, PF4, TNFSF13B, TNFSF13
5	Glioma Invasiveness36	10.3	KITLG, BMP6, CD44, IL3, THPO, PPBP
6	Cell surface interactions at the vascular wall38	10.2	ITGAL, ITGB2, ANGPT1, GP6, F2, THBD
7	Regulation of eIF4 and p70S6K36	10.2	ITGB3, ITGB2, ITGAM, ITGAL, ITGA2B, ITGA2
8	Bacterial infections in CF airways41	10.2	TLR2, TLR5, IL1R1
9	NFAT Signaling and Lymphocyte Interactions36	10.0	IL1A, IL11, BMP6, IL22, IL3, ANGPT1
10	Jak-STAT signaling pathway20	10.0	MPL, IL10, IL11, IL11RA, IL2, IL21
11	PPAR Pathway36	9.9	IL2, KITLG, RAF1, ITGA2, ITGA2B, TNF
12	Hematopoietic cell lineage20	9.7	THPO, TNF, HLA-DRB3, GP1BB, GP1BA, GP9
13	Akt Signaling36	9.5	THPO, CXCL10, CSF1, CSF2, PF4, TNFSF13B
14	PGC1Alpha Pathway36	9.2	BMP6, TNFSF10, TNFRSF17, IL8, IL3, IL22
15	IL-6 Pathway36	9.0	IL3, IL8, ANGPT1, HRAS, TNFSF10, TNFSF13
16	Th17 Differentiation37	9.0	IL17A, IL17F, IL1B, IL1R1, TGFB1, IL21
17	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.8	IFNG, TLR4, TLR5, TGFB1, IL17A, TLR2
18	Amoebiasis20	8.7	ITGAM, TGFB1, TLR4, TLR2, IL8, IL6
19	Molecular Mechanisms of Cancer36	8.7	RASGRP2, CASP3, CDKN1A, CDKN2B, CDKN1B, ITGA2
20	Natural killer cell mediated cytotoxicity20	8.6	RAF1, IFNA2, FASLG, FCGR3A, IFNA1, ITGAL
21	Endothelin-1 Signaling Pathway36	8.6	PF4, EDN1, CXCL10, CSF1, CSF3, TNFSF13B
22	ERK Signaling36	8.5	KITLG, BMP6, RAF1, ITGA2B, ITGAL, ITGAM
23	African trypanosomiasis20	8.4	IL6, FASLG, IFNG, IL1B, IL18, IL10
24	Cytokine Network36	8.3	IL10, IL8, IFNA1, IFNA2, IFNG, IL6
25	all-trans-Retinoic Acid Signaling in Brain36	8.1	BMP6, IL10, IL11, IL18, IL1A, IL1B
26	MIF Mediated Glucocorticoid Regulation36	8.1	BMP6, IL10, IL11, IL18, IL1A, IL1B
27	TGF-Beta Pathway36	8.1	IL22, IL3, IL6, IL8, ANGPT1, HRAS
28	MIF Regulation of Innate Immune Cells36	8.1	PF4, TNF, ANGPT1, IL8, IL6, IL3
29	Rho Family GTPases36	8.1	TNFSF13B, IL10, ITGB3, ITGB2, ITGAM, ITGAL
30	PEDF Induced Signaling36	8.0	CSF1, CXCL10, PF4, TNFSF13B, TNFSF13, TNFSF10
31	Influenza A20	7.9	IL6, IL8, FASLG, FAS, IFNA1, CYCS
32	MAPK Family Pathway36	7.8	HRAS, ANGPT1, IL8, IL6, IL3, IL22
33	Glucocorticoid Receptor Signaling36	7.8	TGFB1, TNFRSF17, IL1B, IL1A, IL18R1, TNFSF13B
34	STAT3 Pathway36	7.8	CSF2, CSF1, CXCL10, PF4, TNFSF13B, TNFSF13
35	JAK-STAT Pathway36	7.8	HRAS, F2R, F2, IFNG, IFNA2, IFNA1
36	SOCS Pathway36	7.7	IL10, IL11, IL18, IL1A, IL1B, BMP6
37	PAK Pathway36	7.5	IL3, IL22, IL21, IL2, IL1B, IL1A
38	Rheumatoid arthritis20	7.5	CSF2, IL6, IL1B, IL1A, IL18, IL17A
39	Malaria20	7.4	PECAM1, CSF3, TGFB1, TLR4, TLR2, TNF
40	p38 Signaling36	7.3	PF4, PLCG2, PPBP, TNFSF13B, TNFSF13, TNFSF10
41	Cytokine-cytokine receptor interaction20	7.3	CSF3, CSF2, CSF1, CXCL10, TGFB1, PF4
42	Antioxidant Action of Vitamin-C36	7.0	CSF3, MYH9, CSF2, IL22, IL3, IL6
43	Chagas disease (American trypanosomiasis)20	INF	TLR4, IL2, IL1B, IL10, SERPINE1, FASLG
44	Leishmaniasis20	INF	, ITGB2, ITGAM, FCGR1A, FCGR2A, TGFB1
45	Phagocytosis of Microbes36	INF	ITGAM, , TLR5, TLR4, TLR2, PLCG2
46	Measles20	INF	IFNA1, IFNG, TNFSF10, FASLG, TLR2, TLR4
47	Tuberculosis20	INF	IL10, FCGR3A, FCGR2B, FCGR2A, FCGR1A, ITGB2
48	Tec Kinases Signaling36	INF	PLCG2, PPBP, TNFSF13B, TNFSF10, TNFRSF17, ANGPT1
49	Phospholipase-C Pathway36	INF	ITGA2B, BMP6, CD79A, RAF1, ITGA2, FCGR2A
50	Complement and coagulation cascades20	INF	, PROC, THBD, PLAT, F10, F2R

Compounds related to thrombocytopenia according to GeneDecks:

(show top 50)    (show all 511)

id	Compound	Score	Top Affiliating Genes
1	mannose32	INF	RECK, CD79A, CD9, , ITGAL, ITGAM
2	folate32	INF	RECK, VWF, SELE, SERPINC1, MTHFR, CD79A
3	glucose32	INF	RAPGEF3, , ITGA2, MGMT, IL11, IL18R1
4	ionomycin32	11.0	WAS, CD70, IL3, CSF2
5	ristocetin32	10.8	RECK, VWF, SELP, SERPINC1, GP9, GP1BA
6	nicotine32 34 9 9	13.7	SELL, GPT, SLC17A5
7	ppack32	10.5	VWF, SELP, SERPINC1, CD36, CD40LG, F3
8	tirofiban32 9 9	12.4	VWF, SELP, SERPINC1, CD40LG, ITGA2, ITGA2B
9	ptca32	10.4	PIK3C2A, SELP, ITGAM, ITGB2, APOH, F3
10	thromboxane a232 18	11.3	PIK3C2A, VWF, SELP, CD9, ITGA2, APOH
11	agar32	10.3	KITLG, CDKN1B, CD40LG, HRAS, PF4, THPO
12	silicone32	10.3	SELE, SERPINC1, CD79A, CD36, CD40LG, ITGB2
13	sp 60012532 42	11.1	CDKN1A, IL17A, CASP3, CYCS, TLR2
14	ascorbic acid32 18	11.0	RAF1, CD36, CD40LG, CD9, ITGAM, IL1A
15	ethanol32 34 9 18 9	13.9	KITLG, BCHE, AZU1, ITGAL, ITGAM, ITGB2
16	fucoidan32	9.9	SELE, SELL, SELP, SERPINC1, SERPINE1, AZU1
17	dextran sulfate32	9.9	SELE, SELL, SELP, SERPINC1, CD36, CD40LG
18	pge232	9.8	SELE, RAF1, FCGR1A, IL17A, IL1A, IL1R1
19	12-o-tetradecanoylphorbol 13-acetate32	9.7	BMP6, RAF1, CDKN1A, CDKN1B, CD44, CD9
20	adenylate32	9.2	KITLG, VWF, SELE, SELP, SERPINC1, SERPINE1
21	latex32	9.0	WAS, WASL, KITLG, VWF, CD44, CD9
22	groalpha32	8.9	SELE, IL10, IL17A, IL18, IL1A, IL1B
23	calcitriol32 42 9 18 9	12.9	KITLG, BMP6, CFI, CDKN1A, CD36, CDKN1B
24	matrigel32	8.8	VWF, SELE, SERPINE1, BMP6, CD36, CD44
25	adalimumab32 9 9	10.5	CD79A, FCGR1A, FCGR2A, FCGR2B, FCGR3A, IL10
26	polyinosinic-polycytidylic acid32	8.3	SELE, IL10, IL18, IL2, IL6, IL8
27	wortmannin32 42	9.2	PIK3C2A, WAS, KITLG, RAF1, CDKN1A, CDKN1B
28	sb 20358032 42	9.2	SELE, BMP6, CDKN1A, CD36, CDKN1B, ITGAM
29	lipoteichoic acid32	8.0	SELE, IL10, IL18, IL1B, IL1R1, IL1RN
30	il-1232	8.0	CD40LG, IL10, IL18, IL1B, IL1R1, IL2
31	superoxide32 18	8.9	PIK3C2A, KITLG, SELL, AZU1, ITGAL, ITGAM
32	poly(i-c)32	7.8	IL18, IL1B, IL3, IL6, IL8, IFNA1
33	prednisolone32 9 9	9.3	PIK3C2A, KITLG, VWF, SELL, BMP6, CD79A
34	tacrolimus32 34 9 9	10.2	SERPINE1, BMP6, RAF1, CFH, CD79A, CD36
35	butyrate32	7.0	KITLG, MYB, BMP6, RAF1, BCHE, CDKN1A
36	hydrocortisone32 9 9	8.6	KITLG, BMP6, CD36, INS, IL10, IL1A
37	genistein32 9 18 9	9.5	KITLG, SELE, SELL, SELP, SERPINE1, RAF1
38	retinoic acid32 42 18	7.3	KITLG, VWF, SELL, SELP, SERPINE1, MYB
39	estrogen32	INF	VWF, SERPINC1, SERPINE1, RAF1, MTHFR, CFI
40	tamoxifen32 34 9 9	INF	SELE, SERPINC1, BMP6, RAF1, CDKN1A, CDKN1B
41	paraffin32	INF	KITLG, VWF, SELL, MS4A1, CD79A, CDKN1A
42	lactate32	INF	PIK3C2A, RECK, KITLG, VWF, SELE, SELL
43	nitric oxide32 9 18 9	INF	KITLG, SELE, SELP, BMP6, CDKN1B, CD44
44	lipid32	INF	PIK3C2A, RECK, WAS, WASL, KITLG, SELE
45	sialic acid32	INF	RECK, SELL, CFH, CD79A, CD44,
46	actinomycin d32	INF	KITLG, SELE, SERPINE1, MYB, CDKN1A, CDKN1B
47	prostacyclin32	INF	PIK3C2A, VWF, SELE, SELP, SERPINC1, SERPINE1
48	5fluorouracil32	INF	KITLG, SELE, MTHFR, MPL, CDKN1A, CD36
49	adp32 18	INF	PIK3C2A, RECK, WAS, WASL, VWF,
50	oxygen32 18	INF	PIK3C2A, KITLG, MYB, BCHE, CDKN1A, CDKN1B

Cellular components related to thrombocytopenia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	INF	IL6, CFI, , CFH, , AZU1
2	integral to plasma membrane	GO:005887	INF	F2R, ICAM1, GP6, GP1BB, GP1BA, GP9
3	integrin complex	GO:008305	10.4	ITGB3, ITGB2, ITGAM, ITGAL, ITGA2B, ITGA2
4	platelet alpha granule membrane	GO:031092	10.3	PECAM1, ITGB3, ITGA2B, CD9, CD36, SELP
5	platelet alpha granule lumen	GO:031093	9.9	TGFB1, PF4, PPBP, SPARC, ALB, F5
6	external side of plasma membrane	GO:009897	8.2	CXCL10, CD9, CD44, CD40LG, CD36, CD79A
7	extracellular space	GO:005615	INF	EPO, ADAMTS13, , PPBP, SPARC, TNFSF13B
8	plasma membrane	GO:005886	INF	HRAS, FAS, , IL1RN, IL1R1, IL18R1

Biological processes related to thrombocytopenia according to GeneDecks:

(show top 50)    (show all 53)

id	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:006955	INF	, CSF3, CSF2, CXCL10, TLR4, TLR2
2	signal transduction	GO:007165	INF	ANXA5, HRAS, HLA-DRB3, TNFRSF17, TNFSF10, TNFSF13
3	blood coagulation, intrinsic pathway	GO:007597	11.1	F10, F2, F9, GP1BB, GP1BA, GP9
4	embryonic hemopoiesis	GO:035162	10.9	GATA1, RUNX1, IL3, ZFPM1, KITLG, KLF1
5	positive regulation of blood coagulation	GO:030194	10.8	HPSE, F2R, F2, APOH, CD36, SERPINE1
6	integrin-mediated signaling pathway	GO:007229	10.8	MYH9, ADAMTS13, ITGB3, ITGB2, ITGAM, ITGAL
7	defense response to Gram-negative bacterium	GO:050829	10.7	TLR4, IL6, AZU1, SERPINE1, SELP
8	cell-matrix adhesion	GO:007160	10.7	ADAMTS13, HPSE, GP5, ITGB3, ITGB2, ITGA2B
9	leukocyte cell-cell adhesion	GO:007159	10.5	TNIP1, ICAM1, ITGB2, ITGAL, CD40LG, SELP
10	response to lipopolysaccharide	GO:032496	10.3	SELE, EDN1, PLCG2, SPARC, F2R, F3
11	cell adhesion	GO:007155	10.2	GP9, GP5, IL2, MMRN1, GP1BA, GP1BB
12	positive regulation of inflammatory response	GO:050729	10.2	TLR4, TLR2, TNIP1, IL21, IL2, IL18
13	leukocyte migration	GO:050900	10.1	MYH9, SIRPA, PECAM1, PROC, THBD, HRAS
14	platelet activation	GO:030168	10.1	F2R, F2, F5, GP6, GP1BB, GP1BA
15	positive regulation of MHC class II biosynthetic process	GO:045348	10.1	TLR4, IFNG, IL10, CD40LG, AZU1
16	negative regulation of lipid storage	GO:010888	10.0	CRP, TNF, IL6, ITGB3
17	positive regulation of chemokine production	GO:032722	10.0	TLR4, TLR2, TNF, IL6, IL18
18	platelet degranulation	GO:002576	10.0	PECAM1, SERPINE1, SELP, VWF, CD36, CD9
19	positive regulation of interleukin-8 production	GO:032757	9.9	TLR5, TLR4, TLR2, IL1B, IL18, SERPINE1
20	cell surface receptor signaling pathway	GO:007166	9.8	CXCL10, EDN1, HRAS, F2, IFNG, IFNA2
21	positive regulation of interleukin-12 production	GO:032735	9.8	TLR4, TLR2, IDO1, IFNG, CD40LG, CD36
22	positive regulation of interferon-gamma production	GO:032729	9.7	TLR4, TNF, IL2, IL1B, IL18, CD40LG
23	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.7	IL6, ANGPT1, TLR4, GATA1, IL3, IL11
24	regulation of sensory perception of pain	GO:051930	9.7	EDN1, F2R, IL1A, IL10, TLR4
25	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.7	TGFB1, TNF, ANGPT1, IL6, IL11, CD44
26	positive regulation of tumor necrosis factor production	GO:032760	9.6	CD36, IL18, IFNG, PF4, TLR2, TLR4
27	positive regulation of interleukin-6 production	GO:032755	9.6	TLR4, TLR2, TNF, IL6, IL1B, IL1A
28	positive regulation of DNA replication	GO:045740	9.4	EPO, CSF2, HRAS, IL3, INS, KITLG
29	acute-phase response	GO:006953	9.3	CRP, F2, MBL2, IL6, IL22, IL1RN
30	lipopolysaccharide-mediated signaling pathway	GO:031663	9.2	TGFB1, TLR4, TLR2, TNF, IL1B, IL18
31	response to glucocorticoid stimulus	GO:051384	9.1	TAT, PLAT, SPARC, TNF, FAS, IL6
32	cellular response to organic cyclic compound	GO:071407	9.1	TGFB1, TNF, IL1B, IL18, CDKN1B, MGMT
33	negative regulation of growth of symbiont in host	GO:044130	9.1	TLR2, TNF, IFNG, MBL2, IL10, CD36
34	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.1	TLR4, TNF, HRAS, F2R, ANGPT1, IL1B
35	positive regulation of protein kinase B signaling cascade	GO:051897	8.9	TGFB1, TNF, HPSE, F10, F3, ANGPT1
36	positive regulation of cell proliferation	GO:008284	8.8	TNFSF13, TNFSF13B, EDN1, THPO, TGFB1, CXCL10
37	cellular response to lipopolysaccharide	GO:071222	8.7	SERPINE1, CD36, IL10, IL8, IFNG, ICAM1
38	negative regulation of apoptotic process	GO:043066	8.6	CASP3, TNF, PF4, PROC, CSF2, EPO
39	cell-cell signaling	GO:007267	8.5	IL3, FASLG, IFNA2, TNFSF10, EDN1, CXCL10
40	response to hypoxia	GO:001666	8.5	CRP, PLAT, EDN1, TLR4, TGFB1, TNF
41	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.1	IFNG, HRAS, TNF, TNIP1, TLR2, TLR4
42	negative regulation of cell proliferation	GO:008285	8.1	F2R, HRAS, TNF, PTTG1, TGFB1, GATA1
43	positive regulation of nitric oxide biosynthetic process	GO:045429	8.0	TLR4, TLR2, EDN1, TNF, ICAM1, IFNG
44	regulation of complement activation	GO:030449	INF	, , CFI, CFH,
45	inflammatory response	GO:006954	INF	IL8, IL6, IL22, IL1B, IL1A, IL18
46	anti-apoptosis	GO:006916	INF	ANXA5, ANGPT1, F3, ALOX12, TNF, EPO
47	induction of apoptosis	GO:006917	INF	TGFB1, TLR2, TNFSF10, TNF, CASP3, IFNA2
48	blood coagulation	GO:007596	INF	PROC, F2R, F2, F3, F5, F9
49	negative regulation of blood coagulation	GO:030195	INF	PROC, THBD, EDN1, APOH, , SERPINE1
50	positive regulation vascular endothelial growth factor production	GO:010575	INF	, TGFB1, HPSE, IL1B, IL1A

Molecular functions related to thrombocytopenia according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	TNFSF10, TGFB1, , PROC, CSF2, POU2F3
2	glycoprotein binding	GO:001948	9.9	FLNA, ITGB2, ITGAM, SELP, VWF, APOH
3	eukaryotic cell surface binding	GO:043499	9.9	EPO, TGFB1, ANXA5, MBL2, APOH, SELP
4	transmembrane signaling receptor activity	GO:004888	9.8	THBD, TLR4, TLR2, ICAM1, GP6, GP1BB
5	tumor necrosis factor receptor binding	GO:005164	9.8	TNFSF13B, TNFSF13, TNFSF10, TNF, FASLG, CD40LG
6	protease binding	GO:002020	9.3	TNF, F3, IL1R1, INS, CD70, SERPINE1
7	growth factor activity	GO:008083	9.2	PPBP, THPO, TGFB1, CSF1, CSF2, CSF3
8	cytokine activity	GO:005125	7.9	IL3, IL6, FASLG, IFNA2, IFNG, TNF
9	receptor binding	GO:005102	INF	GBA, , CXCL10, TNFSF13B, TNFSF13, TNFSF10