ITP
MCID: THR001
MIFTS: 42

Thrombocytopenia Due to Platelet Alloimmunization (ITP) malady

Categories: Rare diseases, Blood diseases, Immune diseases, Genetic diseases

Aliases & Classifications for Thrombocytopenia Due to Platelet Alloimmunization

Aliases & Descriptions for Thrombocytopenia Due to Platelet Alloimmunization:

Name: Thrombocytopenia Due to Platelet Alloimmunization 12 14 69
Autoimmune Thrombocytopenia 25 29 52 69
Immune Thrombocytopenia 12 50 25
Immune Thrombocytopenic Purpura 25 69
Thrombocytopenia Due to Immune Destruction 12
Autoimmune Thrombocytopenic Purpura 25
Idiopathic Thrombocytopenic Purpura 25
Auto-Immune Thrombocytopenia 12
Werlhof Disease 25
Itp 25

Classifications:



External Ids:

Disease Ontology 12 DOID:1587
NCIt 47 C3991
SNOMED-CT 64 2897005
UMLS 69 C0272286

Summaries for Thrombocytopenia Due to Platelet Alloimmunization

Genetics Home Reference : 25 Immune thrombocytopenia is a disorder characterized by a blood abnormality called thrombocytopenia, which is a shortage of blood cell fragments called platelets that are involved in clotting.

MalaCards based summary : Thrombocytopenia Due to Platelet Alloimmunization, also known as autoimmune thrombocytopenia, is related to autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome and thrombocytopenic purpura, autoimmune. An important gene associated with Thrombocytopenia Due to Platelet Alloimmunization is ITGA2B (Integrin Subunit Alpha 2b), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Regulation of actin cytoskeleton. The drugs Amodiaquine and Artemether have been mentioned in the context of this disorder. Related phenotypes are hematopoietic system and cellular

Related Diseases for Thrombocytopenia Due to Platelet Alloimmunization

Diseases in the Thrombocytopenia family:

Thrombocytopenia 4 Thrombocytopenia 2
Thrombocytopenia 5 Acquired Thrombocytopenia
Thrombocytopenia Due to Platelet Alloimmunization Primary Thrombocytopenia
Myh9 Related Thrombocytopenia Mastl-Related Thrombocytopenia 2
Gata1-Related Thrombocytopenia Thrombocytopenia 6

Diseases related to Thrombocytopenia Due to Platelet Alloimmunization via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
id Related Disease Score Top Affiliating Genes
1 autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome 11.9
2 thrombocytopenic purpura, autoimmune 11.2
3 ectodermal dysplasia, ectrodactyly, and macular dystrophy 10.2 MPL THPO
4 thrombocytopenia, congenital amegakaryocytic 10.2 MPL THPO
5 early-onset anterior polar cataract 10.2 MPL THPO
6 subclavian artery aneurysm 10.2 ITGA2B SELP
7 chronic inflammatory demyelinating polyneuritis 10.1 CD40LG THPO
8 lupus erythematosus 10.1 ITGA2B SELP
9 middle cerebral artery infarction 10.1 ITGA2B THPO
10 essential thrombocythemia 10.1 GP9 ITGA2B
11 thunderclap headache 10.1 ITGA2 ITGA2B
12 hereditary endotheliopathy, retinopathy, nephropathy, and stroke 10.1 CD40LG SELP
13 fetal macrosomia 10.1 ITGA2 ITGA2B
14 prostatic cyst 10.1 ITGA2B THPO
15 blood coagulation disease 10.1 MPL THPO
16 bulbospinal polio 10.0 CD40LG ITGA2B THPO
17 facial dysmorphism-anorexia-cachexia-eye and skin anomalies syndrome 10.0 ITGA2B MYH9
18 hyperparathyroidism, neonatal 10.0 ITGA2B MPL THPO
19 granulomatous hepatitis 10.0 MPL SELP THPO
20 membranoproliferative glomerulonephritis 10.0 CD40LG ITGA2B THPO
21 hypertrophic elongation of cervix 10.0 CD40LG ITGA2B
22 hidrocystoma 10.0 CD40LG ITGA2
23 ametropic amblyopia 10.0 CD40LG MYH9
24 cerebral neuroblastoma 10.0 CD40LG MYH9
25 adrenal gland disease 10.0 CD40LG MYH9
26 atypical breast papilloma 10.0 CD40LG MYH9
27 placental insufficiency 10.0 CD40LG ITGA2
28 dentinogenesis imperfecta 10.0 CD40LG THPO
29 muscular dystrophy 10.0 CD40LG MYH9
30 dysplastic nevus syndrome 9.9 CD40LG MYH9
31 osteogenesis imperfecta, type vii 9.9 CD40LG GP9 SELP
32 benjamin syndrome 9.9 CD40LG MYH9
33 pseudohypoparathyroidism 9.9 CD40LG MYH9
34 immunodeficiency 20 9.9 ITGA2B MPL SELP THPO
35 basilar artery insufficiency 9.9 ITGA2B MPL SELP THPO
36 immunoglobulin g deficiency 9.9 CD40LG THPO
37 gluten allergy 9.9 CD40LG ITGA2B MPL THPO
38 perichondritis of auricle 9.9 CD40LG ITGA2B MPL THPO
39 cadasil 9.8
40 thrombocytopenia 9.8
41 pyridoxamine 5'-phosphate oxidase deficiency 9.8 GP9 ITGA2 ITGA2B SELP
42 severe nonproliferative diabetic retinopathy 9.7 CD40LG ITGA2B MPL SELP THPO
43 haemonchiasis 9.6 CD40LG ITGA2 ITGA2B MPL THPO
44 ocular hyperemia 9.5 CD40LG GP9 ITGA2B MPL SELP THPO
45 immunodeficiency 21 9.5 GP9 ITGA2 ITGA2B MYH9 THPO
46 tracheal disease 9.3 GP9 ITGA2 ITGA2B MPL MYH9 THPO
47 myeloproliferative neoplasm 9.2 CD40LG GP9 ITGA2B MPL MYH9 SELP
48 mental depression 8.9 CD40LG GP9 ITGA2 ITGA2B MPL MYH9

Graphical network of the top 20 diseases related to Thrombocytopenia Due to Platelet Alloimmunization:



Diseases related to Thrombocytopenia Due to Platelet Alloimmunization

Symptoms & Phenotypes for Thrombocytopenia Due to Platelet Alloimmunization

MGI Mouse Phenotypes related to Thrombocytopenia Due to Platelet Alloimmunization:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 MYH9 SELP THPO CD40LG GP9 ITGA2
2 cellular MP:0005384 9.73 CD40LG ITGA2 ITGA2B MPL MYH9 SELP
3 homeostasis/metabolism MP:0005376 9.5 CD40LG ITGA2 ITGA2B MPL MYH9 SELP
4 immune system MP:0005387 9.1 CD40LG ITGA2B MPL MYH9 SELP THPO

Drugs & Therapeutics for Thrombocytopenia Due to Platelet Alloimmunization

Drugs for Thrombocytopenia Due to Platelet Alloimmunization (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 922)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amodiaquine Approved Phase 4 86-42-0 2165
2
Artemether Approved Phase 4,Phase 3 71963-77-4 119380 68911
3
Artesunate Approved Phase 4 88495-63-0 6917864 5464098
4
Lumefantrine Approved Phase 4,Phase 3 82186-77-4 6437380
5
Mefloquine Approved Phase 4 53230-10-7 4046
6
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
9
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2 50-28-2 5757 53477783
10
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
11
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
12
Norgestimate Approved Phase 4 35189-28-7 6540478
13
Pyrimethamine Approved, Vet_approved Phase 4,Phase 2 58-14-0 4993
14
Sulfadoxine Approved Phase 4,Phase 2 2447-57-6 17134
15
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3 148553-50-8 5486971
16
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
17
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
18
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Phase 1 81103-11-9 84029
19
Lansoprazole Approved, Investigational Phase 4,Phase 2 103577-45-3 3883
20
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
21
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
22
Acetaminophen Approved Phase 4,Phase 3,Phase 2 103-90-2 1983
23
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1 7440-66-6 32051 23994
24
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
25
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
26
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
27
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
28
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
29
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
30
Dinoprostone Approved Phase 4 363-24-6 5280360
31
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
32
Nepafenac Approved Phase 4 78281-72-8 151075
33
Ezetimibe Approved Phase 4 163222-33-1 150311
34
Simvastatin Approved Phase 4,Phase 3,Phase 1,Phase 2 79902-63-9 54454
35
Citalopram Approved Phase 4,Phase 3 59729-33-8 2771
36
Lopinavir Approved Phase 4 192725-17-0 92727
37
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
38
Pioglitazone Approved, Investigational Phase 4,Phase 2 111025-46-8 4829
39
Rosiglitazone Approved, Investigational Phase 4,Phase 1 122320-73-4 77999
40
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 772 46507594
41
Acetylcysteine Approved, Investigational Phase 4,Early Phase 1 616-91-1 12035
42
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
43
Yohimbine Approved, Vet_approved Phase 4 146-48-5 8969
44
Imipramine Approved Phase 4 50-49-7 3696
45
Ranibizumab Approved Phase 4,Phase 3,Phase 2 347396-82-1 459903
46
Desipramine Approved Phase 4,Phase 2,Phase 1 50-47-5 2995
47
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
48
Methamphetamine Approved, Illicit Phase 4,Phase 2,Phase 1 537-46-2 10836
49
Labetalol Approved Phase 4 36894-69-6 3869
50
Nicardipine Approved Phase 4,Phase 3 55985-32-5 4474

Interventional clinical trials:

(show top 50) (show all 1489)
id Name Status NCT ID Phase
1 Effectiveness of Artemisinin Combination Regimens in Falciparum Malaria Unknown status NCT00902811 Phase 4
2 Pain Evaluation During Follicle Aspiration: Comparison of Two Sedation Protocols Unknown status NCT00742807 Phase 4
3 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4
4 A Comparison of Prophylactic Antibacterial Efficacy of Besivance vs. VIGAMOX Prior to Cataract Surgery Unknown status NCT01296542 Phase 4
5 Aqueous Absorption and Pharmacokinetics of Besivance Versus VIGAMOX in Patients Undergoing Phacoemulsification Unknown status NCT01296191 Phase 4
6 Intermittent Antimalaria Treatment With SP in African Children Unknown status NCT00168948 Phase 4
7 tDCS as Add on Therapy for Treatment of Tobacco Dependence by Standardized Behaviour Therapy Unknown status NCT01729507 Phase 4
8 Efficacy and Safety of Amodiaquine and Amodiaquine-Artesunate Unknown status NCT00238017 Phase 4
9 Using Non-Fluoroscopic Imaging Devices to Decrease Radiation Exposure During Ablation of Supraventricular Tachycardia Unknown status NCT00979303 Phase 4
10 Effects of Pregabalin on Mechanical Hyperalgesia Unknown status NCT00310583 Phase 4
11 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Phase 4
12 Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura Completed NCT00467571 Phase 4
13 A Safety Study of Intravenous Immunoglobulin in Patients With Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT01390649 Phase 4
14 Platelet Function in Idiopathic Thrombocytopenic Purpura (ITP) Patients With Eltrombopag Completed NCT00888901 Phase 4
15 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
16 High-dose Dexamethasone Versus Conventional Dose Prednisone for Initial Treatment of Primary Immune Thrombocytopenia (ITP) Completed NCT01356511 Phase 4
17 A Comparison of Prostaglandin E2 (PGE2) Inhibition of Acuvail(Ketorolac 0.45%), Xibrom (Bromfenac 0.09%)and Nevanac (Nepafenac)in Patients Undergoing Phacoemulsification Completed NCT01021761 Phase 4
18 A Comparison of Peak Aqueous Penetration of Acuvail (Ketorolac 0.45%), Xibrom (Bromfenac 0.09%), and Nevanac (Nepafenac 0.1%)in Patients Undergoing Phacoemulsification Completed NCT01001806 Phase 4
19 The PostprAndial eNdothelial Function After Combination of Ezetimibe and simvAstatin Study Completed NCT00817843 Phase 4
20 Comparison of Rotating vs. Fixed Platform of the COLUMBUS Knee Prosthesis Completed NCT00822640 Phase 4
21 Treatment of Depression in Adults Completed NCT00073697 Phase 4
22 Raltegravir Kaletra Pharmacokinetics Completed NCT00564772 Phase 4
23 Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients: Trough Drug Effects Completed NCT00469690 Phase 4
24 Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease Completed NCT00534651 Phase 4
25 Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy Completed NCT01170754 Phase 4
26 A Comparison of Post Phacoemulsification Aqueous Flare in Patients Using Ketorolac 0.45% 2 Times Daily (BID) and Bromfenac 0.09% 2 Times Daily (BID) Completed NCT01023724 Phase 4
27 Effect of Thiazolidinedione Treatment Vascular Risk Markers Completed NCT00571506 Phase 4
28 Mechanism of Fatty Acid-induced Impairment of Glucose-simulated Insulin Secretion - Effect of Buphenyl Completed NCT00533559 Phase 4
29 Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated Insulin Secretion Completed NCT00188773 Phase 4
30 Mechanism of Growth Hormone Effects on Adipose Tissue Completed NCT00453557 Phase 4
31 "TAKE TIME" Pioglitazone Reverses Defects in Mitochondrial Biogenesis in Patients With T2DM Completed NCT00402012 Phase 4
32 Moxifloxacin vs. Polytrim for Conjunctivitis Completed NCT00581542 Phase 4
33 Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients Completed NCT00347503 Phase 4
34 Effects of Comorbid Personality Disorder on the Treatment of Bipolar I Disorder Completed NCT00178061 Phase 4
35 Bioequivalence Study Comparing Two Test Products With One Reference Product, All Containing 5 mg Yohimbine Completed NCT00975325 Phase 4
36 Oat Breakfast Satiety Study Completed NCT01372683 Phase 4
37 Psychosocial Therapy Plus Maintenance Pharmacotherapy for Treating Bipolar Disorder Completed NCT00227968 Phase 4
38 Comparing Various Treatments for Achieving and Maintaining Remission of Depression Completed NCT00227955 Phase 4
39 VEGF-antagonism and Endothelial Function in Age-related Macular Degeneration (AMD) Completed NCT00727753 Phase 4
40 Methamphetamine Abuse Treatment in Patients With AIDS - 1 Completed NCT00000321 Phase 4
41 Pharmacokinetic Study of Topically Applied Veregen 15% Compared With Oral Intake of Green Tea Beverage Completed NCT01082302 Phase 4
42 Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA) Completed NCT00094575 Phase 4
43 Xpert MTB/Rif, a New Tool for the Diagnosis of Pulmonary Tuberculosis in Two Municipalities in Brazil Completed NCT01363765 Phase 4
44 Effects of Ezetimibe on Postprandial Hyperlipidemia and Endothelial Function Completed NCT00189085 Phase 4
45 Is Omega-3 Fatty Acid Red Blood Cell (RBC) Saturation Product Dependent? Completed NCT01091714 Phase 4
46 Depression: The Search for Treatment-Relevant Phenotypes-Pilot Study Completed NCT00222820 Phase 4
47 Dry Age-Related Macular Degeneration (AMD) Treatment With Rheopheresis Trial Completed NCT00751361 Phase 4
48 Cryoplasty CLIMB-registry Completed NCT00459888 Phase 4
49 CAFE Study - Cancer Patient Fracture Evaluation Completed NCT00211237 Phase 4
50 Evaluation of Intravenous Cardene(Nicardipine)and Labetalol Use in the Emergency Department Completed NCT00765648 Phase 4

Search NIH Clinical Center for Thrombocytopenia Due to Platelet Alloimmunization

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Thrombocytopenia Due to Platelet Alloimmunization

Genetic tests related to Thrombocytopenia Due to Platelet Alloimmunization:

id Genetic test Affiliating Genes
1 Autoimmune Thrombocytopenia 29

Anatomical Context for Thrombocytopenia Due to Platelet Alloimmunization

Publications for Thrombocytopenia Due to Platelet Alloimmunization

Variations for Thrombocytopenia Due to Platelet Alloimmunization

Expression for Thrombocytopenia Due to Platelet Alloimmunization

Search GEO for disease gene expression data for Thrombocytopenia Due to Platelet Alloimmunization.

Pathways for Thrombocytopenia Due to Platelet Alloimmunization

Pathways related to Thrombocytopenia Due to Platelet Alloimmunization according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 GP9 ITGA2 ITGA2B MPL SELP THPO
2 12.29 ITGA2 ITGA2B MYH9
3
Show member pathways
11.79 GP9 ITGA2 ITGA2B
4 11.63 GP9 ITGA2 ITGA2B
5 11.52 ITGA2 ITGA2B MPL THPO
6 11.38 ITGA2 ITGA2B THPO
7 11.34 CD40LG SELP
8 11.28 ITGA2 ITGA2B
9
Show member pathways
11.25 GP9 ITGA2B MPL THPO
10 11.21 GP9 ITGA2 ITGA2B
11 11.18 CD40LG SELP
12 11.16 GP9 ITGA2B
13 11.04 ITGA2 ITGA2B
14 10.91 GP9 ITGA2 ITGA2B THPO
15 10.52 GP9 ITGA2

GO Terms for Thrombocytopenia Due to Platelet Alloimmunization

Cellular components related to Thrombocytopenia Due to Platelet Alloimmunization according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.91 CD40LG GP9 ITGA2 ITGA2B MPL MYH9
2 integral component of plasma membrane GO:0005887 9.72 CD40LG GP9 ITGA2B MPL SELP
3 focal adhesion GO:0005925 9.58 ITGA2 ITGA2B MYH9
4 cell surface GO:0009986 9.56 CD40LG ITGA2 ITGA2B MPL
5 external side of plasma membrane GO:0009897 9.26 CD40LG ITGA2 ITGA2B SELP
6 platelet alpha granule membrane GO:0031092 9.16 ITGA2B SELP
7 integrin complex GO:0008305 8.8 ITGA2 ITGA2B MYH9

Biological processes related to Thrombocytopenia Due to Platelet Alloimmunization according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.58 ITGA2 MPL THPO
2 cell adhesion GO:0007155 9.55 GP9 ITGA2 ITGA2B MYH9 SELP
3 integrin-mediated signaling pathway GO:0007229 9.43 ITGA2 ITGA2B MYH9
4 platelet aggregation GO:0070527 9.37 ITGA2B MYH9
5 leukocyte cell-cell adhesion GO:0007159 9.32 CD40LG SELP
6 thrombopoietin-mediated signaling pathway GO:0038163 8.96 MPL THPO
7 positive regulation of leukocyte migration GO:0002687 8.8 ITGA2 ITGA2B SELP

Sources for Thrombocytopenia Due to Platelet Alloimmunization

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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