Aliases & Classifications for Thrombocytosis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH
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Thrombocytosis, Aliases & Descriptions:

Name: Thrombocytosis 9 11 43 60
Platelet Count Above Reference Range 9
 
Thrombocythaemia 9
Thrombocythemia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


External Ids:

Disease Ontology9 DOID:2228
NCIt38 C35530
MeSH33 D013922

Summaries for Thrombocytosis

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Disease Ontology:9 A myeloma and blood platelet disease that is characterized by the presence of high platelet counts in the blood.

MalaCards based summary: Thrombocytosis, also known as platelet count above reference range, is related to myelofibrosis and refractory anemia. An important gene associated with Thrombocytosis is THPO (thrombopoietin), and among its related pathways are Development EPO induced Jak STAT pathway and Paxillin-dependent events mediated by a4b1. The drugs chlorambucil and uracil mustard and the compounds megapoietin and pp 100 have been mentioned in the context of this disorder. Affiliated tissues include myeloid, lung and bone, and related mouse phenotypes are cellular and immune system.

Wikipedia:63 Thrombocytosis (or thrombocythemia) is the presence of high platelet counts in the blood, and can be... more...

Related Diseases for Thrombocytosis

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Diseases related to Thrombocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 254)
idRelated DiseaseScoreTop Affiliating Genes
1myelofibrosis31.0THPO, JAK2
2refractory anemia30.9THPO, MPL, EPOR, JAK2
3purpura30.9THPO
4essential thrombocythemia30.8THPO, MPL, CD177, JAK2
5thrombocythemia 130.8THPO
6myeloid leukemia30.7JAK2, MPL, THPO
7megakaryocytic leukemia30.6EPOR, THPO
8splenomegaly30.4THPO, MPL, JAK2
9polycythemia vera30.4THPO, CD177, MPL, EPOR, JAK2
10polycythemia30.4CD177, MPL, EPOR, THPO, JAK2
11pancytopenia30.3MPL, THPO
12deficiency anemia30.2IL6, THPO, JAK2, EPOR, MPL
13chronic myelomonocytic leukemia30.2MPL, JAK2
14myocardial infarction30.2GP1BA, SERPINF2, FGA
15lung cancer30.1THPO, EPOR, FGA
16chronic myeloproliferative disease30.1JAK2, MPL, THPO
17aplastic anemia30.0THPO, GP1BA, MPL
18hepatoblastoma30.0THPO, MPL, EPOR
19pulmonary embolism29.9FGA, SERPINF2
20thrombocytopenia29.9FGA, IL6, MPL, THPO, GP1BA
21myelodysplastic syndrome29.8MPL, GP1BA, THPO, CD177, JAK2, EPOR
22myeloma29.7JAK2, IL6, EPOR
23sickle cell disease29.7EPOR, FGA
24vascular disease29.7SERPINF2, IL6, JAK2
25thrombophilia29.7FGA, SERPINF2
26coronary artery disease29.6FGA, JAK2, EPOR
27ischemia29.6EPOR, FGA, JAK2
28systemic lupus erythematosus29.5MPL, FGA, IL6
29nephrotic syndrome29.3SERPINF2, FGA
30atherosclerosis29.2IL6, SERPINF2, FGA
31leukemia29.2EPOR, THPO, MPL, SERPINF2, IL6, CD177
32acute leukemia29.2THPO, JAK2, FGA, MPL, EPOR
33iron deficiency anemia10.4
34renal cell carcinoma10.4
35thrombocytopenia, congenital amegakaryocytic10.4THPO, MPL
36thrombocythemia 310.3
37thrombocytopenia due to platelet alloimmunization10.3THPO, MPL
38thrombocytopenic purpura, autoimmune10.3MPL, THPO
39severe congenital neutropenia10.3THPO, JAK2
40bone marrow cancer10.3MPL, JAK2
41hemorrhagic thrombocythemia10.3
42pneumonia10.3
43acquired polycythemia10.3EPOR, JAK2
44primary polycythemia10.3EPOR, JAK2
45blood platelet disease10.3THPO, GP1BA
46chronic lymphocytic leukemia10.2
47colorectal cancer10.2
48arthritis10.2
49coronary thrombosis10.2
50rheumatoid arthritis10.2

Graphical network of the top 20 diseases related to Thrombocytosis:



Diseases related to thrombocytosis

Symptoms for Thrombocytosis

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Drugs & Therapeutics for Thrombocytosis

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Drug clinical trials:

Search ClinicalTrials for Thrombocytosis

Search NIH Clinical Center for Thrombocytosis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Thrombocytosis

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Anatomical Context for Thrombocytosis

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MalaCards organs/tissues related to Thrombocytosis:

31
Myeloid, Lung, Bone, Bone marrow, Liver, Heart, Breast, Neutrophil, Whole blood, Spleen, Thyroid, Skin, Endothelial, Lymph node, Colon, Ovary, Placenta, Testes, Tongue

Animal Models for Thrombocytosis or affiliated genes

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MGI Mouse Phenotypes related to Thrombocytosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.2IL6, JAK2, EPOR, MPL, GP1BA
2MP:00053877.3THPO, MPL, EPOR, JAK2, IL6, FGA
3MP:00053977.1FGA, THPO, GP1BA, MPL, EPOR, JAK2
4MP:00053766.7GP1BA, MPL, SERPINF2, EPOR, JAK2, IL6

Publications for Thrombocytosis

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Articles related to Thrombocytosis:

(show top 50)    (show all 608)
idTitleAuthorsYear
1
Paraneoplastic thrombocytosis independently predicts poor prognosis in patients with locally advanced pancreatic cancer. (25608822)
2015
2
Relation of Preoperative Thrombocytosis between Tumor Stage and Grade in Patients with Endometrial Cancer. (25610319)
2014
3
Reactive thrombocytosis leading to acute myocardial infarction. (24772734)
2013
4
Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer. (23080345)
2013
5
Impressive thrombocytosis evolving in a patient with a BCR-ABL positive CML in major molecular response during dasatinib treatment unmasks an additional JAK2V617F. (24007855)
2013
6
Plateletpheresis for postsplenectomy rebound thrombocytosis in a patient with chronic immune thrombocytopenic purpura on romiplostim. (23450778)
2013
7
The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer. (24285160)
2013
8
EXEL-8232, a small-molecule JAK2 inhibitor, effectively treats thrombocytosis and extramedullary hematopoiesis in a murine model of myeloproliferative neoplasm induced by MPLW515L. (22005786)
2012
9
Chronic myeloid leukemia with extreme thrombocytosis. (22479272)
2012
10
Absence of JAK2V617F mutation in patients with beta-thalassemia major and thrombocytosis due to splenectomy. (22203487)
2012
11
Impact of pretreatment thrombocytosis on blood-borne metastasis and prognosis of gastric cancer. (22592098)
2012
12
Teaching NeuroImages: disappearing intraluminal thrombus of the carotid artery in reactive thrombocytosis. (21502592)
2011
13
Thrombocytosis in children. (22075805)
2011
14
The impact of pretreatment thrombocytosis and persistent thrombocytosis after adjuvant chemotherapy in patients with advanced epithelial ovarian cancer. (21531448)
2011
15
Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis. (19903679)
2010
16
Cholestatic hepatitis and thrombocytosis in a secondary syphilis patient. (21060758)
2010
17
The role of the Platelet Function Analyzer (PFA)-100 and platelet aggregometry in the differentiation of essential thrombocythemia from reactive thrombocytosis. (19664802)
2010
18
A case of acute promyelocytic leukemia showing transient thrombocytosis caused by increased interleukin-6 and thrombopoietin after treatment with all-trans retinoic acid and chemotherapy. (19461187)
2009
19
The role of thrombocytosis in prognostic evaluation of epithelial ovarian tumors. (18470520)
2009
20
Isolated thrombocytosis as first sign of chronic myeloid leukemia with e6a2 BCR/ABL fusion transcript, JAK2 negativity and complete response to imatinib. (17688946)
2008
21
Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythemia. (18587010)
2008
22
Philadelphia chromosome-positive chronic myeloid leukemia with p190(BCR-ABL) rearrangement, overexpression of the EVI1 gene, and extreme thrombocytosis: a case report. (18262061)
2008
23
Aortic thrombus due to essential thrombocytosis: strategies for medical and surgical management. (18513483)
2008
24
Pulmonary hypertension in patients with essential thrombocythemia and reactive thrombocytosis. (17852711)
2007
25
Thrombocytosis induced in mice after subacute and subchronic V2O5 inhalation. (16716040)
2006
26
Extreme thrombocytosis: what are the etiologies? (16444439)
2006
27
Patterns of thrombocytosis and thrombocytopenia in hospitalized neonates. (15578031)
2005
28
Primary and secondary thrombocytosis in childhood. (15813844)
2005
29
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. (16293924)
2005
30
The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis. (13679323)
2003
31
Essential thrombocytosis causing a massive myocardial infarction. (12826291)
2003
32
Philadelphia chromosome and/or bcr-abl mRNA-positive primary thrombocytosis: morphometric evidence for the transition from essential thrombocythaemia to chronic myeloid leukaemia type of myeloproliferation. (12493025)
2003
33
Reactive thrombocytosis alone does not affect the patency of microvascular anastomosis in the splenectomy rat. (12172143)
2002
34
Bloodstream thrombopoietin in rheumatoid arthritis with thrombocytosis. (12447626)
2002
35
Thrombocytosis in children with iron deficiency anemia: series of 42 children. (12368707)
2002
36
Thrombocytosis is associated with a significant increase in the cancer specific death rate after radical nephrectomy. (12352397)
2002
37
Pseudohyperkalemia occurring in a patient with chronic renal failure and polycythemia vera without severe leukocytosis or thrombocytosis. (12508968)
2002
38
Familial thrombocytosis as a recessive, possibly X-linked trait in an Arab family. (11260062)
2001
39
Extreme self-limited thrombocytosis in a young patient. (11669311)
2001
40
Preoperative thrombocytosis is an independent prognostic factor in stage III and IV endometrial cancer. (11268488)
2000
41
Rapid reduction of platelet numbers in thrombocytosis. (11111819)
2000
42
Leucocytosis, thrombocytosis, and plasma osmolality during rest and exercise: an hypothesis. (10424721)
1999
43
The observation of reactive thrombocytosis in New Zealand white rabbits in response to experimental Pasteurella multocida infection. (10389591)
1999
44
Prolonged extreme thrombocytosis associated with neurofibromatosis type 1. (9042140)
1997
45
Elevated plasma thrombopoietic activity in patients with metastatic cancer-related thrombocytosis. (7539977)
1995
46
Establishment and characterization of a new human mesothelioma cell line (T-85) from malignant peritoneal mesothelioma with remarkable thrombocytosis. (8581142)
1995
47
High IL-6 levels in ascitic fluid correlate with reactive thrombocytosis in patients with epithelial ovarian cancer. (8485049)
1993
48
Serum interleukin-6 levels in patients with thrombocytosis. (1490150)
1992
49
Thrombocytosis and hyposplenism in an infant with fetal hydantoin syndrome. (1550265)
1992
50
Interleukin-1 beta (IL-1 beta) induces thrombocytosis in mice: possible implication of IL-6. (2265245)
1990

Variations for Thrombocytosis

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Expression for genes affiliated with Thrombocytosis

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Search GEO for disease gene expression data for Thrombocytosis.

Pathways for genes affiliated with Thrombocytosis

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Pathways related to Thrombocytosis according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
EPO Receptor Signaling36
EPO signaling pathway36
9.6EPOR, JAK2
2
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b736
a4b1 and a4b7 Integrin signaling36
9.6EPOR, JAK2
3
Show member pathways
IL27-mediated signaling events36
9.5IL6, JAK2
49.5IL6, JAK2
5
Show member pathways
9.5IL6, JAK2
69.5JAK2, IL6
7
Show member pathways
9.5JAK2, IL6
8
Show member pathways
9.5IL6, JAK2
99.4IL6, GP1BA
10
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.4JAK2, MPL, THPO
11
Show member pathways
9.2THPO, JAK2, IL6
12
Show member pathways
9.2EPOR, IL6, THPO
13
Show member pathways
9.2THPO, EPOR, IL6
149.1EPOR, JAK2, IL6
15
Show member pathways
9.1IL6, JAK2, EPOR
16
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.0FGA, SERPINF2
17
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.9THPO, MPL, JAK2, IL6
18
Show member pathways
Development EDNRB signaling58
Development ACM2 and ACM4 activation of ERK58
Cell adhesion Integrin inside out signaling58
Development G Proteins mediated regulation MARK ERK signaling58
Signal transduction IP3 signaling58
Development Angiotensin signaling via PYK258
Development EPO induced MAPK pathway58
8.8FGA, JAK2, EPOR
19
Show member pathways
8.8IL6, JAK2, EPOR, THPO
20
Show member pathways
8.8IL6, JAK2, EPOR, THPO
21
Show member pathways
8.8THPO, EPOR, JAK2, IL6
22
Show member pathways
8.7MPL, EPOR, JAK2, IL6
23
Show member pathways
Type III interferon signaling36
8.7MPL, EPOR, JAK2, IL6
248.7IL6, EPOR, GP1BA, THPO
25
Show member pathways
8.5GP1BA, SERPINF2, FGA
26
Show member pathways
8.5THPO, GP1BA, MPL, FGA
27
Show member pathways
8.4THPO, MPL, EPOR, JAK2, IL6
28
Show member pathways
7.1FGA, CD177, JAK2, SERPINF2, MPL, GP1BA

Compounds for genes affiliated with Thrombocytosis

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Compounds related to Thrombocytosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1megapoietin4310.2THPO, MPL
2pp 1004310.0EPOR, JAK2
3pixy321439.9IL6, THPO
4filgrastim43 1210.9IL6, THPO
5anagrelide43 1210.8JAK2, MPL, THPO
6phorbol 12,13-dibutyrate439.8JAK2, THPO
7polyethylene439.7FGA, THPO
8methylcellulose439.6IL6, EPOR, THPO
9ristocetin439.6SERPINF2, GP1BA
10gm-csf43 2810.5IL6, THPO
11fibrinopeptide a439.4SERPINF2, FGA
12agar439.4THPO, MPL, EPOR, JAK2
13sb 20358043 5910.3THPO, JAK2, IL6
14desmopressin43 59 28 1212.3SERPINF2, GP1BA
156-ketoprostaglandin f1alpha439.3SERPINF2, FGA
16asparagine439.2EPOR, SERPINF2, GP1BA
17ptca439.2FGA, SERPINF2
18cuprophan439.2FGA, SERPINF2
19latex439.2THPO, GP1BA, FGA
20ly294002439.2THPO, EPOR, JAK2, IL6
21actinomycin d439.1IL6, JAK2, EPOR, THPO
22lysine439.1THPO, MPL, SERPINF2, JAK2
23prostacyclin439.1THPO, GP1BA, FGA
24indomethacin43 28 59 1212.1THPO, GP1BA, JAK2, IL6
25oligonucleotide439.0THPO, GP1BA, EPOR, JAK2
26nitric oxide43 24 1211.0THPO, EPOR, JAK2, IL6
27gp 130438.9THPO, MPL, EPOR, JAK2, IL6
28phosphatidylinositol438.8THPO, GP1BA, MPL, EPOR, JAK2
29thromboxane43 249.8THPO, MPL, SERPINF2, FGA
30phenylalanine438.7GP1BA, EPOR, JAK2, FGA
31oxygen43 249.7THPO, SERPINF2, EPOR, JAK2
32hirudin438.6THPO, GP1BA, SERPINF2, FGA
33lactate438.6THPO, GP1BA, IL6, FGA
34glucose438.6THPO, GP1BA, EPOR, JAK2, IL6
35endotoxin438.5FGA, IL6, JAK2, SERPINF2
36heparin43 28 24 1211.5THPO, GP1BA, SERPINF2, FGA
37aspirin43 49 28 2411.5FGA, JAK2, MPL, GP1BA, THPO
38estrogen438.5THPO, EPOR, JAK2, IL6
39aprotinin43 129.4GP1BA, SERPINF2, IL6, FGA
40cholesterol43 28 24 1211.4FGA, IL6, JAK2, SERPINF2
41thymidine43 249.4THPO, EPOR, JAK2, IL6, FGA
42vegf438.2THPO, MPL, SERPINF2, EPOR, JAK2, IL6
43fibrinogen438.1THPO, GP1BA, SERPINF2, IL6, FGA
44lipid438.0SERPINF2, EPOR, JAK2, IL6, FGA
45adp43 28 249.9THPO, GP1BA, MPL, SERPINF2, JAK2, FGA
46alanine437.7THPO, GP1BA, MPL, SERPINF2, EPOR, JAK2
47epinephrine43 24 129.7FGA, IL6, JAK2, SERPINF2, GP1BA, THPO
48serine437.7GP1BA, MPL, SERPINF2, EPOR, JAK2, FGA
49calcium43 49 24 1210.7THPO, GP1BA, SERPINF2, EPOR, JAK2, FGA
50tyrosine437.1THPO, GP1BA, MPL, EPOR, JAK2, IL6

GO Terms for genes affiliated with Thrombocytosis

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Cellular components related to Thrombocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.0FGA, SERPINF2
2fibrinogen complexGO:00055778.9FGA, SERPINF2
3extracellular spaceGO:00056157.9FGA, IL6, SERPINF2, THPO

Biological processes related to Thrombocytosis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein import into nucleus, translocationGO:00331609.8IL6, JAK2
2positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.8JAK2, IL6
3positive regulation of nitric oxide biosynthetic processGO:00454299.7IL6, JAK2
4response to antibioticGO:00466779.7JAK2, IL6
5positive regulation of cell differentiationGO:00455979.6JAK2, SERPINF2
6fibrinolysisGO:00427309.6SERPINF2, GP1BA
7acute-phase responseGO:00069539.4IL6, SERPINF2
8positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.4IL6, JAK2
9positive regulation of smooth muscle cell proliferationGO:00486619.4SERPINF2, IL6
10positive regulation of protein kinase B signalingGO:00518979.3IL6, THPO
11positive regulation of ERK1 and ERK2 cascadeGO:00703749.3THPO, SERPINF2, IL6
12response to calcium ionGO:00515929.1FGA, IL6
13platelet degranulationGO:00025769.0FGA, SERPINF2
14platelet activationGO:00301687.6THPO, GP1BA, MPL, SERPINF2, IL6, FGA
15blood coagulationGO:00075967.4FGA, THPO, GP1BA, MPL, SERPINF2, JAK2

Products for genes affiliated with Thrombocytosis

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Sources for Thrombocytosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet