MCID: THR004
MIFTS: 61

Thrombocytosis malady

Blood category

Summaries for Thrombocytosis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A myeloma and blood platelet disorder that is characterized by the presence of high platelet counts in the blood.

MalaCards: Thrombocytosis, also known as platelet count above reference range, is related to refractory anemia and iron deficiency anemia. An important gene associated with Thrombocytosis is THPO (thrombopoietin), and among its related pathways are Signaling events mediated by Stem cell factor receptor (c-Kit) and Development EPO-induced Jak-STAT pathway. The drugs chlorambucil and uracil mustard and the compounds pge2 and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are integument and liver/biliary system.

Wikipedia:64 Thrombocytosis (or thrombocythemia) is the presence of high platelet counts in the blood, and can be... more...

Aliases & Classifications for Thrombocytosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

thrombocytosis 8 10 45 61
platelet count above reference range 8
thrombocythaemia 8
thrombocythemia 8


External Ids:

Disease Ontology8 DOID:2228
MeSH35 D013922
NCIt40 C35530

Related Diseases for Thrombocytosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Thrombocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 306)
idRelated DiseaseScoreTop Affiliating Genes
1refractory anemia30.8THPO, IL11, IL3, JAK2, MPL, EPO
2iron deficiency anemia30.6EPO, THPO
3polycythemia vera30.6PF4, IL3, THPO, SELP, EPOR, EPO
4deficiency anemia30.6CRP, MPL, LIF, NFE2, EPO, EPOR
5acute leukemia30.5JAK2, MPL, EPO, EPOR, FGA, IL3
6thrombocytopenia30.5MPL, NFE2, EPO, PF4, FGA, IL3
7thromboembolism30.4PF4, FGA, SELP, SERPINF2
8myeloproliferative disorder30.4IL3, IL11, THPO, SELP, PF4, PPBP
9arthritis30.3IL6, LIF, CRP
10chronic myeloid leukemia30.3CEBPB, SELP, THPO, IL11, PPBP, JAK2
11hypercalcemia30.3LIF
12acute myocardial infarction30.3PPBP, CRP, PF4, FGA, SELP, SERPINF2
13colorectal cancer30.2PF4, SELP, CEBPB
14leukemoid reaction30.2IL3
15erythrocytosis30.2JAK2, MPL, CD177, EPO, EPOR, IL3
16megakaryocytic leukemia30.1IL11, IL3, PF4, EPOR, THPO
17primary polycythemia30.1JAK2, EPO, EPOR
18hemorrhagic thrombocythemia30.1CD177
19portal vein thrombosis30.0THPO
20bronchiolitis30.0IL11
21hepatitis c30.0THPO
22thalassemia30.0EPO
23kawasaki disease30.0CRP
24antiphospholipid syndrome30.0SELP, PF4
25acquired thrombocytopenia30.0IL11, THPO
26splenomegaly30.0JAK2, MPL, EPO, THPO
27tuberculosis30.0CEBPB, IL11, PF4, CRP
28myelodysplastic syndromes30.0JAK2, MPL, CD177, EPO, EPOR, IL3
29vasculitis29.9PPBP, CRP, FGA, SELP
30hyperhomocysteinemia29.8CRP, SELP
31stroke, ischemic29.8PPBP, PF4, FGA, SELP
32aplastic anemia29.8MPL, EPO, IL3, IL11, GP1BA, THPO
33atherosclerosis29.8PPBP, CRP, LIF, PF4, FGA, IL6
34poems syndrome29.7IL6
35autoimmune thrombocytopenic purpura29.7MPL, THPO
36pancytopenia29.7THPO, IL3, EPO, MPL
37thrombophilia29.7PPBP, PF4, FGA, SELP, SERPINF2
38venous thrombosis29.7JAK2, PF4, FGA, SELP, SERPINF2
39pheochromocytoma29.7EPOR, LIF
40pulmonary disease, chronic obstructive29.7IL6, CRP
41sickle cell disease29.7EPO, EPOR, PF4, FGA, SELP, PPBP
42vascular disease29.7PPBP, CRP, FGA, GP1BA, SELP
43coronary artery disease,29.7PPBP, CRP, PF4, FGA, IL6, GP1BA
44down syndrome29.7JAK2
45systemic lupus erythematosus29.7CRP, MPL, FGA, IL6
46essential thrombocythemia10.5
47t-cell leukemia10.4
48thrombocythemia 210.4
49n syndrome10.3
50ovarian epithelial cancer10.3

Graphical network of the top 20 diseases related to Thrombocytosis:



Diseases related to thrombocytosis

Clinical Features for Thrombocytosis

Drugs & Therapeutics for Thrombocytosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Thrombocytosis

Drug clinical trials:

Search ClinicalTrials for Thrombocytosis

Search NIH Clinical Center for Thrombocytosis

Search CenterWatch for Thrombocytosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Thrombocytosis

Anatomical Context for Thrombocytosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Thrombocytosis:

33
Bone marrow, Whole blood, Lymph node, Spleen, Heart, Colon, Liver, Lung, Thyroid, Breast, Skin, Ovary, Placenta, Myeloid, T cells, Endothelial, Tongue, Fetal liver, Fetal lung, Fetal thyroid

Animal Models for Thrombocytosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Thrombocytosis

Sources:
51PubMed
See all sources

Articles related to Thrombocytosis:

(show top 50)    (show all 573)
idTitleAuthorsYear
1
Germline JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors. (24398328)
2014
2
The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer. (24285160)
2013
3
Evaluating the prognostic significance of preoperative thrombocytosis in epithelial ovarian cancer. (23747328)
2013
4
Iron deficiency generates secondary thrombocytosis and platelet activation in inflammatory bowel disease : the randomized, controlled ThromboVIT trial. (23962897)
2013
5
Thrombocytosis is associated with Mycobacterium tuberculosis infection and positive acid-fast stains in granulomas. (23596109)
2013
6
Prevalence of thrombocytosis in critically ill patients and its association with symptomatic acute pulmonary embolism. A multicentre registry study. (23238075)
2013
7
Heparin resistance and excessive thrombocytosis. (24149508)
2013
8
Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. (23584088)
2013
9
Refractory anemia with ring sideroblasts associated with marked thrombocytosis complicated by massive splenomegaly treated with lenalidomide resulting in resolution of splenomegaly but severe and prolonged pancytopenia. (23653870)
2013
10
Absence of JAK2V617F mutation in patients with beta-thalassemia major and thrombocytosis due to splenectomy. (22203487)
2012
11
Does thrombocyte size give us an idea about thrombocytosis etiology? (22997499)
2012
12
Impact of preoperative thrombocytosis on the survival of patients with primary colorectal cancer. (22045447)
2012
13
Fever of unknown origin, anemia and thrombocytosis as early symptoms and signs of a late-onset polymialgia rheumatica: a diagnostic challenge. (22588450)
2012
14
Helicobacter pylori-induced thrombocytosis clinically indistinguishable from essential thrombocythemia. (22204454)
2012
15
Prognostic value of TP/PD-ECGF and thrombocytosis in gastric carcinoma. (22595739)
2012
16
Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: analysis of molecular genetics and clinical phenotypes. (21712540)
2011
17
Diagnostic and prognostic value of thrombocytosis in admitted medical patients. (21681080)
2011
18
Reactive thrombocytosis in children with viral respiratory tract infections. (21909061)
2011
19
Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis. (19903679)
2010
20
Cholestatic hepatitis and thrombocytosis in a secondary syphilis patient. (21060758)
2010
21
CHILD syndrome with thrombocytosis and congenital dislocation of hip: A case report from India. (20804683)
2010
22
Mitroaortic valve replacement after aortic transapical approach failure in a patient with essential thrombocytosis. (20542979)
2010
23
Thrombocytosis in patients with severe community-acquired pneumonia. (21051412)
2010
24
Thrombocytosis in EPO-treated dialysis patients may be mediated by EPO rather than iron deficiency. (19303685)
2009
25
PEComa (clear cell "sugar" tumor) of the lung: a benign tumor that presented with thrombocytosis. (19932282)
2009
26
Evaluation of association between precolectomy thrombocytosis and the occurrence of inflammatory pouch disorders. (19966641)
2009
27
Is refractory anaemia with ring sideroblasts and thrombocytosis (RARS-T) a necessary or useful diagnostic category? (19120370)
2009
28
Thrombocytosis and thrombosis. (18024652)
2007
29
Rebound thrombocytosis causing MI following dengue fever? (19098345)
2007
30
Diabetes insipidus and thrombocytosis as the presenting symptoms of acute myeloblastic leukemia with monosomy 7. (16432854)
2006
31
Thrombocytosis and toxocariasis: report of two pediatric cases. (15468308)
2005
32
Neutrophil hypersegmentation and thrombocytosis in children with iron deficiency anemia. (16250310)
2005
33
Essential thrombocytosis manifested as myocardial infarction and congestive heart failure: two case reports. (16385927)
2005
34
Reactive thrombocytosis: an early manifestation of Takayasu arteritis. (16357775)
2005
35
A case of familial thrombocytosis: possible role of altered thrombopoietin production. (15282677)
2004
36
Essential thrombocytosis: diagnostic and treatment dilemmas. (14750750)
2003
37
Aortic mural thrombus embolization: an unusual presentation of essential thrombocytosis. (11957005)
2002
38
Extreme thrombocytosis as a sign of coeliac disease in the elderly: case report. (12172415)
2002
39
Huge skin tumor diffuse large cell lymphoma associated with essential thrombocytosis. (11518141)
2001
40
Use of a platelet filter test in patients with thrombocytosis. (10938880)
2000
41
Leucocytosis, thrombocytosis, and plasma osmolality during rest and exercise: an hypothesis. (10424721)
1999
42
Leg ulceration with associated thrombocytosis: healing of ulceration associated with treatment of the raised platelet count. (10215806)
1999
43
5-year incidence of thrombocytosis and the effect on heparin dose response and heparin requirements. (10915475)
1999
44
Vestibular disorders in primary thrombocytosis. (10604160)
1999
45
Humorally mediated thrombocytosis in major lower extremity trauma. (9600428)
1998
46
Blood thrombopoietin levels in clonal thrombocytosis and reactive thrombocytosis. (9626028)
1998
47
Elevated plasma thrombopoietic activity in patients with metastatic cancer-related thrombocytosis. (7539977)
1995
48
C-reactive protein in differential diagnosis of primary thrombocytosis]. (7739278)
1995
49
IgG lambda-type multiple myeloma associated with myelofibrosis accompanied by thrombocytosis]. (1942535)
1991
50
Macrocytic anemia, thrombocytosis and nonlobulated megakaryocytes: the 5q-syndrome, a distinct entity. (453227)
1979

Genetic Variations for Thrombocytosis

Expression for genes affiliated with Thrombocytosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Thrombocytosis

Search GEO for disease gene expression data for Thrombocytosis.

Pathways for genes affiliated with Thrombocytosis

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 53R&D Systems, 52QIAGEN, 4Cell Signaling Technology, 30KEGG
See all sources

Pathways related to Thrombocytosis according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3JAK2, EPO, EPOR
2
Development EPO-induced Jak-STAT pathway
Hide members
10.3EPOR, EPO, JAK2
310.3EPOR, EPO, JAK2
4
Hide members
10.3SERPINF2, GP1BA, FGA
5
Hide members
10.3PPBP, MPL, THPO
610.3IL6, GP1BA, SELP
710.3CEBPB, IL6, JAK2
8
Mucin expression in CF via IL-6, IL-17 signaling pathways
Hide members
10.3CEBPB, IL6, JAK2
9
Hide members
10.3JAK2, MPL, IL6, THPO
1010.3JAK2, SELP, CEBPB
11
Hide members
10.3THPO, GP1BA, FGA, MPL
12
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
10.3JAK2, CRP, MPL, THPO
13
Hide members
10.3JAK2, EPO, EPOR, FGA
14
Hide members
10.3PPBP, IL3, IL6, THPO
1510.3JAK2, CRP, IL6, CEBPB
16
Hide members
10.3FGA, GP1BA, THPO, SELP, SERPINF2
1710.2JAK2, EPO, EPOR, IL3, IL6
18
Hide members
10.2PPBP, JAK2, IL3, IL6, THPO
19
Hide members
10.2JAK2, LIF, EPOR, IL11, IL6
20
Hide members
10.2THPO, IL6, IL3, EPOR, PPBP
21
Hide members
10.2PPBP, EPOR, IL3, IL6, THPO
22
Hide members
10.2PPBP, PF4, FGA, SELP, SERPINF2
23
Hide members
10.2PPBP, JAK2, EPOR, IL3, IL6, THPO
24
Hide members
10.2PPBP, LIF, EPOR, IL3, IL6, THPO
25
Hide members
10.2PPBP, CRP, EPOR, IL3, IL6, THPO
26
Hide members
10.2PPBP, JAK2, MPL, NFE2, CD177, PF4
2710.1EPO, EPOR, IL3, IL11, IL6, GP1BA
2810.1IL6, JAK2, MPL, LIF, EPO, EPOR
29
Hide members
10.1PPBP, JAK2, MPL, LIF, EPOR, IL3
30
Hide members
10.0IL6, IL11, IL3, PF4, EPOR, LIF
31
Hide members
10.0PPBP, CEBPB, THPO, IL6, IL11, IL3
32
Hide members
9.9PPBP, JAK2, LIF, EPOR, PF4, IL3

Compounds for genes affiliated with Thrombocytosis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB
See all sources

Compounds related to Thrombocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
1pge24510.8PF4
2gm-csf45 2911.7THPO, IL11, LIF
3anagrelide45 1111.7JAK2, MPL, EPO, PF4, THPO
4il 114510.6LIF, EPO, IL3, IL11, IL6
5pixy3214510.6EPO, IL3, IL11, IL6, THPO
6filgrastim45 1111.6LIF, EPO, IL3, IL11, IL6, THPO
7endotoxin4510.6JAK2, LIF, FGA, IL11, CEBPB
8aprotinin45 1111.6PPBP, EPO, PF4, FGA, SELP, SERPINF2
9cuprophan4510.6LIF, EPO, PF4, FGA, SELP, SERPINF2
10ristocetin4510.6PPBP, EPO, GP1BA, SELP, SERPINF2
11methylcellulose4510.6LIF, EPO, EPOR, IL3, IL11, IL6
12hirudin4510.6PF4, FGA, GP1BA, THPO, SELP, SERPINF2
13polysulfone4510.5PPBP, CRP, EPO, PF4, FGA, SELP
14ptca4510.5PPBP, PF4, FGA, SELP, SERPINF2
15thromboxane45 2411.5PPBP, MPL, NFE2, PF4, FGA, THPO
16txb24510.5PPBP, LIF, PF4, FGA, IL11, SELP
17desmopressin45 60 29 1113.5PPBP, EPO, GP1BA, SELP, SERPINF2
18iohexol4510.5PPBP, PF4, FGA, SELP
19thromboxane a245 2411.5PPBP, LIF, PF4, FGA, THPO, SELP
20latex4510.5PPBP, CRP, LIF, PF4, FGA, GP1BA
21glucose4510.5PPBP, LIF, PF4, IL11, GP1BA, CEBPB
22rantes4510.5PPBP, LIF, PF4, IL3, IL11, IL6
23gp 1304510.4EPO, EPOR, IL3, IL11, IL6, THPO
24prostacyclin4510.4PPBP, CRP, PF4, FGA, IL3, GP1BA
25hydroxyurea45 50 1112.4PPBP, JAK2, EPO, PF4, IL3, THPO
2611-dehydrothromboxane b24510.4PPBP, PF4, FGA, SELP
27heparin45 29 11 2413.4PPBP, LIF, PF4, FGA, IL11, GP1BA
28epinephrine45 11 2412.4PPBP, JAK2, PF4, FGA, IL11, IL6
29aspirin45 50 29 2413.4PPBP, JAK2, CRP, MPL, PF4, FGA
30ly2940024510.4JAK2, CRP, EPO, EPOR, IL3, IL6
31agar4510.4JAK2, MPL, LIF, EPOR, PF4, IL3
32histamine45 29 2412.4PPBP, PF4, FGA, IL3, IL11, IL6
33actinomycin d4510.4JAK2, LIF, NFE2, EPOR, IL3, IL6
34indomethacin45 60 29 1113.4CEBPB, GP1BA, PF4
35thymidine45 2411.4EPO, LIF, JAK2, PPBP, EPOR, PF4
36lactate4510.3PPBP, CRP, LIF, EPO, PF4, FGA
37creatinine4510.3PPBP, CRP, LIF, EPO, PF4, FGA
38oxygen45 2411.3JAK2, EPO, EPOR, PF4, IL11, SERPINF2
39dexamethasone45 50 29 1113.3PPBP, LIF, IL3, IL6, CEBPB
40alanine4510.3EPOR, MPL, CRP, JAK2, PPBP, PF4
41fibrinogen4510.3FGA, IL11, IL6, GP1BA, THPO, SELP
42phosphatidylinositol4510.3PPBP, JAK2, MPL, LIF, EPO, EPOR
43vegf4510.3IL11, IL6, THPO, SELP, SERPINF2, PF4
44amifostine45 1111.3EPO, IL3, IL11, THPO
45cholesterol45 29 11 2413.2PPBP, JAK2, CRP, LIF, PF4, FGA
46cysteine4510.1PPBP, JAK2, MPL, LIF, EPOR, PF4
47tyrosine4510.1PPBP, JAK2, MPL, CEBPB, SELP, THPO
48tgf beta14510.1PPBP, LIF, PF4, IL11, IL6, THPO
49nitric oxide45 11 2412.0JAK2, LIF, EPOR, IL11, IL6, THPO
506-ketoprostaglandin f1alpha4510.0PPBP, PF4, FGA, SERPINF2

GO Terms for genes affiliated with Thrombocytosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Thrombocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:00557710.4SERPINF2, FGA
2platelet alpha granule lumenGO:03109310.0PPBP, PF4, FGA, SERPINF2
3extracellular spaceGO:0056159.9SERPINF2, PPBP, CRP, LIF, EPO, PF4
4extracellular regionGO:0055769.9EPOR, EPO, CRP, PPBP, PF4, FGA

Biological processes related to Thrombocytosis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.6IL3, EPO, JAK2
2negative regulation of hormone secretionGO:04688810.6LIF, IL11, IL6
3positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.6IL6, LIF, JAK2
4tyrosine phosphorylation of Stat3 proteinGO:04250310.6LIF, JAK2
5acute-phase responseGO:00695310.6CRP, IL6, SERPINF2, CEBPB
6positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5JAK2, LIF, IL3, IL11, IL6
7positive regulation of DNA replicationGO:04574010.5EPO, IL3, IL6
8platelet degranulationGO:00257610.5PPBP, PF4, FGA, SELP, SERPINF2
9response to lipopolysaccharideGO:03249610.5JAK2, EPO, IL6, SELP, CEBPB
10positive regulation of peptidyl-serine phosphorylationGO:03313810.5IL6, IL11, LIF
11negative regulation of lipid storageGO:01088810.4IL6, CRP
12positive regulation of MAPK cascadeGO:04341010.4LIF, IL11, IL6
13positive regulation of cell proliferationGO:00828410.4JAK2, LIF, EPO, IL3, IL11, IL6
14positive regulation of macrophage differentiationGO:04565110.4LIF, PF4
15platelet activationGO:03016810.3SERPINF2, PPBP, MPL, PF4, FGA, IL11
16positive regulation of protein import into nucleus, translocationGO:03316010.3IL6, JAK2
17blood coagulationGO:00759610.3PPBP, JAK2, MPL, NFE2, CD177, PF4
18inflammatory responseGO:00695410.3CEBPB, SELP, IL6, CRP
19agingGO:00756810.0CRP, EPO, IL6

Molecular functions related to Thrombocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.2THPO, IL6, IL11, IL3, LIF
2growth factor activityGO:0080839.9THPO, PPBP, LIF, IL3, IL11, IL6

Products for genes affiliated with Thrombocytosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thrombocytosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet