MCID: THR004
MIFTS: 63

Thrombocytosis malady

Blood diseases category

Summaries for Thrombocytosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A myeloma and blood platelet disorder that is characterized by the presence of high platelet counts in the blood.

MalaCards: Thrombocytosis, also known as platelet count above reference range, is related to leukemia and iron deficiency anemia. An important gene associated with Thrombocytosis is THPO (thrombopoietin), and among its related pathways are Signaling events mediated by Stem cell factor receptor (c-Kit) and Development EPO-induced Jak-STAT pathway. The drugs chlorambucil and uracil mustard and the compounds pge2 and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include myeloid, lung and bone marrow, and related mouse phenotypes are integument and liver/biliary system.

Wikipedia:63 Thrombocytosis (or thrombocythemia) is the presence of high platelet counts in the blood, and can be... more...

Aliases & Classifications for Thrombocytosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

thrombocytosis 8 10 44 60
platelet count above reference range 8
thrombocythaemia 8
thrombocythemia 8


External Ids:

Disease Ontology8 DOID:2228
MeSH34 D013922
NCIt39 C35530

Related Diseases for Thrombocytosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Thrombocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 306)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.7EPO, CD177, NFE2, LIF, MPL, JAK2
2iron deficiency anemia30.5EPO, THPO
3polycythemia30.5THPO, PPBP, JAK2, MPL, NFE2, CD177
4polycythemia vera30.5PF4, IL3, THPO, SELP, EPOR, EPO
5deficiency anemia30.5CRP, MPL, LIF, NFE2, EPO, EPOR
6ovarian cancer30.5JAK2, LIF, FGA, IL3, IL11
7acute leukemia30.5JAK2, MPL, EPO, EPOR, FGA, IL3
8thrombocytopenia30.5MPL, NFE2, EPO, PF4, FGA, IL3
9myocardial infarction30.5SERPINF2, SELP, GP1BA, IL11, FGA, PF4
10myelofibrosis30.4JAK2, EPO, THPO
11myeloid leukemia30.4JAK2, MPL, LIF, IL3, IL11, THPO
12pneumonia30.3CRP, FGA, IL11, IL6
13arthritis30.3IL6, LIF, CRP
14chronic myeloid leukemia30.3CEBPB, SELP, THPO, IL11, PPBP, JAK2
15hypercalcemia30.2LIF
16hemorrhagic thrombocythemia30.2CD177
17acute myocardial infarction30.2PPBP, CRP, PF4, FGA, SELP, SERPINF2
18rheumatoid arthritis30.2PPBP, JAK2, CRP, LIF, PF4, IL11
19sarcoma30.2THPO, JAK2
20megakaryocytic leukemia30.2IL11, IL3, PF4, EPOR, THPO
21colorectal cancer30.1PF4, SELP, CEBPB
22leukemoid reaction30.1IL3
23inflammatory bowel disease30.1SELP, IL6, IL11, CRP, JAK2
24purpura30.0THPO
25primary polycythemia30.0JAK2, EPO, EPOR
26pancreatitis30.0CRP, IL11, IL6, SELP
27hepatocellular carcinoma30.0IL6, EPOR, PPBP
28breast cancer30.0PPBP, JAK2, LIF, EPOR, IL11, GP1BA
29portal vein thrombosis29.9THPO
30bronchiolitis29.9IL11
31pancreatic cancer29.9CEBPB
32hypertension29.9CRP, PPBP
33kawasaki disease29.9CRP
34antiphospholipid syndrome29.9SELP, PF4
35acquired thrombocytopenia29.9IL11, THPO
36ischemia29.9JAK2, EPOR, PF4, FGA, SELP
37tuberculosis29.9CEBPB, IL11, PF4, CRP
38vasculitis29.9PPBP, CRP, FGA, SELP
39hyperhomocysteinemia29.7CRP, SELP
40skin disease29.7IL6
41stroke, ischemic29.7PPBP, PF4, FGA, SELP
42dilated cardiomyopathy29.7FGA
43aplastic anemia29.7MPL, EPO, IL3, IL11, GP1BA, THPO
44diabetes mellitus29.7CRP, PF4, FGA, IL6, GP1BA, SELP
45atherosclerosis29.7PPBP, CRP, LIF, PF4, FGA, IL6
46multiple myeloma29.7IL6
47glomerulonephritis29.7EPOR
48hepatitis c29.7THPO
49chronic myeloproliferative disease29.7JAK2, MPL, THPO
50nephrotic syndrome29.7SERPINF2, FGA, PPBP

Graphical network of the top 20 diseases related to Thrombocytosis:



Diseases related to thrombocytosis

Clinical Features for Thrombocytosis

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Drugs & Therapeutics for Thrombocytosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Thrombocytosis

Drug clinical trials:

Search ClinicalTrials for Thrombocytosis

Search NIH Clinical Center for Thrombocytosis

Search CenterWatch for Thrombocytosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Thrombocytosis

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Anatomical Context for Thrombocytosis

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32MalaCards
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MalaCards organs/tissues related to Thrombocytosis:

32
Myeloid, Lung, Bone marrow, Bone, Liver, Breast, Heart, Endothelial, Skin, Spleen, Whole blood, Thyroid, Colon, Testes, Lymph node, Tongue, Ovary, Placenta

Animal Models for Thrombocytosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thrombocytosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.3LIF, NFE2, FGA, IL6, CEBPB
2MP:000537010.2LIF, EPO, EPOR, FGA, IL6, SELP
3MP:000539010.2LIF, NFE2, FGA, IL6, CEBPB, JAK2
4MP:000538710.0JAK2, CRP, MPL, LIF, NFE2, EPOR
5MP:000538410.0JAK2, MPL, LIF, EPO, EPOR, IL3
6MP:000539710.0CEBPB, JAK2, MPL, LIF, NFE2, EPO
7MP:000537610.0EPOR, EPO, LIF, MPL, CRP, JAK2
8MP:00107689.8NFE2, LIF, MPL, JAK2, EPO, EPOR
9MP:00053859.8CRP, LIF, NFE2, EPO, EPOR, FGA

Publications for Thrombocytosis

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50PubMed
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Articles related to Thrombocytosis:

(show top 50)    (show all 573)
idTitleAuthorsYear
1
Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer. (23080345)
2013
2
The impact of thrombocytosis on clinicopathological prognostic factors and survival in patients with vulvar cancer. (24032263)
2013
3
A case of refractory anemia with ring sideroblasts and associated thrombocytosis. (23844433)
2013
4
High frequencies of SF3B1 and JAK2 mutations in refractory anemia with ring sideroblasts associated with marked thrombocytosis strengthen the assignment to the category of myelodysplastic/myeloproliferative neoplasms. (22929973)
2013
5
Impact of pretreatment thrombocytosis on blood-borne metastasis and prognosis of gastric cancer. (22592098)
2012
6
In vitro thrombotic tendency of reactive thrombocytosis in critically ill patients: a prospective case-control study. (22577913)
2012
7
Cyclic thrombocytopenia associated with marked rebound thrombocytosis and fluctuating levels of endogenous thrombopoietin and reticulated platelets: a case report. (22038676)
2012
8
A rare case of postpartum thrombocytosis. Differential diagnosis and management. (23017286)
2012
9
Thrombocytosis: diagnostic evaluation, thrombotic risk stratification, and risk-based management strategies. (22084665)
2011
10
Acute myocardial infarction in a patient with post-splenectomy thrombocytosis: a case report and review of literature. (20104461)
2010
11
A case of acute promyelocytic leukemia showing transient thrombocytosis caused by increased interleukin-6 and thrombopoietin after treatment with all-trans retinoic acid and chemotherapy. (19461187)
2009
12
The role of thrombocytosis in prognostic evaluation of epithelial ovarian tumors. (18470520)
2009
13
Granulocytosis and thrombocytosis in renal cell carcinoma: a pro-inflammatory cytokine response originating in the tumour. (19581670)
2009
14
Preoperative leukocytosis, anemia and thrombocytosis are associated with poor survival in non-small cell lung cancer. (19596947)
2009
15
Transient thrombocytosis with megathrombocytes in a case of acute myeloblastic leukemia. (19136802)
2009
16
Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a. (19497108)
2009
17
Prognostic interaction between thrombocytosis and JAK2 V617F mutation in the WHO subcategories of myelodysplastic/myeloproliferative disease-unclassifiable and refractory anemia with ringed sideroblasts and marked thrombocytosis. (18059483)
2008
18
Thrombocytosis associated with malignant ovarian lesions within a pediatric/adolescent population. (18794018)
2008
19
Marked thrombocytosis during treatment with ceftazidime for pulmonary infection. (17619167)
2008
20
The prognostic significance of thrombocytosis in uterine papillary serous carcinomas. (16934317)
2007
21
Thrombocytosis in systemic lupus erythematosus: a possible clue to autosplenectomy? (17552043)
2007
22
Neonatal thrombocytosis following G-CSF treatment. (17917868)
2007
23
Extreme thrombocytosis: what are the etiologies? (16444439)
2006
24
Ringed sideroblasts with thrombocytosis: an uncommon mixed myelodysplastic/myeloproliferative disease in older adults. (16787502)
2006
25
Megakaryopoiesis and thrombocytosis. (15481081)
2005
26
A retrospective analysis of myelodysplastic syndromes with thrombocytosis: reclassification of the cases by WHO proposals. (15725469)
2005
27
Reticular erythematous mucinosis (REM) with telangiectasias associated with essential thrombocytosis and lung carcinoma. (15908303)
2005
28
Thrombocytosis in gynecologic malignancies. (15274400)
2004
29
Thrombocytosis associated with poor prognosis in patients with esophageal carcinoma. (15110807)
2004
30
Prognostic significance of thrombocytosis in renal cell carcinoma patients. (15157203)
2004
31
Anagrelide for thrombocytosis in myeloproliferative disorders: a prospective study to assess efficacy and adverse event profile. (15476273)
2004
32
Essential thrombocytosis causing a massive myocardial infarction. (12826291)
2003
33
Classification and molecular biology of polycythemias (erythrocytoses) and thrombocytosis. (14560779)
2003
34
Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis. (12623846)
2003
35
Sideroblastic anaemia with reactive thrombocytosis versus myelodysplastic/myeloproliferative disease. (12688334)
2003
36
Spurious thrombocytosis associated with cryoglobulinaemia: a case report. (12161384)
2002
37
Thrombocytosis and thrombocythemia. (11792116)
2001
38
Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis. (11675343)
2001
39
Digital gangrene after radial artery catheterization in a patient with thrombocytosis. (10624974)
2000
40
Thrombocytosis--report of a case. (11273186)
2000
41
Elevated serum thrombopoietin and interleukin-6 concentrations in thrombocytosis associated with inflammatory bowel disease. (10454346)
1999
42
High-Dose Abciximab During Coronary Angioplasty in a Patient with Essential Thrombocytosis. (10762789)
1998
43
Mechanism of thrombocytosis in hepatoblastoma: a case report. (8940737)
1996
44
Increased secretion of interleukin-6 in malignant mesothelioma cells from a patient with marked thrombocytosis. (1394040)
1992
45
Elevated serum interleukin-6 levels in patients with reactive thrombocytosis. (1958487)
1991
46
Chronic eosinophilic pneumonia associated with thrombocytosis and pleural effusion. (2322915)
1990
47
Thrombocytosis associated with a myeloproliferative disorder in a dog. (2722642)
1989
48
Fatal cerebrovascular thrombosis in a young woman: an unusual complication associated with hypochromic anemia and thrombocytosis following surgery. (3266301)
1988
49
Alcoholic hepatitis with leukemoid reaction and thrombocytosis. (1165757)
1975
50
Iron deficiency anemia, papilledema, thrombocytosis, and transient hemiparesis. (5017685)
1972

Genetic Variations for Thrombocytosis

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Expression for genes affiliated with Thrombocytosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thrombocytosis

Search GEO for disease gene expression data for Thrombocytosis.

Pathways for genes affiliated with Thrombocytosis

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 52R&D Systems, 51QIAGEN, 4Cell Signaling Technology, 29KEGG
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Pathways related to Thrombocytosis according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3JAK2, EPO, EPOR
2
Development EPO-induced Jak-STAT pathway
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10.3EPOR, EPO, JAK2
310.3EPOR, EPO, JAK2
4
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10.3SERPINF2, GP1BA, FGA
5
Hide members
10.3PPBP, MPL, THPO
610.3IL6, GP1BA, SELP
710.3CEBPB, IL6, JAK2
8
Mucin expression in CF via IL-6, IL-17 signaling pathways
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10.3CEBPB, IL6, JAK2
9
Hide members
10.3JAK2, MPL, IL6, THPO
1010.3JAK2, SELP, CEBPB
11
Hide members
10.3THPO, GP1BA, FGA, MPL
12
Development Thrombopoetin signaling via JAK-STAT pathway
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10.3JAK2, CRP, MPL, THPO
13
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10.3JAK2, EPO, EPOR, FGA
14
Hide members
10.3PPBP, IL3, IL6, THPO
1510.3JAK2, CRP, IL6, CEBPB
16
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10.3FGA, GP1BA, THPO, SELP, SERPINF2
1710.2JAK2, EPO, EPOR, IL3, IL6
18
Hide members
10.2PPBP, JAK2, IL3, IL6, THPO
19
Hide members
10.2JAK2, LIF, EPOR, IL11, IL6
20
Hide members
10.2THPO, IL6, IL3, EPOR, PPBP
21
Hide members
10.2PPBP, EPOR, IL3, IL6, THPO
22
Hide members
10.2PPBP, PF4, FGA, SELP, SERPINF2
23
Hide members
10.2PPBP, JAK2, EPOR, IL3, IL6, THPO
24
Hide members
10.2PPBP, LIF, EPOR, IL3, IL6, THPO
25
Hide members
10.2PPBP, CRP, EPOR, IL3, IL6, THPO
26
Hide members
10.2PPBP, JAK2, MPL, NFE2, CD177, PF4
2710.1EPO, EPOR, IL3, IL11, IL6, GP1BA
2810.1IL6, JAK2, MPL, LIF, EPO, EPOR
29
Hide members
10.1PPBP, JAK2, MPL, LIF, EPOR, IL3
30
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10.0IL6, IL11, IL3, PF4, EPOR, LIF
31
Hide members
10.0PPBP, CEBPB, THPO, IL6, IL11, IL3
32
Hide members
9.9PPBP, JAK2, LIF, EPOR, PF4, IL3

Compounds for genes affiliated with Thrombocytosis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Thrombocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
1pge24410.8PF4
2gm-csf44 2811.7THPO, LIF, IL11
3anagrelide44 1111.7JAK2, EPO, MPL, THPO, PF4
4il 114410.6LIF, EPO, IL6, IL11, IL3
5pixy3214410.6IL3, THPO, IL6, IL11, EPO
6filgrastim44 1111.6IL6, THPO, EPO, LIF, IL11, IL3
7endotoxin4410.6CEBPB, LIF, JAK2, FGA, IL11
8aprotinin44 1111.6SERPINF2, EPO, FGA, PF4, PPBP, SELP
9cuprophan4410.6SELP, EPO, SERPINF2, FGA, PF4, LIF
10ristocetin4410.6SELP, SERPINF2, GP1BA, PPBP, EPO
11methylcellulose4410.6THPO, IL6, IL11, IL3, EPO, LIF
12hirudin4410.6FGA, GP1BA, PF4, THPO, SELP, SERPINF2
13polysulfone4410.6SELP, PPBP, EPO, PF4, FGA, CRP
14ptca4410.5PF4, PPBP, FGA, SELP, SERPINF2
15thromboxane44 2411.5SERPINF2, SELP, THPO, FGA, NFE2, PPBP
16txb24410.5IL11, SELP, LIF, PPBP, SERPINF2, PF4
17desmopressin44 59 28 1113.5EPO, GP1BA, SELP, SERPINF2, PPBP
18iohexol4410.5SELP, FGA, PPBP, PF4
19thromboxane a244 2411.5LIF, FGA, THPO, SELP, PF4, PPBP
20latex4410.5PPBP, GP1BA, CRP, PF4, FGA, THPO
21glucose4410.5PF4, CEBPB, PPBP, LIF, IL11, GP1BA
22rantes4410.5IL11, IL6, PPBP, LIF, PF4, IL3
23gp 1304410.4MPL, CEBPB, THPO, IL6, JAK2, LIF
24prostacyclin4410.4FGA, PPBP, PF4, IL3, GP1BA, THPO
25hydroxyurea44 49 1112.4EPO, THPO, IL3, PF4, JAK2, PPBP
2611-dehydrothromboxane b24410.4PPBP, PF4, SELP, FGA
27heparin44 28 11 2413.4SELP, IL11, PPBP, THPO, GP1BA, LIF
28epinephrine44 11 2412.4SELP, PF4, FGA, IL11, JAK2, PPBP
29aspirin44 49 28 2413.4CEBPB, PPBP, JAK2, CRP, SELP, THPO
30ly2940024410.4EPO, IL3, THPO, IL6, CRP, JAK2
31agar4410.4JAK2, PF4, IL3, THPO, EPOR, MPL
32histamine44 28 2412.4PF4, PPBP, FGA, IL3, SELP, IL11
33actinomycin d4410.4EPOR, THPO, NFE2, LIF, IL3, JAK2
34indomethacin44 59 28 1113.4PF4, CEBPB, GP1BA
35thymidine44 2411.4FGA, LIF, JAK2, PPBP, PF4, IL3
36lactate4410.3SELP, CRP, EPO, PF4, FGA, LIF
37creatinine4410.3EPO, CRP, PPBP, SELP, THPO, IL6
38oxygen44 2411.3JAK2, PF4, IL11, SERPINF2, CEBPB, EPO
39dexamethasone44 49 28 1113.3IL3, PPBP, CEBPB, IL6, LIF
40alanine4410.3IL11, SERPINF2, EPOR, MPL, CRP, PF4
41fibrinogen4410.3PPBP, PF4, FGA, IL11, IL6, GP1BA
42phosphatidylinositol4410.3IL3, LIF, CEBPB, THPO, PPBP, GP1BA
43amifostine44 1111.3IL3, EPO, IL11, THPO
44vegf4410.3CRP, JAK2, PPBP, THPO, MPL, LIF
45cholesterol44 28 11 2413.2JAK2, PPBP, FGA, LIF, PF4, CRP
46tyrosine4410.1IL11, MPL, JAK2, PPBP, CEBPB, LIF
47cysteine4410.1SELP, PPBP, PF4, LIF, MPL, JAK2
48tgf beta14410.1PPBP, LIF, THPO, PF4, IL6, IL11
49nitric oxide44 11 2412.0PPBP, IL11, CEBPB, SELP, THPO, JAK2
506-ketoprostaglandin f1alpha4410.0PPBP, PF4, FGA, SERPINF2

GO Terms for genes affiliated with Thrombocytosis

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16Gene Ontology
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Cellular components related to Thrombocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:00557710.4SERPINF2, FGA
2platelet alpha granule lumenGO:03109310.0PPBP, PF4, FGA, SERPINF2
3extracellular spaceGO:0056159.9SERPINF2, PPBP, CRP, LIF, EPO, PF4
4extracellular regionGO:0055769.9EPOR, EPO, CRP, PPBP, PF4, FGA

Biological processes related to Thrombocytosis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.6IL3, EPO, JAK2
2negative regulation of hormone secretionGO:04688810.6LIF, IL11, IL6
3positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.6IL6, LIF, JAK2
4tyrosine phosphorylation of Stat3 proteinGO:04250310.6LIF, JAK2
5acute-phase responseGO:00695310.6CRP, IL6, SERPINF2, CEBPB
6positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5JAK2, LIF, IL3, IL11, IL6
7positive regulation of DNA replicationGO:04574010.5EPO, IL3, IL6
8platelet degranulationGO:00257610.5PPBP, PF4, FGA, SELP, SERPINF2
9response to lipopolysaccharideGO:03249610.5JAK2, EPO, IL6, SELP, CEBPB
10positive regulation of peptidyl-serine phosphorylationGO:03313810.5IL6, IL11, LIF
11negative regulation of lipid storageGO:01088810.4IL6, CRP
12positive regulation of MAPK cascadeGO:04341010.4LIF, IL11, IL6
13positive regulation of cell proliferationGO:00828410.4JAK2, LIF, EPO, IL3, IL11, IL6
14positive regulation of macrophage differentiationGO:04565110.4LIF, PF4
15platelet activationGO:03016810.3SERPINF2, PPBP, MPL, PF4, FGA, IL11
16positive regulation of protein import into nucleus, translocationGO:03316010.3IL6, JAK2
17blood coagulationGO:00759610.3PPBP, JAK2, MPL, NFE2, CD177, PF4
18inflammatory responseGO:00695410.3CEBPB, SELP, IL6, CRP
19agingGO:00756810.0CRP, EPO, IL6

Molecular functions related to Thrombocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.2THPO, IL6, IL11, IL3, LIF
2growth factor activityGO:0080839.9THPO, PPBP, LIF, IL3, IL11, IL6

Products for genes affiliated with Thrombocytosis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Thrombocytosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet