MCID: THR004
MIFTS: 59

Thrombocytosis malady

Cancer diseases, Blood diseases categories

Summaries for Thrombocytosis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A myeloma and blood platelet disease that is characterized by the presence of high platelet counts in the blood.

MalaCards: Thrombocytosis, also known as platelet count above reference range, is related to refractory anemia and myelofibrosis. An important gene associated with Thrombocytosis is THPO (thrombopoietin), and among its related pathways are Paxillin-dependent events mediated by a4b1 and Development EPO induced Jak STAT pathway. The drugs chlorambucil and uracil mustard and the compounds megapoietin and pp 100 have been mentioned in the context of this disorder. Affiliated tissues include myeloid, lung and bone marrow, and related mouse phenotypes are cellular and immune system.

Wikipedia:66 Thrombocytosis (or thrombocythemia) is the presence of high platelet counts in the blood, and can be... more...

Aliases & Classifications for Thrombocytosis

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Aliases & Descriptions:

thrombocytosis 9 11 46 63
platelet count above reference range 9
thrombocythaemia 9
thrombocythemia 9


External Ids:

Disease Ontology9 DOID:2228
MeSH36 D013922
NCIt41 C35530

Related Diseases for Thrombocytosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Thrombocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 254)
idRelated DiseaseScoreTop Affiliating Genes
1refractory anemia30.8THPO, MPL, EPOR, JAK2
2myelofibrosis30.6THPO, JAK2
3myeloid leukemia30.6JAK2, MPL, THPO
4polycythemia30.5CD177, MPL, EPOR, THPO, JAK2
5polycythemia vera30.5THPO, CD177, MPL, EPOR, JAK2
6deficiency anemia30.5IL6, THPO, JAK2, EPOR, MPL
7myocardial infarction30.4GP1BA, SERPINF2, FGA
8thrombocytopenia30.4FGA, IL6, MPL, THPO, GP1BA
9thromboembolism30.4FGA, SERPINF2
10leukemia30.4EPOR, THPO, MPL, SERPINF2, IL6, CD177
11myeloproliferative disorder30.3EPOR, MPL, CD177, THPO, JAK2
12thrombocythemia 130.3THPO
13hemorrhagic thrombocythemia30.3THPO, MPL, CD177, JAK2
14purpura30.3THPO
15chronic myeloid leukemia30.3CD177, MPL, JAK2, THPO, EPOR
16megakaryocytic leukemia30.3EPOR, THPO
17myelodysplastic syndromes30.2MPL, GP1BA, THPO, CD177, JAK2, EPOR
18venous thrombosis30.2SERPINF2, JAK2, FGA
19erythrocytosis30.2CD177, JAK2, EPOR, MPL
20splenomegaly30.1THPO, MPL, JAK2
21chronic myelomonocytic leukemia29.9MPL, JAK2
22ischemia29.9EPOR, FGA, JAK2
23autoimmune thrombocytopenic purpura29.9MPL, THPO
24pancytopenia29.9MPL, THPO
25aplastic anemia29.9THPO, GP1BA, MPL
26chronic myeloproliferative disease29.8JAK2, MPL, THPO
27hepatoblastoma29.8THPO, MPL, EPOR
28myeloma29.7JAK2, IL6, EPOR
29pulmonary embolism29.7FGA, SERPINF2
30sickle cell disease29.7EPOR, FGA
31vascular disease29.7SERPINF2, IL6, JAK2
32thrombophilia29.7FGA, SERPINF2
33coronary artery disease29.7FGA, JAK2, EPOR
34systemic lupus erythematosus29.7MPL, FGA, IL6
35diabetes mellitus29.7IL6, GP1BA, FGA
36atherosclerosis29.7IL6, SERPINF2, FGA
37nephrotic syndrome29.7SERPINF2, FGA
38acute leukemia29.6THPO, JAK2, FGA, MPL, EPOR
39essential thrombocythemia10.5
40iron deficiency anemia10.4
41ovarian cancer10.4
42lung cancer10.4
43renal cell carcinoma10.3
44pneumonia10.3
45coronary thrombosis10.2
46arthritis10.2
47chronic lymphocytic leukemia10.2
48hypercalcemia10.2
49rheumatoid arthritis10.2
50sarcoma10.2

Graphical network of the top 20 diseases related to Thrombocytosis:



Diseases related to thrombocytosis

Symptoms for Thrombocytosis

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Drugs & Therapeutics for Thrombocytosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Thrombocytosis

Drug clinical trials:

Search ClinicalTrials for Thrombocytosis

Search NIH Clinical Center for Thrombocytosis

Search CenterWatch for Thrombocytosis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Thrombocytosis

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Anatomical Context for Thrombocytosis

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34MalaCards
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MalaCards organs/tissues related to Thrombocytosis:

34
Myeloid, Lung, Bone marrow, Bone, Liver, Breast, Heart, Thyroid, Whole blood, Skin, Spleen, Endothelial, Testes, Lymph node, Colon, Ovary, Placenta, Tongue

Animal Models for Thrombocytosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Thrombocytosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.2IL6, JAK2, EPOR, MPL, GP1BA
2MP:00053877.3THPO, MPL, EPOR, JAK2, IL6, FGA
3MP:00053977.1FGA, THPO, GP1BA, MPL, EPOR, JAK2
4MP:00053766.7GP1BA, MPL, SERPINF2, EPOR, JAK2, IL6

Publications for Thrombocytosis

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Sources:
53PubMed
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Articles related to Thrombocytosis:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer. (23080345)
2013
2
Impressive thrombocytosis evolving in a patient with a BCR-ABL positive CML in major molecular response during dasatinib treatment unmasks an additional JAK2V617F. (24007855)
2013
3
Plateletpheresis for postsplenectomy rebound thrombocytosis in a patient with chronic immune thrombocytopenic purpura on romiplostim. (23450778)
2013
4
The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer. (24285160)
2013
5
Iron deficiency generates secondary thrombocytosis and platelet activation in IBD: the randomized, controlled thromboVIT trial. (23644823)
2013
6
Preoperative anemia, leukocytosis and thrombocytosis identify aggressive endometrial carcinomas. (24004646)
2013
7
EXEL-8232, a small-molecule JAK2 inhibitor, effectively treats thrombocytosis and extramedullary hematopoiesis in a murine model of myeloproliferative neoplasm induced by MPLW515L. (22005786)
2012
8
Chronic myeloid leukemia with extreme thrombocytosis. (22479272)
2012
9
Absence of JAK2V617F mutation in patients with beta-thalassemia major and thrombocytosis due to splenectomy. (22203487)
2012
10
Impact of pretreatment thrombocytosis on blood-borne metastasis and prognosis of gastric cancer. (22592098)
2012
11
Teaching NeuroImages: disappearing intraluminal thrombus of the carotid artery in reactive thrombocytosis. (21502592)
2011
12
Thrombocytosis in children. (22075805)
2011
13
The impact of pretreatment thrombocytosis and persistent thrombocytosis after adjuvant chemotherapy in patients with advanced epithelial ovarian cancer. (21531448)
2011
14
Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis. (19903679)
2010
15
Cholestatic hepatitis and thrombocytosis in a secondary syphilis patient. (21060758)
2010
16
The role of the Platelet Function Analyzer (PFA)-100 and platelet aggregometry in the differentiation of essential thrombocythemia from reactive thrombocytosis. (19664802)
2010
17
Geminin deletion from hematopoietic cells causes anemia and thrombocytosis in mice. (21041951)
2010
18
The role of thrombocytosis in prognostic evaluation of epithelial ovarian tumors. (18470520)
2009
19
Isolated thrombocytosis as first sign of chronic myeloid leukemia with e6a2 BCR/ABL fusion transcript, JAK2 negativity and complete response to imatinib. (17688946)
2008
20
Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythemia. (18587010)
2008
21
Philadelphia chromosome-positive chronic myeloid leukemia with p190(BCR-ABL) rearrangement, overexpression of the EVI1 gene, and extreme thrombocytosis: a case report. (18262061)
2008
22
Aortic thrombus due to essential thrombocytosis: strategies for medical and surgical management. (18513483)
2008
23
Pulmonary hypertension in patients with essential thrombocythemia and reactive thrombocytosis. (17852711)
2007
24
Thrombocytosis induced in mice after subacute and subchronic V2O5 inhalation. (16716040)
2006
25
Extreme thrombocytosis: what are the etiologies? (16444439)
2006
26
Patterns of thrombocytosis and thrombocytopenia in hospitalized neonates. (15578031)
2005
27
Primary and secondary thrombocytosis in childhood. (15813844)
2005
28
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. (16293924)
2005
29
The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis. (13679323)
2003
30
Essential thrombocytosis causing a massive myocardial infarction. (12826291)
2003
31
Philadelphia chromosome and/or bcr-abl mRNA-positive primary thrombocytosis: morphometric evidence for the transition from essential thrombocythaemia to chronic myeloid leukaemia type of myeloproliferation. (12493025)
2003
32
Reactive thrombocytosis alone does not affect the patency of microvascular anastomosis in the splenectomy rat. (12172143)
2002
33
Bloodstream thrombopoietin in rheumatoid arthritis with thrombocytosis. (12447626)
2002
34
Thrombocytosis in children with iron deficiency anemia: series of 42 children. (12368707)
2002
35
Thrombocytosis is associated with a significant increase in the cancer specific death rate after radical nephrectomy. (12352397)
2002
36
Pseudohyperkalemia occurring in a patient with chronic renal failure and polycythemia vera without severe leukocytosis or thrombocytosis. (12508968)
2002
37
Familial thrombocytosis as a recessive, possibly X-linked trait in an Arab family. (11260062)
2001
38
Extreme self-limited thrombocytosis in a young patient. (11669311)
2001
39
Preoperative thrombocytosis is an independent prognostic factor in stage III and IV endometrial cancer. (11268488)
2000
40
Rapid reduction of platelet numbers in thrombocytosis. (11111819)
2000
41
Use of a platelet filter test in patients with thrombocytosis. (10938880)
2000
42
Leucocytosis, thrombocytosis, and plasma osmolality during rest and exercise: an hypothesis. (10424721)
1999
43
The observation of reactive thrombocytosis in New Zealand white rabbits in response to experimental Pasteurella multocida infection. (10389591)
1999
44
Prolonged extreme thrombocytosis associated with neurofibromatosis type 1. (9042140)
1997
45
Elevated plasma thrombopoietic activity in patients with metastatic cancer-related thrombocytosis. (7539977)
1995
46
Establishment and characterization of a new human mesothelioma cell line (T-85) from malignant peritoneal mesothelioma with remarkable thrombocytosis. (8581142)
1995
47
High IL-6 levels in ascitic fluid correlate with reactive thrombocytosis in patients with epithelial ovarian cancer. (8485049)
1993
48
Serum interleukin-6 levels in patients with thrombocytosis. (1490150)
1992
49
Thrombocytosis and hyposplenism in an infant with fetal hydantoin syndrome. (1550265)
1992
50
Interleukin-1 beta (IL-1 beta) induces thrombocytosis in mice: possible implication of IL-6. (2265245)
1990

Variations for Thrombocytosis

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Expression for genes affiliated with Thrombocytosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thrombocytosis

Search GEO for disease gene expression data for Thrombocytosis.

Pathways for genes affiliated with Thrombocytosis

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 55R&D Systems, 5Cell Signaling Technology, 54QIAGEN, 31KEGG
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Pathways related to Thrombocytosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b739
a4b1 and a4b7 Integrin signaling39
9.6JAK2, EPOR
2
Show member pathways
EPO Receptor Signaling39
EPO signaling pathway39
9.6EPOR, JAK2
3
Show member pathways
9.5JAK2, IL6
49.5IL6, JAK2
59.5JAK2, IL6
6
Show member pathways
IL27-mediated signaling events39
9.5JAK2, IL6
7
Show member pathways
9.5IL6, JAK2
8
Show member pathways
9.5IL6, JAK2
99.4IL6, GP1BA
10
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.4MPL, THPO, JAK2
11
Show member pathways
9.2IL6, JAK2, THPO
12
Show member pathways
9.2IL6, THPO, EPOR
13
Show member pathways
9.2THPO, EPOR, IL6
149.1EPOR, JAK2, IL6
15
Show member pathways
9.1IL6, JAK2, EPOR
16
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.0FGA, SERPINF2
17
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
8.9JAK2, MPL, IL6, THPO
18
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
8.8EPOR, JAK2, FGA
19
Show member pathways
8.8IL6, JAK2, EPOR, THPO
20
Show member pathways
8.8IL6, THPO, EPOR, JAK2
21
Show member pathways
8.8JAK2, IL6, THPO, EPOR
22
Show member pathways
8.7MPL, EPOR, JAK2, IL6
23
Show member pathways
Type III interferon signaling39
8.7EPOR, JAK2, IL6, MPL
248.7THPO, GP1BA, EPOR, IL6
25
Show member pathways
8.5SERPINF2, FGA, GP1BA
26
Show member pathways
8.5MPL, THPO, FGA, GP1BA
27
Show member pathways
8.4JAK2, THPO, MPL, EPOR, IL6
28
Show member pathways
7.1THPO, CD177, JAK2, SERPINF2, MPL, GP1BA

Compounds for genes affiliated with Thrombocytosis

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 52PharmGKB
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Compounds related to Thrombocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1megapoietin4610.2MPL, THPO
2pp 1004610.0EPOR, JAK2
3pixy321469.9IL6, THPO
4filgrastim46 1210.9THPO, IL6
5anagrelide46 1210.8JAK2, THPO, MPL
6phorbol 12,13-dibutyrate469.8JAK2, THPO
7polyethylene469.7FGA, THPO
8methylcellulose469.6THPO, EPOR, IL6
9ristocetin469.6GP1BA, SERPINF2
10gm-csf46 3010.5IL6, THPO
11fibrinopeptide a469.4FGA, SERPINF2
12agar469.4EPOR, MPL, THPO, JAK2
13sb 20358046 6210.3THPO, JAK2, IL6
14desmopressin46 62 30 1212.3SERPINF2, GP1BA
156-ketoprostaglandin f1alpha469.3FGA, SERPINF2
16asparagine469.2SERPINF2, EPOR, GP1BA
17ptca469.2SERPINF2, FGA
18cuprophan469.2SERPINF2, FGA
19latex469.2FGA, THPO, GP1BA
20ly294002469.2EPOR, IL6, JAK2, THPO
21actinomycin d469.1JAK2, IL6, EPOR, THPO
22lysine469.1MPL, SERPINF2, JAK2, THPO
23prostacyclin469.1THPO, GP1BA, FGA
24indomethacin46 30 62 1212.1GP1BA, JAK2, IL6, THPO
25oligonucleotide469.0EPOR, THPO, GP1BA, JAK2
26nitric oxide46 25 1211.0EPOR, JAK2, THPO, IL6
27gp 130468.9IL6, JAK2, EPOR, MPL, THPO
28phosphatidylinositol468.8THPO, GP1BA, MPL, EPOR, JAK2
29thromboxane46 259.8SERPINF2, FGA, MPL, THPO
30phenylalanine468.7EPOR, GP1BA, JAK2, FGA
31oxygen46 259.7EPOR, JAK2, SERPINF2, THPO
32hirudin468.6THPO, FGA, GP1BA, SERPINF2
33lactate468.6IL6, GP1BA, THPO, FGA
34glucose468.6THPO, JAK2, GP1BA, IL6, EPOR
35endotoxin468.5FGA, SERPINF2, IL6, JAK2
36heparin46 30 25 1211.5GP1BA, THPO, FGA, SERPINF2
37aspirin46 52 30 2511.5THPO, GP1BA, MPL, JAK2, FGA
38estrogen468.5JAK2, EPOR, THPO, IL6
39aprotinin46 129.4SERPINF2, FGA, IL6, GP1BA
40cholesterol46 30 25 1211.4FGA, IL6, JAK2, SERPINF2
41thymidine46 259.4FGA, IL6, JAK2, EPOR, THPO
42vegf468.2JAK2, IL6, THPO, SERPINF2, EPOR, MPL
43fibrinogen468.1GP1BA, IL6, FGA, SERPINF2, THPO
44lipid468.0FGA, IL6, SERPINF2, JAK2, EPOR
45adp46 30 259.9GP1BA, FGA, JAK2, SERPINF2, THPO, MPL
46alanine467.7THPO, IL6, JAK2, EPOR, SERPINF2, MPL
47epinephrine46 25 129.7SERPINF2, GP1BA, THPO, JAK2, IL6, FGA
48serine467.7FGA, EPOR, SERPINF2, MPL, GP1BA, JAK2
49calcium46 52 25 1210.7EPOR, JAK2, SERPINF2, GP1BA, THPO, FGA
50tyrosine467.1THPO, GP1BA, MPL, EPOR, FGA, CD177

GO Terms for genes affiliated with Thrombocytosis

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17Gene Ontology
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Cellular components related to Thrombocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.0FGA, SERPINF2
2fibrinogen complexGO:0055778.9FGA, SERPINF2
3extracellular spaceGO:0056157.9FGA, IL6, SERPINF2, THPO

Biological processes related to Thrombocytosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein import into nucleus, translocationGO:0331609.8IL6, JAK2
2positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.8JAK2, IL6
3positive regulation of nitric oxide biosynthetic processGO:0454299.7IL6, JAK2
4response to antibioticGO:0466779.7JAK2, IL6
5positive regulation of cell differentiationGO:0455979.6JAK2, SERPINF2
6fibrinolysisGO:0427309.6SERPINF2, GP1BA
7acute-phase responseGO:0069539.4IL6, SERPINF2
8positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4IL6, JAK2
9positive regulation of smooth muscle cell proliferationGO:0486619.4SERPINF2, IL6
10positive regulation of protein kinase B signalingGO:0518979.3IL6, THPO
11positive regulation of ERK1 and ERK2 cascadeGO:0703749.3THPO, SERPINF2, IL6
12response to calcium ionGO:0515929.1FGA, IL6
13platelet degranulationGO:0025769.0FGA, SERPINF2
14platelet activationGO:0301687.6THPO, GP1BA, MPL, SERPINF2, IL6, FGA
15blood coagulationGO:0075967.4FGA, THPO, GP1BA, MPL, SERPINF2, JAK2

Products for genes affiliated with Thrombocytosis

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  • Antibodies
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Sources for Thrombocytosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet