Thrombocytosis malady

Disease Ontology: A myeloma and blood platelet disorder that is characterized by the presence of high platelet counts in the blood.⁶

MalaCards: Thrombocytosis, also known as thrombocythemia, is related to essential thrombocythemia and myelofibrosis. An important gene associated with Thrombocytosis is THCYTX (Thrombocytosis, familial X-linked), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Ras Pathway. The drugs chlorambucil and uracil mustard and the compounds anagrelide and pixy321 have been mentioned in the context of this disorder. Affiliated tissues include lung, myeloid and t cells, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia: Thrombocytosis (or thrombocythemia) is the presence of high platelet counts in the blood, and can be...⁴⁴ more...

Aliases & Descriptions:

thrombocytosis 6 7 8 32 43 thrombocythemia 6 7 platelet count above reference range 6 thrombocythaemia (disorder) 6

thrombocythemia (finding) 6 thrombocytosis (disorder) 6 thrombocythaemia 6

Diseases related to thrombocytosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 800)

id	Related Disease	Score	Top Affiliating Genes
1	essential thrombocythemia	32.4	MPL, JAK2, THPO
2	myelofibrosis	31.0	JAK2, CD177, THPO, EPO
3	thrombocytosis, familial x-linked	30.0	FTX, THCYTX
4	hemorrhagic thrombocythemia	29.5	ZNF77, MPL, JAK2, CD177, THPO
5	iron deficiency anemia	29.0	SELP, IL11, ALB, THPO, CSF3, EPO
6	thrombosis	28.3	MTHFR, F8, F5, F2
7	cyclic thrombocytopenia	28.2	IL3, IL6, THPO
8	erythromelalgia	28.0	PPBP, PF4, EIF4ENIF1, THBD
9	acquired von willebrand syndrome	27.6	VWF, CD40LG, F8, F3, F2
10	malignant mesothelioma	27.5	KITLG, VEGFA, IL6, IFNA2, CALB2, PDGFRB
11	pulmonary tuberculosis	27.0	IL4, HP, PF4, CXCL12
12	erythrocytosis	26.9	KITLG, SELP, MPL, JAK2, CD177, IL11
13	chronic lymphocytic leukemia	26.7	JAK2, CD40LG, FLT3, IL4, THPO, CXCL12
14	paraneoplastic syndromes	26.6	CD79A, IL6, ALB, THPO, CSF3
15	acute promyelocytic leukemia	26.5	RARS, CEBPB, FLT3, IL3, F3, THBD
16	inflammatory bowel disease	26.4	SELP, JAK2, IL11, IL1B, IL4, IL6
17	ischemic optic neuropathy	26.4	VEGFA, MTHFR, GP1BA, F5, F2, CRP
18	hypercalcemia	26.4	LIF, IL1A, IL1B, IL3, IL6, ALB
19	polycythemia vera	26.4	KITLG, VWF, SELP, SERPINC1, MPL, JAK1
20	hepatoblastoma	26.3	KITLG, SERPINA7, LIF, CEBPB, MPL, IL1A
21	splenomegaly	25.9	VEGFA, MPL, JAK2, IFNA1, IFNA2, HP
22	myeloproliferative disorder	25.8	KITLG, VWF, SELP, MPL, JAK2, CD177
23	thromboembolism	25.8	VWF, SELP, SERPINC1, SERPINF2, MTHFR, FGA
24	chronic myeloproliferative disease	25.5	VEGFA, MTHFR, MPL, JAK2, CD177, FLT3
25	epithelial ovarian cancer	25.4	VEGFA, MTHFR, AR, IL3, IL6, IFNA2
26	polycythemia	25.3	KITLG, VWF, SELP, SERPINC1, VEGFA, MPL
27	chronic myeloid leukemia	25.2	KITLG, SELP, CEBPB, MPL, JAK2, CD177
28	neurofibromatosis	25.1	KITLG, VEGFA, IL6, NF1, RUNX1, EPOR
29	juvenile rheumatoid arthritis	25.1	VEGFA, CD79A, IL1A, IL1B, IL6, IFNA1
30	thrombophilia	24.8	VWF, SELP, SERPINC1, SERPINF2, MTHFR, JAK2
31	renal cell carcinoma	24.6	SELP, VEGFA, FLT3, IL4, IFNA1, IFNA2
32	psoriatic arthritis	24.5	VEGFA, MTHFR, CD79A, CD40LG, IL1A, IL1B
33	aplastic anemia	23.7	KITLG, VEGFA, MPL, CD79A, CD40LG, FLT3
34	celiac disease	23.5	MTHFR, CD79A, CD40LG, IL1A, IL1B, IL4
35	kawasaki disease	23.2	VWF, SELP, VEGFA, MPL, CD79A, CD40LG
36	noma	23.2	VEGFA, IL1A, IL1B, IL3, IL4, IL6
37	meningitis	22.7	VEGFA, CD79A, CD40LG, IL1A, IL1B, IL4
38	pulmonary hypertension	22.6	VWF, SELP, SERPINC1, VEGFA, JAK2, CD40LG
39	hematopoiesis	22.2	KITLG, VEGFA, RARS, LIF, MPL, JAK2
40	thrombocytopenia	21.8	KITLG, VWF, SELP, SERPINC1, MTHFR, MPL
41	anemia	21.4	KITLG, VWF, SELP, SERPINC1, SERPINA7, VEGFA
42	purpura	20.9	VWF, SELP, SERPINC1, SERPINF2, VEGFA, MTHFR
43	acute leukemia	20.3	KITLG, VWF, SELP, SERPINC1, SERPINF2, VEGFA
44	tuberculosis	20.2	SERPINC1, SERPINA7, SERPINF2, VEGFA, RARS, CEBPB
45	neuropathy	19.5	VWF, VEGFA, LIF, MTHFR, CD79A, CD40LG
46	arthritis	19.1	KITLG, VWF, SELP, SERPINC1, SERPINA7, SERPINF2
47	lymphocytic leukemia	19.1	KITLG, SELP, SERPINC1, VEGFA, MTHFR, JAK1
48	rheumatoid arthritis	19.0	KITLG, VWF, SELP, SERPINC1, SERPINA7, SERPINF2
49	myeloid leukemia	18.9	KITLG, VWF, SELP, SERPINF2, VEGFA, RARS
50	pneumonia	18.9	SERPINC1, SERPINF2, VEGFA, LIF, MTHFR, CD79A

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 chlorambucil, uracil mustard

MalaCards organs/tissues related to thrombocytosis:

²²

MGI Mouse Phenotypes related to thrombocytosis:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.5	CPB2, NF1, TBXA2R, LIF, SELP
2	endocrine/exocrine gland phenotype	MP:0005379	9.5	NF1, CD40LG
3	embryogenesis phenotype	MP:0005380	9.3	EPOR, RUNX1, CSF2, NF1, F2, MECOM
4	renal/urinary system phenotype	MP:0005367	9.1	CPB2, PDGFRB, NF1, TET2, AR, CEBPB
5	hematopoietic system phenotype	MP:0005397	8.6	THPO, CSF2, CSF3, CSF3R, RUNX1, EPO
6	liver/biliary system phenotype	MP:0005370	8.6	EPO, RUNX1, NF1, TET2, IL6, MECOM
7	skeleton phenotype	MP:0005390	8.5	RUNX1, CSF2, TYMP, NFE2, IL6, FGA
8	reproductive system phenotype	MP:0005389	8.4	CSF2, TBXA2R, F10, F8, IL6, IL4
9	tumorigenesis	MP:0002006	8.4	HP, TET2, NF1, NFE2, CSF2, CPB2
10	integument phenotype	MP:0010771	8.2	F2, NF1, NFE2, CSF2, CSF3, RUNX1
11	nervous system phenotype	MP:0003631	7.8	F2, CALB2, NF1, TYMP, THBD, CXCL12
12	vision/eye phenotype	MP:0005391	7.5	NF1, F3, IL6, IL4, FGA, CEBPB
13	growth/size phenotype	MP:0005378	7.1	F3, TPO, TET2, NF1, NFE2, PDGFRB
14	immune system phenotype	MP:0005387	7.0	CSF2, CSF3R, CPB2, RUNX1, EPOR, TYMP
15	cardiovascular system phenotype	MP:0005385	6.0	NF1, CRP, TBXA2R, TET2, HP, NFE2
16	normal phenotype	MP:0002873	5.3	HMGCR, TET2, NF1, PDGFRB, THBD, RUNX1
17	mortality/aging	MP:0010768	4.8	KITLG, VWF, SELP, SERPINC1, VEGFA, MTHFR
18	cellular phenotype	MP:0005384	4.7	NF1, TET2, HP, F2, F3, GP1BA
19	homeostasis/metabolism phenotype	MP:0005376	3.4	KITLG, MECOM, IL1A, IL3, GP1BA, F8

Articles related to thrombocytosis:

(show top 50)    (show all 123)

id	Title	Authors	Year	Affiliating Genes
1	Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: analysis of molecular genetics and clinical phenotypes. (21712540)	Stein B.L.... Moliterno A.R.	2011	ASXL1
2	Class prediction models of thrombocytosis using genet ic biomarkers. (19773543)	Gnatenko D.V.... Bahou W.F.	2010	JAK2
3	Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis. (20154217)	Koppikar P.... Levine R.L.	2010	JAK2
4	Narrative review: Thrombocytosis, polycythemia vera, and JAK2 mutations: The phenotypic mimicry of chronic myeloproliferation. (20194236)	Spivak J.L.	2010	JAK2, THPO, CSF3
5	Granulocytosis and thrombocytosis in renal cell carci noma: a pro-inflammatory cytokine response originating in the tumour. (19581670)	van Rossum A.P.... Castel A.	2009	CRP, THPO, CSF3
6	Thrombocytosis in EPO-treated dialysis patients may be mediated by EPO rather than iron deficiency. (19303685)	Vaziri N.D.	2009	EPO
7	Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis. (18796624)	Lannutti B.J.... Josephson N.C.	2009	MPL
8	Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis. (19692701)	Malcovati L.... Cazzola M.	2009	JAK2
9	Familial thrombocytosis caused by the novel germ-line mutation p.Pro106Leu in the MPL gene. (19036112)	El-Harith e.l.-.H.A.... Stuhrmann M.	2009	THPO, MPL
10	A case of IL-6 producing malignant mesothelioma of abdomen with thrombocytosis. (19346724)	Fukuyama T.... Nojima T.	2009	IL6, CALB2
11	JAK2V617F mutation status identifies subtypes of refractory anemia with ringed sideroblasts associated with marked thrombocytosis. (18166783)	Schmitt-Graeff A.H.... Skoda R.C.	2008	JAK2
12	Isolated thrombocytosis as first sign of chronic myeloid leukemia with e6a2 BCR/ABL fusion transcript, JAK2 negativity and complete response to imatinib. (17688946)	Breccia M.... Alimena G.	2008	JAK2
13	Prognostic interaction between thrombocytosis and JAK2 V617F mutation in the WHO subcategories of myelodysplastic/myeloproliferative disease-unclassifiable and refractory anemia with ringed sideroblasts and marked thrombocytosis. (18059483)	Atallah E.... Verstovsek S.	2008	JAK2
14	Refractory anemia with ringed sideroblasts associated with thrombocytosis: comparative analysis of marked with non-marked thrombocytosis, and relationship with JAK2 V617F mutational status. (18820995)	Raya J.M.... Florensa L.	2008	JAK2
15	Erythropoietin, iron depletion, and relative thrombocytosis: a possible explanation for hemoglobin-survival paradox in hemodialysis. (18760517)	Streja E.... Kalantar-Zadeh K.	2008	EPO
16	Bortezomib is an effective agent for MDS/MPD syndrome with 5q- anomaly and thrombocytosis. (16820206)	Terpos E.... Zervas K.	2007	IL6
17	Uncontrolled thrombocytosis in polycythemia vera is a risk for thrombosis, regardless of JAK2(V617F) mutational status. (17611562)	Ohyashiki K.... Ohyashiki J.H.	2007	JAK2
18	High occurrence of JAK2 V617 mutation in refractory anemia with ringed sideroblasts associated with marked thrombocytosis. (16990759)	Renneville A.... Preudhomme C.	2006	JAK2
19	Impact of thrombocytosis and C-reactive protein elevation on the prognosis for patients with renal cell carcinoma. (17083384)	Ito K.... Hayakawa M.	2006	IL6, CRP
20	Androgen mediation of thrombocytosis in epithelial ovarian cancer biology. (16299230)	Li A.J.... Karlan B.Y.	2005	AR
21	Thrombopoietin and interleukin-6 in children with pneumonia-associated thrombocytosis. (15847944)	Dodig S.... Cepelak I.	2005	IL6, THPO
22	Thrombocytosis in an infant with high thrombopoietin concentrations. (14767209)	Hankins J.... Rodriguez-Galindo C.	2004	THPO
23	Serum thrombopoietin levels in patients with reactive thrombocytosis due to lung cancer and in patients with essential thrombocythemia. (14689068)	Werynska B.... Kuliczkowski K.	2003	THPO
24	Cross-reactivity between erythropoietin and thrombopoietin at the level of Mpl does not account for the thrombocytosis seen in iron deficiency. (14608207)	Geddis A.E.... Kaushansky K.	2003	THPO, MPL, EPO
25	Levels of serum cytokines and acute phase proteins in patients with essential and cancer-related thrombocytosis. (12714883)	Alexandrakis M.G.... Kyriakou D.S.	2003	CRP
26	EPO and TPO sequences do not explain thrombocytosis in iron deficiency anemia. (14608206)	Racke F.K.	2003	THPO, EPO
27	Bloodstream thrombopoietin in rheumatoid arthritis with thrombocytosis. (12447626)	Kiraz S.... Calguneri M.	2002	THPO
28	Increased erythropoietin levels in reactive thrombocytosis. (12243556)	BalAsik O.S.... Kirazli S.	2002	THPO, EPO
29	Circulating thrombopoietin in clonal versus reactive thrombocytosis. (12171772)	Karakus S.... Dundar S.V.	2002	THPO, EPO
30	The role of thrombopoietin in post-operative thrombocytosis. (11472357)	Folman C.C.... von dem Borne A.E.	2001	THPO, IL11
31	Familial thrombocytosis as a recessive, possibly X-linked trait in an Arab family. (11260062)	Stuhrmann M.... el-Harith E.A.	2001	THPO, THCYTX
32	Thrombopoietic cytokines in patients with iron deficiency anemia with or without thrombocytosis. (10940653)	Akan H.... Dalva K.	2000	THPO, EPO, IL11
33	Elevated serum thrombopoietin and interleukin-6 concentrations in thrombocytosis associated with inflammatory bowel disease. (10454346)	Heits F.... Jelkmann W.	1999	IL6, THPO
34	Preoperative lipid-control with simvastatin reduces the risk of postoperative thrombocytosis and thrombotic complications following CABG. (10371111)	Christenson J.T.	1999	HMGCR
35	Elevation of serum thrombopoietin precedes thrombocytosis in Kawasaki disease. (9657430)	Ishiguro A.... Nakahata T.	1998	IL6, THPO
36	Blood thrombopoietin levels in clonal thrombocytosis and reactive thrombocytosis. (9626028)	Wang J.C.... Friedberg N.M.	1998	THPO
37	Prolonged extreme thrombocytosis associated with neurofibromatosis type 1. (9042140)	Hasle H.... Tommerup N.	1997	NF1
38	Thrombopoietin measurement in thrombocytosis: dysregulation and lack of feedback inhibition in essential thrombocythaemia. (9432045)	Pitcher L.... Rentoul A.	1997	THPO
39	Thrombocytosis after major lower extremity trauma: mechanism and possible role in free flap failure. (8743659)	Choe E.I.... Karpatkin M.	1996	IL6, THPO
40	Mechanism of thrombocytosis in hepatoblastoma: a case report. (8940737)	Yamaguchi H.... Miyazaki S.	1996	THPO
41	Safety and efficacy of picotamide, a dual anti-thromboxane agent, in patients with thrombocytosis and a previous thromboembolic event: a 1-year observational study. (8725994)	Pogliani E.... Milani M.	1996	TBXA2R
42	Cytokines affecting megakaryocytopoiesis in rheumatoid arthritis with thrombocytosis. (8783415)	Ertenli I.... Kirazhi S.	1996	IL6, IL1B, IL4
43	Refined chromosomal localization of the human thrombopoietin gene to 3q27-q28 and exclusion as the responsible gene for thrombocytosis in patients with rearrangements of 3q21 and 3q26. (8946927)	Schnittger S.... Fonatsch C.	1996	THPO, MECOM
44	Elevated plasma thrombopoietic activity in patients with metastatic cancer-related thrombocytosis. (7539977)	Estrov Z.... Kurzrock R.	1995	IL6, IL1B, IL3
45	Increased serum level of interleukin-6 in patients with psoriatic arthritis and thrombocytosis. (8586748)	Yasumoto S.... Hori Y.	1995	IL6
46	Interleukin-1 beta and interleukin-6 in clonal versus reactive thrombocytosis. (7493683)	Sayinalp N.... Kirazli S.	1995	IL6, IL1B
47	C-reactive protein in differential diagnosis of primary thrombocytosis (7739278)	PAcrez Encinas M.M.... Lete Achirica I.	1995	IL6
48	Role of interleukin-6 in paraneoplastic thrombocytosis. (8400277)	Blay J.Y.... Wijdenes J.	1993	IL6
49	Establishment of large cell lung cancer cell lines se creting hematopoietic factors inducing leukocytosis and thrombocytosis. (1281895)	Kimura H.... Sugita K.	1992	IL3
50	An abnormal pattern of multiple platelet function abnormalities and increased thromboxane generation in patients with primary thrombocytosis and thrombotic complications. (1836999)	Zahavi J.... Rachmani R.	1991	PPBP

Genes related to thrombocytosis according to GeneCards:

(show top 50)    (show all 67)

id	Symbol	Description	Score	GeneCards Section Context
1	THCYTX	Thrombocytosis, familial X-linked	11.0	Aliases & Descriptions, Publications, Disorders
2	FTX	FTX transcript, XIST regulator (non-protein coding)	11.0
3	THPO	thrombopoietin	11.0	Publications
4	MPL	myeloproliferative leukemia virus oncogene	11.0	Publications
5	CD177	CD177 molecule	11.0
6	JAK2	Janus kinase 2	11.0	Publications
7	NFE2	nuclear factor (erythroid-derived 2), 45kDa	11.0
8	IL11	interleukin 11	11.0	Publications
9	FGA	fibrinogen alpha chain	11.0	Publications
10	PF4	platelet factor 4	11.0	Publications
11	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
12	EPO	erythropoietin	11.0	Publications
13	EPOR	erythropoietin receptor	11.0
14	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.0
15	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
16	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	11.0
17	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	11.0
18	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
19	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
20	THBD	thrombomodulin	11.0
21	FLT3	fms-related tyrosine kinase 3	11.0
22	HP	haptoglobin	11.0
23	IFNA2	interferon, alpha 2	11.0	Publications
24	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
25	CRP	C-reactive protein, pentraxin-related	11.0	Publications
26	LIF	leukemia inhibitory factor	11.0
27	F10	coagulation factor X	11.0
28	KITLG	KIT ligand	11.0
29	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
30	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
31	VWF	von Willebrand factor	11.0
32	IL1A	interleukin 1, alpha	11.0	Publications
33	IL1B	interleukin 1, beta	11.0	Publications
34	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
35	ADAMTSL1	ADAMTS-like 1	11.0
36	F2	coagulation factor II (thrombin)	11.0	Publications
37	CXCL12	chemokine (C-X-C motif) ligand 12	11.0
38	IFNA1	interferon, alpha 1	11.0
39	HAGH	hydroxyacylglutathione hydrolase	11.0	Publications
40	ZNF77	zinc finger protein 77	11.0
41	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	11.0	Publications
42	CPB2	carboxypeptidase B2 (plasma)	11.0	Publications
43	TET2	tet methylcytosine dioxygenase 2	11.0	Publications
44	ASXL1	additional sex combs like 1 (Drosophila)	11.0	Publications
45	DPM1	dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit	11.0
46	EIF4ENIF1	eukaryotic translation initiation factor 4E nuclear import factor 1	11.0
47	TBXA2R	thromboxane A2 receptor	11.0	Publications
48	CSF3R	colony stimulating factor 3 receptor (granulocyte)	11.0	Publications
49	CALB2	calbindin 2	11.0	Publications
50	RARS	arginyl-tRNA synthetase	11.0

Pathways related to thrombocytosis according to GeneDecks:

(show top 50)    (show all 100)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.3	CSF2, LIF, PF4, CSF3, CXCL12, IL3
2	Ras Pathway36	10.3	EPOR, CXCL12, PPBP, IL3, FLT3
3	Platelet activation, signaling and aggregation38	10.1	VWF, FGA, TBXA2R, PPBP, PF4
4	Molecular Mechanisms of Cancer36	10.0	LIF, JAK1, IL11, IL3, IL6, PPBP
5	NF-KappaB (p50-p65) Pathway36	9.9	IL1A, IL3, IL6, PPBP, THPO, CXCL12
6	IL-6 Pathway36	9.9	CSF3, PF4, IL4, IL3, IL11, CSF2
7	Extrinsic Prothrombin Activation Pathway36	9.9	F3, F10, FGA, F5, SERPINC1, THBD
8	Tuberculosis20	9.8	IFNA1, IFNA2, IL6, CEBPB, IL1A, JAK2
9	14-3-3 Induced Intracellular Signaling36	9.8	IL3, EPOR, THPO, PDGFRB, PPBP, FLT3
10	Rheumatoid arthritis20	9.7	IL6, IL1B, CSF2, CXCL12, VEGFA, IL11
11	Paxillin Interactions36	9.7	FLT3, CXCL12, KITLG, IL3, PPBP, THPO
12	NFAT Signaling and Lymphocyte Interactions36	9.7	IL1A, IL3, IL11, IL4, CXCL12
13	Nanog in Mammalian ESC Pluripotency36	9.7	PDGFRB, IL3, IL6, PPBP, FLT3, CXCL12
14	Cytokine Network36	9.7	IL4, IFNA2, IFNA1, IL6, IL3, IL1B
15	Intrinsic Prothrombin Activation Pathway36	9.6	THBD, F5, F2, F10, F8, FGA
16	Blood Coagulation Cascade36	9.6	THBD, F3, F5, FGA, F10, F8
17	JNK Pathway36	9.6	CXCL12, KITLG, EPOR, IL6, CEBPB, FLT3
18	DHA Signaling36	9.5	CXCL12, THPO, PDGFRB, IL1B, PPBP, KITLG
19	NF-KappaB Family Pathway36	9.5	THPO, IL1B, KITLG, IL1A, CXCL12, PPBP
20	TGF-Beta Pathway36	9.5	IL1B, IL11, KITLG, IL3, IL4, PPBP
21	SOCS Pathway36	9.5	IL1A, IL1B, JAK1, JAK2, IL3, IL11
22	Blood Coagulation Signaling Pathways37	9.4	GP1BA, SERPINF2, SERPINC1, VWF, F8, F5
23	Pancreatic Adenocarcinoma36	9.4	EPOR, CXCL12, THPO, PDGFRB, PPBP, IL6
24	eNOS Signaling36	9.4	PDGFRB, FLT3, EPOR, CXCL12, KITLG, THPO
25	Measles20	9.4	JAK1, IL1A, IL4, IL6, IFNA1, JAK2
26	MAPK Signaling36	9.4	IL1A, FLT3, EPOR, CXCL12, CEBPB, KITLG
27	ERK5 Signaling36	9.4	CXCL12, KITLG, LIF, IL3, IL6, PPBP
28	MIF Mediated Glucocorticoid Regulation36	9.4	IL4, CSF2, PF4, IL6, IL3, IL1B
29	MIF Regulation of Innate Immune Cells36	9.4	IL4, IL1B, IL11, CSF3, LIF, CSF2
30	all-trans-Retinoic Acid Signaling in Brain36	9.4	LIF, IL11, IL1A, IL1B, IL3, IL4
31	PEDF Induced Signaling36	9.4	CSF2, CSF3, CXCL12, PF4, IL6, IL4
32	MAPK Family Pathway36	9.4	CXCL12, THPO, PPBP, IL6, IL3, IL1B
33	Complement and coagulation cascades20	9.3	F3, VWF, SERPINC1, SERPINF2, FGA, F5
34	NFAT in Immune Response36	9.3	IL3, FLT3, IL6, EPOR, CXCL12, THPO
35	STAT3 Pathway36	9.2	CSF3R, CSF3, CXCL12, PF4, CSF2, IL6
36	Activation of PKA through GPCR36	9.2	PDGFRB, FLT3, THPO, CXCL12, EPOR, PPBP
37	Jak-STAT signaling pathway20	9.1	MPL, JAK1, JAK2, IL11, IL3, IL4
38	Pathways in cancer20	9.0	VEGFA, JAK1, MECOM, RUNX1, CSF3R, FLT3
39	Endothelin-1 Signaling Pathway36	9.0	FLT3, IL11, EPOR, CSF3, CXCL12, PDGFRB
40	Akt Signaling36	8.9	IL11, IL4, IL6, PF4, PDGFRB, THPO
41	Hematopoietic cell lineage20	8.9	IL1B, IL3, IL4, IL1A, IL11, FLT3
42	p70S6K Signaling36	8.8	F2, THPO, PDGFRB, PPBP, CXCL12, IL6
43	ERK Signaling36	8.7	KITLG, FLT3, IL1A, EPOR, IL11, IL1B
44	PAK Pathway36	8.7	IL1A, IL1B, IL3, IL4, IL6, PPBP
45	Rho Family GTPases36	8.6	CSF3, CSF2, CXCL12, THPO, PF4, PPBP
46	Tec Kinases Signaling36	8.5	THPO, PDGFRB, IL4, JAK1, CXCL12, CSF3R
47	Antioxidant Action of Vitamin-C36	8.5	KITLG, IL3, CSF3R, CSF3, CSF2, CXCL12
48	p38 Signaling36	8.4	CSF3, LIF, IL6, IL4, KITLG, CSF2
49	JAK-STAT Pathway36	8.2	IL1B, IL1A, IL11, EPOR, JAK2, JAK1
50	Cytokine-cytokine receptor interaction20	7.0	IL3, IL4, IL6, IFNA1, IFNA2, VEGFA

Compounds related to thrombocytosis according to GeneDecks:

(show top 50)    (show all 430)

id	Compound	Score	Top Affiliating Genes
1	anagrelide32 9 9	12.3	EPO, CSF2, THPO, PF4, IFNA2, IFNA1
2	pixy32132	10.2	KITLG, FLT3, IL11, IL3, EPO, CSF3
3	hyaluronic acid32 18	11.1	PPBP, CALB2, F2, IL11, THBD, ADAMTSL1
4	pge232	10.0	IL1A, AR, LIF, HP, TBXA2R, PPBP
5	polyethylene glycol32	10.0	THBD, PF4, HP, F10, F8, IFNA2
6	filgrastim32 9 9	11.9	EPO, CSF3R, CSF3, CSF2, THPO, IFNA2
7	ristocetin32	9.9	PPBP, F2, F8, GP1BA, SERPINF2, SERPINC1
8	thromboxane32 18	10.9	THPO, THBD, TYMP, PF4, NFE2, PPBP
9	txb232	9.8	ADAMTSL1, THBD, PF4, PPBP, TBXA2R, F3
10	hydroxyurea32 9 9	11.8	CSF3, CSF2, THPO, PF4, PPBP, F2
11	argatroban32 9 9	11.8	SERPINC1, SELP, FGA, F5, F3, THBD
12	bivalirudin32 9 9	11.8	THBD, F10, F2, F3, F5, FGA
13	ticlopidine32 9 9	11.8	CSF2, PF4, PPBP, TBXA2R, HMGCR, F3
14	clopidogrel32 34 9 18 9	13.7	PPBP, TBXA2R, HMGCR, F10, CD40LG, SERPINC1
15	gp 13032	9.7	LIF, CEBPB, MPL, JAK1, EPOR, EPO
16	hirudin32	9.6	SERPINC1, SERPINF2, FGA, GP1BA, ADAMTSL1, THPO
17	rituximab32 34 9 9	12.5	CD40LG, CD79A, F8, CRP, CXCL12, CSF2
18	ascorbic acid32 18	10.5	LIF, JAK2, EPO, TPO, F10, IFNA2
19	aprotinin32 9 9	11.5	THBD, PF4, PPBP, F10, F2, F5
20	polysulfone32	9.4	VWF, SELP, FGA, EPO, PF4, CRP
21	carboplatin32 34 9 9	12.2	IL3, IL1A, IL11, MTHFR, LIF, VEGFA
22	endotoxin32	9.1	SERPINF2, LIF, CEBPB, JAK2, CSF3R, CSF3
23	aspartate32	8.8	ADAMTSL1, THBD, TPO, HP, F10, F2
24	rapamycin32 42	9.6	NF1, HMGCR, AR, JAK2, VEGFA, KITLG
25	rantes32	8.5	CD40LG, CEBPB, LIF, SELP, KITLG, IL11
26	mycophenolate mofetil32 9 9	10.3	EPO, CSF3, THBD, ALB, F5, IFNA1
27	calcitriol32 42 9 18 9	12.1	AR, LIF, RARS, KITLG, IL11, IL3
28	cyclosporin a32 42	9.0	THBD, VWF, KITLG, SELP, LIF, MTHFR
29	imatinib32 34 9 9	10.8	RUNX1, CSF3R, CSF3, CXCL12, THPO, PDGFRB
30	genistein32 9 18 9	10.6	IL1B, IL1A, AR, CD40LG, JAK2, CEBPB
31	nitric oxide32 9 18 9	10.6	CALB2, KITLG, VWF, SELP, F5, F8
32	indomethacin32 9 9	9.5	TBXA2R, CEBPB, JAK2, ALB, IFNA2, GP1BA
33	warfarin32 34 9 18 9	11.5	SERPINC1, SELP, VWF, MTHFR, CD79A, FGA
34	estrogen32	7.4	SERPINC1, VWF, SERPINA7, PDGFRB, NF1, HP
35	steroid32	7.3	IFNA2, IL11, AR, CD79A, JAK2, LIF
36	thymidine32 18	8.2	EPO, ADAMTSL1, CSF3R, CSF3, CSF2, CXCL12
37	actinomycin d32	7.2	IL6, KITLG, IL4, IL3, IL1B, IL1A
38	adp32 18	8.2	PF4, PPBP, TBXA2R, F10, F2, F3
39	heparin32 9 18 9	10.0	F2, F3, F8, IL3, IL11, FGA
40	cysteine32	6.8	CSF2, THBD, TYMP, PDGFRB, PF4, NF1
41	arginine32	6.8	CPB2, THBD, PF4, NF1, TPO, HMGCR
42	testosterone32 9 18 9	9.8	EPO, PDGFRB, SERPINF2, SERPINA7, SERPINC1, KITLG
43	creatinine32	6.7	EPO, CPB2, THPO, THBD, TYMP, PF4
44	lactate32	6.7	CSF2, THPO, THBD, PF4, CRP, PPBP
45	aspirin32 34 18	8.7	PPBP, MPL, CEBPB, MTHFR, SERPINA7, SERPINC1
46	fibrinogen32	6.7	PF4, CRP, PPBP, TBXA2R, TPO, HP
47	cycloheximide32	6.4	ADAMTSL1, CSF3R, CSF3, IL3, IL1B, IL1A
48	vegf32	5.4	EPOR, EPO, ADAMTSL1, RUNX1, CSF3R, CSF3
49	tyrosine32	4.9	CSF3R, CSF3, CSF2, CXCL12, THPO, THBD
50	serine32	4.8	JAK1, MPL, CEBPB, MTHFR, LIF, SERPINF2

Cellular components related to thrombocytosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	8.7	IL4, FGA, CD40LG, CD79A, SELP, VWF
2	platelet alpha granule lumen	GO:031093	7.8	PF4, PPBP, ALB, F5, F8, FGA
3	extracellular region	GO:005576	6.2	F2, ALB, F10, HP, PPBP, CRP
4	extracellular space	GO:005615	5.1	EPO, F5, F3, F2, ALB, HP

Biological processes related to thrombocytosis according to GeneDecks:

(show all 32)

id	Name	GO ID	Score	Top Affiliating Genes
1	blood circulation	GO:008015	10.5	NFE2, CXCL12, EPO
2	negative regulation of fibrinolysis	GO:051918	10.4	CPB2, THBD, F2, SERPINF2
3	fibrinolysis	GO:042730	10.4	CPB2, F2, GP1BA, SERPINF2
4	positive regulation of DNA replication	GO:045740	10.4	KITLG, IL3, CSF2, EPO
5	blood coagulation, intrinsic pathway	GO:007597	10.2	F10, F2, F8, GP1BA, VWF
6	acute-phase response	GO:006953	10.2	CRP, F2, F8, IL6, CEBPB, SERPINF2
7	positive regulation of MAPK cascade	GO:043410	10.1	IL6, IL11, AR, FLT3, LIF
8	response to lipopolysaccharide	GO:032496	10.1	EPO, THPO, THBD, TBXA2R, F3, IL1A
9	embryonic hemopoiesis	GO:035162	10.1	RUNX1, TPO, IL3, KITLG
10	cytokine-mediated signaling pathway	GO:019221	10.0	CSF3, PF4, IFNA2, IL6, IL1B, IL1A
11	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.9	EPO, CSF2, IL4, IL3, JAK2
12	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.9	PDGFRB, F2, FLT3, JAK2, SELP
13	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.9	IL6, IL3, IL11, JAK2, LIF, VEGFA
14	dendritic cell differentiation	GO:097028	9.9	CSF2, IL4, FLT3
15	aging	GO:007568	9.9	EPO, HMGCR, F3, IL1B, SERPINA7
16	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.8	VEGFA, LIF, IL11, IL6
17	positive regulation of cell division	GO:051781	9.7	PPBP, IL1B, IL1A, VEGFA
18	inflammatory response	GO:006954	9.7	CRP, TBXA2R, IFNA2, IL6, IL1B, IL1A
19	positive regulation of angiogenesis	GO:045766	9.5	RUNX1, TBXA2R, F3, IL1B, IL1A, VEGFA
20	positive regulation of MAP kinase activity	GO:043406	9.4	PDGFRB, FLT3, VEGFA, KITLG
21	immune response	GO:006955	9.4	CSF3, CSF2, CXCL12, PF4, PPBP, IL4
22	positive regulation of endothelial cell proliferation	GO:001938	9.4	VEGFA, F3, NF1, CXCL12
23	response to hypoxia	GO:001666	9.3	CXCL12, NF1, CRP, IL1B, IL1A, VEGFA
24	peptidyl-tyrosine phosphorylation	GO:018108	9.3	PDGFRB, FLT3, JAK2, JAK1
25	B cell differentiation	GO:030183	9.3	IL4, IL11, FLT3, CD40LG, CD79A
26	positive regulation of cell migration	GO:030335	9.1	VEGFA, JAK2, F3, F10, PDGFRB
27	positive regulation of cell proliferation	GO:008284	8.7	F2, PDGFRB, THPO, CSF2, CSF3, EPO
28	platelet degranulation	GO:002576	8.4	PF4, PPBP, ALB, F5, F8, FGA
29	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.4	RUNX1, IL6, IL4, IL1B, IL1A, IL11
30	negative regulation of apoptotic process	GO:043066	8.1	EPO, CSF2, CXCL12, PF4, ALB, IL6
31	platelet activation	GO:030168	7.5	THPO, CD40LG, MPL, VEGFA, SERPINF2, SELP
32	blood coagulation	GO:007596	7.2	CPB2, THPO, THBD, PF4, FGA, CD177

Molecular functions related to thrombocytosis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	eukaryotic cell surface binding	GO:043499	10.3	SELP, SERPINF2, FGA, EPO
2	protease binding	GO:002020	10.1	SERPINC1, SERPINF2, F3
3	platelet-derived growth factor receptor binding	GO:005161	9.2	TYMP, PDGFRB, VEGFA
4	receptor binding	GO:005102	8.9	CXCL12, PDGFRB, F2, FGA, AR, JAK2
5	protein homodimerization activity	GO:042803	8.8	CRP, HMGCR, MECOM, FLT3, CEBPB, VEGFA
6	growth factor activity	GO:008083	8.2	CSF3, CSF2, KITLG, VEGFA, LIF, IL11
7	cytokine activity	GO:005125	8.2	CSF3, VEGFA, LIF, CD40LG, IL11, IL1A
8	protein binding	GO:005515	3.5	TBXA2R, F10, ALB, F2, F3, F5