MCID: THR004
MIFTS: 61

Thrombocytosis malady

Cancer diseases, Blood diseases categories
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Summaries for Thrombocytosis

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Disease Ontology:8 A myeloma and blood platelet disease that is characterized by the presence of high platelet counts in the blood.

MalaCards based summary: Thrombocytosis, also known as platelet count above reference range, is related to thrombocythemia 1 and myelofibrosis. An important gene associated with Thrombocytosis is THPO (thrombopoietin), and among its related pathways are Paxillin-dependent events mediated by a4b1 and Development EPO induced Jak STAT pathway. The drugs chlorambucil and uracil mustard and the compounds megapoietin and pp 100 have been mentioned in the context of this disorder. Affiliated tissues include lung, myeloid and bone marrow, and related mouse phenotypes are cellular and immune system.

Wikipedia:65 Thrombocytosis (or thrombocythemia) is the presence of high platelet counts in the blood, and can be... more...

Aliases & Classifications for Thrombocytosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt
See all sources

Thrombocytosis, Aliases & Descriptions:

Name: Thrombocytosis 8 10 44 62
Platelet Count Above Reference Range 8 62
 
Thrombocythaemia 8 62
Thrombocythemia 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


External Ids:

Disease Ontology8 DOID:2228
MeSH34 D013922
NCIt39 C35530

Related Diseases for Thrombocytosis

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Diseases related to Thrombocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 268)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocythemia 131.0THPO
2myelofibrosis31.0JAK2, THPO
3purpura30.8THPO
4refractory anemia30.8THPO, MPL, EPOR, JAK2
5myeloid leukemia30.7THPO, MPL, JAK2
6megakaryocytic leukemia30.6EPOR, THPO
7splenomegaly30.4THPO, MPL, JAK2
8thromboembolism30.4FGA, SERPINF2
9hemorrhagic thrombocythemia30.4CD177, JAK2, MPL, THPO
10polycythemia30.4THPO, MPL, EPOR, JAK2, CD177
11polycythemia vera30.4THPO, MPL, EPOR, JAK2, CD177
12autoimmune thrombocytopenic purpura30.3MPL, THPO
13erythrocytosis30.3CD177, JAK2, EPOR, MPL
14pancytopenia30.3THPO, MPL
15deficiency anemia30.2THPO, MPL, EPOR, JAK2, IL6
16myocardial infarction30.2GP1BA, SERPINF2, FGA
17chronic myeloid leukemia30.1THPO, MPL, EPOR, JAK2, CD177
18venous thrombosis30.0FGA, JAK2, SERPINF2
19aplastic anemia30.0THPO, GP1BA, MPL
20hepatoblastoma30.0EPOR, MPL, THPO
21pulmonary embolism30.0FGA, SERPINF2
22thrombocytopenia29.9THPO, GP1BA, MPL, IL6, FGA
23myelodysplastic syndromes29.8THPO, GP1BA, MPL, EPOR, JAK2, CD177
24myeloma29.7IL6, JAK2, EPOR
25sickle cell disease29.7FGA, EPOR
26vascular disease29.7SERPINF2, JAK2, IL6
27thrombophilia29.7FGA, SERPINF2
28ischemia29.6FGA, JAK2, EPOR
29systemic lupus erythematosus29.5MPL, IL6, FGA
30nephrotic syndrome29.3FGA, SERPINF2
31diabetes mellitus29.3GP1BA, IL6, FGA
32leukemia29.3THPO, MPL, SERPINF2, EPOR, JAK2, IL6
33atherosclerosis29.3FGA, IL6, SERPINF2
34acute leukemia29.2THPO, MPL, EPOR, JAK2, FGA
35essential thrombocythemia10.5
36iron deficiency anemia10.4
37ovarian cancer10.4
38lung cancer10.4
39renal cell carcinoma10.4
40congenital amegakaryocytic thrombocytopenia10.4THPO, MPL
41thrombocytopenia due to platelet alloimmunization10.3THPO, MPL
42severe congenital neutropenia10.3THPO, JAK2
43bone marrow cancer10.3MPL, JAK2
44pneumonia10.3
45pdgfrb-associated chronic eosinophilic leukemia10.3JAK2, MPL
46acquired polycythemia10.3EPOR, JAK2
47primary polycythemia10.3JAK2, EPOR
48blood platelet disease10.3GP1BA, THPO
49arthritis10.2
50coronary thrombosis10.2

Graphical network of the top 20 diseases related to Thrombocytosis:



Diseases related to thrombocytosis

Symptoms for Thrombocytosis

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Drugs & Therapeutics for Thrombocytosis

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Drug clinical trials:

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Search NIH Clinical Center for Thrombocytosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Thrombocytosis

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Anatomical Context for Thrombocytosis

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MalaCards organs/tissues related to Thrombocytosis:

32
Lung, Myeloid, Bone marrow, Bone, Heart, Liver, Breast, Neutrophil, Whole blood, Spleen, Thyroid, Skin, Endothelial, Lymph node, Colon, Ovary, Placenta, Testes, Tongue

Animal Models for Thrombocytosis or affiliated genes

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MGI Mouse Phenotypes related to Thrombocytosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.2IL6, JAK2, EPOR, MPL, GP1BA
2MP:00053877.3THPO, MPL, EPOR, JAK2, IL6, FGA
3MP:00053977.1FGA, THPO, GP1BA, MPL, EPOR, JAK2
4MP:00053766.7GP1BA, MPL, SERPINF2, EPOR, JAK2, IL6

Publications for Thrombocytosis

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Articles related to Thrombocytosis:

(show top 50)    (show all 589)
idTitleAuthorsYear
1
Reactive thrombocytosis leading to acute myocardial infarction. (24772734)
2013
2
Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer. (23080345)
2013
3
Impressive thrombocytosis evolving in a patient with a BCR-ABL positive CML in major molecular response during dasatinib treatment unmasks an additional JAK2V617F. (24007855)
2013
4
Plateletpheresis for postsplenectomy rebound thrombocytosis in a patient with chronic immune thrombocytopenic purpura on romiplostim. (23450778)
2013
5
The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer. (24285160)
2013
6
Iron deficiency generates secondary thrombocytosis and platelet activation in IBD: the randomized, controlled thromboVIT trial. (23644823)
2013
7
EXEL-8232, a small-molecule JAK2 inhibitor, effectively treats thrombocytosis and extramedullary hematopoiesis in a murine model of myeloproliferative neoplasm induced by MPLW515L. (22005786)
2012
8
Chronic myeloid leukemia with extreme thrombocytosis. (22479272)
2012
9
Absence of JAK2V617F mutation in patients with beta-thalassemia major and thrombocytosis due to splenectomy. (22203487)
2012
10
Impact of pretreatment thrombocytosis on blood-borne metastasis and prognosis of gastric cancer. (22592098)
2012
11
Teaching NeuroImages: disappearing intraluminal thrombus of the carotid artery in reactive thrombocytosis. (21502592)
2011
12
Thrombocytosis in children. (22075805)
2011
13
The impact of pretreatment thrombocytosis and persistent thrombocytosis after adjuvant chemotherapy in patients with advanced epithelial ovarian cancer. (21531448)
2011
14
Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis. (19903679)
2010
15
Cholestatic hepatitis and thrombocytosis in a secondary syphilis patient. (21060758)
2010
16
The role of the Platelet Function Analyzer (PFA)-100 and platelet aggregometry in the differentiation of essential thrombocythemia from reactive thrombocytosis. (19664802)
2010
17
Geminin deletion from hematopoietic cells causes anemia and thrombocytosis in mice. (21041951)
2010
18
A case of acute promyelocytic leukemia showing transient thrombocytosis caused by increased interleukin-6 and thrombopoietin after treatment with all-trans retinoic acid and chemotherapy. (19461187)
2009
19
The role of thrombocytosis in prognostic evaluation of epithelial ovarian tumors. (18470520)
2009
20
Isolated thrombocytosis as first sign of chronic myeloid leukemia with e6a2 BCR/ABL fusion transcript, JAK2 negativity and complete response to imatinib. (17688946)
2008
21
Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythemia. (18587010)
2008
22
Philadelphia chromosome-positive chronic myeloid leukemia with p190(BCR-ABL) rearrangement, overexpression of the EVI1 gene, and extreme thrombocytosis: a case report. (18262061)
2008
23
Aortic thrombus due to essential thrombocytosis: strategies for medical and surgical management. (18513483)
2008
24
Pulmonary hypertension in patients with essential thrombocythemia and reactive thrombocytosis. (17852711)
2007
25
Thrombocytosis induced in mice after subacute and subchronic V2O5 inhalation. (16716040)
2006
26
Extreme thrombocytosis: what are the etiologies? (16444439)
2006
27
Patterns of thrombocytosis and thrombocytopenia in hospitalized neonates. (15578031)
2005
28
Primary and secondary thrombocytosis in childhood. (15813844)
2005
29
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. (16293924)
2005
30
The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis. (13679323)
2003
31
Essential thrombocytosis causing a massive myocardial infarction. (12826291)
2003
32
Philadelphia chromosome and/or bcr-abl mRNA-positive primary thrombocytosis: morphometric evidence for the transition from essential thrombocythaemia to chronic myeloid leukaemia type of myeloproliferation. (12493025)
2003
33
Reactive thrombocytosis alone does not affect the patency of microvascular anastomosis in the splenectomy rat. (12172143)
2002
34
Bloodstream thrombopoietin in rheumatoid arthritis with thrombocytosis. (12447626)
2002
35
Thrombocytosis in children with iron deficiency anemia: series of 42 children. (12368707)
2002
36
Thrombocytosis is associated with a significant increase in the cancer specific death rate after radical nephrectomy. (12352397)
2002
37
Pseudohyperkalemia occurring in a patient with chronic renal failure and polycythemia vera without severe leukocytosis or thrombocytosis. (12508968)
2002
38
Familial thrombocytosis as a recessive, possibly X-linked trait in an Arab family. (11260062)
2001
39
Extreme self-limited thrombocytosis in a young patient. (11669311)
2001
40
Preoperative thrombocytosis is an independent prognostic factor in stage III and IV endometrial cancer. (11268488)
2000
41
Rapid reduction of platelet numbers in thrombocytosis. (11111819)
2000
42
Leucocytosis, thrombocytosis, and plasma osmolality during rest and exercise: an hypothesis. (10424721)
1999
43
The observation of reactive thrombocytosis in New Zealand white rabbits in response to experimental Pasteurella multocida infection. (10389591)
1999
44
Prolonged extreme thrombocytosis associated with neurofibromatosis type 1. (9042140)
1997
45
Elevated plasma thrombopoietic activity in patients with metastatic cancer-related thrombocytosis. (7539977)
1995
46
Establishment and characterization of a new human mesothelioma cell line (T-85) from malignant peritoneal mesothelioma with remarkable thrombocytosis. (8581142)
1995
47
High IL-6 levels in ascitic fluid correlate with reactive thrombocytosis in patients with epithelial ovarian cancer. (8485049)
1993
48
Serum interleukin-6 levels in patients with thrombocytosis. (1490150)
1992
49
Thrombocytosis and hyposplenism in an infant with fetal hydantoin syndrome. (1550265)
1992
50
Interleukin-1 beta (IL-1 beta) induces thrombocytosis in mice: possible implication of IL-6. (2265245)
1990

Variations for Thrombocytosis

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Expression for genes affiliated with Thrombocytosis

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Expression patterns in normal tissues for genes affiliated with Thrombocytosis

Search GEO for disease gene expression data for Thrombocytosis.

Pathways for genes affiliated with Thrombocytosis

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Pathways related to Thrombocytosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b737
a4b1 and a4b7 Integrin signaling37
9.6JAK2, EPOR
2
Show member pathways
EPO Receptor Signaling37
EPO signaling pathway37
9.6EPOR, JAK2
3
Show member pathways
9.5JAK2, IL6
49.5IL6, JAK2
59.5JAK2, IL6
6
Show member pathways
IL27-mediated signaling events37
9.5JAK2, IL6
7
Show member pathways
9.5IL6, JAK2
8
Show member pathways
9.5IL6, JAK2
99.4IL6, GP1BA
10
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.4MPL, THPO, JAK2
11
Show member pathways
9.2IL6, JAK2, THPO
12
Show member pathways
9.2IL6, THPO, EPOR
13
Show member pathways
9.2THPO, EPOR, IL6
149.1EPOR, JAK2, IL6
15
Show member pathways
9.1IL6, JAK2, EPOR
16
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.0FGA, SERPINF2
17
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.9JAK2, MPL, IL6, THPO
18
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
8.8EPOR, JAK2, FGA
19
Show member pathways
8.8IL6, JAK2, EPOR, THPO
20
Show member pathways
8.8IL6, THPO, EPOR, JAK2
21
Show member pathways
8.8JAK2, IL6, THPO, EPOR
22
Show member pathways
8.7MPL, EPOR, JAK2, IL6
23
Show member pathways
Type III interferon signaling37
8.7EPOR, JAK2, IL6, MPL
248.7THPO, GP1BA, EPOR, IL6
25
Show member pathways
8.5SERPINF2, FGA, GP1BA
26
Show member pathways
8.5MPL, THPO, FGA, GP1BA
27
Show member pathways
8.4JAK2, THPO, MPL, EPOR, IL6
28
Show member pathways
7.1THPO, CD177, JAK2, SERPINF2, MPL, GP1BA

Compounds for genes affiliated with Thrombocytosis

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Compounds related to Thrombocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1megapoietin4410.2MPL, THPO
2pp 1004410.0EPOR, JAK2
3pixy321449.9IL6, THPO
4filgrastim44 1110.9THPO, IL6
5anagrelide44 1110.8JAK2, THPO, MPL
6phorbol 12,13-dibutyrate449.8JAK2, THPO
7polyethylene449.7FGA, THPO
8methylcellulose449.6THPO, EPOR, IL6
9ristocetin449.6GP1BA, SERPINF2
10gm-csf44 2810.5IL6, THPO
11fibrinopeptide a449.4FGA, SERPINF2
12agar449.4EPOR, MPL, THPO, JAK2
13sb 20358044 6110.3THPO, JAK2, IL6
14desmopressin44 61 28 1112.3SERPINF2, GP1BA
156-ketoprostaglandin f1alpha449.3FGA, SERPINF2
16asparagine449.2SERPINF2, EPOR, GP1BA
17ptca449.2SERPINF2, FGA
18cuprophan449.2SERPINF2, FGA
19latex449.2FGA, THPO, GP1BA
20ly294002449.2EPOR, IL6, JAK2, THPO
21actinomycin d449.1JAK2, IL6, EPOR, THPO
22lysine449.1MPL, SERPINF2, JAK2, THPO
23prostacyclin449.1THPO, GP1BA, FGA
24indomethacin44 28 61 1112.1GP1BA, JAK2, IL6, THPO
25oligonucleotide449.0EPOR, THPO, GP1BA, JAK2
26nitric oxide44 24 1111.0EPOR, JAK2, THPO, IL6
27gp 130448.9IL6, JAK2, EPOR, MPL, THPO
28phosphatidylinositol448.8THPO, GP1BA, MPL, EPOR, JAK2
29thromboxane44 249.8SERPINF2, FGA, MPL, THPO
30phenylalanine448.7EPOR, GP1BA, JAK2, FGA
31oxygen44 249.7EPOR, JAK2, SERPINF2, THPO
32hirudin448.6THPO, FGA, GP1BA, SERPINF2
33lactate448.6IL6, GP1BA, THPO, FGA
34glucose448.6THPO, JAK2, GP1BA, IL6, EPOR
35endotoxin448.5FGA, SERPINF2, IL6, JAK2
36heparin44 28 24 1111.5GP1BA, THPO, FGA, SERPINF2
37aspirin44 50 28 2411.5THPO, GP1BA, MPL, JAK2, FGA
38estrogen448.5JAK2, EPOR, THPO, IL6
39aprotinin44 119.4SERPINF2, FGA, IL6, GP1BA
40cholesterol44 28 24 1111.4FGA, IL6, JAK2, SERPINF2
41thymidine44 249.4FGA, IL6, JAK2, EPOR, THPO
42vegf448.2JAK2, IL6, THPO, SERPINF2, EPOR, MPL
43fibrinogen448.1GP1BA, IL6, FGA, SERPINF2, THPO
44lipid448.0FGA, IL6, SERPINF2, JAK2, EPOR
45adp44 28 249.9GP1BA, FGA, JAK2, SERPINF2, THPO, MPL
46alanine447.7THPO, IL6, JAK2, EPOR, SERPINF2, MPL
47epinephrine44 24 119.7SERPINF2, GP1BA, THPO, JAK2, IL6, FGA
48serine447.7FGA, EPOR, SERPINF2, MPL, GP1BA, JAK2
49calcium44 50 24 1110.7EPOR, JAK2, SERPINF2, GP1BA, THPO, FGA
50tyrosine447.1THPO, GP1BA, MPL, EPOR, FGA, CD177

GO Terms for genes affiliated with Thrombocytosis

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Cellular components related to Thrombocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.0FGA, SERPINF2
2fibrinogen complexGO:0055778.9FGA, SERPINF2
3extracellular spaceGO:0056157.9FGA, IL6, SERPINF2, THPO

Biological processes related to Thrombocytosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein import into nucleus, translocationGO:0331609.8IL6, JAK2
2positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.8JAK2, IL6
3positive regulation of nitric oxide biosynthetic processGO:0454299.7IL6, JAK2
4response to antibioticGO:0466779.7JAK2, IL6
5positive regulation of cell differentiationGO:0455979.6JAK2, SERPINF2
6fibrinolysisGO:0427309.6SERPINF2, GP1BA
7acute-phase responseGO:0069539.4IL6, SERPINF2
8positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4IL6, JAK2
9positive regulation of smooth muscle cell proliferationGO:0486619.4SERPINF2, IL6
10positive regulation of protein kinase B signalingGO:0518979.3IL6, THPO
11positive regulation of ERK1 and ERK2 cascadeGO:0703749.3THPO, SERPINF2, IL6
12response to calcium ionGO:0515929.1FGA, IL6
13platelet degranulationGO:0025769.0FGA, SERPINF2
14platelet activationGO:0301687.6THPO, GP1BA, MPL, SERPINF2, IL6, FGA
15blood coagulationGO:0075967.4FGA, THPO, GP1BA, MPL, SERPINF2, JAK2

Products for genes affiliated with Thrombocytosis

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Sources for Thrombocytosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet