MCID: THR004
MIFTS: 63

Thrombocytosis malady

Blood diseases category

Summaries for Thrombocytosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A myeloma and blood platelet disorder that is characterized by the presence of high platelet counts in the blood.

MalaCards: Thrombocytosis, also known as platelet count above reference range, is related to leukemia and iron deficiency anemia. An important gene associated with Thrombocytosis is THPO (thrombopoietin), and among its related pathways are Signaling events mediated by Stem cell factor receptor (c-Kit) and Development EPO-induced Jak-STAT pathway. The drugs chlorambucil and uracil mustard and the compounds pge2 and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include myeloid, lung and bone marrow, and related mouse phenotypes are integument and liver/biliary system.

Wikipedia:63 Thrombocytosis (or thrombocythemia) is the presence of high platelet counts in the blood, and can be... more...

Aliases & Classifications for Thrombocytosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

thrombocytosis 8 10 44 60
platelet count above reference range 8
thrombocythaemia 8
thrombocythemia 8


External Ids:

Disease Ontology8 DOID:2228
MeSH34 D013922
NCIt39 C35530

Related Diseases for Thrombocytosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Thrombocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 306)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.7EPO, CD177, NFE2, LIF, MPL, JAK2
2iron deficiency anemia30.5EPO, THPO
3polycythemia30.5THPO, PPBP, JAK2, MPL, NFE2, CD177
4polycythemia vera30.5PF4, IL3, THPO, SELP, EPOR, EPO
5deficiency anemia30.5CRP, MPL, LIF, NFE2, EPO, EPOR
6ovarian cancer30.5JAK2, LIF, FGA, IL3, IL11
7acute leukemia30.5JAK2, MPL, EPO, EPOR, FGA, IL3
8thrombocytopenia30.5MPL, NFE2, EPO, PF4, FGA, IL3
9myocardial infarction30.5SERPINF2, SELP, GP1BA, IL11, FGA, PF4
10myelofibrosis30.4JAK2, EPO, THPO
11myeloid leukemia30.4JAK2, MPL, LIF, IL3, IL11, THPO
12pneumonia30.3CRP, FGA, IL11, IL6
13arthritis30.3IL6, LIF, CRP
14chronic myeloid leukemia30.3CEBPB, SELP, THPO, IL11, PPBP, JAK2
15hypercalcemia30.2LIF
16hemorrhagic thrombocythemia30.2CD177
17acute myocardial infarction30.2PPBP, CRP, PF4, FGA, SELP, SERPINF2
18rheumatoid arthritis30.2PPBP, JAK2, CRP, LIF, PF4, IL11
19sarcoma30.2THPO, JAK2
20megakaryocytic leukemia30.2IL11, IL3, PF4, EPOR, THPO
21colorectal cancer30.1PF4, SELP, CEBPB
22leukemoid reaction30.1IL3
23inflammatory bowel disease30.1SELP, IL6, IL11, CRP, JAK2
24purpura30.0THPO
25primary polycythemia30.0JAK2, EPO, EPOR
26pancreatitis30.0CRP, IL11, IL6, SELP
27hepatocellular carcinoma30.0IL6, EPOR, PPBP
28breast cancer30.0PPBP, JAK2, LIF, EPOR, IL11, GP1BA
29portal vein thrombosis29.9THPO
30bronchiolitis29.9IL11
31pancreatic cancer29.9CEBPB
32hypertension29.9CRP, PPBP
33kawasaki disease29.9CRP
34antiphospholipid syndrome29.9SELP, PF4
35acquired thrombocytopenia29.9IL11, THPO
36ischemia29.9JAK2, EPOR, PF4, FGA, SELP
37tuberculosis29.9CEBPB, IL11, PF4, CRP
38vasculitis29.9PPBP, CRP, FGA, SELP
39hyperhomocysteinemia29.7CRP, SELP
40skin disease29.7IL6
41stroke, ischemic29.7PPBP, PF4, FGA, SELP
42dilated cardiomyopathy29.7FGA
43aplastic anemia29.7MPL, EPO, IL3, IL11, GP1BA, THPO
44diabetes mellitus29.7CRP, PF4, FGA, IL6, GP1BA, SELP
45atherosclerosis29.7PPBP, CRP, LIF, PF4, FGA, IL6
46multiple myeloma29.7IL6
47glomerulonephritis29.7EPOR
48hepatitis c29.7THPO
49chronic myeloproliferative disease29.7JAK2, MPL, THPO
50nephrotic syndrome29.7SERPINF2, FGA, PPBP

Graphical network of the top 20 diseases related to Thrombocytosis:



Diseases related to thrombocytosis

Clinical Features for Thrombocytosis

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Drugs & Therapeutics for Thrombocytosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Thrombocytosis

Drug clinical trials:

Search ClinicalTrials for Thrombocytosis

Search NIH Clinical Center for Thrombocytosis

Search CenterWatch for Thrombocytosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Thrombocytosis

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Anatomical Context for Thrombocytosis

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32MalaCards
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MalaCards organs/tissues related to Thrombocytosis:

32
Myeloid, Lung, Bone marrow, Bone, Liver, Breast, Heart, Endothelial, Skin, Spleen, Whole blood, Thyroid, Colon, Testes, Lymph node, Tongue, Ovary, Placenta

Animal Models for Thrombocytosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thrombocytosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.3LIF, NFE2, FGA, IL6, CEBPB
2MP:000537010.2LIF, EPO, EPOR, FGA, IL6, SELP
3MP:000539010.2LIF, NFE2, FGA, IL6, CEBPB, JAK2
4MP:000538710.0JAK2, CRP, MPL, LIF, NFE2, EPOR
5MP:000538410.0JAK2, MPL, LIF, EPO, EPOR, IL3
6MP:000539710.0CEBPB, JAK2, MPL, LIF, NFE2, EPO
7MP:000537610.0EPOR, EPO, LIF, MPL, CRP, JAK2
8MP:00107689.8NFE2, LIF, MPL, JAK2, EPO, EPOR
9MP:00053859.8CRP, LIF, NFE2, EPO, EPOR, FGA

Publications for Thrombocytosis

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50PubMed
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Articles related to Thrombocytosis:

(show top 50)    (show all 573)
idTitleAuthorsYear
1
Iron deficiency generates secondary thrombocytosis and platelet activation in IBD: the randomized, controlled thromboVIT trial. (23644823)
2013
2
Thrombocytosis has a negative prognostic value in lung cancer. (23564823)
2013
3
Cyclical thrombocytosis, acquired von Willebrand syndrome and aggressive non-melanoma skin cancers are common in patients with Philadelphia-negative myeloproliferative neoplasms treated with hydroxyurea. (23879199)
2013
4
Paraneoplastic thrombocytosis in ovarian cancer. (22335738)
2012
5
Severe thrombocytosis as initial manifestation of Caffey disease in a 4 month old infant. (22213629)
2012
6
Refractory anemia with ring sideroblasts associated with marked thrombocytosis harboring cytogenetic abnormality dup(2)(p15p22) treated with decitabine. (22468921)
2012
7
Thrombocytosis in children. (22075805)
2011
8
Thrombocytosis as an overt sign of cow's milk allergic proctocolitis. (21353366)
2011
9
Thrombocytosis associated with enoxaparin: A very rare cause in newborns. (20367573)
2010
10
You're the flight surgeon. Thrombocytosis. (20597253)
2010
11
What is the significance of thrombocytosis in patients with trauma? (19430238)
2009
12
Characterization of 35 new cases with four different MPLW515 mutations and essential thrombocytosis or primary myelofibrosis. (19029146)
2009
13
Long-term management of thrombocytosis in essential thrombocythaemia. (18629498)
2009
14
Genetic origins and clinical phenotype of familial and acquired erythrocytosis and thrombocytosis. (19006225)
2009
15
Aortic valve replacement in a young patient with essential thrombocytosis. (18234096)
2008
16
Coronary thrombosis in a patient with leukemic thrombocytosis: which was the best treatment? (18319708)
2008
17
Preoperative thrombocytosis predicts poor survival in patients with glioblastoma. (17504931)
2007
18
Thrombocytosis in myelodysplastic and myelodysplastic/myeloproliferative syndromes. (18067013)
2007
19
Thrombocytosis in cats: a retrospective study of 51 cases (2000-2005). (17387028)
2007
20
Thrombocytosis induced in mice after subacute and subchronic V2O5 inhalation. (16716040)
2006
21
Thrombocytosis accompanying urinary tract infection suggests obstruction or abscess. (16338518)
2006
22
Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation. (16741247)
2006
23
Occurrence of the JAK2 V617F mutation in the WHO provisional entity: myelodysplastic/myeloproliferative disease, unclassifiable-refractory anemia with ringed sideroblasts associated with marked thrombocytosis. (16670082)
2006
24
Ringed sideroblasts with thrombocytosis: an uncommon mixed myelodysplastic/myeloproliferative disease of older adults. (16197447)
2005
25
The prognostic significance of thrombocytosis in epithelial ovarian carcinoma. (14751160)
2004
26
Marked thrombocytosis in a child with advanced myelodysplastic syndrome. (15160971)
2004
27
Pathologic quiz case: a 29-year-old woman with thrombocytosis. Chronic myelogenous leukemia. (15043473)
2004
28
Anagrelide-induced bone marrow changes during therapy of chronic myeloproliferative disorders with thrombocytosis. an immunohistochemical and morphometric study of sequential trephine biopsies. (14555309)
2003
29
Cross-reactivity between erythropoietin and thrombopoietin at the level of Mpl does not account for the thrombocytosis seen in iron deficiency. (14608207)
2003
30
Thrombocytosis under ciprofloxacin and tazobactam/piperacillin. (12944250)
2003
31
Essential thrombocytosis and liver transplantation. (12555224)
2003
32
Reactive thrombocytosis alone does not affect the patency of microvascular anastomosis in the splenectomy rat. (12172143)
2002
33
Pseudohyperkalemia occurring in a patient with chronic renal failure and polycythemia vera without severe leukocytosis or thrombocytosis. (12508968)
2002
34
Extreme self-limited thrombocytosis in a young patient. (11669311)
2001
35
Endogenous megakaryocytic colony formation and thrombopoietin sensitivity of megakaryocytic progenitor cells are useful to distinguish between essential thrombocythemia and reactive thrombocytosis. (11454315)
2001
36
Increasing breathlessness, hyperkalaemia and thrombocytosis in a patient with chronic obstructive pulmonary disease. (11584622)
2001
37
Thrombopoietic cytokines in patients with iron deficiency anemia with or without thrombocytosis. (10940653)
2000
38
Isolated spleen agenesis: a rare cause of thrombocytosis mimicking essential thrombocythemia. (11064471)
2000
39
Thrombocytosis after prophylactic administration of enoxaparin: unexpected findings in a Polish prospective multicenter trial on the efficacy and safety of enoxaparin in the prevention of postoperative thromboembolism. (10392483)
1999
40
Paraneoplastic syndromes of leukocytosis, thrombocytosis, and hypercalcemia associated with squamous cell carcinoma. (10405479)
1999
41
Thrombocytosis in children at one medical center of southern Taiwan. (10910539)
1999
42
A case of pseudohyperkalaemia and thrombocytosis. (9777095)
1998
43
Elevated erythrocyte sedimentation rate and thrombocytosis as possible indicators of active disease in Langerhans' cell histiocytosis. (9825978)
1998
44
Prolonged extreme thrombocytosis associated with neurofibromatosis type 1. (9042140)
1997
45
Coronary vasospasm, multiple coronary thrombosis, unstable angina and essential thrombocytosis. (8282442)
1993
46
Establishment of large cell lung cancer cell lines secreting hematopoietic factors inducing leukocytosis and thrombocytosis. (1281895)
1992
47
Bilateral coronary thrombosis in the absence of inducible coronary spasm, thrombocytosis, coagulation abnormalities, or angiographic evidence of coronary artery disease: previously undescribed method of myocardial infarction. (3409313)
1988
48
Macrocytic anemia, thrombocytosis, and nonlobulated megakaryocytes (5q-syndrome): report of a case. (3949554)
1986
49
Platelet glyoxalases in thrombocytosis. (6463589)
1984
50
Leukemoid reaction, thrombocytosis and hypercalcemia associated with bladder cancer. (4757547)
1973

Genetic Variations for Thrombocytosis

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Expression for genes affiliated with Thrombocytosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thrombocytosis

Search GEO for disease gene expression data for Thrombocytosis.

Pathways for genes affiliated with Thrombocytosis

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 52R&D Systems, 51QIAGEN, 4Cell Signaling Technology, 29KEGG
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Pathways related to Thrombocytosis according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3JAK2, EPO, EPOR
2
Development EPO-induced Jak-STAT pathway
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10.3EPOR, EPO, JAK2
310.3EPOR, EPO, JAK2
4
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10.3SERPINF2, GP1BA, FGA
5
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10.3PPBP, MPL, THPO
610.3IL6, GP1BA, SELP
710.3CEBPB, IL6, JAK2
8
Mucin expression in CF via IL-6, IL-17 signaling pathways
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10.3CEBPB, IL6, JAK2
9
Hide members
10.3JAK2, MPL, IL6, THPO
1010.3JAK2, SELP, CEBPB
11
Hide members
10.3THPO, GP1BA, FGA, MPL
12
Development Thrombopoetin signaling via JAK-STAT pathway
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10.3JAK2, CRP, MPL, THPO
13
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10.3JAK2, EPO, EPOR, FGA
14
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10.3PPBP, IL3, IL6, THPO
1510.3JAK2, CRP, IL6, CEBPB
16
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10.3FGA, GP1BA, THPO, SELP, SERPINF2
1710.2JAK2, EPO, EPOR, IL3, IL6
18
Hide members
10.2PPBP, JAK2, IL3, IL6, THPO
19
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10.2JAK2, LIF, EPOR, IL11, IL6
20
Hide members
10.2THPO, IL6, IL3, EPOR, PPBP
21
Hide members
10.2PPBP, EPOR, IL3, IL6, THPO
22
Hide members
10.2PPBP, PF4, FGA, SELP, SERPINF2
23
Hide members
10.2PPBP, JAK2, EPOR, IL3, IL6, THPO
24
Hide members
10.2PPBP, LIF, EPOR, IL3, IL6, THPO
25
Hide members
10.2PPBP, CRP, EPOR, IL3, IL6, THPO
26
Hide members
10.2PPBP, JAK2, MPL, NFE2, CD177, PF4
2710.1EPO, EPOR, IL3, IL11, IL6, GP1BA
2810.1IL6, JAK2, MPL, LIF, EPO, EPOR
29
Hide members
10.1PPBP, JAK2, MPL, LIF, EPOR, IL3
30
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10.0IL6, IL11, IL3, PF4, EPOR, LIF
31
Hide members
10.0PPBP, CEBPB, THPO, IL6, IL11, IL3
32
Hide members
9.9PPBP, JAK2, LIF, EPOR, PF4, IL3

Compounds for genes affiliated with Thrombocytosis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Thrombocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
1pge24410.8PF4
2gm-csf44 2811.7THPO, LIF, IL11
3anagrelide44 1111.7JAK2, EPO, MPL, THPO, PF4
4il 114410.6LIF, EPO, IL6, IL11, IL3
5pixy3214410.6IL3, THPO, IL6, IL11, EPO
6filgrastim44 1111.6IL6, THPO, EPO, LIF, IL11, IL3
7endotoxin4410.6CEBPB, LIF, JAK2, FGA, IL11
8aprotinin44 1111.6SERPINF2, EPO, FGA, PF4, PPBP, SELP
9cuprophan4410.6SELP, EPO, SERPINF2, FGA, PF4, LIF
10ristocetin4410.6SELP, SERPINF2, GP1BA, PPBP, EPO
11methylcellulose4410.6THPO, IL6, IL11, IL3, EPO, LIF
12hirudin4410.6FGA, GP1BA, PF4, THPO, SELP, SERPINF2
13polysulfone4410.6SELP, PPBP, EPO, PF4, FGA, CRP
14ptca4410.5PF4, PPBP, FGA, SELP, SERPINF2
15thromboxane44 2411.5SERPINF2, SELP, THPO, FGA, NFE2, PPBP
16txb24410.5IL11, SELP, LIF, PPBP, SERPINF2, PF4
17desmopressin44 59 28 1113.5EPO, GP1BA, SELP, SERPINF2, PPBP
18iohexol4410.5SELP, FGA, PPBP, PF4
19thromboxane a244 2411.5LIF, FGA, THPO, SELP, PF4, PPBP
20latex4410.5PPBP, GP1BA, CRP, PF4, FGA, THPO
21glucose4410.5PF4, CEBPB, PPBP, LIF, IL11, GP1BA
22rantes4410.5IL11, IL6, PPBP, LIF, PF4, IL3
23gp 1304410.4MPL, CEBPB, THPO, IL6, JAK2, LIF
24prostacyclin4410.4FGA, PPBP, PF4, IL3, GP1BA, THPO
25hydroxyurea44 49 1112.4EPO, THPO, IL3, PF4, JAK2, PPBP
2611-dehydrothromboxane b24410.4PPBP, PF4, SELP, FGA
27heparin44 28 11 2413.4SELP, IL11, PPBP, THPO, GP1BA, LIF
28epinephrine44 11 2412.4SELP, PF4, FGA, IL11, JAK2, PPBP
29aspirin44 49 28 2413.4CEBPB, PPBP, JAK2, CRP, SELP, THPO
30ly2940024410.4EPO, IL3, THPO, IL6, CRP, JAK2
31agar4410.4JAK2, PF4, IL3, THPO, EPOR, MPL
32histamine44 28 2412.4PF4, PPBP, FGA, IL3, SELP, IL11
33actinomycin d4410.4EPOR, THPO, NFE2, LIF, IL3, JAK2
34indomethacin44 59 28 1113.4PF4, CEBPB, GP1BA
35thymidine44 2411.4FGA, LIF, JAK2, PPBP, PF4, IL3
36lactate4410.3SELP, CRP, EPO, PF4, FGA, LIF
37creatinine4410.3EPO, CRP, PPBP, SELP, THPO, IL6
38oxygen44 2411.3JAK2, PF4, IL11, SERPINF2, CEBPB, EPO
39dexamethasone44 49 28 1113.3IL3, PPBP, CEBPB, IL6, LIF
40alanine4410.3IL11, SERPINF2, EPOR, MPL, CRP, PF4
41fibrinogen4410.3PPBP, PF4, FGA, IL11, IL6, GP1BA
42phosphatidylinositol4410.3IL3, LIF, CEBPB, THPO, PPBP, GP1BA
43amifostine44 1111.3IL3, EPO, IL11, THPO
44vegf4410.3CRP, JAK2, PPBP, THPO, MPL, LIF
45cholesterol44 28 11 2413.2JAK2, PPBP, FGA, LIF, PF4, CRP
46tyrosine4410.1IL11, MPL, JAK2, PPBP, CEBPB, LIF
47cysteine4410.1SELP, PPBP, PF4, LIF, MPL, JAK2
48tgf beta14410.1PPBP, LIF, THPO, PF4, IL6, IL11
49nitric oxide44 11 2412.0PPBP, IL11, CEBPB, SELP, THPO, JAK2
506-ketoprostaglandin f1alpha4410.0PPBP, PF4, FGA, SERPINF2

GO Terms for genes affiliated with Thrombocytosis

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16Gene Ontology
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Cellular components related to Thrombocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:00557710.4SERPINF2, FGA
2platelet alpha granule lumenGO:03109310.0PPBP, PF4, FGA, SERPINF2
3extracellular spaceGO:0056159.9SERPINF2, PPBP, CRP, LIF, EPO, PF4
4extracellular regionGO:0055769.9EPOR, EPO, CRP, PPBP, PF4, FGA

Biological processes related to Thrombocytosis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.6IL3, EPO, JAK2
2negative regulation of hormone secretionGO:04688810.6LIF, IL11, IL6
3positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.6IL6, LIF, JAK2
4tyrosine phosphorylation of Stat3 proteinGO:04250310.6LIF, JAK2
5acute-phase responseGO:00695310.6CRP, IL6, SERPINF2, CEBPB
6positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5JAK2, LIF, IL3, IL11, IL6
7positive regulation of DNA replicationGO:04574010.5EPO, IL3, IL6
8platelet degranulationGO:00257610.5PPBP, PF4, FGA, SELP, SERPINF2
9response to lipopolysaccharideGO:03249610.5JAK2, EPO, IL6, SELP, CEBPB
10positive regulation of peptidyl-serine phosphorylationGO:03313810.5IL6, IL11, LIF
11negative regulation of lipid storageGO:01088810.4IL6, CRP
12positive regulation of MAPK cascadeGO:04341010.4LIF, IL11, IL6
13positive regulation of cell proliferationGO:00828410.4JAK2, LIF, EPO, IL3, IL11, IL6
14positive regulation of macrophage differentiationGO:04565110.4LIF, PF4
15platelet activationGO:03016810.3SERPINF2, PPBP, MPL, PF4, FGA, IL11
16positive regulation of protein import into nucleus, translocationGO:03316010.3IL6, JAK2
17blood coagulationGO:00759610.3PPBP, JAK2, MPL, NFE2, CD177, PF4
18inflammatory responseGO:00695410.3CEBPB, SELP, IL6, CRP
19agingGO:00756810.0CRP, EPO, IL6

Molecular functions related to Thrombocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.2THPO, IL6, IL11, IL3, LIF
2growth factor activityGO:0080839.9THPO, PPBP, LIF, IL3, IL11, IL6

Products for genes affiliated with Thrombocytosis

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  • Antibodies
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Sources for Thrombocytosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet