MCID: THR079
MIFTS: 67

Thromboembolism malady

Blood diseases category

Summaries for Thromboembolism

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OMIM:46 Thrombophilia is a multifactorial disorder of inappropriate clot formation resulting from an interaction of genetic,... (188050) more...

MalaCards based summary: Thromboembolism is related to hypertension and patent foramen ovale, and has symptoms including autosomal dominant inheritance, pulmonary embolism and deep venous thrombosis. An important gene associated with Thromboembolism is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are Cell surface interactions at the vascular wall and PTM- gamma carboxylation, hypusine formation and arylsulfatase activation. The drugs heparin and heparin sodium and the compounds ecarin and inogatran have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes, and related mouse phenotypes are respiratory system and integument.

Wikipedia:64 Thrombosis (Greek: ?????????) is the formation of a blood clot (thrombus; Greek: ???????) inside a blood... more...

Aliases & Classifications for Thromboembolism

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Sources:
46OMIM, 44Novoseek, 61UMLS
See all sources

Thromboembolism, Aliases & Descriptions:

Name: Thromboembolism 46 44 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Related Diseases for Thromboembolism

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Diseases related to Thromboembolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 366)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.8F5, PLAT, MTHFR, SERPINE1, F2
2patent foramen ovale31.4F5
3thrombophlebitis30.7F8, APOH
4factor xii deficiency30.7F5, F3
5retinal artery occlusion30.6APOH
6homocystinuria30.6F5, MTHFR, SERPINC1
7endocarditis30.6F10
8antithrombin iii deficiency30.6F5, MTHFR, SERPINC1, APOH, F10, F2
9central retinal artery occlusion30.6PLAT
10primary pulmonary hypertension30.5FGA, THBD
11placental abruption30.5F5, MTHFR, SERPINC1
12behcet's disease30.4F5, APOH, THBD
13sagittal sinus thrombosis30.4F5, SERPINC1
14homocysteinemia30.4F5, MTHFR
15afibrinogenemia30.4FGA
16coronary thrombosis30.3PLAT, F3, SERPINC1, SERPINE1
17eclampsia30.3MTHFR, SERPINC1, THBD
18lupus erythematosus30.1F5, F3, PROCR, SERPINC1, APOH, THBD
19vascular disease30.1F8, F3, SERPINC1, APOH, THBD
20cerebrovascular disease30.1MTHFR, APOH, F12
21portal vein thrombosis30.0F5, F8, MTHFR, SERPINC1, F2
22thrombocytosis30.0FGA, F3, SERPINC1, F10, THBD, F2
23peripheral vascular disease30.0PLAT, MTHFR, F3, THBD
24angioedema29.9PLAT, F12
25dysfibrinogenemia29.9FGA, F5, PLAT, SERPINC1, THBD, F2
26connective tissue disease29.9F3, APOH, THBD, F2
27breast cancer29.9PLAT, MTHFR, PROCR, SULT1A3, SERPINE1, F10
28glanzmann's thrombasthenia29.9F8, F3, F10
29protein c deficiency29.9HRG, F5, MTHFR, PROCR, PROC, SERPINC1
30pulmonary embolism29.9FGA, F5, PLAT, MTHFR, F3, SERPINC1
31factor v deficiency29.8F5, F8, F3, F2
32factor vii deficiency29.7F5, F8, F3, SERPINC1, F10, F2
33liver cirrhosis29.7FGA, SERPINC1, F2
34vasculitis29.6FGA, SULT1A3, APOH, THBD, F2
35hyperhomocysteinemia29.6HRG, F5, PLAT, F8, MTHFR, SERPINC1
36thrombocytopenia29.5FGA, F5, F8, F3, SERPINC1, APOH
37factor xi deficiency29.4F5, F8, F3, F12, F11, F2
38protein s deficiency29.4FGA, F5, F8, MTHFR, F3, SERPINC1
39antiphospholipid syndrome29.3F5, PLAT, F8, MTHFR, F3, PROCR
40congenital heart disease29.1F8, MTHFR, F3, SERPINE1, F12, THBD
41systemic lupus erythematosus29.1FGA, F8, F3, PROCR, SULT1A3, APOH
42atherosclerosis29.0FGA, PLAT, MTHFR, F3, PROCR, SULT1A3
43acute myocardial infarction28.7FGA, HRG, PLAT, F3, SULT1A3, SERPINC1
44sepsis28.6FGA, F5, F3, PROCR, PROC, SULT1A3
45disseminated intravascular coagulation28.6FGA, F5, PLAT, F8, F3, PROC
46myocardial infarction28.3FGA, HRG, F5, PLAT, F8, MTHFR
47thrombophilia28.1FGA, HRG, F5, PLAT, F8, MTHFR
48pre-eclampsia28.1FGA, F5, PLAT, F8, MTHFR, F3
49venous thrombosis27.3FGA, HRG, F5, PLAT, F8, MTHFR
50venous thromboembolism11.3

Graphical network of the top 20 diseases related to Thromboembolism:



Diseases related to thromboembolism

Symptoms for Thromboembolism

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Symptoms by clinical synopsis from OMIM:

188050

Clinical features from OMIM:

188050

HPO human phenotypes related to Thromboembolism:

(show all 6)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 pulmonary embolism HP:0002204
3 deep venous thrombosis HP:0002625
4 recurrent thrombophlebitis HP:0004419
5 cerebral venous thrombosis HP:0005305
6 childhood onset HP:0011463

Drugs & Therapeutics for Thromboembolism

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Genetic Tests for Thromboembolism

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Anatomical Context for Thromboembolism

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MalaCards organs/tissues related to Thromboembolism:

32
Lung, Heart, Testes, Endothelial, Brain, Breast, Liver, Lymph node, Kidney, Spinal cord, Neutrophil, Skin, Ovary, Monocytes, B cells, Bone, Whole blood, Spleen, Smooth muscle, Placenta, Prostate, Cervix

Animal Models for Thromboembolism or affiliated genes

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Publications for Thromboembolism

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Articles related to Thromboembolism:

(show top 50)    (show all 2097)
idTitleAuthorsYear
1
Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis. (24424839)
2014
2
Venous Thromboembolism following Elective Aesthetic Plastic Surgery: A Longitudinal Prospective Study in 1254 Patients. (25374678)
2014
3
Recent advances of pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension including Japanese experiences. (24068659)
2014
4
Extended Venous Thromboembolism Prophylaxis After Colorectal Cancer Resection: A UK Perspective. (25371122)
2014
5
Role of protein S deficiency in children with venous thromboembolism. An observational international cohort study. (25272994)
2014
6
Adherence With Postdischarge Venous Thromboembolism Chemoprophylaxis Recommendations After Colorectal Cancer Surgery Among Elderly Medicare Beneficiaries. (24169191)
2013
7
Saddle pulmonary thromboembolism. (24222701)
2013
8
Comparing clinical predictors of deep venous thrombosis versus pulmonary embolus after severe injury: a new paradigm for posttraumatic venous thromboembolism? (23609272)
2013
9
Balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension. (23846611)
2013
10
Is tamoxifen associated with an increased risk for thromboembolic complications in patients undergoing microvascular breast reconstruction? (23423877)
2013
11
Prolonged outpatient vitamin K antagonist use and risk of venous thromboembolism in patients undergoing total hip or knee replacement. (23387806)
2013
12
Commentary on "Venous Thromboembolism After Face-Lift Surgery Using Local Anesthesia: Results of a Multicenter Survey" (24149626)
2013
13
Intermittent pneumatic compression is effective in reducing venous thromboembolism risk in hospitalised patients. (24361752)
2013
14
Neonatal systemic thromboembolism secondary to ductus arteriosus aneurysm and patent foramen ovale. (21801317)
2013
15
Risk of recurrence of unusual site venous thromboembolism. (23756963)
2013
16
Clinical outcomes of thromboendarterectomy for chronic thromboembolic pulmonary hypertension: 12-year experience. (23423163)
2013
17
Venous thromboembolism prevention in pediatric trauma-time for national guidelines. (24173133)
2013
18
Risk factors for pregnancy-associated venous thromboembolism: a review. (24334422)
2013
19
Validation of the clinical prediction rule for recurrent venous thromboembolism in cancer patients: the Ottawa score. (23525939)
2013
20
Management of venous thromboembolism--controversies and the future. (23531017)
2013
21
Educational outreach visits to improve nurses' use of mechanical venous thromboembolism prevention in hospitalized medical patients. (24238096)
2013
22
Fatal venous thromboembolism associated with hospital admission: a cohort study to assess the impact of a national risk assessment target. (24038168)
2013
23
Myometrial cavernous hemangioma with pulmonary thromboembolism in a post-partum woman: a case report and review of the literature. (23176111)
2012
24
Influence of the factor II G20210A variant or the factor V G1691A mutation on symptomatic recurrent venous thromboembolism in children: an international multicenter cohort study. (18983482)
2009
25
Long-term outcome after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: a single institution experience. (19272789)
2009
26
Should patients with venous thromboembolism be screened for thrombophilia? (18501222)
2008
27
The angiotensin-converting enzyme insertion/deletion polymorphism and serum levels of angiotensin-converting enzyme in venous thromboembolism. Data from a case control study. (17938801)
2007
28
Dose-escalation study of rivaroxaban (BAY 59-7939)--an oral, direct Factor Xa inhibitor--for the prevention of venous thromboembolism in patients undergoing total hip replacement. (17292948)
2007
29
The risk for thromboembolic disease in lupus anticoagulant patients due to pathways involving P-selectin and CD154. (17393020)
2007
30
Study on the relationship between polymorphisms of susceptible genes in coagulation pathway related to pulmonary thromboembolism in Chinese Han population]. (16750002)
2006
31
Effects of pulmonary thromboendarterectomy on right-sided echocardiographic parameters in patients with chronic thromboembolic pulmonary hypertension. (16770978)
2006
32
Factor V Leiden as a common genetic risk factor for venous thromboembolism. (16579319)
2006
33
Haptoglobin phenotype 2-2 as a potentially new risk factor for spontaneous venous thromboembolism. (16266904)
2005
34
Challenges in the prevention of venous thromboembolism in the elderly. (15304033)
2004
35
Risk of venous thromboembolism during pregnancy in homozygous carriers of the factor V Leiden mutation: are there any predictive factors? (14996015)
2004
36
A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism. (15297315)
2004
37
Combined protein C and protein S deficiency in a family with repetitive thromboembolism and segregated gene mutations. (12705793)
2003
38
The risk of venous thromboembolism associated with the factor V Leiden mutation and low B-vitamin status. (14580166)
2003
39
Pregnancy-associated venous thromboembolism (VTE) in combined heterozygous factor V Leiden (FVL) and prothrombin (FII) 20210 A mutation and in heterozygous FII single gene mutation alone. (14531916)
2003
40
Thromboembolism after ovarian stimulation: successful management of a woman with superior sagittal sinus thrombosis after IVF and embryo transfer: case report. (14585890)
2003
41
Clinical study of venous thromboembolism during pregnancy and puerperium. (11372769)
2001
42
Prevalence of factor V Leiden and prothrombin 20210 A variant in Bulgarian patients with pulmonary thromboembolism and deep venous thrombosis. (11734663)
2001
43
Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis. (11071624)
2000
44
Surgical treatment of chronic thromboembolic pulmonary hypertension. (10700671)
2000
45
Increased lipoprotein(a) is an important risk factor for venous thromboembolism in childhood. (10449697)
1999
46
Prevalence of the factor VLeiden mutation among autopsy patients with pulmonary thromboembolic disease using an improved method for factor VLeiden detection. (10078118)
1999
47
Surgical treatment for chronic thromboembolic pulmonary hypertension under profound hypothermia and circulatory arrest in 24 patients. (10875595)
1999
48
Recurrent venous thromboembolic disease and factor XI concentrate in a patient with severe factor XI deficiency, chronic myelomonocytic leukaemia, factor V Leiden and heterozygous plasminogen deficiency. (9391725)
1997
49
Platelet thromboembolism. (8013531)
1994
50
Etiology and pathogenesis of spontaneous venous thromboembolism]. (8273075)
1993

Variations for Thromboembolism

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Clinvar genetic disease variations for Thromboembolism:

7
id Gene Name Type Significance SNP ID Assembly Location
1F2NM_000506.3(F2): c.*97G> Asingle nucleotide variantPathogenic, risk factorrs1799963GRCh37Chr 11, 46761055: 46761055
2F2NM_000506.3(F2): c.1787G> T (p.Arg596Leu)single nucleotide variantPathogenicrs387907201GRCh37Chr 11, 46760876: 46760876

Expression for genes affiliated with Thromboembolism

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Expression patterns in normal tissues for genes affiliated with Thromboembolism

Search GEO for disease gene expression data for Thromboembolism.

Pathways for genes affiliated with Thromboembolism

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Pathways related to Thromboembolism according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7PROC, THBD, F2
2
Show member pathways
9.6PROC, F10, F2
3
Show member pathways
thioredoxin pathway37
9.5F2, SERPINE1, MTHFR, PLAT
49.4APOH, PROC, F8
59.3HRG, PLAT, SERPINE1
6
Show member pathways
9.1SERPINE1, PLAT, FGA
78.9FGA, PLAT, F12
8
Show member pathways
8.0SERPINE1, F8, F5, HRG, FGA
9
Show member pathways
6.2F2, THBD, F10, F11, F12, SERPINC1
10
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
5.6F11, F12, SERPINE1, SERPINC1, PROC, F3
11
Show member pathways
5.6F2, THBD, F10, F11, F12, SERPINE1
12
Show member pathways
4.9F11, F12, SERPINE1, SERPINC1, PROC, F3

Compounds for genes affiliated with Thromboembolism

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Compounds related to Thromboembolism according to GeneCards/GeneDecks:

(show top 50)    (show all 208)
idCompoundScoreTop Affiliating Genes
1ecarin449.4F5, F3, SERPINC1, F10, F2
2inogatran449.4F2, F5, F3, SERPINC1
3danaparoid449.4F2, F10, F3, SERPINC1, F5
4ximelagatran44 1210.2F5, F3, SERPINC1, F10, THBD, F2
5coumarins449.2F5, F3, F2, APOH, F10
6heparinoids449.2F10, SERPINC1, F3, F5, THBD, F2
7spectrozyme449.2SERPINC1, F10, F2, F3, PLAT, F5
8protamine sulfate449.2F2, F10, SERPINC1, F3, PLAT, F5
9hirugen449.1F2, F5, SERPINC1, THBD, FGA
10tranexamic acid44 1210.0F2, PLAT, F8, F3, SERPINC1, SERPINE1
11fibrinopeptide a448.9SERPINC1, THBD, F2, FGA, PLAT
12fondaparinux448.9F5, PLAT, F3, SERPINC1, F10, THBD
13batroxobin448.9F5, SERPINE1, PLAT, F2, FGA
14efegatran448.9PLAT, F3, SERPINC1, F10
15tirofiban44 129.9PLAT, F3, SERPINC1, F2, F10
16gamma-carboxyglutamic acid448.9F5, F3, PROCR, PROC, F10, THBD
17phosphatidylethanolamine44 129.9F2, HABP2, APOH, F5, F8, PROCR
1811-dehydrothromboxane b2448.8FGA, SERPINE1, F2, THBD, APOH
19cardiolipin44 129.7APOH, F5, F8, F3, F10, F2
20epsilon aminocaproic acid448.7SERPINC1, F3, PLAT, HRG, F2, SERPINE1
21ppack448.6PLAT, F3, SERPINC1, F10, F2, FGA
22dextran sulfate448.6F11, APOH, F3, F5, SERPINC1, F10
23kaolin448.5F12, F10, F2, APOH, F3, F5
24ristocetin448.5F2, F5, PLAT, F8, F3, SERPINC1
25coumarin44 3 50 2511.5F2, F10, SERPINC1, F3, FGA, F5
26pge1448.3F5, FGA, F2, PLAT, SERPINE1, APOH
27citrate448.3F10, THBD, F5, F8, F3, F2
28cacl2448.2FGA, F5, F8, F3, F10, THBD
29ancrod448.2F2, THBD, F10, SERPINE1, SERPINC1, PLAT
30argatroban44 129.1SERPINC1, F10, THBD, F2, F3, PLAT
31bivalirudin44 129.1F5, PLAT, F3, SERPINC1, F10, THBD
32protamine448.1F5, FGA, PLAT, F2, F10, SERPINE1
33desmopressin44 60 29 1210.9F8, F3, SERPINC1, SERPINE1, F11, THBD
34heparan sulfate44 258.9F10, HRG, F11, SERPINC1, PLAT, SERPINE1
35dermatan sulfate447.8F2, THBD, F10, F11, SERPINC1, F3
36phospholipid447.6APOH, F11, F10, THBD, F2, PROC
37aspartate447.6PLAT, SULT1A3, F3, MTHFR, F5, SERPINE1
38prostacyclin447.5FGA, F5, THBD, APOH, SERPINE1, SERPINC1
39endotoxin447.4APOH, F11, THBD, SERPINE1, PROCR, FGA
40aprotinin44 128.3FGA, F2, F5, PLAT, F3, SERPINC1
41estrogen447.3F5, F8, F10, THBD, F2, F12
42homocysteine44 258.1THBD, F2, F11, APOH, F5, PLAT
43kininogen446.9PLAT, F3, SERPINC1, SERPINE1, APOH, F12
44creatinine446.8FGA, F5, PLAT, F8, MTHFR, F3
45warfarin44 50 25 129.7PROC, F2, THBD, F10, APOH, SERPINC1
46hirudin446.5SERPINE1, SERPINC1, PROCR, F8, PLAT, F5
47aspirin44 50 29 259.1F3, SULT1A3, SERPINC1, SERPINE1, APOH, F12
48serine444.7FGA, HRG, F5, SERPINC1, SERPINE1, F12
49heparin44 29 25 127.2SULT1A3, SERPINC1, SERPINE1, APOH, F12, F11
50fibrinogen444.1F10, F2, HABP2, SERPINC1, SERPINE1, APOH

GO Terms for genes affiliated with Thromboembolism

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Cellular components related to Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic component of external side of plasma membraneGO:0312339.6F10, F3
2endoplasmic reticulum lumenGO:0057889.6PROC, F10, F2
3Golgi lumenGO:0057969.3PROC, F10, F2
4extracellular matrixGO:0310129.2PLAT, F3, SERPINE1, APOH
5blood microparticleGO:0725628.7F2, SERPINC1, HRG, FGA
6cell surfaceGO:0099868.5THBD, APOH, F3, PLAT, FGA
7platelet alpha granule lumenGO:0310938.2SERPINE1, F8, F5, HRG, FGA
8extracellular spaceGO:0056156.0FGA, F2, HABP2, THBD, F11, F12
9extracellular regionGO:0055765.6F12, F11, F10, HABP2, F2, SERPINE1
10plasma membraneGO:0058865.4F2, THBD, F10, F11, F12, SERPINE1

Biological processes related to Thromboembolism according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of proteolysisGO:04586110.0PLAT, F2
2negative regulation of platelet activationGO:0105449.9THBD, F2
3blood coagulation, extrinsic pathwayGO:0075989.9F3, F10
4peptidyl-glutamic acid carboxylationGO:0171879.8PROC, F10, F2
5regulation of blood coagulationGO:0301939.7F2, HRG
6positive regulation of fibrinolysisGO:0519199.6F12, F11
7negative regulation of cell adhesion mediated by integrinGO:0336299.6HRG, SERPINE1
8plasminogen activationGO:0316399.6F11, APOH, PLAT
9negative regulation of blood coagulationGO:0301959.6THBD, APOH, SERPINE1, PROC
10positive regulation of blood coagulationGO:0301949.6SERPINE1, APOH, F12, F2
11proteolysisGO:0065089.5F2, F10, PROC, PLAT
12leukocyte migrationGO:0509009.4PROC, THBD, F2
13negative regulation of fibrinolysisGO:0519189.1F2, THBD, APOH, SERPINE1, HRG
14fibrinolysisGO:0427308.9F2, F12, SERPINE1, PLAT, HRG
15blood coagulation, intrinsic pathwayGO:0075978.5F2, F10, F11, F12, APOH, F8
16platelet degranulationGO:0025768.3SERPINE1, F8, F5, HRG, FGA
17platelet activationGO:0301688.0F2, SERPINE1, F8, F5, HRG, FGA
18blood coagulationGO:0075965.1FGA, F2, THBD, F10, F11, F12

Molecular functions related to Thromboembolism according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1serine-type aminopeptidase activityGO:0700099.6F12, F11
2protease bindingGO:0020209.6F3, SERPINC1, SERPINE1
3phospholipid bindingGO:0055439.4F10, APOH, F3
4serine-type endopeptidase inhibitor activityGO:0048679.3HRG, SERPINC1, SERPINE1
5heparin bindingGO:0082018.9F11, APOH, SERPINC1, HRG
6receptor bindingGO:0051028.2FGA, HRG, SERPINE1, F2
7serine-type endopeptidase activityGO:0042527.5F5, F2, HABP2, F10, F11, F12
8protein bindingGO:0055154.6SERPINE1, APOH, F12, F11, F10, THBD

Products for genes affiliated with Thromboembolism

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Sources for Thromboembolism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet