MCID: THR079
MIFTS: 63

Thromboembolism malady

Blood category

Summaries for Thromboembolism

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Thrombosis (Greek: θρόμβωσις) is the formation of a blood clot (thrombus; Greek:... more...

MalaCards: Thromboembolism is related to thrombophilia and venous thrombosis. An important gene associated with Thromboembolism is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The drugs heparin and heparin sodium and the compounds fibrinogen and aspirin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and brain, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Description from OMIM:47 188050

Aliases & Classifications for Thromboembolism

Sources:
47OMIM, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

thromboembolism 47 45 61


Related Diseases for Thromboembolism

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Thromboembolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 336)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophilia31.1SERPINC1, SERPINE1, THBD, PLAT, F2, FGA
2venous thrombosis30.8SERPINC1, SERPINE1, SULT1A3, THBD, PLAT, F2
3primary pulmonary hypertension30.6NOS3, THBD, FGA
4protein c deficiency30.6SERPINC1, SERPINE1, THBD, F2, PROC, PROCR
5antiphospholipid syndrome30.6SERPINC1, SULT1A3, THBD, PLAT, F2, PROCR
6hyperhomocysteinemia30.6SERPINC1, SERPINE1, NOS3, THBD, PLAT, F2
7thrombocytopenia30.5SERPINC1, THBD, F2, FGA, F7, F10
8protein s deficiency30.5SERPINC1, SERPINE1, F2, FGA, MTHFR, F5
9patent foramen ovale30.4F5
10thrombocytosis30.4SERPINC1, THBD, F2, FGA, F10
11systemic lupus erythematosus30.3SULT1A3, THBD, F2, FGA, PROCR, F10
12arthritis30.3SULT1A3, F10
13colorectal cancer30.2MTHFR
14atherosclerosis30.2SERPINC1, SERPINE1, SULT1A3, NOS3, THBD, PLAT
15vascular disease30.2SERPINC1, SERPINE1, SULT1A3, NOS3, THBD, PLAT
16dysfibrinogenemia30.1SERPINC1, THBD, PLAT, F2, FGA, F5
17factor v deficiency30.1F2, F5, F8
18sickle cell disease30.1NOS3, FGA
19thrombophlebitis30.1F8, APOH
20ovarian hyperstimulation syndrome30.1F5
21amyloidosis30.1F10
22acute leukemia30.1FGA, MTHFR
23acute myocardial infarction30.0SERPINC1, SERPINE1, SULT1A3, THBD, PLAT, FGA
24coronary thrombosis30.0SERPINC1, SERPINE1, PLAT
25adenocarcinoma30.0THBD, HABP2, TNXA
26stroke, ischemic30.0F2, F5
27intracranial aneurysm30.0NOS3
28factor v leiden thrombophilia29.9SERPINC1, SERPINE1, THBD, PLAT, F2, P2RY12
29sepsis29.9SERPINC1, SERPINE1, SULT1A3, NOS3, THBD, F2
30portal vein thrombosis29.9SERPINC1, F2, MTHFR, F5, F8
31homocystinuria29.9SERPINC1, MTHFR, F5
32placental abruption29.9SERPINC1, MTHFR, F5
33varicose veins29.9F2
34polycystic ovary syndrome29.9SERPINE1
35polycythemia vera29.9THBD
36asthma29.9F10
37coronary heart disease29.7SERPINC1, SERPINE1, SULT1A3, NOS3, THBD, PLAT
38coronary artery disease,29.7SERPINE1, NOS3, THBD, PLAT, P2RY12, FGA
39pregnancy loss29.7SERPINC1, F2, F10, MTHFR, F5, F8
40insulin resistance29.7SERPINE1, NOS3, PLAT, F7, F8
41eclampsia29.7SERPINC1, THBD, MTHFR
42peripheral vascular disease29.7THBD, PLAT, MTHFR
43glanzmann's thrombasthenia29.7F10, F8, TNXA
44arteriosclerosis29.7SERPINE1, NOS3, MTHFR
45central retinal artery occlusion29.7PLAT
46homocysteinemia29.7MTHFR, F5
47behcet's disease29.7THBD, F5, APOH
48carotid stenosis29.7HABP2
49acute pancreatitis29.7SULT1A3
50sagittal sinus thrombosis29.7SERPINC1, F5

Graphical network of the top 20 diseases related to Thromboembolism:



Diseases related to thromboembolism

Clinical Features for Thromboembolism

Sources:
47OMIM
See all sources

Clinical features from OMIM:

188050

Clinical synopsis from OMIM:

188050

Drugs & Therapeutics for Thromboembolism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Thromboembolism

Anatomical Context for Thromboembolism

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Thromboembolism:

33
Whole blood, Lymph node, Brain, Spinal cord, Heart, Small intestine, Kidney, Liver, Lung, Breast, Skin, Ovary, Placenta, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung

Animal Models for Thromboembolism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Thromboembolism

Sources:
51PubMed
See all sources

Articles related to Thromboembolism:

(show top 50)    (show all 1367)
idTitleAuthorsYear
1
Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis. (24424839)
2014
2
Non-o blood type is associated with an increased risk of venous thromboembolism after radical cystectomy. (24139524)
2014
3
Venous thromboembolism prophylaxis for patients receiving regional anesthesia following injury in Iraq and Afghanistan. (24368371)
2014
4
Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis. (23645857)
2013
5
Review Article: Venous thromboembolism after total joint replacement. (24366799)
2013
6
Stratified meta-analysis of intermittent pneumatic compression of the lower limbs to prevent venous thromboembolism in hospitalized patients. (23852609)
2013
7
The incidence, risk factors, and prognosis of recurrent venous thromboembolism (VTE) in patients with advanced solid cancers receiving anticoagulation therapy after the diagnosis of index VTE. (23399441)
2013
8
In search of venous thromboembolism: the first 2913 years. (24059395)
2013
9
Distinct frequencies and mutation spectrums of genetic thrombophilia in Korea in comparison with other Asian countries both in patients with venous thromboembolism and in general population. (24162787)
2013
10
Alcohol intake and risk of venous thromboembolism. A Danish follow-up study. (23595624)
2013
11
Venous thromboembolism: prophylactic and therapeutic practice guideline. (23547704)
2013
12
Serum levels of vitamin D are not associated with future risk of venous thromboembolism. The TromsA, Study. (23446951)
2013
13
Primary Thromboprophylaxis in Hospices: The Association Between Risk of Venous Thromboembolism and Development of Symptoms. (24331547)
2013
14
Prospective study of venous thromboembolism in patients with head and neck cancer after surgery: interim analysis. (23429947)
2013
15
Congenital absence of inferior vena cava with azygos continuation revealed by vascular echo in a patient with pulmonary thromboembolism and deep vein thrombosis: a case report. (23825501)
2013
16
Intra-arterial infusion of a glycoprotein IIb/IIIa antagonist for the treatment of thromboembolism during coil embolization of intracranial aneurysm: a comparison of abciximab and tirofiban. (23660289)
2013
17
A review of venous thromboembolism prophylaxis for hospitalized medical patients. (23948622)
2013
18
Venous thromboembolism in neonates and children--update 2013. (23452739)
2013
19
Prevention of venous thromboembolism in acutely ill medical patients after the results of recent trials with the new oral anticoagulants. (23857035)
2013
20
Pharmacologic Prophylaxis, Postoperative INR, and Risk of Venous Thromboembolism after Hepatectomy. (24129829)
2013
21
Extended anticoagulation in venous thromboembolism. (23758243)
2013
22
Comparative safety and efficacy of antithrombotics in the management of venous thromboembolism after knee or hip replacement surgery: focus on rivaroxaban. (23946671)
2013
23
Contraception-related venous thromboembolism in a pediatric institution. (23566795)
2013
24
Reduction of venous thromboembolism (VTE) in hospitalized patients: aligning continuing education with interprofessional team-based quality improvement in an academic medical center. (23969376)
2013
25
A prospective study on the incidence of postoperative venous thromboembolism in Korean gastric cancer patients: an inquiry into the application of Western guidelines to Asian cancer patients. (23613988)
2013
26
Incidence of venous thromboembolism in otolaryngology-head and neck surgery. (23329088)
2013
27
Recommendations for prophylaxis of pregnancy-related venous thromboembolism in carriers of inherited thrombophilia. Comment on the 2012 ACCP guidelines: a rebuttal. (23819793)
2013
28
Interaction between blood type, smoking and factor V Leiden mutation and risk of venous thromboembolism: a Danish case-cohort study. (22577971)
2012
29
Venous thromboembolism in patients with essential thrombocythemia and polycythemia vera. (22076463)
2012
30
Thrombophilia in women with pregnancy-associated complications: fetal loss and pregnancy-related venous thromboembolism. (20068329)
2010
31
Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism. (20603037)
2010
32
Cerebral arteriolar thromboembolism in idiopathic hypereosinophilic syndrome. (19364940)
2009
33
Thrombophilia testing in patients with venous thromboembolism. Findings from the RIETE registry. (19101711)
2009
34
Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study. (17846285)
2007
35
Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden. (17139368)
2006
36
The effect of venous thromboembolism on survival of cancer patients and its relationship with serum levels of factor VIII and vascular endothelial growth factor: a prospective matched-paired study. (17177157)
2006
37
Haptoglobin phenotype 2-2 as a potentially new risk factor for spontaneous venous thromboembolism. (16266904)
2005
38
Thromboembolism in heart transplantation: role of prothrombin G20210A and factor V Leiden. (16177630)
2005
39
49, XXXXY syndrome with unilateral renal aplasia, proteinuria, and venous thromboembolism. (15645656)
2004
40
The concentrations of soluble vascular cell adhesion molecule-1 and lipids are independently associated with venous thromboembolism. (12969812)
2003
41
Fondaparinux for prevention of venous thromboembolism in major orthopedic surgery. (14565815)
2003
42
Incidence of venous thromboembolism in asymptomatic family members who are carriers of factor V Leiden: a prospective cohort study. (11877263)
2002
43
Impact of the factor II: G20210A variant on the risk of venous thromboembolism in relatives from families with the factor V: R506Q mutation. (11737249)
2001
44
Major and potential prothrombotic genotypes in a cohort of patients with venous thromboembolism. (11738073)
2001
45
Mild hyperhomocysteinemia and fibrinolytic factors in patients with history of venous thromboembolism. (11113270)
2000
46
The relationship between polymorphisms in the endothelial cell nitric oxide synthase gene and the platelet GPIIIa gene with myocardial infarction and venous thromboembolism in African Americans. (10531147)
1999
47
Coinheritance of the HR2 haplotype in the factor V gene confers an increased risk of venous thromboembolism to carriers of factor V R506Q (factor V Leiden). (10556190)
1999
48
Postoperative venous thromboembolism and brain tumors: Part III. Biochemical profile. (1331347)
1992
49
Impaired fibrinolysis and postoperative thromboembolism in orthopedic patients. (1853306)
1991
50
Thromboembolism and bleeding tendency in congenital factor XII deficiency--a study on 74 subjects from 14 Swiss families. (1905067)
1991

Genetic Variations for Thromboembolism

Expression for genes affiliated with Thromboembolism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Thromboembolism

Search GEO for disease gene expression data for Thromboembolism.

Pathways for genes affiliated with Thromboembolism

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 52QIAGEN, 50PharmGKB, 12EMD Millipore
See all sources

Pathways related to Thromboembolism according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1SERPINC1, SERPINE1, THBD, PLAT, F2, FGA
2
Hide members
11.1FGA, F7, PROC, F10, F5, F8
3
Hide members
11.1F8, F5, F10, PROC, F7, FGA
4
Hide members
11.0F5, SERPINC1, THBD, F2, FGA, F7
5
Hide members
10.8FGA, P2RY12, F2, THBD, NOS3
610.8MTHFR, F7, F2, PLAT, SERPINE1
7
Hide members
10.8F8, F5, F10, PROC, F7
8
Hide members
10.7F8, F5, FGA, SERPINE1
910.7F2, F7, PROC, F10
10
Hide members
10.7F2, F7, PROC, F10
1110.7F2, P2RY12, FGA
12
Cell adhesion ECM remodeling
Hide members
10.7SERPINE1, PLAT, FGA
1310.7THBD, F2, PROC
1410.7PROC, F8, APOH
1510.6PLAT, SERPINE1

Compounds for genes affiliated with Thromboembolism

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 24HMDB, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Thromboembolism according to GeneCards/GeneDecks:

(show top 50)    (show all 200)
idCompoundScoreTop Affiliating Genes
1fibrinogen4512.0TNXA, APOH, SERPINC1, SERPINE1, SULT1A3, THBD
2aspirin45 50 29 2414.8SERPINC1, SERPINE1, SULT1A3, NOS3, THBD, PLAT
3creatinine4511.7P2RY12, FGA, F7, MTHFR, F5, F8
4hirudin4511.6TNXA, F8, F5, F10, PROCR, FGA
5homocysteine45 2412.6MTHFR, F2, PLAT, THBD, NOS3, SULT1A3
6kininogen4511.5APOH, HABP2, SERPINC1, SERPINE1, THBD, PLAT
7argatroban45 1112.4F2, THBD, SERPINC1, PLAT, FGA, TNXA
8prostacyclin4511.4F8, SERPINC1, SERPINE1, NOS3, THBD, PLAT
9gamma-carboxyglutamic acid4511.4TNXA, F5, F10, PROCR, PROC, F7
10protamine4511.4SERPINC1, SERPINE1, PLAT, F2, FGA, F10
11ancrod4511.4F5, F10, FGA, F2, SERPINC1, SERPINE1
12bivalirudin45 1112.4F5, F10, FGA, F2, PLAT, THBD
13pge14511.4APOH, SERPINE1, THBD, PLAT, F2, P2RY12
14phospholipid4511.3F10, APOH, F5, TNXA, F2, THBD
15desmopressin45 60 29 1114.3THBD, F8, F5, F2, PLAT, SERPINE1
16fondaparinux4511.3TNXA, F5, F10, F2, PLAT, THBD
17aprotinin45 1112.3F10, SERPINC1, SERPINE1, THBD, PLAT, FGA
18clopidogrel50 45 11 2414.3P2RY12, SERPINC1, TNXA, F10, F2, PLAT
19endotoxin4511.3FGA, F8, F5, PROCR, SERPINE1, APOH
20cholesterol45 29 11 2414.3PLAT, THBD, SERPINE1, F5, FGA, F7
21dermatan sulfate4511.3THBD, PLAT, TNXA, F5, F10, F2
22heparin45 29 11 2414.3P2RY12, FGA, F10, MTHFR, F8, APOH
23Drotrecogin alfa1111.3F5, PROCR, F8, F2, THBD, SERPINE1
24ppack4511.2PLAT, P2RY12, SERPINC1, F2, FGA, F10
25serine4511.2FGA, F7, PROCR, F10, F8
26hirugen4511.2F5, SERPINC1, F2, THBD, FGA
27warfarin45 50 11 2414.2SERPINC1, APOH, PROC, FGA
28spectrozyme4511.2SERPINC1, PLAT, F2, F10, F5
29batroxobin4511.1SERPINE1, PLAT, F2, F5, FGA
30fibrinopeptide a4511.1SERPINC1, THBD, PLAT, F2, FGA
31danaparoid4511.1F10, F2, TNXA, F5, SERPINC1
32ximelagatran45 1112.1F2, F10, THBD, SERPINC1, F5
33kaolin4511.1APOH, F2, F10, F8, F5
34heparinoids4511.1SERPINC1, THBD, F5, F10, F2
35phosphatidylethanolamine45 1112.1F8, HABP2, F5, PROCR, F2, APOH
36aspartate4511.1F2, F10, F8, SULT1A3, F7
3711-dehydrothromboxane b24511.1FGA, SERPINE1, THBD, F2, APOH
38citrate4511.1F2, NOS3, F8, F10, F5, SERPINC1
39protamine sulfate4511.1PLAT, SERPINC1, F2, F5, F10
40tranexamic acid45 1112.0F8, F2, PLAT, SERPINE1, SERPINC1
41tirofiban45 1112.0F2, F10, P2RY12, PLAT, SERPINC1
42cacl24511.0F5, F10, FGA, F8, THBD
43simvastatin45 50 60 29 11 2416.0PLAT, SERPINE1, THBD, NOS3, F10, F5
44ecarin4510.9F2, F5, F10, SERPINC1
45cardiolipin45 1111.8F10
46cyclophosphamide45 50 1112.8F8, MTHFR, F5, THBD, APOH, SERPINE1
47ristocetin4510.8F2, SERPINC1, PLAT, F5, F8
48levonorgestrel45 60 29 1113.8F5, SERPINC1, PLAT, F2, F7
49estrogen4510.8APOH, SULT1A3, F8
50ticlopidine45 1111.5FGA, APOH, PLAT, P2RY12, SERPINC1

GO Terms for genes affiliated with Thromboembolism

Sources:
16Gene Ontology
See all sources

Cellular components related to Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.2HABP2, F8, F5, F10, PROC, F7
2extracellular spaceGO:00561511.2SERPINC1, APOH, HABP2, F8, F5, F7
3plasma membraneGO:00588610.9F7, PROC, F10, F5, F8, FGA
4platelet alpha granule lumenGO:03109310.7F8, F5, FGA, SERPINE1
5endoplasmic reticulum lumenGO:00578810.7F2, F7, PROC, F10
6Golgi lumenGO:00579610.6F2, F7, PROC, F10

Biological processes related to Thromboembolism according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.6SERPINC1, F8, F5, F10, PROCR, PROC
2platelet activationGO:03016811.0SERPINE1, F2, P2RY12, FGA, F5, F8
3negative regulation of fibrinolysisGO:05191811.0APOH, F2, THBD, SERPINE1
4positive regulation of blood coagulationGO:03019411.0APOH, F7, F2, SERPINE1
5peptidyl-glutamic acid carboxylationGO:01718711.0F10, PROC, F7, F2
6negative regulation of blood coagulationGO:03019511.0APOH, PROC, THBD, SERPINE1
7blood coagulation, intrinsic pathwayGO:00759710.9APOH, F8, F10, F2
8proteolysisGO:00650810.9PLAT, F2, F7, PROC, F10, HABP2
9platelet degranulationGO:00257610.9SERPINE1, FGA, F5, F8
10negative regulation of platelet activationGO:01054410.8F2, THBD, NOS3
11fibrinolysisGO:04273010.8F2, PLAT, SERPINE1
12post-translational protein modificationGO:04368710.6F2, F7, PROC, F10
13negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.6SERPINE1, NOS3
14blood coagulation, extrinsic pathwayGO:00759810.6F10, F7
15plasminogen activationGO:03163910.3PLAT, APOH

Molecular functions related to Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0PROCR, F10, F5, F8, APOH, PROC
2serine-type endopeptidase activityGO:00425210.7PLAT, F2, F7, PROC, F10, HABP2
3receptor bindingGO:00510210.7SERPINE1, F2, FGA, F7

Products for genes affiliated with Thromboembolism

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thromboembolism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet