MCID: THR079
MIFTS: 50

Thromboembolism malady

Blood diseases category

Summaries for Thromboembolism

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Thrombosis (Greek: θρόμβωσις) is the formation of a blood clot (thrombus; Greek:... more...

MalaCards: Thromboembolism is related to hypertension and thrombophilia. An important gene associated with Thromboembolism is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The drugs heparin and heparin sodium and the compounds fibrinogen and aspirin have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Description from OMIM:46 188050

Aliases & Classifications for Thromboembolism

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46OMIM, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

thromboembolism 46 44 60


Related Diseases for Thromboembolism

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17GeneCards, 18GeneDecks
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Diseases related to Thromboembolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 340)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.6SERPINE1, NOS3, PLAT, F2, MTHFR, F5
2thrombophilia31.0SERPINC1, SERPINE1, THBD, PLAT, F2, FGA
3protein c deficiency30.8SERPINC1, SERPINE1, THBD, F2, PROC, PROCR
4pulmonary embolism30.7SERPINC1, PLAT, F2, FGA, F10, MTHFR
5primary pulmonary hypertension30.6NOS3, THBD, FGA
6antiphospholipid syndrome30.6SERPINC1, SULT1A3, THBD, PLAT, F2, PROCR
7hyperhomocysteinemia30.5SERPINC1, SERPINE1, NOS3, THBD, PLAT, F2
8protein s deficiency30.5SERPINC1, SERPINE1, F2, FGA, MTHFR, F5
9antithrombin iii deficiency30.5SERPINC1, F2, F10, MTHFR, F5, APOH
10myocardial infarction30.5SERPINC1, SERPINE1, SULT1A3, NOS3, PLAT, P2RY12
11thrombocytopenia30.5SERPINC1, THBD, F2, FGA, F7, F10
12nephrotic syndrome30.5SERPINC1, FGA
13obesity30.4SERPINE1, SULT1A3, NOS3, F7
14patent foramen ovale30.4F5
15thrombocytosis30.3SERPINC1, THBD, F2, FGA, F10
16systemic lupus erythematosus30.3SULT1A3, THBD, F2, FGA, PROCR, F10
17lupus erythematosus30.3SERPINC1, THBD, F2, PROCR, F5, APOH
18breast cancer30.3SERPINE1, SULT1A3, PLAT, PROCR, F10, MTHFR
19arthritis30.3SULT1A3, F10
20colorectal cancer30.2MTHFR
21atherosclerosis30.2SERPINC1, SERPINE1, SULT1A3, NOS3, THBD, PLAT
22vascular disease30.2SERPINC1, SERPINE1, SULT1A3, NOS3, THBD, PLAT
23rheumatoid arthritis30.2F10, MTHFR, APOH
24leukemia30.2FGA, F10, MTHFR, F8
25factor v deficiency30.2F2, F5, F8
26thrombophlebitis30.1F8, APOH
27sickle cell disease30.1NOS3, FGA
28ovarian hyperstimulation syndrome30.1F5
29ovarian cancer30.1FGA
30amyloidosis30.1F10
31acute leukemia30.1FGA, MTHFR
32disseminated intravascular coagulation30.0SERPINC1, SERPINE1, THBD, PLAT, F2, FGA
33acute myocardial infarction30.0SERPINC1, SERPINE1, SULT1A3, THBD, PLAT, FGA
34ischemic heart disease30.0SERPINE1, NOS3, PLAT, FGA, F7, F10
35ischemia30.0NOS3, PLAT, FGA, F10
36coronary thrombosis30.0SERPINC1, SERPINE1, PLAT
37proteinuria30.0NOS3, FGA, APOH
38adenocarcinoma30.0THBD, HABP2, TNXA
39pancreatitis30.0SULT1A3
40endocarditis30.0F10
41stroke, ischemic30.0F2, F5
42intracranial aneurysm30.0NOS3
43factor xii deficiency30.0F5
44factor v leiden thrombophilia29.9SERPINC1, SERPINE1, THBD, PLAT, F2, P2RY12
45factor vii deficiency29.9SERPINC1, F2, F7, F10, F5, F8
46portal vein thrombosis29.9SERPINC1, F2, MTHFR, F5, F8
47factor xi deficiency29.9F2, F7, F5, F8
48homocystinuria29.9SERPINC1, MTHFR, F5
49placental abruption29.9SERPINC1, MTHFR, F5
50polycystic ovary syndrome29.9SERPINE1

Graphical network of the top 20 diseases related to Thromboembolism:



Diseases related to thromboembolism

Clinical Features for Thromboembolism

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Sources:
46OMIM
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Clinical features from OMIM:

188050

Clinical synopsis from OMIM:

188050

Drugs & Therapeutics for Thromboembolism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Thromboembolism

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Anatomical Context for Thromboembolism

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32MalaCards
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MalaCards organs/tissues related to Thromboembolism:

32
Lung

Animal Models for Thromboembolism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thromboembolism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.6SERPINC1, APOH, F8, F5, MTHFR, F10
2MP:001076811.6PROCR, F10, MTHFR, F5, F8, APOH
3MP:000539711.3F8, PROCR, PROC, FGA, P2RY12, F2
4MP:000538711.1F8, PROCR, PROC, FGA, F2, PLAT
5MP:000538510.9F10, F7, FGA, F2, NOS3
6MP:000538010.9PROCR, FGA, F2, THBD, NOS3, SERPINC1
7MP:000538910.8F8, MTHFR, F10, FGA, SERPINC1
8MP:000537010.8F5, PROC, FGA, THBD, NOS3, SERPINE1
9MP:000363110.7F5, MTHFR, PROC, FGA, F2, PLAT

Publications for Thromboembolism

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Genetic Variations for Thromboembolism

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Expression for genes affiliated with Thromboembolism

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thromboembolism

Search GEO for disease gene expression data for Thromboembolism.

Pathways for genes affiliated with Thromboembolism

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 51QIAGEN, 49PharmGKB, 12EMD Millipore
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Pathways related to Thromboembolism according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1SERPINC1, SERPINE1, THBD, PLAT, F2, FGA
2
Hide members
11.1FGA, F7, PROC, F10, F5, F8
3
Hide members
11.1F8, F5, F10, PROC, F7, FGA
4
Hide members
11.0F5, SERPINC1, THBD, F2, FGA, F7
5
Hide members
10.8FGA, P2RY12, F2, THBD, NOS3
610.8MTHFR, F7, F2, PLAT, SERPINE1
7
Hide members
10.8F8, F5, F10, PROC, F7
8
Hide members
10.7F8, F5, FGA, SERPINE1
910.7F2, F7, PROC, F10
10
Hide members
10.7F2, F7, PROC, F10
1110.7F2, P2RY12, FGA
12
Cell adhesion ECM remodeling
Hide members
10.7SERPINE1, PLAT, FGA
1310.7THBD, F2, PROC
1410.7PROC, F8, APOH
1510.6PLAT, SERPINE1

Compounds for genes affiliated with Thromboembolism

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 24HMDB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Thromboembolism according to GeneCards/GeneDecks:

(show top 50)    (show all 200)
idCompoundScoreTop Affiliating Genes
1fibrinogen4412.0TNXA, APOH, SERPINC1, SERPINE1, SULT1A3, THBD
2aspirin44 49 28 2414.8SERPINC1, SERPINE1, SULT1A3, NOS3, THBD, PLAT
3creatinine4411.7P2RY12, FGA, F7, MTHFR, F5, F8
4hirudin4411.6TNXA, F8, F5, F10, PROCR, FGA
5homocysteine44 2412.6MTHFR, F2, PLAT, THBD, NOS3, SULT1A3
6kininogen4411.5APOH, HABP2, SERPINC1, SERPINE1, THBD, PLAT
7argatroban44 1112.4F2, THBD, SERPINC1, PLAT, FGA, TNXA
8prostacyclin4411.4F8, SERPINC1, SERPINE1, NOS3, THBD, PLAT
9gamma-carboxyglutamic acid4411.4TNXA, F5, F10, PROCR, PROC, F7
10protamine4411.4SERPINC1, SERPINE1, PLAT, F2, FGA, F10
11ancrod4411.4F5, F10, FGA, F2, SERPINC1, SERPINE1
12bivalirudin44 1112.4F5, F10, FGA, F2, PLAT, THBD
13pge14411.4APOH, SERPINE1, THBD, PLAT, F2, P2RY12
14phospholipid4411.3F10, APOH, F5, TNXA, F2, THBD
15desmopressin44 59 28 1114.3THBD, F8, F5, F2, PLAT, SERPINE1
16fondaparinux4411.3TNXA, F5, F10, F2, PLAT, THBD
17aprotinin44 1112.3F10, SERPINC1, SERPINE1, THBD, PLAT, FGA
18clopidogrel49 44 11 2414.3P2RY12, SERPINC1, TNXA, F10, F2, PLAT
19endotoxin4411.3FGA, F8, F5, PROCR, SERPINE1, APOH
20cholesterol44 28 11 2414.3PLAT, THBD, SERPINE1, F5, FGA, F7
21dermatan sulfate4411.3THBD, PLAT, TNXA, F5, F10, F2
22heparin44 28 11 2414.3P2RY12, FGA, F10, MTHFR, F8, APOH
23Drotrecogin alfa1111.3F5, PROCR, F8, F2, THBD, SERPINE1
24ppack4411.2PLAT, P2RY12, SERPINC1, F2, FGA, F10
25serine4411.2FGA, F7, PROCR, F10, F8
26hirugen4411.2F5, SERPINC1, F2, THBD, FGA
27warfarin44 49 11 2414.2SERPINC1, APOH, PROC, FGA
28spectrozyme4411.2SERPINC1, PLAT, F2, F10, F5
29batroxobin4411.1SERPINE1, PLAT, F2, F5, FGA
30fibrinopeptide a4411.1SERPINC1, THBD, PLAT, F2, FGA
31danaparoid4411.1F10, F2, TNXA, F5, SERPINC1
32ximelagatran44 1112.1F2, F10, THBD, SERPINC1, F5
33kaolin4411.1APOH, F2, F10, F8, F5
34heparinoids4411.1SERPINC1, THBD, F5, F10, F2
35phosphatidylethanolamine44 1112.1F8, HABP2, F5, PROCR, F2, APOH
36aspartate4411.1F2, F10, F8, SULT1A3, F7
3711-dehydrothromboxane b24411.1FGA, SERPINE1, THBD, F2, APOH
38citrate4411.1F2, NOS3, F8, F10, F5, SERPINC1
39protamine sulfate4411.1PLAT, SERPINC1, F2, F5, F10
40tranexamic acid44 1112.0F8, F2, PLAT, SERPINE1, SERPINC1
41tirofiban44 1112.0F2, F10, P2RY12, PLAT, SERPINC1
42cacl24411.0F5, F10, FGA, F8, THBD
43simvastatin44 49 59 28 11 2416.0PLAT, SERPINE1, THBD, NOS3, F10, F5
44ecarin4410.9F2, F5, F10, SERPINC1
45cardiolipin44 1111.8F10
46cyclophosphamide44 49 1112.8F8, MTHFR, F5, THBD, APOH, SERPINE1
47ristocetin4410.8F2, SERPINC1, PLAT, F5, F8
48levonorgestrel44 59 28 1113.8F5, SERPINC1, PLAT, F2, F7
49estrogen4410.8APOH, SULT1A3, F8
50ticlopidine44 1111.5FGA, APOH, PLAT, P2RY12, SERPINC1

GO Terms for genes affiliated with Thromboembolism

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16Gene Ontology
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Cellular components related to Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.2SERPINC1, HABP2, SERPINE1, PLAT, F2, FGA
2extracellular spaceGO:00561511.2PLAT, SERPINE1, F2, FGA, F7, F5
3plasma membraneGO:00588610.9P2RY12, F8, F5, F10, PROC, F7
4platelet alpha granule lumenGO:03109310.7F5, FGA, SERPINE1, F8
5endoplasmic reticulum lumenGO:00578810.7F10, PROC, F2, F7
6Golgi lumenGO:00579610.6F10, F7, F2, PROC

Biological processes related to Thromboembolism according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.6SERPINC1, F8, F5, F10, PROCR, PROC
2platelet activationGO:03016811.0SERPINE1, F2, P2RY12, FGA, F5, F8
3negative regulation of fibrinolysisGO:05191811.0APOH, F2, THBD, SERPINE1
4positive regulation of blood coagulationGO:03019411.0APOH, F7, F2, SERPINE1
5peptidyl-glutamic acid carboxylationGO:01718711.0F10, PROC, F7, F2
6negative regulation of blood coagulationGO:03019511.0APOH, PROC, THBD, SERPINE1
7blood coagulation, intrinsic pathwayGO:00759710.9APOH, F8, F10, F2
8proteolysisGO:00650810.9PLAT, F2, F7, PROC, F10, HABP2
9platelet degranulationGO:00257610.9SERPINE1, FGA, F5, F8
10negative regulation of platelet activationGO:01054410.8F2, THBD, NOS3
11fibrinolysisGO:04273010.8F2, PLAT, SERPINE1
12post-translational protein modificationGO:04368710.6F2, F7, PROC, F10
13negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.6SERPINE1, NOS3
14blood coagulation, extrinsic pathwayGO:00759810.6F10, F7
15plasminogen activationGO:03163910.3PLAT, APOH

Molecular functions related to Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0F2, FGA, PROC, PROCR, F10, F5
2serine-type endopeptidase activityGO:00425210.7PLAT, F2, F7, PROC, F10, HABP2
3receptor bindingGO:00510210.7F7, FGA, F2, SERPINE1

Products for genes affiliated with Thromboembolism

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  • Antibodies
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Sources for Thromboembolism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet