MCID: THR079
MIFTS: 64

Thromboembolism malady

Blood diseases category

Summaries for Thromboembolism

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Thrombosis (Greek: ?????????) is the formation of a blood clot (thrombus; Greek: ???????) inside a blood... more...

MalaCards: Thromboembolism is related to hypertension and patent foramen ovale. An important gene associated with Thromboembolism is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are Dissolution of Fibrin Clot and Cell surface interactions at the vascular wall. The drugs heparin and heparin sodium and the compounds hirugen and inogatran have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart, and related mouse phenotypes are liver/biliary system and embryogenesis.

Description from OMIM:48 188050

Aliases & Classifications for Thromboembolism

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48OMIM, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

thromboembolism 48 46 63


Related Diseases for Thromboembolism

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18GeneCards, 19GeneDecks
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Diseases related to Thromboembolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 349)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.6F2, SERPINE1, MTHFR, PLAT, F5
2patent foramen ovale30.6F5
3thrombophilia30.6PLAT, F2, THBD, MTHFR, F3, PROCR
4pulmonary embolism30.5F2, F5, PLAT, MTHFR, F3, SERPINC1
5protein s deficiency30.5F5, SERPINC1
6antithrombin iii deficiency30.4APOH, F10, F2, F5, MTHFR, SERPINC1
7protein c deficiency30.4PROCR, PROC, SERPINC1, SERPINE1, APOH, THBD
8hyperhomocysteinemia30.4F5, PLAT, MTHFR, SERPINC1, SERPINE1, APOH
9thrombocytopenia30.4F2, THBD, F10, APOH, SERPINC1, F3
10thrombophlebitis30.3APOH
11thrombocytosis30.3F2, THBD, F10, SERPINC1, F3
12myocardial infarction30.2SERPINC1, SERPINE1, F10, F5, PLAT, MTHFR
13lupus erythematosus30.2F2, THBD, APOH, SERPINC1, PROCR, F3
14endocarditis30.2F10
15factor xii deficiency30.2F5, F3
16vascular disease30.2THBD, APOH, SERPINC1, F3
17breast cancer30.1F10, SERPINE1, SULT1A3, PROCR, MTHFR, PLAT
18antiphospholipid syndrome30.1F5, PLAT, MTHFR, F3, PROCR, SULT1A3
19dysfibrinogenemia30.1F5, PLAT, SERPINC1, THBD, F2
20systemic lupus erythematosus30.1F2, THBD, F10, APOH, SULT1A3, PROCR
21coronary thrombosis30.1SERPINE1, SERPINC1, F3, PLAT
22placental abruption30.0SERPINC1, MTHFR, F5
23homocystinuria30.0F5, MTHFR, SERPINC1
24behcet's disease30.0F5, APOH, THBD
25factor xi deficiency30.0F2, F3, F5
26venous thrombosis30.0F5, PLAT, MTHFR, F3, PROCR, PROC
27portal vein thrombosis29.9F2, SERPINC1, MTHFR, F5
28retinal artery occlusion29.9APOH
29central retinal artery occlusion29.9PLAT
30atherosclerosis29.9APOH, THBD, HABP2, SERPINE1, SERPINC1, SULT1A3
31sagittal sinus thrombosis29.9SERPINC1, F5
32factor vii deficiency29.9F2, F10, SERPINC1, F3, F5
33homocysteinemia29.8MTHFR, F5
34eclampsia29.8THBD, SERPINC1, MTHFR
35cerebrovascular disease29.7APOH, MTHFR
36glanzmann's thrombasthenia29.7F10, F3
37factor v deficiency29.7F5, F3, F2
38disseminated intravascular coagulation29.7F5, PLAT, F3, PROC, SERPINC1, SERPINE1
39coronary artery disease29.7PLAT, SERPINE1, F10
40arteriosclerosis29.7MTHFR, SERPINE1
41peripheral vascular disease29.7THBD, F3, MTHFR, PLAT
42connective tissue disease29.7F3, APOH, THBD, F2
43acute myocardial infarction29.7THBD, F10, SERPINE1, SERPINC1, SULT1A3, F3
44liver cirrhosis29.6F2, F10, SERPINC1, F3
45congenital heart disease29.6F2, THBD, SERPINE1, F3, MTHFR
46sepsis29.5F5, F3, PROCR, PROC, SULT1A3, SERPINC1
47pre-eclampsia29.4F10, THBD, F2, APOH, SERPINE1, F5
48venous thromboembolism11.3
49chronic thromboembolic pulmonary hypertension11.1
50aneurysm10.5

Graphical network of the top 20 diseases related to Thromboembolism:



Diseases related to thromboembolism

Symptoms for Thromboembolism

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48OMIM
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Symptoms by clinical synopsis from OMIM:

188050

Clinical features from OMIM:

188050

Drugs & Therapeutics for Thromboembolism

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Thromboembolism

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Anatomical Context for Thromboembolism

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34MalaCards
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MalaCards organs/tissues related to Thromboembolism:

34
Lung, Testes, Heart, Endothelial, Brain, Breast, Liver, Kidney, Lymph node, Spinal cord, B cells, Monocytes, Ovary, Skin, Placenta, Prostate, Whole blood, Cervix, Smooth muscle, Spleen, Bone

Animal Models for Thromboembolism or affiliated genes

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38MGI
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Publications for Thromboembolism

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53PubMed
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Articles related to Thromboembolism:

(show top 50)    (show all 2026)
idTitleAuthorsYear
1
Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis. (24424839)
2014
2
Recent advances of pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension including Japanese experiences. (24068659)
2014
3
Adherence With Postdischarge Venous Thromboembolism Chemoprophylaxis Recommendations After Colorectal Cancer Surgery Among Elderly Medicare Beneficiaries. (24169191)
2013
4
Saddle pulmonary thromboembolism. (24222701)
2013
5
Comparing clinical predictors of deep venous thrombosis versus pulmonary embolus after severe injury: a new paradigm for posttraumatic venous thromboembolism? (23609272)
2013
6
Balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension. (23846611)
2013
7
Is tamoxifen associated with an increased risk for thromboembolic complications in patients undergoing microvascular breast reconstruction? (23423877)
2013
8
Prolonged outpatient vitamin K antagonist use and risk of venous thromboembolism in patients undergoing total hip or knee replacement. (23387806)
2013
9
Commentary on "Venous Thromboembolism After Face-Lift Surgery Using Local Anesthesia: Results of a Multicenter Survey" (24149626)
2013
10
Intermittent pneumatic compression is effective in reducing venous thromboembolism risk in hospitalised patients. (24361752)
2013
11
Neonatal systemic thromboembolism secondary to ductus arteriosus aneurysm and patent foramen ovale. (21801317)
2013
12
Risk of recurrence of unusual site venous thromboembolism. (23756963)
2013
13
Clinical outcomes of thromboendarterectomy for chronic thromboembolic pulmonary hypertension: 12-year experience. (23423163)
2013
14
Venous thromboembolism prevention in pediatric trauma-time for national guidelines. (24173133)
2013
15
Risk factors for pregnancy-associated venous thromboembolism: a review. (24334422)
2013
16
Validation of the clinical prediction rule for recurrent venous thromboembolism in cancer patients: the Ottawa score. (23525939)
2013
17
Management of venous thromboembolism--controversies and the future. (23531017)
2013
18
Educational outreach visits to improve nurses' use of mechanical venous thromboembolism prevention in hospitalized medical patients. (24238096)
2013
19
Fatal venous thromboembolism associated with hospital admission: a cohort study to assess the impact of a national risk assessment target. (24038168)
2013
20
Evaluation of pharmacologic prophylaxis for venous thromboembolism in patients with chronic liver disease. (23553808)
2013
21
Myometrial cavernous hemangioma with pulmonary thromboembolism in a post-partum woman: a case report and review of the literature. (23176111)
2012
22
Influence of the factor II G20210A variant or the factor V G1691A mutation on symptomatic recurrent venous thromboembolism in children: an international multicenter cohort study. (18983482)
2009
23
Long-term outcome after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: a single institution experience. (19272789)
2009
24
Should patients with venous thromboembolism be screened for thrombophilia? (18501222)
2008
25
Dose-escalation study of rivaroxaban (BAY 59-7939)--an oral, direct Factor Xa inhibitor--for the prevention of venous thromboembolism in patients undergoing total hip replacement. (17292948)
2007
26
The risk for thromboembolic disease in lupus anticoagulant patients due to pathways involving P-selectin and CD154. (17393020)
2007
27
Thromboendarterectomy for severe chronic thromboembolic pulmonary hypertension. (17540993)
2007
28
Study on the relationship between polymorphisms of susceptible genes in coagulation pathway related to pulmonary thromboembolism in Chinese Han population]. (16750002)
2006
29
Effects of pulmonary thromboendarterectomy on right-sided echocardiographic parameters in patients with chronic thromboembolic pulmonary hypertension. (16770978)
2006
30
Factor V Leiden as a common genetic risk factor for venous thromboembolism. (16579319)
2006
31
Haptoglobin phenotype 2-2 as a potentially new risk factor for spontaneous venous thromboembolism. (16266904)
2005
32
Challenges in the prevention of venous thromboembolism in the elderly. (15304033)
2004
33
Risk of venous thromboembolism during pregnancy in homozygous carriers of the factor V Leiden mutation: are there any predictive factors? (14996015)
2004
34
A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism. (15297315)
2004
35
Combined protein C and protein S deficiency in a family with repetitive thromboembolism and segregated gene mutations. (12705793)
2003
36
The risk of venous thromboembolism associated with the factor V Leiden mutation and low B-vitamin status. (14580166)
2003
37
Pregnancy-associated venous thromboembolism (VTE) in combined heterozygous factor V Leiden (FVL) and prothrombin (FII) 20210 A mutation and in heterozygous FII single gene mutation alone. (14531916)
2003
38
Thromboembolism after ovarian stimulation: successful management of a woman with superior sagittal sinus thrombosis after IVF and embryo transfer: case report. (14585890)
2003
39
Clinical study of venous thromboembolism during pregnancy and puerperium. (11372769)
2001
40
Prevalence of factor V Leiden and prothrombin 20210 A variant in Bulgarian patients with pulmonary thromboembolism and deep venous thrombosis. (11734663)
2001
41
Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis. (11071624)
2000
42
Surgical treatment of chronic thromboembolic pulmonary hypertension. (10700671)
2000
43
Extended anticoagulation for prevention of recurrent venous thromboembolism in carriers of factor V Leiden--cost-effectiveness analysis. (11127850)
2000
44
Increased lipoprotein(a) is an important risk factor for venous thromboembolism in childhood. (10449697)
1999
45
Prevalence of the factor VLeiden mutation among autopsy patients with pulmonary thromboembolic disease using an improved method for factor VLeiden detection. (10078118)
1999
46
Surgical treatment for chronic thromboembolic pulmonary hypertension under profound hypothermia and circulatory arrest in 24 patients. (10875595)
1999
47
Activated protein C resistance and deficiencies of antithrombin III, protein C or protein S and the risk of thromboembolic disease in users of oral contraceptives. (9710709)
1998
48
Recurrent venous thromboembolic disease and factor XI concentrate in a patient with severe factor XI deficiency, chronic myelomonocytic leukaemia, factor V Leiden and heterozygous plasminogen deficiency. (9391725)
1997
49
Platelet thromboembolism. (8013531)
1994
50
Etiology and pathogenesis of spontaneous venous thromboembolism]. (8273075)
1993

Variations for Thromboembolism

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Thromboembolism:

1
id Gene Name Type Significance SNP ID Assembly Location
1F2NM_000506.3(F2): c.*97G> Asingle nucleotide variantPathogenic, association, risk factorrs1799963GRCh37Chr 11, 46761055: 46761055
2F2NM_000506.3(F2): c.1787G> T (p.Arg596Leu)single nucleotide variantPathogenic, Uncertain significancers387907201GRCh37Chr 11, 46760876: 46760876

Expression for genes affiliated with Thromboembolism

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thromboembolism

Search GEO for disease gene expression data for Thromboembolism.

Pathways for genes affiliated with Thromboembolism

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 52PharmGKB, 31KEGG, 54QIAGEN, 55R&D Systems
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Pathways related to Thromboembolism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PLAT, SERPINE1
2
Show member pathways
9.0PROC, F2, THBD
3
Show member pathways
thioredoxin pathway39
8.9MTHFR, PLAT, SERPINE1, F2
4
Show member pathways
8.9F2, F10, PROC
5
Show member pathways
8.1F10, F2, PROC, SULT1A3
6
Show member pathways
7.5F10, SERPINC1, F5, PROC, THBD, F2
7
Show member pathways
6.7F5, PLAT, F3, PROC, SERPINC1, SERPINE1
8
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
6.7THBD, F10, SERPINC1, PROC, F3, PLAT
9
Show member pathways
6.7F5, SERPINC1, F3, PROC, SERPINE1, F10

Compounds for genes affiliated with Thromboembolism

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 52PharmGKB, 25HMDB
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Compounds related to Thromboembolism according to GeneCards/GeneDecks:

(show top 50)    (show all 205)
idCompoundScoreTop Affiliating Genes
1hirugen469.3F5, SERPINC1, THBD, F2
2inogatran469.2F2, SERPINC1, F3, F5
3efegatran469.1F10, SERPINC1, F3, PLAT
4fibrinopeptide a469.0F2, THBD, SERPINC1, PLAT
5batroxobin469.0F2, SERPINE1, PLAT, F5
6heparin sodium469.0F2, THBD, F3, PLAT
7ecarin468.9F2, F10, SERPINC1, F3, F5
8danaparoid468.8F2, F10, SERPINC1, F3, F5
9kaolin468.8F2, F10, APOH, F3, F5
10coumarins468.7F2, F10, APOH, F3, F5
11ristocetin468.7F2, SERPINC1, F3, PLAT, F5
12tranexamic acid46 129.7F2, SERPINE1, SERPINC1, F3, PLAT
13organon468.7F2, F10, SERPINC1, F3
14p-amino benzamidine468.7F10, SERPINE1, SERPINC1, PLAT
15dextran sulfate468.7HABP2, F10, APOH, SERPINC1, F3, F5
16levonorgestrel46 62 30 1211.6F2, SERPINC1, F3, PLAT, F5
17ppack468.6F2, F10, SERPINC1, F3, PLAT
18epsilon aminocaproic acid468.6F2, SERPINE1, SERPINC1, F3, PLAT
19tirofiban46 129.6F2, F10, SERPINC1, F3, PLAT
20rivaroxaban46 129.6F10, SERPINC1, F3, F2
21heparinoids468.5F2, THBD, F10, SERPINC1, F3, F5
22ximelagatran46 129.5F5, F2, THBD, F10, SERPINC1, F3
23pge1468.5F2, THBD, APOH, SERPINE1, PLAT, F5
24spectrozyme468.4F10, SERPINC1, F3, PLAT, F5, F2
25protamine sulfate468.4F2, F10, SERPINC1, F3, PLAT, F5
26abciximab46 129.4F2, F10, SERPINC1, F3, PLAT
27coumarin46 3 52 2511.4F2, F10, SERPINC1, F3, F5
28cardiolipin46 129.4F2, THBD, F10, APOH, F3, F5
29ancrod468.3F2, THBD, F10, SERPINE1, SERPINC1, PLAT
30prostacyclin468.3THBD, APOH, SERPINE1, SERPINC1, F3, PLAT
31desmopressin46 62 30 1211.2F2, THBD, SERPINE1, SERPINC1, F3, PLAT
32bivalirudin46 129.1F2, THBD, F10, SERPINC1, F3, PLAT
33argatroban46 129.1F5, PLAT, F2, THBD, F10, SERPINC1
34dermatan sulfate468.1THBD, F10, SERPINC1, F3, PLAT, F5
35fondaparinux468.1PLAT, F5, F3, SERPINC1, F2, THBD
36protamine468.1F5, F2, F10, SERPINE1, SERPINC1, F3
37gamma-carboxyglutamic acid467.9F10, PROC, PROCR, F3, F5, THBD
38simvastatin46 52 62 30 25 1212.9F2, THBD, F10, SERPINE1, F3, PLAT
39aprotinin46 128.7F2, THBD, F10, SERPINE1, SERPINC1, F3
40kininogen467.5F5, PLAT, F2, HABP2, THBD, APOH
41phospholipid467.5F2, THBD, F10, APOH, PROC, PROCR
42hirudin467.4F2, THBD, F10, SERPINE1, SERPINC1, PROCR
43warfarin46 52 25 129.9SERPINC1, PROC, F3, MTHFR, PLAT, F5
44aspartate466.9F2, THBD, F10, SERPINE1, SULT1A3, F3
45homocysteine46 257.8F2, THBD, APOH, SERPINE1, SERPINC1, SULT1A3
46creatinine466.8SERPINC1, SULT1A3, F3, MTHFR, PLAT, F5
47aspirin46 52 30 259.3SULT1A3, F3, MTHFR, PLAT, F5, SERPINC1
48serine466.2F2, HABP2, THBD, F10, SERPINE1, SERPINC1
49heparin46 30 25 128.4F2, HABP2, THBD, F10, APOH, SERPINE1
50fibrinogen465.1APOH, SERPINE1, SERPINC1, SULT1A3, PROC, PROCR

GO Terms for genes affiliated with Thromboembolism

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17Gene Ontology
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Cellular components related to Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic component of external side of plasma membraneGO:0312339.6F3, F10
2extracellular matrixGO:0310129.0APOH, SERPINE1, F3, PLAT
3Golgi lumenGO:0057968.9F2, F10, PROC
4endoplasmic reticulum lumenGO:0057888.9PROC, F10, F2
5cell surfaceGO:0099868.6THBD, APOH, F3, PLAT
6extracellular regionGO:0055767.4F2, HABP2, F10, SERPINE1, SERPINC1, PROC
7extracellular spaceGO:0056157.3F5, F2, HABP2, THBD, APOH, SERPINE1
8plasma membraneGO:0058867.0F2, THBD, F10, SERPINE1, SERPINC1, PROC

Biological processes related to Thromboembolism according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:0316399.9PLAT, APOH
2negative regulation of platelet activationGO:0105449.7F2, THBD
3blood coagulation, extrinsic pathwayGO:0075989.6F3, F10
4positive regulation of blood coagulationGO:0301949.5SERPINE1, APOH, F2
5negative regulation of proteolysisGO:0458619.4PLAT, F2
6fibrinolysisGO:0427309.4F2, SERPINE1, PLAT
7blood coagulation, intrinsic pathwayGO:0075979.4F2, F10, APOH
8platelet activationGO:0301689.3F5, SERPINE1, F2
9negative regulation of fibrinolysisGO:0519189.2F2, THBD, APOH, SERPINE1
10peptidyl-glutamic acid carboxylationGO:0171879.1F2, F10, PROC
11negative regulation of blood coagulationGO:0301959.1PROC, SERPINE1, APOH, THBD
12leukocyte migrationGO:0509009.0PROC, THBD, F2
13proteolysisGO:0065088.6F2, F10, PROC, PLAT
14post-translational protein modificationGO:0436878.6F2, F10, PROC
15blood coagulationGO:0075966.7F5, F2, THBD, F10, SERPINE1, SERPINC1

Molecular functions related to Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.2SERPINE1, SERPINC1, F3
2phospholipid bindingGO:0055438.9F3, APOH, F10
3calcium ion bindingGO:0055098.5PROC, F10, THBD, F2
4serine-type endopeptidase activityGO:0042528.0F5, F2, HABP2, F10, PROC, PLAT
5protein bindingGO:0055156.1F2, THBD, F10, APOH, SERPINE1, SERPINC1

Products for genes affiliated with Thromboembolism

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thromboembolism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet