Thrombophilia malady

Wikipedia: Thrombophilia (sometimes hypercoagulability or a prothrombotic state) is an abnormality of blood...⁴⁴ more...

MalaCards: Thrombophilia, also known as thrombophilia (disorder), is related to thrombosis and thromboembolism. An important gene associated with Thrombophilia is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Common Pathway and Cell adhesion_Plasmin signaling. The compounds Drotrecogin alfa and tranexamic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, small intestine and kidney, and related mouse phenotypes are hematopoietic system and embryogenesis.

Aliases & Descriptions:

thrombophilia 6 7 17 8 32 43 thrombophilia (disorder) 6 16

hypercoagulability state (finding) 6

Diseases related to thrombophilia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 537)

id	Related Disease	Score	Top Affiliating Genes
1	thrombosis	35.5	SERPINA10, MTHFR, FGB, F8, F5, F2
2	thromboembolism	33.7	MTHFR, HABP2
3	hyperprothrombinemia	30.5	SERPINC1, F2, CPB2
4	antiphospholipid syndrome	30.3	APOH, F2
5	factor v leiden thrombophilia	30.1	VWF, SERPINC1, SERPINF2, SERPINE1, ITGB3, ANXA5
6	protein s deficiency	30.0	PIGA, SERPINC1, CETP, F9, F5
7	thrombophilia, dysfibrinogenemic	29.8	FGB, FGG
8	venous thrombosis	29.8	VWF, SELP, SERPINC1, SERPINF2, SERPINA10, SERPINE1
9	thrombophilia, x-linked, due to factor ix defect	29.7	F9, EMB
10	thrombophilia due to protein s deficiency	29.5	PROS1, PROSP
11	myocardial infarction	29.4	APOB, APOE, ACE, THBD
12	placental abruption	29.3	SERPINC1, MTHFR, F5
13	amaurosis fugax	29.3	SERPINE1, MTHFR, APOH, F5
14	inflammatory bowel disease	29.2	SELE, SELP, JAK2, F5, F2R, F13A1
15	ovarian hyperstimulation syndrome	29.2	SERPINC1, MTHFR, APOH, F5, F3, F2
16	protein c deficiency	29.1	SERPINC1, SERPINF2, SERPIND1, SERPINA10, SERPINE1, MTHFR
17	essential thrombocythemia	28.6	VWF, SELP, JAK2, PPBP, PF4, THBD
18	central retinal vein occlusion	28.4	VWF, SERPINC1, SERPINE1, MTHFR, JAK2, APOH
19	porencephaly	27.9	MTHFR, F5, F2
20	intracranial hypertension	27.9	SERPINC1, SERPINE1, APOH, F5
21	legg-calve-perthes disease	27.7	SERPINC1, SERPINE1, F5, COL2A1, THBD
22	pulmonary embolism	27.6	SERPINC1, SERPINF2, SERPINE1, MTHFR, FGA, FGB
23	retinal vascular occlusion	27.5	PIGA, SELP, SERPINC1, MTHFR, APOH, F5
24	patent foramen ovale	27.5	SERPINC1, MTHFR, FGA, APOH, F5, F2
25	neural tube defect	27.4	MTRR, MTHFR, MTHFD1, CBS
26	retinal vein occlusion	27.4	VWF, SERPINC1, SERPINE1, MTHFR, JAK2, ITGB3
27	osteonecrosis	27.4	VWF, SERPINC1, SERPINE1, MTHFR, APOB, APOH
28	dysfibrinogenemia	27.3	SERPINC1, SERPIND1, FGA, FGB, FGG, F5
29	hypofibrinogenemia	27.3	VWF, SERPINC1, SERPINF2, SERPINE1, FGA, FGB
30	arterial occlusive disease	27.2	VWF, SELE, SELP, MTHFR, F3, CBS
31	gaucher's disease	27.2	MTHFR, F9, F5, F2, F2R, COL2A1
32	portal vein thrombosis	26.9	SELP, SERPINC1, SERPINE1, MTHFR, JAK2, APOH
33	moyamoya disease	26.7	SERPINC1, F3, F2, NOS3
34	hemolytic-uremic syndrome	26.7	VWF, SELP, SERPINC1, SERPINE1, APOH, F8
35	sinusitis	26.1	VWF, SELP, SERPINC1, SERPINE1, MTHFR, GSTP1
36	retinal artery occlusion	26.0	SERPINC1, SERPINE1, MTHFR, ITGB3, APOH, F9
37	spontaneous abortion	25.6	SELP, SERPINC1, SERPINE1, MTHFR, ITGB3, APOH
38	deep vein thrombosis	25.5	VWF, SELP, SERPINC1, SERPINE1, MTRR, MTHFR
39	peripheral arterial occlusive disease	25.4	VWF, SELE, SELP, SERPINE1, FGA, F5
40	hellp syndrome	25.2	VWF, SERPINC1, SERPINE1, MTHFR, GSTP1, APOH
41	acute lymphoblastic leukemia	25.2	SERPINC1, MTHFR, JAK2, GSTP1, FGA, APOB
42	peripheral vascular disease	25.2	VWF, SELE, SELP, SERPINE1, CETP, APOB
43	thalassemia	25.1	VWF, SELE, SERPINC1, MTHFR, JAK2, APOH
44	thrombocytosis	24.8	VWF, SELP, SERPINC1, SERPINF2, MTHFR, JAK2
45	polycythemia vera	24.2	VWF, SELP, SERPINC1, SERPINE1, JAK2, ITGB3
46	polycythemia	24.0	VWF, SELP, SERPINC1, SERPINE1, JAK2, ITGB3
47	retinitis	23.8	PIGA, VWF, SELE, SELP, SERPINC1, SERPINE1
48	pre-eclampsia	23.7	VWF, SELE, SELP, SERPINC1, SERPINF2, SERPINE1
49	vascular disease	22.8	VWF, SELE, SELP, SERPINC1, SERPINE1, MTRR
50	purpura	22.4	VWF, SELE, SELP, SERPINC1, SERPINF2, SERPINE1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to thrombophilia:

²²

MGI Mouse Phenotypes related to thrombophilia:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.9	PIGA, SERPIND1, FGG, PROCR, NQO1, HRG
2	embryogenesis phenotype	MP:0005380	9.5	PROCR, COL2A1, CBS, F2, FGG, SERPINC1
3	reproductive system phenotype	MP:0005389	9.2	PTGS1, PLG, AGT, ZP1, HNF1A, F10
4	respiratory system phenotype	MP:0005388	9.2	CPB2, COL2A1, F13A1, F11, CBS, APOE
5	nervous system phenotype	MP:0003631	8.7	F11, F12, PLG, COL2A1, AGT, THBD
6	integument phenotype	MP:0010771	8.5	F2, CBS, PTGS1, CYP7A1, NQO1, PROS1
7	immune system phenotype	MP:0005387	8.5	CPB2, PROC, HFE, COL2A1, PLG, PLAT
8	liver/biliary system phenotype	MP:0005370	8.2	PROS1, SERPINC1, FGA, APOB, AGT, COL2A1
9	renal/urinary system phenotype	MP:0005367	7.9	PLG, NOS3, COL2A1, AGT, CPB2, PTGS1
10	vision/eye phenotype	MP:0005391	7.4	F2R, CBS, CYP7A1, PLAT, PLG, NOS3
11	tumorigenesis	MP:0002006	7.3	PTGS1, NQO1, PLG, ACE, CPB2, HP
12	digestive/alimentary phenotype	MP:0005381	7.2	CYP7A1, PLAT, PLG, NOS3, COL2A1, HFE
13	behavior/neurological phenotype	MP:0005386	6.1	PTGS1, CYP7A1, PLAT, NOS3, COL2A1, ACE
14	cardiovascular system phenotype	MP:0005385	4.8	PROZ, PROC, PROS1, THBD, AGT, ACE
15	growth/size phenotype	MP:0005378	4.6	F3, SELE, PIGA, SELP, SERPINE1, MTRR
16	mortality/aging	MP:0010768	2.9	PLAT, CYP7A1, PTGS1, TPO, HNF1A, HP
17	homeostasis/metabolism phenotype	MP:0005376	2.4	PROZ, TPO, HNF1A, HP, HRG, F13A1

Articles related to thrombophilia:

(show top 50)    (show all 417)

id	Title	Authors	Year	Affiliating Genes
1	Analysis of polymorphisms in genes (AGT, MTHFR, GPIII a, and GSTP1) associated with hypertension, thrombophilia and oxidative stress in Mestizo and Amerindian populations of MAcxico. (20592457)	JuA!rez-VelA!zquez R.... Coral-VA!zquez R.M.	2010	GSTP1, ITGB3, AGT
2	Genetic thrombophilia and markers of endothelial act ivation in patients with preeclampsia]. (20939248)	Rojas J.C.... Collados M.T.	2010	F2, F5, MTHFR
3	Prophylactic therapy with enoxaparin in children with acute lymphoblastic leukemia and inherited thrombophilia during L-asparaginase treatment. (20546854)	Harlev D.... Elhasid R.	2010	F2
4	Thrombophilia risk factors are associated with intrauterine foetal death and pregnancy-related venous thromboembolism. (19031171)	Hvas A.M.... Salvig J.D.	2009	F5
5	Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives. (19139080)	Lijfering W.M.... van der Meer J.	2009	F9, F2, SERPINC1
6	Ocular vascular thrombotic events: a diagnostic window to familial thrombophilia (compound factor V Leiden and prothrombin gene heterozygosity) and thrombosis. (18796459)	Glueck C.J.... Wang P.	2009	MTHFR
7	Amaurosis fugax caused by hereditary thrombophilia du e to mutation of gene. (19507653)	Titlic M.... Miric L.	2009	SERPINE1, MTHFR
8	Association of inherited thrombophilia with embryonic and postembryonic recurrent pregnancy loss. (19786941)	Ivanov P.D.... Popov J.D.	2009	F5
9	Sclerotherapy of varicose veins in patients with docu mented thrombophilia: a prospective controlled randomized study of 105 cases. (19620700)	Hamel-Desnos C.M.... Allaert F.A.	2009	F2, F5
10	Early pregnancy loss in celiac women: The role of genetic markers of thrombophilia. (19395327)	Ciacci C.... Castaldo G.	2009	SERPINE1, F2, ITGB3
11	Thrombophilia and unexplained pregnancy loss in Indian patients. (19004141)	Vora S.... Ghosh K.	2008	SERPINE1, PC, SERPINC1
12	Inheritance and perinatal consequences of inherited thrombophilia in Greece. (17963764)	Karakantza M.... Decavalas G.	2008	F2, F5, MTHFR
13	Hereditary and acquired thrombophilia in patients with upper extremity deep-vein thrombosis. Results from the MAISTHRO registry. (18766260)	Linnemann B.... Lindhoff-Last E.	2008	SERPINC1, F8
14	Thrombophilia differences in cerebral venous sinus and lower extremity deep venous thrombosis. (18285537)	Wysokinska E.M.... McBane R.D.	2008	F2, F5, APOH
15	Combined inherited thrombophilia and adverse pregnancy outcome. (18225686)	Androutsopoulos G.... Decavalas G.	2007	F2, F5, MTHFR
16	Fibrinogen Columbus: a novel gamma Gly200Val mutation causing hypofibrinogenemia in a family with associated thrombophilia. (17650452)	Davis R.L.... Brennan S.O.	2007	FGG
17	Type and location of venous thromboembolism in patients with factor V Leiden or prothrombin G20210A and in those with no thrombophilia. (17067362)	Martinelli I.... Mannucci P.M.	2007	F2, F5
18	Inherited thrombophilia and arterial diseases (17370730)	Robert-Ebadi H.... de Moerloose P.	2007	SERPINC1
19	Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. (16595080)	Wu O.... Greer I.	2006	F2, F5, MTHFR
20	Genetic thrombophilia in patients with VTE in eastern Mediterranean located tertiary care center; is it time to change the algorithm for thrombophilia work up decision making? (16683219)	Isma'eel H.... Arnaout M.S.	2006	F5, MTHFR
21	The relationship between pregnancy induced hypertension and congenital thrombophilia. (16883445)	Demir S.C.... Kokangul S.	2006	SERPINC1, F5
22	Thrombophilia and the risk for venous thromboembolism during pregnancy, delivery, and puerperium. (16962918)	Nelson S.M.... Greer I.A.	2006	SERPINC1, F5
23	Thrombophilia in children with cystic fibrosis. (15678507)	Balfour-Lynn I.M.... Davidson S.J.	2005	F2, SERPINC1, F5
24	Antiphospholipid syndrome in the structure of hematogenic thrombophilia in young and middle-aged patients with venous thrombosis (15989003)	Shostak N.A.... Kalashnikova E.A.	2005	SERPINC1, MTHFR
25	Genetic thrombophilias and preeclampsia: a meta-analysis. (15625161)	Lin J.... August P.	2005	F2, F5, MTHFR
26	Thrombophilia in pregnancy and its influence on venous thromboembolism and recurrent miscarriages (16171147)	Kempf Haber M.... Klimek M.	2005	F2, SERPINC1, F5
27	The optimal duration of secondary thromboprophylaxis in patients with venous thromboembolism. The importance of thrombophilia screening. (15773739)	Kyrle P.A.	2005	SERPINC1
28	Thrombophilia and thrombosis (16296580)	ObradoviA8 D.	2005	F5
29	Prevalence of thrombophilia in women with severe ovarian hyperstimulation syndrome and cost-effectiveness of screening. (15066453)	Fabregues F.... Balasch J.	2004	SERPINC1, F5, APOH
30	The PAI-1 gene 4G/5G polymorphism and deep vein thrombosis in patients with inherited thrombophilia. (14653439)	Sartori M.T.... Girolami A.	2003	SERPINE1
31	Risk factors of thromboembolism associated with pregnancy and the puerperium. Role of inherited and acquired thrombophilia (15027582)	Ducloy-Bouthors A.S.... Trillot N.	2003	SERPINC1
32	Inherited thrombophilia, pregnancy, and oral contraceptive use: clinical implications. (15199492)	de Stefano V.... Leone G.	2003	F5
33	Thrombophilia and immunological disorders in pregnancies as risk factors for small for gestational age infants. (11843372)	Verspyck E.... Borg J.Y.	2002	APOH
34	Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss. (12042290)	Carp H.... Inbal A.	2002	F2, F5, MTHFR
35	Mid-trimester severe intrauterine growth restriction is associated with a high prevalence of thrombophilia. (12504973)	Kupferminc M.J.... Ascher-Landsberg J.	2002	F5
36	Thrombophilia is common in women with idiopathic preg nancy loss and is associated with late pregnancy wastage. (11821094)	Sarig G.... Brenner B.	2002	SERPINC1, F5
37	Diagnosis of thrombophilia (11446062)	Kemkes-Matthes B.	2001	SERPINC1, F5
38	Multicentre evaluation of combined prothrombotic defects associated with thrombophilia in childhood. Childhood Thrombophilia Study Group. (10650845)	Ehrenforth S.... Nowak-Gottl U.	1999	F2, SERPINC1, HRG
39	Congenital thrombophilia and thrombosis: a study in a single centre. (10490533)	Lawson S.E.... Williams M.D.	1999	SERPINC1, F5
40	Perinatal aspects of inherited thrombophilia. (10625206)	Bonnar J.... Norris L.	1999	SERPINC1, F5
41	Prothrombin G20210A gene mutation and further prothrombotic risk factors in childhood thrombophilia. (10521389)	Junker R.... Nowak-GAPttl U.	1999	F2, SERPINC1
42	Prevalence of factor V Leiden (APCR) and other inherited thrombophilias in young patients with myocardial infarction and normal coronary arteries. (9875108)	DaCosta A.... Guyotat D.	1998	SERPINC1, F5
43	Laboratory diagnosis of hereditary thrombophilia. (9763348)	Michiels J.J.... HamulyA!k K.	1998	F5
44	Thrombophilia and activated protein C resistance. (9841693)	Selzman C.H.... Krupski W.C.	1998	F5
45	Thrombophilia and fetal loss. (9242990)	Brenner B.... Blumenfeld Z.	1997	F5
46	Thrombophilia found in patients with moyamoya disease. (9409444)	Tsuda H.... Hamasaki N.	1997	SERPINC1
47	Thrombophilia, hypofibrinolysis, and alveolar osteonecrosis of the jaws. (8734702)	Glueck C.J.... Rabinovich B.	1996	F5
48	Significance of hereditary thrombophilia for risk of thrombosis with oral contraceptives (8701622)	Bauersachs R.... Kuhl H.	1996	SERPINC1
49	Thrombophilia associated with obesity in ethnic Chinese. (8589771)	Chan P.... Lee Y.H.	1995	SERPINC1, F3
50	Inherited thrombophilia (7998473)	Lopaciuk S.	1994	F5

Genes related to thrombophilia according to GeneCards:

(show top 50)    (show all 70)

id	Symbol	Description	Score	GeneCards Section Context
1	F5	coagulation factor V (proaccelerin, labile factor)	11.1	Publications, Summaries
2	PROC	protein C (inactivator of coagulation factors Va and VIIIa)	11.1	Summaries, Publications
3	HRG	histidine-rich glycoprotein	11.1	Summaries, Publications
4	PLG	plasminogen	11.1	Summaries
5	FGG	fibrinogen gamma chain	11.1	Summaries, Publications
6	PROS1	protein S (alpha)	11.1	Publications, Summaries
7	THBD	thrombomodulin	11.1	Publications, Summaries
8	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.1	Publications, Summaries
9	F2	coagulation factor II (thrombin)	11.0	Publications
10	F9	coagulation factor IX	11.0	Publications
11	PLAT	plasminogen activator, tissue	11.0	Publications
12	SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	11.0	Publications
13	EMB	embigin	11.0
14	FGB	fibrinogen beta chain	11.0	Publications
15	PROSP	protein S pseudogene (beta)	11.0
16	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
17	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
18	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
19	PROCR	protein C receptor, endothelial	11.0	Publications
20	SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	11.0	Publications
21	TNXA	tenascin XA (pseudogene)	11.0
22	CBS	cystathionine-beta-synthase	11.0	Publications
23	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	11.0	Publications
24	F12	coagulation factor XII (Hageman factor)	11.0
25	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
26	PF4	platelet factor 4	11.0	Publications
27	FGA	fibrinogen alpha chain	11.0	Publications
28	F13A1	coagulation factor XIII, A1 polypeptide	11.0	Publications
29	F7	coagulation factor VII (serum prothrombin conversion accelerator)	11.0	Publications
30	F11	coagulation factor XI	11.0
31	F8	coagulation factor VIII, procoagulant component	11.0	Publications
32	TAT	tyrosine aminotransferase	11.0
33	F2R	coagulation factor II (thrombin) receptor	11.0
34	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
35	ADAMTSL1	ADAMTS-like 1	11.0	Publications
36	ANXA5	annexin A5	11.0	Publications
37	VWF	von Willebrand factor	11.0	Publications
38	F10	coagulation factor X	11.0
39	SELE	selectin E	11.0
40	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0
41	ZP1	zona pellucida glycoprotein 1 (sperm receptor)	11.0	Publications
42	PROZ	protein Z, vitamin K-dependent plasma glycoprotein	11.0	Publications
43	CPB2	carboxypeptidase B2 (plasma)	11.0	Publications
44	CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	11.0	Publications
45	FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	11.0	Publications
46	HPR	haptoglobin-related protein	11.0
47	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	11.0	Publications
48	PIGA	phosphatidylinositol glycan anchor biosynthesis, class A	11.0
49	PC	pyruvate carboxylase	11.0	Publications
50	MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	11.0	Publications

Pathways related to thrombophilia according to GeneDecks:

(show all 21)

id	Pathway	Score	Top Affiliating Genes
1	Common Pathway38	10.4	SERPINC1, F5, F13A1
2	Cell adhesion_Plasmin signaling41	10.3	PLG, PLAT, F12, FGG, FGB, FGA
3	Cell adhesion Plasmin signaling10	10.3	PLG, PLAT, F12, FGG, FGB, FGA
4	Gamma-carboxylation of protein precursors38	10.3	F9, F10
5	Warfarin Pathway, Pharmacodynamics34	10.3	PROZ, PROC, PROS1, F10, F2, F7
6	Platelet activation, signaling and aggregation38	10.3	PF4, PLG, PPBP, FGG, FGB, FGA
7	Cell surface interactions at the vascular wall38	10.2	PROC, THBD, F2, ITGA3, SELP
8	Antimetabolite Pathway - Folate Cycle, Pharmacodynamics34	10.2	CBS, MTHFD1, MTHFR, MTRR
9	Methotrexate Pathway (Cancer Cell), Pharmacodynamics34	10.0	CBS, MTHFD1, MTHFR, MTRR
10	Cell adhesion Integrin inside-out signaling10	10.0	COL2A1, F2R, F2, FGG, FGB, FGA
11	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics34	9.9	CBS, MTHFD1, MTHFR, MTRR
12	Extrinsic Prothrombin Activation Pathway36	9.9	F7, F5, F3, F2, F10, F12
13	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	9.8	PTGS1, F2R, F2, FGG, FGB, FGA
14	Cell adhesion_Integrin inside-out signaling41	9.8	AGT, COL2A1, F2R, FGG, FGB, FGA
15	Selected targets of HNF110	9.7	PROC, HNF1A, F13A1, F8, APOH, APOB
16	Intrinsic Prothrombin Activation Pathway36	9.6	SERPINC1, FGA, FGB, FGG, F9, F8
17	Selected targets of C/EBPalpha10	9.6	SERPINC1, CETP, APOB, F9
18	Blood Coagulation Cascade36	9.4	FGA, COL2A1, THBD, PROS1, PROC, F13A1
19	Blood Coagulation Signaling Pathways37	9.4	F10, F11, F12, F13A1, PLAT, PLG
20	UPA-UPAR Pathway36	9.3	COL2A1, PLG, ITGB3, ITGA3, JAK2, SERPINE1
21	Complement and coagulation cascades20	9.0	VWF, F2, F2R, F10, F11, F12

Compounds related to thrombophilia according to GeneDecks:

(show top 50)    (show all 339)

id	Compound	Score	Top Affiliating Genes
1	Drotrecogin alfa9 9	11.4	PROCR, PROS1, THBD, PF4, F2, F5
2	tranexamic acid32 9 9	12.4	F9, SERPINE1, SERPINC1, VWF, PLG, PLAT
3	ancrod32	10.4	THBD, PLAT, F10, F2, F5, FGA
4	kaolin32	10.3	APOH, F9, F8, F5, F12, F10
5	fondaparinux32	10.2	F5, F9, SERPINC1, F3, F2, F10
6	abciximab32 9 9	12.2	F3, ANXA5, VWF, F2, F2R, F10
7	argatroban32 9 9	12.2	THBD, TNXA, F10, F2, F3, F5
8	hydroxyethyl starch32	10.1	OXA1L, F2, F3, F8, SERPINC1, SELE
9	gamma-carboxyglutamic acid32	10.1	PROCR, PROC, PROS1, THBD, PF4, TNXA
10	bivalirudin32 9 9	12.0	THBD, PLAT, TNXA, F10, F2R, F2
11	ppack32	10.0	VWF, SELP, SERPINC1, FGA, PLAT, F10
12	phosphatidylserine32 9 9	12.0	THBD, TNXA, F10, F2, F5, F9
13	hirudin32	10.0	F11, F10, F5, F9, FGB, FGA
14	ticlopidine32 9 9	11.8	VWF, SELP, PF4, PLAT, PPBP, PTGS1
15	iloprost32 42 9 9	12.8	THBD, PF4, PLAT, PPBP, PTGS1, F2R
16	ptca32	9.8	ADAMTSL1, THBD, AGT, PF4, PLAT, PPBP
17	11-dehydrothromboxane b232	9.7	THBD, PF4, PPBP, PTGS1, CBS, F2
18	protamine32	9.7	TNXA, F10, F2, F3, F5, FGA
19	thromboxane32 18	10.6	THBD, PF4, PLAT, PPBP, CYP7A1, PTGS1
20	tirofiban32 9 9	11.6	ADAMTSL1, PF4, PLAT, F10, F2R, F2
21	desmopressin32 42 9 9	12.5	PLAT, PPBP, PTGS1, F11, F2, F3
22	citrate32	9.5	SELP, PF4, NOS3, PPBP, HP, F10
23	lysine32	9.4	TAT, PF4, TNXA, TPO, F13A1, ANXA2
24	clopidogrel32 34 9 18 9	13.3	ACE, PPBP, PTGS1, TNXA, F10, F2R
25	dermatan sulfate32	9.3	TNXA, HRG, F11, F10, F2, F3
26	glutamate32	9.1	EMB, PC, MTRR, TAT, PLAT, F10
27	dextran sulfate32	8.4	HABP2, ADAMTSL1, PF4, F11, F10, F3
28	epinephrine32 9 18 9	11.2	SERPINF2, SELP, SELE, JAK2, FGA, APOB
29	phosphatidylcholine32	8.2	F10, F2, F5, F8, F9, ANXA2
30	atorvastatin32 34 9 18 9	12.1	CETP, SERPINE1, SELP, SELE, VWF, APOB
31	cysteine32	7.8	OXA1L, THBD, AGT, PF4, COL2A1, PLAT
32	lactate32	7.8	F2, F5, F8, ANXA5, APOH, APOB
33	adp32 18	8.8	F3, F8, F9, FGR, FGA, ITGB3
34	simvastatin32 34 42 9 18 9	12.7	THBD, AGT, NOS3, PLAT, F10, F2R
35	sodium dodecylsulfate32	7.5	VWF, SERPINF2, ADAMTSL1, OXA1L, NOS3, TPO
36	folate32	7.4	VWF, HP, CBS, F5, APOH, APOE
37	warfarin32 34 9 18 9	11.2	PROC, OXA1L, THBD, ACE, FGA, MTHFR
38	phospholipid32	7.2	ADAMTSL1, PROCR, PROC, PROS1, APOH, APOE
39	dexamethasone32 42 34 9 9	11.1	APOB, JAK2, SERPINE1, SERPINC1, SELP, PC
40	prostacyclin32	6.9	F8, APOH, APOE, FGA, SERPINE1, SERPINC1
41	heparin32 9 18 9	9.4	HABP2, F2R, F2, F3, F8, F9
42	arginine32	6.1	HRG, F10, CBS, F2R, F5, F8
43	nitric oxide32 9 18 9	8.9	F8, ANXA2, APOH, FGR, JAK2, MTRR
44	vegf32	5.2	PROS1, F8, ANXA2, ANXA5, APOH, APOE
45	fibrinogen32	5.1	ADAMTSL1, CPB2, PROCR, PROC, OXA1L, TAT
46	alanine32	5.0	HPR, CETP, MTHFR, MTRR, SERPINA10, SERPINF2
47	cholesterol32 9 18 9	7.8	PF4, PLAT, PPBP, CYP7A1, TPO, HNF1A
48	estrogen32	4.5	ADAMTSL1, TAT, THBD, HFE, NOS3, NQO1
49	lipid32	4.4	TPO, JAK2, CETP, SERPINE1, SERPINF2, SELE
50	serine32	2.9	TAT, F11, F10, CBS, F2R, F2

Cellular components related to thrombophilia according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	fibrinogen complex	GO:005577	10.4	FGG, FGB, FGA, SERPINF2
2	platelet alpha granule	GO:031091	10.2	FGG, FGB, FGA, VWF
3	Golgi lumen	GO:005796	10.1	PROZ, PROC, PROS1, F10, F2, F7
4	platelet alpha granule lumen	GO:031093	9.8	PROS1, PF4, PLG, PPBP, HRG, F13A1
5	extracellular matrix	GO:031012	9.8	PLAT, F3, ANXA2, APOH, SERPINE1, VWF
6	endoplasmic reticulum lumen	GO:005788	9.4	PROZ, PROC, COL2A1, F10, F2, F7
7	caveola	GO:005901	9.4	SELE, JAK2, F2R, NOS3
8	chylomicron	GO:042627	9.1	APOH, APOE, APOB
9	external side of plasma membrane	GO:009897	9.1	ACE, ANXA5, FGG, FGB, FGA, SELP
10	extracellular region	GO:005576	6.2	VWF, F2R, F2, F5, F7, F8
11	extracellular space	GO:005615	5.6	COL2A1, PLG, PLAT, PPBP, HP, F12
12	plasma membrane	GO:005886	4.9	HRG, F12, F11, F10, F2R, F2

Biological processes related to thrombophilia according to GeneDecks:

(show all 32)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of fibrinolysis	GO:051919	10.6	PLG, F12, F11
2	plasminogen activation	GO:031639	10.5	PLAT, F11, APOH
3	regulation of blood coagulation	GO:030193	10.5	F2, F2R, HRG
4	blood coagulation, extrinsic pathway	GO:007598	10.5	F10, F3, F7, F9
5	positive regulation of blood coagulation	GO:030194	10.4	F12, F2R, F2, F7, APOH, SERPINE1
6	blood vessel morphogenesis	GO:048514	10.4	SELP, SERPINF2, PLAT
7	negative regulation of fibrinolysis	GO:051918	10.4	SERPINF2, SERPINE1, APOH, F2, HRG, PLG
8	peptidyl-glutamic acid carboxylation	GO:017187	10.3	PROZ, PROC, PROS1, F10, F2, F7
9	methionine biosynthetic process	GO:009086	10.3	MTHFD1, MTHFR, MTRR
10	fibrinolysis	GO:042730	10.3	PROS1, CPB2, PLG, PLAT, SERPINF2, SERPINE1
11	positive regulation of platelet-derived growth factor receptor signaling pathway	GO:010641	10.3	F7, F3
12	response to reactive oxygen species	GO:000302	10.2	GSTP1, SERPINE1
13	blood coagulation, intrinsic pathway	GO:007597	10.2	F12, F11, F10, F2, F8, F9
14	negative regulation of blood coagulation	GO:030195	10.1	PROC, THBD, APOH, APOE, SERPINE1
15	post-translational protein modification	GO:043687	10.1	PROZ, PROC, PROS1, F10, F2, F7
16	positive regulation of cell migration	GO:030335	10.0	F10, F2R, F3, F7, FGR, JAK2
17	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.9	AGT, F2R, F2, FGR, JAK2, SELP
18	positive regulation of macrophage derived foam cell differentiation	GO:010744	9.8	AGT, PF4, APOB
19	leukocyte migration	GO:050900	9.7	PROC, PROS1, THBD, F2, APOB, ITGB3
20	cellular protein metabolic process	GO:044267	9.7	PROZ, PROC, PROS1, F10, F2, F7
21	low-density lipoprotein particle remodeling	GO:034374	9.7	CETP, APOB, AGT
22	platelet degranulation	GO:002576	9.6	SELP, SERPINF2, SERPINE1, ITGB3, FGA, FGB
23	response to lipopolysaccharide	GO:032496	9.6	THBD, F2R, F3, APOB, JAK2, SELP
24	negative regulation of platelet activation	GO:010544	9.6	THBD, NOS3, F2, APOE
25	platelet activation	GO:030168	9.5	FGG, PROS1, F8, F5, F2, F2R
26	regulation of renal output by angiotensin	GO:002019	9.1	ACE, AGT
27	cholesterol homeostasis	GO:042632	9.0	CYP7A1, APOE, APOB, CETP
28	blood vessel remodeling	GO:001974	9.0	AGT, ACE, NOS3, CBS
29	receptor-mediated endocytosis	GO:006898	8.9	CETP, APOB, APOE, HFE
30	proteolysis	GO:006508	8.6	ACE, PROS1, PROC, PROZ, CPB2, HABP2
31	blood coagulation	GO:007596	6.6	VWF, FGR, APOB, ANXA5, F9, F8
32	small molecule metabolic process	GO:044281	6.5	PTGS1, CYP7A1, NQO1, NOS3, AGT, TAT

Molecular functions related to thrombophilia according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	protease binding	GO:002020	10.3	F3, SERPINE1, SERPINF2, SERPINC1
2	oligosaccharide binding	GO:070492	10.2	SELE, SELP
3	cell surface binding	GO:043498	10.2	F3, HRG, PLG
4	eukaryotic cell surface binding	GO:043499	10.2	ANXA5, APOH, FGG, FGB, FGA, SERPINF2
5	glycoprotein binding	GO:001948	10.1	F7, APOH, SELP, VWF
6	immunoglobulin binding	GO:019865	10.0	VWF, HRG
7	receptor binding	GO:005102	9.9	F2R, F2, F7, FGG, FGB, FGA
8	serine-type endopeptidase activity	GO:004252	9.5	F9, HABP2, PROZ, PROC, PLG, PLAT
9	calcium ion binding	GO:005509	9.3	PROZ, PROC, PROS1, THBD, TPO, F10
10	heparin binding	GO:008201	9.2	PF4, HRG, F11, APOH, APOE, APOB
11	heme binding	GO:020037	8.9	NOS3, CYP7A1, PTGS1, TPO, HRG, CBS
12	protein binding	GO:005515	4.0	HNF1A, HRG, F12, F11, F10, CBS