MCID: THR053
MIFTS: 15

Thrombophilia, Dysfibrinogenemic malady

Blood diseases category

Summaries for Thrombophilia, Dysfibrinogenemic

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34MalaCards
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MalaCards: Thrombophilia, Dysfibrinogenemic is related to afibrinogenemia. An important gene associated with Thrombophilia, Dysfibrinogenemic is FGB (fibrinogen beta chain), and among its related pathways are Collagen biosynthesis and modifying enzymes and Cell adhesion ECM remodeling. The compounds fibrinogen and sucralfate have been mentioned in the context of this disorder.

Aliases & Classifications for Thrombophilia, Dysfibrinogenemic

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48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

thrombophilia, dysfibrinogenemic 48


Related Diseases for Thrombophilia, Dysfibrinogenemic

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Thrombophilia, Dysfibrinogenemic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1afibrinogenemia10.0FGB, FGG

Symptoms for Thrombophilia, Dysfibrinogenemic

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Drugs & Therapeutics for Thrombophilia, Dysfibrinogenemic

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Thrombophilia, Dysfibrinogenemic

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Genetic Tests for Thrombophilia, Dysfibrinogenemic

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Anatomical Context for Thrombophilia, Dysfibrinogenemic

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Animal Models for Thrombophilia, Dysfibrinogenemic or affiliated genes

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Publications for Thrombophilia, Dysfibrinogenemic

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Variations for Thrombophilia, Dysfibrinogenemic

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Expression for genes affiliated with Thrombophilia, Dysfibrinogenemic

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thrombophilia, Dysfibrinogenemic

Search GEO for disease gene expression data for Thrombophilia, Dysfibrinogenemic.

Pathways for genes affiliated with Thrombophilia, Dysfibrinogenemic

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Sources:
51PathCards, 56Reactome, 54QIAGEN, 61Thomson Reuters, 13EMD Millipore, 31KEGG, 39NCBI BioSystems Database, 55R&D Systems, 52PharmGKB
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Pathways related to Thrombophilia, Dysfibrinogenemic according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1FGB, FGG
2
Show member pathways
9.1FGG, FGB
3
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
9.1FGG, FGB
4
Show member pathways
9.1FGG, FGB
5
Show member pathways
9.1FGG, FGB
6
Show member pathways
9.1FGG, FGB
7
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.1FGB, FGG
8
Show member pathways
9.1FGG, FGB
99.1FGB, FGG
109.1FGB, FGG
119.1FGB, FGG
12
Show member pathways
9.1FGB, FGG

Compounds for genes affiliated with Thrombophilia, Dysfibrinogenemic

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Sources:
46Novoseek, 12DrugBank
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Compounds related to Thrombophilia, Dysfibrinogenemic according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1fibrinogen469.1FGB, FGG
2sucralfate46 1210.0FGB, FGG
3rsai468.8FGB, FGG

GO Terms for genes affiliated with Thrombophilia, Dysfibrinogenemic

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Sources:
17Gene Ontology
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Cellular components related to Thrombophilia, Dysfibrinogenemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:0055779.3FGB, FGG
2platelet alpha granuleGO:0310919.3FGB, FGG
3platelet alpha granule lumenGO:0310939.2FGB, FGG
4cell cortexGO:0059389.2FGB, FGG
5blood microparticleGO:0725629.1FGG, FGB
6extracellular spaceGO:0056159.1FGB, FGG
7external side of plasma membraneGO:0098979.0FGB, FGG
8cell surfaceGO:0099868.8FGB, FGG

Biological processes related to Thrombophilia, Dysfibrinogenemic according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein polymerizationGO:0512589.3FGB, FGG
2response to calcium ionGO:0515929.2FGB, FGG
3platelet degranulationGO:0025769.2FGB, FGG
4platelet activationGO:0301689.1FGG, FGB
5signal transductionGO:0071659.1FGB, FGG
6extracellular matrix organizationGO:0301989.0FGB, FGG
7blood coagulationGO:0075968.8FGB, FGG

Molecular functions related to Thrombophilia, Dysfibrinogenemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.1FGB, FGG
2protein binding, bridgingGO:0306748.8FGB, FGG

Products for genes affiliated with Thrombophilia, Dysfibrinogenemic

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thrombophilia, Dysfibrinogenemic

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet