MCID: THR053
MIFTS: 15

Thrombophilia, Dysfibrinogenemic malady

Blood diseases category
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Summaries for Thrombophilia, Dysfibrinogenemic

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33MalaCards
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MalaCards: Thrombophilia, Dysfibrinogenemic is related to afibrinogenemia. An important gene associated with Thrombophilia, Dysfibrinogenemic is FGB (fibrinogen beta chain), and among its related pathways are Collagen biosynthesis and modifying enzymes and Cell adhesion ECM remodeling. The compounds fibrinogen and sucralfate have been mentioned in the context of this disorder.

Aliases & Classifications for Thrombophilia, Dysfibrinogenemic

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47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

thrombophilia, dysfibrinogenemic 47


Related Diseases for Thrombophilia, Dysfibrinogenemic

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17GeneCards, 18GeneDecks
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Diseases related to Thrombophilia, Dysfibrinogenemic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1afibrinogenemia10.0FGB, FGG

Symptoms for Thrombophilia, Dysfibrinogenemic

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Drugs & Therapeutics for Thrombophilia, Dysfibrinogenemic

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Thrombophilia, Dysfibrinogenemic

Genetic Tests for Thrombophilia, Dysfibrinogenemic

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Anatomical Context for Thrombophilia, Dysfibrinogenemic

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Animal Models for Thrombophilia, Dysfibrinogenemic or affiliated genes

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Publications for Thrombophilia, Dysfibrinogenemic

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Variations for Thrombophilia, Dysfibrinogenemic

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Expression for genes affiliated with Thrombophilia, Dysfibrinogenemic

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thrombophilia, Dysfibrinogenemic

Search GEO for disease gene expression data for Thrombophilia, Dysfibrinogenemic.

Pathways for genes affiliated with Thrombophilia, Dysfibrinogenemic

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Sources:
50PathCards, 55Reactome, 53QIAGEN, 60Thomson Reuters, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 54R&D Systems, 51PharmGKB
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Pathways related to Thrombophilia, Dysfibrinogenemic according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1FGB, FGG
2
Show member pathways
9.1FGG, FGB
3
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.1FGG, FGB
4
Show member pathways
9.1FGG, FGB
5
Show member pathways
9.1FGG, FGB
6
Show member pathways
9.1FGG, FGB
7
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.1FGB, FGG
8
Show member pathways
9.1FGG, FGB
99.1FGB, FGG
109.1FGB, FGG
119.1FGB, FGG
12
Show member pathways
9.1FGB, FGG

Compounds for genes affiliated with Thrombophilia, Dysfibrinogenemic

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45Novoseek, 11DrugBank
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Compounds related to Thrombophilia, Dysfibrinogenemic according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1fibrinogen459.1FGB, FGG
2sucralfate45 1110.0FGB, FGG
3rsai458.8FGB, FGG

GO Terms for genes affiliated with Thrombophilia, Dysfibrinogenemic

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16Gene Ontology
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Cellular components related to Thrombophilia, Dysfibrinogenemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:0055779.3FGB, FGG
2platelet alpha granuleGO:0310919.3FGB, FGG
3platelet alpha granule lumenGO:0310939.2FGB, FGG
4cell cortexGO:0059389.2FGB, FGG
5blood microparticleGO:0725629.1FGG, FGB
6extracellular spaceGO:0056159.1FGB, FGG
7external side of plasma membraneGO:0098979.0FGB, FGG
8cell surfaceGO:0099868.8FGB, FGG

Biological processes related to Thrombophilia, Dysfibrinogenemic according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein polymerizationGO:0512589.3FGB, FGG
2response to calcium ionGO:0515929.2FGB, FGG
3platelet degranulationGO:0025769.2FGB, FGG
4platelet activationGO:0301689.1FGG, FGB
5signal transductionGO:0071659.1FGB, FGG
6extracellular matrix organizationGO:0301989.0FGB, FGG
7blood coagulationGO:0075968.8FGB, FGG

Molecular functions related to Thrombophilia, Dysfibrinogenemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.1FGB, FGG
2protein binding, bridgingGO:0306748.8FGB, FGG

Products for genes affiliated with Thrombophilia, Dysfibrinogenemic

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thrombophilia, Dysfibrinogenemic

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet