MCID: THR016
MIFTS: 69

Thrombophlebitis malady

Cardiovascular diseases, Blood diseases categories
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Summaries for Thrombophlebitis

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Wikipedia:65 Thrombophlebitis is phlebitis (vein inflammation) related to a thrombus (blood clot). When it occurs... more...

MalaCards based summary: Thrombophlebitis, also known as thrombophlebitis of superficial veins of lower extremity, is related to mondor disease and arteriovenous fistula. An important gene associated with Thrombophlebitis is APOH (apolipoprotein H (beta-2-glycoprotein I)), and among its related pathways are Glypican 1 network and Dissolution of Fibrin Clot. The drugs heparin and heparin sodium and the compounds inogatran and ecarin have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and liver, and related mouse phenotypes are liver/biliary system and muscle.

Disease Ontology:8 A phlebitis that results from a blood clot in the vessel.

Aliases & Classifications for Thrombophlebitis

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Thrombophlebitis, Aliases & Descriptions:

Name: Thrombophlebitis 8 44 62
Thrombophlebitis of Superficial Veins of Lower Extremity 8 62
Superficial Thrombophlebitis of Leg 8 62
 
Phlebitis and Thrombophlebitis of Superficial Vessels of Lower Extremities 8
Thrombophlebitis of a Superficial Leg Vein Nos 8
Thrombophlebitis Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Blood diseases


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Disease Ontology8 DOID:3875
NCIt39 C3410
MeSH34 D013924
ICD1025 I80.0

Related Diseases for Thrombophlebitis

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Diseases related to Thrombophlebitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1mondor disease31.0APOH, F5
2arteriovenous fistula30.7EPO
3purpura30.6SERPINC1
4factor xii deficiency30.4F5, F3
5mediastinitis30.2CRP
6behcet's disease30.1F5, APOH, CRP
7homocystinuria30.1SERPINC1, MTHFR, F5
8factor v deficiency30.0F5, F8, F3, F2
9dysfibrinogenemia29.8F2, SERPINC1, PLAT, F5
10protein c deficiency29.7F2, APOH, SERPINC1, PROC, PROS1, MTHFR
11pulmonary embolism29.6APOH, SERPINF2, SERPINC1, PROS1, F3, MTHFR
12leukemia29.6SERPINF2, EPO, TGFB1, MTHFR, F8
13sepsis29.6SERPINC1, PROC, F5, CRP, F3, F2
14lupus erythematosus29.6F2, APOH, SERPINC1, PROS1, F3, F5
15antithrombin iii deficiency29.5F5, MTHFR, PROS1, SERPINC1, APOH, F2
16systemic lupus erythematosus29.4F8, F3, CRP, F2, APOH
17protein s deficiency29.1F2, F5, F8, MTHFR, F3, PROS1
18venous thrombosis29.1F2, APOH, SERPINF2, SERPINC1, PROC, PROS1
19antiphospholipid syndrome29.1F2, APOH, SERPINC1, PROS1, F3, MTHFR
20thrombocytosis29.0SERPINF2, CRP, F3, EPO, SERPINC1, F2
21thromboembolism29.0PROC, F3, MTHFR, F8, PLAT, F5
22myocardial infarction28.8PLAT, SERPINF2, F3, MTHFR, F8, SERPINC1
23vascular disease28.8MTHFR, APOH, F5, CRP, F3, PLAT
24hypertension28.6TGFB1, F2, PROS1, CRP, MTHFR, PLAT
25thrombophilia28.3F2, APOH, SERPINF2, SERPINC1, PROC, PROS1
26thrombophlebitis migrans10.7
27retinal artery occlusion10.6APOH
28branch retinal artery occlusion10.6F5
29hepatic vein thrombosis10.5PROS1
30hypersplenism10.5F2
31cardiac tamponade10.5F8
32chickenpox10.5PROS1
33carotid artery thrombosis10.5F3
34sneddon syndrome10.4APOH, SERPINC1
35patent foramen ovale10.4F5
36central retinal artery occlusion10.4PLAT
37appendicitis10.4
38meningococcemia10.4SERPINC1, F5
39retinal vascular occlusion10.4F5, APOH
40combined factor v and viii deficiency10.4F8, F5
41post-thrombotic syndrome10.4SERPINC1, F5
42riboflavin deficiency10.4MTHFR
43legg-calve-perthes disease10.4F5, SERPINC1
44homocysteinemia10.4F5, MTHFR
45stroke, ischemic10.4F2, F5
46femoral vein thrombophlebitis10.4
47hemarthrosis10.3F8, F3
48cardiac rupture10.3PLAT
49eclampsia10.3SERPINC1, MTHFR
50cerebritis10.3

Graphical network of the top 20 diseases related to Thrombophlebitis:



Diseases related to thrombophlebitis

Symptoms for Thrombophlebitis

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Drugs & Therapeutics for Thrombophlebitis

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Genetic Tests for Thrombophlebitis

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Anatomical Context for Thrombophlebitis

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MalaCards organs/tissues related to Thrombophlebitis:

32
Lung, Breast, Liver, Myeloid, Bone, Brain, Retina, Colon, Pancreas, Skin, Placenta, Prostate, Testes, Endothelial, Tongue, Pituitary

Animal Models for Thrombophlebitis or affiliated genes

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Publications for Thrombophlebitis

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Articles related to Thrombophlebitis:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
Superficial abdominal thrombophlebitis (Mondor's disease) presenting as loss of response to adalimumab in a Crohn's disease patient. (24835166)
2014
2
Sporotrichoid eruption in a patient after lung transplantation. Scedosporium apiospermum fungal thrombophlebitis and sporotrichoid nodules. (24258488)
2014
3
Migratory superficial thrombophlebitis in a cannabis smoker. (25001627)
2014
4
Treatment of lower extremity superficial thrombophlebitis. (24549553)
2014
5
Septic thrombophlebitis of the superior mesenteric vein: an unusual complication of appendicitis. (23317599)
2013
6
Jugular thrombophlebitis in horses: a review of fibrinolysis, thrombus formation, and clinical management. (23814304)
2013
7
Treatment for superficial thrombophlebitis of the leg. (23633322)
2013
8
Candidal thrombophlebitis of central veins: case report and review. (21905947)
2012
9
Treatment of superficial thrombophlebitis. (21268737)
2011
10
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. (20881312)
2011
11
Complete visual recovery after mycotic aneurysm embolization complicated by cavernous sinus thrombophlebitis. (21052516)
2010
12
Title Page - thrombophlebitis - what else? (20703969)
2010
13
Postpartum ovarian vein thrombophlebitis: Report of a case and review of the literature. (22737678)
2010
14
Thrombolytic therapy for management of complicated catheter-related Candida albicans thrombophlebitis. (19290985)
2009
15
Extended septic thrombophlebitis in a patient with duplicated inferior vena cava: case report and review of literature. (19174747)
2009
16
Prevalence of deep vein thrombosis and pulmonary embolism in superficial thrombophlebitis of the lower limbs: prospective study of 60 cases. (19935595)
2009
17
Treating superficial venous thrombophlebitis. (18926088)
2008
18
Successful stem cell transplantation without cryopreservation from a microchimeric haploidentical sibling for refractory acute myeloid leukemia complicated with critical thrombophlebitis and cellulitis. (17261507)
2007
19
Clinical inquiries. What is the best therapy for superficial thrombophlebitis? (15251103)
2004
20
A hematogenic pleuropneumonia caused by postoperative septic thrombophlebitis in a Thoroughbred gelding. (15028889)
2004
21
Radiology quiz case 1. Childhood cavernous sinus thrombophlebitis. (15023852)
2004
22
Superior mesenteric thrombophlebitis subsequent to acute appendicitis in an adult. (12767025)
2003
23
Simultaneous ultrasound identification of acute appendicitis, septic thrombophlebitis of the portal vein and pyogenic liver abscess. (12916378)
2003
24
Superficial thrombophlebitis followed by pulmonary embolism. (11418716)
2001
25
Oropharyngeal Necrobacillosis with Septic Thrombophlebitis and Pulmonary Embolic Abscesses: Lemierre's Syndrome in a New Zealand White Rabbit. (12086416)
1999
26
Ultrasonographic investigation of the pathogenesis of infusion thrombophlebitis. (9171751)
1997
27
Thrombophlebitis and varicosis syndrome in pregnancy. (9107455)
1997
28
Septic thrombophlebitis of the inferior mesenteric vein associated with diverticulitis CT diagnosis. (8744820)
1996
29
Septic pelvic thrombophlebitis or refractory postpartum fever of undetermined etiology. (8972414)
1996
30
Suppurative thrombophlebitis. (7551490)
1995
31
Superficial thrombophlebitis of the breast (Mondor's disease): mammographic findings. (8498215)
1993
32
Development of thrombophlebitis in peripheral veins with Vialon and PTFE-Teflon cannulas: a double-blind, randomised, controlled trial. (1929137)
1991
33
Concurrent existence of heterotopic ossification and thrombophlebitis. (2106785)
1990
34
Deep vein thrombophlebitis of a leg in a young female with heterozygous protein C deficiency taking oral contraceptives. (1703114)
1990
35
Superficial migratory thrombophlebitis and factor XII deficiency. (2110579)
1990
36
Deep vein thrombophlebitis and pulmonary embolism in patients with malignant gliomas. (2814622)
1989
37
Infusion thrombophlebitis--histological and bacteriological study. (2628322)
1989
38
Obesity: is it really a risk factor in thrombophlebitis? (3310249)
1987
39
Puerperal pelvic thrombophlebitis: impact on diagnosis and treatment using x-ray computed tomography and magnetic resonance imaging. (3785791)
1986
40
Thrombophlebitis and septicemia--complications related to intravascular devices and their prophylaxis. A review. (3524089)
1986
41
Deep venous thrombosis, pulmonary embolism and acute surgery in thrombophlebitis of the long saphenous vein. (4013602)
1985
42
Calf hematoma mimicking thrombophlebitis: sonographic and computed tomographic appearance. (3969483)
1985
43
Ovarian vein thrombophlebitis: diagnosis by ultrasound and CT. (6429210)
1984
44
Deep venous thrombophlebitis associated with lithium toxicity. (6431115)
1984
45
Thrombophlebitis in BehAset's disease: two causes of diagnostic error. (6732889)
1984
46
Thrombophlebitis migrans. An unusual presentation as a collagen vascular disease--report of a case. (4147715)
1973
47
Fulminating thrombophlebitis migrans. (13118959)
1954
48
Thrombophlebitis migrans; report of a case. (18136551)
1949
49
Antihistamine therapy in thrombophlebitis migrans; a case report. (18117633)
1949
50
The ambulatory treatment of phlebitis, thrombophlebitis, and thrombosis with compression bandages. (20240252)
1947

Variations for Thrombophlebitis

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Expression for genes affiliated with Thrombophlebitis

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Expression patterns in normal tissues for genes affiliated with Thrombophlebitis

Search GEO for disease gene expression data for Thrombophlebitis.

Pathways for genes affiliated with Thrombophlebitis

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Pathways related to Thrombophlebitis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SERPINC1, TGFB1
29.6PLAT, SERPINF2
3
Show member pathways
9.4F2, PROC, PROS1
4
Show member pathways
9.4PROS1, PROC, F2
58.9CRP, F8, PROC, APOH
6
Show member pathways
8.8TGFB1, SERPINF2, PROS1, F8, F5
7
Show member pathways
8.2F2, SERPINC1, PROC, PROS1, F3, F8
8
Show member pathways
thioredoxin pathway37
8.2F2, MTHFR, PLAT, CRP
9
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
7.3F5, PLAT, F8, F3, PROS1, PROC
10
Show member pathways
7.3SERPINC1, SERPINF2, F2, PROC, PROS1, F3
11
Show member pathways
6.8F5, PLAT, F8, F3, PROS1, PROC

Compounds for genes affiliated with Thrombophlebitis

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Compounds related to Thrombophlebitis according to GeneCards/GeneDecks:

(show top 50)    (show all 205)
idCompoundScoreTop Affiliating Genes
1inogatran449.5F3, F2, F5, SERPINC1
2ecarin449.5SERPINC1, F2, F3, F5
3danaparoid449.4F2, SERPINC1, F3, F5
4ximelagatran44 1110.4F2, F3, SERPINC1, F5
5heparinoids449.4F5, F3, SERPINC1, F2
6kaolin449.3F8, F3, F5, F2, APOH
7coumarins449.3APOH, F3, F5, F2
8hydroxyethyl starch449.3F3, SERPINC1, F8, F2
9cardiolipin44 1110.2F2, APOH, F3, F8, F5
10gamma-carboxyglutamic acid449.2F5, F3, PROS1, PROC, F2
11ancrod449.2SERPINC1, F5, PLAT, F2
12fibrinopeptide a449.1F2, PLAT, SERPINC1, SERPINF2
13spectrozyme448.9F2, SERPINC1, F3, PLAT, F5
14fondaparinux448.9PLAT, SERPINC1, F2, F5, F3
15bivalirudin44 119.9F2, F5, PLAT, F3, SERPINC1
16argatroban44 119.9F2, F5, PLAT, F3, SERPINC1
17protamine sulfate448.9PLAT, F2, F5, F3, SERPINC1
18levonorgestrel44 61 28 1111.9F2, SERPINC1, PLAT, F3, F5
19protamine448.7F2, F5, F3, SERPINC1, PLAT
20dermatan sulfate448.7SERPINC1, F2, F5, F3, PLAT
21phospholipid448.5F2, APOH, F5, F3, PROC, F8
22ppack448.4SERPINC1, F3, F2, PLAT
23tranexamic acid44 119.4F2, PLAT, F8, F3, EPO, SERPINC1
24kininogen448.4SERPINC1, F2, APOH, SERPINF2, F3, F5
25hirudin448.4F5, PLAT, F3, SERPINC1, SERPINF2, F2
26gabexate mesilate448.4CRP, PLAT, SERPINC1, F5
27epsilon aminocaproic acid448.4F2, PLAT, SERPINF2, SERPINC1, F3, EPO
28tirofiban44 119.3F2, SERPINC1, PLAT, CRP, F3
29abciximab44 119.3PLAT, F2, CRP, SERPINC1, F3
30polyethylene glycol448.2TGFB1, F8, CRP, SERPINC1, F5, F2
31endotoxin448.2F8, SERPINF2, F3, F5, APOH, CRP
32clopidogrel44 50 24 1111.2F2, F3, SERPINC1, CRP, PLAT
33cyclophosphamide44 50 1110.1F8, F5, F3, MTHFR, APOH, CRP
34aprotinin44 119.1EPO, F3, SERPINC1, F2, F5, PLAT
35citrate447.9SERPINC1, CRP, F5, F8, F2, F3
36folate447.9MTHFR, SERPINC1, EPO, F5, CRP, APOH
37desmopressin44 61 28 1110.8F5, PLAT, F8, F3, EPO, SERPINC1
38ristocetin447.8F2, SERPINF2, F5, PLAT, F8, F3
39warfarin44 50 24 1110.7F5, F8, MTHFR, F3, PROC, SERPINC1
40prostacyclin447.6CRP, PLAT, F5, PROS1, SERPINC1, F3
41cholesterol44 28 24 1110.4MTHFR, APOH, PROS1, PLAT, SERPINF2, F8
42homocysteine44 248.2F5, CRP, PLAT, F8, MTHFR, F3
43alanine447.1F2, CRP, TGFB1, F8, MTHFR, SERPINC1
44aspartate447.1F3, MTHFR, F8, PLAT, EPO, F5
45heparin44 28 24 1110.0PROS1, F2, APOH, SERPINF2, SERPINC1, PROC
46vegf446.9TGFB1, F3, PROS1, F8, CRP, F5
47serine446.7SERPINF2, SERPINC1, PROC, TGFB1, PLAT, F8
48aspirin44 50 28 249.6APOH, F2, TGFB1, SERPINC1, F5, CRP
49fibrinogen446.6F2, F5, CRP, PLAT, F8, F3
50creatinine445.8F5, CRP, PLAT, F8, MTHFR, F3

GO Terms for genes affiliated with Thrombophlebitis

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Cellular components related to Thrombophlebitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310128.9PLAT, F3, APOH
2platelet alpha granule lumenGO:0310938.9TGFB1, SERPINF2, PROS1, F8, F5
3Golgi lumenGO:0057968.8F2, TGFB1, PROC, PROS1
4blood microparticleGO:0725628.6F2, TGFB1, SERPINF2, SERPINC1, PROS1
5plasma membraneGO:0058868.0TGFB1, SERPINC1, PROC, F3, F8, F5
6cell surfaceGO:0099867.9APOH, TGFB1, SERPINF2, EPO, F3, PLAT
7extracellular spaceGO:0056156.0F5, F2, APOH, TGFB1, SERPINF2, SERPINC1
8extracellular regionGO:0055766.0SERPINC1, SERPINF2, TGFB1, F2, EPO, PROC

Biological processes related to Thrombophlebitis according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of blood coagulationGO:03019510.0APOH, PROC
2positive regulation of blood coagulationGO:0301949.9APOH, F2
3blood coagulation, intrinsic pathwayGO:0075979.8F2, APOH, F8
4negative regulation of fibrinolysisGO:0519189.8SERPINF2, APOH, F2
5plasminogen activationGO:0316399.8PLAT, APOH
6peptidyl-glutamic acid carboxylationGO:0171879.7PROS1, PROC, F2
7negative regulation of endopeptidase activityGO:0109519.7SERPINF2, SERPINC1, PROS1
8leukocyte migrationGO:0509009.6F2, PROC, PROS1
9positive regulation of collagen biosynthetic processGO:0329679.5SERPINF2, TGFB1, F2
10response to interleukin-1GO:0705559.5MTHFR, EPO
11blood circulationGO:0080159.5EPO, MTHFR, F5
12negative regulation of proteolysisGO:0458619.3PLAT, F2
13post-translational protein modificationGO:0436879.1PROS1, PROC, F2
14fibrinolysisGO:0427309.1F2, SERPINF2, PROS1, PLAT
15platelet degranulationGO:0025769.1TGFB1, SERPINF2, PROS1, F8, F5
16proteolysisGO:0065089.0PLAT, PROS1, PROC, F2
17acute-phase responseGO:0069539.0F2, SERPINF2, F8, CRP
18agingGO:0075688.8CRP, EPO, TGFB1
19platelet activationGO:0301688.7F2, TGFB1, SERPINF2, PROS1, F8, F5
20response to hypoxiaGO:0016668.3CRP, PLAT, MTHFR, TGFB1
21blood coagulationGO:0075967.1F5, F2, TGFB1, SERPINF2, SERPINC1, PROC

Molecular functions related to Thrombophlebitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.8PROS1, SERPINF2
2protease bindingGO:0020209.2F3, SERPINC1, SERPINF2
3serine-type endopeptidase activityGO:0042528.6F5, PLAT, F8, PROC, F2
4protein bindingGO:0055155.4SERPINC1, SERPINF2, TGFB1, APOH, F2, EPO

Products for genes affiliated with Thrombophlebitis

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Sources for Thrombophlebitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet