MCID: THR016
MIFTS: 65

Thrombophlebitis malady

Cardiovascular diseases, Blood diseases categories

Summaries for Thrombophlebitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Thrombophlebitis is phlebitis (vein inflammation) related to a thrombus (blood clot). When it occurs... more...

MalaCards: Thrombophlebitis, also known as phlebitis and thrombophlebitis of superficial vessels of lower extremities, is related to pulmonary embolism and mondor disease. An important gene associated with Thrombophlebitis is APOH (apolipoprotein H (beta-2-glycoprotein I)), and among its related pathways are Dissolution of Fibrin Clot and PTM: gamma carboxylation, hypusine formation and arylsulfatase activation. The drugs heparin and heparin sodium and the compounds aspartate and warfarin have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and myeloid, and related mouse phenotypes are integument and cardiovascular system.

Aliases & Classifications for Thrombophlebitis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Blood diseases


Aliases & Descriptions:

thrombophlebitis 8 44 60
phlebitis and thrombophlebitis of superficial vessels of lower extremities 8
thrombophlebitis of superficial veins of lower extremity 8
thrombophlebitis of a superficial leg vein nos 8
superficial thrombophlebitis of leg 8
thrombophlebitis nos 8


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Disease Ontology8 DOID:3875
NCIt39 C3410
MeSH34 D013924
ICD1025 I80.0

Related Diseases for Thrombophlebitis

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17GeneCards, 18GeneDecks
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Diseases related to Thrombophlebitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 287)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary embolism30.6F5, MTHFR, PROS1, F3, F2, PLAT
2mondor disease30.3F5, APOH
3hepatitis30.2F8, F2
4pancreatitis30.1CRP, TGFB1
5hepatitis a30.0F2, F8
6ulcerative colitis30.0CRP
7crohn's disease30.0CRP
8acute leukemia30.0MTHFR, EPO
9leukemia30.0F8, MTHFR, EPO, SERPINF2, TGFB1
10protein c deficiency30.0SERPINC1, F2, APOH, F5, MTHFR, PROS1
11multiple sclerosis29.9TGFB1
12myeloma29.9EPO
13postphlebitic syndrome29.9SERPINC1, F5
14meningitis29.9CRP
15behcet's disease29.9APOH, CRP, F5
16antiphospholipid syndrome29.9APOH, F8, F5, MTHFR, PROS1, F3
17myocardial infarction29.9F5, MTHFR, F3, PLAT, SERPINC1, SERPINF2
18cystic fibrosis29.7F8
19purpura29.7SERPINC1
20prostatitis29.7PROS1
21ischemia29.7PLAT
22polycythemia vera29.7EPO
23hereditary hemorrhagic telangiectasia29.7TGFB1
24hepatitis b29.7F2, F8
25pancreatic cancer29.7TGFB1
26factor xii deficiency29.7F5, F3
27obesity29.7CRP
28acute pancreatitis29.7CRP
29arteriosclerosis29.7MTHFR
30mediastinitis29.7CRP
31adenocarcinoma29.7PROS1, TGFB1
32homocystinuria29.7F5, MTHFR, SERPINC1
33blood platelet disease29.7F8, F3, SERPINC1
34pneumonia29.7CRP, TGFB1
35arthritis29.7TGFB1, CRP
36factor v deficiency29.7F8, F5, F3, F2
37uremia29.7CRP, EPO
38breast cancer29.7TGFB1, PLAT, MTHFR
39rheumatoid arthritis29.7MTHFR, CRP, APOH
40antithrombin iii deficiency29.7APOH, F5, MTHFR, PROS1, F2, SERPINC1
41lupus erythematosus29.7APOH, F5, PROS1, F3, F2, SERPINC1
42systemic lupus erythematosus29.6APOH, F8, CRP, F3, F2
43coronary artery disease29.6CRP, MTHFR, F3, PLAT
44protein s deficiency29.6APOH, F8, F5, MTHFR, PROS1, F3
45thrombocytosis29.6SERPINC1, SERPINF2, CRP, EPO, F3, F2
46vascular disease29.6APOH, CRP, F5, MTHFR, F3, PLAT
47hypertension29.6TGFB1, PLAT, F2, PROS1, MTHFR, F5
48thrombophilia29.6APOH, F8, F5, MTHFR, PROS1, PROC
49thrombophlebitis migrans10.6
50appendicitis10.4

Graphical network of the top 20 diseases related to Thrombophlebitis:



Diseases related to thrombophlebitis

Clinical Features for Thrombophlebitis

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Drugs & Therapeutics for Thrombophlebitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Thrombophlebitis

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Anatomical Context for Thrombophlebitis

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32MalaCards
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MalaCards organs/tissues related to Thrombophlebitis:

32
Lung, Breast, Myeloid, Liver, Tongue, Endothelial, Testes, Prostate, Placenta, Skin, Bone, Pancreas, Colon, Heart, Retina, Brain, Pituitary

Animal Models for Thrombophlebitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thrombophlebitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0PROS1, F2, TGFB1
2MP:00053858.7CRP, EPO, F3, F2
3MP:00053707.7F5, PROS1, PROC, EPO, SERPINC1, TGFB1
4MP:00053807.4F5, PROS1, EPO, F3, F2, SERPINC1
5MP:00036317.0F5, MTHFR, PROS1, PROC, F3, F2
6MP:00053877.0CRP, PROC, F3, F2, PLAT, SERPINC1
7MP:00053976.9F8, PROS1, PROC, EPO, F3, F2
8MP:00107686.1APOH, F8, F5, MTHFR, PROS1, PROC
9MP:00053765.2TGFB1, APOH, F8, CRP, F5, MTHFR

Publications for Thrombophlebitis

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Sources:
50PubMed
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Articles related to Thrombophlebitis:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
Jugular thrombophlebitis in horses: a review of fibrinolysis, thrombus formation, and clinical management. (23814304)
2013
2
Atypical Lemierre syndrome, thrombophlebitis of the facial vein. (23041486)
2013
3
Re-examination of features to distinguish polyarteritis nodosa from superficial thrombophlebitis. (23392132)
2013
4
Thrombophlebitis of the head and neck caused by eosinophilic otitis media. (23598703)
2013
5
Thrombophlebitis of the internal jugular vein (Lemierre syndrome): clinical and CT findings. (23528567)
2013
6
Candidal thrombophlebitis of central veins: case report and review. (21905947)
2012
7
Challenging presentations of cavernous sinus thrombophlebitis. (22139823)
2012
8
Thrombophlebitis of the head and neck: report of two cases. (20189329)
2010
9
Idiopathic superficial thrombophlebitis and the incidence of cancer in primary care patients. (20065278)
2010
10
Extended septic thrombophlebitis in a patient with duplicated inferior vena cava: case report and review of literature. (19174747)
2009
11
Superficial vein thrombophlebitis--serious concern or much ado about little? (18512540)
2008
12
Intravenous heparin in combination with antibiotics for the treatment of deep vein septic thrombophlebitis: a systematic review. (17222406)
2007
13
Superficial thrombophlebitis. (17544957)
2007
14
Excision of internal jugular vein for catheter-related thrombophlebitis. (16362464)
2006
15
Restricted diffusion in bilateral optic nerves and retinas as an indicator of venous ischemia caused by cavernous sinus thrombophlebitis. (17032847)
2006
16
Unilateral erythema nodosum-like lesions and superficial thrombophlebitis together with ipsilateral thrombosis of the vena femoralis in BehAset's disease. (17229626)
2006
17
Lemierre syndrome with jugular thrombophlebitis and cavitary pneumonia. (16038226)
2005
18
Evaluation of risk factors for development of catheter-associated jugular thrombophlebitis in horses: 50 cases (1993-1998). (16220676)
2005
19
Superficial thrombophlebitis of the legs: still a lot to learn. (15946201)
2005
20
Deep septic thrombophlebitis: an unrecognized cause of relapsing bacteremia in patients with cancer. (15084634)
2004
21
F-18-fluorodeoxyglucose positron emission tomography leading to a diagnosis of septic thrombophlebitis of the portal vein: description of a case history and review of the literature. (14871467)
2004
22
Septic thrombophlebitis of the portal and superior mesenteric veins as a complication of appendicitis: report of a case. (14745623)
2004
23
Septic thrombophlebitis of the hepatic veins after colonoscopy: a case report. (12838249)
2003
24
Morbidity in superficial thrombophlebitis and its potential surgical prevention. (12661427)
2003
25
Angiopericytomatosis and subcutaneus thrombophlebitis in multiple myeloma. (12410733)
2002
26
Ligation versus anticoagulation: treatment of above-knee superficial thrombophlebitis not involving the deep venous system. (11708514)
2001
27
The world's first case of Serratia liquefaciens intravascular catheter-related suppurative thrombophlebitis and native valve endocarditis. (11168051)
2000
28
Surgical management of ascending saphenous thrombophlebitis. (10811526)
1999
29
Imaging of puerperal septic thrombophlebitis: primary role for sonography. (9574625)
1998
30
Saphenous vein thrombophlebitis (SVT): a deceptively benign disease. (9576081)
1998
31
Peripheral parenteral nutrition and venous thrombophlebitis. (9263244)
1997
32
Imaging of puerperal septic thrombophlebitis: prospective comparison of MR imaging, CT, and sonography. (9308461)
1997
33
Septic pelvic thrombophlebitis or refractory postpartum fever of undetermined etiology. (8972414)
1996
34
Jugular thrombophlebitis complicating bacterial pharyngitis (Lemierre's syndrome). (8587815)
1996
35
The incidence of deep venous thrombosis in patients with superficial thrombophlebitis of the lower limbs. (8326661)
1993
36
Laparoscopic diagnosis of puerperal ovarian vein thrombophlebitis. A case report. (8501741)
1993
37
Cavernous sinus thrombophlebitis in Zimbabwe. (1806252)
1991
38
Candidal suppurative thrombophlebitis in a premature infant. (3344709)
1988
39
Iliofemoral thrombophlebitis presenting as an acute abdomen: report and literature review. (3291613)
1988
40
Thrombophlebitis with diazepam and ampicillin. (3215685)
1988
41
Are patients with multiple sclerosis protected from thrombophlebitis and pulmonary embolism? (3263261)
1988
42
Thrombophlebitis and disturbed hemostasis following administration of intravenous hematin in normal volunteers. (3177402)
1988
43
Role of intravenous heparin and hydrocortisone in prevention of infusion thrombophlebitis. (3169957)
1988
44
Postabortal septic pelvic thrombophlebitis diagnosed with computed tomography. A case report. (3430495)
1987
45
Idiopathic spontaneous deep venous thrombophlebitis in an adolescent: a case report. (3840661)
1985
46
Thrombophlebitis in BehAset's disease. (4072376)
1985
47
Thrombophlebitis: an unusual cause of chest pain. (3866169)
1985
48
Ovarian vein thrombophlebitis: diagnosis by ultrasound and CT. (6429210)
1984
49
Cavernous sinus thrombophlebitis secondary to sphenoid sinusitis. (6855403)
1983
50
Deep thrombophlebitis and pulmonary embolism in thromboangiitis obliterans. (13016604)
1953

Genetic Variations for Thrombophlebitis

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Expression for genes affiliated with Thrombophlebitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thrombophlebitis

Search GEO for disease gene expression data for Thrombophlebitis.

Pathways for genes affiliated with Thrombophlebitis

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 51QIAGEN, 52R&D Systems, 29KEGG
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Pathways related to Thrombophlebitis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8SERPINF2, PLAT
29.5F2, PROC, PROS1
39.5PROS1, PROC, F2
4
Hide members
9.4F3, F2, SERPINF2
5
Hide members
9.4PROC, PROS1, F5, F8
69.1CRP, F2, PLAT
79.1PROC, CRP, F8, APOH
8
Hide members
9.1F2, F3, PROC, PROS1
9
Hide members
8.6F8, F5, PROS1, SERPINF2, TGFB1
10
Hide members
8.5F5, PROS1, PROC, F3, F2, SERPINC1
11
Hide members
8.3F8, F5, PROS1, PROC, F3, F2
12
Hide members
7.6F8, F5, PROS1, PROC, F3, F2
13
Hide members
7.6SERPINF2, F8, SERPINC1, PLAT, F2, F3

Compounds for genes affiliated with Thrombophlebitis

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Thrombophlebitis according to GeneCards/GeneDecks:

(show top 50)    (show all 170)
idCompoundScoreTop Affiliating Genes
1aspartate4410.2F2, F8
2warfarin44 49 11 2413.1SERPINC1, PROC, APOH
3coumarins4410.0F3, APOH
4heparin44 28 11 2412.7MTHFR, PROS1, F8, APOH
5Drotrecogin alfa119.6PROS1, F8, F2, F5
6inogatran449.5F3, F2, F5, SERPINC1
7ecarin449.5SERPINC1, F5, F2, F3
8ancrod449.5PLAT, SERPINC1, F2, F5
9fibrinopeptide a449.5PLAT, SERPINC1, SERPINF2, F2
10danaparoid449.5F3, SERPINC1, F2, F5
11ximelagatran44 1110.5SERPINC1, F3, F5, F2
12heparinoids449.4SERPINC1, F2, F3, F5
13serine449.4TGFB1, F8, PROS1
14kaolin449.4F8, F3, F5, F2, APOH
15hydroxyethyl starch449.3F8, F3, F2, SERPINC1
16gamma-carboxyglutamic acid449.2PROC, F5, F2, F3, PROS1
17endotoxin449.2F5, APOH, F8, F3
18spectrozyme449.1PLAT, F2, F3, F5, SERPINC1
19ppack449.1F3, SERPINC1, PLAT, F2
20fondaparinux449.1SERPINC1, F5, F2, PLAT, F3
21bivalirudin44 1110.1SERPINC1, PLAT, F2, F3, F5
22argatroban44 1110.1PLAT, F2, F3, SERPINC1, F5
23protamine sulfate449.1SERPINC1, F3, F2, PLAT, F5
24levonorgestrel44 59 28 1112.1SERPINC1, F2, F3, F5, PLAT
25gabexate mesilate449.1CRP, SERPINC1, PLAT, F5
26protamine449.0F3, F2, PLAT, SERPINC1, F5
27dermatan sulfate448.8SERPINC1, PLAT, F2, F3, F5
28tirofiban44 119.7F3, CRP, SERPINC1, F2, PLAT
29abciximab44 119.7PLAT, F2, CRP, SERPINC1, F3
30aprotinin44 119.7SERPINC1, F3, EPO, F5, SERPINF2, PLAT
31clopidogrel49 44 11 2411.7SERPINC1, PLAT, F2, F3, CRP
32kininogen448.6PLAT, F3, SERPINC1, F5, APOH, F2
33hirudin448.6SERPINC1, F3, F5, F8, F2, SERPINF2
34tranexamic acid44 119.6SERPINC1, F2, PLAT, F8, EPO, F3
35epsilon aminocaproic acid448.6SERPINF2, SERPINC1, EPO, PLAT, F3, F2
36vitamin b12448.5CRP, APOH, EPO, F5, MTHFR
37phospholipid448.4F5, PROC, F3, APOH, F2, PROS1
38cyclophosphamide44 49 1110.3CRP, F8, APOH, MTHFR, F3, F5
39polyethylene glycol448.2SERPINC1, F2, F5, TGFB1, CRP, F8
40ristocetin448.1SERPINF2, SERPINC1, PLAT, F2, F3, EPO
41desmopressin44 59 28 1111.1F3, EPO, F5, F8, F2, PLAT
42prostacyclin448.1APOH, CRP, PLAT, F5, F3, SERPINC1
43folate447.9CRP, MTHFR, APOH, SERPINC1, EPO, F5
44citrate447.8F2, F8, CRP, SERPINC1, F3, F5
45homocysteine44 248.7SERPINC1, PLAT, F2, F3, MTHFR, F5
46fibrinogen447.1F2, F3, PROC, MTHFR, CRP, F8
47alanine447.1F3, CRP, F5, MTHFR, TGFB1, SERPINC1
48aspirin44 49 28 249.9TGFB1, SERPINC1, PLAT, F2, F3, MTHFR
49vegf446.8F5, CRP, PROS1, EPO, F3, SERPINF2
50creatinine446.0APOH, PLAT, F2, F3, EPO, CRP

GO Terms for genes affiliated with Thrombophlebitis

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16Gene Ontology
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Cellular components related to Thrombophlebitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057968.7TGFB1, F2, PROC, PROS1
2platelet alpha granule lumenGO:0310938.5F8, F5, PROS1, SERPINF2, TGFB1
3cell surfaceGO:0099867.5APOH, EPO, F3, PLAT, SERPINF2, TGFB1
4extracellular regionGO:0055766.1PROS1, F5, CRP, F8, PROC, EPO
5extracellular spaceGO:0056156.1TGFB1, APOH, F8, CRP, F5, EPO

Biological processes related to Thrombophlebitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:0316399.9PLAT, APOH
2positive regulation of blood coagulationGO:0301949.9APOH, F2
3negative regulation of fibrinolysisGO:0519189.9APOH, F2, SERPINF2
4blood coagulation, intrinsic pathwayGO:0075979.9F2, F8, APOH
5negative regulation of blood coagulationGO:0301959.9PROC, APOH
6peptidyl-glutamic acid carboxylationGO:0171879.8F2, PROC, PROS1
7negative regulation of endopeptidase activityGO:0109519.7PROS1, SERPINC1, SERPINF2
8negative regulation of proteolysisGO:0458619.7PLAT, F2
9blood circulationGO:0080159.5EPO, MTHFR, F5
10fibrinolysisGO:0427309.4PROS1, F2, PLAT, SERPINF2
11acute-phase responseGO:0069539.3SERPINF2, F2, CRP, F8
12positive regulation of collagen biosynthetic processGO:0329679.2F2, SERPINF2, TGFB1
13leukocyte migrationGO:0509009.2F2, PROC, PROS1
14platelet degranulationGO:0025768.9F8, F5, PROS1, SERPINF2, TGFB1
15agingGO:0075688.6TGFB1, EPO, CRP
16platelet activationGO:0301688.5F8, F5, PROS1, F2, SERPINF2, TGFB1
17blood coagulationGO:0075967.1TGFB1, F8, F5, PROS1, PROC, F3

Molecular functions related to Thrombophlebitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.5SERPINF2, SERPINC1, F3
2protein bindingGO:0055155.4TGFB1, APOH, F8, CRP, F5, PROC

Products for genes affiliated with Thrombophlebitis

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  • Antibodies
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Sources for Thrombophlebitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet