MCID: THR016
MIFTS: 53

Thrombophlebitis malady

Categories: Cardiovascular diseases, Blood diseases

Aliases & Classifications for Thrombophlebitis

Aliases & Descriptions for Thrombophlebitis:

Name: Thrombophlebitis 12 29 52 42 14 69
Phlebitis and Thrombophlebitis of Superficial Vessels of Lower Extremities 12
Thrombophlebitis of Superficial Veins of Lower Extremity 12
Thrombophlebitis of a Superficial Leg Vein Nos 12
Superficial Thrombophlebitis of Leg 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3875
ICD10 33 I80.0
ICD9CM 35 451.0
MeSH 42 D013924
NCIt 47 C3410

Summaries for Thrombophlebitis

Disease Ontology : 12 A phlebitis that results from a blood clot in the vessel.

MalaCards based summary : Thrombophlebitis, also known as phlebitis and thrombophlebitis of superficial vessels of lower extremities, is related to influenza and lupus erythematosus. An important gene associated with Thrombophlebitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Dalteparin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and myeloid, and related phenotypes are homeostasis/metabolism and mortality/aging

Wikipedia : 71 Thrombophlebitis is phlebitis or vein inflammation related to a thrombus, which is a blood clot. When it... more...

Related Diseases for Thrombophlebitis

Diseases related to Thrombophlebitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 272)
id Related Disease Score Top Affiliating Genes
1 influenza 29.3 F2 SERPINC1 SERPINF2
2 lupus erythematosus 29.3 PLAT SERPINC1
3 prostatitis 29.2 APOH F2
4 myocardial infarction 28.2 F2 F5 F8 MTHFR PLAT SERPINC1
5 budd-chiari syndrome 28.1 APOH F2 F5 MTHFR PLAT SERPINC1
6 thrombophlebitis migrans 12.3
7 femoral vein thrombophlebitis 12.1
8 iliac vein thrombophlebitis 11.9
9 lemierre's syndrome 11.3
10 mondor disease 10.8
11 chorioretinal scar 10.3 F2 SERPINC1
12 congenital insensitivity to pain with severe intellectual disability 10.3 F2 F5
13 oxyphilic adenoma 10.2 F2 F5
14 scn8a-related epilepsy with encephalopathy 10.2 F2 MTHFR
15 schwannoma of jugular foramen 10.2 F2 SERPINC1
16 multiple familial trichoepithelioma 10.2 F5 MTHFR
17 porphyria 10.2 F2 MTHFR
18 cerebellar astrocytoma 10.2 F2 SERPINC1
19 angelucci's syndrome 10.2 F2 SERPINC1
20 melorheostosis 10.2 PLAT SERPINC1
21 ovarian papillary cystadenoma 10.2 F2 SERPINC1
22 fanconi-bickel syndrome 10.2 PLAT SERPINC1
23 silent myocardial infarction 10.2 PLAT SERPINC1
24 thrombosis 10.2
25 alpha-2-macroglobulin deficiency 10.2 F2 F8
26 coloboma of optic papilla 10.2 SERPINC1 SERPINF2
27 acrodysplasia with ossification abnormalities, short stature and fibular hypoplasia 10.2 F5 F8
28 erythrocytosis, familial, 4 10.2 F5 F8
29 dyskinetic cerebral palsy 10.2 F2 F8
30 acrodysplasia scoliosis 10.2 F5 F8
31 kondoh syndrome 10.2 F2 PLAT
32 social phobia 10.2 F2 F8
33 pancreatic ductal carcinoma 10.2 F2 F5 SERPINC1
34 coccidioidomycosis 10.2 F2 PLAT
35 autonomic neuropathy 10.2 F2 F8
36 mixed epithelial tumor of ovary 10.1 F2 MTHFR SERPINC1
37 oguchi disease-2 10.1 F2 F5 SERPINC1
38 alpha-2-plasmin inhibitor deficiency 10.1 F2 MTHFR SERPINC1
39 myosclerosis, congenital 10.1 F5 MTHFR SERPINC1
40 neutropenia 10.1 MTHFR SERPINE1
41 capillary hemangioma 10.1 F2 MTHFR SERPINC1
42 photosensitive epilepsy 10.1 F2 F5 MTHFR
43 gastrointestinal defects and immunodeficiency syndrome 10.1 F5 MTHFR
44 houlston ironton temple syndrome 10.1 F2 F5 MTHFR
45 infiltrating ureter transitional cell carcinoma 10.1 F2 F8
46 villous adenoma 10.1 F2 F5 MTHFR
47 cleft lip 10.1 F5 MTHFR SERPINC1
48 spinocerebellar ataxia 27 10.1 F2 F8
49 cerebral calcifications opalescent teeth phosphaturia 10.1 PLAT SERPINE1
50 miller-dieker lissencephaly syndrome 10.1 F2 SERPINC1 SERPINF2

Graphical network of the top 20 diseases related to Thrombophlebitis:



Diseases related to Thrombophlebitis

Symptoms & Phenotypes for Thrombophlebitis

MGI Mouse Phenotypes related to Thrombophlebitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 SERPINF2 APOH F2 F5 F8 MTHFR
2 mortality/aging MP:0010768 9.23 APOH F2 F5 F8 MTHFR PLAT

Drugs & Therapeutics for Thrombophlebitis

Drugs for Thrombophlebitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dalteparin Approved Phase 4,Phase 3,Phase 1 9041-08-1
2
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1 9005-49-6 772 46507594
3
Ibuprofen Approved Phase 4 15687-27-1 3672
4
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
5
Etomidate Approved Phase 4 33125-97-2 36339 667484
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
7
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
8
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
9 Anticoagulants Phase 4,Phase 3,Phase 1
10 calcium heparin Phase 4,Phase 3,Phase 1
11 Calcium, Dietary Phase 4,Phase 3,Phase 1
12 Fibrinolytic Agents Phase 4,Phase 3,Phase 1
13 Heparin, Low-Molecular-Weight Phase 4,Phase 3,Phase 1
14 Analgesics Phase 4
15 Analgesics, Non-Narcotic Phase 4
16 Anti-Inflammatory Agents Phase 4,Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4
18 Antirheumatic Agents Phase 4
19 Cyclooxygenase Inhibitors Phase 4
20 Peripheral Nervous System Agents Phase 4,Phase 3
21 Heparinoids Phase 4,Phase 3
22 Salicylates Phase 4
23 Adjuvants, Anesthesia Phase 4
24 Analgesics, Opioid Phase 4
25 Anesthetics Phase 4
26 Anesthetics, General Phase 4
27 Anesthetics, Intravenous Phase 4
28 Anti-Anxiety Agents Phase 4,Phase 3
29 Central Nervous System Depressants Phase 4,Phase 3
30 GABA Agents Phase 4
31 GABA Modulators Phase 4
32 Hypnotics and Sedatives Phase 4
33 Narcotics Phase 4
34 Neurotransmitter Agents Phase 4,Phase 3
35 Psychotropic Drugs Phase 4,Phase 3
36 Tranquilizing Agents Phase 4,Phase 3
37
Amiodarone Approved, Investigational Phase 3 1951-25-3 2157
38
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
39
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
40
Alizapride Approved Phase 3 59338-93-1 43008
41
Aprepitant Approved, Investigational Phase 3 170729-80-3 151165 6918365
42
Chlorpromazine Approved, Vet_approved Phase 3 50-53-3 2726
43
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
44
Dolasetron Approved Phase 3 115956-12-2 60654
45
Domperidone Approved, Investigational, Vet_approved Phase 3 57808-66-9 3151
46
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
47
Droperidol Approved, Vet_approved Phase 3 548-73-2 3168
48
Fluphenazine Approved Phase 3 69-23-8 3372
49
Fosaprepitant Approved Phase 3 172673-20-0 219090
50
Granisetron Approved, Investigational Phase 3 109889-09-0 3510

Interventional clinical trials:

(show all 30)
id Name Status NCT ID Phase
1 Efficacy of Low Molecular Weight Heparin in Superficial Vein Thrombosis Unknown status NCT01245998 Phase 4
2 Preventing the Development of Venous Insufficiency in Pregnant Women Through Use of Compression Stockings Unknown status NCT01793194 Phase 4
3 Management of Superficial Thrombophlebitis Completed NCT00264381 Phase 4
4 Topical Diclofenac Gel in Patients With Superficial Inflammation of the Veins Completed NCT00377806 Phase 4
5 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4
6 Etomidate vs Propofol-Induction Characteristics Completed NCT02807610 Phase 4
7 Safety and Efficacy of Oral Versus Intravenous Amiodarone in the Treatment of AF Unknown status NCT01817439 Phase 3
8 Evaluation Of Fondaparinux (Also Called ARIXTRA) 2.5 mg Subcutaneously Once Daily For The Treatment Of Superficial Thrombophlebitis (Also Known As Superficial Vein Thrombosis) Completed NCT00443053 Phase 3
9 Different Doses and Duration of Low Molecular Weight Heparin (Parnaparin)in Superficial Vein Thrombosis Completed NCT00362947 Phase 3
10 Evaluation of Long-Term Sequelae After Thrombophlebitis, i.e. Deep Venous Thrombosis of the Lower Extremities Completed NCT00628576 Phase 3
11 Efficacy and Safety of Fosaprepitant Dimeglumine in Preventing Chemotherapy-Induced Nausea and Vomiting (MK-0517-031) Completed NCT01594749 Phase 3
12 Boston Area Anticoagulation Trial for Atrial Fibrillation (BAATAF) Completed NCT00000517 Phase 3
13 Prevention of Venous and Arterial Thromboembolism, in Cancer Patients Undergoing Chemotherapy, With a Low Molecular Weight Heparin (Nadroparin Calcium) Completed NCT00951574 Phase 3
14 Efficacy Comparison of Topical and Intravenous Tranexamic Acid to Reduce the Number of Blood Transfusions in TKA Completed NCT01881568 Phase 3
15 Homeopathy for Post-operative (C. Section) Recovery Completed NCT00725569 Phase 2, Phase 3
16 Efficacy and Tolerability of Hirudoid Cream in Prophylaxis and Treatment Infusion Phlebitis Recruiting NCT01943006 Phase 3
17 Progesterone for the Treatment of Traumatic Brain Injury III Terminated NCT00822900 Phase 3
18 Treatment for Blood Clots in the Veins of the Legs Completed NCT00001713 Phase 1
19 Comparing Anti-XA Levels in Post-Cesarean Patients Undergoing Enoxaparin Thromboprophylaxis Completed NCT02070237 Phase 1
20 Phase I Trial of IV Fenretinide (4-HPR) Plus IV Safingol for Patients With Relapsed Malignancies Recruiting NCT01553071 Phase 1
21 Aromatase Inhibitors for Treatment of Uterine Leiomyomas Withdrawn NCT00945360 Phase 1
22 A Monocenter Prospective Study to Evaluate the Efficacy of Peripherally Inserted Central Catheter to Tunnelled Central Catheter With Cuff in Home Parenteral Nutrition for Long-term Used. Unknown status NCT01840033
23 A Complex Contraception Registry Unknown status NCT02219269
24 POST (Prospective Observational Superfial Thrombophlebitis) Completed NCT00818688
25 Trans Radial Versus Transfemoral Route for Coronary Angiography Completed NCT02983721
26 Evaluation of Endovenous Sclerotherapy for Treatment of Varicose Veins Completed NCT00954980
27 Radiofrequency Ablation vs Conventional Surgery for Superficial Venous Insufficiency Completed NCT02588911
28 Ultrasound to Prevent Leg Wound Complications in Heart Bypass. Recruiting NCT02307084
29 Compression Therapy Following Truncal Vein Endothermal Ablation And Distal Sclerotherapy Recruiting NCT02890563
30 Venous Vascularization and Inflammation on Contrast-enhanced Ultrasound (CEUS) in Patients With Thrombosis Terminated NCT01367769

Search NIH Clinical Center for Thrombophlebitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: thrombophlebitis

Genetic Tests for Thrombophlebitis

Genetic tests related to Thrombophlebitis:

id Genetic test Affiliating Genes
1 Thrombophlebitis 29

Anatomical Context for Thrombophlebitis

MalaCards organs/tissues related to Thrombophlebitis:

39
Lung, Breast, Myeloid, Liver, Bone, Testes, Pituitary

Publications for Thrombophlebitis

Articles related to Thrombophlebitis:

(show top 50) (show all 599)
id Title Authors Year
1
Quantitative T2 mapping for detection and quantification of thrombophlebitis in a rabbit model. ( 27866674 )
2017
2
Prevalence of Isolated Asymptomatic Deep Vein Thrombosis in Varicose Vein Patients with Superficial Thrombophlebitis: A Single Center Experience in Japan. ( 27087866 )
2016
3
Necrotizing Thrombophlebitis Secondary to Mycobacterium Chelonae in a Hemodialyzed Patient. ( 27415637 )
2016
4
Thrombophlebitis of cephalic vein in the left forearm related to infliximab infusion. ( 27598885 )
2016
5
Thrombophlebitis of pinna a rare condition: Role of heparin spray. ( 27746576 )
2016
6
Hepatic Infarction Caused by Portal Vein Thrombophlebitis Misdiagnosed as Infiltrative Hepatic Malignancy with Neoplastic Thrombus. ( 27646586 )
2016
7
Initial management and outcomes after superficial thrombophlebitis: The Cardiovascular Research Network Venous Thromboembolism study. ( 27253585 )
2016
8
Incomplete BehAset's disease with calf muscle pain and MRI hyperintensity due to possible thrombophlebitis. ( 27748264 )
2016
9
Clinical Features and Developing Risks of Saphenous Vein Thrombophlebitis. ( 27375800 )
2016
10
Superficial Thrombophlebitis of the Breast in a Patient with an Arteriovenous Fistula for Hemodialysis. ( 26991444 )
2016
11
What Is the Most Effective Treatment of Superficial Thrombophlebitis? ( 26707361 )
2016
12
The role of anticoagulation in the management of pediatric temporal bone septic thrombophlebitis. ( 26666669 )
2016
13
Intestinal Infarction Caused by Thrombophlebitis of the Portomesenteric Veins as a Complication of Acute Gangrenous Appendicitis After Appendectomy: A Case Report. ( 26091450 )
2015
14
Treatment for superficial infusion thrombophlebitis of the upper extremity. ( 26588711 )
2015
15
Internal jugular vein septic thrombophlebitis (lemierre syndrome) as a complication of pharyngitis. ( 25957375 )
2015
16
Superficial thrombophlebitis (superficial venous thrombosis). ( 26099257 )
2015
17
Achromobacter causing a thrombophlebitis and osteomyelitis combination: a rare cause. ( 26347234 )
2015
18
Cavernous sinus thrombophlebitis (sans thrombosis) secondary to odontogenic fascial space infection: an uncommon complication with unusual presentation. ( 25838693 )
2015
19
Diagnosis of Brachiocephalic Thrombophlebitis as the Cause of Fever of Unknown Origin by 18F-FDG-PET/CT. ( 25800595 )
2015
20
Septic thrombophlebitis caused by viridans group Streptococci. ( 25882902 )
2015
21
Cerebral venous sinus thrombophlebitis as a complication of acute otitis media. ( 25440866 )
2015
22
Low-level laser therapy for the treatment of superficial thrombophlebitis after chemotherapy in breast cancer patients: a case study. ( 26834384 )
2015
23
Successful Treatment of Dental Infection-Induced Chronic Cavernous Sinus Thrombophlebitis With Antibiotics and Low-Molecular-Weight Heparin: Two Case Reports. ( 26173405 )
2015
24
Does cryostripping add anything to the treatment of the ascending thrombophlebitis of the great saphenous vein? ( 26546597 )
2015
25
Evaluation and Treatment of Penile Thrombophlebitis (Mondor's Disease). ( 25962547 )
2015
26
Postpartum Ovarian Vein Thrombophlebitis with Staphylococcal Bacteremia. ( 26221549 )
2015
27
Epidemiology and treatment strategies of iliac vein thrombophlebitis. ( 25575974 )
2015
28
Thrombophlebitis of the temporal vein as an extracranial complication of acute bacterial rhinosinusitis. ( 26322458 )
2015
29
Facial vein thrombophlebitis: an uncommon complication of sinusitis. ( 25636529 )
2015
30
Streptococcus constellatus Causing Septic Thrombophlebitis of the Right Ovarian Vein with Extension into the Inferior Vena Cava. ( 26171262 )
2015
31
Superficial Vein Thrombophlebitis in a Football Athlete. ( 25961158 )
2015
32
Rivaroxaban as an effective treatment for recurrent superficial thrombophlebitis related to primary antiphospholipid syndrome. ( 25186062 )
2014
33
Treatment of lower extremity superficial thrombophlebitis. ( 24549553 )
2014
34
Thrombophlebitis of the lateral chest wall (Mondor's disease). ( 24448146 )
2014
35
Cerebral tubercular thrombophlebitis presenting as venous infarct: Magnetic resonance imaging and pathologic correlation. ( 24753682 )
2014
36
Isolated facial vein thrombophlebitis: a variant of lemierre syndrome. ( 25734123 )
2014
37
Ovarian Vein Thrombophlebitis Related to Large Uterine Myoma. ( 24413242 )
2014
38
Sporotrichoid eruption in a patient after lung transplantation. Scedosporium apiospermum fungal thrombophlebitis and sporotrichoid nodules. ( 24258488 )
2014
39
Superficial abdominal thrombophlebitis (Mondor's disease) presenting as loss of response to adalimumab in a Crohn's disease patient. ( 24835166 )
2014
40
A Case of IgG4-Related Disease Presenting as Massive Pleural Effusion and Thrombophlebitis. ( 24851132 )
2014
41
Variability in the Management of Superficial Venous Thrombophlebitis across Practitioners Based in North America and the Global Community. ( 25371819 )
2014
42
Migratory superficial thrombophlebitis in a cannabis smoker. ( 25001627 )
2014
43
A case of cavernous sinus thrombophlebitis and meningitis as a complication in osteopetrosis. ( 25247162 )
2014
44
Deep thrombophlebitis masked by peripheral arthritis in Henoch-SchAPnlein purpura. ( 25496261 )
2014
45
Spontaneous bacterial coronary sinus septic thrombophlebitis treated successfully medically. ( 24749166 )
2014
46
Successful treatment of recurrent candidemia due to candidal thrombophlebitis associated with a central venous catheter using a combination of fosfluconazole and micafungin. ( 24042529 )
2013
47
Point-of-care ultrasound diagnosis of peripheral vein septic thrombophlebitis in the emergency department. ( 22284977 )
2013
48
Variability in the management of superficial venous thrombophlebitis among phlebologists and vascular surgeons. ( 24225503 )
2013
49
Carotid artery free-floating thrombus caused by paradoxical embolization from greater saphenous vein ascending thrombophlebitis. ( 23618593 )
2013
50
Atypical Lemierre syndrome, thrombophlebitis of the facial vein. ( 23041486 )
2013

Variations for Thrombophlebitis

Expression for Thrombophlebitis

Search GEO for disease gene expression data for Thrombophlebitis.

Pathways for Thrombophlebitis

GO Terms for Thrombophlebitis

Cellular components related to Thrombophlebitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 APOH F2 F5 F8 PLAT SERPINC1
2 endoplasmic reticulum lumen GO:0005788 9.56 F2 F5 F8 SERPINC1
3 blood microparticle GO:0072562 9.5 F2 SERPINC1 SERPINF2
4 ER to Golgi transport vesicle GO:0030134 9.37 F5 F8
5 platelet alpha granule lumen GO:0031093 9.26 F5 F8 SERPINE1 SERPINF2
6 extracellular space GO:0005615 9.23 APOH F2 F5 F8 PLAT SERPINC1

Biological processes related to Thrombophlebitis according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.89 F2 F5 F8 PLAT
2 cellular protein metabolic process GO:0044267 9.76 F2 F5 SERPINC1
3 ER to Golgi vesicle-mediated transport GO:0006888 9.73 F2 F5 F8
4 negative regulation of endopeptidase activity GO:0010951 9.72 SERPINC1 SERPINE1 SERPINF2
5 blood coagulation GO:0007596 9.72 F2 F5 F8 PLAT SERPINC1
6 negative regulation of peptidase activity GO:0010466 9.71 SERPINC1 SERPINE1 SERPINF2
7 platelet activation GO:0030168 9.69 F2 F5 F8
8 acute-phase response GO:0006953 9.63 F2 F8 SERPINF2
9 regulation of blood coagulation GO:0030193 9.61 APOH F2 SERPINC1
10 blood circulation GO:0008015 9.6 F5 MTHFR
11 positive regulation of collagen biosynthetic process GO:0032967 9.58 F2 SERPINF2
12 blood coagulation, intrinsic pathway GO:0007597 9.58 APOH F2 F8
13 negative regulation of proteolysis GO:0045861 9.57 F2 PLAT
14 hemostasis GO:0007599 9.56 F2 F5 F8 SERPINC1
15 platelet degranulation GO:0002576 9.55 APOH F5 F8 SERPINE1 SERPINF2
16 positive regulation of blood coagulation GO:0030194 9.54 APOH F2 SERPINE1
17 negative regulation of blood coagulation GO:0030195 9.52 APOH SERPINE1
18 plasminogen activation GO:0031639 9.49 APOH PLAT
19 negative regulation of plasminogen activation GO:0010757 9.48 SERPINE1 SERPINF2
20 fibrinolysis GO:0042730 9.26 F2 PLAT SERPINE1 SERPINF2
21 negative regulation of fibrinolysis GO:0051918 8.92 APOH F2 SERPINE1 SERPINF2

Molecular functions related to Thrombophlebitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.5 APOH F2 SERPINC1
2 peptidase inhibitor activity GO:0030414 9.43 SERPINC1 SERPINE1 SERPINF2
3 serine-type endopeptidase inhibitor activity GO:0004867 9.33 SERPINC1 SERPINE1 SERPINF2
4 protease binding GO:0002020 9.13 SERPINC1 SERPINE1 SERPINF2
5 serine-type endopeptidase activity GO:0004252 8.92 F2 F5 F8 PLAT

Sources for Thrombophlebitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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