MCID: THR016
MIFTS: 68

Thrombophlebitis malady

Cardiovascular diseases, Blood diseases categories

Summaries for Thrombophlebitis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Thrombophlebitis is phlebitis (vein inflammation) related to a thrombus (blood clot). When it occurs... more...

MalaCards: Thrombophlebitis, also known as phlebitis and thrombophlebitis of superficial vessels of lower extremities, is related to mondor disease and pulmonary embolism. An important gene associated with Thrombophlebitis is APOH (apolipoprotein H (beta-2-glycoprotein I)), and among its related pathways are Glypican 1 network and Dissolution of Fibrin Clot. The drugs heparin and heparin sodium and the compounds inogatran and ecarin have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and myeloid, and related mouse phenotypes are liver/biliary system and muscle.

Disease Ontology:9 A phlebitis that results from a blood clot in the vessel.

Aliases & Classifications for Thrombophlebitis

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9Disease Ontology, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Blood diseases


Aliases & Descriptions:

thrombophlebitis 9 46 63
phlebitis and thrombophlebitis of superficial vessels of lower extremities 9
thrombophlebitis of superficial veins of lower extremity 9
thrombophlebitis of a superficial leg vein nos 9
superficial thrombophlebitis of leg 9
thrombophlebitis nos 9


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Disease Ontology9 DOID:3875
NCIt41 C3410
MeSH36 D013924
ICD1026 I80.0

Related Diseases for Thrombophlebitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Thrombophlebitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1mondor disease30.5APOH, F5
2pulmonary embolism30.5APOH, SERPINF2, SERPINC1, PROS1, F3, MTHFR
3arteriovenous fistula30.3EPO
4venous thrombosis30.2F2, APOH, SERPINF2, SERPINC1, PROC, PROS1
5sepsis30.2SERPINC1, PROC, F5, CRP, F3, F2
6behcet's disease30.0F5, APOH, CRP
7protein c deficiency30.0F2, APOH, SERPINC1, PROC, PROS1, MTHFR
8leukemia30.0SERPINF2, EPO, TGFB1, MTHFR, F8
9purpura30.0SERPINC1
10thromboembolism29.9PROC, F3, MTHFR, F8, PLAT, F5
11factor xii deficiency29.9F5, F3
12mediastinitis29.9CRP
13homocystinuria29.8SERPINC1, MTHFR, F5
14protein s deficiency29.8SERPINC1, F5
15factor v deficiency29.8F5, F8, F3, F2
16antiphospholipid syndrome29.7F2, APOH, SERPINC1, PROS1, F3, MTHFR
17lupus erythematosus29.7F2, APOH, SERPINC1, PROS1, F3, F5
18myocardial infarction29.7PLAT, SERPINF2, F3, MTHFR, F8, SERPINC1
19antithrombin iii deficiency29.7F5, MTHFR, PROS1, SERPINC1, APOH, F2
20systemic lupus erythematosus29.7F8, F3, CRP, F2, APOH
21coronary artery disease29.6PLAT, MTHFR, F3, CRP
22thrombocytosis29.6SERPINF2, CRP, F3, EPO, SERPINC1, F2
23vascular disease29.5MTHFR, APOH, F5, CRP, F3, PLAT
24hypertension29.5TGFB1, F2, PROS1, CRP, MTHFR, PLAT
25thrombophilia29.4F2, APOH, SERPINF2, SERPINC1, PROC, PROS1
26thrombophlebitis migrans10.7
27appendicitis10.4
28femoral vein thrombophlebitis10.3
29cerebritis10.3
30varicose veins10.3
31lemierre's syndrome10.3
32diverticulitis10.2
33sinusitis10.2
34blindness10.2
35thromboangiitis obliterans10.2
36hepatitis10.2
37pancreatitis10.1
38retinal artery occlusion10.1APOH
39branch retinal artery occlusion10.1F5
40hepatic vein thrombosis10.1PROS1
41hypersplenism10.1F2
42cardiac tamponade10.1F8
43chickenpox10.1PROS1
44carotid artery thrombosis10.1F3
45sneddon syndrome10.1APOH, SERPINC1
46patent foramen ovale10.1F5
47central retinal artery occlusion10.1PLAT
48meningococcemia10.1SERPINC1, F5
49retinal vascular occlusion10.1F5, APOH
50combined factor v and viii deficiency10.1F8, F5

Graphical network of the top 20 diseases related to Thrombophlebitis:



Diseases related to thrombophlebitis

Symptoms for Thrombophlebitis

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Drugs & Therapeutics for Thrombophlebitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Thrombophlebitis

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Anatomical Context for Thrombophlebitis

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34MalaCards
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MalaCards organs/tissues related to Thrombophlebitis:

34
Lung, Breast, Myeloid, Liver, Tongue, Endothelial, Testes, Prostate, Placenta, Skin, Bone, Pancreas, Colon, Heart, Retina, Brain, Pituitary

Animal Models for Thrombophlebitis or affiliated genes

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38MGI
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Publications for Thrombophlebitis

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53PubMed
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Articles related to Thrombophlebitis:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Septic thrombophlebitis of the superior mesenteric vein: an unusual complication of appendicitis. (23317599)
2013
2
Jugular thrombophlebitis in horses: a review of fibrinolysis, thrombus formation, and clinical management. (23814304)
2013
3
Treatment for superficial thrombophlebitis of the leg. (23633322)
2013
4
Candidal thrombophlebitis of central veins: case report and review. (21905947)
2012
5
Treatment of superficial thrombophlebitis. (21268737)
2011
6
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. (20881312)
2011
7
Complete visual recovery after mycotic aneurysm embolization complicated by cavernous sinus thrombophlebitis. (21052516)
2010
8
Title Page - thrombophlebitis - what else? (20703969)
2010
9
Postpartum ovarian vein thrombophlebitis: Report of a case and review of the literature. (22737678)
2010
10
Thrombolytic therapy for management of complicated catheter-related Candida albicans thrombophlebitis. (19290985)
2009
11
Extended septic thrombophlebitis in a patient with duplicated inferior vena cava: case report and review of literature. (19174747)
2009
12
Prevalence of deep vein thrombosis and pulmonary embolism in superficial thrombophlebitis of the lower limbs: prospective study of 60 cases. (19935595)
2009
13
Treating superficial venous thrombophlebitis. (18926088)
2008
14
Successful stem cell transplantation without cryopreservation from a microchimeric haploidentical sibling for refractory acute myeloid leukemia complicated with critical thrombophlebitis and cellulitis. (17261507)
2007
15
Clinical inquiries. What is the best therapy for superficial thrombophlebitis? (15251103)
2004
16
A hematogenic pleuropneumonia caused by postoperative septic thrombophlebitis in a Thoroughbred gelding. (15028889)
2004
17
Radiology quiz case 1. Childhood cavernous sinus thrombophlebitis. (15023852)
2004
18
Deep septic thrombophlebitis: an unrecognized cause of relapsing bacteremia in patients with cancer. (15084634)
2004
19
Superior mesenteric thrombophlebitis subsequent to acute appendicitis in an adult. (12767025)
2003
20
Simultaneous ultrasound identification of acute appendicitis, septic thrombophlebitis of the portal vein and pyogenic liver abscess. (12916378)
2003
21
Neuro-BehAset's disease (isolated cerebral thrombophlebitis excluded). Clinical pattern, prognostic factors, treatment and long term follow-up. (12918726)
2003
22
Superficial thrombophlebitis followed by pulmonary embolism. (11418716)
2001
23
Oropharyngeal Necrobacillosis with Septic Thrombophlebitis and Pulmonary Embolic Abscesses: Lemierre's Syndrome in a New Zealand White Rabbit. (12086416)
1999
24
Imaging of puerperal septic thrombophlebitis: primary role for sonography. (9574625)
1998
25
Ultrasonographic investigation of the pathogenesis of infusion thrombophlebitis. (9171751)
1997
26
Thrombophlebitis and varicosis syndrome in pregnancy. (9107455)
1997
27
Septic thrombophlebitis of the inferior mesenteric vein associated with diverticulitis CT diagnosis. (8744820)
1996
28
Septic pelvic thrombophlebitis or refractory postpartum fever of undetermined etiology. (8972414)
1996
29
Suppurative thrombophlebitis. (7551490)
1995
30
Superficial thrombophlebitis of the breast (Mondor's disease): mammographic findings. (8498215)
1993
31
Development of thrombophlebitis in peripheral veins with Vialon and PTFE-Teflon cannulas: a double-blind, randomised, controlled trial. (1929137)
1991
32
Concurrent existence of heterotopic ossification and thrombophlebitis. (2106785)
1990
33
Deep vein thrombophlebitis of a leg in a young female with heterozygous protein C deficiency taking oral contraceptives. (1703114)
1990
34
Superficial migratory thrombophlebitis and factor XII deficiency. (2110579)
1990
35
Surgical management of fungal peripheral thrombophlebitis. (2928953)
1989
36
Deep vein thrombophlebitis and pulmonary embolism in patients with malignant gliomas. (2814622)
1989
37
Infusion thrombophlebitis--histological and bacteriological study. (2628322)
1989
38
Obesity: is it really a risk factor in thrombophlebitis? (3310249)
1987
39
Puerperal pelvic thrombophlebitis: impact on diagnosis and treatment using x-ray computed tomography and magnetic resonance imaging. (3785791)
1986
40
Thrombophlebitis and septicemia--complications related to intravascular devices and their prophylaxis. A review. (3524089)
1986
41
Deep venous thrombosis, pulmonary embolism and acute surgery in thrombophlebitis of the long saphenous vein. (4013602)
1985
42
Calf hematoma mimicking thrombophlebitis: sonographic and computed tomographic appearance. (3969483)
1985
43
Ovarian vein thrombophlebitis: diagnosis by ultrasound and CT. (6429210)
1984
44
Deep venous thrombophlebitis associated with lithium toxicity. (6431115)
1984
45
Thrombophlebitis in BehAset's disease: two causes of diagnostic error. (6732889)
1984
46
Thrombophlebitis migrans. An unusual presentation as a collagen vascular disease--report of a case. (4147715)
1973
47
Fulminating thrombophlebitis migrans. (13118959)
1954
48
Thrombophlebitis migrans; report of a case. (18136551)
1949
49
Antihistamine therapy in thrombophlebitis migrans; a case report. (18117633)
1949
50
The ambulatory treatment of phlebitis, thrombophlebitis, and thrombosis with compression bandages. (20240252)
1947

Variations for Thrombophlebitis

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Expression for genes affiliated with Thrombophlebitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thrombophlebitis

Search GEO for disease gene expression data for Thrombophlebitis.

Pathways for genes affiliated with Thrombophlebitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 52PharmGKB, 13EMD Millipore, 54QIAGEN, 31KEGG, 55R&D Systems
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Pathways related to Thrombophlebitis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SERPINC1, TGFB1
29.6PLAT, SERPINF2
3
Show member pathways
9.4F2, PROC, PROS1
4
Show member pathways
9.4PROS1, PROC, F2
58.9CRP, F8, PROC, APOH
6
Show member pathways
8.8TGFB1, SERPINF2, PROS1, F8, F5
7
Show member pathways
8.2F2, SERPINC1, PROC, PROS1, F3, F8
8
Show member pathways
thioredoxin pathway39
8.2F2, MTHFR, PLAT, CRP
9
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
7.3F5, PLAT, F8, F3, PROS1, PROC
10
Show member pathways
7.3SERPINC1, SERPINF2, F2, PROC, PROS1, F3
11
Show member pathways
6.8F5, PLAT, F8, F3, PROS1, PROC

Compounds for genes affiliated with Thrombophlebitis

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 25HMDB
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Compounds related to Thrombophlebitis according to GeneCards/GeneDecks:

(show top 50)    (show all 205)
idCompoundScoreTop Affiliating Genes
1inogatran469.5F3, F2, F5, SERPINC1
2ecarin469.5SERPINC1, F2, F3, F5
3danaparoid469.4F2, SERPINC1, F3, F5
4ximelagatran46 1210.4F2, F3, SERPINC1, F5
5heparinoids469.4F5, F3, SERPINC1, F2
6kaolin469.3F8, F3, F5, F2, APOH
7coumarins469.3APOH, F3, F5, F2
8hydroxyethyl starch469.3F3, SERPINC1, F8, F2
9cardiolipin46 1210.2F2, APOH, F3, F8, F5
10gamma-carboxyglutamic acid469.2F5, F3, PROS1, PROC, F2
11ancrod469.2SERPINC1, F5, PLAT, F2
12fibrinopeptide a469.1F2, PLAT, SERPINC1, SERPINF2
13spectrozyme468.9F2, SERPINC1, F3, PLAT, F5
14fondaparinux468.9PLAT, SERPINC1, F2, F5, F3
15bivalirudin46 129.9F2, F5, PLAT, F3, SERPINC1
16argatroban46 129.9F2, F5, PLAT, F3, SERPINC1
17protamine sulfate468.9PLAT, F2, F5, F3, SERPINC1
18levonorgestrel46 62 30 1211.9F2, SERPINC1, PLAT, F3, F5
19protamine468.7F2, F5, F3, SERPINC1, PLAT
20dermatan sulfate468.7SERPINC1, F2, F5, F3, PLAT
21phospholipid468.5F2, APOH, F5, F3, PROC, F8
22ppack468.4SERPINC1, F3, F2, PLAT
23tranexamic acid46 129.4F2, PLAT, F8, F3, EPO, SERPINC1
24kininogen468.4SERPINC1, F2, APOH, SERPINF2, F3, F5
25hirudin468.4F5, PLAT, F3, SERPINC1, SERPINF2, F2
26gabexate mesilate468.4CRP, PLAT, SERPINC1, F5
27epsilon aminocaproic acid468.4F2, PLAT, SERPINF2, SERPINC1, F3, EPO
28tirofiban46 129.3F2, SERPINC1, PLAT, CRP, F3
29abciximab46 129.3PLAT, F2, CRP, SERPINC1, F3
30polyethylene glycol468.2TGFB1, F8, CRP, SERPINC1, F5, F2
31endotoxin468.2F8, SERPINF2, F3, F5, APOH, CRP
32clopidogrel46 52 25 1211.2F2, F3, SERPINC1, CRP, PLAT
33cyclophosphamide46 52 1210.1F8, F5, F3, MTHFR, APOH, CRP
34aprotinin46 129.1EPO, F3, SERPINC1, F2, F5, PLAT
35citrate467.9SERPINC1, CRP, F5, F8, F2, F3
36folate467.9MTHFR, SERPINC1, EPO, F5, CRP, APOH
37desmopressin46 62 30 1210.8F5, PLAT, F8, F3, EPO, SERPINC1
38ristocetin467.8F2, SERPINF2, F5, PLAT, F8, F3
39warfarin46 52 25 1210.7F5, F8, MTHFR, F3, PROC, SERPINC1
40prostacyclin467.6CRP, PLAT, F5, PROS1, SERPINC1, F3
41cholesterol46 30 25 1210.4MTHFR, APOH, PROS1, PLAT, SERPINF2, F8
42homocysteine46 258.2F5, CRP, PLAT, F8, MTHFR, F3
43alanine467.1F2, CRP, TGFB1, F8, MTHFR, SERPINC1
44aspartate467.1F3, MTHFR, F8, PLAT, EPO, F5
45heparin46 30 25 1210.0PROS1, F2, APOH, SERPINF2, SERPINC1, PROC
46vegf466.9TGFB1, F3, PROS1, F8, CRP, F5
47serine466.7SERPINF2, SERPINC1, PROC, TGFB1, PLAT, F8
48aspirin46 52 30 259.6APOH, F2, TGFB1, SERPINC1, F5, CRP
49fibrinogen466.6F2, F5, CRP, PLAT, F8, F3
50creatinine465.8F5, CRP, PLAT, F8, MTHFR, F3

GO Terms for genes affiliated with Thrombophlebitis

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17Gene Ontology
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Cellular components related to Thrombophlebitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310128.9PLAT, F3, APOH
2platelet alpha granule lumenGO:0310938.9TGFB1, SERPINF2, PROS1, F8, F5
3Golgi lumenGO:0057968.8F2, TGFB1, PROC, PROS1
4blood microparticleGO:0725628.6F2, TGFB1, SERPINF2, SERPINC1, PROS1
5plasma membraneGO:0058868.0TGFB1, SERPINC1, PROC, F3, F8, F5
6cell surfaceGO:0099867.9APOH, TGFB1, SERPINF2, EPO, F3, PLAT
7extracellular spaceGO:0056156.0F5, F2, APOH, TGFB1, SERPINF2, SERPINC1
8extracellular regionGO:0055766.0SERPINC1, SERPINF2, TGFB1, F2, EPO, PROC

Biological processes related to Thrombophlebitis according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of blood coagulationGO:03019510.0APOH, PROC
2positive regulation of blood coagulationGO:0301949.9APOH, F2
3blood coagulation, intrinsic pathwayGO:0075979.8F2, APOH, F8
4negative regulation of fibrinolysisGO:0519189.8SERPINF2, APOH, F2
5plasminogen activationGO:0316399.8PLAT, APOH
6peptidyl-glutamic acid carboxylationGO:0171879.7PROS1, PROC, F2
7negative regulation of endopeptidase activityGO:0109519.7SERPINF2, SERPINC1, PROS1
8leukocyte migrationGO:0509009.6F2, PROC, PROS1
9positive regulation of collagen biosynthetic processGO:0329679.5SERPINF2, TGFB1, F2
10response to interleukin-1GO:0705559.5MTHFR, EPO
11blood circulationGO:0080159.5EPO, MTHFR, F5
12negative regulation of proteolysisGO:0458619.3PLAT, F2
13post-translational protein modificationGO:0436879.1PROS1, PROC, F2
14fibrinolysisGO:0427309.1F2, SERPINF2, PROS1, PLAT
15platelet degranulationGO:0025769.1TGFB1, SERPINF2, PROS1, F8, F5
16proteolysisGO:0065089.0PLAT, PROS1, PROC, F2
17acute-phase responseGO:0069539.0F2, SERPINF2, F8, CRP
18agingGO:0075688.8CRP, EPO, TGFB1
19platelet activationGO:0301688.7F2, TGFB1, SERPINF2, PROS1, F8, F5
20response to hypoxiaGO:0016668.3CRP, PLAT, MTHFR, TGFB1
21blood coagulationGO:0075967.1F5, F2, TGFB1, SERPINF2, SERPINC1, PROC

Molecular functions related to Thrombophlebitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.8PROS1, SERPINF2
2protease bindingGO:0020209.2F3, SERPINC1, SERPINF2
3serine-type endopeptidase activityGO:0042528.6F5, PLAT, F8, PROC, F2
4protein bindingGO:0055155.4SERPINC1, SERPINF2, TGFB1, APOH, F2, EPO

Products for genes affiliated with Thrombophlebitis

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Sources for Thrombophlebitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet