Thrombosis malady

Wikipedia: Thrombosis (Greek: θρόμβωσις) is the formation of a blood clot (thrombus; Greek:...⁴⁴ more...

MalaCards: Thrombosis is related to venous thrombosis and deep vein thrombosis. An important gene associated with Thrombosis is F2 (coagulation factor II (thrombin)), and among its related pathways are Complement and coagulation cascades and Blood Coagulation Signaling Pathways. The drug pentoxifylline and the compounds calcium and atp have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

OMIM: 188050

thrombosis 7 33 32 43

Diseases related to thrombosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 964)

id	Related Disease	Score	Top Affiliating Genes
1	venous thrombosis	47.0	LRP1, VWF, SELP, SELPLG, SERPINC1, SERPINA5
2	deep vein thrombosis	46.3	VWF, SELP, SERPINC1, SERPINE1, VKORC1, MTRR
3	thrombophilia	42.7	PIGA, VWF, SELE, SELP, SERPINC1, SERPINF2
4	antiphospholipid syndrome	40.8	VWF, SELE, SELP, SELPLG, SERPINC1, SERPINE1
5	portal vein thrombosis	39.6	REN, PCNA, SELP, SERPINC1, SERPINE1, VKORC1
6	myocardial infarction	39.3	PIK3C2A, PIK3CG, LRP1, LRPAP1, COG2, RECK
7	thromboembolism	39.2	LRP1, VWF, SELP, SERPINC1, SERPINF2, SERPIND1
8	carcinoma	39.0	PIK3C2A, PIK3CG, LRP1, LRPAP1, RFC1, PDE3A
9	cerebritis	39.0	PIK3C2A, PIK3CG, LRP1, COG2, REN, VWF
10	heparin-induced thrombocytopenia	38.1	SELE, SELP, SERPINC1, SERPINE1, MTHFR, AZU1
11	atherosclerosis	37.8	PIK3C2A, PIK3CG, LRP1, LRPAP1, COG2, RECK
12	pulmonary embolism	37.6	PIK3C2A, SERPINC1, SERPINA5, SERPINF2, SERPINE1, VKORC1
13	systemic lupus erythematosus	37.2	RECK, VWF, VTN, SELE, VCAM1, CFH
14	thrombocytopenia	36.9	PIGA, PIK3C2A, RECK, VWF, SELE, SELL
15	protein c deficiency	36.9	SERPINC1, SERPINF2, SERPIND1, SERPINA10, SERPINE1, MTHFR
16	protein s deficiency	36.6	PIGA, PIK3C2A, LRP1, RECK, SERPINC1, SERPINE1
17	coronary thrombosis	36.2	VWF, SERPINC1, SERPINE1, P2RY12, ITGB3, FGA
18	antithrombin iii deficiency	35.3	SERPINC1, SERPIND1, MTHFR, JAK2, FGA, APOH
19	polycythemia vera	35.0	PIK3CG, VWF, SELP, SERPINC1, SERPINE1, MPL
20	polycythemia	34.7	PIK3CG, VWF, SELP, SERPINC1, SERPINE1, VHL
21	hyperhomocysteinemia	34.7	VWF, SELE, SELP, SERPINC1, SERPINE1, LPA
22	essential thrombocythemia	34.5	VWF, SELP, MPL, JAK2, CD177, IL3
23	leukemia	34.3	PIGA, PIK3C2A, PIK3CG, LRP1, LRPAP1, COG2
24	factor v leiden thrombophilia	34.1	VWF, SERPINC1, SERPINF2, SERPINA1, SERPINE1, VKORC1
25	lupus erythematosus	33.9	PIK3C2A, PIK3CG, COG2, RECK, RETN, VWF
26	hepatitis	33.9	SELP, SERPINA1, XDH, IL2RB, GPT, IFNA1
27	liver cirrhosis	33.8	REN, RETN, VTN, SERPINC1, SERPINF2, SERPINB2
28	carotid artery thrombosis	33.6	COG2, GCNT2, SERPINC1, SERPINE1, P2RY12, F3
29	acute myocardial infarction	33.3	PIK3C2A, PIK3CG, COG2, REN, RETN, VWF
30	myeloproliferative disorder	33.2	VWF, SELP, AXL, MPL, MPO, JAK2
31	dysfibrinogenemia	33.2	SERPINC1, SERPIND1, FGA, FGB, FGG, F5
32	ischemia	33.0	PIK3C2A, PIK3CG, COG2, REN, RETN, VWF
33	hypertension	33.0	PIK3C2A, PIK3CG, LRP1, COG2, RFC1, PDE3A
34	hepatic vein thrombosis	32.9	PIGA, SERPINE1, UBN1, MTHFR, JAK2, F5
35	disseminated intravascular coagulation	32.8	PIK3C2A, VWF, VTN, SELE, SERPINC1, SERPINA5
36	von willebrand's disease	32.8	VWF, SELP, ITGA2B, GP1BA, F9, F8
37	thrombocytosis	32.8	VWF, SELP, SERPINC1, SERPINF2, VEGFA, MTHFR
38	sepsis	32.7	RECK, RETN, VTN, SELE, SELL, SELP
39	pulmonary hypertension	32.6	PIK3CG, SETD2, FLT1, FGA, HTR3A, PTGIS
40	coronary heart disease	32.5	PIK3C2A, LRP1, COG2, RETN, VWF, SELE
41	homocysteine	32.4	PIK3C2A, COG2, RFC1, REN, RETN, VWF
42	factor xii deficiency	32.4	VWF, SERPINC1, APOH, F9, F8, F5
43	intracranial thrombosis	32.3	SERPINC1, ITGA2B, F5, F2, F10, PLAT
44	vascular disease	32.1	LRP1, RECK, RETN, VWF, VTN, SELE
45	hemoglobinuria	32.0	PIGA, PIK3C2A, RECK, VWF, SELL, SELP
46	sinusitis	32.0	VWF, PCNA, SELL, SELP, SERPINC1, SERPINE1
47	behcet's disease	31.8	SELE, SELL, SAG, MEFV, IL18, IL8
48	endocarditis	31.8	PIK3C2A, VWF, SELE, SERPINC1, SERPINA1, VCAM1
49	homocystinuria	31.6	SERPINC1, MTRR, MTHFR, MTR, CD36, F8
50	hemophilia	31.5	VWF, SELP, SELPLG, SERPINC1, MTHFR, CD40LG

Clinical features from OMIM: 188050

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 pentoxifylline

MalaCards organs/tissues related to thrombosis:

²²

MGI Mouse Phenotypes related to thrombosis:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	14.1	PIK3C2A, PIK3CG, LRP1, LRPAP1, REN, RETN
2	mortality/aging	MP:0010768	13.7	PIGA, PIK3C2A, LRP1, LRPAP1, RECK, REN
3	hematopoietic system phenotype	MP:0005397	12.8	PIGA, PCNA, GCNT2, SERPIND1, SERPINB2, VHL
4	immune system phenotype	MP:0005387	12.3	LRP1, REN, VWF, GCNT2, SELL, SELP
5	normal phenotype	MP:0002873	11.8	LRP1, LRPAP1, PDE3A, REN, VTN, SELE
6	respiratory system phenotype	MP:0005388	11.5	SELL, SELP, UTRN, LEPR, UCP2, CD14
7	nervous system phenotype	MP:0003631	11.2	PIGA, LRP1, LRPAP1, RECK, REN, VWF
8	integument phenotype	MP:0010771	11.2	PIGA, PIK3CG, RECK, GCNT2, SELP, SELPLG
9	growth/size phenotype	MP:0005378	10.8	PIGA, PIK3C2A, PIK3CG, LRP1, RECK, REN
10	endocrine/exocrine gland phenotype	MP:0005379	10.6	LRPAP1, SELL, SERPINA5, PAFAH1B1, LDLR, XDH
11	cardiovascular system phenotype	MP:0005385	10.6	PIK3CG, LRP1, RECK, REN, VWF, SELE
12	embryogenesis phenotype	MP:0005380	10.4	PIGA, RECK, SERPINC1, SETD2, VHL, MPL
13	other phenotype	MP:0005395	10.3	LRPAP1, RECK, VASP, RARA, LEPR, LDLR
14	skeleton phenotype	MP:0005390	10.0	PIGA, PIK3CG, LRP1, RECK, VHL, VEGFA
15	renal/urinary system phenotype	MP:0005367	9.8	LRPAP1, REN, GCNT2, SELP, SELPLG, SERPIND1
16	reproductive system phenotype	MP:0005389	9.7	PIGA, LRPAP1, PDE3A, REN, SERPINA5, SERPINF1
17	cellular phenotype	MP:0005384	9.4	PIGA, PIK3CG, VWF, PCNA, SELE, SELL
18	limbs/digits/tail phenotype	MP:0005371	8.8	RECK, VHL, VEGFA, RARA, UTRN, LEP
19	liver/biliary system phenotype	MP:0005370	8.8	RECK, RETN, SERPINC1, VHL, VEGFA, UTRN
20	behavior/neurological phenotype	MP:0005386	8.7	PIGA, LRP1, REN, GCNT2, SELE, SELP
21	digestive/alimentary phenotype	MP:0005381	8.5	PIGA, VWF, SERPINF1, VHL, VEGFA, RARA
22	vision/eye phenotype	MP:0005391	8.0	SELE, SELP, SERPINC1, SERPINF1, VEGFA, RARA
23	muscle phenotype	MP:0005369	7.7	PIK3CG, LRP1, REN, SERPIND1, SERPINB2, VHL
24	tumorigenesis	MP:0002006	7.5	PIGA, SELL, SERPINE1, VHL, RARA, LEP
25	adipose tissue phenotype	MP:0005375	7.5	PIK3C2A, LRP1, RETN, SERPINE1, LEP, LEPR

Articles related to thrombosis:

(show top 50)    (show all 2020)

id	Title	Authors	Year	Affiliating Genes
1	High plasma interleukin-6 is associated with drug-elu ting stent thrombosis: possible role of inflammatory cytokines in the developme nt of stent thrombosis from the Korea Stent Thrombosis Registry. (21498913)	Hwang S.J.... Kim H.S.	2011	IL6
2	Prenatal ductal thrombosis presenting as cyanotic hea rt lesion. (21956152)	Nyp M.F.... Kilbride H.	2011	MTHFR
3	Thrombosis in myelofibrosis: prior thrombosis is the only predictive factor and most venous events are provoked. (20884719)	Elliott M.A.... Tefferi A.	2010	JAK2
4	Accumulation of gene polymorphisms related to plaque disruption and thrombosis is associated with cerebral infarction in subjects wi th type 2 diabetes. (19933990)	Katakami N.... Yamasaki Y.	2010	VWF, SERPINE1, MMP9
5	Two new examples of Hb St. Etienne [beta 92(F8)HisGln ] in association with venous thrombosis. (19373584)	Au N.H.... Wadsworth L.D.	2009	HBB
6	Deep venous thrombosis and previous myocardial infarction in mild factor XII deficiency: a risk factor for both venous and arterial thrombosis. (18392695)	Lessiani G.... DavA- G.	2009	F3
7	Residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis: a randomized trial. (19414836)	Prandoni P.... Agnelli G.	2009	F2
8	Cerebral Venous and Sinus Thrombosis and Thrombophili c Mutations in Western Iran: Association With Factor V Leiden. (19703820)	Rahimi Z.... Rezaei M.	2009	F2, F5, MTHFR
9	Leukocytosis is linked to thrombosis at diagnosis, while JAK2 V617F mutation is associated with thrombosis during the course of essential thrombocythemia. (18409076)	Ohyashiki K.... Ohyashiki J.H.	2008	JAK2
10	Increased expression of CD44s in conventional renal cell carcinomas with renal vein or vena cava thrombosis. a retrospective evaluation of the expression of CD44s by immunohistochemical analysis in conventional RCC patients and in conventional RCC patients with renal vein or vena cava thrombosis. (19077409)	Altinel M.... Yazicioglu A.	2008	CD44
11	IgG antibodies to plasminogen and their relationship to IgG anti-beta(2)-glycoprotein 1 antibodies and thrombosis. (17646899)	Bu C.... Cai G.	2008	PLG
12	The impact of JAK2 and MPL mutations on diagnosis and prognosis of splanchnic vein thrombosis: a report on 241 cases. (18250227)	Kiladjian J.J.... Valla D.C.	2008	JAK2, MPL
13	Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study. (17576867)	Agnelli G.... Schellong S.	2007	F10
14	Risk of vascular access thrombosis in patients with s ystemic lupus erythematosus on hemodialysis. (17534796)	Shafi S.T.... Gupta M.	2007	APOH
15	Ischaemic stroke, factor V Leiden heterozygosity and left atrial thrombosis in sinus rhythm: a case report. (17464477)	Imperiale D.... Buffa C.	2007	F5
16	Prothrombin G20210A gene variant is not associated with idiopathic portal vein thrombosis in an area endemic for portal vein thrombosis. (16283309)	Koshy A.... Jeyakumari M.	2006	F2
17	Recurrent thrombosis in patients with deep vein thrombosis and/or venous thromboembolism associated with anticardiolipin antibodies. (16444460)	de Godoy J.M.... BRAILE D.M.	2006	APOH
18	Splenic marginal zone lymphoma, iliac vein thrombosis, and monoclonal immunoglobulin Mkappa antiphospholipid antibody with Annexin A5 interaction. (17065025)	Martin S.E.... Abel R.F.	2006	ANXA5
19	Thrombophilia and thrombosis (16296580)	ObradoviA8 D.	2005	F5
20	Pregnancy-associated deep vein thrombosis in a double homozygous carrier of factor V Leiden and prothrombin G20210A. (16411414)	Beretta A.L.... Martinelli I.	2005	F5
21	Antiphospholipid antibodies and thrombosis: associati on with acquired activated protein C resistance in venous thrombosis and with h yperhomocysteinemia in arterial thrombosis. (15583739)	Kassis J.... Fortin P.R.	2004	F5
22	The angiotensin-converting-enzyme insertion/deletion polymorphism is not related to venous thrombosis. (14691571)	Koppel H.... Pilger E.	2004	ACE
23	Apolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting. (15466371)	Koch W.... Kastrati A.	2004	APOE
24	Deep vein thrombosis followed by internal jugular vein thrombosis as a complication of in vitro fertilization in a woman heterozygous for the prothrombin 3' UTR and factor V Leiden mutations. (12879433)	McGowan B.M.... Perry D.J.	2003	F2, F5
25	Factor V I359T: a novel mutation associated with thrombosis and resistance to activated protein C. (14617013)	Mumford A.D.... Bolton-Maggs P.H.B.	2003	F5
26	Fatal dural sinus thrombosis associated with heterozygous factor V Leiden and a short activated partial thromboplastin time. (14521455)	Stephan C.L.... Cunningham M.T.	2003	F5
27	Risk of thrombosis associated with oral contraceptives of women from 97 families with inherited thrombophilia: high risk of thrombosis in carriers of the G20210A mutation of the prothrombin gene. (11532625)	Santamaria A.... Fontcuberta J.	2001	F2, SERPINC1, F5
28	Antithrombin deficiency in Brazilian patients with venous thrombosis: molecular characterization of a single splice site mutation, an insertion and a de novo point mutation. (11755949)	Arnaldi L.A.... Annichino-Bizzacchi J.M.	2001	SERPINC1, F12, MTHFR
29	Combined genetic defect (homogeneity for factor V Lei den and heterogeneity for prothrombin G20210A allele), in a young patient, with recurrent deep vein thrombosis and serious postphlebitic syndrome--a case repo rt. (10779003)	Mitsis M.... Vartholomatos G.	2000	F5
30	Acquired APC resistance in neurosurgical patients may not be a risk factor for postoperative deep vein thrombosis. (10725989)	Meinardi J.R.... van der Meer J.	1999	F5
31	Occurrence of thrombosis and haemorrhage, relationshi p with anti-Xa, anti-IIa activities, and D-dimer plasma levels in patients rece iving a low molecular weight heparin, enoxaparin or tinzaparin, to prevent deep vein thrombosis after hip surgery. (10050702)	Bara L.... Samama M.M.	1999	F3
32	Primary antiphospholipid syndrome: a cause of catastrophic shunt thrombosis in the newborn. (10350114)	Deally C.... Odim J.	1999	SERPINC1
33	A patient homozygous for mutation 20210A in the prothrombin gene with venous thrombosis and transient ischemic attacks of thrombotic origin. (9864932)	GonzA!lez OrdA^A+ez A.J.... Coto GarcA-a E.	1998	F2
34	Case-control study of risk of cerebral sinus thrombosis in oral contraceptive users and in [correction of who are] carriers of hereditary prothrombotic conditions. The Cerebral Venous Sinus Thrombosis Study Group. (9518910)	de Bruijn S.F.... Vandenbroucke J.P.	1998	SERPINC1, F5
35	Coronary thrombosis and the platelet glycoprotein IIIA gene PLA2 polymorphism. (9716140)	Durante-Mangoni E.... Tuddenham E.G.	1998	POU2F3
36	Guidelines for management of left-sided prosthetic va lve thrombosis: a role for thrombolytic therapy. Consensus Conference on Prosth etic Valve Thrombosis. (9362411)	Lengyel M.... Turpie A.G.	1997	F3
37	The mutation Ala677-->Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis. (9184384)	Arruda V.R.... Costa F.F.	1997	SERPINC1, F5, MTHFR
38	The antithrombotic effect of synthetic low molecular weight human factor Xa inhibitor, DX-9065a, on He-Ne laser-induced thrombosis in rat mesenteric microvessels. (8983124)	Yamashita T.... Yamamoto J.	1997	F10
39	A novel thrombomodulin gene mutation in a patient suffering from sagittal sinus thrombosis. (9364978)	Norlund L.... Ohlin A.K.	1997	F5
40	Comparison of desulfatohirudin (REVASC) and heparin as adjuncts to thrombolytic therapy with reteplase in a canine model of coronary thrombosis. (8735626)	Martin U.... Fischer S.	1996	PLAT, F3
41	Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis. (1443986)	Ginsburg K.S.... Stampfer M.J.	1992	APOH
42	Hematological causes of venous thrombosis in young people: high incidence of myeloproliferative disorder as underlying disease in patients with splanchnic venous thrombosis. (1641818)	Teofili L.... Bizzi B.	1992	EPO
43	Prophylaxis of thrombosis in a pregnant woman with congenital antithrombin III deficiency: changes in hemostatic molecular markers before the onset of thrombosis (1433937)	Inomoto T.... Sigekiyo T.	1992	FGA
44	Double-blind, randomized comparison of systemic conti nuous infusion of 0.25 versus 0.50 mg/kg/24 h of alteplase over 3 to 7 days for treatment of deep venous thrombosis in heparinized patients: results of the Eu ropean Thrombolysis with rt-PA in Venous Thrombosis (ETTT) trial. (1641820)	Bounameaux H.... Schneider P.A.	1992	PLAT
45	A search for autoantibodies to thrombomodulin in patients with documented thrombosis. (1333100)	Nelson M.... Kronenberg H.	1992	THBD
46	Deep venous thrombosis and pulmonary embolism in a patient with type III von Willebrand's disease, protein C and antithrombin III deficiency. (1390220)	Bowen D.... Bloom A.	1992	SERPINC1
47	Hemostatic changes in idiopathic venous thrombosis in childhood and adolescence (1758145)	Nowak-Gottl U.... Kornhuber B.	1991	SERPINC1, SERPINF2, SERPINA3
48	Haemostatic factors associated with vascular thrombosis in patients with systemic lupus erythematosus and the lupus anticoagulant. (1909517)	Mayumi T.... Niho Y.	1991	FGA
49	Association between plasma levels of tissue plasminog en activator and postoperative deep vein thrombosis--influence of prophylaxis w ith a low molecular weight heparin. The Venous Thrombosis Group. (2169077)	SA... Neerstrand H.S.	1990	PLAT
50	Prevention of platelet-rich arterial thrombosis by se lective thrombin inhibition. (2297828)	Jang I.K.... Collen D.	1990	F3

Genes related to thrombosis according to GeneCards:

(show top 50)    (show all 377)

id	Symbol	Description	Score	GeneCards Section Context
1	F2	coagulation factor II (thrombin)	11.1	Summaries, Publications
2	PLAT	plasminogen activator, tissue	11.1	Publications, Summaries
3	SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	11.1	Publications, Summaries
4	CTEPH1	Pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis, susceptibility to	11.1	Aliases & Descriptions
5	PROC	protein C (inactivator of coagulation factors Va and VIIIa)	11.1	Publications, Summaries
6	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.0	Publications, Summaries
7	SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	11.0	Summaries, Publications
8	GAS6	growth arrest-specific 6	11.0	Publications, Summaries
9	F2RL2	coagulation factor II (thrombin) receptor-like 2	11.0	Summaries, Publications
10	CD59	CD59 molecule, complement regulatory protein	11.0	Summaries
11	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
12	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
13	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
14	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
15	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
16	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
17	F8	coagulation factor VIII, procoagulant component	11.0	Publications
18	FGA	fibrinogen alpha chain	11.0	Publications
19	F10	coagulation factor X	11.0	Publications
20	VWF	von Willebrand factor	11.0	Publications
21	TNXA	tenascin XA (pseudogene)	11.0	Publications
22	PROCR	protein C receptor, endothelial	11.0	Publications
23	THBD	thrombomodulin	11.0	Functions, Publications
24	F9	coagulation factor IX	11.0	Publications
25	CBS	cystathionine-beta-synthase	11.0	Publications
26	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
27	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	11.0	Publications
28	FERMT3	fermitin family member 3	11.0	Summaries
29	F12	coagulation factor XII (Hageman factor)	11.0	Publications
30	PROS1	protein S (alpha)	11.0	Publications
31	JAK2	Janus kinase 2	11.0	Publications
32	P2RY12	purinergic receptor P2Y, G-protein coupled, 12	11.0	Publications
33	FGB	fibrinogen beta chain	11.0	Publications
34	F11	coagulation factor XI	11.0	Publications
35	SULT1A3	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3	11.0	Publications
36	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
37	TTF2	transcription termination factor, RNA polymerase II	11.0	Publications
38	F2R	coagulation factor II (thrombin) receptor	11.0	Publications
39	GP6	glycoprotein VI (platelet)	11.0	Publications
40	EPO	erythropoietin	11.0	Publications
41	PLG	plasminogen	11.0	Publications
42	MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	11.0	Publications
43	THPO	thrombopoietin	11.0	Publications
44	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications
45	PF4	platelet factor 4	11.0	Publications
46	HRG	histidine-rich glycoprotein	11.0	Publications
47	VKORC1	vitamin K epoxide reductase complex, subunit 1	11.0	Publications
48	F7	coagulation factor VII (serum prothrombin conversion accelerator)	11.0	Publications
49	ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	11.0	Publications
50	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif, 13	11.0	Publications

Pathways related to thrombosis according to GeneDecks:

(show top 50)    (show all 114)

id	Pathway	Score	Top Affiliating Genes
1	Complement and coagulation cascades20	14.5	VWF, SERPINC1, SERPINA5, SERPINF2, SERPIND1, SERPINA1
2	Blood Coagulation Signaling Pathways37	13.9	VWF, SERPINC1, SERPINA5, SERPINF2, SERPIND1, SERPINB2
3	Blood Coagulation Cascade36	12.9	SERPINC1, FGA, FGB, FGG, F9, F8
4	Intrinsic Prothrombin Activation Pathway36	12.4	SERPINC1, FGA, FGB, FGG, F9, F8
5	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	12.4	VWF, P2RX1, P2RY1, P2RY12, CD36, ITGA2
6	Extrinsic Prothrombin Activation Pathway36	12.4	SERPINC1, FGA, FGB, FGG, F7, F5
7	Cell surface interactions at the vascular wall38	12.0	SELL, SELP, SELPLG, CD177, ITGAL, ITGAM
8	Warfarin Pathway, Pharmacodynamics34	11.8	VKORC1, BGLAP, F9, F7, F2, F10
9	Glioma Invasiveness36	11.7	VTN, CD44, ITGA2B, ITGAL, ITGAM, ITGAX
10	Cell adhesion Integrin inside-out signaling10	11.7	PIK3CG, ITGA2, ITGA2B, ITGAL, ITGB2, ITGB3
11	Cell adhesion_Integrin inside-out signaling41	11.7	PIK3CG, ITGA2, ITGB3, FN1, FGA, FGB
12	UPA-UPAR Pathway36	11.6	VTN, SERPINE1, JAK2, ITGA2, ITGA2B, ITGAL
13	Staphylococcus aureus infection20	11.5	SELP, SELPLG, CFH, ITGAL, ITGAM, ITGB2
14	Actin-Based Motility by Rho Family GTPases36	11.2	ITGA2B, ITGAL, ITGAM, ITGAX, IL2, GNA11
15	Hematopoietic cell lineage20	11.1	CD36, CD14, CD59, CD44, CD55, ITGA2
16	Angiogenesis3	10.7	RECK, REN, VHL, ITGB3, MMP2, MMP9
17	Transendothelial Migration of Leukocytes36	10.7	VCAM1, ITGA2, ITGA2B, ITGAL, ITGAM, ITGAX
18	Akt Signaling36	10.7	PIK3CG, AXL, ITGA2, ITGA2B, ITGAL, ITGAM
19	ILK Signaling36	10.6	AXL, ITGAM, ITGAX, ITGB2, ITGB3, FN1
20	Tuberculosis20	10.6	CLEC4M, JAK2, CD14, ITGAM, ITGAX, ITGB2
21	Phospholipase-C Pathway36	10.3	CD79A, ITGA2, ITGA2B, ITGAL, ITGAM, ITGAX
22	MAPK Signaling36	10.3	AXL, ITGA2, ITGA2B, ITGAL, ITGAM, ITGAX
23	PTEN Pathway36	10.2	ITGA2, ITGA2B, ITGAL, ITGAM, ITGAX, ITGB2
24	Rho Family GTPases36	10.2	AXL, ITGA2, ITGA2B, ITGAL, ITGAM, ITGAX
25	Amoebiasis20	10.1	SERPINB2, CD14, ITGAM, ITGB2, FN1, IL1B
26	Estrogen Pathway36	9.8	AXL, FLT1, FGF2, MERTK, IL2, IL3
27	ERK Signaling36	9.8	AXL, ITGA2B, ITGAL, ITGAM, ITGAX, ITGB2
28	Cell adhesion ECM remodeling10	9.7	VTN, SERPINE1, CD44, MMP1, MMP14, MMP2
29	Cell adhesion_ECM remodeling41	9.7	VTN, SERPINE1, CD44, MMP1, MMP14, MMP2
30	PPAR Pathway36	9.7	ITGA2, ITGA2B, ITGAL, ITGAM, ITGAX, ITGB2
31	NFAT in Immune Response36	9.6	AXL, CD79A, FLT1, GSK3B, FGF2, MERTK
32	Molecular Mechanisms of Cancer36	9.6	PIK3CG, RARA, ITGA2, ITGA2B, ITGAL, ITGAM
33	Renin-Angiotensin Pathway36	9.6	REN, VCAM1, JAK2, FLT1, FGF2, IL2
34	African trypanosomiasis20	9.5	SELE, VCAM1, IL10, IL18, IL1B, IL6
35	Activation of PKA through GPCR36	9.3	PDE3A, VASP, AXL, FLT1, GSK3B, FGF2
36	Malaria20	9.3	LRP1, SELE, SELP, VCAM1, CD36, CD40LG
37	p70S6K Signaling36	9.2	JAK2, FLT1, INS, FGF2, IL2, IL3
38	Rheumatoid arthritis20	9.1	VEGFA, ITGAL, ITGB2, MMP1, MMP3, FLT1
39	Rac1 Pathway36	9.1	CD44, ITGA2, ITGA2B, ITGAL, ITGAM, ITGAX
40	Endothelin-1 Signaling Pathway36	9.0	AXL, FLT1, MERTK, IL10, IL18, IL1B
41	Chagas disease (American trypanosomiasis)20	9.0	PIK3CG, SERPINE1, IL10, IL1B, IL2, IL6
42	MIF Regulation of Innate Immune Cells36	8.9	CD14, IL10, IL18, IL1B, IL2, IL3
43	JAK-STAT Pathway36	8.9	AXL, MPL, JAK2, FLT1, FGF2, MERTK
44	Tec Kinases Signaling36	8.9	JAK2, ITGA2, ITGA2B, ITGAL, ITGAM, ITGAX
45	MIF Mediated Glucocorticoid Regulation36	8.8	CD14, IL10, IL18, IL1B, IL2, IL3
46	all-trans-Retinoic Acid Signaling in Brain36	8.5	RARA, IL10, IL18, IL1B, IL2, IL3
47	p38 Signaling36	8.5	AXL, FLT1, FGF2, MERTK, IL10, IL18
48	MAPK Family Pathway36	8.4	FLT1, FGF2, IL10, IL18, IL1B, IL1R1
49	Antioxidant Action of Vitamin-C36	8.3	JAK2, FLT1, FGF2, IL10, IL18, IL1B
50	Cytokine-cytokine receptor interaction20	7.4	VEGFA, LEP, LEPR, MPL, CD40LG, CD40

Compounds related to thrombosis according to GeneDecks:

(show top 50)    (show all 553)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	21.5	PIK3C2A, LRP1, LRPAP1, COG2, RECK, REN
2	atp32	14.6	PIK3C2A, RFC1, RECK, VTN, SETD2, CHGA
3	nitric oxide32 9 18 9	17.3	COG2, PDE3A, REN, RETN, SELE, SELP
4	cholesterol32 9 18 9	17.2	PIK3C2A, LRP1, LRPAP1, COG2, RECK, REN
5	adp32 18	15.1	PIK3C2A, PIK3CG, RFC1, RECK, RETN, VWF
6	thromboxane32 18	14.5	PIK3C2A, VWF, SELP, SERPINF2, VASP, P2RY12
7	histamine32 18	14.0	VWF, PCNA, SELE, SELL, SELP, SELPLG
8	ptca32	12.4	PIK3C2A, SELP, SERPINF2, CHKB, SAA4, ITGAM
9	hydrogen32 18	13.3	SELPLG, SERPINB2, RARA, CHGA, CHKB, UCP2
10	histidine32	12.1	VHL, RARA, LGALS1, CHGA, MTR, CFH
11	epsilon aminocaproic acid32	12.1	SERPINC1, SERPINF2, SERPINE1, LPA, APOB, ANXA2
12	dextran sulfate32	12.0	VTN, SELE, SELL, SELP, SERPINC1, LDLR
13	matrigel32	11.9	PIK3CG, LRP1, VWF, VTN, SELE, SERPINF1
14	cyclic amp32 18	12.9	PDE3A, SETD2, SERPINB2, VASP, CHGA, SAG
15	12-o-tetradecanoylphorbol 13-acetate32	11.8	SERPINB2, RARA, MSR1, JAK2, CD44, ITGA2
16	glucose32	11.8	SETD2, SERPINF1, VHL, LGALS1, P2RX7, ITGA2
17	verapamil32 34 9 18 9	15.7	LRP1, RECK, REN, LDLR, JAK2, FGF2
18	estradiol32 9 18 9	14.7	REN, PCNA, SERPINE1, SERPINA3, LEPR, CHKB
19	bivalirudin32 9 9	13.6	SELP, SERPINC1, MPO, FGA, F5, F3
20	p00332	11.4	COG2, RETN, SERPINA1, SERPINE1, LEP, CHGA
21	polysulfone32	11.4	VWF, SELL, SELP, VCAM1, CD14, ITGAM
22	sodium dodecylsulfate32	11.3	LRP1, VWF, VTN, SERPINF2, SERPINE1, LPA
23	acetylcholine32 9 18 9	14.2	PIK3C2A, VWF, SERPINA3, VASP, UTRN, LEP
24	silicone32	11.2	VTN, SELE, SERPINC1, CD79A, CD36, CD40LG
25	glutamine32	11.1	PIK3CG, VWF, VTN, PCNA, SERPINF2, LGALS1
26	vitamin b1232	11.1	VWF, PCNA, SERPINA3, LPA, MTRR, MTHFR
27	p00532	11.0	TNFRSF11B, TNFRSF1A, CRP, PGF, PECAM1, ADIPOQ
28	anti-fungal32	10.8	CHGA, CETP, CD79A, CD40LG, MBL2, MAPK10
29	doxorubicin32 34 9 9	13.7	PIK3C2A, PIK3CG, RECK, SELE, SETD2, CD40LG
30	cocaine32 9 9	12.6	PIK3C2A, SELE, SELP, VCAM1, LEP, LEPR
31	guanine32 9 18 9	13.5	VWF, SELE, SETD2, CHGA, LDLR, MTHFR
32	calcitriol32 42 9 18 9	14.4	REN, RARA, BGLAP, CD36, CD14, CD44
33	dapsone32 34 9 9	13.4	MPO, CD79A, IFNA2, PTGS2, PTGS1, CYP3A4
34	vitamin d32	10.4	LRP1, SERPINE1, RARA, BGLAP, LEPR, CHGA
35	nmda32 42	11.3	LRP1, LEP, LDLR, P4HB, MSR1, JAK2
36	gemfibrozil32 9 9	12.3	PIK3C2A, COG2, LPA, CHKB, LDLR, CETP
37	budesonide32 42 9 9	13.2	BGLAP, CD36, IGHE, F2RL1, PTGS1, CYP3A4
38	fenofibrate32 9 9	12.0	PIK3C2A, COG2, RETN, SELE, SELP, SERPINE1
39	ns 39832 42	10.7	PIK3CG, PCNA, BGLAP, MMP1, FGF2, IL1B
40	paraffin32	9.5	VWF, PCNA, SELL, SERPINB2, SERPINA1, SERPINA3
41	alginate32	9.3	BGLAP, CD79A, CD36, CD44, MMP14, MMP2
42	diphenyleneiodonium32	9.2	SETD2, SERPINF1, VEGFA, VCAM1, XDH, MPO
43	tacrolimus32 34 9 9	12.1	REN, VTN, PCNA, SERPINE1, CHKB, CFH
44	cisplatin32 34 9 9	12.0	PIK3C2A, VTN, PCNA, SETD2, VEGFA, BGLAP
45	glycerol32 9 18 9	11.8	PIK3C2A, VWF, PCNA, SERPINC1, LEP, CHKB
46	il-1232	8.7	CD40LG, IL10, IL18, IL1B, IL1R1, IL2
47	metformin32 34 9 9	11.6	PIK3CG, COG2, RETN, VWF, SERPINE1, LEP
48	curcumin32	8.5	PIK3CG, VTN, VEGFA, VCAM1, LDLR, JAK2
49	troglitazone32 42 9 9	11.0	PIK3CG, SELE, SERPINE1, VCAM1, RARA, LEP
50	hydrocortisone32 9 9	9.1	REN, BGLAP, MUC1, CD36, CD14, CD40

Cellular components related to thrombosis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	15.0	F10, PTGIR, PTGS1, PTPRJ, TBXA2R, OLR1
2	integral to plasma membrane	GO:005887	12.9	LRP1, SELL, SELP, SELPLG, CLEC4M, SCARA5
3	platelet alpha granule lumen	GO:031093	12.2	FGA, FGB, FGG, F8, F5, ALB
4	extracellular region	GO:005576	12.2	F2RL3, SPARC, CTSG, PPBP, NRP1, CRP
5	extracellular matrix	GO:031012	11.5	FN1, MFGE8, SERPINF1, MMP14, CFP, LGALS3BP
6	external side of plasma membrane	GO:009897	11.3	ANXA5, IFNG, ICAM1, HLA-DRB1, TNF, ACE
7	cell surface	GO:009986	10.9	AXL, CD36, CD14, CD59, CD44, CD55
8	fibrinogen complex	GO:005577	10.8	FGL2, FGB, FGA, FN1, SERPINF2, FGG
9	extracellular space	GO:005615	10.2	F11, LTA, KLKB1, C1QBP, EDN1, EGFR
10	membrane	GO:016020	10.2	VHL, IL1R1, GNG2, SERPINA5, ESR1, HLA-B
11	secretory granule	GO:030141	9.4	CHGA, MPO, INS, IL1B, HSPD1, PLAT

Biological processes related to thrombosis according to GeneDecks:

(show all 45)

id	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation	GO:007596	16.7	PIK3CG, PDE3A, VWF, SELL, SELP, SELPLG
2	platelet activation	GO:030168	14.1	PIK3CG, VWF, SELP, SERPINF2, SERPINA1, SERPINE1
3	proteolysis	GO:006508	12.7	REN, VHL, LPA, CD46, MMP1, MMP14
4	platelet degranulation	GO:002576	12.6	VWF, SELP, SERPINF2, SERPINA1, SERPINE1, VEGFA
5	leukocyte migration	GO:050900	12.3	SELL, SELP, SELPLG, CD177, ITGAL, ITGAM
6	fibrinolysis	GO:042730	12.3	SERPINF2, SERPINB2, SERPINE1, GP1BA, F2, F12
7	blood coagulation, intrinsic pathway	GO:007597	12.2	VWF, APOH, GP5, GP9, GP1BA, F9
8	cell adhesion	GO:007155	12.0	VWF, VTN, SELL, SELP, SELPLG, VCAM1
9	peptidyl-glutamic acid carboxylation	GO:017187	11.9	VKORC1, F9, F7, F2, F10, PROS1
10	negative regulation of fibrinolysis	GO:051918	11.7	SERPINF2, SERPINE1, APOH, F2, HRG, PLG
11	response to lipopolysaccharide	GO:032496	11.7	SELE, SELP, SERPINA1, P2RX7, JAK2, MMP9
12	positive regulation of blood coagulation	GO:030194	11.3	SERPINE1, CD36, APOH, F7, F2, F2R
13	leukocyte cell-cell adhesion	GO:007159	11.3	SELE, SELP, VCAM1, CLEC4M, CD40LG, ITGAL
14	innate immune response	GO:045087	11.2	PIK3CG, CLEC4M, P2RX7, AXL, CFH, CFP
15	positive regulation of angiogenesis	GO:045766	11.0	SERPINE1, VEGFA, MMP9, FLT1, FGF2, IL1B
16	regulation of complement activation	GO:030449	10.9	CFH, CFP, CD55, CD46, C4BPA, C4BPB
17	acute-phase response	GO:006953	10.9	SERPINF2, SERPINA1, SERPINA3, SAA1, SAA4, FN1
18	aging	GO:007568	10.8	SERPINF1, VCAM1, P2RY1, IL1B, AQP2, CCL2
19	negative regulation of blood coagulation	GO:030195	10.7	VTN, SERPINE1, APOE, APOH, EDN1, THBD
20	lipoprotein metabolic process	GO:042157	10.7	LPA, LDLR, P4HB, CETP, APOA1, APOB
21	extracellular matrix organization	GO:030198	10.7	RECK, P4HB, MMP1, MMP14, MMP2, MMP3
22	elevation of cytosolic calcium ion concentration	GO:007204	10.7	SAA1, P2RY1, JAK2, CD55, IL1B, IL2
23	positive regulation of macrophage derived foam cell differentiation	GO:010744	10.7	MSR1, CD36, APOB, NFKB1, PF4, AGT
24	angiogenesis	GO:001525	10.6	PIK3CG, SETD2, SERPINE1, VEGFA, MMP2, FN1
25	inflammatory response	GO:006954	10.5	PIK3CG, SELE, SELP, SERPINA3, P2RX7, AZU1
26	extracellular matrix disassembly	GO:022617	10.5	MMP1, MMP14, MMP2, MMP3, MMP9, CTSG
27	response to mechanical stimulus	GO:009612	10.4	BGLAP, P2RX7, P2RY1, MMP9, ANGPT2, CCL2
28	small molecule metabolic process	GO:044281	10.4	PIK3C2A, PIK3CG, LPA, CHKB, LDLR, UCP2
29	negative regulation of inflammatory response	GO:050728	10.3	SERPINC1, SERPINF1, SAA1, MEFV, IL2, APOA1
30	negative regulation of growth of symbiont in host	GO:044130	10.3	CD36, IL10, MBL2, IFNG, TNF, CTSG
31	immune response	GO:006955	10.3	VTN, CFP, IL18, IL1R1, IL1R2, IL1RN
32	response to glucocorticoid stimulus	GO:051384	10.2	SERPINF1, SERPINE1, BGLAP, IL10, IL1B, IL1RN
33	positive regulation of apoptotic process	GO:043065	10.2	P2RX7, JAK2, MMP9, IL1B, APC, ANXA5
34	regulation of blood pressure	GO:008217	10.2	REN, LEP, CHGA, P2RX1, GNB3, PTGS2
35	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.1	VTN, VEGFA, JAK2, CD36, CD44, ITGB3
36	signal transduction	GO:007165	9.9	RARA, LGALS1, LGALS3BP, P2RX1, AXL, JAK2
37	anti-apoptosis	GO:006916	9.9	SERPINB2, VHL, MUC1, AZU1, MPO, CD40LG
38	lipid metabolic process	GO:006629	9.8	PDE3A, LPA, LIPG, LDLR, P4HB, CETP
39	cell surface receptor signaling pathway	GO:007166	9.8	LEPR, SAG, P2RX7, P2RY1, MPL, CD36
40	response to hypoxia	GO:001666	9.6	SERPINA1, VEGFA, VCAM1, LEP, MMP9, FLT1
41	G-protein coupled receptor signaling pathway	GO:007186	9.6	PIK3CG, P2RY1, CELSR2, JAK2, INS, IL8
42	positive regulation of protein kinase B signaling cascade	GO:051897	9.4	PIK3CG, AXL, INS, F7, F3, F10
43	positive regulation of nitric oxide biosynthetic process	GO:045429	9.0	JAK2, INS, IL1B, IFNG, ICAM1, ESR1
44	response to drug	GO:042493	8.8	PDE3A, REN, BGLAP, LGALS1, P2RX7, MMP9
45	negative regulation of apoptotic process	GO:043066	8.4	PIK3CG, PDE3A, SERPINE1, VEGFA, LEP, CD44

Molecular functions related to thrombosis according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	13.6	ABCB1, PPARA, PPARG, SPARC, SPTB, SP1
2	serine-type endopeptidase activity	GO:004252	12.1	LPA, AZU1, MMP2, F9, F7, F2
3	receptor binding	GO:005102	11.5	GBA, HAO1, ADIPOQ, ADM, C3, C5
4	heparin binding	GO:008201	11.3	KNG1, AZU1, PAFAH1B1, LIPG, LPA, VEGFA
5	heme binding	GO:020037	11.1	PTGIS, PTGS2, MPO, HRG, CAT, CBS
6	eukaryotic cell surface binding	GO:043499	11.1	APOH, EPO, SELP, SERPINF2, FGA, FGB
7	protein homodimerization activity	GO:042803	10.2	SOD1, PON1, NPPC, OXA1L, SLC6A4, PGF
8	protease binding	GO:002020	10.2	IL1R1, SELL, ELANE, TNFRSF1A, TNF, F3
9	cytokine activity	GO:005125	8.8	IL6, TNFSF14, TNFRSF11B, TNF, IFNG, SPP1
10	growth factor activity	GO:008083	8.3	IL10, IL1B, IL2, IL6, F2, PPBP