MCID: THR005
MIFTS: 57

Thrombotic Thrombocytopenic Purpura malady

Blood diseases category

Summaries for Thrombotic Thrombocytopenic Purpura

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MalaCards: Thrombotic Thrombocytopenic Purpura, also known as ttp - thrombotic thrombocytopenic purpura, is related to purpura and hemolytic-uremic syndrome. An important gene associated with Thrombotic Thrombocytopenic Purpura is ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Immune response Lectin induced complement pathway. The compounds dexamethasone and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone marrow and bone, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Thrombotic Thrombocytopenic Purpura

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

thrombotic thrombocytopenic purpura 8
ttp - thrombotic thrombocytopenic purpura 8
purpura, thrombotic thrombocytopenic 60
thrombotic microangiopathy nos 8
thrombotic microangiopathies 60
thrombotic microangiopathy 8
moschcowitz's syndrome 8


External Ids:

Disease Ontology8 DOID:10772
MeSH34 D011697
NCIt39 C78797
ICD1025 M31.1

Related Diseases for Thrombotic Thrombocytopenic Purpura

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17GeneCards, 18GeneDecks
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Diseases in the Thrombotic Thrombocytopenic Purpura, Congenital family:

thrombotic thrombocytopenic purpura Thrombotic Thrombocytopenic Purpura, Acquired

Diseases related to Thrombotic Thrombocytopenic Purpura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 228)
idRelated DiseaseScoreTop Affiliating Genes
1purpura32.4THPO, ADAMTS13
2hemolytic-uremic syndrome31.6CFH, CD46, THBD, VWF, ADAMTS13, CFI
3thrombotic thrombocytopenic purpura, acquired31.3CFH, VWF, HP, CD46, THBS1, ADAMTS13
4lupus erythematosus31.3THBD
5systemic lupus erythematosus31.3ADAMTS13, CD46, PTPN22, THBD, CFH, CFI
6thrombocytopenia31.0HP, THPO, CFH, VWF, THBD, ADAMTS13
7connective tissue disease31.0PTPN22, THBD, VWF
8thrombotic thrombocytopenic purpura, congenital31.0HP, ADAMTS13, CFH
9hepatitis30.9IL2RB, HP
10hepatitis c30.9CD9, THPO, HP
11hemolytic anemia30.9HP, VWF, CFH, ADAMTS13
12disseminated intravascular coagulation30.9SERPINF2, ADAMTS13, THBD, THPO, PPIC
13myeloma30.8CD9, CFLAR
14myocardial infarction30.8CFH, SERPINF2, VWF, ADAMTS13
15hellp syndrome30.8HP, VWF, ADAMTS13
16antiphospholipid syndrome30.8ADAMTS13, CFH, THBD, VWF
17glomerulonephritis30.7CD46, CFH, CFI
18atypical hemolytic-uremic syndrome30.7CFH, CD46, THBD, CFI
19sickle cell disease30.7VWF, HP, CFI, THBS1
20adenocarcinoma30.7CD46, THBS1, CFLAR, THBD, KRT7, CD9
21acute myocardial infarction30.5ADAMTS13, VWF, THBD, SERPINF2
22vasculitis30.5VWF, CD46, THBD, CFI
23ischemia30.5CFLAR, ADAMTS13, HP, IL2RB
24prostate cancer30.5STX1A, CD9, CFLAR, THBS1, CD46
25leukemia30.5IL2RB, CD9, CFLAR, CD46, THPO, SERPINF2
26nephrotic syndrome30.3CFI, SERPINF2, HP
27ovarian cancer30.3THBS1, KRT7, CFI, HP, CD46, CD9
28peritonitis30.3CFI
29lung cancer30.3KRT7
30uremia30.3VWF
31thymoma30.3TSR1
32pneumonia30.3IL2RB, CD9
33thrombophilia30.3THBD, SERPINF2, VWF
34collagen disease30.3VWF, THBD
35membranoproliferative glomerulonephritis30.3CD46, CFH
36liver cirrhosis30.3THPO, SERPINF2, ADAMTS13, HP
37pre-eclampsia30.3SERPINF2, HP, VWF, THBD, ADAMTS13
38graves' disease30.3PTPN22
39colon cancer30.3CFI, CD9, THBS1, CFLAR
40systemic scleroderma30.3PTPN22, THBD, VWF, IL2RB, CD46
41vascular disease30.3THBD, HP, CD46, VWF
42melanoma30.3CFI, CD46, IL2RB, CFLAR, CD9, THBS1
43malaria30.1ADAMTS13, HP, IL2RB
44meningitis30.1CFI, CD46
45squamous cell carcinoma30.1CD9, KRT7, THBS1, THBD, CFLAR, CD46
46autoimmune thrombocytopenic purpura10.8
47pancreatitis10.8
48retinitis10.8
49acute pancreatitis10.7
50mixed connective tissue disease10.6

Graphical network of the top 20 diseases related to Thrombotic Thrombocytopenic Purpura:



Diseases related to thrombotic thrombocytopenic purpura

Clinical Features for Thrombotic Thrombocytopenic Purpura

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Drugs & Therapeutics for Thrombotic Thrombocytopenic Purpura

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Thrombotic Thrombocytopenic Purpura

Drug clinical trials:

Search ClinicalTrials for Thrombotic Thrombocytopenic Purpura

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Search CenterWatch for Thrombotic Thrombocytopenic Purpura

Genetic Tests for Thrombotic Thrombocytopenic Purpura

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Anatomical Context for Thrombotic Thrombocytopenic Purpura

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32MalaCards
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MalaCards organs/tissues related to Thrombotic Thrombocytopenic Purpura:

32
Endothelial, Bone marrow, Bone, Testes, Liver, Kidney, B cells, Lung, Heart, Prostate, Retina, Breast, Pancreatic islet, Brain, Cortex, Colon, Pancreas, Pituitary

Animal Models for Thrombotic Thrombocytopenic Purpura or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thrombotic Thrombocytopenic Purpura:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.9CFI, CFH, THBS1, KRT7, PTPN22, HP
2MP:00053979.5ADAMTS13, CD9, HP, IL2RB, VWF, CFLAR
3MP:00053879.4VWF, IL2RB, HP, CD9, CFLAR, CFH
4MP:00053769.3CFLAR, VWF, HP, STX1A, CFI, CFH

Publications for Thrombotic Thrombocytopenic Purpura

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50PubMed
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Articles related to Thrombotic Thrombocytopenic Purpura:

(show top 50)    (show all 718)
idTitleAuthorsYear
1
Erratum to: Bilateral serous detachment of retina: an unusual mode of revelation of thrombotic thrombocytopenic purpura of favorable outcome with plasma exchange. (24257891)
2014
2
Thrombotic thrombocytopenic purpura (TTP)-like illness associated with intravenous Opana ER abuse--Tennessee, 2012. (23302815)
2013
3
Thrombotic thrombocytopenic purpura: 2012 American Society for Apheresis (ASFA) consensus conference on classification, diagnosis, management, and future research. (24136342)
2013
4
A novel Wiskott-Aldrich syndrome protein mutation in an infant with thrombotic thrombocytopenic purpura. (23237501)
2013
5
Hereditary thrombotic thrombocytopenic purpura and the hereditary TTP registry. (23715103)
2013
6
Persistence of circulating ADAMTS13-specific immune complexes in patients with acquired thrombotic thrombocytopenic purpura. (24241492)
2013
7
A postoperative thrombotic thrombocytopenic purpura in a cardiac surgery patient: a case report. (23772412)
2013
8
Thrombotic thrombocytopenic purpura-what is new? (23420593)
2013
9
Reversible posterior leukoencephalopathy syndrome in a case of adult onset Still's disease with concurrent thrombotic thrombocytopenic purpura: response to high dose immunoglobulin infusions. (23767207)
2012
10
Targeting B cells in severe thrombotic thrombocytopenic purpura--a road to cure? (22179358)
2012
11
Thrombotic thrombocytopenic purpura due to anti-ADAMTS13 antibodies in multiple myeloma. (23073062)
2012
12
Extensive bilateral ischemic stroke after platelet transfusion in thrombotic thrombocytopenic purpura (TTP): a case report. (22574558)
2012
13
Indications for a protective function of beta2-glycoprotein I in thrombotic thrombocytopenic purpura. (22881339)
2012
14
Acquired idiopathic ADAMTS13 activity deficient thrombotic thrombocytopenic purpura in a population from Japan. (22427934)
2012
15
Congenital thrombotic thrombocytopenic purpura (cTTP) with two novel mutations. (22488907)
2012
16
Is there a link between thrombotic thrombocytopenic purpura and anti-glomerular basement membrane disease? (21430178)
2011
17
Thrombotic thrombocytopenic purpura mimicking an acute meningoencephalitis. (21485766)
2011
18
Postendoscopic retrograde cholangiopancreatography pancreatitis: a rare cause of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. (21716116)
2011
19
Thrombotic thrombocytopenic purpura. (22068077)
2011
20
Systemic infections mimicking thrombotic thrombocytopenic purpura. (21850657)
2011
21
A case of pregnancy-induced thrombotic thrombocytopenic purpura with a kidney allograft recipient. (20590698)
2010
22
The challenges of diagnosing thrombotic thrombocytopenic purpura in the critically ill. A case report. (20691639)
2010
23
Pathophysiology of thrombotic thrombocytopenic purpura. (20058209)
2010
24
Thrombotic thrombocytopenic purpura: recognition and management. (20058208)
2010
25
Priapism and penile gangrene due to thrombotic thrombocytopenic purpura. (19896177)
2010
26
Brain lesions are most often reversible in acute thrombotic thrombocytopenic purpura. (19564586)
2009
27
Hypersensitivity to plasma exchange in a patient with thrombotic thrombocytopenic purpura. (19073012)
2009
28
Cardiac involvement in acute thrombotic thrombocytopenic purpura: association with troponin T and IgG antibodies to ADAMTS 13. (19175494)
2009
29
Thrombotic thrombocytopenic purpura: the masquerader. (19373147)
2009
30
Frequency and significance of HIV infection among patients diagnosed with thrombotic thrombocytopenic purpura. (19275493)
2009
31
Long-term deficits in health-related quality of life after recovery from thrombotic thrombocytopenic purpura. (18954401)
2009
32
Molecular basis of ADAMTS13 dysfunction in thrombotic thrombocytopenic purpura. (18807073)
2009
33
The active conformation of von Willebrand factor in patients with thrombotic thrombocytopenic purpura in remission. (19548905)
2009
34
Methylene blue-photoinactivated plasma versus quarantine fresh frozen plasma in thrombotic thrombocytopenic purpura: a multicentric, prospective cohort study. (18637799)
2008
35
Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project. (17868804)
2007
36
Thrombotic thrombocytopenic purpura-like thrombocytopenia closely related to uremia: report of two cases. (17845398)
2007
37
The kidney in thrombotic thrombocytopenic purpura. (18299685)
2007
38
Purtscher-like retinopathy in a patient with adult-onset Still's disease and concurrent thrombotic thrombocytopenic purpura. (17266110)
2007
39
Recurrent idiopathic thrombotic thrombocytopenic purpura: a role for vaccination in disease relapse? (16931205)
2006
40
Thrombotic thrombocytopenic purpura. (16102032)
2005
41
von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura. (14727254)
2004
42
Acquired protein S deficiency in thrombotic thrombocytopenic purpura patients receiving solvent/detergent plasma exchange. (12877681)
2003
43
Rituximab induces remission of cerebral ischemia caused by thrombotic thrombocytopenic purpura. (12605663)
2003
44
Plasma levels of total plasminogen activator inhibitor-I (PAI-I) and tPA/PAI-1 complex in patients with disseminated intravascular coagulation and thrombotic thrombocytopenic purpura. (11441985)
2001
45
Acquired deficiency of von Willebrand factor-cleaving protease in a patient with thrombotic thrombocytopenic purpura. (9531594)
1998
46
Thrombotic thrombocytopenic purpura accompanied by transient pure red cell aplasia and thymoma. (9543602)
1998
47
Increased P-selectin plasma levels in patients with thrombotic thrombocytopenic purpura. (8900845)
1996
48
Platelet-agglutinating protein p37 from a thrombotic thrombocytopenic purpura plasma forms complexes with platelet membrane glycoprotein IV (CD36). (1384492)
1992
49
A cathepsin-like cysteine proteinase proaggregating activity in thrombotic thrombocytopenic purpura. (1751375)
1991
50
Massive bilateral retinal vascular occlusion secondary to thrombotic thrombocytopenic purpura. (2976518)
1988

Genetic Variations for Thrombotic Thrombocytopenic Purpura

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Expression for genes affiliated with Thrombotic Thrombocytopenic Purpura

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thrombotic Thrombocytopenic Purpura

Search GEO for disease gene expression data for Thrombotic Thrombocytopenic Purpura.

Pathways for genes affiliated with Thrombotic Thrombocytopenic Purpura

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53Reactome, 52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Thrombotic Thrombocytopenic Purpura

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Thrombotic Thrombocytopenic Purpura according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1113.7CD46, CFH
2endotoxin4410.7ADAMTS13, THBD
3heparin44 28 11 2413.6ADAMTS13, CFI, HP, THPO
4desmopressin44 59 28 1113.6ADAMTS13, VWF, THBD, SERPINF2
5txb24410.5VWF, THBS1, SERPINF2, THBD
6hirudin4410.5VWF, THBS1, THBD, THPO, SERPINF2
7carbohydrates4410.5THBD, CFI, HP, VWF
86-ketoprostaglandin f1alpha4410.5VWF, THBD, SERPINF2
9matrigel4410.5THBS1, KRT7
10thromboxane44 2411.5THPO, THBD, VWF, SERPINF2, CD9
11kininogen4410.5HP, VWF, CFI, THBS1, THBD, SERPINF2
12ristocetin4410.4VWF, ADAMTS13, SERPINF2
13rituximab44 49 1112.4ADAMTS13, CFLAR, VWF, HP
14agarose4410.4HP, THPO, VWF, THBS1, THBD
15cyclophosphamide44 49 1112.4THBD, CD46, IL2RB, VWF, THBS1, ADAMTS13
16pentoxifylline44 1111.4IL2RB, CD9, HP, THBD
17hyaluronic acid44 2411.4THBS1, THPO, THBD, CFH, HP, VWF
18thyroxine44 2411.4CFI, VWF, IL2RB, THBD, SERPINF2, HP
19neopterin4410.4HP, IL2RB, CD9, THBD
20serine4410.4CD46, HP, IL2RB, CFLAR, THBS1, ADAMTS13
21methionine4410.4CFI, THBD, THBS1, HP, IL2RB, VWF
22nacl4410.3THBD, CFH, CFI, HP, ADAMTS13
23sialic acid4410.3HP, CD46, THPO, KRT7, SERPINF2, CFH
24aspirin44 49 28 2413.3IL2RB, CD9, THPO, THBD, VWF, HP
25ptca4410.3THBD, PPIC, SERPINF2
26polyethylene glycol4410.3CD9, HP, THBD, THPO
27glucose4410.3THBS1, STX1A, CFI, KRT7, THBD, CFH
28creatinine4410.3HP, THPO, CFI, VWF, IL2RB, THBD
29latex4410.3THBS1, CD9, THPO, VWF
30sucrose44 11 2412.3THPO, HP, CD9, THBD, CFI
31paraffin4410.2CD9, CD46, VWF, THBS1, THBD, KRT7
32h2o24410.2CFLAR, THPO, CD9, HP, VWF, THBD
33testosterone44 59 11 2413.2CFLAR, SERPINF2, KRT7, VWF, HP, THBS1
34p0024410.2CD9, HP, THPO, CFLAR
35vegf4410.1THBD, CFLAR, THBS1, IL2RB, HP, THPO
36gold4410.1THPO, THBS1, IL2RB, CD9
37estrogen4410.1THPO
38cysteine4410.1CFH, STX1A, THBS1, HP, THBD, CFLAR
39cyclosporin a44 28 5912.1THBS1, ADAMTS13, IL2RB, PPIC, CD46, HP
40cholesterol44 28 11 2413.1HP, THBD, VWF, STX1A, CD9, IL2RB
41alanine4410.1SERPINF2, THBD, HP, CFH, THBS1, CD46
42nitric oxide44 11 2412.0CD9, STX1A, THPO, CD46, HP, VWF
43retinoic acid44 2411.0THBS1, CFLAR, CFI, CD9, IL2RB, VWF
44polysaccharide4410.0THPO, THBD, THBS1, CFH, IL2RB, HP
45fibrinogen4410.0VWF, ADAMTS13, SERPINF2, THPO, THBD, THBS1
46lipid4410.0SERPINF2, THBD, STX1A, CD9, HP, IL2RB
47rapamycin4410.0CFLAR, CD46, THBS1, IL2RB, THPO
48progesterone44 59 28 11 2413.9THBS1, CD46, HP, KRT7, THBD, IL2RB
49calcium44 49 11 2412.9VWF, STX1A, ADAMTS13, SERPINF2, THPO, THBS1
50tyrosine449.7CFLAR, PTPN22, THBS1, THBD, GPR182, VWF

GO Terms for genes affiliated with Thrombotic Thrombocytopenic Purpura

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16Gene Ontology
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Cellular components related to Thrombotic Thrombocytopenic Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:03109310.3SERPINF2, THBS1, VWF
2fibrinogen complexGO:00557710.2SERPINF2, THBS1
3cell surfaceGO:00998610.2CD46, THBS1, THBD, SERPINF2, ADAMTS13
4external side of plasma membraneGO:00989710.1CD9, IL2RB, VWF, THBS1
5extracellular spaceGO:00561510.1ADAMTS13, SERPINF2, THPO, THBS1, CFH, CFI
6platelet alpha granuleGO:03109110.0THBS1, VWF
7extracellular regionGO:0055769.9HP, VWF, CFI, CFH, THBS1, SERPINF2

Biological processes related to Thrombotic Thrombocytopenic Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of plasminogen activationGO:01075710.3SERPINF2, THBS1
2negative regulation of fibrinolysisGO:05191810.3SERPINF2, THBD, THBS1
3platelet degranulationGO:00257610.1CD9, VWF, THBS1, SERPINF2
4platelet activationGO:03016810.1ADAMTS13, CD9, VWF, THBS1, THPO, SERPINF2
5regulation of complement activationGO:0304499.9CFH, CFI, CD46
6blood coagulationGO:0075969.9CD9, VWF, THBS1, THBD, THPO, SERPINF2

Molecular functions related to Thrombotic Thrombocytopenic Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00202010.2SERPINF2, CFLAR, VWF
2integrin bindingGO:00517810.2ADAMTS13, THBS1, VWF, CD9
3glycoprotein bindingGO:00194810.2STX1A, VWF, THBS1
4protein bindingGO:0055159.0STX1A, CD9, HP, VWF, CFLAR, CFH

Products for genes affiliated with Thrombotic Thrombocytopenic Purpura

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Sources for Thrombotic Thrombocytopenic Purpura

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet