MCID: THR005
MIFTS: 55

Thrombotic Thrombocytopenic Purpura malady

Blood category

Summaries for Thrombotic Thrombocytopenic Purpura

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33MalaCards
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MalaCards: Thrombotic Thrombocytopenic Purpura, also known as ttp - thrombotic thrombocytopenic purpura, is related to thrombotic thrombocytopenic purpura, acquired and hemolytic-uremic syndrome. An important gene associated with Thrombotic Thrombocytopenic Purpura is ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Immune response Lectin induced complement pathway. The compounds dexamethasone and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and kidney, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Thrombotic Thrombocytopenic Purpura

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

thrombotic thrombocytopenic purpura 8
ttp - thrombotic thrombocytopenic purpura 8
purpura, thrombotic thrombocytopenic 61
thrombotic microangiopathy nos 8
thrombotic microangiopathies 61
thrombotic microangiopathy 8
moschcowitz's syndrome 8


External Ids:

Disease Ontology8 DOID:10772
MeSH35 D011697
NCIt40 C78797
ICD1025 M31.1

Related Diseases for Thrombotic Thrombocytopenic Purpura

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the thrombotic thrombocytopenic purpura, congenital family:

thrombotic thrombocytopenic purpura thrombotic thrombocytopenic purpura, acquired

Diseases related to Thrombotic Thrombocytopenic Purpura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 235)
idRelated DiseaseScoreTop Affiliating Genes
1thrombotic thrombocytopenic purpura, acquired31.8ADAMTS13, CFH, CD46
2hemolytic-uremic syndrome31.7CD46, VWF, CFI, CFH, THBD, ADAMTS13
3thrombotic thrombocytopenic purpura, congenital31.5ADAMTS13, CFH, HP
4systemic lupus erythematosus31.3CD46, IL2RB, VWF, CFI, CFH, THBD
5thrombocytopenia31.1CD46, HP, VWF, CFH, THBD, THPO
6hepatitis c30.9CD9, HP, THPO
7hellp syndrome30.8HP, VWF, ADAMTS13
8antiphospholipid syndrome30.8VWF, CFH, THBD, ADAMTS13
9nephritis30.7CFI
10atypical hemolytic-uremic syndrome30.7CD46, CFI, CFH, THBD
11sickle cell disease30.7HP, VWF, CFI, THBS1
12adenocarcinoma30.7CD9, CD46, CFLAR, THBS1, THBD, KRT7
13acute myocardial infarction30.6VWF, THBD, SERPINF2, ADAMTS13
14sepsis30.6CFI, SERPINF2
15vasculitis30.6THBD, CFI, VWF, CD46
16uremia30.3VWF
17blindness30.3CFH
18thymoma30.3TSR1
19afibrinogenemia30.3CFI
20thrombophilia30.3VWF, THBD, SERPINF2
21membranoproliferative glomerulonephritis30.3CD46, CFH
22graves' disease30.3PTPN22
23systemic scleroderma30.3PTPN22, THBD, VWF, IL2RB, CD46
24vascular disease30.3THBD, VWF, HP, CD46
25squamous cell carcinoma30.1CD9, CD46, CFLAR, THBS1, THBD, KRT7
26autoimmune thrombocytopenic purpura10.8
27acute pancreatitis10.7
28mixed connective tissue disease10.7
29adult-onset still's disease10.7
30micro syndrome10.6
31adult syndrome10.6
32hemoglobin d disease10.5
33central retinal vein occlusion10.5
34hepatitis a10.5
35bone marrow necrosis10.5
36hematopoietic stem cell transplantation10.5
37hemoglobin c disease10.5
38n syndrome10.5
39bone marrow cancer10.5
40sickle cell - hemoglobin d disease10.5
41sickle cell - hemoglobin c disease10.5
42catastrophic antiphospholipid syndrome10.5
43graft versus host disease10.4
44stroke, ischemic10.4
45crohn's disease10.4
46status epilepticus10.4
47wiskott-aldrich syndrome10.4
48polyarteritis nodosa10.4
49autoimmune hemolytic anemia10.4
50coronary thrombosis10.4

Graphical network of the top 20 diseases related to Thrombotic Thrombocytopenic Purpura:



Diseases related to thrombotic thrombocytopenic purpura

Clinical Features for Thrombotic Thrombocytopenic Purpura

Drugs & Therapeutics for Thrombotic Thrombocytopenic Purpura

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Thrombotic Thrombocytopenic Purpura

Drug clinical trials:

Search ClinicalTrials for Thrombotic Thrombocytopenic Purpura

Search NIH Clinical Center for Thrombotic Thrombocytopenic Purpura

Search CenterWatch for Thrombotic Thrombocytopenic Purpura

Genetic Tests for Thrombotic Thrombocytopenic Purpura

Anatomical Context for Thrombotic Thrombocytopenic Purpura

Sources:
33MalaCards
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MalaCards organs/tissues related to Thrombotic Thrombocytopenic Purpura:

33
Liver, Brain, Kidney, Lung, Bone marrow, Cortex, Retina, Heart, Small intestine, Colon, Pancreas, Breast, Prostate, T cells, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Pancreatic islet, Pituitary

Animal Models for Thrombotic Thrombocytopenic Purpura or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Thrombotic Thrombocytopenic Purpura:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.9CFI, CFH, THBS1, KRT7, PTPN22, HP
2MP:00053979.5ADAMTS13, CD9, HP, IL2RB, VWF, CFLAR
3MP:00053879.4VWF, IL2RB, HP, CD9, CFLAR, CFH
4MP:00053769.3CFLAR, VWF, HP, STX1A, CFI, CFH

Publications for Thrombotic Thrombocytopenic Purpura

Sources:
51PubMed
See all sources

Articles related to Thrombotic Thrombocytopenic Purpura:

(show top 50)    (show all 719)
idTitleAuthorsYear
1
Thrombotic thrombocytopenic purpura and other thrombotic microangiopathic hemolytic anemias: Diagnosis and classification. (24418304)
2014
2
Congenital thrombotic thrombocytopenic purpura with novel mutations in three unrelated turkish children. (24115559)
2014
3
Thrombotic thrombocytopenic purpura in children. (23422353)
2013
4
Thrombotic thrombocytopenic purpura (TTP). (23610839)
2013
5
Thrombotic thrombocytopenic purpura at presentation of juvenile systemic lupus erythematosus patients. (23588522)
2013
6
Autopsy case of sudden maternal death from thrombotic thrombocytopenic purpura. (22765161)
2013
7
Thrombotic thrombocytopenic purpura in a 15-year-old female. (23519752)
2013
8
Low ADAMTS-13 in plavix induced thrombotic thrombocytopenic purpura. (24303458)
2013
9
Novel frameshift mutations in ADAMTS13 in two families with hereditary thrombotic thrombocytopenic purpura. (23677910)
2013
10
Drug-induced thrombotic thrombocytopenic purpura successfully treated with recombinant human soluble thrombomodulin. (23676600)
2013
11
Platelet recovery rate during plasma exchange predicts early and late responses in patients with thrombotic thrombocytopenic purpura. (22905833)
2013
12
ADAMTS-13 may not predict disease or outcome in patients with Thrombotic Thrombocytopenic Purpura. (23411128)
2013
13
Complement activation and mortality during an acute episode of thrombotic thrombocytopenic purpura. (23927533)
2013
14
Inverse correlation of free and immune complex-sequestered anti-ADAMTS13 antibodies in a patient with acquired thrombotic thrombocytopenic purpura. (22044668)
2012
15
Thrombotic thrombocytopenic purpura triggered by influenza A virus subtype H1N1 infection. (22094185)
2012
16
Transfusion medicine illustrated. Massive hemolysis due to thrombotic thrombocytopenic purpura in a patient with AIDS. (22780894)
2012
17
The use of ADAMTS13 activity, platelet count, and serum creatinine to differentiate acquired thrombotic thrombocytopenic purpura from other thrombotic microangiopathies. (22296585)
2012
18
The TITAN trial--assessing the efficacy and safety of an anti-von Willebrand factor Nanobody in patients with acquired thrombotic thrombocytopenic purpura. (22475545)
2012
19
Splenectomy and/or cyclophosphamide as salvage therapies in thrombotic thrombocytopenic purpura: the French TMA Reference Center experience. (22404639)
2012
20
Blood group O and black race are independent risk factors for thrombotic thrombocytopenic purpura associated with severe ADAMTS13 deficiency. (21470236)
2011
21
Thrombotic thrombocytopenic purpura with severe hypertension in a patient with systemic sclerosis sine scleroderma and polymyositis. (22001478)
2011
22
Sepsis-induced disseminated intravascular coagulation with features of thrombotic thrombocytopenic purpura: a fatal fulminant syndrome. (20211920)
2011
23
Different clinical severity of first episodes and recurrences of thrombotic thrombocytopenic purpura. (20955397)
2010
24
Thrombotic thrombocytopenic purpura and multiorgan system failure in a child with sickle cell-hemoglobin C disease. (19525485)
2010
25
Difficulties in diagnosing congenital thrombotic thrombocytopenic purpura. (20118810)
2010
26
Successful prevention of thrombotic thrombocytopenic purpura (TTP) relapse using monthly prophylactic plasma exchanges throughout pregnancy in a patient with systemic lupus erythematosus and a prior history of refractory TTP and recurrent fetal loss. (20547472)
2010
27
Etanercept-refractory adult-onset Still's disease with thrombotic thrombocytopenic purpura successfully treated with tocilizumab. (20225049)
2010
28
ADAMTS-13 assays in thrombotic thrombocytopenic purpura. (20088924)
2010
29
Efficacy and safety of rituximab in adult patients with idiopathic relapsing or refractory thrombotic thrombocytopenic purpura: results of a Spanish multicenter study. (20934383)
2010
30
Primary antiphospholipid syndrome with thrombotic thrombocytopenic purpura: a very unusual association. (19578110)
2009
31
Cyclosporine therapy in refractory/relapsed patients with thrombotic thrombocytopenic purpura. (19306354)
2009
32
Thrombotic thrombocytopenic purpura in childhood. (19544391)
2009
33
Interventions for hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: a systematic review of randomized controlled trials. (18950913)
2009
34
The spectrum of thrombotic thrombocytopenic purpura: a clinicopathologic demonstration of tacrolimus-induced thrombotic thrombocytopenic purpura in a lung transplant patient. (18580733)
2008
35
Lessons learned from the Oklahoma thrombotic thrombocytopenic purpura-hemolytic uremic syndrome registry. (18618590)
2008
36
Myocardial infarction in thrombotic thrombocytopenic purpura: a single-center experience and literature review. (18616514)
2008
37
Thrombotic thrombocytopenic purpura associated with multiple myeloma. (18600096)
2008
38
Platelet transfusion in a patient with thrombotic thrombocytopenic purpura presenting for splenectomy--a case report. (18637612)
2008
39
ADAMTS13-binding IgG are present in patients with thrombotic thrombocytopenic purpura. (16676082)
2006
40
Thrombotic microangiopathy in malignant hypertension and hemolytic uremic syndrome (HUS)/ thrombotic thrombocytopenic purpura (TTP): can we differentiate one from the other? (15969259)
2005
41
Thrombotic thrombocytopenic purpura in children -- pathophysiologic mechanisms and their clinical significance]. (16733283)
2005
42
Development of ADAMTS13 inhibitor in a patient with hepatitis C virus-related liver cirrhosis causes thrombotic thrombocytopenic purpura. (15710227)
2005
43
Thrombotic thrombocytopenic purpura in childhood]. (15029276)
2004
44
Central retinal vein occlusion in a patient with thrombotic thrombocytopenic purpura. (11336953)
2001
45
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. (11586351)
2001
46
Subacute bacterial endocarditis with polyarthritis mimicking thrombotic thrombocytopenic purpura: a case report. (19077958)
1995
47
Familial thrombotic thrombocytopenic purpura imitating HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) in two sisters during pregnancy. (8116734)
1994
48
Increased levels of vascular endothelial cell markers in thrombotic thrombocytopenic purpura. (8266913)
1993
49
von Willebrand factor and animal models: contributions to gene therapy, thrombotic thrombocytopenic purpura, and coronary artery thrombosis. (2072761)
1991
50
Thrombotic thrombocytopenic purpura in an asplenic patient with hereditary spherocytosis: failure of plasmapheresis, antiplatelet therapy, and corticosteroids. (3189717)
1988

Genetic Variations for Thrombotic Thrombocytopenic Purpura

Expression for genes affiliated with Thrombotic Thrombocytopenic Purpura

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Thrombotic Thrombocytopenic Purpura

Search GEO for disease gene expression data for Thrombotic Thrombocytopenic Purpura.

Pathways for genes affiliated with Thrombotic Thrombocytopenic Purpura

Sources:
54Reactome, 53R&D Systems, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
See all sources

Compounds for genes affiliated with Thrombotic Thrombocytopenic Purpura

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Thrombotic Thrombocytopenic Purpura according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1dexamethasone45 50 29 1113.7CFH, CD46
2endotoxin4510.7ADAMTS13, THBD
3heparin45 29 11 2413.6HP, CFI, THPO, ADAMTS13
4desmopressin45 60 29 1113.6VWF, THBD, SERPINF2, ADAMTS13
5txb24510.5VWF, THBS1, THBD, SERPINF2
6hirudin4510.5VWF, THBS1, THBD, THPO, SERPINF2
7carbohydrates4510.5HP, VWF, CFI, THBD
86-ketoprostaglandin f1alpha4510.5SERPINF2, THBD, VWF
9matrigel4510.5KRT7, THBS1
10thromboxane45 2411.5CD9, VWF, THBD, THPO, SERPINF2
11kininogen4510.5HP, VWF, CFI, THBS1, THBD, SERPINF2
12ristocetin4510.4ADAMTS13, SERPINF2, VWF
13rituximab45 50 1112.4HP, VWF, CFLAR, ADAMTS13
14agarose4510.4HP, VWF, THBS1, THBD, THPO
15cyclophosphamide45 50 1112.4THBD, THBS1, VWF, IL2RB, CD46, ADAMTS13
16pentoxifylline45 1111.4CD9, HP, IL2RB, THBD
17hyaluronic acid45 2411.4HP, VWF, CFH, THBS1, THBD, THPO
18thyroxine45 2411.4HP, IL2RB, VWF, CFI, THBD, SERPINF2
19neopterin4510.4THBD, IL2RB, HP, CD9
20serine4510.4CD46, HP, IL2RB, CFLAR, THBS1, ADAMTS13
21methionine4510.4HP, IL2RB, VWF, CFI, THBS1, THBD
22nacl4510.3ADAMTS13, THBD, CFH, CFI, HP
23sialic acid4510.3CD46, HP, CFH, THPO, KRT7, SERPINF2
24aspirin45 50 29 2413.3CD9, HP, IL2RB, VWF, THBD, THPO
25ptca4510.3SERPINF2, THBD, PPIC
26polyethylene glycol4510.3CD9, HP, THBD, THPO
27glucose4510.3STX1A, CFLAR, CFI, CFH, THBS1, THBD
28creatinine4510.3HP, IL2RB, VWF, CFI, THBD, THPO
29latex4510.3CD9, VWF, THBS1, THPO
30sucrose45 11 2412.3CD9, HP, CFI, THBD, THPO
31paraffin4510.2CD9, CD46, VWF, THBS1, THBD, KRT7
32h2o24510.2CD9, HP, VWF, CFLAR, THBS1, THBD
33testosterone45 60 11 2413.2HP, VWF, CFLAR, CFI, THBS1, KRT7
34p0024510.2CD9, HP, CFLAR, THPO
35vegf4510.1HP, IL2RB, VWF, CFLAR, THBS1, THBD
36gold4510.1THPO, THBS1, IL2RB, CD9
37estrogen4510.1THPO
38cysteine4510.1STX1A, CD9, HP, VWF, CFLAR, CFH
39cyclosporin a45 29 6012.1IL2RB, HP, CD46, PPIC, VWF, CFLAR
40cholesterol45 29 11 2413.1STX1A, CD9, HP, IL2RB, VWF, CFI
41alanine4510.1IL2RB, HP, CD46, CD9, VWF, CFH
42nitric oxide45 11 2412.0STX1A, CD9, CD46, HP, IL2RB, VWF
43retinoic acid45 2411.0CD9, IL2RB, VWF, CFLAR, CFI, CFH
44polysaccharide4510.0IL2RB, HP, CD46, CD9, CFH, THBS1
45fibrinogen4510.0ADAMTS13, PPIC, CD9, HP, VWF, CFI
46lipid4510.0STX1A, CD9, HP, IL2RB, CFLAR, CFI
47rapamycin4510.0CD46, IL2RB, CFLAR, THBS1, THPO
48progesterone45 60 29 11 2413.9CD46, HP, IL2RB, THBS1, THBD, KRT7
49calcium45 50 11 2412.9IL2RB, HP, CD46, CD9, STX1A, VWF
50tyrosine459.7CD9, CD46, HP, IL2RB, VWF, GPR182

GO Terms for genes affiliated with Thrombotic Thrombocytopenic Purpura

Sources:
16Gene Ontology
See all sources

Cellular components related to Thrombotic Thrombocytopenic Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:03109310.3SERPINF2, THBS1, VWF
2fibrinogen complexGO:00557710.2SERPINF2, THBS1
3cell surfaceGO:00998610.2CD46, THBS1, THBD, SERPINF2, ADAMTS13
4external side of plasma membraneGO:00989710.1CD9, IL2RB, VWF, THBS1
5extracellular spaceGO:00561510.1ADAMTS13, SERPINF2, THPO, THBS1, CFH, CFI
6platelet alpha granuleGO:03109110.0THBS1, VWF
7extracellular regionGO:0055769.9HP, VWF, CFI, CFH, THBS1, SERPINF2

Biological processes related to Thrombotic Thrombocytopenic Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of plasminogen activationGO:01075710.3SERPINF2, THBS1
2negative regulation of fibrinolysisGO:05191810.3SERPINF2, THBD, THBS1
3platelet degranulationGO:00257610.1CD9, VWF, THBS1, SERPINF2
4platelet activationGO:03016810.1ADAMTS13, CD9, VWF, THBS1, THPO, SERPINF2
5regulation of complement activationGO:0304499.9CFH, CFI, CD46
6blood coagulationGO:0075969.9CD9, VWF, THBS1, THBD, THPO, SERPINF2

Molecular functions related to Thrombotic Thrombocytopenic Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00202010.2SERPINF2, CFLAR, VWF
2integrin bindingGO:00517810.2ADAMTS13, THBS1, VWF, CD9
3glycoprotein bindingGO:00194810.2STX1A, VWF, THBS1
4protein bindingGO:0055159.0STX1A, CD9, HP, VWF, CFLAR, CFH

Products for genes affiliated with Thrombotic Thrombocytopenic Purpura

  • Antibodies
  • Proteins
  • Lysates
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Sources for Thrombotic Thrombocytopenic Purpura

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet