MCID: THY022
MIFTS: 51

Thymic Carcinoma malady

Cancer diseases category

Summaries for Thymic Carcinoma

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32MalaCards
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MalaCards: Thymic Carcinoma, also known as thymoma, malignant, is related to thymoma and neuroendocrine carcinoma. An important gene associated with Thymic Carcinoma is CD5 (CD5 molecule), and among its related pathways are Hematopoietic cell lineage and Neuroscience. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include thymus, lung and thyroid, and related mouse phenotypes are integument and no phenotypic analysis.

Aliases & Classifications for Thymic Carcinoma

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8Disease Ontology, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

thymic carcinoma 8 60
thymoma, malignant 8
malignant thymoma 8


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Disease Ontology8 DOID:3284
MeSH34 D013945
SNOMED-CT56 128717008, 15949004
NCIt39 C7612

Related Diseases for Thymic Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Thymic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.2TP63, CEACAM3, CD5, NGFR, DNTT, NTRK1
2neuroendocrine carcinoma30.6TP63, KRT7, KRT18, KRT19, KIT, MUC1
3thymus cancer30.3TP63, ALPP, CEACAM3, KRT7, KRT18, KIT
4acute leukemia30.1KIT, DNTT
5mucoepidermoid carcinoma30.1TP63, KRT7, MUC1, S100A1
6adenoid cystic carcinoma30.1TP63, CEACAM3, KRT7, KRT19, KIT, MUC1
7leukemia30.1ALPP, KIT, NME1, CD5, NGFR, DNTT
8squamous cell carcinoma30.1TP63, ALPP, CEACAM3, MSLN, KRT7, KRT18
9adenoma29.9TP63, CEACAM3, KRT7, KRT18, KRT19, NME1
10hepatitis29.9ALPP
11spindle cell carcinoma29.9TP63, MUC1
12meningioma29.9MUC1, SYP, S100A1, CALB2
13large cell carcinoma29.9TP63, CEACAM3, KRT7, SYP, NKX2-1
14neuroendocrine tumor29.9CEACAM3, KRT19, NTRK1, SYP, NKX2-1
15sarcoma29.9TP63, KIT, MUC1, NTRK1, S100A1, CALB2
16neuroblastoma29.9NME1, NGFR, NTRK1, SYP
17papillary carcinoma29.9TP63, CEACAM3, KRT7, KRT18, KRT19, NME1
18adenocarcinoma29.9TP63, CEACAM3, MSLN, KRT7, KRT18, KRT19
19combined thymoma10.3
20lymphoepithelioma-like thymic carcinoma10.3
21candidiasis10.3
22cortical thymoma10.3
23chronic mucocutaneous candidiasis10.2
24myocarditis10.2
25cardiac tamponade10.2
26cushing's syndrome10.2
27lymphoepithelioma-like carcinoma10.2
28dermatomyositis10.2
29mediastinitis10.2
30myasthenia gravis10.2
31thyroiditis10.2
32intestinal obstruction10.1
33intestinal pseudo-obstruction10.1
34parathyroid carcinoma10.1
35adenoiditis10.1
36aplastic anemia10.1
37cervicitis10.1
38type c thymoma10.1
39leydig cell tumor10.0CALB2
40pituitary adenoma10.0SYP
41kidney cancer10.0KRT7
42hemangioma10.0NKX2-1
43adenomatoid tumor10.0CALB2
44gastritis10.0KRT18
45pancreatitis10.0ALPP
46colon adenocarcinoma10.0CALB2
47germ cell tumors10.0KIT
48interstitial lung disease10.0MUC1
49gingivitis10.0ALPP
50arthritis10.0ALPP

Graphical network of the top 20 diseases related to Thymic Carcinoma:



Diseases related to thymic carcinoma

Clinical Features for Thymic Carcinoma

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Drugs & Therapeutics for Thymic Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Thymic Carcinoma

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Genetic Tests for Thymic Carcinoma

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Anatomical Context for Thymic Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Thymic Carcinoma:

32
Thymus, Lung, Thyroid, Brain, Testes, Breast, Bone, Pituitary, Pancreas, Kidney, Skeletal muscle, Ovary, Lymph node, Myeloid, Monocytes, Trachea

Animal Models for Thymic Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thymic Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.2KRT19, NME1
2MP:00030129.6NKX2-1, SYP, NTRK1, MUC1, CD5, KIT
3MP:00020069.4NKX2-1, MUC1, NME1, KIT, KRT19, TP63
4MP:00028738.8TP63, CALB2, S100A1, SYP, NTRK1, DNTT

Publications for Thymic Carcinoma

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50PubMed
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Articles related to Thymic Carcinoma:

(show top 50)    (show all 348)
idTitleAuthorsYear
1
Stabilization of Disease after Targeted Therapy in a Thymic Carcinoma with KIT Mutation Detected by Clinical Next-Generation Sequencing. (24419427)
2014
2
Pure white cell aplasia in a patient with thymic carcinoma. (24137702)
2013
3
Thymic neuroendocrine carcinoma producing ectopic adrenocorticotropic hormone and Cushing's syndrome. (24088497)
2013
4
Early-stage thymic carcinoma: is adjuvant therapy required? (23585943)
2013
5
Recurrent acute-onset Cushing's syndrome 6 years after removal of a thymic neuroendocrine carcinoma: from ectopic ACTH to CRH. (23233312)
2013
6
Importance of lymph node dissection in thymic carcinoma. (23806232)
2013
7
Chemotherapy with carboplatin and paclitaxel after failure of primary chemotherapy for advanced thymic carcinoma. A report of three cases and review of the literature. (24326856)
2013
8
Outcome of surgically resected thymic carcinoma: A multicenter experience. (24370198)
2013
9
Clinical outcomes with chemotherapy for advanced thymic carcinoma. (23313005)
2013
10
Thymoma and thymic carcinoma. (22237733)
2012
11
Scleromyxedema: a cutaneous paraneoplastic syndrome associated with thymic carcinoma. (22162593)
2012
12
Expression of thymidylate synthase and orotate phosphoribosyltransferase in thymic carcinoma. (23170110)
2012
13
Large thymic carcinoma presenting with right ventricular failure: a case report. (21938989)
2011
14
Impressive response with imatinib in a heavily pretreated patient with metastatic c-KIT mutated thymic carcinoma. (21969494)
2011
15
Thymic carcinoma: is it a separate entity? From molecular to clinical evidence. (21070984)
2011
16
Cushing's syndrome in a case of thymic carcinoma. (22029011)
2011
17
Results of a surgical resection for patients with thymic carcinoma. (22108742)
2011
18
Whole-body magnetic resonance imaging for staging metastatic thymic carcinoma. (21642262)
2011
19
Thymic neuroendocrine carcinoma presenting as cushing's syndrome: treatment with octreotide combined with surgery and radiotherapy. (21346385)
2011
20
Ectopic thymic carcinoma in the neck. (20667381)
2010
21
Efficacy of chemotherapy with carboplatin and paclitaxel for unresectable thymic carcinoma. (19409644)
2010
22
Giant-cell anaplastic carcinoma with osteoclastic giant cells of the chest cavity: a distinctive form of thymic carcinoma? (20667924)
2010
23
Thymic squamous cell carcinoma producing granulocyte colony-stimulating factor associated with a high serum level of interleukin 6. (19967491)
2009
24
Epstein-Barr virus (EBV) associated lymphoepithelioma-like thymic carcinoma associated with paraneoplastic syndrome of polymyositis: a rare tumor with rare association. (19893401)
2009
25
Thymic carcinoma with combined resection of the hemisternum. (18607687)
2008
26
Erlotinib in advanced well-differentiated thymic carcinoma with overexpression of EGFR: a case report. (19267104)
2008
27
Thymic carcinoma involving sternum: a case report. (18364127)
2008
28
Successful resection of dermatomyositis associated with thymic carcinoma: report of a case. (18306999)
2008
29
A case of mixed connective tissue disease complicated with thymic carcinoma and Hashimoto's thyroiditis. (17278025)
2007
30
Good syndrome with thymic adenosquamous carcinoma--report of a case. (17392673)
2007
31
Carcinoma showing thymus-like differentiation of the thyroid (CASTLE): a comparative study: evidence of thymic differentiation and solid cell nest origin. (16861971)
2006
32
Thymic carcinoma originating from the mid-posterior mediastinum. (16268928)
2005
33
Thymic carcinoma: update of current diagnostic criteria and histologic types. (16711401)
2005
34
Thymic carcinoma: state of the art review. (15183468)
2004
35
Expression of calretinin and other mesothelioma-related markers in thymic carcinoma and thymoma. (14652817)
2003
36
Thymic carcinoma with rhabdoid features. (12715336)
2003
37
Aggressive multimodality treatment of invasive thymic carcinoma. (12579125)
2003
38
Weekly chemotherapy with cisplatin, vincristine, doxorubicin, and etoposide is an effective treatment for advanced thymic carcinoma. (12942558)
2003
39
Primary thymic carcinoma. (11996244)
2002
40
Clinical and immunohistochemical study of eight cases with thymic carcinoma. (12049674)
2002
41
Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases, one with cytogenetic analysis. (11903597)
2002
42
Transesophageal echocardiographic findings of an intracavitary cardiac metastasis from a neuroendocrine thymic carcinoma. (11182779)
2001
43
Epstein-Barr virus--positive undifferentiated thymic carcinoma in a 12-year-old white girl. (10779032)
2000
44
p16INK4, pRB, p53 and cyclin D1 expression and hypermethylation of CDKN2 gene in thymoma and thymic carcinoma. (9398039)
1997
45
Treatment of pediatric malignant thymoma: long-term remission in a 14-year-old boy with EBV-associated thymic carcinoma by aggressive, combined modality treatment. (8614381)
1996
46
Thymic carcinoma involving the thyroid gland: report of two cases. (7750943)
1995
47
Occult thymic carcinoma presenting as malignant cardiac tamponade. (7647408)
1995
48
Thymic carcinoma. A distinct clinical entity responsive to chemotherapy. (8435796)
1993
49
Primary thymic carcinoma and its association with dermatomyositis and pure red cell aplasia. (1512098)
1992
50
Thymic carcinoma arising from long standing thymoma and presenting with pituitary metastases. (1773413)
1991

Genetic Variations for Thymic Carcinoma

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Expression for genes affiliated with Thymic Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thymic Carcinoma

Search GEO for disease gene expression data for Thymic Carcinoma.

Pathways for genes affiliated with Thymic Carcinoma

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29KEGG, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Thymic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1KIT, CD5, DNTT
210.0NKX2-1, SYP, NTRK1, NGFR
310.0KRT7, KRT18, KRT19

Compounds for genes affiliated with Thymic Carcinoma

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44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Thymic Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8CALB2
2butyrate4410.6DNTT, CALB2
3glutamate4410.5NGFR, NTRK1
4reticulin4410.5SYP, MUC1, KRT7
5cyanine4410.4CEACAM3, CALB2
6glycogen44 2411.4SYP, KIT, KRT18, KRT7
7dexamethasone44 49 28 1113.3ALPP, NKX2-1, NME1, KRT18
8dutp4410.3KRT18, SYP, DNTT, NTRK1
9gold4410.3CEACAM3, KRT18, KIT, MUC1, SYP
10p0034410.2NTRK1, KRT19, TP63, KIT
11serine4410.2NKX2-1, NME1, SYP, KRT19, ALPP
12p0024410.2NME1, KIT, KRT18, KRT19
13smcc4410.2KRT19, SYP
145fluorouracil4410.2NME1, KRT18, KIT, CEACAM3, MUC1
15fitc4410.2KRT19, KRT18, DNTT
16ribonucleic acid4410.1KIT, NKX2-1, NME1, KRT19, MUC1
17ethanol44 49 11 2413.1NGFR, MUC1, KRT18, SYP, CALB2
18methotrexate44 49 1112.1CEACAM3, KIT, DNTT, MUC1, KRT7
19choline44 11 2412.1ALPP, NGFR, DNTT, NTRK1, SYP, CALB2
20acetylcholine44 49 28 11 2414.1CALB2, S100A1, SYP, NGFR, NTRK1
21dmso4410.0DNTT, MUC1, NME1, ALPP, TP63, KRT18
22retinoid4410.0NTRK1, NGFR, ALPP, KRT7, KRT18, KRT19
23formaldehyde44 2411.0KRT19, NKX2-1, SYP, KRT18, KRT7, MUC1
24bromodeoxyuridine4410.0DNTT, TP63, KRT18, KRT19
25creatinine4410.0KRT18, NME1, SYP, NTRK1, KRT19, CEACAM3
26indium449.9CEACAM3, MUC1
27mucicarmine449.9CALB2, S100A1, SYP, MUC1, KRT7, CEACAM3
28steroid449.9KRT18, KRT19, NME1, NGFR, SYP, NKX2-1
29hyaluronic acid44 2410.9MSLN, KRT19, CALB2, MUC1
30matrigel449.9KRT19, NME1, KRT18, TP63, MUC1, KRT7
31cisplatin44 49 59 1112.9NME1, TP63, ALPP, KRT19, MUC1, DNTT
32zinc44 2410.9NGFR, NKX2-1, KRT18, S100A1, CALB2, DNTT
33cysteine449.8SYP, NTRK1, NGFR, NME1, S100A1, KIT
34forskolin44 49 1111.8KRT18, SYP, MUC1, NGFR, NKX2-1
35oligonucleotide449.8NTRK1, DNTT, NGFR, NME1, KIT, KRT18
36glucose449.8NGFR, MUC1, KRT19, KRT18, KRT7, CEACAM3
37lactate449.8CEACAM3, NTRK1, DNTT, NME1, KIT, KRT19
38aspartate449.8NTRK1, CEACAM3, ALPP, KRT19, KIT, NME1
39cholesterol44 28 11 2412.8CEACAM3, DNTT, NGFR, SYP, ALPP, MUC1
40testosterone44 59 11 2412.6TP63, CALB2, SYP, KRT7, NTRK1, MUC1
41nitric oxide44 11 2411.5CALB2, SYP, NTRK1, DNTT, NGFR, MUC1
42thymidine44 2410.4DNTT, CEACAM3, KRT18, KRT19, KIT, NME1
43b 723449.4TP63, MUC1, SYP, NKX2-1, S100A1, CALB2
44hematoxylin449.4KIT, KRT18, KRT7, CEACAM3, TP63, KRT19
45calcium44 49 11 2412.3NGFR, MUC1, NME1, NTRK1, SYP, S100A1
46vegf449.2NTRK1, NGFR, MUC1, KIT, KRT18, SYP
47progesterone44 59 28 11 2413.2NTRK1, SYP, NKX2-1, S100A1, CALB2, NGFR
48retinoic acid44 2410.1MUC1, NGFR, DNTT, NTRK1, SYP, NKX2-1
49tyrosine449.1TP63, NTRK1, NGFR, MUC1, CD5, NME1
50paraffin448.7S100A1, NKX2-1, SYP, NTRK1, DNTT, NGFR

GO Terms for genes affiliated with Thymic Carcinoma

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16Gene Ontology
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Cellular components related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.0KRT7, KRT18, KRT19
2cell surfaceGO:0099869.5ALPP, MSLN, MUC1, NGFR, NTRK1

Biological processes related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2TP63, MUC1

Molecular functions related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nerve growth factor bindingGO:04840610.3NGFR, NTRK1
2protein bindingGO:0055158.4TP63, S100A1, NKX2-1, NTRK1, NGFR, MUC1

Products for genes affiliated with Thymic Carcinoma

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Sources for Thymic Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet