MCID: THY022
MIFTS: 50

Thymic Carcinoma malady

Cancer diseases, Rare diseases categories

Summaries for Thymic Carcinoma

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Disease Ontology:9 A thymus cancer that derives from epithelial cells. the tumor cells in a thymic carcinoma look very different from the normal cells of the thymus, grow more quickly, and have usually spread to other parts of the body when the cancer is found.

MalaCards based summary: Thymic Carcinoma, also known as malignant thymoma, is related to thymoma and mesothelioma, and has symptoms including neoplasm of the thymus, mediastinal lymphadenopathy and respiratory insufficiency. An important gene associated with Thymic Carcinoma is CD5 (CD5 molecule), and among its related pathways are Hematopoietic cell lineage and Neuroscience. The compounds s 100 and reticulin have been mentioned in the context of this disorder. Affiliated tissues include thymus, lung and brain, and related mouse phenotypes are no phenotypic analysis and digestive/alimentary.

Wikipedia:63 Thymic carcinoma is a rare type of thymus gland cancer. It usually spreads, has a high risk of... more...

Aliases & Classifications for Thymic Carcinoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Thymic Carcinoma, Aliases & Descriptions:

Name: Thymic Carcinoma 9 11 43 47 60
Malignant Thymoma 9 47
 
Thymoma, Malignant 9
Thymoma, Type C 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 47 
Rare tumors


Characteristics (Orphanet epidemiological data):

47
thymic carcinoma:
Inheritance: Not applicable; Age of onset: Adult; Age of death: any age


External Ids:

Disease Ontology9 DOID:3284
NCIt38 C7612
MeSH33 D013945
SNOMED-CT55 15949004, 128717008
Orphanet47 99868
ICD10 via Orphanet26 C37
UMLS via Orphanet61 C0205969, C1322286

Related Diseases for Thymic Carcinoma

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Diseases related to Thymic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.3NGFR, NKX2-1, CD5
2mesothelioma30.2NKX2-1, MUC1
3lung cancer29.9KRT18, NKX2-1, SYP
4adenoma29.8KRT18, NKX2-1, SYP, MUC1
5papillary carcinoma29.8KRT18, NKX2-1, SYP, MUC1
6adenocarcinoma29.4NGFR, MUC1, SYP, NKX2-1, KRT18
7glomus tumor10.5SYP
8pulmonary blastoma10.5NKX2-1
9perineurioma10.4MUC1
10lymphoepithelioma-like thymic carcinoma10.4
11hemangioma10.4NKX2-1
12thymic epithelial tumor10.3
13merkel cell carcinoma10.3SYP, NKX2-1
14chronic mucocutaneous candidiasis10.3
15candidiasis10.3
16myocarditis10.3
17myasthenia gravis10.3
18cardiac tamponade10.3
19cushing's syndrome10.3
20dermatomyositis10.3
21mediastinitis10.3
22thyroiditis10.3
23polymyositis10.3
24choroid plexus papilloma10.2MUC1, SYP
25sertoli cell tumor10.2SYP, MUC1
26rhabdoid tumor10.2MUC1, SYP
27large cell carcinoma10.2NKX2-1, SYP
28hemangioblastoma10.2SYP, MUC1
29tubular adenocarcinoma10.2SYP, MUC1
30papillary adenocarcinoma10.2NKX2-1, MUC1
31sex cord-gonadal stromal tumor10.2MUC1, NKX2-1
32adenosquamous carcinoma10.2NKX2-1, MUC1
33abrikosov's tumor10.2NKX2-1, MUC1
34malignant pleural mesothelioma10.2MUC1, NKX2-1
35intestinal pseudo-obstruction10.2
36giant cell myocarditis10.2
37limbic encephalitis10.2
38chordoma10.2KRT18, MUC1
39angiosarcoma10.2MUC1, KRT18
40aplastic anemia10.2
41hepatitis10.2
42leukemia10.2
43cortical thymoma10.2
44adenoiditis10.2
45cervicitis10.2
46paraneoplastic syndromes10.2
47pleomorphic adenoma10.2KRT18, MUC1
48dermatofibrosarcoma protuberans10.1KIT, MUC1
49neuroendocrine tumor10.1SYP, NKX2-1
50malignant mixed mullerian tumor10.1KIT, MUC1

Graphical network of the top 20 diseases related to Thymic Carcinoma:



Diseases related to thymic carcinoma

Symptoms for Thymic Carcinoma

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Symptoms:

 47 (show all 13)
  • mediastinal/hilar adenopathies
  • thymus/thymic neoplasm/tumor/carcinoma/cancer/thymoma
  • palpebral edema/periorbital edema
  • cutaneous edema
  • diaphragmatic palsy
  • thoracic/chest pain
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • hyperhidrosis/increased sweating
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • myasthenia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • asthenia/fatigue/weakness

HPO human phenotypes related to Thymic Carcinoma:

(show all 10)
id Description Frequency HPO Source Accession
1 neoplasm of the thymus hallmark (90%) HP:0100521
2 mediastinal lymphadenopathy hallmark (90%) HP:0100721
3 respiratory insufficiency typical (50%) HP:0002093
4 diaphragmatic paralysis typical (50%) HP:0006597
5 periorbital edema typical (50%) HP:0100539
6 chest pain typical (50%) HP:0100749
7 hyperhidrosis occasional (7.5%) HP:0000975
8 weight loss occasional (7.5%) HP:0001824
9 abnormality of the pleura occasional (7.5%) HP:0002103
10 fatigable weakness occasional (7.5%) HP:0003473

Drugs & Therapeutics for Thymic Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Thymic Carcinoma

Search NIH Clinical Center for Thymic Carcinoma

Genetic Tests for Thymic Carcinoma

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Anatomical Context for Thymic Carcinoma

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MalaCards organs/tissues related to Thymic Carcinoma:

31
Thymus, Lung, Brain, Thyroid, Breast, Pituitary, Bone, Lymph node, Heart, Kidney, Pancreas, Testes, Myeloid, Monocytes, Trachea

Animal Models for Thymic Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Thymic Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1CD5, KIT, NKX2-1, SYP, MUC1
2MP:00053818.1KIT, NKX2-1, MUC1, NGFR
3MP:00053707.7NGFR, MUC1, KIT, KRT18
4MP:00028737.6NGFR, MUC1, SYP, KIT, CD5

Publications for Thymic Carcinoma

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Articles related to Thymic Carcinoma:

(show top 50)    (show all 348)
idTitleAuthorsYear
1
Immunohistochemical status of PD-L1 in thymoma and thymic carcinoma. (25799277)
2015
2
Rarest of a rare disease: challenges in advancing our knowledge of thymic carcinoma. (25524680)
2015
3
Long-term outcomes of surgery for thymic carcinoma: experience of 25 cases at a single institution. (25629460)
2015
4
Long-term follow-up and prognostic factors for advanced thymic carcinoma. (25526488)
2014
5
Massively parallel sequencing identifies recurrent mutations in TP53 in thymic carcinoma associated with poor prognosis. (25299233)
2014
6
Multimodality treatment for advanced thymic carcinoma: outcomes of induction therapy followed by surgical resection in 16 cases at a single institution. (25311849)
2014
7
Pure white cell aplasia in a patient with thymic carcinoma. (24137702)
2013
8
Successful chemotherapy with Carboplatin and s-1 for thymic carcinoma: a case report. (24348388)
2013
9
Early-stage thymic carcinoma: is adjuvant therapy required? (23585943)
2013
10
Long lasting efficacy of sorafenib in a heavily pretreated patient with thymic carcinoma. (23090205)
2012
11
Thymoma and thymic carcinoma. (22237733)
2012
12
Immunohistochemical analysis of thymic carcinoma focusing on the possibility of molecular targeted and hormonal therapies. (23054618)
2012
13
Management and outcomes of relapse after treatment for thymoma and thymic carcinoma. (22115206)
2011
14
Large thymic carcinoma presenting with right ventricular failure: a case report. (21938989)
2011
15
Promising efficacy of sorafenib in a relapsed thymic carcinoma with C-KIT exon 11 deletion mutation. (20970876)
2011
16
Thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic study of 7 cases. (21677542)
2011
17
Metastatic skull base tumor from thymic carcinoma mimicking Tolosa-Hunt syndrome. (20587979)
2010
18
Imatinib mesylate in patients with WHO B3 thymomas and thymic carcinomas. (20197733)
2009
19
Cerebellar ataxia associated with neuroendocrine thymic carcinoma and GAD antibodies. (19448100)
2009
20
Endobronchial ultrasound appearance of pulmonary artery thrombus in a patient with thymic carcinoma. (17805065)
2007
21
A case of mixed connective tissue disease complicated with thymic carcinoma and Hashimoto's thyroiditis. (17278025)
2007
22
Thymic carcinoma. (17225487)
2007
23
COX-2 upregulation in thymomas and thymic carcinomas. (16823844)
2006
24
Cerebral involvement of metastatic thymic carcinoma. (16132513)
2005
25
Aberrant methylation: common in thymic carcinomas, rare in thymomas. (16273266)
2005
26
Cardiac tamponade as manifestation of advanced thymic carcinoma. (15761459)
2005
27
Ga-67 uptake in thymic carcinoma: utility of Ga-67 scintigraphy in patient management. (14734918)
2004
28
Multimodality therapy for thymic carcinoma (TCA): results of a 30-year single-institution experience. (14758136)
2004
29
Thymic carcinoma: state of the art review. (15183468)
2004
30
Concurrent chemoradiotherapy for unresectable thymic carcinoma. (15508874)
2004
31
Thymic carcinoma: a clinicopathological and immunohistological study of 19 cases. (15049903)
2004
32
Thymic carcinoma presenting as cranial metastasis with intradural and extracranial extension: case report. (14683559)
2004
33
Efficacy of docetaxel as a second-line chemotherapy for thymic carcinoma. (15608443)
2004
34
Acquired myasthenia gravis associated with a non-invasive thymic carcinoma in a dog. (15086092)
2003
35
Postoperative radiotherapy in thymic carcinoma: treatment results and prognostic factors. (11849804)
2002
36
Metastatic thymic carcinoma in a digit: a case report. (11119681)
2000
37
Platinum-based chemotherapy with or without thoracic radiation therapy in patients with unresectable thymic carcinoma. (11095135)
2000
38
Thymic carcinoma--analysis of nineteen clinicopathological studies. (11028718)
2000
39
Thymoma and thymic carcinoma. (10366159)
1999
40
Radiotherapy for invasive thymoma and thymic carcinoma. Clinicopathological review. (10392168)
1999
41
Parathyroid-hormone-related-protein-producing thymic carcinoma presenting as a giant extrathoracic mass. (9523373)
1998
42
Late onset immunodeficiency in a patient with recurrent thymic carcinoma and myasthenia gravis. (9619646)
1998
43
Effective treatment of thymic carcinoma with operation and combination chemotherapy against acute monocyte leukemia: case report and review of the literature. (9793029)
1998
44
Assessment of residual tumor viability in thymic carcinoma by sequential thallium-201 SPECT: comparison with CT and biopsy findings. (7931668)
1994
45
Thymic carcinoma associated with pinealoma and terminating with peroxidase-negative acute myeloid leukemia. (1392188)
1992
46
Relapsing thymic carcinoma during pregnancy. (1326220)
1992
47
Primary thymic carcinoma and its association with dermatomyositis and pure red cell aplasia. (1512098)
1992
48
Establishment and characterization of a thymic carcinoma cell line (Ty-82) carrying t(15;19)(q15;p13) chromosome abnormality. (1730520)
1992
49
Thymic carcinoma. A clinicopathologic study of 13 cases. (1689123)
1990
50
Successful treatment of metastatic thymic carcinoma with cisplatin, vinblastine, bleomycin, and etoposide chemotherapy. (1699650)
1990

Variations for Thymic Carcinoma

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Cosmic variations for Thymic Carcinoma:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1133763KITthymus,NS,thymic carcinoma,undifferentiated carcinoma3

Expression for genes affiliated with Thymic Carcinoma

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Search GEO for disease gene expression data for Thymic Carcinoma.

Pathways for genes affiliated with Thymic Carcinoma

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Pathways related to Thymic Carcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CD5, KIT
28.8NKX2-1, SYP, NGFR
3
Show member pathways
8.0KRT18, KIT, MUC1, NGFR

Compounds for genes affiliated with Thymic Carcinoma

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Compounds related to Thymic Carcinoma according to GeneCards Suite gene sharing:

(show all 50)
idCompoundScoreTop Affiliating Genes
1s 100439.9MUC1, SYP
2reticulin439.9SYP, MUC1
3dutp439.8KRT18, SYP
4lithium43 49 24 1212.7SYP, MUC1
5methylcellulose439.6KRT18, KIT
6trastuzumab43 49 1211.5KIT, MUC1
7mucicarmine439.5NKX2-1, SYP, MUC1
8b 723439.5NKX2-1, SYP, MUC1
9chloroquine43 2 49 28 1213.5SYP, KIT
10ganglioside439.4NGFR, SYP
11dbc-amp439.4SYP, NGFR
12cytarabine43 49 1211.3KIT, MUC1
13creatinine439.3KRT18, SYP, MUC1
14ribonucleic acid439.2MUC1, NKX2-1, KIT
155fluorouracil439.2MUC1, KIT, KRT18
16catecholamine439.1NGFR, SYP
17actinomycin d439.1MUC1, KIT, KRT18
18p002439.0KRT18, KIT
19dopamine43 28 24 1212.0NGFR, SYP, KRT18
20agar439.0KRT18, MUC1, NGFR
21matrigel439.0NGFR, MUC1, KRT18
22phosphotyrosine439.0NGFR, SYP, KIT
23histamine43 28 2410.9KIT, SYP, NGFR
24leucine438.8NGFR, SYP, KIT
25gold438.8MUC1, SYP, KIT, KRT18
26glycogen43 249.8MUC1, SYP, KIT, KRT18
27testosterone43 59 24 1211.8KRT18, KIT, SYP, MUC1
28cholesterol43 28 24 1211.7SYP, MUC1, NGFR
29cyclic amp43 249.7NKX2-1, SYP, MUC1, NGFR
30ethanol43 49 24 1211.6KRT18, SYP, MUC1, NGFR
31lipid438.5NGFR, MUC1, SYP, KRT18
32oligonucleotide438.4NGFR, NKX2-1, KIT, KRT18
33cysteine438.4KIT, SYP, MUC1, NGFR
34formaldehyde43 249.4MUC1, SYP, NKX2-1, KIT, KRT18
35thymidine43 249.4NGFR, MUC1, KIT, KRT18
36glucose438.3NGFR, MUC1, KIT, KRT18
37forskolin43 49 1210.2NGFR, MUC1, SYP, NKX2-1, KRT18
38dexamethasone43 49 28 1211.2NGFR, MUC1, SYP, NKX2-1, KRT18
39steroid438.1NGFR, SYP, NKX2-1, KIT, KRT18
40calcium43 49 24 1211.1NGFR, MUC1, SYP, KIT, CD5
41vegf438.0KRT18, KIT, SYP, MUC1, NGFR
42nitric oxide43 24 1210.0NGFR, MUC1, SYP, KIT, KRT18
43threonine437.9NGFR, MUC1, NKX2-1, KIT, KRT18
44hematoxylin437.6KRT18, KIT, NKX2-1, SYP, MUC1, NGFR
45progesterone43 28 59 24 1211.6NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
46estrogen437.6NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
47retinoic acid43 248.6NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
48serine437.5NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
49paraffin437.2NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
50tyrosine437.2NGFR, MUC1, SYP, NKX2-1, KIT, KRT18

GO Terms for genes affiliated with Thymic Carcinoma

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Biological processes related to Thymic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apoptotic signaling pathwayGO:00971909.3CD5, NGFR

Molecular functions related to Thymic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00048889.3CD5, NGFR
2protein bindingGO:00055156.9CD5, KRT18, KIT, NKX2-1, MUC1, NGFR

Products for genes affiliated with Thymic Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Thymic Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet