Thymic Carcinoma malady

Wikipedia: Thymic carcinoma is a rare type of thymus gland cancer. It usually spreads, has a high risk of...⁴⁴ more...

MalaCards: Thymic Carcinoma, also known as thymoma, malignant (morphologic abnormality), is related to myasthenia gravis and primary hyperparathyroidism. An important gene associated with Thymic Carcinoma is CD5 (CD5 molecule), and among its related pathways are Rac1 Pathway and Actin-Based Motility by Rho Family GTPases. The compounds dmso and toluidine have been mentioned in the context of this disorder. Affiliated tissues include thymus, lung and b cells, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Aliases & Descriptions:

thymic carcinoma 6 8 32 43 thymoma, malignant (morphologic abnormality) 6

malignant thymoma 6 thymoma 43

Diseases related to thymic carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 594)

id	Related Disease	Score	Top Affiliating Genes
1	myasthenia gravis	32.1	BCL2, IL1A, CALCA, PTPRC, TG
2	primary hyperparathyroidism	28.8	ALPP, CALCA, PTHLH
3	spiradenoma	27.7	S100A1, KRT7, DNTT
4	parathyroid adenoma	27.4	BCL2, ALPP, CALCA, PTHLH, TG, SYP
5	thymic epithelial tumor	26.8	KIT, BCL2, MUC1, CD5, CALCA, NTRK1
6	leukemia/lymphoma	26.5	BCL2, MUC1, CALCA, PTHLH, PTPRC, WT1
7	hyperparathyroidism	26.4	ALPP, CALCA, PTHLH, NTRK1, WT1, EGFR
8	autoimmune thyroiditis	25.1	BCL2, IL1A, CCL5, CALCA, TG
9	thymoma	23.9	KIT, VIM, BCL2, MUC1, CEACAM3, MSLN
10	mediastinitis	23.7	KIT, VIM, VEGFC, S100A1, CEACAM3, ENO2
11	anemia	23.4	KIT, BCL2, CEACAM5, CD5, IL1A, CCL5
12	neuropathy	23.1	VIM, IL1A, ENO2, CALCA, PTGS2, NTRK1
13	carcinoma	23.0	KIT, VIM, VEGFC, BCL2, MUC1, S100A1
14	lymphoblastic leukemia	22.9	KIT, VEGFC, BCL2, CEACAM3, CD70, CD5
15	lung carcinoma	22.8	VEGFC, BCL2, S100A1, CEACAM5, MSLN, ENO2
16	diabetes mellitus	21.4	BCL2, IL1A, ENO2, CCL5, ALPP, CALCA
17	leukemia	20.0	KIT, VIM, VEGFC, BCL2, MUC1, CEACAM3
18	adenoma	18.6	KIT, VIM, VEGFC, BCL2, MUC1, S100A1
19	thyroiditis	17.1	KIT, VIM, VEGFC, BCL2, MUC1, S100A1
20	neuronitis	16.8	KIT, VIM, BCL2, MUC1, S100A1, CEACAM5
21	sarcoma	16.4	KIT, VIM, VEGFC, BCL2, MUC1, S100A1
22	pancreatitis	16.0	KIT, VIM, VEGFC, BCL2, MUC1, S100A1
23	thymus cancer	13.8	KRT7, NKX2-1
24	bronchogenic cyst	13.7	CEACAM3, NKX2-1
25	horseshoe kidney	13.7	CALB2, KRT7, SYP
26	mucinous cystadenocarcinoma	13.7	MUC1, CEACAM3, KRT7
27	cutaneous paget's disease	13.7	MUC1, CEACAM3, KRT7
28	bile duct adenoma	13.6	KRT7, KRT19
29	hereditary sensory and autonomic neuropathy type v	13.6	NTRK1, NGFR
30	nephrogenic adenoma	13.6	MUC1, TP63, KRT7
31	cribriform carcinoma	13.6	KIT, TP63
32	anal canal adenocarcinoma	13.6	KRT7, KRT19
33	endodermal sinus tumor	13.6	CEACAM5, ALPP, KRT7
34	ovarian small cell carcinoma	13.6	CALB2, PTHLH, NKX2-1
35	bowen syndrome	13.6	CEACAM3, KRT7, KRT19
36	dysgerminoma of ovary	13.5	KIT, ALPP, PTHLH
37	ameloblastic carcinoma	13.5	MUC1, TP63
38	esthesioneuroblastoma	13.5	ENO2, NTRK1, SYP
39	adenoameloblastoma	13.5	CALB2, KRT7, KRT18, KRT19
40	clear cell ependymoma	13.5	VIM, MUC1
41	prostate stromal sarcoma	13.5	VIM, MUC1
42	hirschsprung's disease	13.5	NTRK1, NGFR, SYP
43	cavernous hemangioma of face	13.5	TP63, KRT18, KRT19
44	pulmonary sclerosing hemangioma	13.5	MUC1, ENO2, SYP, NKX2-1
45	myeloid sarcoma	13.5	KIT, PTPRC, DNTT
46	heart cancer	13.5	VIM, CALB2
47	ganglioneuroblastoma	13.4	ENO2, NTRK1, SYP
48	ganglioglioma	13.4	ENO2, CALB2, NTRK1, SYP
49	adenoid squamous cell carcinoma	13.4	VIM, MUC1
50	endometrial mucinous adenocarcinoma	13.4	VIM, MUC1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to thymic carcinoma:

²²

MGI Mouse Phenotypes related to thymic carcinoma:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.9	NKX2-1, WT1, TP63
2	respiratory system phenotype	MP:0005388	9.8	PTPRC, TP63, CALCA
3	liver/biliary system phenotype	MP:0005370	9.1	EGFR, NGFR, PTPRC, KIT
4	reproductive system phenotype	MP:0005389	8.7	NKX2-1, NME1, KRT19, WT1, PTGS2, TP63
5	normal phenotype	MP:0002873	8.6	MSLN, SYP, DNTT, THBD, WT1, NTRK1
6	embryogenesis phenotype	MP:0005380	8.5	NME1, EGFR, KRT19, KRT18, TP63, ALPP
7	hematopoietic system phenotype	MP:0005397	8.4	NME1, TG, NTRK1, PTPRC, PTHLH, CD5
8	no phenotypic analysis	MP:0003012	8.3	NKX2-1, SYP, EGFR, KRT19, NTRK1, PTGS2
9	mortality/aging	MP:0010768	8.2	NKX2-1, NME1, SLC7A5, THBD, EGFR, KRT19
10	renal/urinary system phenotype	MP:0005367	8.0	EGFR, WT1, NGFR, PTPRC, PTHLH, TP63
11	immune system phenotype	MP:0005387	8.0	NTRK1, WT1, EGFR, DNTT, PTPRC, PTHLH
12	digestive/alimentary phenotype	MP:0005381	7.9	NGFR, KRT19, EGFR, NKX2-1, PTPRC, PTHLH
13	muscle phenotype	MP:0005369	7.1	WT1, NGFR, NTRK1, PTGS2, TP63, S100A1
14	tumorigenesis	MP:0002006	6.9	NKX2-1, NME1, EGFR, KRT19, PTPRC, PTGS2
15	vision/eye phenotype	MP:0005391	6.8	EGFR, NGFR, NTRK1, PTHLH, PTGS2, TP63
16	integument phenotype	MP:0010771	6.5	NGFR, KRT19, EGFR, THBD, NME1, NTRK1
17	growth/size phenotype	MP:0005378	5.6	KRT18, KRT19, EGFR, THBD, TG, NME1
18	cellular phenotype	MP:0005384	5.4	NGFR, WT1, KRT19, EGFR, THBD, DNTT
19	cardiovascular system phenotype	MP:0005385	5.3	NKX2-1, THBD, EGFR, KRT19, WT1, NGFR
20	nervous system phenotype	MP:0003631	5.3	NGFR, KRT19, EGFR, THBD, TG, SYP
21	homeostasis/metabolism phenotype	MP:0005376	4.7	PTPRC, NGFR, WT1, EGFR, THBD, TG

Articles related to thymic carcinoma:

(show all 29)

id	Title	Authors	Year	Affiliating Genes
1	MUC1 expression in thymic epithelial tumors: MUC1 may be useful marker as differential diagnosis between type B3 thymoma and thymic carcinoma. (21253760)	Kaira K.... Yamamoto N.	2011	MUC1
2	Long lasting response to the multikinase inhibitor ba y 43-9006 (Sorafenib) in a heavily pretreated metastatic thymic carcinoma. (19461405)	Bisagni G.... Boni C.	2009	KIT
3	L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas. (19347882)	Kaira K.... Mori M.	2009	SLC7A5
4	Imatinib mesylate in patients with WHO B3 thymomas an d thymic carcinomas. (20197733)	Giaccone G.... Hogendoorn P.C.	2009	KIT
5	Thymoma and thymic carcinoma arising in a thymolipoma: report of a unique case. (18480395)	Haddad H.... Sughayer M.	2009	KRT19
6	Comprehensive genomic analysis reveals clinically rel evant molecular distinctions between thymic carcinomas and thymomas. (19861435)	Girard N.... Pao W.	2009	KIT
7	Mutational status of EGFR and KIT in thymoma and thymic carcinoma. (18448188)	Yoh K.... Saijo N.	2008	EGFR, KIT
8	Erlotinib in advanced well-differentiated thymic carcinoma with overexpression of EGFR: a case report. (19267104)	Pedersini R.... Graiff C.	2008	EGFR
9	Multiple inflammatory cytokine-productive ThyL-6 cell line established from a patient with thymic carcinoma. (18691242)	Inai K.... Noriki S.	2008	CCL5, IL1A
10	Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma. (17120029)	Ikeda J.... Aozasa K.	2007	VEGFC
11	Thymic carcinoma with epidermal growth factor receptor gene mutations. (16545487)	Yamaguchi H.... Kohno S.	2006	EGFR
12	COX-2 upregulation in thymomas and thymic carcinomas. (16823844)	Rieker R.J.... Kern M.A.	2006	KIT, PTGS2
13	Multimodality therapy and significance of serum CYFRA21-1 for thymic carcinoma. (15870932)	Suzuki M.... Kimura H.	2005	KRT19
14	KIT (CD117) is frequently overexpressed in thymic carcinomas but is absent in thymomas. (14991904)	Pan C.C.... Chiang H.	2004	KIT
15	Thymic carcinoma with overexpression of mutated KIT and the response to imatinib. (15201427)	StrAPbel P.... Marx A.	2004	KIT
16	Intrathyroidal thymic carcinoma: a case report. (12709740)	Tai C.M.... Chang T.C.	2003	TG
17	Expression of calretinin and other mesothelioma-related markers in thymic carcinoma and thymoma. (14652817)	Pan C.C.... Chiang H.	2003	WT1, THBD, TP63
18	Clinical and immunohistochemical study of eight cases with thymic carcinoma. (12049674)	Tomita M.... Onitsuka T.	2002	BCL2, MUC1, NME1
19	CD70 expression in thymic carcinoma. (10800994)	Hishima T.... Koike M.	2000	CD70
20	An autopsy case of thymic carcinoma producing various tumor markers and the examination of 222 autopsy cases of thymic malignant tumor in Japan (10846355)	Takase K.... Kato Y.	2000	ENO2, S100A1
21	Parathyroid-hormone-related-protein-producing thymic carcinoma presenting as a giant extrathoracic mass. (9523373)	Suzuki K.... Abe S.	1998	PTHLH
22	Papillary carcinoma of the thymus: report of four cases of a new microscopic type of thymic carcinoma. (9669349)	Matsuno Y.... Rosai J.	1998	CALB2, TG
23	Neuroendocrine differentiation in thymic epithelial tumors with special reference to thymic carcinoma and atypical thymoma. (9563781)	Hishima T.... Koike M.	1998	CALCA, SYP
24	Neuroendocrine differentiation is a common feature of thymic carcinoma. (9737237)	Lauriola L.... Rosai J.	1998	SYP
25	Thymic carcinoma arising in thymoma is associated with alterations in immunohistochemical profile. (9850173)	Kuo T.T.... Chan J.K.	1998	VIM, KRT7
26	Thymic carcinomas, but not thymomas and carcinomas of other sites, show CD5 immunoreactivity. (9255257)	Dorfman D.M.... Chan J.K.	1997	DNTT
27	Differential diagnosis of thymic carcinoma and lung carcinoma with the use of antibodies to cytokeratins. (8523878)	Fukai I.... Eimoto T.	1995	KRT7
28	CD5 expression in thymic carcinoma. (7519823)	Hishima T.... Koike M.	1994	CD5
29	Thymic carcinoma. A clinicopathologic study of 13 cases. (1689123)	Truong L.D.... Wheeler T.M.	1990	PTPRC, VIM, MUC1

Genes related to thymic carcinoma according to GeneCards:

(show all 36)

id	Symbol	Description	Score	GeneCards Section Context
1	CD5	CD5 molecule	11.0	Publications
2	KRT7	keratin 7	11.0	Publications
3	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
4	SYP	synaptophysin	11.0	Publications
5	CALB2	calbindin 2	11.0	Publications
6	NKX2-1	NK2 homeobox 1	11.0	Publications
7	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
8	NGFR	nerve growth factor receptor	11.0
9	KRT18	keratin 18	11.0
10	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	11.0
11	MUC1	mucin 1, cell surface associated	11.0	Publications
12	ALPP	alkaline phosphatase, placental	11.0	Publications
13	TP63	tumor protein p63	11.0	Publications
14	CEMP1	cementum protein 1	11.0
15	CD70	CD70 molecule	11.0	Publications
16	MSLN	mesothelin	11.0	Publications
17	DNTT	deoxynucleotidyltransferase, terminal	11.0	Publications
18	S100A1	S100 calcium binding protein A1	11.0	Publications
19	SLC7A5	solute carrier family 7 (amino acid transporter light chain, L system), member 5	11.0	Publications
20	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
21	CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	11.0	Publications
22	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
23	KRT19	keratin 19	11.0	Publications
24	TG	thyroglobulin	11.0	Publications
25	THBD	thrombomodulin	11.0	Publications
26	VEGFC	vascular endothelial growth factor C	11.0	Publications
27	VIM	vimentin	11.0	Publications
28	WT1	Wilms tumor 1	11.0	Publications
29	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
30	PTHLH	parathyroid hormone-like hormone	11.0	Publications
31	PTPRC	protein tyrosine phosphatase, receptor type, C	11.0	Publications
32	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
33	IL1A	interleukin 1, alpha	11.0	Publications
34	EGFR	epidermal growth factor receptor	11.0	Publications
35	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
36	BCL2	B-cell CLL/lymphoma 2	11.0	Publications

Pathways related to thymic carcinoma according to GeneDecks:

(show all 41)

id	Pathway	Score	Top Affiliating Genes
1	Rac1 Pathway36	10.4	NGFR, NTRK1
2	Actin-Based Motility by Rho Family GTPases36	10.3	NTRK1, NGFR
3	Cytoskeleton remodeling Keratin filaments10	10.1	KRT19, KRT18, KRT7, VIM
4	Cytoskeleton remodeling_Keratin filaments41	10.0	KRT19, KRT18, KRT7, VIM
5	Akt Signaling36	10.0	KIT, VEGFC, CCL5, NGFR
6	JNK Pathway36	9.9	NGFR, NTRK1, BCL2, KIT
7	Hematopoietic cell lineage20	9.8	KIT, CD5, IL1A, DNTT
8	Apoptosis and survival Role of CDK5 in neuronal death and survival10	9.8	NTRK1, BCL2
9	Cell adhesion Cell-matrix glycoconjugates10	9.7	CEACAM5, MUC1, CCL5
10	eIF2 Pathway36	9.5	EGFR, NTRK1, VEGFC, KIT
11	Apoptotic Pathways in Synovial Fibroblasts36	9.5	EGFR, NGFR, NTRK1, VEGFC, KIT
12	Telomerase Components in Cell Signaling36	9.5	EGFR, NGFR, NTRK1, VEGFC, KIT
13	ERK5 Signaling36	9.4	KIT, VEGFC, NTRK1, NGFR, EGFR
14	PPAR Pathway36	9.4	EGFR, NGFR, NTRK1, VEGFC, KIT
15	Tyrosine Kinases / Adaptors3	9.4	KIT, VEGFC, NTRK1, EGFR
16	Nuclear Receptor Activation by Vitamin-A36	9.4	EGFR, NGFR, NTRK1, VEGFC, KIT
17	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	9.4	NGFR, NTRK1, BCL2
18	Neuroscience3	9.3	SYP, NGFR, NTRK1, PTGS2, ENO2
19	p70S6K Signaling36	9.2	EGFR, NGFR, NTRK1, VEGFC, KIT
20	Pathways in cancer20	9.2	VEGFC, BCL2, NTRK1, EGFR
21	Activation of PKC through GPCR36	9.2	EGFR, NGFR, NTRK1, VEGFC, KIT
22	Endothelin-1 Signaling Pathway36	9.1	EGFR, NTRK1, CCL5, IL1A, KIT
23	p53 Mediated Apoptosis36	9.1	EGFR, NGFR, NTRK1, BCL2, VEGFC, KIT
24	Mitochondrial Apoptosis36	9.0	EGFR, NGFR, NTRK1, BCL2, VEGFC, KIT
25	DHA Signaling36	9.0	EGFR, NGFR, NTRK1, BCL2, VEGFC, KIT
26	Cellular Apoptosis Pathway36	9.0	EGFR, NGFR, NTRK1, BCL2, VEGFC, KIT
27	Molecular Mechanisms of Cancer36	9.0	EGFR, CCL5, BCL2, VEGFC
28	ERK Signaling36	8.8	KIT, VEGFC, IL1A, CCL5, EGFR
29	Renin-Angiotensin Pathway36	8.7	EGFR, NGFR, NTRK1, PTGS2, VEGFC, KIT
30	Cytokine-cytokine receptor interaction20	8.7	EGFR, NGFR, CCL5, IL1A, CD70, VEGFC
31	ILK Signaling36	8.4	EGFR, KRT18, NTRK1, PTGS2, VEGFC, VIM
32	MAPK Signaling36	8.4	EGFR, NGFR, NTRK1, IL1A, BCL2, VEGFC
33	TGF-Beta Pathway36	8.4	EGFR, NGFR, CCL5, IL1A, BCL2, VEGFC
34	MAPK Family Pathway36	8.3	EGFR, NGFR, CCL5, IL1A, BCL2, VEGFC
35	Pancreatic Adenocarcinoma36	8.3	EGFR, NTRK1, PTGS2, BCL2, VEGFC, KIT
36	Tec Kinases Signaling36	8.3	EGFR, NGFR, NTRK1, CCL5, IL1A, BCL2
37	PAK Pathway36	8.2	KIT, EGFR, NGFR, NTRK1, CCL5, IL1A
38	JAK-STAT Pathway36	8.2	EGFR, NGFR, NTRK1, CCL5, IL1A, BCL2
39	Antioxidant Action of Vitamin-C36	8.2	EGFR, NGFR, NTRK1, CCL5, IL1A, BCL2
40	p38 Signaling36	8.2	EGFR, NGFR, NTRK1, CCL5, IL1A, BCL2
41	Rho Family GTPases36	8.0	EGFR, NTRK1, CCL5, IL1A, BCL2, VEGFC

Compounds related to thymic carcinoma according to GeneDecks:

(show top 50)    (show all 176)

id	Compound	Score	Top Affiliating Genes
1	dmso32	9.7	THBD, TG, VIM, ALPP, KRT18
2	toluidine32	9.4	S100A1, PTPRC, VIM, ENO2, KIT
3	agar32	9.3	CEACAM5, VIM, MUC1, NGFR, TG, NME1
4	aspartate32	9.3	NTRK1, THBD, VIM, CEACAM3, DNTT, TG
5	mucicarmine32	9.3	VIM, MUC1, S100A1, CEACAM5, CEACAM3, CALB2
6	choline32 9 18 9	12.3	NGFR, ENO2, SYP, DNTT, ALPP, NTRK1
7	glucose32	9.2	KRT19, KRT7, PTHLH, VEGFC, KIT, SLC7A5
8	ganglioside32	9.2	CEACAM5, PTPRC, NGFR, SYP, VIM, ENO2
9	pge232	9.1	CCL5, EGFR, IL1A
10	methotrexate32 34 42 9 9	13.0	KRT7, DNTT, KIT, VIM, MUC1, CCL5
11	12-o-tetradecanoylphorbol 13-acetate32	8.9	DNTT, PTPRC, PTHLH, IL1A, NTRK1, NGFR
12	glutamate32	8.8	NGFR, VIM, CCL5, ALPP, CALB2, CALCA
13	cysteine32	8.8	NGFR, THBD, SLC7A5, NTRK1, CCL5, S100A1
14	formaldehyde32 18	9.4	NKX2-1, KIT, VIM, MUC1, IL1A, ENO2
15	butyrate32	8.3	NTRK1, ALPP, CALB2, MUC1, WT1, VIM
16	5fluorouracil32	8.3	KIT, BCL2, MUC1, CEACAM5, CEACAM3, EGFR
17	hydrocortisone32 9 9	10.2	CCL5, IL1A, MUC1, CALCA, PTHLH, TG
18	matrigel32	8.0	TP63, CCL5, MUC1, VEGFC, VIM, PTHLH
19	steroid32	8.0	WT1, CEACAM3, TP63, NTRK1, PTHLH, THBD
20	hematoxylin32	8.0	KIT, VIM, MUC1, S100A1, CEACAM5, CEACAM3
21	glycogen32 18	9.0	VIM, KIT, THBD, MUC1, S100A1, CEACAM5
22	acetylcholine32 9 18 9	10.9	CALCA, SYP, TG, NGFR, NTRK1, PTHLH
23	doxorubicin32 34 9 9	10.9	BCL2, TP63, KRT18, EGFR, CEACAM5, VIM
24	retinoid32	7.9	NTRK1, NGFR, KRT7, KRT19, EGFR, THBD
25	hyaluronic acid32 18	8.9	MUC1, CEACAM5, MSLN, IL1A, ENO2, CALB2
26	calcitriol32 42 9 18 9	11.9	IL1A, PTHLH, ALPP, CALCA, NME1, TG
27	oligonucleotide32	7.8	VIM, KIT, VEGFC, WT1, MSLN, NKX2-1
28	b 72332	7.7	CALB2, PTPRC, WT1, KRT7, KRT19, THBD
29	prostaglandin32	7.6	IL1A, PTGS2, CCL5, ENO2, VEGFC, VIM
30	ribonucleic acid32	7.5	KIT, VEGFC, MUC1, IL1A, ENO2, CCL5
31	forskolin32 42 9 9	10.4	VIM, SYP, NKX2-1, THBD, KRT18, WT1
32	lipid32	7.2	NTRK1, SYP, THBD, KRT18, KRT7, NGFR
33	retinoic acid32 42 18	9.2	KRT18, KRT7, WT1, NGFR, NTRK1, PTHLH
34	lactate32	7.1	DNTT, TG, THBD, KRT19, KRT18, NTRK1
35	thymidine32 18	8.0	PTHLH, TP63, CALB2, ALPP, ENO2, IL1A
36	pd 98,05932	6.9	EGFR, NTRK1, ENO2, BCL2, VEGFC, KIT
37	cisplatin32 34 9 9	9.6	PTHLH, NME1, DNTT, SYP, TG, EGFR
38	genistein32 9 18 9	9.6	PTGS2, ALPP, NTRK1, IL1A, EGFR, TG
39	creatinine32	6.5	NTRK1, WT1, KRT18, KRT19, THBD, TG
40	estrogen32	6.4	NKX2-1, NME1, SYP, TG, THBD, EGFR
41	progesterone32 42 9 18 9	10.3	KRT19, EGFR, SYP, NME1, NKX2-1, KRT18
42	calcium32 9 18 9	9.3	PTHLH, CEACAM5, NGFR, KIT, VEGFC, MUC1
43	cycloheximide32	5.7	BCL2, KRT19, ALPP, VIM, TG, THBD
44	nitric oxide32 9 18 9	8.6	PTGS2, PTHLH, NTRK1, NGFR, WT1, KRT18
45	testosterone32 9 18 9	8.6	IL1A, MUC1, VEGFC, VIM, KIT, ENO2
46	dexamethasone32 42 34 9 9	9.6	VIM, PTGS2, ALPP, CCL5, ENO2, IL1A
47	tyrosine32	5.1	SLC7A5, SYP, TG, THBD, EGFR, KRT19
48	serine32	5.0	NME1, NKX2-1, SLC7A5, MUC1, SYP, KIT
49	paraffin32	4.5	PTHLH, BCL2, MUC1, S100A1, CEACAM5, CEACAM3
50	vegf32	3.2	MUC1, NTRK1, NGFR, WT1, KRT7, KRT18

Cellular components related to thymic carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:005882	9.4	VIM, KRT7, KRT18, KRT19, NME1
2	extracellular space	GO:005615	7.0	THBD, EGFR, PTHLH, CALCA, CCL5, IL1A
3	cytoplasm	GO:005737	5.3	PTGS2, PTHLH, WT1, KRT7, KRT18, EGFR

Biological processes related to thymic carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of calcium ion transport into cytosol	GO:010523	9.4	BCL2, CALCA
2	leukocyte cell-cell adhesion	GO:007159	9.3	PTPRC, CALCA, CCL5
3	response to lipopolysaccharide	GO:032496	8.7	IL1A, PTGS2, THBD, NKX2-1
4	response to gamma radiation	GO:010332	8.7	PTPRC, IL1A, BCL2
5	response to drug	GO:042493	8.2	VEGFC, BCL2, ENO2, CCL5, PTGS2, NME1
6	negative regulation of cell proliferation	GO:008285	8.1	NME1, WT1, NTRK1, PTHLH, PTGS2, IL1A

Molecular functions related to thymic carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane signaling receptor activity	GO:004888	9.3	CD5, NGFR, EGFR, THBD
2	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.3	EGFR, NTRK1, KIT
3	identical protein binding	GO:042802	8.3	NME1, SYP, EGFR, TP63, S100A1, BCL2
4	protein homodimerization activity	GO:042803	8.0	NTRK1, PTGS2, CCL5, ENO2, S100A1, BCL2
5	protein binding	GO:005515	4.3	NKX2-1, PTPRC, NTRK1, NGFR, WT1, KRT7