MCID: THY022
MIFTS: 55

Thymic Carcinoma malady

Cancer category

Summaries for Thymic Carcinoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Thymic carcinoma is a rare type of thymus gland cancer. It usually spreads, has a high risk of... more...

MalaCards: Thymic Carcinoma, also known as malignant thymoma, is related to thymoma and neuroendocrine carcinoma, and has symptoms including hyperhidrosis/increased sweating, respiratory distress/dyspnea/respiratory failure/lung volume reduction and asthenia/fatigue/weakness. An important gene associated with Thymic Carcinoma is CD5 (CD5 molecule), and among its related pathways are Hematopoietic cell lineage and Neuroscience. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include ovary, brain and kidney, and related mouse phenotypes are integument and no phenotypic analysis.

Aliases & Classifications for Thymic Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Characteristics (Orphanet epidemiological data):

49
thymic carcinoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Any age


Aliases & Descriptions:

thymic carcinoma 8 10 45 49 61
malignant thymoma 8 49
thymoma, malignant 8


External Ids:

Disease Ontology8 DOID:3284
MeSH35 D013945
NCIt40 C7612
SNOMED-CT57 128717008, 15949004
ICD10 via Orphanet26 C37
SNOMED-CT via Orphanet58 128717008, 15949004, 444374006 444596001, more
UMLS via Orphanet62 C0205969, C1322286

Related Diseases for Thymic Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Thymic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.3TP63, CEACAM3, CD5, NGFR, DNTT, NTRK1
2neuroendocrine carcinoma30.7TP63, KRT7, KRT18, KRT19, KIT, MUC1
3acute leukemia30.2KIT, DNTT
4mucoepidermoid carcinoma30.2TP63, KRT7, MUC1, S100A1
5adenoid cystic carcinoma30.2TP63, CEACAM3, KRT7, KRT19, KIT, MUC1
6squamous cell carcinoma30.2TP63, ALPP, CEACAM3, MSLN, KRT7, KRT18
7adenoma30.0TP63, CEACAM3, KRT7, KRT18, KRT19, NME1
8spindle cell carcinoma29.9TP63, MUC1
9large cell carcinoma29.9TP63, CEACAM3, KRT7, SYP, NKX2-1
10papillary carcinoma29.9TP63, CEACAM3, KRT7, KRT18, KRT19, NME1
11adenocarcinoma29.9TP63, CEACAM3, MSLN, KRT7, KRT18, KRT19
12thymic neuroendocrine carcinoma10.5
13type c thymoma10.4
14combined thymoma10.4
15cortical thymoma10.3
16thymic epithelial neoplasm10.3
17chronic mucocutaneous candidiasis10.2
18cardiac tamponade10.2
19cushing's syndrome10.2
20thymic epithelial tumor10.2
21polymyositis10.2
22giant cell myocarditis10.2
23limbic encephalitis10.2
24paraneoplastic syndromes10.2
25parathyroid carcinoma10.1
26lymphoepithelioma-like thymic carcinoma10.1
27n syndrome10.1
28aplastic anemia10.1
29graft versus host disease10.0
30coronary artery disease,10.0
31primary hyperparathyroidism10.0
32alopecia universalis10.0
33good syndrome10.0
34nocardiosis10.0
35malignant type a thymoma10.0
36malignant type ab thymoma10.0
37ectopic thymus10.0
38epidermodysplasia verruciformis10.0
39alopecia10.0
40t-cell leukemia10.0
41lambert syndrome10.0
42diffuse panbronchiolitis10.0
43steroid-resistant nephrotic syndrome10.0
44dysautonomia10.0
45myokymia10.0
46cardiogenic shock10.0
47tolosa-hunt syndrome10.0
48bone carcinoma10.0
49noninvasive malignant thymoma10.0
50invasive malignant thymoma10.0

Graphical network of the top 20 diseases related to Thymic Carcinoma:



Diseases related to thymic carcinoma

Clinical Features for Thymic Carcinoma

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 13)
  • hyperhidrosis/increased sweating
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • asthenia/fatigue/weakness
  • cutaneous edema
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • thoracic/chest pain
  • cough
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • palpebral edema/periorbital edema
  • mediastinal/hilar adenopathies
  • thymus/thymic neoplasm/tumor/carcinoma/cancer/thymoma
  • myasthenia
  • diaphragmatic palsy

Drugs & Therapeutics for Thymic Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Thymic Carcinoma

Drug clinical trials:

Search ClinicalTrials for Thymic Carcinoma

Search NIH Clinical Center for Thymic Carcinoma

Search CenterWatch for Thymic Carcinoma

Genetic Tests for Thymic Carcinoma

Anatomical Context for Thymic Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Thymic Carcinoma:

33
Ovary, Brain, Kidney, Lymph node, Lung, Thymus, Skeletal muscle, Pancreas, Thyroid, Breast, Myeloid, Monocytes, T cells, Trachea, Bronchial epithelium, Pituitary

Animal Models for Thymic Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Thymic Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.2NME1, KRT19
2MP:00030129.6NKX2-1, SYP, NTRK1, MUC1, CD5, KIT
3MP:00020069.4TP63, KRT19, KIT, NME1, MUC1, NKX2-1
4MP:00028738.8CALB2, TP63, ALPP, MSLN, KRT19, KIT

Publications for Thymic Carcinoma

Sources:
51PubMed
See all sources

Articles related to Thymic Carcinoma:

(show top 50)    (show all 349)
idTitleAuthorsYear
1
Recurrence of thymic neuroendocrine carcinoma 24 years after total excision: A case report. (23946793)
2013
2
Thymic carcinoma: a multivariate analysis of factors predictive of survival in 290 patients. (23141529)
2013
3
Molecular aspects of thymic carcinoma. (22921473)
2012
4
Thymic carcinoma: outcomes after surgical resection. (22421590)
2012
5
Treatment updates in advanced thymoma and thymic carcinoma. (22961051)
2012
6
Thymic carcinoma, part 1: a clinicopathologic and immunohistochemical study of 65 cases. (22706865)
2012
7
Promising efficacy of sorafenib in a relapsed thymic carcinoma with C-KIT exon 11 deletion mutation. (20970876)
2011
8
MUC1 expression in thymic epithelial tumors: MUC1 may be useful marker as differential diagnosis between type B3 thymoma and thymic carcinoma. (21253760)
2011
9
Thymic carcinoma: current and future therapeutic interventions. (20629617)
2010
10
Combined etoposide, ifosfamide, and cisplatin in the treatment of patients with advanced thymoma and thymic carcinoma. A French experience. (20521356)
2010
11
S-1 is an active anticancer agent for advanced thymic carcinoma. (20951466)
2010
12
Imatinib mesylate in patients with WHO B3 thymomas and thymic carcinomas. (20197733)
2009
13
Comparison of patterns of relapse in thymic carcinoma and thymoma. (19577051)
2009
14
Long lasting response to the multikinase inhibitor bay 43-9006 (Sorafenib) in a heavily pretreated metastatic thymic carcinoma. (19461405)
2009
15
Immunohistochemical differential diagnosis between thymic carcinoma and type B3 thymoma: diagnostic utility of hypoxic marker, GLUT-1, in thymic epithelial neoplasms. (19648882)
2009
16
Spontaneous mediastinal haemorrhage linked with thymic carcinoma and myelodysplasia: a case report. (19830017)
2009
17
Videothoracoscopic resection of encapsulated thymic carcinoma: retrospective comparison of the results between thoracoscopy and open methods. (18512103)
2008
18
Cytology of metastatic thymic well-differentiated neuroendocrine carcinoma (thymic carcinoid) in pleural fluid: report of a case. (18418883)
2008
19
Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma. (17120029)
2007
20
Intracranial leptomeningeal metastasis from thymic carcinoma: case report and review. (17537485)
2007
21
Metastatic thymic neuroendocrine carcinoma presenting as a pancreatic tumor. (17366416)
2006
22
Metastatic breast lesion from thymic carcinoma. (16998109)
2006
23
Cerebral involvement of metastatic thymic carcinoma. (16132513)
2005
24
Cardiac tamponade as manifestation of advanced thymic carcinoma. (15761459)
2005
25
Undifferentiated large cell carcinoma of the thymus associated with Castleman disease-like reaction: a distinctive type of thymic neoplasm characterized by an indolent behavior. (15767803)
2005
26
Multimodality therapy for thymic carcinoma (TCA): results of a 30-year single-institution experience. (14758136)
2004
27
Concurrent chemoradiotherapy for unresectable thymic carcinoma. (15508874)
2004
28
Translocation (11;15;19): a highly specific chromosome rearrangement associated with poorly differentiated thymic carcinoma in young patients. (12796605)
2003
29
Microscopic pulmonary tumour embolism: an unusual presentation of thymic carcinoma. (12410327)
2002
30
Multiple brain metastases from "lymphoepithelioma-like" thymic carcinoma: a combined stereotactic-radiosurgical approach. (11358599)
2001
31
Thymic carcinoma with tumor thrombus into the superior vena cava. (11431955)
2001
32
Combined etoposide, ifosfamide, and cisplatin in the treatment of patients with advanced thymoma and thymic carcinoma: an intergroup trial. (11391579)
2001
33
Thymic carcinoma--analysis of nineteen clinicopathological studies. (11028718)
2000
34
Combined partial sternectomy for thymic carcinoma. (11030132)
2000
35
Radiotherapy for invasive thymoma and thymic carcinoma. Clinicopathological review. (10392168)
1999
36
Role of zinc and alpha2 macroglobulin on thymic endocrine activity and on peripheral immune efficiency (natural killer activity and interleukin 2) in cervical carcinoma. (9888464)
1999
37
Immunoreactivity of a new CD5 antibody with normal epithelium and malignant tumors including thymic carcinoma. (9930146)
1999
38
Late onset immunodeficiency in a patient with recurrent thymic carcinoma and myasthenia gravis. (9619646)
1998
39
Papillary carcinoma of the thymus: report of four cases of a new microscopic type of thymic carcinoma. (9669349)
1998
40
TI-201 uptake in thymic carcinoma. (8741900)
1996
41
Thymic carcinoma: case reports and review. (8770829)
1996
42
Thymic carcinoma with a defective Epstein-Barr virus encoding the BZLF1 trans-activator. (8014523)
1994
43
Hypertrophic pulmonary osteoarthropathy in a child with thymic carcinoma: an unusual presentation in childhood. (8202038)
1994
44
Well-differentiated thymic carcinoma: a clinico-pathological study. (1549907)
1992
45
In situ localization of Epstein-Barr virus in thymic carcinoma. (1323108)
1992
46
Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma. (2040007)
1991
47
Thymic carcinoma. A clinicopathologic study of 13 cases. (1689123)
1990
48
An autopsy case of a cystic variant of thymic carcinoma mimicking a thymic cyst. (2113743)
1990
49
Association of Epstein-Barr virus with thymic carcinoma. (2985993)
1985
50
Thymic carcinoma. Five distinctive histological variants. (7125053)
1982

Genetic Variations for Thymic Carcinoma

Expression for genes affiliated with Thymic Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Thymic Carcinoma

Search GEO for disease gene expression data for Thymic Carcinoma.

Pathways for genes affiliated with Thymic Carcinoma

Sources:
30KEGG, 4Cell Signaling Technology, 12EMD Millipore
See all sources

Pathways related to Thymic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1KIT, DNTT, CD5
210.0NGFR, NKX2-1, SYP, NTRK1
310.0KRT19, KRT18, KRT7

Compounds for genes affiliated with Thymic Carcinoma

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Thymic Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8CALB2
2butyrate4510.6DNTT, CALB2
3glutamate4510.5NGFR, NTRK1
4reticulin4510.5SYP, MUC1, KRT7
5cyanine4510.4CEACAM3, CALB2
6glycogen45 2411.4SYP, KIT, KRT18, KRT7
7dexamethasone45 50 29 1113.3ALPP, NKX2-1, NME1, KRT18
8dutp4510.3KRT18, SYP, DNTT, NTRK1
9gnf 58376010.3NGFR, NTRK1
10gold4510.3CEACAM3, KRT18, KIT, MUC1, SYP
11p0034510.2NTRK1, KRT19, TP63, KIT
12serine4510.2NKX2-1, NME1, SYP, KRT19, ALPP
13p0024510.2NME1, KIT, KRT18, KRT19
145fluorouracil4510.2NME1, KRT18, KIT, CEACAM3, MUC1
15fitc4510.2KRT18, KRT19, DNTT
16ribonucleic acid4510.1KIT, NKX2-1, NME1, KRT19, MUC1
17ethanol45 50 11 2413.1CALB2, MUC1, NGFR, KRT18, SYP
18methotrexate45 50 1112.1CEACAM3, KIT, DNTT, MUC1, KRT7
19choline45 11 2412.1ALPP, NGFR, DNTT, NTRK1, SYP, CALB2
20acetylcholine45 50 29 11 2414.1NGFR, SYP, S100A1, CALB2, NTRK1
21dmso4510.0DNTT, MUC1, NME1, ALPP, TP63, KRT18
22retinoid4510.0NTRK1, NGFR, ALPP, KRT7, KRT18, KRT19
23formaldehyde45 2411.0KRT19, NKX2-1, SYP, KRT18, KRT7, MUC1
24bromodeoxyuridine4510.0TP63, KRT19, KRT18, DNTT
25creatinine4510.0KRT18, NME1, SYP, NTRK1, KRT19, CEACAM3
26indium459.9CEACAM3, MUC1
27mucicarmine459.9CALB2, S100A1, SYP, MUC1, KRT7, CEACAM3
28steroid459.9KRT18, KRT19, NME1, NGFR, SYP, NKX2-1
29hyaluronic acid45 2410.9MUC1, CALB2, MSLN, KRT19
30matrigel459.9KRT19, NME1, KRT18, TP63, MUC1, KRT7
31cisplatin45 50 60 1112.9NME1, TP63, ALPP, KRT19, MUC1, DNTT
32zinc45 2410.9NGFR, NKX2-1, KRT18, S100A1, CALB2, DNTT
33cysteine459.8SYP, NTRK1, NGFR, NME1, S100A1, KIT
34forskolin45 50 1111.8MUC1, NKX2-1, NGFR, SYP, KRT18
35oligonucleotide459.8NTRK1, DNTT, NGFR, NME1, KIT, KRT18
36glucose459.8MUC1, KRT18, KRT7, CEACAM3, NGFR, KRT19
37lactate459.8CEACAM3, NTRK1, DNTT, NME1, KIT, KRT19
38aspartate459.8NTRK1, CEACAM3, ALPP, KRT19, KIT, NME1
39cholesterol45 29 11 2412.8MUC1, NGFR, DNTT, CEACAM3, SYP, ALPP
40testosterone45 60 11 2412.6TP63, CALB2, SYP, KRT7, NTRK1, MUC1
41nitric oxide45 11 2411.5CALB2, SYP, NTRK1, DNTT, NGFR, MUC1
42thymidine45 2410.4DNTT, CEACAM3, KRT18, KRT19, KIT, NME1
43b 723459.4TP63, MUC1, SYP, NKX2-1, S100A1, CALB2
44hematoxylin459.4KIT, KRT18, KRT7, CEACAM3, TP63, KRT19
45calcium45 50 11 2412.3NGFR, MUC1, NME1, NTRK1, SYP, S100A1
46vegf459.2NTRK1, NGFR, MUC1, KIT, KRT18, SYP
47progesterone45 60 29 11 2413.2NTRK1, SYP, NKX2-1, S100A1, CALB2, NGFR
48retinoic acid45 2410.1MUC1, NGFR, DNTT, NTRK1, SYP, NKX2-1
49tyrosine459.1TP63, NTRK1, NGFR, MUC1, CD5, NME1
50paraffin458.7S100A1, NKX2-1, SYP, NTRK1, DNTT, NGFR

GO Terms for genes affiliated with Thymic Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.0KRT7, KRT18, KRT19
2cell surfaceGO:0099869.5ALPP, MSLN, MUC1, NGFR, NTRK1

Biological processes related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2TP63, MUC1

Molecular functions related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nerve growth factor bindingGO:04840610.3NGFR, NTRK1
2protein bindingGO:0055158.4TP63, S100A1, NKX2-1, NTRK1, NGFR, MUC1

Products for genes affiliated with Thymic Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thymic Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet