MCID: THY022
MIFTS: 48

Thymic Carcinoma malady

Cancer diseases category
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Summaries for Thymic Carcinoma

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33MalaCards
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MalaCards: Thymic Carcinoma, also known as thymoma, malignant, is related to thymoma and adenoid cystic carcinoma. An important gene associated with Thymic Carcinoma is CD5 (CD5 molecule), and among its related pathways are Hematopoietic cell lineage and Neuroscience. The compounds s 100 and reticulin have been mentioned in the context of this disorder. Affiliated tissues include thymus, brain and thyroid, and related mouse phenotypes are no phenotypic analysis and digestive/alimentary.

Aliases & Classifications for Thymic Carcinoma

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

thymic carcinoma 8 62
thymoma, malignant 8
malignant thymoma 8


External Ids:

Disease Ontology8 DOID:3284
MeSH35 D013945
SNOMED-CT58 15949004, 128717008
NCIt40 C7612

Related Diseases for Thymic Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Thymic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.3CD5, NGFR, NKX2-1
2adenoid cystic carcinoma30.0MUC1, KIT
3thymus cancer30.0KRT18, NKX2-1, KIT, MUC1, CD5, NGFR
4adenoma30.0KRT18, MUC1, SYP, NKX2-1
5papillary carcinoma29.9NKX2-1, SYP, KRT18, MUC1
6adenocarcinoma29.8MUC1, NGFR, KRT18, SYP, NKX2-1
7lymphoepithelioma-like thymic carcinoma10.3
8candidiasis10.3
9thymic epithelial neoplasm10.3
10chronic mucocutaneous candidiasis10.3
11myocarditis10.3
12cardiac tamponade10.2
13cushing's syndrome10.2
14dermatomyositis10.2
15mediastinitis10.2
16myasthenia gravis10.2
17thyroiditis10.2
18polymyositis10.2
19thymic epithelial tumor10.2
20intestinal pseudo-obstruction10.2
21giant cell myocarditis10.2
22limbic encephalitis10.2
23cortical thymoma10.2
24adenoiditis10.2
25aplastic anemia10.2
26cervicitis10.2
27leukemia10.2
28type c thymoma10.2
29paraneoplastic syndromes10.2
30glomus tumor10.1SYP
31pulmonary blastoma10.1NKX2-1
32perineurioma10.1MUC1
33hemangioma10.1NKX2-1
34merkel cell carcinoma10.1NKX2-1, SYP
35choroid plexus papilloma10.1SYP, MUC1
36sertoli cell tumor10.1SYP, MUC1
37rhabdoid tumor10.1SYP, MUC1
38large cell carcinoma10.1NKX2-1, SYP
39hemangioblastoma10.1MUC1, SYP
40tubular adenocarcinoma10.1MUC1, SYP
41papillary adenocarcinoma10.1NKX2-1, MUC1
42sex cord-gonadal stromal tumor10.0NKX2-1, MUC1
43adenosquamous carcinoma10.0NKX2-1, MUC1
44abrikosov's tumor10.0NKX2-1, MUC1
45malignant pleural mesothelioma10.0NKX2-1, MUC1
46chordoma10.0KRT18, MUC1
47angiosarcoma10.0KRT18, MUC1
48pleomorphic adenoma10.0MUC1, KRT18
49dermatofibrosarcoma protuberans10.0MUC1, KIT
50neuroendocrine tumor10.0NKX2-1, SYP

Graphical network of the top 20 diseases related to Thymic Carcinoma:



Diseases related to thymic carcinoma

Symptoms for Thymic Carcinoma

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Drugs & Therapeutics for Thymic Carcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Thymic Carcinoma

Search NIH Clinical Center for Thymic Carcinoma

Genetic Tests for Thymic Carcinoma

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Anatomical Context for Thymic Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Thymic Carcinoma:

33
Thymus, Brain, Thyroid, Lung, Breast, Pituitary, Pancreas, Kidney, Lymph node, Testes, Myeloid, Monocytes, Trachea, Bone

Animal Models for Thymic Carcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Thymic Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1CD5, KIT, NKX2-1, SYP, MUC1
2MP:00053818.1KIT, NKX2-1, MUC1, NGFR
3MP:00053707.7NGFR, MUC1, KIT, KRT18
4MP:00028737.6NGFR, MUC1, SYP, KIT, CD5

Publications for Thymic Carcinoma

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52PubMed
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Articles related to Thymic Carcinoma:

(show top 50)    (show all 307)
idTitleAuthorsYear
1
Pure white cell aplasia in a patient with thymic carcinoma. (24137702)
2013
2
Successful chemotherapy with Carboplatin and s-1 for thymic carcinoma: a case report. (24348388)
2013
3
Stiff man syndrome with invasive thymic carcinoma. (23432176)
2013
4
Early-stage thymic carcinoma: is adjuvant therapy required? (23585943)
2013
5
Importance of lymph node dissection in thymic carcinoma. (23806232)
2013
6
Long lasting efficacy of sorafenib in a heavily pretreated patient with thymic carcinoma. (23090205)
2012
7
Thymoma and thymic carcinoma. (22237733)
2012
8
Immunohistochemical analysis of thymic carcinoma focusing on the possibility of molecular targeted and hormonal therapies. (23054618)
2012
9
Management and outcomes of relapse after treatment for thymoma and thymic carcinoma. (22115206)
2011
10
Large thymic carcinoma presenting with right ventricular failure: a case report. (21938989)
2011
11
Promising efficacy of sorafenib in a relapsed thymic carcinoma with C-KIT exon 11 deletion mutation. (20970876)
2011
12
Thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic study of 7 cases. (21677542)
2011
13
Prognostic effect of stromal lymphocyte infiltration in thymic carcinoma. (21492951)
2011
14
Metastatic skull base tumor from thymic carcinoma mimicking Tolosa-Hunt syndrome. (20587979)
2010
15
Imatinib mesylate in patients with WHO B3 thymomas and thymic carcinomas. (20197733)
2009
16
Cerebellar ataxia associated with neuroendocrine thymic carcinoma and GAD antibodies. (19448100)
2009
17
Thymic carcinoma: current concepts and histologic features. (18514123)
2008
18
Endobronchial ultrasound appearance of pulmonary artery thrombus in a patient with thymic carcinoma. (17805065)
2007
19
A case of mixed connective tissue disease complicated with thymic carcinoma and Hashimoto's thyroiditis. (17278025)
2007
20
Thymic carcinoma. (17225487)
2007
21
COX-2 upregulation in thymomas and thymic carcinomas. (16823844)
2006
22
Cerebral involvement of metastatic thymic carcinoma. (16132513)
2005
23
Aberrant methylation: common in thymic carcinomas, rare in thymomas. (16273266)
2005
24
Cardiac tamponade as manifestation of advanced thymic carcinoma. (15761459)
2005
25
Ga-67 uptake in thymic carcinoma: utility of Ga-67 scintigraphy in patient management. (14734918)
2004
26
Multimodality therapy for thymic carcinoma (TCA): results of a 30-year single-institution experience. (14758136)
2004
27
Thymic carcinoma: state of the art review. (15183468)
2004
28
Concurrent chemoradiotherapy for unresectable thymic carcinoma. (15508874)
2004
29
Thymic carcinoma: a clinicopathological and immunohistological study of 19 cases. (15049903)
2004
30
Thymic carcinoma presenting as cranial metastasis with intradural and extracranial extension: case report. (14683559)
2004
31
Efficacy of docetaxel as a second-line chemotherapy for thymic carcinoma. (15608443)
2004
32
Acquired myasthenia gravis associated with a non-invasive thymic carcinoma in a dog. (15086092)
2003
33
Postoperative radiotherapy in thymic carcinoma: treatment results and prognostic factors. (11849804)
2002
34
Metastatic thymic carcinoma in a digit: a case report. (11119681)
2000
35
Platinum-based chemotherapy with or without thoracic radiation therapy in patients with unresectable thymic carcinoma. (11095135)
2000
36
Thymic carcinoma--analysis of nineteen clinicopathological studies. (11028718)
2000
37
Thymoma and thymic carcinoma. (10366159)
1999
38
Radiotherapy for invasive thymoma and thymic carcinoma. Clinicopathological review. (10392168)
1999
39
Parathyroid-hormone-related-protein-producing thymic carcinoma presenting as a giant extrathoracic mass. (9523373)
1998
40
Late onset immunodeficiency in a patient with recurrent thymic carcinoma and myasthenia gravis. (9619646)
1998
41
Effective treatment of thymic carcinoma with operation and combination chemotherapy against acute monocyte leukemia: case report and review of the literature. (9793029)
1998
42
High frequency of p53 protein expression in thymic carcinoma but not in thymoma. (9374384)
1997
43
Assessment of residual tumor viability in thymic carcinoma by sequential thallium-201 SPECT: comparison with CT and biopsy findings. (7931668)
1994
44
Thymic carcinoma associated with pinealoma and terminating with peroxidase-negative acute myeloid leukemia. (1392188)
1992
45
Relapsing thymic carcinoma during pregnancy. (1326220)
1992
46
Primary thymic carcinoma and its association with dermatomyositis and pure red cell aplasia. (1512098)
1992
47
Establishment and characterization of a thymic carcinoma cell line (Ty-82) carrying t(15;19)(q15;p13) chromosome abnormality. (1730520)
1992
48
Thymic carcinoma. A clinicopathologic study of 13 cases. (1689123)
1990
49
Successful treatment of metastatic thymic carcinoma with cisplatin, vinblastine, bleomycin, and etoposide chemotherapy. (1699650)
1990
50
Histochemical and immunohistochemical evidence of glandular differentiation in thymic carcinoma. (2477989)
1989

Variations for Thymic Carcinoma

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Expression for genes affiliated with Thymic Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thymic Carcinoma

Search GEO for disease gene expression data for Thymic Carcinoma.

Pathways for genes affiliated with Thymic Carcinoma

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50PathCards, 30KEGG, 5Cell Signaling Technology, 53QIAGEN
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Pathways related to Thymic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CD5, KIT
28.8NKX2-1, SYP, NGFR
3
Show member pathways
8.0KRT18, KIT, MUC1, NGFR

Compounds for genes affiliated with Thymic Carcinoma

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45Novoseek, 51PharmGKB, 24HMDB, 11DrugBank, 3BitterDB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Thymic Carcinoma according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1s 100459.9MUC1, SYP
2reticulin459.9SYP, MUC1
3dutp459.8KRT18, SYP
4lithium45 51 24 1112.7SYP, MUC1
5methylcellulose459.6KRT18, KIT
6trastuzumab45 51 1111.5KIT, MUC1
7mucicarmine459.5NKX2-1, SYP, MUC1
8b 723459.5NKX2-1, SYP, MUC1
9chloroquine45 3 51 29 1113.5SYP, KIT
10ganglioside459.4NGFR, SYP
11dbc-amp459.4SYP, NGFR
12cytarabine45 51 1111.3KIT, MUC1
13creatinine459.3KRT18, SYP, MUC1
14ribonucleic acid459.2MUC1, NKX2-1, KIT
155fluorouracil459.2MUC1, KIT, KRT18
16catecholamine459.1NGFR, SYP
17actinomycin d459.1MUC1, KIT, KRT18
18p002459.0KRT18, KIT
19dopamine45 29 24 1112.0NGFR, SYP, KRT18
20agar459.0KRT18, MUC1, NGFR
21matrigel459.0NGFR, MUC1, KRT18
22phosphotyrosine459.0NGFR, SYP, KIT
23histamine45 29 2410.9KIT, SYP, NGFR
24leucine458.8NGFR, SYP, KIT
25gold458.8MUC1, SYP, KIT, KRT18
26glycogen45 249.8MUC1, SYP, KIT, KRT18
27testosterone45 61 24 1111.8KRT18, KIT, SYP, MUC1
28cholesterol45 29 24 1111.7SYP, MUC1, NGFR
29cyclic amp45 249.7NKX2-1, SYP, MUC1, NGFR
30ethanol45 51 24 1111.6KRT18, SYP, MUC1, NGFR
31lipid458.5NGFR, MUC1, SYP, KRT18
32oligonucleotide458.4NGFR, NKX2-1, KIT, KRT18
33cysteine458.4KIT, SYP, MUC1, NGFR
34formaldehyde45 249.4MUC1, SYP, NKX2-1, KIT, KRT18
35thymidine45 249.4NGFR, MUC1, KIT, KRT18
36glucose458.3NGFR, MUC1, KIT, KRT18
37forskolin45 51 1110.2NGFR, MUC1, SYP, NKX2-1, KRT18
38dexamethasone45 51 29 1111.2NGFR, MUC1, SYP, NKX2-1, KRT18
39steroid458.1NGFR, SYP, NKX2-1, KIT, KRT18
40calcium45 51 24 1111.1NGFR, MUC1, SYP, KIT, CD5
41vegf458.0KRT18, KIT, SYP, MUC1, NGFR
42nitric oxide45 24 1110.0NGFR, MUC1, SYP, KIT, KRT18
43threonine457.9NGFR, MUC1, NKX2-1, KIT, KRT18
44hematoxylin457.6KRT18, KIT, NKX2-1, SYP, MUC1, NGFR
45progesterone45 29 61 24 1111.6NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
46estrogen457.6NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
47retinoic acid45 248.6NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
48serine457.5NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
49paraffin457.2NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
50tyrosine457.2NGFR, MUC1, SYP, NKX2-1, KIT, KRT18

GO Terms for genes affiliated with Thymic Carcinoma

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16Gene Ontology
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Biological processes related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic signaling pathwayGO:0971909.3CD5, NGFR

Molecular functions related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.3CD5, NGFR
2protein bindingGO:0055156.9CD5, KRT18, KIT, NKX2-1, MUC1, NGFR

Products for genes affiliated with Thymic Carcinoma

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  • Antibodies
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Sources for Thymic Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet