MCID: THY022
MIFTS: 51

Thymic Carcinoma malady

Cancer diseases category

Summaries for Thymic Carcinoma

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32MalaCards
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MalaCards: Thymic Carcinoma, also known as thymoma, malignant, is related to thymoma and neuroendocrine carcinoma. An important gene associated with Thymic Carcinoma is CD5 (CD5 molecule), and among its related pathways are Hematopoietic cell lineage and Neuroscience. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include thymus, lung and thyroid, and related mouse phenotypes are integument and no phenotypic analysis.

Aliases & Classifications for Thymic Carcinoma

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8Disease Ontology, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

thymic carcinoma 8 60
thymoma, malignant 8
malignant thymoma 8


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Disease Ontology8 DOID:3284
MeSH34 D013945
SNOMED-CT56 128717008, 15949004
NCIt39 C7612

Related Diseases for Thymic Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Thymic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.2TP63, CEACAM3, CD5, NGFR, DNTT, NTRK1
2neuroendocrine carcinoma30.6TP63, KRT7, KRT18, KRT19, KIT, MUC1
3thymus cancer30.3TP63, ALPP, CEACAM3, KRT7, KRT18, KIT
4acute leukemia30.1KIT, DNTT
5mucoepidermoid carcinoma30.1TP63, KRT7, MUC1, S100A1
6adenoid cystic carcinoma30.1TP63, CEACAM3, KRT7, KRT19, KIT, MUC1
7leukemia30.1ALPP, KIT, NME1, CD5, NGFR, DNTT
8squamous cell carcinoma30.1TP63, ALPP, CEACAM3, MSLN, KRT7, KRT18
9adenoma29.9TP63, CEACAM3, KRT7, KRT18, KRT19, NME1
10hepatitis29.9ALPP
11spindle cell carcinoma29.9TP63, MUC1
12meningioma29.9MUC1, SYP, S100A1, CALB2
13large cell carcinoma29.9TP63, CEACAM3, KRT7, SYP, NKX2-1
14neuroendocrine tumor29.9CEACAM3, KRT19, NTRK1, SYP, NKX2-1
15sarcoma29.9TP63, KIT, MUC1, NTRK1, S100A1, CALB2
16neuroblastoma29.9NME1, NGFR, NTRK1, SYP
17papillary carcinoma29.9TP63, CEACAM3, KRT7, KRT18, KRT19, NME1
18adenocarcinoma29.9TP63, CEACAM3, MSLN, KRT7, KRT18, KRT19
19combined thymoma10.3
20lymphoepithelioma-like thymic carcinoma10.3
21candidiasis10.3
22cortical thymoma10.3
23chronic mucocutaneous candidiasis10.2
24myocarditis10.2
25cardiac tamponade10.2
26cushing's syndrome10.2
27lymphoepithelioma-like carcinoma10.2
28dermatomyositis10.2
29mediastinitis10.2
30myasthenia gravis10.2
31thyroiditis10.2
32intestinal obstruction10.1
33intestinal pseudo-obstruction10.1
34parathyroid carcinoma10.1
35adenoiditis10.1
36aplastic anemia10.1
37cervicitis10.1
38type c thymoma10.1
39leydig cell tumor10.0CALB2
40pituitary adenoma10.0SYP
41kidney cancer10.0KRT7
42hemangioma10.0NKX2-1
43adenomatoid tumor10.0CALB2
44gastritis10.0KRT18
45pancreatitis10.0ALPP
46colon adenocarcinoma10.0CALB2
47germ cell tumors10.0KIT
48interstitial lung disease10.0MUC1
49gingivitis10.0ALPP
50arthritis10.0ALPP

Graphical network of the top 20 diseases related to Thymic Carcinoma:



Diseases related to thymic carcinoma

Clinical Features for Thymic Carcinoma

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Drugs & Therapeutics for Thymic Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Thymic Carcinoma

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Anatomical Context for Thymic Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Thymic Carcinoma:

32
Thymus, Lung, Thyroid, Brain, Testes, Breast, Pituitary, Bone, Myeloid, Pancreas, Monocytes, Skeletal muscle, Lymph node, Kidney, Ovary, Trachea

Animal Models for Thymic Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thymic Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.2KRT19, NME1
2MP:00030129.6NKX2-1, SYP, NTRK1, MUC1, CD5, KIT
3MP:00020069.4NKX2-1, MUC1, NME1, KIT, KRT19, TP63
4MP:00028738.8TP63, CALB2, S100A1, SYP, NTRK1, DNTT

Publications for Thymic Carcinoma

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50PubMed
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Articles related to Thymic Carcinoma:

(show top 50)    (show all 348)
idTitleAuthorsYear
1
Intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation; comparison with thymic lymphoepithelioma-like carcinoma and a possibility of development from a multipotential stem cell. (23176314)
2013
2
Cytoreductive surgery combined with hyperthermic intrapleural chemotherapy to treat thymoma or thymic carcinoma with pleural dissemination. (23690692)
2013
3
Role of PAX-8, CD5, and CD117 in Distinguishing Thymic Carcinoma from Poorly Differentiated Lung Carcinoma. (23958552)
2013
4
Chemotherapy for thymic carcinoma and advanced thymoma in adults. (23970462)
2013
5
"Pseudocavitation" in thymic carcinoma during treatment with sunitinib. (23486269)
2013
6
Protein expression and gene copy number changes of receptor tyrosine kinase in thymomas and thymic carcinomas. (22700994)
2012
7
Anaplastic thymic carcinoma: a clinicopathologic and immunohistochemical study of 6 cases. (22055398)
2012
8
Micronodular thymic carcinoma with lymphoid hyperplasia: a clinicopathological and immunohistochemical study of five cases. (22388764)
2012
9
Management and outcomes of relapse after treatment for thymoma and thymic carcinoma. (22115206)
2011
10
Thymic large-cell neuroendocrine carcinoma: a disease neglected in the ESMO guideline? (22024725)
2011
11
Successful S-1 monotherapy for chemorefractory thymic carcinoma. (21273614)
2011
12
Masaoka stage and histologic grade predict prognosis in patients with thymic carcinoma. (20172153)
2010
13
Erythrocytosis caused by erythropoietin-producing thymic carcinoma. (20179983)
2010
14
Thymic carcinoma in myasthenia gravis developing years after thymectomy. (19533649)
2009
15
Mucoepidermoid thymic carcinoma: a challenging mediastinal aspirate. (19217053)
2009
16
Thymic carcinoma: current concepts and histologic features. (18514123)
2008
17
Response of a thymic mucoepidermoid carcinoma to combination chemotherapy with cisplatin and irinotecan: a case report. (17707547)
2008
18
Intrapericardial primary thymic carcinoma in a 73-year-old man. (19156242)
2008
19
COX-2 upregulation in thymomas and thymic carcinomas. (16823844)
2006
20
Recurrent bilateral exophthalmos associated with metastatic thymic carcinoma in a pet rabbit. (16119059)
2005
21
Thymic carcinoma: a clinicopathological and immunohistological study of 19 cases. (15049903)
2004
22
Efficacy of docetaxel as a second-line chemotherapy for thymic carcinoma. (15608443)
2004
23
Thymic carcinoma presenting as cardiac tamponade. (14982285)
2004
24
Thymic carcinoma. Clinical institutional experience with 15 patients. (15296905)
2004
25
Thymic neuroendocrine carcinoma (carcinoid): what if octreotide scanning is negative? (15514629)
2004
26
Case of thymic parathyroid carcinoma in a haemodialysis patient: application of tumour chemosensitivity testing. (14979960)
2004
27
Unusual presentation of thymic carcinoma: hypertrophic osteoarthropathy. (12872453)
2003
28
Thymic carcinoma presenting as an intraluminal growth into the great vessels and the cardiac cavity. (12472400)
2002
29
Chemotherapy for advanced thymic carcinoma: clinical response to cisplatin, doxorubicin, vincristine, and cyclophosphamide (ADOC chemotherapy). (12040285)
2002
30
Thymic carcinoma with brain metastasis mimicking meningioma. (12187955)
2002
31
Thymic hyperplasia and lung carcinomas in a line of mice transgenic for keratin 5-driven HPV16 E6/E7 oncogenes. (11781829)
2001
32
A novel t(1;8)(p13;p11) in a thymic carcinoma with unusual giant cell features and renal metastasis. (11172906)
2001
33
Metastatic thymic carcinoma in a digit: a case report. (11119681)
2000
34
Frequent presence of neuroendocrine small cells in thymic carcinoma: a light microscopic and immunohistochemical study. (10931214)
2000
35
Thymic carcinoma. Outcome of treatment including surgical resection. (11002578)
2000
36
Thymoma and thymic carcinoma. (10366159)
1999
37
Spindle cell thymic carcinoma: clinicopathologic and immunohistochemical study of a distinctive variant of primary thymic epithelial neoplasm. (10366152)
1999
38
Thymoma, atypical thymoma, and thymic carcinoma. A novel conceptual approach to the classification of thymic epithelial neoplasms. (10361520)
1999
39
Neuroendocrine differentiation in thymic epithelial tumors with special reference to thymic carcinoma and atypical thymoma. (9563781)
1998
40
Immunohistochemical staining for bcl-2 and mcl-1 in intrathyroidal epithelial thymoma (ITET)/carcinoma showing thymus-like differentiation (CASTLE) and cervical thymic carcinoma. (9796728)
1998
41
Thymic carcinoma arising in thymoma is associated with alterations in immunohistochemical profile. (9850173)
1998
42
High frequency of p53 protein expression in thymic carcinoma but not in thymoma. (9374384)
1997
43
Thymic carcinoma which developed in a thymic cyst. (8785457)
1996
44
Thymic neuroendocrine carcinoma (carcinoid): a clinicopathologic study of fourteen cases. (8551758)
1996
45
Thymic carcinoma of the thyroid. (8869997)
1996
46
Malignant fibrous histiocytoma of the trachea combined with thymic carcinoma--a case report. (8313212)
1993
47
Thymic carcinoma associated with pinealoma and terminating with peroxidase-negative acute myeloid leukemia. (1392188)
1992
48
CT findings in primary thymic carcinoma. (2026804)
1991
49
Thymic carcinoma: clinical findings in two patients with extrathoracic metastases. (3368819)
1988
50
Thymic carcinoma with focal neuroblastoma differentiation. (3592061)
1987

Genetic Variations for Thymic Carcinoma

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Expression for genes affiliated with Thymic Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thymic Carcinoma

Search GEO for disease gene expression data for Thymic Carcinoma.

Pathways for genes affiliated with Thymic Carcinoma

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29KEGG, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Thymic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1KIT, DNTT, CD5
210.0NGFR, NKX2-1, SYP, NTRK1
310.0KRT19, KRT18, KRT7

Compounds for genes affiliated with Thymic Carcinoma

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44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Thymic Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8CALB2
2butyrate4410.6DNTT, CALB2
3glutamate4410.5NGFR, NTRK1
4reticulin4410.5SYP, MUC1, KRT7
5cyanine4410.4CEACAM3, CALB2
6glycogen44 2411.4SYP, KIT, KRT18, KRT7
7dexamethasone44 49 28 1113.3ALPP, NKX2-1, NME1, KRT18
8dutp4410.3KRT18, SYP, DNTT, NTRK1
9bdnf (human)5910.3NGFR, NTRK1
10gold4410.3CEACAM3, KRT18, KIT, MUC1, SYP
11p0034410.2NTRK1, KRT19, TP63, KIT
12serine4410.2NKX2-1, NME1, SYP, KRT19, ALPP
13p0024410.2NME1, KIT, KRT18, KRT19
145fluorouracil4410.2NME1, KRT18, KIT, CEACAM3, MUC1
15fitc4410.2KRT18, KRT19, DNTT
16ribonucleic acid4410.1KIT, NKX2-1, NME1, KRT19, MUC1
17ethanol44 49 11 2413.1CALB2, MUC1, NGFR, KRT18, SYP
18methotrexate44 49 1112.1CEACAM3, KIT, DNTT, MUC1, KRT7
19choline44 11 2412.1ALPP, NGFR, DNTT, NTRK1, SYP, CALB2
20acetylcholine44 49 28 11 2414.1NGFR, SYP, S100A1, CALB2, NTRK1
21dmso4410.0DNTT, MUC1, NME1, ALPP, TP63, KRT18
22retinoid4410.0NTRK1, NGFR, ALPP, KRT7, KRT18, KRT19
23formaldehyde44 2411.0KRT19, NKX2-1, SYP, KRT18, KRT7, MUC1
24bromodeoxyuridine4410.0TP63, KRT19, KRT18, DNTT
25creatinine4410.0KRT18, NME1, SYP, NTRK1, KRT19, CEACAM3
26indium449.9CEACAM3, MUC1
27mucicarmine449.9CALB2, S100A1, SYP, MUC1, KRT7, CEACAM3
28steroid449.9KRT18, KRT19, NME1, NGFR, SYP, NKX2-1
29hyaluronic acid44 2410.9MUC1, CALB2, MSLN, KRT19
30matrigel449.9KRT19, NME1, KRT18, TP63, MUC1, KRT7
31cisplatin44 49 59 1112.9NME1, TP63, ALPP, KRT19, MUC1, DNTT
32zinc44 2410.9NGFR, NKX2-1, KRT18, S100A1, CALB2, DNTT
33cysteine449.8SYP, NTRK1, NGFR, NME1, S100A1, KIT
34forskolin44 49 1111.8MUC1, NKX2-1, NGFR, SYP, KRT18
35oligonucleotide449.8NTRK1, DNTT, NGFR, NME1, KIT, KRT18
36glucose449.8MUC1, KRT18, KRT7, CEACAM3, NGFR, KRT19
37lactate449.8CEACAM3, NTRK1, DNTT, NME1, KIT, KRT19
38aspartate449.8NTRK1, CEACAM3, ALPP, KRT19, KIT, NME1
39cholesterol44 28 11 2412.8MUC1, NGFR, DNTT, CEACAM3, SYP, ALPP
40testosterone44 59 11 2412.6TP63, CALB2, SYP, KRT7, NTRK1, MUC1
41nitric oxide44 11 2411.5CALB2, SYP, NTRK1, DNTT, NGFR, MUC1
42thymidine44 2410.4DNTT, CEACAM3, KRT18, KRT19, KIT, NME1
43b 723449.4TP63, MUC1, SYP, NKX2-1, S100A1, CALB2
44hematoxylin449.4KIT, KRT18, KRT7, CEACAM3, TP63, KRT19
45calcium44 49 11 2412.3NGFR, MUC1, NME1, NTRK1, SYP, S100A1
46vegf449.2NTRK1, NGFR, MUC1, KIT, KRT18, SYP
47progesterone44 59 28 11 2413.2NTRK1, SYP, NKX2-1, S100A1, CALB2, NGFR
48retinoic acid44 2410.1MUC1, NGFR, DNTT, NTRK1, SYP, NKX2-1
49tyrosine449.1TP63, NTRK1, NGFR, MUC1, CD5, NME1
50paraffin448.7S100A1, NKX2-1, SYP, NTRK1, DNTT, NGFR

GO Terms for genes affiliated with Thymic Carcinoma

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16Gene Ontology
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Cellular components related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.0KRT7, KRT18, KRT19
2cell surfaceGO:0099869.5ALPP, MSLN, MUC1, NGFR, NTRK1

Biological processes related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2TP63, MUC1

Molecular functions related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nerve growth factor bindingGO:04840610.3NGFR, NTRK1
2protein bindingGO:0055158.4TP63, S100A1, NKX2-1, NTRK1, NGFR, MUC1

Products for genes affiliated with Thymic Carcinoma

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Sources for Thymic Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet