MCID: THY022
MIFTS: 56

Thymic Carcinoma malady

Cancer diseases, Rare diseases categories

Summaries for Thymic Carcinoma

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Disease Ontology:10 A thymus cancer that derives from epithelial cells. the tumor cells in a thymic carcinoma look very different from the normal cells of the thymus, grow more quickly, and have usually spread to other parts of the body when the cancer is found.

MalaCards based summary: Thymic Carcinoma, also known as malignant thymoma, is related to thymoma and adenocarcinoma, and has symptoms including neoplasm of the thymus, mediastinal lymphadenopathy and respiratory insufficiency. An important gene associated with Thymic Carcinoma is CD5 (CD5 molecule), and among its related pathways are Hematopoietic cell lineage and Neuroscience. The compounds s 100 and reticulin have been mentioned in the context of this disorder. Affiliated tissues include thymus, lung and brain, and related mouse phenotypes are no phenotypic analysis and digestive/alimentary.

Wikipedia:65 Thymic carcinoma is a rare type of thymus gland cancer. It usually spreads, has a high risk of... more...

Aliases & Classifications for Thymic Carcinoma

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Thymic Carcinoma, Aliases & Descriptions:

Name: Thymic Carcinoma 10 12 45 49 62
Malignant Thymoma 10 49 62
 
Thymoma, Malignant 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 49 
Rare tumors


Characteristics (Orphanet epidemiological data):

49
thymic carcinoma:
Inheritance: Not applicable; Age of onset: Adult; Age of death: any age


External Ids:

Disease Ontology10 DOID:3284
NCIt40 C7612
MeSH35 D013945
SNOMED-CT57 15949004, 128717008
Orphanet49 99868
ICD10 via Orphanet28 C37
UMLS via Orphanet63 C0205969, C1322286

Related Diseases for Thymic Carcinoma

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Diseases related to Thymic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.4CD5, NGFR, NKX2-1
2adenocarcinoma30.1MUC1, NGFR, KRT18, SYP, NKX2-1
3mesothelioma30.0NKX2-1, MUC1
4adenoma30.0KRT18, MUC1, SYP, NKX2-1
5lung cancer30.0SYP, KRT18, NKX2-1
6papillary carcinoma30.0NKX2-1, SYP, KRT18, MUC1
7lymphoepithelioma-like thymic carcinoma10.4
8thymic epithelial tumor10.3
9chronic mucocutaneous candidiasis10.3
10candidiasis10.3
11myocarditis10.3
12myasthenia gravis10.3
13cardiac tamponade10.3
14cushing's syndrome10.3
15dermatomyositis10.3
16mediastinitis10.3
17thyroiditis10.3
18polymyositis10.3
19intestinal pseudo-obstruction10.2
20giant cell myocarditis10.2
21limbic encephalitis10.2
22aplastic anemia10.2
23hepatitis10.2
24leukemia10.2
25cortical thymoma10.2
26adenoiditis10.2
27cervicitis10.2
28paraneoplastic syndromes10.2
29glomus tumor10.1SYP
30pulmonary blastoma10.1NKX2-1
31perineurioma10.0MUC1
32hemangioma10.0NKX2-1
33epidermodysplasia verruciformis10.0
34keratitis10.0
35coronary artery disease10.0
36good syndrome10.0
37malignant type a thymoma10.0
38malignant type ab thymoma10.0
39nocardiosis10.0
40ectopic thymus10.0
41primary hyperparathyroidism10.0
42artery disease10.0
43hyperparathyroidism10.0
44parathyroid adenoma10.0
45lambert syndrome10.0
46steroid-resistant nephrotic syndrome10.0
47dysautonomia10.0
48cardiogenic shock10.0
49merkel cell carcinoma10.0NKX2-1, SYP
50choroid plexus papilloma10.0SYP, MUC1

Graphical network of the top 20 diseases related to Thymic Carcinoma:



Diseases related to thymic carcinoma

Symptoms for Thymic Carcinoma

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Symptoms:

 49 (show all 13)
  • mediastinal/hilar adenopathies
  • thymus/thymic neoplasm/tumor/carcinoma/cancer/thymoma
  • palpebral edema/periorbital edema
  • cutaneous edema
  • diaphragmatic palsy
  • thoracic/chest pain
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • hyperhidrosis/increased sweating
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • myasthenia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • asthenia/fatigue/weakness

HPO human phenotypes related to Thymic Carcinoma:

(show all 10)
id Description Frequency HPO Source Accession
1 neoplasm of the thymus hallmark (90%) HP:0100521
2 mediastinal lymphadenopathy hallmark (90%) HP:0100721
3 respiratory insufficiency typical (50%) HP:0002093
4 diaphragmatic paralysis typical (50%) HP:0006597
5 periorbital edema typical (50%) HP:0100539
6 chest pain typical (50%) HP:0100749
7 hyperhidrosis occasional (7.5%) HP:0000975
8 weight loss occasional (7.5%) HP:0001824
9 abnormality of the pleura occasional (7.5%) HP:0002103
10 fatigable weakness occasional (7.5%) HP:0003473

Drugs & Therapeutics for Thymic Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Thymic Carcinoma

Search NIH Clinical Center for Thymic Carcinoma

Genetic Tests for Thymic Carcinoma

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Anatomical Context for Thymic Carcinoma

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MalaCards organs/tissues related to Thymic Carcinoma:

33
Thymus, Lung, Brain, Thyroid, Breast, Pituitary, Bone, Lymph node, Heart, Kidney, Pancreas, Testes, Myeloid, Monocytes, Trachea

Animal Models for Thymic Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Thymic Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1CD5, KIT, NKX2-1, SYP, MUC1
2MP:00053818.1KIT, NKX2-1, MUC1, NGFR
3MP:00053707.7NGFR, MUC1, KIT, KRT18
4MP:00028737.6NGFR, MUC1, SYP, KIT, CD5

Publications for Thymic Carcinoma

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Articles related to Thymic Carcinoma:

(show top 50)    (show all 348)
idTitleAuthorsYear
1
Immunohistochemical status of PD-L1 in thymoma and thymic carcinoma. (25799277)
2015
2
Rarest of a rare disease: challenges in advancing our knowledge of thymic carcinoma. (25524680)
2015
3
Long-term outcomes of surgery for thymic carcinoma: experience of 25 cases at a single institution. (25629460)
2015
4
Long-term follow-up and prognostic factors for advanced thymic carcinoma. (25526488)
2014
5
Massively parallel sequencing identifies recurrent mutations in TP53 in thymic carcinoma associated with poor prognosis. (25299233)
2014
6
Multimodality treatment for advanced thymic carcinoma: outcomes of induction therapy followed by surgical resection in 16 cases at a single institution. (25311849)
2014
7
Pure white cell aplasia in a patient with thymic carcinoma. (24137702)
2013
8
Successful chemotherapy with Carboplatin and s-1 for thymic carcinoma: a case report. (24348388)
2013
9
Early-stage thymic carcinoma: is adjuvant therapy required? (23585943)
2013
10
Long lasting efficacy of sorafenib in a heavily pretreated patient with thymic carcinoma. (23090205)
2012
11
Thymoma and thymic carcinoma. (22237733)
2012
12
Immunohistochemical analysis of thymic carcinoma focusing on the possibility of molecular targeted and hormonal therapies. (23054618)
2012
13
Management and outcomes of relapse after treatment for thymoma and thymic carcinoma. (22115206)
2011
14
Large thymic carcinoma presenting with right ventricular failure: a case report. (21938989)
2011
15
Promising efficacy of sorafenib in a relapsed thymic carcinoma with C-KIT exon 11 deletion mutation. (20970876)
2011
16
Thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic study of 7 cases. (21677542)
2011
17
Metastatic skull base tumor from thymic carcinoma mimicking Tolosa-Hunt syndrome. (20587979)
2010
18
Imatinib mesylate in patients with WHO B3 thymomas and thymic carcinomas. (20197733)
2009
19
Cerebellar ataxia associated with neuroendocrine thymic carcinoma and GAD antibodies. (19448100)
2009
20
Endobronchial ultrasound appearance of pulmonary artery thrombus in a patient with thymic carcinoma. (17805065)
2007
21
A case of mixed connective tissue disease complicated with thymic carcinoma and Hashimoto's thyroiditis. (17278025)
2007
22
Thymic carcinoma. (17225487)
2007
23
COX-2 upregulation in thymomas and thymic carcinomas. (16823844)
2006
24
Cerebral involvement of metastatic thymic carcinoma. (16132513)
2005
25
Aberrant methylation: common in thymic carcinomas, rare in thymomas. (16273266)
2005
26
Cardiac tamponade as manifestation of advanced thymic carcinoma. (15761459)
2005
27
Ga-67 uptake in thymic carcinoma: utility of Ga-67 scintigraphy in patient management. (14734918)
2004
28
Multimodality therapy for thymic carcinoma (TCA): results of a 30-year single-institution experience. (14758136)
2004
29
Thymic carcinoma: state of the art review. (15183468)
2004
30
Concurrent chemoradiotherapy for unresectable thymic carcinoma. (15508874)
2004
31
Thymic carcinoma: a clinicopathological and immunohistological study of 19 cases. (15049903)
2004
32
Thymic carcinoma presenting as cranial metastasis with intradural and extracranial extension: case report. (14683559)
2004
33
Efficacy of docetaxel as a second-line chemotherapy for thymic carcinoma. (15608443)
2004
34
Acquired myasthenia gravis associated with a non-invasive thymic carcinoma in a dog. (15086092)
2003
35
Postoperative radiotherapy in thymic carcinoma: treatment results and prognostic factors. (11849804)
2002
36
Metastatic thymic carcinoma in a digit: a case report. (11119681)
2000
37
Platinum-based chemotherapy with or without thoracic radiation therapy in patients with unresectable thymic carcinoma. (11095135)
2000
38
Thymic carcinoma--analysis of nineteen clinicopathological studies. (11028718)
2000
39
Thymoma and thymic carcinoma. (10366159)
1999
40
Radiotherapy for invasive thymoma and thymic carcinoma. Clinicopathological review. (10392168)
1999
41
Parathyroid-hormone-related-protein-producing thymic carcinoma presenting as a giant extrathoracic mass. (9523373)
1998
42
Late onset immunodeficiency in a patient with recurrent thymic carcinoma and myasthenia gravis. (9619646)
1998
43
Effective treatment of thymic carcinoma with operation and combination chemotherapy against acute monocyte leukemia: case report and review of the literature. (9793029)
1998
44
Assessment of residual tumor viability in thymic carcinoma by sequential thallium-201 SPECT: comparison with CT and biopsy findings. (7931668)
1994
45
Thymic carcinoma associated with pinealoma and terminating with peroxidase-negative acute myeloid leukemia. (1392188)
1992
46
Relapsing thymic carcinoma during pregnancy. (1326220)
1992
47
Primary thymic carcinoma and its association with dermatomyositis and pure red cell aplasia. (1512098)
1992
48
Establishment and characterization of a thymic carcinoma cell line (Ty-82) carrying t(15;19)(q15;p13) chromosome abnormality. (1730520)
1992
49
Thymic carcinoma. A clinicopathologic study of 13 cases. (1689123)
1990
50
Successful treatment of metastatic thymic carcinoma with cisplatin, vinblastine, bleomycin, and etoposide chemotherapy. (1699650)
1990

Variations for Thymic Carcinoma

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Cosmic variations for Thymic Carcinoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1133763KITthymus,NS,thymic carcinoma,undifferentiated carcinoma3

Expression for genes affiliated with Thymic Carcinoma

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Search GEO for disease gene expression data for Thymic Carcinoma.

Pathways for genes affiliated with Thymic Carcinoma

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Pathways related to Thymic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CD5, KIT
28.8NKX2-1, SYP, NGFR
3
Show member pathways
8.0KRT18, KIT, MUC1, NGFR

Compounds for genes affiliated with Thymic Carcinoma

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Compounds related to Thymic Carcinoma according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1s 100459.9MUC1, SYP
2reticulin459.9SYP, MUC1
3dutp459.8KRT18, SYP
4lithium45 51 26 1312.7SYP, MUC1
5methylcellulose459.6KRT18, KIT
6trastuzumab45 51 1311.5KIT, MUC1
7mucicarmine459.5NKX2-1, SYP, MUC1
8b 723459.5NKX2-1, SYP, MUC1
9chloroquine45 3 51 30 1313.5SYP, KIT
10ganglioside459.4NGFR, SYP
11dbc-amp459.4SYP, NGFR
12cytarabine45 51 1311.3KIT, MUC1
13creatinine459.3KRT18, SYP, MUC1
14ribonucleic acid459.2MUC1, NKX2-1, KIT
155fluorouracil459.2MUC1, KIT, KRT18
16catecholamine459.1NGFR, SYP
17actinomycin d459.1MUC1, KIT, KRT18
18p002459.0KRT18, KIT
19dopamine45 30 26 1312.0NGFR, SYP, KRT18
20agar459.0KRT18, MUC1, NGFR
21matrigel459.0NGFR, MUC1, KRT18
22phosphotyrosine459.0NGFR, SYP, KIT
23histamine45 30 2610.9KIT, SYP, NGFR
24leucine458.8NGFR, SYP, KIT
25gold458.8MUC1, SYP, KIT, KRT18
26glycogen45 269.8MUC1, SYP, KIT, KRT18
27testosterone45 61 26 1311.8KRT18, KIT, SYP, MUC1
28cholesterol45 30 26 1311.7SYP, MUC1, NGFR
29cyclic amp45 269.7NKX2-1, SYP, MUC1, NGFR
30ethanol45 51 26 1311.6KRT18, SYP, MUC1, NGFR
31lipid458.5NGFR, MUC1, SYP, KRT18
32oligonucleotide458.4NGFR, NKX2-1, KIT, KRT18
33cysteine458.4KIT, SYP, MUC1, NGFR
34formaldehyde45 269.4MUC1, SYP, NKX2-1, KIT, KRT18
35thymidine45 269.4NGFR, MUC1, KIT, KRT18
36glucose458.3NGFR, MUC1, KIT, KRT18
37forskolin45 51 1310.2NGFR, MUC1, SYP, NKX2-1, KRT18
38dexamethasone45 51 30 1311.2NGFR, MUC1, SYP, NKX2-1, KRT18
39steroid458.1NGFR, SYP, NKX2-1, KIT, KRT18
40calcium45 51 26 1311.1NGFR, MUC1, SYP, KIT, CD5
41vegf458.0KRT18, KIT, SYP, MUC1, NGFR
42nitric oxide45 26 1310.0NGFR, MUC1, SYP, KIT, KRT18
43threonine457.9NGFR, MUC1, NKX2-1, KIT, KRT18
44hematoxylin457.6KRT18, KIT, NKX2-1, SYP, MUC1, NGFR
45progesterone45 30 61 26 1311.6NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
46estrogen457.6NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
47retinoic acid45 268.6NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
48serine457.5NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
49paraffin457.2NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
50tyrosine457.2NGFR, MUC1, SYP, NKX2-1, KIT, KRT18

GO Terms for genes affiliated with Thymic Carcinoma

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Biological processes related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic signaling pathwayGO:00971909.3CD5, NGFR

Molecular functions related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00048889.3CD5, NGFR
2protein bindingGO:00055156.9CD5, KRT18, KIT, NKX2-1, MUC1, NGFR

Products for genes affiliated with Thymic Carcinoma

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Sources for Thymic Carcinoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet