MCID: THY022
MIFTS: 49

Thymic Carcinoma malady

Cancer diseases category
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Summaries for Thymic Carcinoma

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Disease Ontology:8 A thymus cancer that derives from epithelial cells. the tumor cells in a thymic carcinoma look very different from the normal cells of the thymus, grow more quickly, and have usually spread to other parts of the body when the cancer is found.

MalaCards based summary: Thymic Carcinoma, also known as malignant thymoma, is related to thymoma and lung cancer. An important gene associated with Thymic Carcinoma is CD5 (CD5 molecule), and among its related pathways are Hematopoietic cell lineage and Neuroscience. The compounds s 100 and reticulin have been mentioned in the context of this disorder. Affiliated tissues include thymus, brain and lung, and related mouse phenotypes are no phenotypic analysis and digestive/alimentary.

Aliases & Classifications for Thymic Carcinoma

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Thymic Carcinoma, Aliases & Descriptions:

Name: Thymic Carcinoma 8 62
Malignant Thymoma 8 62
 
Thymoma, Malignant 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:3284
NCIt39 C7612
SNOMED-CT57 128717008, 15949004
MeSH34 D013945

Related Diseases for Thymic Carcinoma

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Diseases related to Thymic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 141)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.3CD5, NGFR, NKX2-1
2lung cancer30.0SYP, NKX2-1, KRT18
3adenoma29.8KRT18, MUC1, SYP, NKX2-1
4papillary carcinoma29.8NKX2-1, SYP, KRT18, MUC1
5adenocarcinoma29.2MUC1, NGFR, KRT18, SYP, NKX2-1
6thymus cancer29.1KRT18, NKX2-1, KIT, MUC1, CD5, NGFR
7pulmonary blastoma10.5NKX2-1
8perineurioma10.4MUC1
9hemangioma10.4NKX2-1
10lymphoepithelioma-like thymic carcinoma10.4
11candidiasis10.3
12merkel cell carcinoma10.3NKX2-1, SYP
13chronic mucocutaneous candidiasis10.3
14myocarditis10.3
15choroid plexus papilloma10.3SYP, MUC1
16myasthenia gravis10.3
17cardiac tamponade10.3
18cushing's syndrome10.3
19dermatomyositis10.3
20mediastinitis10.3
21thyroiditis10.3
22polymyositis10.3
23thymic epithelial tumor10.3
24sertoli cell tumor10.2SYP, MUC1
25rhabdoid tumor10.2SYP, MUC1
26large cell carcinoma10.2NKX2-1, SYP
27hemangioblastoma10.2MUC1, SYP
28tubular adenocarcinoma10.2MUC1, SYP
29papillary adenocarcinoma10.2NKX2-1, MUC1
30sex cord-gonadal stromal tumor10.2NKX2-1, MUC1
31adenosquamous carcinoma10.2NKX2-1, MUC1
32abrikosov's tumor10.2NKX2-1, MUC1
33malignant pleural mesothelioma10.2NKX2-1, MUC1
34chordoma10.2KRT18, MUC1
35intestinal pseudo-obstruction10.2
36giant cell myocarditis10.2
37limbic encephalitis10.2
38angiosarcoma10.2KRT18, MUC1
39aplastic anemia10.2
40hepatitis10.2
41leukemia10.2
42cortical thymoma10.2
43adenoiditis10.2
44cervicitis10.2
45paraneoplastic syndromes10.2
46pleomorphic adenoma10.2MUC1, KRT18
47dermatofibrosarcoma protuberans10.2MUC1, KIT
48neuroendocrine tumor10.2NKX2-1, SYP
49malignant mixed mullerian tumor10.1KIT, MUC1
50paraganglioma10.1KIT, SYP

Graphical network of the top 20 diseases related to Thymic Carcinoma:



Diseases related to thymic carcinoma

Symptoms for Thymic Carcinoma

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Drugs & Therapeutics for Thymic Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Thymic Carcinoma

Search NIH Clinical Center for Thymic Carcinoma

Genetic Tests for Thymic Carcinoma

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Anatomical Context for Thymic Carcinoma

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MalaCards organs/tissues related to Thymic Carcinoma:

32
Thymus, Brain, Lung, Thyroid, Breast, Pituitary, Bone, Lymph node, Heart, Kidney, Pancreas, Testes, Myeloid, Monocytes, Trachea

Animal Models for Thymic Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Thymic Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1CD5, KIT, NKX2-1, SYP, MUC1
2MP:00053818.1KIT, NKX2-1, MUC1, NGFR
3MP:00053707.7NGFR, MUC1, KIT, KRT18
4MP:00028737.6NGFR, MUC1, SYP, KIT, CD5

Publications for Thymic Carcinoma

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Articles related to Thymic Carcinoma:

(show top 50)    (show all 325)
idTitleAuthorsYear
1
Massively parallel sequencing identifies recurrent mutations in TP53 in thymic carcinoma associated with poor prognosis. (25299233)
2014
2
Multimodality treatment for advanced thymic carcinoma: outcomes of induction therapy followed by surgical resection in 16 cases at a single institution. (25311849)
2014
3
Pure white cell aplasia in a patient with thymic carcinoma. (24137702)
2013
4
Successful chemotherapy with Carboplatin and s-1 for thymic carcinoma: a case report. (24348388)
2013
5
Stiff man syndrome with invasive thymic carcinoma. (23432176)
2013
6
Early-stage thymic carcinoma: is adjuvant therapy required? (23585943)
2013
7
Long lasting efficacy of sorafenib in a heavily pretreated patient with thymic carcinoma. (23090205)
2012
8
Thymoma and thymic carcinoma. (22237733)
2012
9
Immunohistochemical analysis of thymic carcinoma focusing on the possibility of molecular targeted and hormonal therapies. (23054618)
2012
10
Management and outcomes of relapse after treatment for thymoma and thymic carcinoma. (22115206)
2011
11
Large thymic carcinoma presenting with right ventricular failure: a case report. (21938989)
2011
12
Promising efficacy of sorafenib in a relapsed thymic carcinoma with C-KIT exon 11 deletion mutation. (20970876)
2011
13
Thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic study of 7 cases. (21677542)
2011
14
Metastatic skull base tumor from thymic carcinoma mimicking Tolosa-Hunt syndrome. (20587979)
2010
15
Imatinib mesylate in patients with WHO B3 thymomas and thymic carcinomas. (20197733)
2009
16
Cerebellar ataxia associated with neuroendocrine thymic carcinoma and GAD antibodies. (19448100)
2009
17
Thymic carcinoma: current concepts and histologic features. (18514123)
2008
18
Endobronchial ultrasound appearance of pulmonary artery thrombus in a patient with thymic carcinoma. (17805065)
2007
19
A case of mixed connective tissue disease complicated with thymic carcinoma and Hashimoto's thyroiditis. (17278025)
2007
20
Thymic carcinoma. (17225487)
2007
21
COX-2 upregulation in thymomas and thymic carcinomas. (16823844)
2006
22
Cerebral involvement of metastatic thymic carcinoma. (16132513)
2005
23
Aberrant methylation: common in thymic carcinomas, rare in thymomas. (16273266)
2005
24
Cardiac tamponade as manifestation of advanced thymic carcinoma. (15761459)
2005
25
Ga-67 uptake in thymic carcinoma: utility of Ga-67 scintigraphy in patient management. (14734918)
2004
26
Multimodality therapy for thymic carcinoma (TCA): results of a 30-year single-institution experience. (14758136)
2004
27
Thymic carcinoma: state of the art review. (15183468)
2004
28
Concurrent chemoradiotherapy for unresectable thymic carcinoma. (15508874)
2004
29
Thymic carcinoma: a clinicopathological and immunohistological study of 19 cases. (15049903)
2004
30
Thymic carcinoma presenting as cranial metastasis with intradural and extracranial extension: case report. (14683559)
2004
31
Efficacy of docetaxel as a second-line chemotherapy for thymic carcinoma. (15608443)
2004
32
Acquired myasthenia gravis associated with a non-invasive thymic carcinoma in a dog. (15086092)
2003
33
Postoperative radiotherapy in thymic carcinoma: treatment results and prognostic factors. (11849804)
2002
34
Metastatic thymic carcinoma in a digit: a case report. (11119681)
2000
35
Platinum-based chemotherapy with or without thoracic radiation therapy in patients with unresectable thymic carcinoma. (11095135)
2000
36
Thymic carcinoma--analysis of nineteen clinicopathological studies. (11028718)
2000
37
Thymoma and thymic carcinoma. (10366159)
1999
38
Radiotherapy for invasive thymoma and thymic carcinoma. Clinicopathological review. (10392168)
1999
39
Parathyroid-hormone-related-protein-producing thymic carcinoma presenting as a giant extrathoracic mass. (9523373)
1998
40
Late onset immunodeficiency in a patient with recurrent thymic carcinoma and myasthenia gravis. (9619646)
1998
41
Effective treatment of thymic carcinoma with operation and combination chemotherapy against acute monocyte leukemia: case report and review of the literature. (9793029)
1998
42
High frequency of p53 protein expression in thymic carcinoma but not in thymoma. (9374384)
1997
43
Assessment of residual tumor viability in thymic carcinoma by sequential thallium-201 SPECT: comparison with CT and biopsy findings. (7931668)
1994
44
Thymic carcinoma associated with pinealoma and terminating with peroxidase-negative acute myeloid leukemia. (1392188)
1992
45
Relapsing thymic carcinoma during pregnancy. (1326220)
1992
46
Primary thymic carcinoma and its association with dermatomyositis and pure red cell aplasia. (1512098)
1992
47
Establishment and characterization of a thymic carcinoma cell line (Ty-82) carrying t(15;19)(q15;p13) chromosome abnormality. (1730520)
1992
48
Thymic carcinoma. A clinicopathologic study of 13 cases. (1689123)
1990
49
Successful treatment of metastatic thymic carcinoma with cisplatin, vinblastine, bleomycin, and etoposide chemotherapy. (1699650)
1990
50
Histochemical and immunohistochemical evidence of glandular differentiation in thymic carcinoma. (2477989)
1989

Variations for Thymic Carcinoma

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Expression for genes affiliated with Thymic Carcinoma

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Expression patterns in normal tissues for genes affiliated with Thymic Carcinoma

Search GEO for disease gene expression data for Thymic Carcinoma.

Pathways for genes affiliated with Thymic Carcinoma

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Pathways related to Thymic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CD5, KIT
28.8NKX2-1, SYP, NGFR
3
Show member pathways
8.0KRT18, KIT, MUC1, NGFR

Compounds for genes affiliated with Thymic Carcinoma

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Compounds related to Thymic Carcinoma according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1s 100449.9MUC1, SYP
2reticulin449.9SYP, MUC1
3dutp449.8KRT18, SYP
4lithium44 50 24 1112.7SYP, MUC1
5methylcellulose449.6KRT18, KIT
6trastuzumab44 50 1111.5KIT, MUC1
7mucicarmine449.5NKX2-1, SYP, MUC1
8b 723449.5NKX2-1, SYP, MUC1
9chloroquine44 2 50 28 1113.5SYP, KIT
10ganglioside449.4NGFR, SYP
11dbc-amp449.4SYP, NGFR
12cytarabine44 50 1111.3KIT, MUC1
13creatinine449.3KRT18, SYP, MUC1
14ribonucleic acid449.2MUC1, NKX2-1, KIT
155fluorouracil449.2MUC1, KIT, KRT18
16catecholamine449.1NGFR, SYP
17actinomycin d449.1MUC1, KIT, KRT18
18p002449.0KRT18, KIT
19dopamine44 28 24 1112.0NGFR, SYP, KRT18
20agar449.0KRT18, MUC1, NGFR
21matrigel449.0NGFR, MUC1, KRT18
22phosphotyrosine449.0NGFR, SYP, KIT
23histamine44 28 2410.9KIT, SYP, NGFR
24leucine448.8NGFR, SYP, KIT
25gold448.8MUC1, SYP, KIT, KRT18
26glycogen44 249.8MUC1, SYP, KIT, KRT18
27testosterone44 61 24 1111.8KRT18, KIT, SYP, MUC1
28cholesterol44 28 24 1111.7SYP, MUC1, NGFR
29cyclic amp44 249.7NKX2-1, SYP, MUC1, NGFR
30ethanol44 50 24 1111.6KRT18, SYP, MUC1, NGFR
31lipid448.5NGFR, MUC1, SYP, KRT18
32oligonucleotide448.4NGFR, NKX2-1, KIT, KRT18
33cysteine448.4KIT, SYP, MUC1, NGFR
34formaldehyde44 249.4MUC1, SYP, NKX2-1, KIT, KRT18
35thymidine44 249.4NGFR, MUC1, KIT, KRT18
36glucose448.3NGFR, MUC1, KIT, KRT18
37forskolin44 50 1110.2NGFR, MUC1, SYP, NKX2-1, KRT18
38dexamethasone44 50 28 1111.2NGFR, MUC1, SYP, NKX2-1, KRT18
39steroid448.1NGFR, SYP, NKX2-1, KIT, KRT18
40calcium44 50 24 1111.1NGFR, MUC1, SYP, KIT, CD5
41vegf448.0KRT18, KIT, SYP, MUC1, NGFR
42nitric oxide44 24 1110.0NGFR, MUC1, SYP, KIT, KRT18
43threonine447.9NGFR, MUC1, NKX2-1, KIT, KRT18
44hematoxylin447.6KRT18, KIT, NKX2-1, SYP, MUC1, NGFR
45progesterone44 28 61 24 1111.6NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
46estrogen447.6NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
47retinoic acid44 248.6NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
48serine447.5NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
49paraffin447.2NGFR, MUC1, SYP, NKX2-1, KIT, KRT18
50tyrosine447.2NGFR, MUC1, SYP, NKX2-1, KIT, KRT18

GO Terms for genes affiliated with Thymic Carcinoma

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Biological processes related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic signaling pathwayGO:0971909.3CD5, NGFR

Molecular functions related to Thymic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.3CD5, NGFR
2protein bindingGO:0055156.9CD5, KRT18, KIT, NKX2-1, MUC1, NGFR

Products for genes affiliated with Thymic Carcinoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Thymic Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet