MCID: THY042
MIFTS: 34

Thymic Epithelial Tumor malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Thymic Epithelial Tumor

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Thymic Epithelial Tumor, Aliases & Descriptions:

Name: Thymic Epithelial Tumor 41 60
Epithelial Tumor of Thymus 41
 
Thymoma, Adult 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Summaries for Thymic Epithelial Tumor

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MalaCards based summary: Thymic Epithelial Tumor, also known as epithelial tumor of thymus, is related to thymoma and thymic carcinoma. An important gene associated with Thymic Epithelial Tumor is CD5 (CD5 molecule), and among its related pathways are p75(NTR)-mediated signaling and NGF Pathway. The compounds ganglioside and dbc-amp have been mentioned in the context of this disorder. Affiliated tissues include thymus, breast and heart, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Related Diseases for Thymic Epithelial Tumor

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Diseases related to Thymic Epithelial Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.1CD5, NGFR
2thymic carcinoma30.2NGFR, CD5, SYP, KIT
3breast cancer29.7MMP7, ERCC1, NGFR, NRAS, KIT
4glomus tumor10.4SYP
5myasthenia gravis10.3
6cortical thymoma10.2
7thymoma type a10.2
8thymoma type b10.2
9thymoma type ab10.2
10neuroblastoma10.2NGFR, SYP
11uveal melanoma10.1NGFR, NRAS
12ganglioneuroma10.1NGFR, SYP
13hirschsprung disease 110.1SYP, NGFR
14ependymoma10.1SYP, NGFR
15malignant mixed mullerian tumor10.1MMP7, KIT
16cholangiocarcinoma10.1NRAS, MMP7
17malignant peripheral nerve sheath tumor10.1KIT, NGFR
18neurofibromatosis10.0NGFR, KIT
19adenomatous polyposis coli10.0MMP7, NRAS
20merkel cell carcinoma10.0SYP, KIT
21neurilemmoma10.0NGFR, KIT
22ovarian cancer, somatic10.0MMP7, NGFR, ERCC1
23oxyphilic adenoma10.0SYP, KIT
24paraganglioma9.9SYP, KIT
25malignant glioma9.9ERCC1, SYP, NGFR
26pancreatic cancer9.9NRAS, NGFR, MMP7
27astrocytoma9.9SYP, ERCC1, NGFR
28gastric cancer, somatic9.9MMP7, ERCC1, NGFR
29myelodysplastic syndrome9.9NRAS, KIT
30sarcoma9.8KIT, NRAS, MMP7
31lung cancer9.8MMP7, SYP, ERCC1
32neuroendocrine tumor9.8MMP7, SYP, KIT
33glioblastoma9.8KIT, MMP7, NGFR
34neurofibroma9.8NGFR, SYP, KIT
35brain cancer9.8ERCC1, SYP, MMP7, NGFR
36tongue squamous cell carcinoma9.8NGFR, MMP7, SYP, ERCC1
37adenocarcinoma9.7NGFR, MMP7, ERCC1, SYP
38adenoma9.7SYP, MMP7, ERCC1, NRAS
39colorectal cancer9.7NRAS, MMP7, ERCC1
40leukemia9.7CD5, KIT, NRAS, NGFR
41melanoma9.6ERCC1, NRAS, KIT, NGFR
42small cell cancer of the lung, somatic9.6NGFR, ERCC1, KIT, SYP

Graphical network of the top 20 diseases related to Thymic Epithelial Tumor:



Diseases related to thymic epithelial tumor

Symptoms for Thymic Epithelial Tumor

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Drugs & Therapeutics for Thymic Epithelial Tumor

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Drug clinical trials:

Search ClinicalTrials for Thymic Epithelial Tumor

Search NIH Clinical Center for Thymic Epithelial Tumor

Genetic Tests for Thymic Epithelial Tumor

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Anatomical Context for Thymic Epithelial Tumor

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MalaCards organs/tissues related to Thymic Epithelial Tumor:

31
Thymus, Breast, Heart

Animal Models for Thymic Epithelial Tumor or affiliated genes

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MGI Mouse Phenotypes related to Thymic Epithelial Tumor:

35 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4NGFR, MMP7, NRAS, KIT
2MP:00020068.4ERCC1, KIT, NRAS, MMP7
3MP:00053918.4NGFR, MMP7, NRAS, KIT
4MP:00053708.4NGFR, NRAS, KIT, ERCC1
5MP:00030128.3CD5, KIT, NRAS, SYP
6MP:00053858.3KIT, NRAS, MMP7, NGFR
7MP:00107718.2NGFR, NRAS, KIT, ERCC1
8MP:00028737.9NGFR, SYP, NRAS, KIT, CD5
9MP:00053847.9ERCC1, KIT, NRAS, MMP7, NGFR
10MP:00053787.8ERCC1, KIT, NRAS, MMP7, NGFR
11MP:00053977.7CD5, ERCC1, KIT, NRAS, MMP7, NGFR
12MP:00053767.6ERCC1, KIT, NRAS, MMP7, NGFR
13MP:00053877.6NGFR, MMP7, NRAS, KIT, ERCC1, CD5
14MP:00107687.4NGFR, MMP7, NRAS, KIT, ERCC1

Publications for Thymic Epithelial Tumor

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Articles related to Thymic Epithelial Tumor:

(show all 46)
idTitleAuthorsYear
1
Postoperative radiotherapy is effective for thymic carcinoma but not for thymoma in stage II and III thymic epithelial tumors: The Japanese Association for Research on the Thymus Database Study. (25565590)
2015
2
The presence of extrathoracic metastasis is more prognostic of survival than Masaoka stage (IVa/IVb) in metastatic thymic epithelial tumor: a retrospective cohort study. (24954359)
2014
3
Tumor-to-tumor metastasis: breast cancer metastatic to thymic epithelial tumor. (23695010)
2013
4
STAT3 expression correlates with prognosis of thymic epithelial tumors. (23590999)
2013
5
Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors. (23444221)
2013
6
NUT rearrangement is uncommon in human thymic epithelial tumors. (22425924)
2012
7
Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systems. (22974165)
2012
8
Is There a Role of Postoperative Radiation Therapy in Completely Resected Stage I/II Thymic Epithelial Tumor? (23091442)
2012
9
Expression of excision repair cross-complementation group 1, breast cancer susceptibility 1, and I^ III-tubulin in thymic epithelial tumors. (21289518)
2011
10
MUC1 expression in thymic epithelial tumors: MUC1 may be useful marker as differential diagnosis between type B3 thymoma and thymic carcinoma. (21253760)
2011
11
Expression of proteasome subunit I^5t in thymic epithelial tumors. (21836487)
2011
12
Successful diagnosis of a combined thymic epithelial tumor by endobronchial ultrasound-guided transbronchial needle aspiration. (23896935)
2011
13
Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors. (21372220)
2011
14
Expression and mutational status of c-kit in thymic epithelial tumors. (20651610)
2010
15
Thymic epithelial tumor with heart metastasis in a horse. (20814442)
2010
16
CD98 expression is associated with the grade of malignancy in thymic epithelial tumors. (20811665)
2010
17
Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report. (19901887)
2009
18
Computed tomographic findings and prognosis in thymic epithelial tumor patients. (18830115)
2008
19
Absence of gene mutations in KIT-positive thymic epithelial tumors. (18486988)
2008
20
Adjuvant radiotherapy for thymic epithelial tumor: treatment results and prognostic factors. (17762439)
2007
21
Correlation between MMP-2 activation and MT1-MMP mRNA expression in thymic epithelial tumors]. (16608644)
2006
22
Expression and mutation statuses of epidermal growth factor receptor in thymic epithelial tumors. (16762968)
2006
23
Multimodality treatment program in invasive thymic epithelial tumor. (15685027)
2005
24
Expression of neurotrophin receptors in surgically resected thymic epithelial tumors. (16125946)
2005
25
Immunohistochemical KIT (CD117) expression in thymic epithelial tumors. (16002927)
2005
26
Expression of cyclins D1, D3 and p27 in thymic epithelial tumors. (17670226)
2004
27
High incidence of thymic epithelial tumors in E2F2 transgenic mice. (14684733)
2004
28
KI-67 antigen expression predicts survival and correlates with histologic subtype in the WHO classification of thymic epithelial tumors. (15494865)
2004
29
Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors. (14584061)
2003
30
Expression of matrix metalloproteinases 2 and 7 in tumor cells correlates with the World Health Organization classification subtype and clinical stage of thymic epithelial tumors. (14691910)
2003
31
Apoptosis in thymic epithelial tumors. (12234065)
2002
32
Thymic epithelial tumors can develop along two different pathogenetic pathways. (11696445)
2001
33
Activation of matrix metalloproteinase-2 is correlated with invasiveness in thymic epithelial tumors. (11276020)
2001
34
Differential expression of NGF receptors in human thymic epithelial tumors. (10483585)
1999
35
Correlation between clinical aggressiveness of thymic epithelial tumors and expression of tumor suppressor gene products (p53, p27)]. (10496046)
1999
36
Neuroendocrine differentiation in thymic epithelial tumors with special reference to thymic carcinoma and atypical thymoma. (9563781)
1998
37
Thymic epithelial tumor progression in an SV40T transgenic mouse model. Cortical thymoma-thymic carcinoma sequence. (9463585)
1998
38
p53 alteration, proliferating cell nuclear antigen, and nucleolar organizer regions in thymic epithelial tumors. (9852302)
1998
39
Apoptosis, bcl-2 protein, and Fas antigen in thymic epithelial tumors. (9346177)
1997
40
Paraneoplastic myasthenia gravis: detection of anti-MGT30 (titin) antibodies predicts thymic epithelial tumor. (9371941)
1997
41
Cell kinetic study of thymic epithelial tumors using PCNA (PC10) and Ki-67 (MIB-1) antibodies. (8543314)
1996
42
p53 protein expression and p53 mutation in thymic epithelial tumors. (8623777)
1996
43
Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. Implications for the pathogenesis of myasthenia gravis. (8669470)
1996
44
The MIC2 antibody 013. Practical application for the study of thymic epithelial tumors. (7573670)
1995
45
p53 protein expression and p53 gene mutation in thymic epithelial tumors. An immunohistochemical and DNA sequencing study. (7572785)
1995
46
Cytokeratins in normal thymus and thymic epithelial tumors. (7677978)
1993

Variations for Thymic Epithelial Tumor

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Expression for genes affiliated with Thymic Epithelial Tumor

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Search GEO for disease gene expression data for Thymic Epithelial Tumor.

Pathways for genes affiliated with Thymic Epithelial Tumor

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Pathways related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6MMP7, NGFR
2
Show member pathways
9.5NRAS, NGFR
39.3CD5, KIT
4
Show member pathways
9.1KIT, NRAS
5
Show member pathways
Signal transduction PTEN pathway58
9.1KIT, NRAS
69.1NRAS, KIT
7
Show member pathways
8.7NGFR, NRAS, KIT
8
Show member pathways
8.7NGFR, NRAS, KIT
9
Show member pathways
8.7NGFR, NRAS, KIT
10
Show member pathways
8.7KIT, NRAS, NGFR
11
Show member pathways
8.7KIT, NRAS, NGFR
12
Show member pathways
8.7KIT, NRAS, NGFR
13
Show member pathways
8.7NGFR, NRAS, KIT
14
Show member pathways
8.7NGFR, NRAS, KIT
15
Show member pathways
8.7NGFR, NRAS, KIT
16
Show member pathways
8.7KIT, NRAS, NGFR
178.7NGFR, NRAS, KIT
18
Show member pathways
8.7KIT, NRAS, NGFR
19
Show member pathways
8.3KIT, NRAS, MMP7, NGFR

Compounds for genes affiliated with Thymic Epithelial Tumor

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Compounds related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

(show all 27)
idCompoundScoreTop Affiliating Genes
1ganglioside439.6SYP, NGFR
2dbc-amp439.6NGFR, SYP
3catecholamine439.4SYP, NGFR
4irinotecan43 49 1211.3ERCC1, KIT
5p002439.2KIT, MMP7
6chloroquine43 2 49 28 1213.1KIT, SYP
7lead439.0ERCC1, KIT
8doxorubicin43 49 1211.0MMP7, KIT, ERCC1
9hematoxylin438.9KIT, SYP, NGFR
10thymidine43 249.9ERCC1, KIT, NGFR
11phosphotyrosine438.9NGFR, SYP, KIT
12histamine43 28 2410.8KIT, SYP, NGFR
13vincristine43 49 1210.8ERCC1, KIT
14steroid438.6NGFR, SYP, KIT
15phosphatidylinositol438.6NGFR, MMP7, KIT, ERCC1
16leucine438.5NGFR, MMP7, SYP, KIT
17progesterone43 28 59 24 1212.5NGFR, MMP7, SYP, KIT
18nitric oxide43 24 1210.5KIT, SYP, MMP7, NGFR
19retinoic acid43 249.5KIT, SYP, MMP7, NGFR
20cysteine438.4NGFR, MMP7, SYP, KIT
21serine438.4NGFR, MMP7, SYP, KIT
22paraffin438.2NGFR, MMP7, SYP, KIT, CD5
23oligonucleotide438.1NGFR, MMP7, NRAS, KIT, ERCC1
24calcium43 49 24 1211.1NGFR, MMP7, SYP, KIT, CD5
25vegf438.0ERCC1, KIT, SYP, MMP7, NGFR
26estrogen438.0NGFR, MMP7, SYP, KIT, ERCC1
27tyrosine437.1CD5, ERCC1, KIT, NRAS, SYP, MMP7

GO Terms for genes affiliated with Thymic Epithelial Tumor

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Biological processes related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apoptotic signaling pathwayGO:00971909.6CD5, NGFR
2regulation of long-term neuronal synaptic plasticityGO:00481699.4NRAS, SYP
3visual learningGO:00085429.1NRAS, KIT
4male gonad developmentGO:00085849.0ERCC1, KIT
5regulation of cell proliferationGO:00421278.9KIT, MMP7
6neurotrophin TRK receptor signaling pathwayGO:00480118.7KIT, NRAS, NGFR

Molecular functions related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00048889.6CD5, NGFR

Products for genes affiliated with Thymic Epithelial Tumor

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Thymic Epithelial Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet