MCID: THY042
MIFTS: 28

Thymic Epithelial Tumor

Categories: Rare diseases

Aliases & Classifications for Thymic Epithelial Tumor

MalaCards integrated aliases for Thymic Epithelial Tumor:

Name: Thymic Epithelial Tumor 49 69
Epithelial Tumor of Thymus 49
Thymoma, Adult 49

Classifications:



External Ids:

UMLS 69 C1266101

Summaries for Thymic Epithelial Tumor

MalaCards based summary : Thymic Epithelial Tumor, also known as epithelial tumor of thymus, is related to thymoma and thymoma, familial. An important gene associated with Thymic Epithelial Tumor is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drugs Cisplatin and Pembrolizumab have been mentioned in the context of this disorder. Affiliated tissues include thymus, lung and heart, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Thymic Epithelial Tumor

Diseases related to Thymic Epithelial Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 thymoma 29.4 CD5 KIT
2 thymoma, familial 11.5
3 thymoma type a 11.1
4 thymoma type b 11.1
5 thymoma type ab 11.1
6 pulmonary vein stenosis 9.9 CD99 KIT
7 blood group, i system 9.9
8 myasthenia gravis 9.9
9 myasthenia gravis congenital 9.9
10 thymic hyperplasia 9.9
11 malignant skin fibrous histiocytoma 9.9 CD99 KIT
12 malignant dermis tumor 9.9 CD99 KIT
13 connective tissue cancer 9.8 CD99 KIT
14 teratoma 9.8 CD99 KIT
15 epidural neoplasm 9.8 CD5 CD99
16 glomerulonephritis 9.7
17 conn's syndrome 9.7
18 cortical thymoma 9.7
19 mixed type thymoma 9.7 CD5 KIT
20 mediastinal cancer 9.7 CD5 KIT
21 necrotizing sialometaplasia 9.7 CD5 KIT
22 thymus cancer 9.6 CD5 KIT
23 ewing sarcoma 9.5 CD99 KIT
24 leukemia, acute myeloid 9.4 CD5 KIT

Graphical network of the top 20 diseases related to Thymic Epithelial Tumor:



Diseases related to Thymic Epithelial Tumor

Symptoms & Phenotypes for Thymic Epithelial Tumor

GenomeRNAi Phenotypes related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.28 CD99
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.28 KIT
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.28 KIT
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.28 CD99
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.28 CD99
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.28 CD99
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.28 CD99 KIT
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.28 CD99

Drugs & Therapeutics for Thymic Epithelial Tumor

Drugs for Thymic Epithelial Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
2
Pembrolizumab Approved Phase 2 1374853-91-4
3
Palbociclib Approved, Investigational Phase 2 571190-30-2 5330286 11431660 5005498
4
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
5
Docetaxel Approved May 1996, Investigational Phase 2 114977-28-5 148124 9877265
6 Antimitotic Agents Phase 2
7 Protein Kinase Inhibitors Phase 2
8 Albumin-Bound Paclitaxel Phase 2
9 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neoadjuvant Chemotherapy for Locally Advanced Thymic Cancer Completed NCT01312324 Phase 2 neoadjuvant docetaxel/cisplatin
2 Trial of Sunitinib in Patients With Type B3 Thymoma or Thymic Carcinoma in Second and Further Lines (Style Trial) Recruiting NCT03449173 Phase 2 Sunitinib
3 A Study of Pembrolizumab for Patients With Thymic Epithelial Tumor Not yet recruiting NCT02607631 Phase 2 Pembrolizumab
4 Selinexor in Patients With Advanced Thymic Epithelial Tumor Progressing After Primary Chemotherapy Not yet recruiting NCT03193437 Phase 2 Open Label Selinexor
5 A Phase II Study of Palbociclib for Recurrent or Refractory Advanced Thymic Epithelial Tumor Not yet recruiting NCT03219554 Phase 2 Palbociclib
6 Paclitaxel and Cisplatin for Thymic Neoplasm Terminated NCT00818090 Phase 2 paclitaxel and cisplatin
7 Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors Completed NCT03288662
8 French National Observatory of Patients With Thymic Epithelial Tumor Recruiting NCT02724696
9 Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors Recruiting NCT02146170
10 Preoperative Prediction of of Thymic Epithelial Tumors by Diffusion-Weighted MR Imaging Not yet recruiting NCT03212027

Search NIH Clinical Center for Thymic Epithelial Tumor

Genetic Tests for Thymic Epithelial Tumor

Anatomical Context for Thymic Epithelial Tumor

MalaCards organs/tissues related to Thymic Epithelial Tumor:

38
Thymus, Lung, Heart

Publications for Thymic Epithelial Tumor

Articles related to Thymic Epithelial Tumor:

(show top 50) (show all 65)
# Title Authors Year
1
Comparison of Interobserver Agreement and Diagnostic Accuracy for IASLC/ITMIG Thymic Epithelial Tumor Staging Among Co-registered FDG-PET/MRI, Whole-body MRI, Integrated FDG-PET/CT, and Conventional Imaging Examination with and without Contrast Media Administrations. ( 29395795 )
2018
2
GTF2I Mutations Are Common in Thymic Epithelial Tumors But Not in Hematological Malignancies. ( 28982856 )
2017
3
Antineutrophil Cytoplasmic Antibody-Associated Rapid Progressive Glomerulonephritis after Pembrolizumab Treatment in Thymic Epithelial Tumor: A Case Report. ( 28342816 )
2017
4
Expression of cathepsins V and S in thymic epithelial tumors. ( 27771373 )
2017
5
Circulating miR-21-5p and miR-148a-3p as emerging non-invasive biomarkers in thymic epithelial tumors. ( 26575977 )
2016
6
Thymic Epithelial Tumor-Associated Cytopenia: A 10-Year Observational Study in France. ( 26768832 )
2016
7
Expression of programmed death 1 (PD-1) and its ligand (PD-L1) in thymic epithelial tumors: Impact on treatment efficacy and alteration in expression after chemotherapy. ( 27565906 )
2016
8
Thymic Hyperplasia After Treatment of ACTH-Dependent Cushing's Syndrome Can Be Mistaken for a Thymic Epithelial Tumor. ( 27865872 )
2016
9
Differentiating the grades of thymic epithelial tumor malignancy using textural features of intratumoral heterogeneity via (18)F-FDG PET/CT. ( 26868139 )
2016
10
Occasional detection of thymic epithelial tumor 4 years after diagnosis of adult onset Still disease: A challenging case report and immuno-oncological considerations coming from pertinent literature review. ( 27603335 )
2016
11
Value of volume-based early metabolic response in patients with unresectable thymic epithelial tumor. ( 27597277 )
2016
12
Postoperative radiotherapy is effective for thymic carcinoma but not for thymoma in stage II and III thymic epithelial tumors: The Japanese Association for Research on the Thymus Database Study. ( 25565590 )
2015
13
Expression of pRb and p16INK4 in human thymic epithelial tumors in relation to the presence of human polyomavirus 7. ( 26537237 )
2015
14
Erratum: Omasa M, Date H, Sozu T, Sato T, Nagai K, Yokoi K, Okamoto T, Ikeda N, Tanaka F, and Maniwa Y, and the Japanese Association for Research on the Thymus. Postoperative radiotherapy is effective for thymic carcinoma but not for thymoma in stage II and III thymic epithelial tumors: The Japanese Association for Research on the Thymus Database Study. Cancer. doi: 10.1002/cncr.29166. ( 26057775 )
2015
15
Perplexing histologic classification of thymic epithelial tumor. ( 25997137 )
2015
16
Diffuse high intensity PD-L1 staining in thymic epithelial tumors. ( 25402569 )
2015
17
Methylation and expression profiles of MGMT gene in thymic epithelial tumors. ( 24388682 )
2014
18
A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors. ( 24974848 )
2014
19
Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology. ( 24705787 )
2014
20
Difference in distribution profiles between CD163+ tumor-associated macrophages and S100+ dendritic cells in thymic epithelial tumors. ( 25499804 )
2014
21
The presence of extrathoracic metastasis is more prognostic of survival than Masaoka stage (IVa/IVb) in metastatic thymic epithelial tumor: a retrospective cohort study. ( 24954359 )
2014
22
Tumor-to-tumor metastasis: breast cancer metastatic to thymic epithelial tumor. ( 23695010 )
2013
23
Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors. ( 23444221 )
2013
24
STAT3 expression correlates with prognosis of thymic epithelial tumors. ( 23590999 )
2013
25
Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systems. ( 22974165 )
2012
26
Is There a Role of Postoperative Radiation Therapy in Completely Resected Stage I/II Thymic Epithelial Tumor? ( 23091442 )
2012
27
NUT rearrangement is uncommon in human thymic epithelial tumors. ( 22425924 )
2012
28
Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors. ( 21372220 )
2011
29
Expression of excision repair cross-complementation group 1, breast cancer susceptibility 1, and I^ III-tubulin in thymic epithelial tumors. ( 21289518 )
2011
30
MUC1 expression in thymic epithelial tumors: MUC1 may be useful marker as differential diagnosis between type B3 thymoma and thymic carcinoma. ( 21253760 )
2011
31
Expression of proteasome subunit I^5t in thymic epithelial tumors. ( 21836487 )
2011
32
Successful diagnosis of a combined thymic epithelial tumor by endobronchial ultrasound-guided transbronchial needle aspiration. ( 23896935 )
2011
33
CD98 expression is associated with the grade of malignancy in thymic epithelial tumors. ( 20811665 )
2010
34
Expression and mutational status of c-kit in thymic epithelial tumors. ( 20651610 )
2010
35
Thymic epithelial tumor with heart metastasis in a horse. ( 20814442 )
2010
36
Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report. ( 19901887 )
2009
37
Computed tomographic findings and prognosis in thymic epithelial tumor patients. ( 18830115 )
2008
38
Absence of gene mutations in KIT-positive thymic epithelial tumors. ( 18486988 )
2008
39
Adjuvant radiotherapy for thymic epithelial tumor: treatment results and prognostic factors. ( 17762439 )
2007
40
Expression and mutation statuses of epidermal growth factor receptor in thymic epithelial tumors. ( 16762968 )
2006
41
[Correlation between MMP-2 activation and MT1-MMP mRNA expression in thymic epithelial tumors]. ( 16608644 )
2006
42
Multimodality treatment program in invasive thymic epithelial tumor. ( 15685027 )
2005
43
Expression of neurotrophin receptors in surgically resected thymic epithelial tumors. ( 16125946 )
2005
44
Immunohistochemical KIT (CD117) expression in thymic epithelial tumors. ( 16002927 )
2005
45
Expression of cyclins D1, D3 and p27 in thymic epithelial tumors. ( 17670226 )
2004
46
KI-67 antigen expression predicts survival and correlates with histologic subtype in the WHO classification of thymic epithelial tumors. ( 15494865 )
2004
47
High incidence of thymic epithelial tumors in E2F2 transgenic mice. ( 14684733 )
2004
48
Expression of matrix metalloproteinases 2 and 7 in tumor cells correlates with the World Health Organization classification subtype and clinical stage of thymic epithelial tumors. ( 14691910 )
2003
49
Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors. ( 14584061 )
2003
50
Apoptosis in thymic epithelial tumors. ( 12234065 )
2002

Variations for Thymic Epithelial Tumor

Expression for Thymic Epithelial Tumor

Search GEO for disease gene expression data for Thymic Epithelial Tumor.

Pathways for Thymic Epithelial Tumor

Pathways related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.22 CD5 KIT
2 10.94 CD5 KIT
3 10.35 CD5 KIT

GO Terms for Thymic Epithelial Tumor

Cellular components related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 CD5 KIT

Sources for Thymic Epithelial Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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