MCID: THY042
MIFTS: 39

Thymic Epithelial Tumor malady

Rare diseases, Cancer diseases categories

Summaries for Thymic Epithelial Tumor

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MalaCards based summary: Thymic Epithelial Tumor, also known as epithelial tumor of thymus, is related to thymoma and thymic carcinoma. An important gene associated with Thymic Epithelial Tumor is CD5 (CD5 molecule), and among its related pathways are p75(NTR)-mediated signaling and NGF Pathway. The compounds ganglioside and dbc-amp have been mentioned in the context of this disorder. Affiliated tissues include thymus, breast and heart, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Thymic Epithelial Tumor

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Thymic Epithelial Tumor, Aliases & Descriptions:

Name: Thymic Epithelial Tumor 43 62
Epithelial Tumor of Thymus 43 62
 
Thymoma, Adult 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Thymic Epithelial Tumor

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Diseases related to Thymic Epithelial Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma30.8NGFR, CD5
2thymic carcinoma30.6CD5, KIT, SYP, NGFR
3breast cancer30.4NGFR, MMP7, NRAS, KIT, ERCC1
4myasthenia gravis10.3
5cortical thymoma10.2
6thymoma type a10.2
7thymoma type b10.2
8thymoma type ab10.2
9glomus tumor10.0SYP
10neuroblastoma10.0SYP, NGFR
11uveal melanoma10.0NGFR, NRAS
12ganglioneuroma10.0NGFR, SYP
13hirschsprung disease 110.0NGFR, SYP
14ependymoma10.0NGFR, SYP
15malignant mixed mullerian tumor10.0KIT, MMP7
16cholangiocarcinoma10.0MMP7, NRAS
17malignant peripheral nerve sheath tumor10.0KIT, NGFR
18neurofibromatosis10.0NGFR, KIT
19adenomatous polyposis coli10.0NRAS, MMP7
20merkel cell carcinoma10.0SYP, KIT
21neurilemmoma10.0KIT, NGFR
22ovarian cancer, somatic10.0NGFR, MMP7, ERCC1
23oxyphilic adenoma10.0KIT, SYP
24paraganglioma10.0SYP, KIT
25malignant glioma10.0ERCC1, SYP, NGFR
26pancreatic cancer10.0NGFR, MMP7, NRAS
27astrocytoma10.0ERCC1, SYP, NGFR
28gastric cancer, somatic10.0ERCC1, MMP7, NGFR
29myelodysplastic syndrome10.0KIT, NRAS
30sarcoma10.0MMP7, NRAS, KIT
31lung cancer10.0ERCC1, SYP, MMP7
32neuroendocrine tumor10.0KIT, SYP, MMP7
33glioblastoma10.0NGFR, MMP7, KIT
34neurofibroma10.0KIT, SYP, NGFR
35brain cancer10.0NGFR, MMP7, SYP, ERCC1
36tongue squamous cell carcinoma10.0NGFR, MMP7, SYP, ERCC1
37adenocarcinoma10.0NGFR, MMP7, SYP, ERCC1
38adenoma10.0MMP7, SYP, NRAS, ERCC1
39colorectal cancer10.0MMP7, NRAS, ERCC1
40leukemia10.0CD5, KIT, NRAS, NGFR
41melanoma9.9ERCC1, KIT, NRAS, NGFR
42small cell cancer of the lung, somatic9.9NGFR, SYP, KIT, ERCC1

Graphical network of the top 20 diseases related to Thymic Epithelial Tumor:



Diseases related to thymic epithelial tumor

Symptoms for Thymic Epithelial Tumor

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Drugs & Therapeutics for Thymic Epithelial Tumor

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Drug clinical trials:

Search ClinicalTrials for Thymic Epithelial Tumor

Search NIH Clinical Center for Thymic Epithelial Tumor

Genetic Tests for Thymic Epithelial Tumor

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Anatomical Context for Thymic Epithelial Tumor

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MalaCards organs/tissues related to Thymic Epithelial Tumor:

33
Thymus, Breast, Heart

Animal Models for Thymic Epithelial Tumor or affiliated genes

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MGI Mouse Phenotypes related to Thymic Epithelial Tumor:

37 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4NGFR, MMP7, NRAS, KIT
2MP:00020068.4ERCC1, KIT, NRAS, MMP7
3MP:00053918.4NGFR, MMP7, NRAS, KIT
4MP:00053708.4NGFR, NRAS, KIT, ERCC1
5MP:00030128.3CD5, KIT, NRAS, SYP
6MP:00053858.3KIT, NRAS, MMP7, NGFR
7MP:00107718.2NGFR, NRAS, KIT, ERCC1
8MP:00028737.9NGFR, SYP, NRAS, KIT, CD5
9MP:00053847.9ERCC1, KIT, NRAS, MMP7, NGFR
10MP:00053787.8ERCC1, KIT, NRAS, MMP7, NGFR
11MP:00053977.7CD5, ERCC1, KIT, NRAS, MMP7, NGFR
12MP:00053767.6ERCC1, KIT, NRAS, MMP7, NGFR
13MP:00053877.6NGFR, MMP7, NRAS, KIT, ERCC1, CD5
14MP:00107687.4NGFR, MMP7, NRAS, KIT, ERCC1

Publications for Thymic Epithelial Tumor

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Articles related to Thymic Epithelial Tumor:

(show all 46)
idTitleAuthorsYear
1
Postoperative radiotherapy is effective for thymic carcinoma but not for thymoma in stage II and III thymic epithelial tumors: The Japanese Association for Research on the Thymus Database Study. (25565590)
2015
2
The presence of extrathoracic metastasis is more prognostic of survival than Masaoka stage (IVa/IVb) in metastatic thymic epithelial tumor: a retrospective cohort study. (24954359)
2014
3
Tumor-to-tumor metastasis: breast cancer metastatic to thymic epithelial tumor. (23695010)
2013
4
STAT3 expression correlates with prognosis of thymic epithelial tumors. (23590999)
2013
5
Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors. (23444221)
2013
6
NUT rearrangement is uncommon in human thymic epithelial tumors. (22425924)
2012
7
Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systems. (22974165)
2012
8
Is There a Role of Postoperative Radiation Therapy in Completely Resected Stage I/II Thymic Epithelial Tumor? (23091442)
2012
9
Expression of excision repair cross-complementation group 1, breast cancer susceptibility 1, and I^ III-tubulin in thymic epithelial tumors. (21289518)
2011
10
MUC1 expression in thymic epithelial tumors: MUC1 may be useful marker as differential diagnosis between type B3 thymoma and thymic carcinoma. (21253760)
2011
11
Expression of proteasome subunit I^5t in thymic epithelial tumors. (21836487)
2011
12
Successful diagnosis of a combined thymic epithelial tumor by endobronchial ultrasound-guided transbronchial needle aspiration. (23896935)
2011
13
Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors. (21372220)
2011
14
Expression and mutational status of c-kit in thymic epithelial tumors. (20651610)
2010
15
Thymic epithelial tumor with heart metastasis in a horse. (20814442)
2010
16
CD98 expression is associated with the grade of malignancy in thymic epithelial tumors. (20811665)
2010
17
Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report. (19901887)
2009
18
Computed tomographic findings and prognosis in thymic epithelial tumor patients. (18830115)
2008
19
Absence of gene mutations in KIT-positive thymic epithelial tumors. (18486988)
2008
20
Adjuvant radiotherapy for thymic epithelial tumor: treatment results and prognostic factors. (17762439)
2007
21
Correlation between MMP-2 activation and MT1-MMP mRNA expression in thymic epithelial tumors]. (16608644)
2006
22
Expression and mutation statuses of epidermal growth factor receptor in thymic epithelial tumors. (16762968)
2006
23
Multimodality treatment program in invasive thymic epithelial tumor. (15685027)
2005
24
Expression of neurotrophin receptors in surgically resected thymic epithelial tumors. (16125946)
2005
25
Immunohistochemical KIT (CD117) expression in thymic epithelial tumors. (16002927)
2005
26
Expression of cyclins D1, D3 and p27 in thymic epithelial tumors. (17670226)
2004
27
High incidence of thymic epithelial tumors in E2F2 transgenic mice. (14684733)
2004
28
KI-67 antigen expression predicts survival and correlates with histologic subtype in the WHO classification of thymic epithelial tumors. (15494865)
2004
29
Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors. (14584061)
2003
30
Expression of matrix metalloproteinases 2 and 7 in tumor cells correlates with the World Health Organization classification subtype and clinical stage of thymic epithelial tumors. (14691910)
2003
31
Apoptosis in thymic epithelial tumors. (12234065)
2002
32
Thymic epithelial tumors can develop along two different pathogenetic pathways. (11696445)
2001
33
Activation of matrix metalloproteinase-2 is correlated with invasiveness in thymic epithelial tumors. (11276020)
2001
34
Differential expression of NGF receptors in human thymic epithelial tumors. (10483585)
1999
35
Correlation between clinical aggressiveness of thymic epithelial tumors and expression of tumor suppressor gene products (p53, p27)]. (10496046)
1999
36
Neuroendocrine differentiation in thymic epithelial tumors with special reference to thymic carcinoma and atypical thymoma. (9563781)
1998
37
Thymic epithelial tumor progression in an SV40T transgenic mouse model. Cortical thymoma-thymic carcinoma sequence. (9463585)
1998
38
p53 alteration, proliferating cell nuclear antigen, and nucleolar organizer regions in thymic epithelial tumors. (9852302)
1998
39
Apoptosis, bcl-2 protein, and Fas antigen in thymic epithelial tumors. (9346177)
1997
40
Paraneoplastic myasthenia gravis: detection of anti-MGT30 (titin) antibodies predicts thymic epithelial tumor. (9371941)
1997
41
Cell kinetic study of thymic epithelial tumors using PCNA (PC10) and Ki-67 (MIB-1) antibodies. (8543314)
1996
42
p53 protein expression and p53 mutation in thymic epithelial tumors. (8623777)
1996
43
Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. Implications for the pathogenesis of myasthenia gravis. (8669470)
1996
44
The MIC2 antibody 013. Practical application for the study of thymic epithelial tumors. (7573670)
1995
45
p53 protein expression and p53 gene mutation in thymic epithelial tumors. An immunohistochemical and DNA sequencing study. (7572785)
1995
46
Cytokeratins in normal thymus and thymic epithelial tumors. (7677978)
1993

Variations for Thymic Epithelial Tumor

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Expression for genes affiliated with Thymic Epithelial Tumor

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Search GEO for disease gene expression data for Thymic Epithelial Tumor.

Pathways for genes affiliated with Thymic Epithelial Tumor

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Pathways related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6MMP7, NGFR
2
Show member pathways
9.5NRAS, NGFR
39.3CD5, KIT
4
Show member pathways
9.1KIT, NRAS
5
Show member pathways
Signal transduction PTEN pathway60
9.1KIT, NRAS
69.1NRAS, KIT
7
Show member pathways
8.7NGFR, NRAS, KIT
8
Show member pathways
8.7NGFR, NRAS, KIT
9
Show member pathways
8.7NGFR, NRAS, KIT
10
Show member pathways
8.7KIT, NRAS, NGFR
11
Show member pathways
8.7KIT, NRAS, NGFR
12
Show member pathways
8.7KIT, NRAS, NGFR
13
Show member pathways
8.7NGFR, NRAS, KIT
14
Show member pathways
8.7NGFR, NRAS, KIT
15
Show member pathways
8.7NGFR, NRAS, KIT
16
Show member pathways
8.7KIT, NRAS, NGFR
178.7NGFR, NRAS, KIT
18
Show member pathways
8.7KIT, NRAS, NGFR
19
Show member pathways
8.3KIT, NRAS, MMP7, NGFR

Compounds for genes affiliated with Thymic Epithelial Tumor

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Compounds related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1ganglioside459.6SYP, NGFR
2dbc-amp459.6NGFR, SYP
3catecholamine459.4SYP, NGFR
4irinotecan45 51 1311.3ERCC1, KIT
5p002459.2KIT, MMP7
6chloroquine45 3 51 30 1313.1KIT, SYP
7lead459.0ERCC1, KIT
8doxorubicin45 51 1311.0MMP7, KIT, ERCC1
9hematoxylin458.9KIT, SYP, NGFR
10thymidine45 269.9ERCC1, KIT, NGFR
11phosphotyrosine458.9NGFR, SYP, KIT
12histamine45 30 2610.8KIT, SYP, NGFR
13vincristine45 51 1310.8ERCC1, KIT
14steroid458.6NGFR, SYP, KIT
15phosphatidylinositol458.6NGFR, MMP7, KIT, ERCC1
16leucine458.5NGFR, MMP7, SYP, KIT
17progesterone45 30 61 26 1312.5NGFR, MMP7, SYP, KIT
18nitric oxide45 26 1310.5KIT, SYP, MMP7, NGFR
19retinoic acid45 269.5KIT, SYP, MMP7, NGFR
20cysteine458.4NGFR, MMP7, SYP, KIT
21serine458.4NGFR, MMP7, SYP, KIT
22paraffin458.2NGFR, MMP7, SYP, KIT, CD5
23oligonucleotide458.1NGFR, MMP7, NRAS, KIT, ERCC1
24calcium45 51 26 1311.1NGFR, MMP7, SYP, KIT, CD5
25vegf458.0ERCC1, KIT, SYP, MMP7, NGFR
26estrogen458.0NGFR, MMP7, SYP, KIT, ERCC1
27tyrosine457.1CD5, ERCC1, KIT, NRAS, SYP, MMP7

GO Terms for genes affiliated with Thymic Epithelial Tumor

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Biological processes related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic signaling pathwayGO:00971909.6CD5, NGFR
2regulation of long-term neuronal synaptic plasticityGO:00481699.4NRAS, SYP
3visual learningGO:00085429.1NRAS, KIT
4male gonad developmentGO:00085849.0ERCC1, KIT
5regulation of cell proliferationGO:00421278.9KIT, MMP7
6neurotrophin TRK receptor signaling pathwayGO:00480118.7KIT, NRAS, NGFR

Molecular functions related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00048889.6CD5, NGFR

Products for genes affiliated with Thymic Epithelial Tumor

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Thymic Epithelial Tumor

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet