MCID: THY042
MIFTS: 40

Thymic Epithelial Tumor malady

Rare diseases, Cancer diseases categories
Download this MalaCard

Summaries for Thymic Epithelial Tumor

About this section


Fully expand this MalaCard
MalaCards based summary: Thymic Epithelial Tumor, also known as epithelial tumor of thymus, is related to thymoma and breast cancer. An important gene associated with Thymic Epithelial Tumor is CD5 (CD5 molecule), and among its related pathways are p75(NTR)-mediated signaling and NGF Pathway. The compounds ganglioside and dbc-amp have been mentioned in the context of this disorder. Affiliated tissues include thymus, breast and heart, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Thymic Epithelial Tumor

About this section

Thymic Epithelial Tumor, Aliases & Descriptions:

Name: Thymic Epithelial Tumor 42 62
Epithelial Tumor of Thymus 42 62
 
Thymoma, Adult 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Thymic Epithelial Tumor

About this section

Diseases related to Thymic Epithelial Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.0CD5, NGFR
2breast cancer29.7MMP7, ERCC1, NGFR, NRAS, KIT
3thymic carcinoma10.4
4myasthenia gravis10.3
5cortical thymoma10.2
6thymic hyperplasia10.2
7breast cancer susceptibility10.2
8thymoma type a10.2
9thymoma type b10.2
10thymoma type ab10.2
11neuroblastoma10.2NGFR, SYP
12uveal melanoma10.1NGFR, NRAS
13ganglioneuroma10.1NGFR, SYP
14hirschsprung's disease10.1SYP, NGFR
15ependymoma10.1SYP, NGFR
16malignant mixed mullerian tumor10.1MMP7, KIT
17cholangiocarcinoma10.1NRAS, MMP7
18malignant peripheral nerve sheath tumor10.1KIT, NGFR
19neurofibromatosis10.0NGFR, KIT
20familial adenomatous polyposis10.0MMP7, NRAS
21merkel cell carcinoma10.0SYP, KIT
22neurilemmoma10.0NGFR, KIT
23ovarian cancer10.0MMP7, NGFR, ERCC1
24oxyphilic adenoma10.0SYP, KIT
25paraganglioma9.9SYP, KIT
26malignant glioma9.9ERCC1, SYP, NGFR
27pancreatic cancer9.9NRAS, NGFR, MMP7
28astrocytoma9.9SYP, ERCC1, NGFR
29lung cancer9.9SYP, NRAS, ERCC1
30stomach cancer9.9MMP7, ERCC1, NGFR
31myelodysplastic syndromes9.9NRAS, KIT
32sarcoma9.9KIT, NRAS, MMP7
33non-small cell lung carcinoma9.9MMP7, SYP, ERCC1
34neuroendocrine carcinoma9.8MMP7, SYP, KIT
35glioblastoma9.8KIT, MMP7, NGFR
36neurofibroma9.8NGFR, SYP, KIT
37brain cancer9.8ERCC1, SYP, MMP7, NGFR
38tongue squamous cell carcinoma9.8NGFR, MMP7, SYP, ERCC1
39adenocarcinoma9.8NGFR, MMP7, ERCC1, SYP
40adenoma9.7SYP, MMP7, ERCC1, NRAS
41colorectal cancer9.7NRAS, MMP7, ERCC1
42thymus cancer9.7NGFR, CD5, SYP, KIT
43leukemia9.7CD5, KIT, NRAS, NGFR
44melanoma9.6ERCC1, NRAS, KIT, NGFR
45lung small cell carcinoma9.6NGFR, ERCC1, KIT, SYP

Graphical network of the top 20 diseases related to Thymic Epithelial Tumor:



Diseases related to thymic epithelial tumor

Symptoms for Thymic Epithelial Tumor

About this section

Drugs & Therapeutics for Thymic Epithelial Tumor

About this section

Drug clinical trials:

Search ClinicalTrials for Thymic Epithelial Tumor

Search NIH Clinical Center for Thymic Epithelial Tumor

Genetic Tests for Thymic Epithelial Tumor

About this section

Anatomical Context for Thymic Epithelial Tumor

About this section

MalaCards organs/tissues related to Thymic Epithelial Tumor:

32
Thymus, Breast, Heart

Animal Models for Thymic Epithelial Tumor or affiliated genes

About this section

MGI Mouse Phenotypes related to Thymic Epithelial Tumor:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4NGFR, MMP7, NRAS, KIT
2MP:00020068.4ERCC1, KIT, NRAS, MMP7
3MP:00053918.4NGFR, MMP7, NRAS, KIT
4MP:00053708.4NGFR, NRAS, KIT, ERCC1
5MP:00030128.3CD5, KIT, NRAS, SYP
6MP:00053858.3KIT, NRAS, MMP7, NGFR
7MP:00107718.2NGFR, NRAS, KIT, ERCC1
8MP:00028737.9NGFR, SYP, NRAS, KIT, CD5
9MP:00053847.9ERCC1, KIT, NRAS, MMP7, NGFR
10MP:00053787.8ERCC1, KIT, NRAS, MMP7, NGFR
11MP:00053977.7CD5, ERCC1, KIT, NRAS, MMP7, NGFR
12MP:00053767.6ERCC1, KIT, NRAS, MMP7, NGFR
13MP:00053877.6NGFR, MMP7, NRAS, KIT, ERCC1, CD5
14MP:00107687.4NGFR, MMP7, NRAS, KIT, ERCC1

Publications for Thymic Epithelial Tumor

About this section

Articles related to Thymic Epithelial Tumor:

(show all 46)
idTitleAuthorsYear
1
Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology. (24705787)
2014
2
The presence of extrathoracic metastasis is more prognostic of survival than Masaoka stage (IVa/IVb) in metastatic thymic epithelial tumor: a retrospective cohort study. (24954359)
2014
3
Tumor-to-tumor metastasis: breast cancer metastatic to thymic epithelial tumor. (23695010)
2013
4
STAT3 expression correlates with prognosis of thymic epithelial tumors. (23590999)
2013
5
Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors. (23444221)
2013
6
NUT rearrangement is uncommon in human thymic epithelial tumors. (22425924)
2012
7
Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systems. (22974165)
2012
8
Is There a Role of Postoperative Radiation Therapy in Completely Resected Stage I/II Thymic Epithelial Tumor? (23091442)
2012
9
Expression of excision repair cross-complementation group 1, breast cancer susceptibility 1, and I^ III-tubulin in thymic epithelial tumors. (21289518)
2011
10
MUC1 expression in thymic epithelial tumors: MUC1 may be useful marker as differential diagnosis between type B3 thymoma and thymic carcinoma. (21253760)
2011
11
Expression of proteasome subunit I^5t in thymic epithelial tumors. (21836487)
2011
12
Successful diagnosis of a combined thymic epithelial tumor by endobronchial ultrasound-guided transbronchial needle aspiration. (23896935)
2011
13
Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors. (21372220)
2011
14
Expression and mutational status of c-kit in thymic epithelial tumors. (20651610)
2010
15
Thymic epithelial tumor with heart metastasis in a horse. (20814442)
2010
16
CD98 expression is associated with the grade of malignancy in thymic epithelial tumors. (20811665)
2010
17
Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report. (19901887)
2009
18
Computed tomographic findings and prognosis in thymic epithelial tumor patients. (18830115)
2008
19
Absence of gene mutations in KIT-positive thymic epithelial tumors. (18486988)
2008
20
Adjuvant radiotherapy for thymic epithelial tumor: treatment results and prognostic factors. (17762439)
2007
21
Correlation between MMP-2 activation and MT1-MMP mRNA expression in thymic epithelial tumors]. (16608644)
2006
22
Expression and mutation statuses of epidermal growth factor receptor in thymic epithelial tumors. (16762968)
2006
23
Multimodality treatment program in invasive thymic epithelial tumor. (15685027)
2005
24
Expression of neurotrophin receptors in surgically resected thymic epithelial tumors. (16125946)
2005
25
Immunohistochemical KIT (CD117) expression in thymic epithelial tumors. (16002927)
2005
26
Expression of cyclins D1, D3 and p27 in thymic epithelial tumors. (17670226)
2004
27
High incidence of thymic epithelial tumors in E2F2 transgenic mice. (14684733)
2004
28
KI-67 antigen expression predicts survival and correlates with histologic subtype in the WHO classification of thymic epithelial tumors. (15494865)
2004
29
Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors. (14584061)
2003
30
Expression of matrix metalloproteinases 2 and 7 in tumor cells correlates with the World Health Organization classification subtype and clinical stage of thymic epithelial tumors. (14691910)
2003
31
Apoptosis in thymic epithelial tumors. (12234065)
2002
32
Thymic epithelial tumors can develop along two different pathogenetic pathways. (11696445)
2001
33
Activation of matrix metalloproteinase-2 is correlated with invasiveness in thymic epithelial tumors. (11276020)
2001
34
Differential expression of NGF receptors in human thymic epithelial tumors. (10483585)
1999
35
Correlation between clinical aggressiveness of thymic epithelial tumors and expression of tumor suppressor gene products (p53, p27)]. (10496046)
1999
36
Neuroendocrine differentiation in thymic epithelial tumors with special reference to thymic carcinoma and atypical thymoma. (9563781)
1998
37
Thymic epithelial tumor progression in an SV40T transgenic mouse model. Cortical thymoma-thymic carcinoma sequence. (9463585)
1998
38
p53 alteration, proliferating cell nuclear antigen, and nucleolar organizer regions in thymic epithelial tumors. (9852302)
1998
39
Apoptosis, bcl-2 protein, and Fas antigen in thymic epithelial tumors. (9346177)
1997
40
Paraneoplastic myasthenia gravis: detection of anti-MGT30 (titin) antibodies predicts thymic epithelial tumor. (9371941)
1997
41
Cell kinetic study of thymic epithelial tumors using PCNA (PC10) and Ki-67 (MIB-1) antibodies. (8543314)
1996
42
p53 protein expression and p53 mutation in thymic epithelial tumors. (8623777)
1996
43
Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. Implications for the pathogenesis of myasthenia gravis. (8669470)
1996
44
The MIC2 antibody 013. Practical application for the study of thymic epithelial tumors. (7573670)
1995
45
p53 protein expression and p53 gene mutation in thymic epithelial tumors. An immunohistochemical and DNA sequencing study. (7572785)
1995
46
Cytokeratins in normal thymus and thymic epithelial tumors. (7677978)
1993

Variations for Thymic Epithelial Tumor

About this section

Expression for genes affiliated with Thymic Epithelial Tumor

About this section
Expression patterns in normal tissues for genes affiliated with Thymic Epithelial Tumor

Search GEO for disease gene expression data for Thymic Epithelial Tumor.

Pathways for genes affiliated with Thymic Epithelial Tumor

About this section

Pathways related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6MMP7, NGFR
2
Show member pathways
9.5NRAS, NGFR
39.3CD5, KIT
4
Show member pathways
9.1KIT, NRAS
5
Show member pathways
Signal transduction PTEN pathway60
9.1KIT, NRAS
69.1NRAS, KIT
7
Show member pathways
8.7NGFR, NRAS, KIT
8
Show member pathways
8.7NGFR, NRAS, KIT
9
Show member pathways
8.7NGFR, NRAS, KIT
10
Show member pathways
8.7KIT, NRAS, NGFR
11
Show member pathways
8.7KIT, NRAS, NGFR
12
Show member pathways
8.7KIT, NRAS, NGFR
13
Show member pathways
8.7NGFR, NRAS, KIT
14
Show member pathways
8.7NGFR, NRAS, KIT
15
Show member pathways
8.7NGFR, NRAS, KIT
16
Show member pathways
8.7KIT, NRAS, NGFR
178.7NGFR, NRAS, KIT
18
Show member pathways
8.7KIT, NRAS, NGFR
19
Show member pathways
8.3KIT, NRAS, MMP7, NGFR

Compounds for genes affiliated with Thymic Epithelial Tumor

About this section

Compounds related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1ganglioside449.6SYP, NGFR
2dbc-amp449.6NGFR, SYP
3catecholamine449.4SYP, NGFR
4irinotecan44 50 1111.3ERCC1, KIT
5p002449.2KIT, MMP7
6chloroquine44 2 50 28 1113.1KIT, SYP
7lead449.0ERCC1, KIT
8doxorubicin44 50 1111.0MMP7, KIT, ERCC1
9hematoxylin448.9KIT, SYP, NGFR
10thymidine44 249.9ERCC1, KIT, NGFR
11phosphotyrosine448.9NGFR, SYP, KIT
12histamine44 28 2410.8KIT, SYP, NGFR
13vincristine44 50 1110.8ERCC1, KIT
14steroid448.6NGFR, SYP, KIT
15phosphatidylinositol448.6NGFR, MMP7, KIT, ERCC1
16leucine448.5NGFR, MMP7, SYP, KIT
17progesterone44 28 61 24 1112.5NGFR, MMP7, SYP, KIT
18nitric oxide44 24 1110.5KIT, SYP, MMP7, NGFR
19retinoic acid44 249.5KIT, SYP, MMP7, NGFR
20cysteine448.4NGFR, MMP7, SYP, KIT
21serine448.4NGFR, MMP7, SYP, KIT
22paraffin448.2NGFR, MMP7, SYP, KIT, CD5
23oligonucleotide448.1NGFR, MMP7, NRAS, KIT, ERCC1
24calcium44 50 24 1111.1NGFR, MMP7, SYP, KIT, CD5
25vegf448.0ERCC1, KIT, SYP, MMP7, NGFR
26estrogen448.0NGFR, MMP7, SYP, KIT, ERCC1
27tyrosine447.1CD5, ERCC1, KIT, NRAS, SYP, MMP7

GO Terms for genes affiliated with Thymic Epithelial Tumor

About this section

Biological processes related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic signaling pathwayGO:0971909.6CD5, NGFR
2regulation of long-term neuronal synaptic plasticityGO:0481699.4NRAS, SYP
3visual learningGO:0085429.1NRAS, KIT
4male gonad developmentGO:0085849.0ERCC1, KIT
5regulation of cell proliferationGO:0421278.9KIT, MMP7
6neurotrophin TRK receptor signaling pathwayGO:0480118.7KIT, NRAS, NGFR

Molecular functions related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.6CD5, NGFR

Products for genes affiliated with Thymic Epithelial Tumor

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Thymic Epithelial Tumor

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet