MCID: THY042
MIFTS: 39

Thymic Epithelial Tumor malady

Rare diseases, Cancer diseases categories

Summaries for Thymic Epithelial Tumor

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34MalaCards
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MalaCards: Thymic Epithelial Tumor, also known as epithelial tumor of thymus, is related to thymoma and breast cancer. An important gene associated with Thymic Epithelial Tumor is CD5 (CD5 molecule), and among its related pathways are p75(NTR)-mediated signaling and NGF Pathway. The compounds ganglioside and dbc-amp have been mentioned in the context of this disorder. Affiliated tissues include thymus, breast and heart, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Thymic Epithelial Tumor

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

thymic epithelial tumor 44 63
epithelial tumor of thymus 44
thymoma, adult 44


Related Diseases for Thymic Epithelial Tumor

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18GeneCards, 19GeneDecks
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Diseases related to Thymic Epithelial Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma30.8CD5, NGFR
2breast cancer30.3MMP7, ERCC1, NGFR, NRAS, KIT
3thymic carcinoma10.4
4myasthenia gravis10.3
5thymic epithelial neoplasm10.3
6cortical thymoma10.2
7breast cancer susceptibility10.2
8thymoma type a10.2
9thymoma type b10.2
10thymoma type ab10.2
11glomus tumor10.1SYP
12neuroblastoma10.0NGFR, SYP
13intraocular melanoma10.0NGFR, NRAS
14ganglioneuroma10.0NGFR, SYP
15hirschsprung's disease10.0SYP, NGFR
16ependymoma10.0SYP, NGFR
17malignant mixed mullerian tumor10.0MMP7, KIT
18cholangiocarcinoma10.0NRAS, MMP7
19malignant peripheral nerve sheath tumor10.0KIT, NGFR
20neurofibromatosis10.0NGFR, KIT
21familial adenomatous polyposis10.0MMP7, NRAS
22merkel cell carcinoma10.0SYP, KIT
23neurilemmoma10.0NGFR, KIT
24ovarian cancer10.0MMP7, NGFR, ERCC1
25oxyphilic adenoma10.0SYP, KIT
26paraganglioma10.0SYP, KIT
27malignant glioma10.0ERCC1, SYP, NGFR
28pancreatic cancer10.0NRAS, NGFR, MMP7
29astrocytoma10.0SYP, ERCC1, NGFR
30lung cancer10.0SYP, NRAS, ERCC1
31stomach cancer10.0MMP7, ERCC1, NGFR
32myelodysplastic syndromes10.0NRAS, KIT
33sarcoma10.0KIT, NRAS, MMP7
34non-small cell lung carcinoma10.0MMP7, SYP, ERCC1
35neuroendocrine carcinoma10.0MMP7, SYP, KIT
36glioblastoma multiforme10.0KIT, MMP7, NGFR
37neurofibroma10.0NGFR, SYP, KIT
38brain cancer9.9ERCC1, SYP, MMP7, NGFR
39tongue squamous cell carcinoma9.9NGFR, MMP7, SYP, ERCC1
40adenocarcinoma9.9NGFR, MMP7, ERCC1, SYP
41adenoma9.9SYP, MMP7, ERCC1, NRAS
42colorectal cancer9.9NRAS, MMP7, ERCC1
43thymus cancer9.9NGFR, CD5, SYP, KIT
44leukemia9.9CD5, KIT, NRAS, NGFR
45melanoma9.9ERCC1, NRAS, KIT, NGFR
46lung small cell carcinoma9.9NGFR, ERCC1, KIT, SYP

Graphical network of the top 20 diseases related to Thymic Epithelial Tumor:



Diseases related to thymic epithelial tumor

Symptoms for Thymic Epithelial Tumor

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Drugs & Therapeutics for Thymic Epithelial Tumor

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Thymic Epithelial Tumor

Drug clinical trials:

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Search NIH Clinical Center for Thymic Epithelial Tumor

Search CenterWatch for Thymic Epithelial Tumor

Genetic Tests for Thymic Epithelial Tumor

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Anatomical Context for Thymic Epithelial Tumor

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34MalaCards
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MalaCards organs/tissues related to Thymic Epithelial Tumor:

34
Thymus, Breast, Heart

Animal Models for Thymic Epithelial Tumor or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Thymic Epithelial Tumor:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4NGFR, MMP7, NRAS, KIT
2MP:00020068.4ERCC1, KIT, NRAS, MMP7
3MP:00053918.4NGFR, MMP7, NRAS, KIT
4MP:00053708.4NGFR, NRAS, KIT, ERCC1
5MP:00030128.3CD5, KIT, NRAS, SYP
6MP:00053858.3KIT, NRAS, MMP7, NGFR
7MP:00107718.2NGFR, NRAS, KIT, ERCC1
8MP:00028737.9NGFR, SYP, NRAS, KIT, CD5
9MP:00053847.9ERCC1, KIT, NRAS, MMP7, NGFR
10MP:00053787.8ERCC1, KIT, NRAS, MMP7, NGFR
11MP:00053977.7CD5, ERCC1, KIT, NRAS, MMP7, NGFR
12MP:00053767.6ERCC1, KIT, NRAS, MMP7, NGFR
13MP:00053877.6NGFR, MMP7, NRAS, KIT, ERCC1, CD5
14MP:00107687.4NGFR, MMP7, NRAS, KIT, ERCC1

Publications for Thymic Epithelial Tumor

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53PubMed
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Articles related to Thymic Epithelial Tumor:

(show all 41)
idTitleAuthorsYear
1
Tumor-to-tumor metastasis: breast cancer metastatic to thymic epithelial tumor. (23695010)
2013
2
NUT rearrangement is uncommon in human thymic epithelial tumors. (22425924)
2012
3
Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systems. (22974165)
2012
4
Is There a Role of Postoperative Radiation Therapy in Completely Resected Stage I/II Thymic Epithelial Tumor? (23091442)
2012
5
Expression of excision repair cross-complementation group 1, breast cancer susceptibility 1, and I^ III-tubulin in thymic epithelial tumors. (21289518)
2011
6
MUC1 expression in thymic epithelial tumors: MUC1 may be useful marker as differential diagnosis between type B3 thymoma and thymic carcinoma. (21253760)
2011
7
Expression of proteasome subunit I^5t in thymic epithelial tumors. (21836487)
2011
8
Successful diagnosis of a combined thymic epithelial tumor by endobronchial ultrasound-guided transbronchial needle aspiration. (23896935)
2011
9
Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors. (21372220)
2011
10
Expression and mutational status of c-kit in thymic epithelial tumors. (20651610)
2010
11
Thymic epithelial tumor with heart metastasis in a horse. (20814442)
2010
12
CD98 expression is associated with the grade of malignancy in thymic epithelial tumors. (20811665)
2010
13
Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report. (19901887)
2009
14
Computed tomographic findings and prognosis in thymic epithelial tumor patients. (18830115)
2008
15
Absence of gene mutations in KIT-positive thymic epithelial tumors. (18486988)
2008
16
Adjuvant radiotherapy for thymic epithelial tumor: treatment results and prognostic factors. (17762439)
2007
17
Correlation between MMP-2 activation and MT1-MMP mRNA expression in thymic epithelial tumors]. (16608644)
2006
18
Expression and mutation statuses of epidermal growth factor receptor in thymic epithelial tumors. (16762968)
2006
19
Multimodality treatment program in invasive thymic epithelial tumor. (15685027)
2005
20
Expression of neurotrophin receptors in surgically resected thymic epithelial tumors. (16125946)
2005
21
Immunohistochemical KIT (CD117) expression in thymic epithelial tumors. (16002927)
2005
22
Expression of cyclins D1, D3 and p27 in thymic epithelial tumors. (17670226)
2004
23
High incidence of thymic epithelial tumors in E2F2 transgenic mice. (14684733)
2004
24
KI-67 antigen expression predicts survival and correlates with histologic subtype in the WHO classification of thymic epithelial tumors. (15494865)
2004
25
Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors. (14584061)
2003
26
Expression of matrix metalloproteinases 2 and 7 in tumor cells correlates with the World Health Organization classification subtype and clinical stage of thymic epithelial tumors. (14691910)
2003
27
Apoptosis in thymic epithelial tumors. (12234065)
2002
28
Thymic epithelial tumors can develop along two different pathogenetic pathways. (11696445)
2001
29
Activation of matrix metalloproteinase-2 is correlated with invasiveness in thymic epithelial tumors. (11276020)
2001
30
Differential expression of NGF receptors in human thymic epithelial tumors. (10483585)
1999
31
Correlation between clinical aggressiveness of thymic epithelial tumors and expression of tumor suppressor gene products (p53, p27)]. (10496046)
1999
32
Neuroendocrine differentiation in thymic epithelial tumors with special reference to thymic carcinoma and atypical thymoma. (9563781)
1998
33
Thymic epithelial tumor progression in an SV40T transgenic mouse model. Cortical thymoma-thymic carcinoma sequence. (9463585)
1998
34
p53 alteration, proliferating cell nuclear antigen, and nucleolar organizer regions in thymic epithelial tumors. (9852302)
1998
35
Apoptosis, bcl-2 protein, and Fas antigen in thymic epithelial tumors. (9346177)
1997
36
Paraneoplastic myasthenia gravis: detection of anti-MGT30 (titin) antibodies predicts thymic epithelial tumor. (9371941)
1997
37
p53 protein expression and p53 mutation in thymic epithelial tumors. (8623777)
1996
38
Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. Implications for the pathogenesis of myasthenia gravis. (8669470)
1996
39
The MIC2 antibody 013. Practical application for the study of thymic epithelial tumors. (7573670)
1995
40
p53 protein expression and p53 gene mutation in thymic epithelial tumors. An immunohistochemical and DNA sequencing study. (7572785)
1995
41
Cytokeratins in normal thymus and thymic epithelial tumors. (7677978)
1993

Variations for Thymic Epithelial Tumor

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Expression for genes affiliated with Thymic Epithelial Tumor

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thymic Epithelial Tumor

Search GEO for disease gene expression data for Thymic Epithelial Tumor.

Pathways for genes affiliated with Thymic Epithelial Tumor

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 31KEGG, 52PharmGKB, 62Tocris Bioscience, 61Thomson Reuters
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Pathways related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6MMP7, NGFR
2
Show member pathways
9.5NRAS, NGFR
39.3CD5, KIT
4
Show member pathways
9.1KIT, NRAS
5
Show member pathways
Signal transduction PTEN pathway61
9.1KIT, NRAS
69.1NRAS, KIT
7
Show member pathways
8.7NGFR, NRAS, KIT
8
Show member pathways
8.7NGFR, NRAS, KIT
9
Show member pathways
8.7NGFR, NRAS, KIT
10
Show member pathways
8.7KIT, NRAS, NGFR
11
Show member pathways
8.7KIT, NRAS, NGFR
12
Show member pathways
8.7KIT, NRAS, NGFR
13
Show member pathways
8.7NGFR, NRAS, KIT
14
Show member pathways
8.7NGFR, NRAS, KIT
15
Show member pathways
8.7NGFR, NRAS, KIT
16
Show member pathways
8.7KIT, NRAS, NGFR
178.7NGFR, NRAS, KIT
18
Show member pathways
8.7KIT, NRAS, NGFR
19
Show member pathways
8.3KIT, NRAS, MMP7, NGFR

Compounds for genes affiliated with Thymic Epithelial Tumor

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46Novoseek, 52PharmGKB, 12DrugBank, 3BitterDB, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1ganglioside469.6SYP, NGFR
2dbc-amp469.6NGFR, SYP
3catecholamine469.4SYP, NGFR
4irinotecan46 52 1211.3ERCC1, KIT
5p002469.2KIT, MMP7
6chloroquine46 3 52 30 1213.1KIT, SYP
7lead469.0ERCC1, KIT
8doxorubicin46 52 1211.0MMP7, KIT, ERCC1
9hematoxylin468.9KIT, SYP, NGFR
10thymidine46 259.9ERCC1, KIT, NGFR
11phosphotyrosine468.9NGFR, SYP, KIT
12histamine46 30 2510.8KIT, SYP, NGFR
13vincristine46 52 1210.8ERCC1, KIT
14steroid468.6NGFR, SYP, KIT
15phosphatidylinositol468.6NGFR, MMP7, KIT, ERCC1
16leucine468.5NGFR, MMP7, SYP, KIT
17progesterone46 30 62 25 1212.5NGFR, MMP7, SYP, KIT
18nitric oxide46 25 1210.5KIT, SYP, MMP7, NGFR
19retinoic acid46 259.5KIT, SYP, MMP7, NGFR
20cysteine468.4NGFR, MMP7, SYP, KIT
21serine468.4NGFR, MMP7, SYP, KIT
22paraffin468.2NGFR, MMP7, SYP, KIT, CD5
23oligonucleotide468.1NGFR, MMP7, NRAS, KIT, ERCC1
24calcium46 52 25 1211.1NGFR, MMP7, SYP, KIT, CD5
25vegf468.0ERCC1, KIT, SYP, MMP7, NGFR
26estrogen468.0NGFR, MMP7, SYP, KIT, ERCC1
27tyrosine467.1CD5, ERCC1, KIT, NRAS, SYP, MMP7

GO Terms for genes affiliated with Thymic Epithelial Tumor

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17Gene Ontology
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Biological processes related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic signaling pathwayGO:0971909.6CD5, NGFR
2regulation of long-term neuronal synaptic plasticityGO:0481699.4NRAS, SYP
3visual learningGO:0085429.1NRAS, KIT
4male gonad developmentGO:0085849.0ERCC1, KIT
5regulation of cell proliferationGO:0421278.9KIT, MMP7
6neurotrophin TRK receptor signaling pathwayGO:0480118.7KIT, NRAS, NGFR

Molecular functions related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.6CD5, NGFR

Products for genes affiliated with Thymic Epithelial Tumor

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Sources for Thymic Epithelial Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet