MCID: THY042
MIFTS: 36

Thymic Epithelial Tumor malady

Cancer diseases category

Summaries for Thymic Epithelial Tumor

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32MalaCards
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MalaCards: Thymic Epithelial Tumor, also known as epithelial tumor of thymus, is related to thymoma and breast cancer. An important gene associated with Thymic Epithelial Tumor is CD5 (CD5 molecule), and among its related pathways are PTEN Pathway and Degradation of collagen. The compounds butyrate and (4-aminophenyl)mercuric acetate have been mentioned in the context of this disorder. Affiliated tissues include thymus, and related mouse phenotypes are tumorigenesis and respiratory system.

Aliases & Classifications for Thymic Epithelial Tumor

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42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

thymic epithelial tumor 42 60
epithelial tumor of thymus 42
thymoma, adult 42


Related Diseases for Thymic Epithelial Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Thymic Epithelial Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma30.6IFI27, NTRK1, DNTT, NGFR, CD5, MMP14
2breast cancer30.4MKI67, NTRK1, IFI27, TUBB3, TIMP1, TIMP2
3neuroendocrine tumor30.2IFI27, SYP, NTRK1, MKI67
4neuroendocrine carcinoma30.2SYP, MUC1, MMP7, KIT, KRT18
5thymic carcinoma10.4
6myasthenia gravis10.3
7thymic epithelial neoplasm10.3
8cortical thymoma10.1
9thymoma type a10.1
10thymoma type b10.1
11thymoma type ab10.1
12cerebral primitive neuroectodermal tumor10.0CD99
13hepatitis10.0CD99
14pulmonary emphysema10.0TIMP2
15pancreatic islet cell tumors10.0SYP
16uterine carcinosarcoma10.0KIT
17pituitary tumors10.0IFI27
18papilloma10.0IFI27
19malignant mesothelioma10.0MUC1
20testicular cancer10.0ERCC1
21gingivitis10.0TIMP1
22glomus tumor10.0SYP
23primary hyperoxaluria10.0MMP2
24psoriasis10.0KRT18
25desmoid tumor10.0KIT
26pulmonary disease, chronic obstructive10.0TIMP1
27hepatitis b10.0MMP14
28fibromatosis10.0TIMP2, KIT
29teratoma10.0KIT, CD99
30myocardial infarction10.0MMP7
31gastritis10.0KRT18, MMP7
32myeloma10.0IFI27, DNTT
33granular cell tumor10.0NTRK1, SYP
34angiomyolipoma10.0KIT
35anaplastic large cell lymphoma10.0MUC1
36keratoacanthoma10.0MKI67
37paraganglioma10.0SYP, KIT
38myelofibrosis10.0TIMP1, TIMP2
39cystadenocarcinoma10.0MUC1
40myelodysplastic syndromes10.0KIT, DNTT
41dermatofibrosarcoma protuberans10.0MUC1, KIT
42acute leukemia10.0KIT, DNTT
43leiomyoma10.0KIT, MKI67
44encephalomyelitis10.0MMP7
45oligodendroglioma10.0SYP, MKI67
46pilocytic astrocytoma10.0SYP
47sertoli cell tumor10.0SYP, MUC1
48germ cell tumors10.0KIT
49neuroblastoma10.0NGFR, NTRK1, SYP
50hepatitis c10.0CD99, MMP7, KRT18

Graphical network of the top 20 diseases related to Thymic Epithelial Tumor:



Diseases related to thymic epithelial tumor

Clinical Features for Thymic Epithelial Tumor

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Drugs & Therapeutics for Thymic Epithelial Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Thymic Epithelial Tumor

Search CenterWatch for Thymic Epithelial Tumor

Genetic Tests for Thymic Epithelial Tumor

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Anatomical Context for Thymic Epithelial Tumor

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32MalaCards
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MalaCards organs/tissues related to Thymic Epithelial Tumor:

32
Thymus

Animal Models for Thymic Epithelial Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thymic Epithelial Tumor:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.1TIMP1, MMP7, KIT, SLC3A2
2MP:000538810.1TUBB3, NGFR, MMP14, MMP2
3MP:000537610.1NGFR, MMP14, SLC3A2
4MP:001077110.0ERCC1, MMP14, E2F2
5MP:00053919.9E2F2, NTRK1, NGFR, MUC1, MMP14, MMP7
6MP:00036319.6TUBB3, SYP, NTRK1, NGFR, MMP14, KIT
7MP:00053709.4E2F2, NGFR, MUC1, KIT, KRT18, ERCC1
8MP:00053979.3NTRK1, E2F2, TIMP1, TIMP2, DNTT, NGFR
9MP:00028739.3TIMP2, E2F2, SYP, NTRK1, DNTT, NGFR
10MP:00053849.2TUBB3, E2F2, DNTT, NGFR, CD5, MMP14
11MP:00053789.1TIMP1, E2F2, NTRK1, NGFR, MMP14, MMP2
12MP:00053879.0ERCC1, TIMP2, TIMP1, E2F2, NTRK1, DNTT
13MP:00107689.0NGFR, NTRK1, E2F2, TUBB3, TIMP1, MMP14

Publications for Thymic Epithelial Tumor

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Genetic Variations for Thymic Epithelial Tumor

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Expression for genes affiliated with Thymic Epithelial Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thymic Epithelial Tumor

Search GEO for disease gene expression data for Thymic Epithelial Tumor.

Pathways for genes affiliated with Thymic Epithelial Tumor

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51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2NGFR, NTRK1
2
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10.2MMP2, MMP14
3
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10.1NTRK1, NGFR, KIT
410.1MMP14, MMP2, MMP7
510.1KIT, CD5, DNTT
610.0MMP7, MMP2, TIMP1, TIMP2
710.0TIMP2, TIMP1, MMP2, MMP7
8
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9.9TIMP2, TIMP1, NTRK1, NGFR, KIT
9
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9.9TIMP2, TIMP1, NTRK1, NGFR, KIT
10
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9.9KIT, NGFR, NTRK1, TIMP1, TIMP2
11
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9.8TIMP2, TIMP1, MMP14, MMP2, MMP7
12
Cell adhesion ECM remodeling
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9.8TIMP2, TIMP1, MMP14, MMP2, MMP7
13
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9.8MMP7, MMP2, MMP14, TIMP1, TIMP2
14
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9.8TIMP2, TIMP1, MMP14, MMP2, MMP7
159.8NGFR, MKI67, NTRK1, SYP, TUBB3
16
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9.7TIMP2, TIMP1, TUBB3, NTRK1, NGFR, KIT
17
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9.7TIMP2, TIMP1, NTRK1, NGFR, MMP2, KIT
18
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9.6TIMP2, TIMP1, E2F2, NTRK1, NGFR, MMP2
19
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9.3TIMP2, TIMP1, TUBB3, E2F2, NTRK1, NGFR

Compounds for genes affiliated with Thymic Epithelial Tumor

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 2BitterDB, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1butyrate4410.7DNTT
2(4-aminophenyl)mercuric acetate4410.6MMP7, TIMP1
3cycloheximide4410.5NTRK1
4methyl selenol4410.4TIMP1, TIMP2, MMP2
5glutamate4410.2NTRK1, NGFR, SLC3A2
6hydroxamate4410.2TIMP1, MMP2, MMP14, TIMP2
7norcantharidin4410.2MMP2, TIMP2, IFI27, MKI67
8batimastat44 59 1112.2TIMP2, MMP2, TIMP1, MMP14, MMP7
9marimastat44 59 1112.2MMP7, MMP14, TIMP1, MMP2
101,10-phenanthroline44 211.1MMP2, TIMP2, MMP14, TIMP1
11dexamethasone44 49 28 1113.1IFI27, TIMP1, MMP14, KRT18
12dutp4410.1KRT18, MKI67, DNTT, NTRK1, SYP
13paclitaxel44 49 1112.1IFI27, ERCC1, TIMP1, TIMP2, TUBB3
14creatinine4410.1SYP, KRT18, MMP2, NTRK1, TIMP2
15hematoxylin4410.1MUC1, MKI67, SYP, KRT18, NGFR, KIT
16steroid4410.0IFI27, SYP, MKI67, KRT18, NGFR
17p0034410.0MKI67, NTRK1, IFI27, TIMP2, KIT
18ribonucleic acid449.9TIMP1, TIMP2, KIT, MMP7, MUC1, MMP14
195fluorouracil449.9MMP2, MUC1, TIMP2, KIT, ERCC1, MKI67
20bromodeoxyuridine449.9MMP14, KRT18, TUBB3, IFI27, MKI67, DNTT
21agarose449.9KIT, MUC1, MMP14, DNTT, TIMP2
22genistein44 28 59 2 11 2414.8SYP, TIMP1, IFI27, MMP2, MMP14, NTRK1
2312-o-tetradecanoylphorbol 13-acetate449.8TIMP1, NTRK1, DNTT, NGFR, MUC1, TIMP2
24pd 98,059449.8TIMP1, NTRK1, IFI27, TIMP2, MMP14, KIT
25latanoprost44 1110.8TIMP2, TIMP1, MMP2
26p002449.8IFI27, KIT, MMP7, MMP14, MKI67, KRT18
27formaldehyde44 2410.8MUC1, KIT, MKI67, SYP, KRT18
28serine449.8TUBB3, MMP2, MMP14, MKI67, SYP, TIMP1
29matrigel449.7MMP2, TIMP2, TIMP1, NTRK1, NGFR, MMP14
30methotrexate44 49 1111.7MUC1, DNTT, MKI67, TIMP1, MMP2, ERCC1
31phosphatidylinositol449.6KIT, TIMP1, MMP7, IFI27, NTRK1, NGFR
32testosterone44 59 11 2412.6NTRK1, KRT18, MMP2, MUC1, MKI67, SYP
33cisplatin44 49 59 1112.6TIMP1, TUBB3, IFI27, SYP, MKI67, DNTT
34doxorubicin44 49 1111.6ERCC1, KRT18, KIT, MMP7, MKI67, IFI27
35zinc44 2410.6MKI67, TIMP2, MMP14, MMP7, MMP2, NGFR
36ly294002449.5TIMP2, TIMP1, IFI27, NTRK1, MMP14, MMP2
37threonine449.5NGFR, SLC3A2, KRT18, KIT, MKI67, NTRK1
38thymidine44 2410.5TIMP2, IFI27, MKI67, DNTT, NGFR, MMP14
39cysteine449.4SYP, NTRK1, NGFR, MUC1, MMP14, KIT
40lactate449.4MMP14, MMP2, DNTT, MKI67, NTRK1, TIMP2
41oxygen44 2410.4IFI27, KRT18, MMP7, TIMP2, MUC1, NGFR
42lipid449.3MMP14, KRT18, NGFR, MKI67, MUC1, NTRK1
43nitric oxide44 11 2411.3NGFR, DNTT, NTRK1, SYP, TUBB3, TIMP1
44oligonucleotide449.2TIMP2, ERCC1, KRT18, SLC3A2, KIT, MMP7
45progesterone44 59 28 11 2413.1TIMP2, TIMP1, IFI27, SYP, NTRK1, MKI67
46calcium44 49 11 2412.0MUC1, NGFR, MKI67, IFI27, NTRK1, SYP
47retinoic acid44 2410.0KRT18, TIMP2, TIMP1, TUBB3, IFI27, SYP
48vegf448.8MMP7, KIT, KRT18, ERCC1, MMP2, MMP14
49paraffin448.7MMP2, KRT18, KIT, MMP7, MMP14, CD99
50tyrosine448.6ERCC1, CD5, MUC1, NGFR, MKI67, SYP

GO Terms for genes affiliated with Thymic Epithelial Tumor

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16Gene Ontology
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Cellular components related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.8SLC3A2, MUC1, NGFR, NTRK1, TIMP2

Biological processes related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1agingGO:00756810.1NTRK1, TIMP1, TIMP2
2extracellular matrix disassemblyGO:0226179.8MMP7, MMP2, MMP14, TIMP1, TIMP2
3collagen catabolic processGO:0305749.8MMP7, MMP2, MMP14
4extracellular matrix organizationGO:0301989.7TIMP2, TIMP1, MMP14, MMP2, MMP7

Molecular functions related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nerve growth factor bindingGO:04840610.2NGFR, NTRK1
2metalloendopeptidase activityGO:00422210.1MMP7, MMP2, MMP14
3metalloendopeptidase inhibitor activityGO:0081919.9TIMP1, TIMP2
4protein bindingGO:0055158.5TIMP1, E2F2, NTRK1, MKI67, NGFR, MUC1

Products for genes affiliated with Thymic Epithelial Tumor

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  • Antibodies
  • Proteins
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Sources for Thymic Epithelial Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet