MCID: THY042
MIFTS: 40

Thymic Epithelial Tumor malady

Cancer category

Summaries for Thymic Epithelial Tumor

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33MalaCards
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MalaCards: Thymic Epithelial Tumor, also known as epithelial tumor of thymus, is related to thymoma and thymic carcinoma. An important gene associated with Thymic Epithelial Tumor is CD5 (CD5 molecule), and among its related pathways are PTEN Pathway and Degradation of collagen. The compounds butyrate and (4-aminophenyl)mercuric acetate have been mentioned in the context of this disorder. Affiliated tissues include thymus, heart and breast, and related mouse phenotypes are tumorigenesis and respiratory system.

Aliases & Classifications for Thymic Epithelial Tumor

Sources:
43NIH Rare Diseases, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

thymic epithelial tumor 43 61
epithelial tumor of thymus 43
thymoma, adult 43


Related Diseases for Thymic Epithelial Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Thymic Epithelial Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma30.6IFI27, NTRK1, DNTT, NGFR, CD5, MMP14
2thymic carcinoma30.5KIT, KRT18, CD5, MUC1, NGFR, SYP
3neuroendocrine carcinoma30.2SYP, MUC1, MMP7, KIT, KRT18
4thymic epithelial neoplasm10.3
5cortical thymoma10.1
6type c thymoma10.1
7heart tumor10.1
8breast cancer susceptibility10.1
9thymoma type a10.1
10thymoma type b10.1
11thymoma type ab10.1
12thymic neuroendocrine carcinoma10.1
13cerebral primitive neuroectodermal tumor10.0CD99
14hepatitis10.0CD99
15pulmonary emphysema10.0TIMP2
16pancreatic islet cell tumors10.0SYP
17uterine carcinosarcoma10.0KIT
18pituitary tumors10.0IFI27
19papilloma10.0IFI27
20malignant mesothelioma10.0MUC1
21testicular cancer10.0ERCC1
22gingivitis10.0TIMP1
23glomus tumor10.0SYP
24primary hyperoxaluria10.0MMP2
25psoriasis10.0KRT18
26desmoid tumor10.0KIT
27pulmonary disease, chronic obstructive10.0TIMP1
28hepatitis b10.0MMP14
29fibromatosis10.0TIMP2, KIT
30teratoma10.0KIT, CD99
31myocardial infarction10.0MMP7
32gastritis10.0KRT18, MMP7
33myeloma10.0IFI27, DNTT
34granular cell tumor10.0NTRK1, SYP
35angiomyolipoma10.0KIT
36anaplastic large cell lymphoma10.0MUC1
37keratoacanthoma10.0MKI67
38paraganglioma10.0SYP, KIT
39myelofibrosis10.0TIMP1, TIMP2
40cystadenocarcinoma10.0MUC1
41myelodysplastic syndromes10.0KIT, DNTT
42dermatofibrosarcoma protuberans10.0MUC1, KIT
43acute leukemia10.0KIT, DNTT
44leiomyoma10.0KIT, MKI67
45encephalomyelitis10.0MMP7
46oligodendroglioma10.0SYP, MKI67
47pilocytic astrocytoma10.0SYP
48sertoli cell tumor10.0SYP, MUC1
49germ cell tumors10.0KIT
50neuroblastoma10.0NGFR, NTRK1, SYP

Graphical network of the top 20 diseases related to Thymic Epithelial Tumor:



Diseases related to thymic epithelial tumor

Clinical Features for Thymic Epithelial Tumor

Drugs & Therapeutics for Thymic Epithelial Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Thymic Epithelial Tumor

Drug clinical trials:

Search ClinicalTrials for Thymic Epithelial Tumor

Search NIH Clinical Center for Thymic Epithelial Tumor

Search CenterWatch for Thymic Epithelial Tumor

Genetic Tests for Thymic Epithelial Tumor

Anatomical Context for Thymic Epithelial Tumor

Sources:
33MalaCards
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MalaCards organs/tissues related to Thymic Epithelial Tumor:

33
Thymus, Heart, Breast, T cells

Animal Models for Thymic Epithelial Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Thymic Epithelial Tumor

Sources:
51PubMed
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Articles related to Thymic Epithelial Tumor:

(show all 47)
idTitleAuthorsYear
1
Tumor-to-tumor metastasis: breast cancer metastatic to thymic epithelial tumor. (23695010)
2013
2
NUT rearrangement is uncommon in human thymic epithelial tumors. (22425924)
2012
3
Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systems. (22974165)
2012
4
Is There a Role of Postoperative Radiation Therapy in Completely Resected Stage I/II Thymic Epithelial Tumor? (23091442)
2012
5
Expression of excision repair cross-complementation group 1, breast cancer susceptibility 1, and I^ III-tubulin in thymic epithelial tumors. (21289518)
2011
6
MUC1 expression in thymic epithelial tumors: MUC1 may be useful marker as differential diagnosis between type B3 thymoma and thymic carcinoma. (21253760)
2011
7
Expression of proteasome subunit I^5t in thymic epithelial tumors. (21836487)
2011
8
Successful diagnosis of a combined thymic epithelial tumor by endobronchial ultrasound-guided transbronchial needle aspiration. (23896935)
2011
9
Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors. (21372220)
2011
10
Expression and mutational status of c-kit in thymic epithelial tumors. (20651610)
2010
11
Thymic epithelial tumor with heart metastasis in a horse. (20814442)
2010
12
Characterization of T cell maturity in thymic epithelial cell tumors from BUF/Mna spontaneous thymoma rats and BUF/Mna-Rnu/+ rats showing delayed thymomagenesis. (20661406)
2010
13
CD98 expression is associated with the grade of malignancy in thymic epithelial tumors. (20811665)
2010
14
Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report. (19901887)
2009
15
Computed tomographic findings and prognosis in thymic epithelial tumor patients. (18830115)
2008
16
Absence of gene mutations in KIT-positive thymic epithelial tumors. (18486988)
2008
17
Adjuvant radiotherapy for thymic epithelial tumor: treatment results and prognostic factors. (17762439)
2007
18
Expression of tumor-associated differentiation antigens, MUC1 glycoforms and CEA, in human thymic epithelial cells: implications for self-tolerance and tumor therapy. (17440107)
2007
19
Correlation between MMP-2 activation and MT1-MMP mRNA expression in thymic epithelial tumors]. (16608644)
2006
20
Expression and mutation statuses of epidermal growth factor receptor in thymic epithelial tumors. (16762968)
2006
21
Multimodality treatment program in invasive thymic epithelial tumor. (15685027)
2005
22
Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire. (16024649)
2005
23
Expression of neurotrophin receptors in surgically resected thymic epithelial tumors. (16125946)
2005
24
Immunohistochemical KIT (CD117) expression in thymic epithelial tumors. (16002927)
2005
25
Expression of cyclins D1, D3 and p27 in thymic epithelial tumors. (17670226)
2004
26
High incidence of thymic epithelial tumors in E2F2 transgenic mice. (14684733)
2004
27
KI-67 antigen expression predicts survival and correlates with histologic subtype in the WHO classification of thymic epithelial tumors. (15494865)
2004
28
Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors. (14584061)
2003
29
Expression of matrix metalloproteinases 2 and 7 in tumor cells correlates with the World Health Organization classification subtype and clinical stage of thymic epithelial tumors. (14691910)
2003
30
Apoptosis in thymic epithelial tumors. (12234065)
2002
31
Thymic epithelial tumors can develop along two different pathogenetic pathways. (11696445)
2001
32
Activation of matrix metalloproteinase-2 is correlated with invasiveness in thymic epithelial tumors. (11276020)
2001
33
Differential expression of NGF receptors in human thymic epithelial tumors. (10483585)
1999
34
Thymocyte-thymic epithelial cell interaction leads to high-level replication of human immunodeficiency virus exclusively in mature CD4(+) CD8(-) CD3(+) thymocytes: a critical role for tumor necrosis factor and interleukin-7. (10438843)
1999
35
Correlation between clinical aggressiveness of thymic epithelial tumors and expression of tumor suppressor gene products (p53, p27)]. (10496046)
1999
36
Neuroendocrine differentiation in thymic epithelial tumors with special reference to thymic carcinoma and atypical thymoma. (9563781)
1998
37
Thymic epithelial tumor progression in an SV40T transgenic mouse model. Cortical thymoma-thymic carcinoma sequence. (9463585)
1998
38
p53 alteration, proliferating cell nuclear antigen, and nucleolar organizer regions in thymic epithelial tumors. (9852302)
1998
39
Mature CD4 single positive thymocytes in human Thymoma: T cells may differentiate in the thymic epithelial cell tumor. (9396046)
1997
40
Apoptosis, bcl-2 protein, and Fas antigen in thymic epithelial tumors. (9346177)
1997
41
Paraneoplastic myasthenia gravis: detection of anti-MGT30 (titin) antibodies predicts thymic epithelial tumor. (9371941)
1997
42
Cell kinetic study of thymic epithelial tumors using PCNA (PC10) and Ki-67 (MIB-1) antibodies. (8543314)
1996
43
p53 protein expression and p53 mutation in thymic epithelial tumors. (8623777)
1996
44
Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. Implications for the pathogenesis of myasthenia gravis. (8669470)
1996
45
The MIC2 antibody 013. Practical application for the study of thymic epithelial tumors. (7573670)
1995
46
p53 protein expression and p53 gene mutation in thymic epithelial tumors. An immunohistochemical and DNA sequencing study. (7572785)
1995
47
Cytokeratins in normal thymus and thymic epithelial tumors. (7677978)
1993

Genetic Variations for Thymic Epithelial Tumor

Expression for genes affiliated with Thymic Epithelial Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Thymic Epithelial Tumor

Search GEO for disease gene expression data for Thymic Epithelial Tumor.

Pathways for genes affiliated with Thymic Epithelial Tumor

Sources:
52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology, 12EMD Millipore
See all sources

Pathways related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2NGFR, NTRK1
2
Hide members
10.2MMP2, MMP14
3
Hide members
10.1NTRK1, NGFR, KIT
410.1MMP14, MMP2, MMP7
510.1KIT, CD5, DNTT
610.0MMP7, MMP2, TIMP1, TIMP2
710.0TIMP2, TIMP1, MMP2, MMP7
8
Hide members
9.9TIMP2, TIMP1, NTRK1, NGFR, KIT
9
Hide members
9.9TIMP2, TIMP1, NTRK1, NGFR, KIT
10
Hide members
9.9KIT, NGFR, NTRK1, TIMP1, TIMP2
11
Hide members
9.8TIMP2, TIMP1, MMP14, MMP2, MMP7
12
Cell adhesion ECM remodeling
Hide members
9.8TIMP2, TIMP1, MMP14, MMP2, MMP7
13
Hide members
9.8MMP7, MMP2, MMP14, TIMP1, TIMP2
14
Hide members
9.8TIMP2, TIMP1, MMP14, MMP2, MMP7
159.8NGFR, MKI67, NTRK1, SYP, TUBB3
16
Hide members
9.7TIMP2, TIMP1, TUBB3, NTRK1, NGFR, KIT
17
Hide members
9.7TIMP2, TIMP1, NTRK1, NGFR, MMP2, KIT
18
Hide members
9.6TIMP2, TIMP1, E2F2, NTRK1, NGFR, MMP2
19
Hide members
9.3TIMP2, TIMP1, TUBB3, E2F2, NTRK1, NGFR

Compounds for genes affiliated with Thymic Epithelial Tumor

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 2BitterDB, 50PharmGKB, 29IUPHAR, 24HMDB
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Compounds related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1butyrate4510.7DNTT
2(4-aminophenyl)mercuric acetate4510.6MMP7, TIMP1
3cycloheximide4510.5NTRK1
4methyl selenol4510.4TIMP1, TIMP2, MMP2
5glutamate4510.2NTRK1, NGFR, SLC3A2
6hydroxamate4510.2TIMP1, MMP2, MMP14, TIMP2
7norcantharidin4510.2MMP2, TIMP2, IFI27, MKI67
8batimastat45 60 1112.2TIMP2, MMP2, TIMP1, MMP14, MMP7
9marimastat45 60 1112.2MMP7, MMP14, TIMP1, MMP2
101,10-phenanthroline45 211.1MMP2, TIMP2, MMP14, TIMP1
11dexamethasone45 50 29 1113.1IFI27, TIMP1, MMP14, KRT18
12dutp4510.1KRT18, MKI67, DNTT, NTRK1, SYP
13paclitaxel45 50 1112.1IFI27, ERCC1, TIMP1, TIMP2, TUBB3
14creatinine4510.1SYP, KRT18, MMP2, NTRK1, TIMP2
15hematoxylin4510.1MUC1, MKI67, SYP, KRT18, NGFR, KIT
16steroid4510.0IFI27, SYP, MKI67, KRT18, NGFR
17p0034510.0MKI67, NTRK1, IFI27, TIMP2, KIT
18ribonucleic acid459.9TIMP1, TIMP2, KIT, MMP7, MUC1, MMP14
195fluorouracil459.9MMP2, MUC1, TIMP2, KIT, ERCC1, MKI67
20bromodeoxyuridine459.9MMP14, KRT18, TUBB3, IFI27, MKI67, DNTT
21agarose459.9KIT, MUC1, MMP14, DNTT, TIMP2
22genistein45 29 60 2 11 2414.8SYP, TIMP1, IFI27, MMP2, MMP14, NTRK1
2312-o-tetradecanoylphorbol 13-acetate459.8TIMP1, NTRK1, DNTT, NGFR, MUC1, TIMP2
24pd 98,059459.8TIMP1, NTRK1, IFI27, TIMP2, MMP14, KIT
25latanoprost45 1110.8TIMP2, TIMP1, MMP2
26p002459.8IFI27, KIT, MMP7, MMP14, MKI67, KRT18
27formaldehyde45 2410.8MUC1, KIT, MKI67, SYP, KRT18
28serine459.8TUBB3, MMP2, MMP14, MKI67, SYP, TIMP1
29matrigel459.7MMP2, TIMP2, TIMP1, NTRK1, NGFR, MMP14
30methotrexate45 50 1111.7MUC1, DNTT, MKI67, TIMP1, MMP2, ERCC1
31phosphatidylinositol459.6KIT, TIMP1, MMP7, IFI27, NTRK1, NGFR
32testosterone45 60 11 2412.6NTRK1, KRT18, MMP2, MUC1, MKI67, SYP
33cisplatin45 50 60 1112.6TIMP1, TUBB3, IFI27, SYP, MKI67, DNTT
34doxorubicin45 50 1111.6ERCC1, KRT18, KIT, MMP7, MKI67, IFI27
35zinc45 2410.6MKI67, TIMP2, MMP14, MMP7, MMP2, NGFR
36ly294002459.5TIMP2, TIMP1, IFI27, NTRK1, MMP14, MMP2
37threonine459.5NGFR, SLC3A2, KRT18, KIT, MKI67, NTRK1
38thymidine45 2410.5TIMP2, IFI27, MKI67, DNTT, NGFR, MMP14
39cysteine459.4SYP, NTRK1, NGFR, MUC1, MMP14, KIT
40lactate459.4MMP14, MMP2, DNTT, MKI67, NTRK1, TIMP2
41oxygen45 2410.4IFI27, KRT18, MMP7, TIMP2, MUC1, NGFR
42lipid459.3MMP14, KRT18, NGFR, MKI67, MUC1, NTRK1
43nitric oxide45 11 2411.3NGFR, DNTT, NTRK1, SYP, TUBB3, TIMP1
44oligonucleotide459.2TIMP2, ERCC1, KRT18, SLC3A2, KIT, MMP7
45progesterone45 60 29 11 2413.1TIMP2, TIMP1, IFI27, SYP, NTRK1, MKI67
46calcium45 50 11 2412.0MUC1, NGFR, MKI67, IFI27, NTRK1, SYP
47retinoic acid45 2410.0KRT18, TIMP2, TIMP1, TUBB3, IFI27, SYP
48vegf458.8MMP7, KIT, KRT18, ERCC1, MMP2, MMP14
49paraffin458.7MMP2, KRT18, KIT, MMP7, MMP14, CD99
50tyrosine458.6ERCC1, CD5, MUC1, NGFR, MKI67, SYP

GO Terms for genes affiliated with Thymic Epithelial Tumor

Sources:
16Gene Ontology
See all sources

Cellular components related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.8SLC3A2, MUC1, NGFR, NTRK1, TIMP2

Biological processes related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1agingGO:00756810.1NTRK1, TIMP1, TIMP2
2extracellular matrix disassemblyGO:0226179.8MMP7, MMP2, MMP14, TIMP1, TIMP2
3collagen catabolic processGO:0305749.8MMP7, MMP2, MMP14
4extracellular matrix organizationGO:0301989.7TIMP2, TIMP1, MMP14, MMP2, MMP7

Molecular functions related to Thymic Epithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nerve growth factor bindingGO:04840610.2NGFR, NTRK1
2metalloendopeptidase activityGO:00422210.1MMP7, MMP2, MMP14
3metalloendopeptidase inhibitor activityGO:0081919.9TIMP1, TIMP2
4protein bindingGO:0055158.5TIMP1, E2F2, NTRK1, MKI67, NGFR, MUC1

Products for genes affiliated with Thymic Epithelial Tumor

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thymic Epithelial Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet