MCID: THY043
MIFTS: 28

Thymic Hyperplasia malady

Endocrine diseases category

Summaries for Thymic Hyperplasia

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32MalaCards
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MalaCards: Thymic Hyperplasia, also known as hyperplasia of thymus gland, is related to thymoma and thyroiditis. An important gene associated with Thymic Hyperplasia is RPE65 (retinal pigment epithelium-specific protein 65kDa), and among its related pathways are HTLV-I infection and Class A/1 (Rhodopsin-like receptors). The compounds noxa and indole-3-carbinol have been mentioned in the context of this disorder. Affiliated tissues include thymus, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Thymic Hyperplasia

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42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

thymic hyperplasia 42
hyperplasia of thymus gland 42
thymus hyperplasia 60


Related Diseases for Thymic Hyperplasia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Thymic Hyperplasia:



Diseases related to thymic hyperplasia

Clinical Features for Thymic Hyperplasia

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Drugs & Therapeutics for Thymic Hyperplasia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Thymic Hyperplasia

Search CenterWatch for Thymic Hyperplasia

Genetic Tests for Thymic Hyperplasia

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Anatomical Context for Thymic Hyperplasia

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32MalaCards
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MalaCards organs/tissues related to Thymic Hyperplasia:

32
Thymus

Animal Models for Thymic Hyperplasia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thymic Hyperplasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.2TSHR, POMC, RPE65
2MP:00053798.9CCND1, XIAP, PTTG1, TSHR
3MP:00053867.7RPE65, TP63, TSHR, PTTG1, POMC, XIAP
4MP:00053977.6CCND1, XIAP, CXCL13, PTTG1, TSHR, POMC
5MP:00053877.1CCND1, XIAP, POMC, CXCL13, PTTG1, TSHR
6MP:00053847.0TSHR, PTTG1, CXCL13, POMC, XIAP, CCND1

Publications for Thymic Hyperplasia

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Genetic Variations for Thymic Hyperplasia

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Expression for genes affiliated with Thymic Hyperplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thymic Hyperplasia

Search GEO for disease gene expression data for Thymic Hyperplasia.

Pathways for genes affiliated with Thymic Hyperplasia

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29KEGG, 53Reactome
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Pathways related to Thymic Hyperplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1PTTG1, XIAP, CCND1
2
Hide members
8.4TSHR, CXCL13, POMC, CCL21

Compounds for genes affiliated with Thymic Hyperplasia

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Sources:
44Novoseek, 2BitterDB, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Thymic Hyperplasia according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1noxa449.9TP63, XIAP
2indole-3-carbinol449.8CCND1, XIAP
3estrogen449.8PTTG1, TSHR
4methimazole44 2 1111.8POMC, TSHR
5suberoylanilide hydroxamic acid449.7XIAP, CCND1
6vincristine44 49 1111.7CCND1, XIAP, POMC
7sulindac44 1110.6CCND1, XIAP
8dutp449.4CCND1, XIAP
9teck449.4CCL21, CXCL13
10estradiol44 11 2411.3XIAP, POMC, TSHR, CCND1
11agar449.3CCND1, XIAP, PTTG1
12ribonucleic acid449.3TSHR, PTTG1, POMC
13progesterone44 59 28 11 2413.1POMC, TSHR, TP63, CCND1
14retinoic acid44 249.9RPE65, TP63, CCND1, XIAP, TSHR
15paraffin448.9CCND1, XIAP, TP63, POMC, TSHR
16thymidine44 249.9CCND1, PTTG1, TSHR, TP63
17phosphatidylinositol448.9PTTG1, TSHR, CCND1, XIAP
18vegf448.0POMC, CCND1, XIAP, PTTG1, TSHR, TP63
19calcium44 49 11 2410.6TP63, TSHR, PTTG1, CXCL13, XIAP, CCL21

GO Terms for genes affiliated with Thymic Hyperplasia

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16Gene Ontology
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Biological processes related to Thymic Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:0101659.6TP63, CCND1
2mitotic G1 DNA damage checkpointGO:0315719.3TP63, CCND1
3cell-cell signalingGO:0072678.3TSHR, CXCL13, POMC, CCL21

Molecular functions related to Thymic Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.1CXCL13, CCL21

Products for genes affiliated with Thymic Hyperplasia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thymic Hyperplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet