MCID: THY043
MIFTS: 32

Thymic Hyperplasia malady

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Thymic Hyperplasia

Aliases & Descriptions for Thymic Hyperplasia:

Name: Thymic Hyperplasia 50
Hyperplasia of Thymus Gland 50
Thymus Hyperplasia 69

Classifications:



Summaries for Thymic Hyperplasia

MalaCards based summary : Thymic Hyperplasia, also known as hyperplasia of thymus gland, is related to graves' disease and myasthenia gravis. An important gene associated with Thymic Hyperplasia is AKTIP (AKT Interacting Protein), and among its related pathways/superpathways are Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions and amb2 Integrin signaling. Affiliated tissues include thymus, t cells and thyroid, and related phenotypes are hematopoietic system and immune system

Related Diseases for Thymic Hyperplasia

Diseases related to Thymic Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
id Related Disease Score Top Affiliating Genes
1 graves' disease 10.3
2 myasthenia gravis 10.2
3 lymphoma 10.2
4 mediastinitis 10.1
5 thymoma 10.1
6 hyperthyroidism 9.9
7 testicular germ cell tumor 9.8
8 thyroiditis 9.8
9 breast cancer 9.7
10 hodgkin lymphoma 9.7
11 thyroid cancer 9.7
12 thymic epithelial tumor 9.7
13 lambert-eaton myasthenic syndrome 9.7
14 goiter 9.7
15 cushing's syndrome 9.7
16 neuronitis 9.6
17 nodular goiter 9.6
18 beckwith-wiedemann syndrome 9.6
19 pure red-cell aplasia 9.6
20 myocarditis 9.6
21 burkitt lymphoma 9.6
22 myeloid leukemia 9.6
23 pericarditis 9.6
24 lupus erythematosus 9.6
25 b-cell lymphomas 9.6
26 acromegaly 9.6
27 encephalitis 9.6
28 burns 9.6
29 cervicitis 9.6
30 hemihypertrophy 9.6
31 leukemia 9.6
32 lipomatosis 9.6
33 myelitis 9.6
34 transverse myelitis 9.6
35 thrombocytopenia 9.6
36 pituitary tumors 9.6
37 congenital myasthenic syndrome 9.6
38 myopathy 9.6
39 sialadenitis 9.6
40 myositis 9.6
41 sarcoma 9.6
42 acquired immunodeficiency syndrome 9.6
43 neuroblastoma 9.6
44 systemic lupus erythematosus 9.6
45 tibial hemimelia cleft lip palate 8.4 AGER AKTIP CCL21 CCR7 CXCL13 HMGB1

Graphical network of the top 20 diseases related to Thymic Hyperplasia:



Diseases related to Thymic Hyperplasia

Symptoms & Phenotypes for Thymic Hyperplasia

MGI Mouse Phenotypes related to Thymic Hyperplasia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 CXCL13 PTTG1 RPE65 TSHR XIAP AGER
2 immune system MP:0005387 9.23 PTTG1 RPE65 TP63 TSHR XIAP AGER

Drugs & Therapeutics for Thymic Hyperplasia

Interventional clinical trials:


id Name Status NCT ID Phase
1 The Role of the Thymus in Myasthenia Gravis Active, not recruiting NCT01102192

Search NIH Clinical Center for Thymic Hyperplasia

Genetic Tests for Thymic Hyperplasia

Anatomical Context for Thymic Hyperplasia

MalaCards organs/tissues related to Thymic Hyperplasia:

39
Thymus, T Cells, Thyroid, Breast, Lung, Pituitary, Hypothalamus

Publications for Thymic Hyperplasia

Articles related to Thymic Hyperplasia:

(show top 50) (show all 189)
id Title Authors Year
1
Rebound thymic hyperplasia following high dose chemotherapy and stem cell transplant in three neuroblastoma patients. ( 27663277 )
2016
2
Myasthenia gravis accompanied by Graves' disease, thyrotoxic hypokalemic periodic paralysis and thymic hyperplasia. ( 27381127 )
2016
3
Graves' Patient with Thymic Expression of Thyrotropin Receptors and Dynamic Changes in Thymic Hyperplasia Proportional to Graves' Disease Activity. ( 26996584 )
2016
4
Thymic Hyperplasia After Treatment of ACTH-Dependent Cushing's Syndrome Can Be Mistaken for a Thymic Epithelial Tumor. ( 27865872 )
2016
5
Rebound Thymic Hyperplasia after Chemotherapy in Children with Lymphoma. ( 27364860 )
2016
6
Thymic hyperplasia and its spontaneous resolution with treatment of Graves' hyperthyroidism. ( 27190120 )
2016
7
Thymic hyperplasia after chemotherapy in adults with mature B cell lymphoma and its influence on thymic output and CD4(+) T cells repopulation. ( 27467956 )
2016
8
Clinical Outcomes of Myasthenia Gravis with Thymoma and Thymic Hyperplasia Undergoing Extended Transsternal Thymectomy: A Single-Center Experience. ( 26713298 )
2015
9
High rate of unnecessary thymectomy and its cause. Can computed tomography distinguish thymoma, lymphoma, thymic hyperplasia, and thymic cysts? ( 25575742 )
2015
10
A unilocular thymic cyst associated with true thymic hyperplasia: a challenging diagnosis especially in a child. ( 26445562 )
2015
11
Congenital myasthenic syndrome due to mutation in CHRNE gene with clinical worsening and thymic hyperplasia attributed to association with autoimmune-myasthenia gravis. ( 26363966 )
2015
12
Thymic hyperplasia and chylothorax. ( 25976649 )
2015
13
Reply to "Usefulness of CT in differentiating lymphoid thymic hyperplasia from true thymic hyperplasia: added value of thymic measurements and CT attenuation". ( 25539268 )
2015
14
Massive thymic hyperplasia in a neonate with Beckwith-Weidemann syndrome. ( 26364853 )
2015
15
Diffusion-weighted MRI in a case of nonsuppressing rebound thymic hyperplasia on chemical-shift MRI. ( 25556605 )
2015
16
Usefulness of CT in differentiating lymphoid thymic hyperplasia from true thymic hyperplasia: added value of thymic measurements and CT attenuation. ( 25539267 )
2015
17
Synchronous triple thymoma and true thymic hyperplasia simultaneously detected by (18)F FDG PET-CT. ( 25771094 )
2015
18
Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology. ( 24705787 )
2014
19
Thymic hyperplasia following chemotherapy in adults with lymphoma: (18)F-FDG PET/CT findings and correlation with the T cell repopulation. ( 25407653 )
2014
20
An adolescent with Graves' disease and thymic hyperplasia. ( 24605862 )
2014
21
Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia. ( 24556356 )
2014
22
Imaging of thymus in myasthenia gravis: from thymic hyperplasia to thymic tumor. ( 24581970 )
2014
23
Rebound Thymic Hyperplasia Detected by (18)F-FDG PET/CT After Radioactive Iodine Ablation Therapy for Thyroid Cancer. ( 25065897 )
2014
24
Differentiation of Rebound and Lymphoid Thymic Hyperplasia from Anterior Mediastinal Tumors with Dual-Echo Chemical-Shift MR Imaging in Adulthood: Reliability of the Chemical-Shift Ratio and Signal Intensity Index. ( 25105246 )
2014
25
Thymic hyperplasia in patients with Graves' disease. ( 25149085 )
2014
26
Thymic measurements in pathologically proven normal thymus and thymic hyperplasia: intraobserver and interobserver variabilities. ( 24809315 )
2014
27
Chemical-shift MRI of rebound thymic hyperplasia with unusual appearance and intense (18)F-FDG uptake in adulthood: report of two cases. ( 24667047 )
2014
28
Reactive thymic hyperplasia following chemotherapy for children with lymphoma: computed tomography may be able to provide valuable information to avoid over-treatment. ( 25079775 )
2014
29
Imaging characteristics of pathologically proven thymic hyperplasia: identifying features that can differentiate true from lymphoid hyperplasia. ( 24555583 )
2014
30
Anti NMDA receptor encephalitis associated with thymic hyperplasia: a case report. ( 25033868 )
2014
31
Graves' disease and thymic hyperplasia. ( 24238061 )
2013
32
FDG PET/CT findings of thyrotoxicosis induced thymic hyperplasia associated to interferon. ( 23036823 )
2013
33
Hypokalemic periodic paralysis induced by thymic hyperplasia and relieved by thymectomy. ( 24061198 )
2013
34
Thymic hyperplasia in Graves' disease. ( 23869315 )
2013
35
Severe thymic hyperplasia in a newborn calf associated with impaired T-cell differentiation. ( 23864259 )
2013
36
Pericarditis, thymic hyperplasia, and Graves' thyrotoxicosis: case report and review of the literature. ( 23820368 )
2013
37
Thymic hyperplasia with lymphoepithelial sialadenitis (LESA)-like features: a clinicopathologic and immunohistochemical study of 4 cases. ( 23161715 )
2012
38
Thymic hyperplasia in a patient with Grave's disease. ( 22321290 )
2012
39
Thymic hyperplasia after lung transplantation imitating posttransplant lymphoproliferative disorder. ( 23213605 )
2011
40
Lambert-Eaton myasthenic syndrome and follicular thymic hyperplasia in systemic lupus erythematosus. ( 21427136 )
2011
41
Visual vignette. What is the diagnosis? Thymic hyperplasia associated with Graves disease. ( 21803716 )
2011
42
Thymic hyperplasia in Graves' disease. ( 22189747 )
2011
43
Thymic Hyperplasia Associated with Graves' Disease in a 10-year-old Boy. ( 23926397 )
2011
44
Unusual thymic hyperplasia mimicking lipomatous tumor in an eight-year-old boy with concomitant pericardial lipomatosis and right facial hemihypertrophy. ( 21603297 )
2011
45
True thymic hyperplasia associated with thymic hemorrhage in an adult patient. ( 19640657 )
2010
46
True thymic hyperplasia in an infant. ( 20713225 )
2010
47
Massive thymic hyperplasia presenting with respiratory insufficiency in a 2-year-old child. ( 20522860 )
2010
48
Our experience in thymic hyperplasia using 67Ga-citrate, 111In-pentetreotide and 201Tl-chloride. ( 20505931 )
2010
49
An adolescent with a mediastinal mass, diagnosed with Graves disease and thymic hyperplasia. ( 20100762 )
2010
50
Graves' disease and thymic hyperplasia: the relationship of thymic volume to thyroid function. ( 20718680 )
2010

Variations for Thymic Hyperplasia

Expression for Thymic Hyperplasia

Search GEO for disease gene expression data for Thymic Hyperplasia.

Pathways for Thymic Hyperplasia

Pathways related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.22 CCL21 CCR7 CXCL13
2 10.84 AGER HMGB1
3 9.74 AGER HMGB1

GO Terms for Thymic Hyperplasia

Biological processes related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.8 AGER CXCL13 TSHR
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 CCL21 CCR7 HMGB1
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.73 CCR7 CXCL13 HMGB1
4 activation of GTPase activity GO:0090630 9.69 CCL21 CCR7 CXCL13
5 chemokine-mediated signaling pathway GO:0070098 9.65 CCL21 CCR7 CXCL13
6 positive regulation of actin filament polymerization GO:0030838 9.62 CCL21 CCR7
7 release of sequestered calcium ion into cytosol GO:0051209 9.61 CCL21 CCR7
8 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.61 CCL21 CCR7
9 positive regulation of JNK cascade GO:0046330 9.61 CCL21 CCR7 HMGB1
10 positive regulation of filopodium assembly GO:0051491 9.6 CCL21 CCR7
11 positive regulation of neutrophil chemotaxis GO:0090023 9.59 CCL21 CCR7
12 positive regulation of activated T cell proliferation GO:0042104 9.58 AGER HMGB1
13 positive regulation of cell-matrix adhesion GO:0001954 9.57 CCL21 CCR7
14 chemotaxis GO:0006935 9.56 CCL21 CCR7 CXCL13 HMGB1
15 positive regulation of cell motility GO:2000147 9.55 CCL21 CCR7
16 inflammatory response GO:0006954 9.55 AGER CCL21 CCR7 CXCL13 HMGB1
17 ruffle organization GO:0031529 9.54 CCL21 CCR7
18 positive regulation of pseudopodium assembly GO:0031274 9.52 CCL21 CCR7
19 response to prostaglandin E GO:0034695 9.49 CCL21 CCR7
20 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.46 CCL21 CCR7
21 positive regulation of dendritic cell differentiation GO:2001200 9.4 AGER HMGB1
22 establishment of T cell polarity GO:0001768 9.37 CCL21 CCR7
23 negative regulation of leukocyte apoptotic process GO:2000107 9.32 CCL21 CCR7
24 positive regulation of interleukin-12 production GO:0032735 9.13 AGER CCR7 HMGB1
25 dendritic cell chemotaxis GO:0002407 8.8 CCL21 CCR7 HMGB1

Molecular functions related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL21 CXCL13
2 phosphatidylserine binding GO:0001786 9.16 HMGB1 RPE65
3 cysteine-type endopeptidase inhibitor activity GO:0004869 8.96 PTTG1 XIAP
4 cytokine activity GO:0005125 8.8 CCL21 CXCL13 HMGB1

Sources for Thymic Hyperplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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