MCID: THY043
MIFTS: 32

Thymic Hyperplasia malady

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Thymic Hyperplasia

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Aliases & Descriptions for Thymic Hyperplasia:

Name: Thymic Hyperplasia 46
Hyperplasia of Thymus Gland 46
 
Thymus Hyperplasia 66

Classifications:



Summaries for Thymic Hyperplasia

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MalaCards based summary: Thymic Hyperplasia, also known as hyperplasia of thymus gland, is related to graves' disease and myasthenia gravis. An important gene associated with Thymic Hyperplasia is AKTIP (AKT Interacting Protein), and among its related pathways are Advanced glycosylation endproduct receptor signaling and amb2 Integrin signaling. Affiliated tissues include thymus, t cells and thyroid, and related mouse phenotypes are vision/eye and hematopoietic system.

Related Diseases for Thymic Hyperplasia

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Graphical network of the top 20 diseases related to Thymic Hyperplasia:



Diseases related to thymic hyperplasia

Symptoms for Thymic Hyperplasia

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Drugs & Therapeutics for Thymic Hyperplasia

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Interventional clinical trials:

idNameStatusNCT IDPhase
1The Role of the Thymus in Myasthenia GravisActive, not recruitingNCT01102192

Search NIH Clinical Center for Thymic Hyperplasia

Genetic Tests for Thymic Hyperplasia

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Anatomical Context for Thymic Hyperplasia

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MalaCards organs/tissues related to Thymic Hyperplasia:

34
Thymus, T cells, Thyroid, Breast, Lung, Pituitary, Hypothalamus

Animal Models for Thymic Hyperplasia or affiliated genes

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MGI Mouse Phenotypes related to Thymic Hyperplasia:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6AKTIP, CCR7, RPE65, TP63, TSHR
2MP:00053977.1AGER, CCR7, CXCL13, PTTG1, RPE65, TSHR
3MP:00053877.0AGER, CCR7, CXCL13, PTTG1, RPE65, TP63

Publications for Thymic Hyperplasia

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Articles related to Thymic Hyperplasia:

(show top 50)    (show all 188)
idTitleAuthorsYear
1
Thymic hyperplasia after chemotherapy in adults with mature B cell lymphoma and its influence on thymic output and CD4(+) T cells repopulation. (27467956)
2016
2
Thymic hyperplasia and chylothorax. (25976649)
2015
3
Chemical-shift MRI of rebound thymic hyperplasia with unusual appearance and intense (18)F-FDG uptake in adulthood: report of two cases. (24667047)
2014
4
Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology. (24705787)
2014
5
Differentiation of Rebound and Lymphoid Thymic Hyperplasia from Anterior Mediastinal Tumors with Dual-Echo Chemical-Shift MR Imaging in Adulthood: Reliability of the Chemical-Shift Ratio and Signal Intensity Index. (25105246)
2014
6
Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia. (24556356)
2014
7
FDG PET/CT findings of thyrotoxicosis induced thymic hyperplasia associated to interferon. (23036823)
2013
8
Thymic hyperplasia in Graves' disease. (23869315)
2013
9
Thymic Hyperplasia Associated with Graves' Disease in a 10-year-old Boy. (23926397)
2011
10
Visual vignette. What is the diagnosis? Thymic hyperplasia associated with Graves disease. (21803716)
2011
11
Massive thymic hyperplasia presenting with respiratory insufficiency in a 2-year-old child. (20522860)
2010
12
Graves' disease and massive thymic hyperplasia. (20151833)
2010
13
Thymic hyperplasia and Graves disease: management of anterior mediastinal masses in patients with Graves disease. (19491074)
2009
14
Rebound thymic hyperplasia after pneumonectomy and chemotherapy for primary synovial sarcoma. (18728544)
2008
15
Benign thymic hyperplasia: an unexpected cause of respiratory distress during inhalatory induction of anesthesia. (19076582)
2008
16
Thymic hyperplasia in a child treated with growth hormone. (17141546)
2007
17
Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1. (17160015)
2007
18
True thymic hyperplasia associated with severe thymic cyst bleeding in a newborn: case report and review of the literature. (17870024)
2007
19
Thymic extension in the superior mediastinum in patients with thymic hyperplasia: potential cause of false-positive findings on 18F-FDG PET/CT. (17515398)
2007
20
True thymic hyperplasia associated with a unilocular thymic cyst: an unusual combination not previously reported. (16414543)
2006
21
Thymic hyperplasia: a cause of respiratory distress. (11715897)
2001
22
Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. (11682618)
2001
23
Thymic hyperplasia in a patient with Graves' disease. (11355328)
2001
24
Normalization of elevated CD4-/CD8- (double-negative) T cells after thymectomy parallels clinical remission in myasthenia gravis associated with thymic hyperplasia but not thymoma. (11026443)
2000
25
Cytologic diagnosis of true thymic hyperplasia by combined radiologic imaging and aspiration cytology: a case report including flow cytometric analysis. (11074650)
2000
26
Thymic hyperplasia after high-dose chemotherapy and autologous stem cell transplantation: incidence and significance in patients with breast cancer. (10541115)
1999
27
Induction of thymic hyperplasia and suppression of splenic T cells by lesioning of the anterior hypothalamus in aging Wistar rats. (9258247)
1997
28
Thymic hyperplasia in patients with Graves' disease. Identification of thyrotropin receptors in human thymus. (8941638)
1996
29
True massive thymic hyperplasia. (8689838)
1996
30
Macrophage subpopulations in the thymic hyperplasia of patients with myasthenia gravis. (8688498)
1995
31
Massive thymic hyperplasia: characterization of a rare mediastinal mass. (7877028)
1994
32
Focal thymic hyperplasia in an adult: report of a case. (8054781)
1994
33
Thymic hyperplasia in adults following chemotherapy for malignancy. (7688954)
1993
34
Interleukin-6 overproduction by cultured thymic epithelial cells from patients with myasthenia gravis is potentially involved in thymic hyperplasia. (8318672)
1993
35
Thymic hyperplasia with hemorrhage simulating recurrent Hodgkin disease after chemotherapy-induced complete remission. (1382826)
1992
36
Thymic hyperplasia masquerading as cardiomegaly: MRI validation. (1387113)
1992
37
Thymic hyperplasia after chemotherapy: two case reports and a literature review. (1940299)
1991
38
Film panel cases Society of Pediatric Radiology. Thymic hyperplasia. (2349023)
1990
39
Thymic hyperplasia. A clue to the diagnosis of hyperthyroidism. (2220714)
1990
40
Epithelial proliferation in thymic hyperplasia. An immunohistochemical study and correlation with the developing fetal thymus. (2705869)
1989
41
Massive thymic hyperplasia in infants. (3370726)
1988
42
Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen. (3118193)
1987
43
Thymic hyperplasia. I. True thymic hyperplasia. Review of the literature. (3560787)
1987
44
Thymic hyperplasia with occult ectopic ACTH syndrome. (3778080)
1986
45
Pathologic evaluation of thymic hyperplasia in myasthenia gravis and Lambert-Eaton myasthenic syndrome. (3755894)
1986
46
Diagnostic value of plain chest roentgenogram and CT scan findings in four cases of massive thymic hyperplasia. (3774392)
1986
47
Thymic hyperplasia following successful chemotherapy. A report of two cases and review of the literature. (4027888)
1985
48
Thymic hyperplasia in a case of Hodgkin's disease. (6604334)
1983
49
Thymic hyperplasia and neoplasia: a review of current concepts. (361541)
1978
50
Thymic hyperplasia in Graves' disease. (4099281)
1971

Variations for Thymic Hyperplasia

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Expression for genes affiliated with Thymic Hyperplasia

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Search GEO for disease gene expression data for Thymic Hyperplasia.

Pathways for genes affiliated with Thymic Hyperplasia

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Pathways related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6AGER, HMGB1
29.6AGER, HMGB1
3
Show member pathways
8.5CCL21, CCR7, CXCL13

GO Terms for genes affiliated with Thymic Hyperplasia

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Cellular components related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellGO:00056239.1CCL21, CXCL13
2cell surfaceGO:00099868.7AGER, CCR7, HMGB1, TSHR

Biological processes related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of dendritic cell differentiationGO:200120010.2AGER, HMGB1
2positive regulation of activated T cell proliferationGO:004210410.2AGER, HMGB1
3response to prostaglandin EGO:00346959.9CCL21, CCR7
4positive regulation of pseudopodium assemblyGO:00312749.9CCL21, CCR7
5positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.9CCL21, CCR7
6positive regulation of dendritic cell antigen processing and presentationGO:00026069.9CCL21, CCR7
7positive regulation of cell motilityGO:20001479.8CCL21, CCR7
8ruffle organizationGO:00315299.8CCL21, CCR7
9negative regulation of leukocyte apoptotic processGO:20001079.8CCL21, CCR7
10positive regulation of neutrophil chemotaxisGO:00900239.7CCL21, CCR7
11positive regulation of protein kinase activityGO:00458609.6CCL21, CCR7
12positive regulation of interleukin-12 productionGO:00327359.6AGER, CCR7, HMGB1
13positive regulation of actin filament polymerizationGO:00308389.5CCL21, CCR7
14establishment of T cell polarityGO:00017689.5CCL21, CCR7
15positive regulation of cell-matrix adhesionGO:00019549.5CCL21, CCR7
16positive regulation of JNK cascadeGO:00463309.2CCL21, CCR7, HMGB1
17positive regulation of filopodium assemblyGO:00514919.2CCL21, CCR7
18dendritic cell chemotaxisGO:00024079.2CCL21, CCR7, HMGB1
19release of sequestered calcium ion into cytosolGO:00512099.0CCL21, CCR7
20positive regulation of cytosolic calcium ion concentrationGO:00072048.9CCR7, CXCL13, HMGB1
21cell-cell signalingGO:00072678.9CCL21, CXCL13, TSHR
22positive regulation of ERK1 and ERK2 cascadeGO:00703748.9CCL21, CCR7, HMGB1
23activation of GTPase activityGO:00906308.5CCL21, CCR7, CXCL13
24inflammatory responseGO:00069547.9AGER, CCL21, CCR7, CXCL13, HMGB1

Molecular functions related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylserine bindingGO:000178610.0HMGB1, RPE65
2chemokine activityGO:00080099.0CCL21, CXCL13

Sources for Thymic Hyperplasia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet