MCID: THY043
MIFTS: 33

Thymic Hyperplasia malady

Rare diseases, Endocrine diseases categories

Aliases & Classifications for Thymic Hyperplasia

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Aliases & Descriptions for Thymic Hyperplasia:

Name: Thymic Hyperplasia 45
Hyperplasia of Thymus Gland 45
 
Thymus Hyperplasia 65


Classifications:



Summaries for Thymic Hyperplasia

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Wikipedia:68 Thymus hyperplasia (or thymic hyperplasia) refers to an enlargement (\"hyperplasia\") of the thymus. more...

MalaCards based summary: Thymic Hyperplasia, also known as hyperplasia of thymus gland, is related to graves' disease and myasthenia gravis. An important gene associated with Thymic Hyperplasia is AKTIP (AKT Interacting Protein), and among its related pathways are Advanced glycosylation endproduct receptor signaling and amb2 Integrin signaling. Affiliated tissues include thymus, t cells and thyroid, and related mouse phenotypes are behavior/neurological and cellular.

Related Diseases for Thymic Hyperplasia

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Graphical network of the top 20 diseases related to Thymic Hyperplasia:



Diseases related to thymic hyperplasia

Symptoms for Thymic Hyperplasia

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Drugs & Therapeutics for Thymic Hyperplasia

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Interventional clinical trials:

idNameStatusNCT IDPhase
1The Role of the Thymus in Myasthenia GravisActive, not recruitingNCT01102192

Search NIH Clinical Center for Thymic Hyperplasia

Genetic Tests for Thymic Hyperplasia

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Anatomical Context for Thymic Hyperplasia

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MalaCards organs/tissues related to Thymic Hyperplasia:

33
Thymus, T cells, Thyroid, Breast, Lung, Pituitary, Hypothalamus

Animal Models for Thymic Hyperplasia or affiliated genes

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MGI Mouse Phenotypes related to Thymic Hyperplasia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.6AGER, HMGB1, PTTG1, RPE65, TP63, TSHR
2MP:00053847.3AGER, CCR7, CXCL13, HMGB1, PTTG1, TP63
3MP:00053877.1AGER, CCR7, CXCL13, PTTG1, TP63, TSHR
4MP:00053766.9AGER, CCR7, HMGB1, PTTG1, RPE65, TP63

Publications for Thymic Hyperplasia

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Articles related to Thymic Hyperplasia:

(show top 50)    (show all 181)
idTitleAuthorsYear
1
Thymic hyperplasia and chylothorax. (25976649)
2015
2
A unilocular thymic cyst associated with true thymic hyperplasia: a challenging diagnosis especially in a child. (26445562)
2015
3
Chemical-shift MRI of rebound thymic hyperplasia with unusual appearance and intense (18)F-FDG uptake in adulthood: report of two cases. (24667047)
2014
4
Reactive thymic hyperplasia following chemotherapy for children with lymphoma: computed tomography may be able to provide valuable information to avoid over-treatment. (25079775)
2014
5
Severe thymic hyperplasia in a newborn calf associated with impaired T-cell differentiation. (23864259)
2013
6
Thymic Hyperplasia Associated with Graves' Disease in a 10-year-old Boy. (23926397)
2011
7
Thymic hyperplasia after lung transplantation imitating posttransplant lymphoproliferative disorder. (23213605)
2011
8
Visual vignette. What is the diagnosis? Thymic hyperplasia associated with Graves disease. (21803716)
2011
9
Thymic hyperplasia and Graves disease: management of anterior mediastinal masses in patients with Graves disease. (19491074)
2009
10
Benign thymic hyperplasia: an unexpected cause of respiratory distress during inhalatory induction of anesthesia. (19624373)
2009
11
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia. (19847900)
2009
12
Rebound thymic hyperplasia after pneumonectomy and chemotherapy for primary synovial sarcoma. (18728544)
2008
13
Thyrotoxic myopathy mimicking myasthenic syndrome associated with thymic hyperplasia. (18310980)
2008
14
Benign thymic hyperplasia: an unexpected cause of respiratory distress during inhalatory induction of anesthesia. (19076582)
2008
15
Thymic hyperplasia in a child treated with growth hormone. (17141546)
2007
16
False-positive iodine uptake in thymic hyperplasia on diagnostic I-123 whole-body scan after total thyroidectomy. (17242577)
2007
17
Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1. (17160015)
2007
18
An unusual cause of anterior mediastinal mass: thymic hyperplasia resulting from Graves disease. (16755190)
2006
19
A mediastinal mass: Graves' disease related thymic hyperplasia. (16314247)
2005
20
Thymic hyperplasia following successful treatment for nodular-sclerosing Hodgkin's disease. (14565667)
2003
21
Thymic hyperplasia and lung carcinomas in a line of mice transgenic for keratin 5-driven HPV16 E6/E7 oncogenes. (11781829)
2001
22
Thymic hyperplasia: a cause of respiratory distress. (11715897)
2001
23
Iodine-131 uptake in thymic hyperplasia with atypical computed tomographic features. (10795701)
2000
24
Normalization of elevated CD4-/CD8- (double-negative) T cells after thymectomy parallels clinical remission in myasthenia gravis associated with thymic hyperplasia but not thymoma. (11026443)
2000
25
Cytologic diagnosis of true thymic hyperplasia by combined radiologic imaging and aspiration cytology: a case report including flow cytometric analysis. (11074650)
2000
26
Pseudo-myasthenia gravis and thymic hyperplasia in Graves' disease. (10451743)
1999
27
Chromosomal proviral sequences of human immunodeficiency virus in multiple thymic cell types in a patient with acquired immunodeficiency syndrome and massive thymic hyperplasia. (9849994)
1998
28
True massive thymic hyperplasia. (9022591)
1997
29
Case report: true massive thymic hyperplasia. (8549051)
1996
30
Macrophage subpopulations in the thymic hyperplasia of patients with myasthenia gravis. (8688498)
1995
31
Massive thymic hyperplasia: characterization of a rare mediastinal mass. (7877028)
1994
32
Gallium-67 imaging for thymic hyperplasia in adults following chemotherapy. (8204178)
1993
33
Thymic hyperplasia in adults following chemotherapy for malignancy. (7688954)
1993
34
Massive thymic hyperplasia. (8494431)
1993
35
Thymic hyperplasia with hemorrhage simulating recurrent Hodgkin disease after chemotherapy-induced complete remission. (1382826)
1992
36
Thymic hyperplasia after chemotherapy: two case reports and a literature review. (1940299)
1991
37
Acromegaly and thymic hyperplasia: a case report. (2090673)
1990
38
A case of massive true thymic hyperplasia with non-Hodgkin's lymphoma. (2225994)
1990
39
Film panel cases Society of Pediatric Radiology. Thymic hyperplasia. (2349023)
1990
40
Thymic hyperplasia. A clue to the diagnosis of hyperthyroidism. (2220714)
1990
41
Thymic hyperplasia following chemotherapy of a testicular germ cell tumor. Immunohistological evidence for a simple rebound phenomenon. (2536289)
1989
42
Epithelial proliferation in thymic hyperplasia. An immunohistochemical study and correlation with the developing fetal thymus. (2705869)
1989
43
Thymic hyperplasia. II. Lymphofollicular hyperplasia of the thymus. An immunohistologic study. (2435953)
1987
44
Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen. (3118193)
1987
45
Mediastinal mass following chemotherapeutic treatment of Hodgkin's disease: recurrent tumor or thymic hyperplasia? (3440903)
1987
46
Thymic hyperplasia. I. True thymic hyperplasia. Review of the literature. (3560787)
1987
47
Thymic hyperplasia following successful chemotherapy. A report of two cases and review of the literature. (4027888)
1985
48
Thymic hyperplasia and neoplasia: a review of current concepts. (361541)
1978
49
The level of immunoglobulins in healthy children with thymic hyperplasia. (5370555)
1969
50
The level of immunoglobulins in sick children with thymic hyperplasia. (5370556)
1969

Variations for Thymic Hyperplasia

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Expression for genes affiliated with Thymic Hyperplasia

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Search GEO for disease gene expression data for Thymic Hyperplasia.

Pathways for genes affiliated with Thymic Hyperplasia

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Pathways related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5AGER, HMGB1
29.5AGER, HMGB1
3
Show member pathways
8.6CCL21, CCR7, CXCL13

GO Terms for genes affiliated with Thymic Hyperplasia

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Cellular components related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058297.1AGER, CCR7, CXCL13, HMGB1, PTTG1, TP63

Biological processes related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1establishment of T cell polarityGO:000176810.0CCL21, CCR7
2response to prostaglandin EGO:003469510.0CCL21, CCR7
3release of sequestered calcium ion into cytosolGO:005120910.0CCL21, CCR7
4positive regulation of filopodium assemblyGO:005149110.0CCL21, CCR7
5positive regulation of dendritic cell antigen processing and presentationGO:00026069.9CCL21, CCR7
6positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.9CCL21, CCR7
7positive regulation of pseudopodium assemblyGO:00312749.9CCL21, CCR7
8positive regulation of actin filament polymerizationGO:00308389.9CCL21, CCR7
9negative regulation of leukocyte apoptotic processGO:20001079.8CCL21, CCR7
10ruffle organizationGO:00315299.8CCL21, CCR7
11positive regulation of cell motilityGO:20001479.8CCL21, CCR7
12positive regulation of protein kinase activityGO:00458609.8CCL21, CCR7
13positive regulation of neutrophil chemotaxisGO:00900239.7CCL21, CCR7
14positive regulation of cell-matrix adhesionGO:00019549.4CCL21, CCR7
15dendritic cell chemotaxisGO:00024079.2CCL21, CCR7, HMGB1
16activation of GTPase activityGO:00906309.1CCL21, CCR7, CXCL13
17positive regulation of cytosolic calcium ion concentrationGO:00072049.1CCR7, CXCL13, HMGB1
18cell-cell signalingGO:00072679.1CCL21, CXCL13, TSHR
19positive regulation of JNK cascadeGO:00463309.0CCL21, CCR7, HMGB1
20positive regulation of ERK1 and ERK2 cascadeGO:00703748.9CCL21, CCR7, HMGB1
21apoptotic processGO:00069158.8AKTIP, HMGB1, TP63, XIAP
22chemokine-mediated signaling pathwayGO:00700988.8CCL21, CCR7, CXCL13
23inflammatory responseGO:00069547.9AGER, CCL21, CCR7, CXCL13, HMGB1

Molecular functions related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.0CCL21, CXCL13

Sources for Thymic Hyperplasia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet