MCID: THY043
MIFTS: 38

Thymic Hyperplasia

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Thymic Hyperplasia

MalaCards integrated aliases for Thymic Hyperplasia:

Name: Thymic Hyperplasia 49
Thymus Hyperplasia 69 28
Hyperplasia of Thymus Gland 49

Classifications:



External Ids:

UMLS 69 C0040115

Summaries for Thymic Hyperplasia

MalaCards based summary : Thymic Hyperplasia, also known as thymus hyperplasia, is related to myasthenia gravis with thymus hyperplasia and graves' disease. An important gene associated with Thymic Hyperplasia is AKTIP (AKT Interacting Protein), and among its related pathways/superpathways are Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions and amb2 Integrin signaling. Affiliated tissues include thymus, t cells and thyroid, and related phenotypes are cellular and hematopoietic system

Wikipedia : 72 Thymus hyperplasia (or thymic hyperplasia) refers to an enlargement (\"hyperplasia\") of the... more...

Related Diseases for Thymic Hyperplasia

Diseases related to Thymic Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 myasthenia gravis with thymus hyperplasia 12.3
2 graves' disease 10.3
3 myasthenia gravis congenital 10.3
4 myasthenia gravis 10.3
5 lymphoma 10.3
6 thymoma, familial 10.2
7 thymoma 10.2
8 mediastinitis 10.2
9 graves disease 1 10.1
10 thyroiditis 10.0
11 hyperthyroidism 10.0
12 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.0
13 germ cells tumors 9.9
14 testicular germ cell tumor 9.9
15 testicular germ cell tumor 1 9.9
16 breast cancer 9.8
17 thymic epithelial tumor 9.8
18 lambert-eaton myasthenic syndrome 9.8
19 hypokalemic periodic paralysis, type 1 9.8
20 conn's syndrome 9.8
21 goiter 9.8
22 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
23 lymphoma, hodgkin, classic 9.8
24 thyroid cancer 9.8
25 papillary thyroid microcarcinoma 9.8 TP63 TSHR
26 neuroblastoma 9.7
27 wilms tumor 6 9.7
28 pericarditis 9.7
29 lupus erythematosus 9.7
30 sjogren syndrome 9.7
31 b-cell lymphomas 9.7
32 acromegaly 9.7
33 encephalitis 9.7
34 autoimmune disease 9.7
35 asplenia, isolated congenital 9.7
36 burns 9.7
37 cervicitis 9.7
38 burkitt lymphoma 9.7
39 leukemia 9.7
40 lipomatosis 9.7
41 thrombocytopenia 9.7
42 myelitis 9.7
43 beckwith-wiedemann syndrome 9.7
44 transverse myelitis 9.7
45 hypercalcemia, infantile, 1 9.7
46 congenital myasthenic syndrome 9.7
47 myopathy - thyrotoxic 9.7
48 systemic lupus erythematosus 9.7
49 sarcoma, synovial 9.7
50 sialadenitis 9.7

Graphical network of the top 20 diseases related to Thymic Hyperplasia:



Diseases related to Thymic Hyperplasia

Symptoms & Phenotypes for Thymic Hyperplasia

MGI Mouse Phenotypes related to Thymic Hyperplasia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 AGER CCR7 CXCL13 PTTG1 TP63 TSHR
2 hematopoietic system MP:0005397 9.5 AGER CCR7 CXCL13 PTTG1 RPE65 TSHR
3 immune system MP:0005387 9.23 AGER CCR7 CXCL13 PTTG1 RPE65 TP63

Drugs & Therapeutics for Thymic Hyperplasia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Role of the Thymus in Myasthenia Gravis Active, not recruiting NCT01102192

Search NIH Clinical Center for Thymic Hyperplasia

Genetic Tests for Thymic Hyperplasia

Genetic tests related to Thymic Hyperplasia:

# Genetic test Affiliating Genes
1 Thymus Hyperplasia 28

Anatomical Context for Thymic Hyperplasia

MalaCards organs/tissues related to Thymic Hyperplasia:

38
Thymus, T Cells, Thyroid, Lung, Pituitary, Hypothalamus, Myeloid

Publications for Thymic Hyperplasia

Articles related to Thymic Hyperplasia:

(show top 50) (show all 195)
# Title Authors Year
1
Different neurologic outcomes of myasthenia gravis with thymic hyperplasia and thymoma after extended thymectomy: A single center experience. ( 29246632 )
2017
2
Thymic Hyperplasia Associated with Graves' Disease: Pathophysiology and Proposed Management Algorithm. ( 28578595 )
2017
3
Pathological Findings in Myasthenia Gravis Patients with Thymic Hyperplasia and Thymoma. ( 28299711 )
2017
4
Sudden unexpected death associated with Hashimoto's thyroiditis and thymic hyperplasia. ( 28124575 )
2017
5
Thymic hyperplasia associated with primary Sjogren's syndrome cured by thymectomy. ( 28275496 )
2017
6
Corrigendum to 'High rate of unnecessary thymectomy and its cause. Can computed tomography distinguish thymoma, lymphoma, thymic hyperplasia, and thymic cysts?' [EURR 84 (3) (2015) 524-533]. ( 28238381 )
2017
7
Thymic hyperplasia after chemotherapy in adults with mature B cell lymphoma and its influence on thymic output and CD4(+) T cells repopulation. ( 27467956 )
2016
8
Rebound Thymic Hyperplasia after Chemotherapy in Children with Lymphoma. ( 27364860 )
2016
9
Graves' Patient with Thymic Expression of Thyrotropin Receptors and Dynamic Changes in Thymic Hyperplasia Proportional to Graves' Disease Activity. ( 26996584 )
2016
10
Thymic Hyperplasia After Treatment of ACTH-Dependent Cushing's Syndrome Can Be Mistaken for a Thymic Epithelial Tumor. ( 27865872 )
2016
11
Thymic hyperplasia and its spontaneous resolution with treatment of Graves' hyperthyroidism. ( 27190120 )
2016
12
Myasthenia gravis accompanied by Graves' disease, thyrotoxic hypokalemic periodic paralysis and thymic hyperplasia. ( 27381127 )
2016
13
Rebound thymic hyperplasia following high dose chemotherapy and stem cell transplant in three neuroblastoma patients. ( 27663277 )
2016
14
Congenital myasthenic syndrome due to mutation in CHRNE gene with clinical worsening and thymic hyperplasia attributed to association with autoimmune-myasthenia gravis. ( 26363966 )
2015
15
Clinical Outcomes of Myasthenia Gravis with Thymoma and Thymic Hyperplasia Undergoing Extended Transsternal Thymectomy: A Single-Center Experience. ( 26713298 )
2015
16
High rate of unnecessary thymectomy and its cause. Can computed tomography distinguish thymoma, lymphoma, thymic hyperplasia, and thymic cysts? ( 25575742 )
2015
17
A unilocular thymic cyst associated with true thymic hyperplasia: a challenging diagnosis especially in a child. ( 26445562 )
2015
18
Thymic hyperplasia and chylothorax. ( 25976649 )
2015
19
Massive thymic hyperplasia in a neonate with Beckwith-Weidemann syndrome. ( 26364853 )
2015
20
Synchronous triple thymoma and true thymic hyperplasia simultaneously detected by (18)F FDG PET-CT. ( 25771094 )
2015
21
Diffusion-weighted MRI in a case of nonsuppressing rebound thymic hyperplasia on chemical-shift MRI. ( 25556605 )
2015
22
Usefulness of CT in differentiating lymphoid thymic hyperplasia from true thymic hyperplasia: added value of thymic measurements and CT attenuation. ( 25539267 )
2015
23
Reply to "Usefulness of CT in differentiating lymphoid thymic hyperplasia from true thymic hyperplasia: added value of thymic measurements and CT attenuation". ( 25539268 )
2015
24
An adolescent with Graves' disease and thymic hyperplasia. ( 24605862 )
2014
25
Rebound Thymic Hyperplasia Detected by (18)F-FDG PET/CT After Radioactive Iodine Ablation Therapy for Thyroid Cancer. ( 25065897 )
2014
26
Chemical-shift MRI of rebound thymic hyperplasia with unusual appearance and intense (18)F-FDG uptake in adulthood: report of two cases. ( 24667047 )
2014
27
Imaging of thymus in myasthenia gravis: from thymic hyperplasia to thymic tumor. ( 24581970 )
2014
28
Thymic hyperplasia in patients with Graves' disease. ( 25149085 )
2014
29
Differentiation of Rebound and Lymphoid Thymic Hyperplasia from Anterior Mediastinal Tumors with Dual-Echo Chemical-Shift MR Imaging in Adulthood: Reliability of the Chemical-Shift Ratio and Signal Intensity Index. ( 25105246 )
2014
30
Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia. ( 24556356 )
2014
31
Imaging characteristics of pathologically proven thymic hyperplasia: identifying features that can differentiate true from lymphoid hyperplasia. ( 24555583 )
2014
32
Reactive thymic hyperplasia following chemotherapy for children with lymphoma: computed tomography may be able to provide valuable information to avoid over-treatment. ( 25079775 )
2014
33
Anti NMDA receptor encephalitis associated with thymic hyperplasia: a case report. ( 25033868 )
2014
34
Thymic measurements in pathologically proven normal thymus and thymic hyperplasia: intraobserver and interobserver variabilities. ( 24809315 )
2014
35
Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology. ( 24705787 )
2014
36
Thymic hyperplasia following chemotherapy in adults with lymphoma: (18)F-FDG PET/CT findings and correlation with the T cell repopulation. ( 25407653 )
2014
37
Thymic hyperplasia in Graves' disease. ( 23869315 )
2013
38
FDG PET/CT findings of thyrotoxicosis induced thymic hyperplasia associated to interferon. ( 23036823 )
2013
39
Graves' disease and thymic hyperplasia. ( 24238061 )
2013
40
Severe thymic hyperplasia in a newborn calf associated with impaired T-cell differentiation. ( 23864259 )
2013
41
Hypokalemic periodic paralysis induced by thymic hyperplasia and relieved by thymectomy. ( 24061198 )
2013
42
Pericarditis, thymic hyperplasia, and Graves' thyrotoxicosis: case report and review of the literature. ( 23820368 )
2013
43
Thymic hyperplasia in a patient with Grave's disease. ( 22321290 )
2012
44
Thymic hyperplasia with lymphoepithelial sialadenitis (LESA)-like features: a clinicopathologic and immunohistochemical study of 4 cases. ( 23161715 )
2012
45
Visual vignette. What is the diagnosis? Thymic hyperplasia associated with Graves disease. ( 21803716 )
2011
46
Unusual thymic hyperplasia mimicking lipomatous tumor in an eight-year-old boy with concomitant pericardial lipomatosis and right facial hemihypertrophy. ( 21603297 )
2011
47
Lambert-Eaton myasthenic syndrome and follicular thymic hyperplasia in systemic lupus erythematosus. ( 21427136 )
2011
48
Thymic Hyperplasia Associated with Graves' Disease in a 10-year-old Boy. ( 23926397 )
2011
49
Thymic hyperplasia in Graves' disease. ( 22189747 )
2011
50
Thymic hyperplasia after lung transplantation imitating posttransplant lymphoproliferative disorder. ( 23213605 )
2011

Variations for Thymic Hyperplasia

Expression for Thymic Hyperplasia

Search GEO for disease gene expression data for Thymic Hyperplasia.

Pathways for Thymic Hyperplasia

Pathways related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.2 CCL21 CCR7 CXCL13
2 10.84 AGER HMGB1
3 9.74 AGER HMGB1

GO Terms for Thymic Hyperplasia

Cellular components related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 AGER CCR7 HMGB1 TSHR

Biological processes related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.8 AGER CXCL13 TSHR
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.75 CCR7 CXCL13 HMGB1
3 activation of GTPase activity GO:0090630 9.71 CCL21 CCR7 CXCL13
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.67 AGER CCL21 CCR7 HMGB1
5 chemokine-mediated signaling pathway GO:0070098 9.65 CCL21 CCR7 CXCL13
6 inflammatory response GO:0006954 9.65 AGER CCL21 CCR7 CXCL13 HMGB1
7 positive regulation of actin filament polymerization GO:0030838 9.62 CCL21 CCR7
8 release of sequestered calcium ion into cytosol GO:0051209 9.62 CCL21 CCR7
9 chemotaxis GO:0006935 9.62 CCL21 CCR7 CXCL13 HMGB1
10 positive regulation of neutrophil chemotaxis GO:0090023 9.61 CCL21 CCR7
11 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.61 CCL21 CCR7
12 positive regulation of filopodium assembly GO:0051491 9.6 CCL21 CCR7
13 positive regulation of activated T cell proliferation GO:0042104 9.59 AGER HMGB1
14 positive regulation of cell-matrix adhesion GO:0001954 9.58 CCL21 CCR7
15 ruffle organization GO:0031529 9.57 CCL21 CCR7
16 positive regulation of cell motility GO:2000147 9.56 CCL21 CCR7
17 positive regulation of pseudopodium assembly GO:0031274 9.55 CCL21 CCR7
18 response to prostaglandin E GO:0034695 9.52 CCL21 CCR7
19 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.51 CCL21 CCR7
20 negative regulation of dendritic cell apoptotic process GO:2000669 9.49 CCL21 CCR7
21 establishment of T cell polarity GO:0001768 9.46 CCL21 CCR7
22 positive regulation of dendritic cell differentiation GO:2001200 9.43 AGER HMGB1
23 negative regulation of leukocyte apoptotic process GO:2000107 9.4 CCL21 CCR7
24 positive regulation of interleukin-12 production GO:0032735 9.33 AGER CCR7 HMGB1
25 dendritic cell chemotaxis GO:0002407 9.13 CCL21 CCR7 HMGB1
26 positive regulation of JNK cascade GO:0046330 8.92 AGER CCL21 CCR7 HMGB1

Molecular functions related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL21 CXCL13
2 phosphatidylserine binding GO:0001786 9.16 HMGB1 RPE65
3 cysteine-type endopeptidase inhibitor activity GO:0004869 8.96 PTTG1 XIAP
4 cytokine activity GO:0005125 8.8 CCL21 CXCL13 HMGB1

Sources for Thymic Hyperplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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