MCID: THY043
MIFTS: 43

Thymic Hyperplasia malady

Rare diseases, Endocrine diseases categories
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Summaries for Thymic Hyperplasia

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33MalaCards
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MalaCards: Thymic Hyperplasia, also known as hyperplasia of thymus gland, is related to thyroiditis and breast cancer. An important gene associated with Thymic Hyperplasia is RPE65 (retinal pigment epithelium-specific protein 65kDa), and among its related pathways are Small cell lung cancer and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The compounds indole-3-carbinol and dutp have been mentioned in the context of this disorder. Affiliated tissues include thymus, t cells and lung, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Aliases & Classifications for Thymic Hyperplasia

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

thymic hyperplasia 43
hyperplasia of thymus gland 43
thymus hyperplasia 62


Related Diseases for Thymic Hyperplasia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Thymic Hyperplasia:



Diseases related to thymic hyperplasia

Symptoms for Thymic Hyperplasia

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Drugs & Therapeutics for Thymic Hyperplasia

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Thymic Hyperplasia

Search NIH Clinical Center for Thymic Hyperplasia

Genetic Tests for Thymic Hyperplasia

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Anatomical Context for Thymic Hyperplasia

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33MalaCards
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MalaCards organs/tissues related to Thymic Hyperplasia:

33
Thymus, T cells, Lung, Thyroid, Breast, Myeloid, Hypothalamus, Pituitary

Animal Models for Thymic Hyperplasia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Thymic Hyperplasia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.0PTTG1, TP63, TSHR, CCND1, XIAP
2MP:00053797.9PTTG1, TP63, POMC, TSHR, CCND1, XIAP
3MP:00053977.7PTTG1, POMC, TSHR, CXCL13, CCND1, XIAP
4MP:00107687.7XIAP, CCND1, TSHR, POMC, TP63, PTTG1
5MP:00053867.6XIAP, PTTG1, TP63, POMC, TSHR, CCND1
6MP:00053847.6PTTG1, TP63, POMC, CXCL13, CCND1, XIAP
7MP:00053767.6PTTG1, TP63, POMC, TSHR, CCND1, RPE65
8MP:00053787.4PTTG1, TP63, POMC, TSHR, CCND1, XIAP
9MP:00053877.4PTTG1, TP63, POMC, TSHR, CXCL13, CCND1

Publications for Thymic Hyperplasia

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52PubMed
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Articles related to Thymic Hyperplasia:

(show top 50)    (show all 157)
idTitleAuthorsYear
1
Severe thymic hyperplasia in a newborn calf associated with impaired T-cell differentiation. (23864259)
2013
2
FDG PET/CT findings of thyrotoxicosis induced thymic hyperplasia associated to interferon. (23036823)
2013
3
Thymic Hyperplasia Associated with Graves' Disease in a 10-year-old Boy. (23926397)
2011
4
Thymic hyperplasia after lung transplantation imitating posttransplant lymphoproliferative disorder. (23213605)
2011
5
Visual vignette. What is the diagnosis? Thymic hyperplasia associated with Graves disease. (21803716)
2011
6
Massive thymic hyperplasia presenting with respiratory insufficiency in a 2-year-old child. (20522860)
2010
7
Thymic hyperplasia and Graves disease: management of anterior mediastinal masses in patients with Graves disease. (19491074)
2009
8
Benign thymic hyperplasia: an unexpected cause of respiratory distress during inhalatory induction of anesthesia. (19624373)
2009
9
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia. (19847900)
2009
10
Rebound thymic hyperplasia after pneumonectomy and chemotherapy for primary synovial sarcoma. (18728544)
2008
11
Thyrotoxic myopathy mimicking myasthenic syndrome associated with thymic hyperplasia. (18310980)
2008
12
Benign thymic hyperplasia: an unexpected cause of respiratory distress during inhalatory induction of anesthesia. (19076582)
2008
13
Thymic hyperplasia in a child treated with growth hormone. (17141546)
2007
14
False-positive iodine uptake in thymic hyperplasia on diagnostic I-123 whole-body scan after total thyroidectomy. (17242577)
2007
15
Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1. (17160015)
2007
16
An unusual cause of anterior mediastinal mass: thymic hyperplasia resulting from Graves disease. (16755190)
2006
17
A mediastinal mass: Graves' disease related thymic hyperplasia. (16314247)
2005
18
Thymic hyperplasia following successful treatment for nodular-sclerosing Hodgkin's disease. (14565667)
2003
19
Thymic hyperplasia and lung carcinomas in a line of mice transgenic for keratin 5-driven HPV16 E6/E7 oncogenes. (11781829)
2001
20
Thymic hyperplasia: a cause of respiratory distress. (11715897)
2001
21
Iodine-131 uptake in thymic hyperplasia with atypical computed tomographic features. (10795701)
2000
22
Normalization of elevated CD4-/CD8- (double-negative) T cells after thymectomy parallels clinical remission in myasthenia gravis associated with thymic hyperplasia but not thymoma. (11026443)
2000
23
Cytologic diagnosis of true thymic hyperplasia by combined radiologic imaging and aspiration cytology: a case report including flow cytometric analysis. (11074650)
2000
24
Pseudo-myasthenia gravis and thymic hyperplasia in Graves' disease. (10451743)
1999
25
Chromosomal proviral sequences of human immunodeficiency virus in multiple thymic cell types in a patient with acquired immunodeficiency syndrome and massive thymic hyperplasia. (9849994)
1998
26
True massive thymic hyperplasia. (9022591)
1997
27
Induction of thymic hyperplasia and suppression of splenic T cells by lesioning of the anterior hypothalamus in aging Wistar rats. (9258247)
1997
28
Case report: true massive thymic hyperplasia. (8549051)
1996
29
Macrophage subpopulations in the thymic hyperplasia of patients with myasthenia gravis. (8688498)
1995
30
Massive thymic hyperplasia: characterization of a rare mediastinal mass. (7877028)
1994
31
Gallium-67 imaging for thymic hyperplasia in adults following chemotherapy. (8204178)
1993
32
Thymic hyperplasia in adults following chemotherapy for malignancy. (7688954)
1993
33
Massive thymic hyperplasia. (8494431)
1993
34
Thymic hyperplasia with hemorrhage simulating recurrent Hodgkin disease after chemotherapy-induced complete remission. (1382826)
1992
35
Thymic hyperplasia after chemotherapy: two case reports and a literature review. (1940299)
1991
36
Acromegaly and thymic hyperplasia: a case report. (2090673)
1990
37
A case of massive true thymic hyperplasia with non-Hodgkin's lymphoma. (2225994)
1990
38
Film panel cases Society of Pediatric Radiology. Thymic hyperplasia. (2349023)
1990
39
Thymic hyperplasia. A clue to the diagnosis of hyperthyroidism. (2220714)
1990
40
Thymic hyperplasia following chemotherapy of a testicular germ cell tumor. Immunohistological evidence for a simple rebound phenomenon. (2536289)
1989
41
Epithelial proliferation in thymic hyperplasia. An immunohistochemical study and correlation with the developing fetal thymus. (2705869)
1989
42
Thymic hyperplasia. II. Lymphofollicular hyperplasia of the thymus. An immunohistologic study. (2435953)
1987
43
Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen. (3118193)
1987
44
Mediastinal mass following chemotherapeutic treatment of Hodgkin's disease: recurrent tumor or thymic hyperplasia? (3440903)
1987
45
Thymic hyperplasia. I. True thymic hyperplasia. Review of the literature. (3560787)
1987
46
Thymic hyperplasia following successful chemotherapy. A report of two cases and review of the literature. (4027888)
1985
47
Computerized tomography and ultrasonographic findings in massive thymic hyperplasia. Case discussion and review of current concepts. (3881205)
1985
48
Thymic hyperplasia and neoplasia: a review of current concepts. (361541)
1978
49
The level of immunoglobulins in healthy children with thymic hyperplasia. (5370555)
1969
50
The level of immunoglobulins in sick children with thymic hyperplasia. (5370556)
1969

Variations for Thymic Hyperplasia

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Expression for genes affiliated with Thymic Hyperplasia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thymic Hyperplasia

Search GEO for disease gene expression data for Thymic Hyperplasia.

Pathways for genes affiliated with Thymic Hyperplasia

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50PathCards, 30KEGG, 54R&D Systems, 55Reactome, 53QIAGEN, 60Thomson Reuters, 38NCBI BioSystems Database
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Pathways related to Thymic Hyperplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CCND1, XIAP
2
Show member pathways
9.3CCL21, CXCL13
3
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling60
9.3CCL21, CXCL13
48.9PTTG1, CCND1, XIAP
5
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.9XIAP, CCND1, PTTG1
6
Show member pathways
8.6CCL21, CXCL13, TSHR, POMC
7
Show member pathways
7.9RPE65, POMC, TSHR, CXCL13, CCND1, CCL21

Compounds for genes affiliated with Thymic Hyperplasia

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45Novoseek, 11DrugBank, 3BitterDB, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Thymic Hyperplasia according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1indole-3-carbinol4510.0XIAP, CCND1
2dutp4510.0CCND1, XIAP
3sulindac45 1111.0CCND1, XIAP
4methimazole45 3 1112.0POMC, TSHR
5noxa4510.0XIAP, TP63
6suberoylanilide hydroxamic acid459.9XIAP, CCND1
7roscovitine459.9XIAP, CCND1
8flavopiridol45 1110.9CCND1, XIAP
9hematoxylin459.8RPE65, TP63
10rottlerin459.8CCND1, XIAP
11triiodothyronine459.8TSHR, POMC
12vincristine45 51 1111.8XIAP, CCND1, POMC
13teck459.7CCL21, CXCL13
14bortezomib45 51 1111.6CCND1, XIAP
15doxorubicin45 51 1111.5TP63, CCND1, XIAP
16estradiol45 24 1111.4XIAP, CCND1, TSHR, POMC
17cisplatin45 51 61 1112.3XIAP, CCND1, TP63
18agar459.2XIAP, CCND1, PTTG1
19ribonucleic acid459.2PTTG1, POMC, TSHR
20progesterone45 29 61 24 1113.2TP63, POMC, TSHR, CCND1
21retinoic acid45 2410.0TP63, TSHR, CCND1, RPE65, XIAP
22paraffin458.9TP63, POMC, TSHR, CCND1, XIAP
23ag 1478458.9CCND1, PTTG1
24phosphatidylinositol458.9PTTG1, TSHR, CCND1, XIAP
25thymidine45 249.8PTTG1, TP63, TSHR, CCND1
26estrogen458.4PTTG1, TP63, POMC, TSHR, CCND1
27vegf457.8XIAP, RPE65, CCND1, TSHR, POMC, TP63
28calcium45 51 24 1110.7PTTG1, TP63, TSHR, CXCL13, CCL21, XIAP

GO Terms for genes affiliated with Thymic Hyperplasia

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16Gene Ontology
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Biological processes related to Thymic Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:0101659.6CCND1, TP63
2mitotic G1 DNA damage checkpointGO:0315719.3CCND1, TP63
3cell-cell signalingGO:0072678.5CCL21, CXCL13, TSHR, POMC

Molecular functions related to Thymic Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.3CCL21, CXCL13

Products for genes affiliated with Thymic Hyperplasia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thymic Hyperplasia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet