MCID: THY043
MIFTS: 32

Thymic Hyperplasia malady

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Thymic Hyperplasia

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Aliases & Descriptions for Thymic Hyperplasia:

Name: Thymic Hyperplasia 48
Hyperplasia of Thymus Gland 48
 
Thymus Hyperplasia 68

Classifications:



Summaries for Thymic Hyperplasia

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MalaCards based summary: Thymic Hyperplasia, also known as hyperplasia of thymus gland, is related to graves' disease and myasthenia gravis. An important gene associated with Thymic Hyperplasia is AKTIP (AKT Interacting Protein), and among its related pathways are Advanced glycosylation endproduct receptor signaling and amb2 Integrin signaling. Affiliated tissues include thymus, t cells and thyroid, and related mouse phenotypes are vision/eye and hematopoietic system.

Related Diseases for Thymic Hyperplasia

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Graphical network of the top 20 diseases related to Thymic Hyperplasia:



Diseases related to thymic hyperplasia

Symptoms & Phenotypes for Thymic Hyperplasia

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MGI Mouse Phenotypes related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.8AKTIP, CCR7, RPE65, TP63, TSHR
2MP:00053978.0AGER, CCR7, CXCL13, PTTG1, RPE65, TSHR
3MP:00053877.6AGER, CCR7, CXCL13, PTTG1, RPE65, TP63

Drugs & Therapeutics for Thymic Hyperplasia

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Interventional clinical trials:

idNameStatusNCT IDPhase
1The Role of the Thymus in Myasthenia GravisActive, not recruitingNCT01102192

Search NIH Clinical Center for Thymic Hyperplasia

Genetic Tests for Thymic Hyperplasia

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Anatomical Context for Thymic Hyperplasia

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MalaCards organs/tissues related to Thymic Hyperplasia:

36
Thymus, T cells, Thyroid, Lung, Pituitary, Hypothalamus, Myeloid

Publications for Thymic Hyperplasia

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Articles related to Thymic Hyperplasia:

(show top 50)    (show all 189)
idTitleAuthorsYear
1
Thymic hyperplasia after chemotherapy in adults with mature B cell lymphoma and its influence on thymic output and CD4(+) T cells repopulation. (27467956)
2016
2
Rebound thymic hyperplasia following high dose chemotherapy and stem cell transplant in three neuroblastoma patients. (27663277)
2016
3
Thymic Hyperplasia After Treatment of ACTH-Dependent Cushing's Syndrome Can Be Mistaken for a Thymic Epithelial Tumor. (27865872)
2016
4
Graves' Patient with Thymic Expression of Thyrotropin Receptors and Dynamic Changes in Thymic Hyperplasia Proportional to Graves' Disease Activity. (26996584)
2016
5
Myasthenia gravis accompanied by Graves' disease, thyrotoxic hypokalemic periodic paralysis and thymic hyperplasia. (27381127)
2016
6
Thymic hyperplasia and its spontaneous resolution with treatment of Graves' hyperthyroidism. (27190120)
2016
7
Rebound Thymic Hyperplasia after Chemotherapy in Children with Lymphoma. (27364860)
2016
8
Thymic hyperplasia and chylothorax. (25976649)
2015
9
Massive thymic hyperplasia in a neonate with Beckwith-Weidemann syndrome. (26364853)
2015
10
Diffusion-weighted MRI in a case of nonsuppressing rebound thymic hyperplasia on chemical-shift MRI. (25556605)
2015
11
Clinical Outcomes of Myasthenia Gravis with Thymoma and Thymic Hyperplasia Undergoing Extended Transsternal Thymectomy: A Single-Center Experience. (26713298)
2015
12
A unilocular thymic cyst associated with true thymic hyperplasia: a challenging diagnosis especially in a child. (26445562)
2015
13
Usefulness of CT in differentiating lymphoid thymic hyperplasia from true thymic hyperplasia: added value of thymic measurements and CT attenuation. (25539267)
2015
14
Synchronous triple thymoma and true thymic hyperplasia simultaneously detected by (18)F FDG PET-CT. (25771094)
2015
15
Reply to "Usefulness of CT in differentiating lymphoid thymic hyperplasia from true thymic hyperplasia: added value of thymic measurements and CT attenuation". (25539268)
2015
16
Congenital myasthenic syndrome due to mutation in CHRNE gene with clinical worsening and thymic hyperplasia attributed to association with autoimmune-myasthenia gravis. (26363966)
2015
17
High rate of unnecessary thymectomy and its cause. Can computed tomography distinguish thymoma, lymphoma, thymic hyperplasia, and thymic cysts? (25575742)
2015
18
Chemical-shift MRI of rebound thymic hyperplasia with unusual appearance and intense (18)F-FDG uptake in adulthood: report of two cases. (24667047)
2014
19
Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology. (24705787)
2014
20
Differentiation of Rebound and Lymphoid Thymic Hyperplasia from Anterior Mediastinal Tumors with Dual-Echo Chemical-Shift MR Imaging in Adulthood: Reliability of the Chemical-Shift Ratio and Signal Intensity Index. (25105246)
2014
21
Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia. (24556356)
2014
22
Thymic measurements in pathologically proven normal thymus and thymic hyperplasia: intraobserver and interobserver variabilities. (24809315)
2014
23
An adolescent with Graves' disease and thymic hyperplasia. (24605862)
2014
24
Anti NMDA receptor encephalitis associated with thymic hyperplasia: a case report. (25033868)
2014
25
Thymic hyperplasia following chemotherapy in adults with lymphoma: (18)F-FDG PET/CT findings and correlation with the T cell repopulation. (25407653)
2014
26
Thymic hyperplasia in patients with Graves' disease. (25149085)
2014
27
Reactive thymic hyperplasia following chemotherapy for children with lymphoma: computed tomography may be able to provide valuable information to avoid over-treatment. (25079775)
2014
28
Imaging of thymus in myasthenia gravis: from thymic hyperplasia to thymic tumor. (24581970)
2014
29
Imaging characteristics of pathologically proven thymic hyperplasia: identifying features that can differentiate true from lymphoid hyperplasia. (24555583)
2014
30
Rebound Thymic Hyperplasia Detected by (18)F-FDG PET/CT After Radioactive Iodine Ablation Therapy for Thyroid Cancer. (25065897)
2014
31
FDG PET/CT findings of thyrotoxicosis induced thymic hyperplasia associated to interferon. (23036823)
2013
32
Thymic hyperplasia in Graves' disease. (23869315)
2013
33
Severe thymic hyperplasia in a newborn calf associated with impaired T-cell differentiation. (23864259)
2013
34
Hypokalemic periodic paralysis induced by thymic hyperplasia and relieved by thymectomy. (24061198)
2013
35
Pericarditis, thymic hyperplasia, and Graves' thyrotoxicosis: case report and review of the literature. (23820368)
2013
36
Graves' disease and thymic hyperplasia. (24238061)
2013
37
Thymic hyperplasia with lymphoepithelial sialadenitis (LESA)-like features: a clinicopathologic and immunohistochemical study of 4 cases. (23161715)
2012
38
Thymic hyperplasia in a patient with Grave's disease. (22321290)
2012
39
Thymic Hyperplasia Associated with Graves' Disease in a 10-year-old Boy. (23926397)
2011
40
Visual vignette. What is the diagnosis? Thymic hyperplasia associated with Graves disease. (21803716)
2011
41
Unusual thymic hyperplasia mimicking lipomatous tumor in an eight-year-old boy with concomitant pericardial lipomatosis and right facial hemihypertrophy. (21603297)
2011
42
Thymic hyperplasia in Graves' disease. (22189747)
2011
43
Thymic hyperplasia after lung transplantation imitating posttransplant lymphoproliferative disorder. (23213605)
2011
44
Lambert-Eaton myasthenic syndrome and follicular thymic hyperplasia in systemic lupus erythematosus. (21427136)
2011
45
Massive thymic hyperplasia presenting with respiratory insufficiency in a 2-year-old child. (20522860)
2010
46
Graves' disease and massive thymic hyperplasia. (20151833)
2010
47
True thymic hyperplasia in an infant. (20713225)
2010
48
Our experience in thymic hyperplasia using 67Ga-citrate, 111In-pentetreotide and 201Tl-chloride. (20505931)
2010
49
An adolescent with a mediastinal mass, diagnosed with Graves disease and thymic hyperplasia. (20100762)
2010
50
Graves' disease and thymic hyperplasia: the relationship of thymic volume to thyroid function. (20718680)
2010

Variations for Thymic Hyperplasia

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Expression for genes affiliated with Thymic Hyperplasia

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Search GEO for disease gene expression data for Thymic Hyperplasia.

Pathways for genes affiliated with Thymic Hyperplasia

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Pathways related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7AGER, HMGB1
29.7AGER, HMGB1
3
Show member pathways
8.9CCL21, CCR7, CXCL13

GO Terms for genes affiliated with Thymic Hyperplasia

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Cellular components related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellGO:000562310.0CCL21, CXCL13
2cell surfaceGO:00099868.9AGER, CCR7, HMGB1, TSHR

Biological processes related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of activated T cell proliferationGO:004210410.4AGER, HMGB1
2positive regulation of dendritic cell differentiationGO:200120010.4AGER, HMGB1
3establishment of T cell polarityGO:000176810.2CCL21, CCR7
4negative regulation of leukocyte apoptotic processGO:200010710.1CCL21, CCR7
5positive regulation of actin filament polymerizationGO:003083810.1CCL21, CCR7
6positive regulation of cell motilityGO:200014710.1CCL21, CCR7
7positive regulation of cell-matrix adhesionGO:000195410.1CCL21, CCR7
8positive regulation of dendritic cell antigen processing and presentationGO:000260610.1CCL21, CCR7
9positive regulation of filopodium assemblyGO:005149110.1CCL21, CCR7
10positive regulation of neutrophil chemotaxisGO:009002310.0CCL21, CCR7
11positive regulation of phosphatidylinositol 3-kinase activityGO:004355210.0CCL21, CCR7
12positive regulation of protein kinase activityGO:00458609.9CCL21, CCR7
13positive regulation of pseudopodium assemblyGO:00312749.9CCL21, CCR7
14positive regulation of interleukin-12 productionGO:00327359.9AGER, CCR7, HMGB1
15release of sequestered calcium ion into cytosolGO:00512099.8CCL21, CCR7
16positive regulation of cytosolic calcium ion concentrationGO:00072049.7CCR7, CXCL13, HMGB1
17response to prostaglandin EGO:00346959.7CCL21, CCR7
18dendritic cell chemotaxisGO:00024079.7CCL21, CCR7, HMGB1
19cell-cell signalingGO:00072679.7CCL21, CXCL13, TSHR
20activation of GTPase activityGO:00906309.6CCL21, CCR7, CXCL13
21positive regulation of ERK1 and ERK2 cascadeGO:00703749.6CCL21, CCR7, HMGB1
22positive regulation of JNK cascadeGO:00463309.6CCL21, CCR7, HMGB1
23ruffle organizationGO:00315299.4CCL21, CCR7
24inflammatory responseGO:00069548.8AGER, CCL21, CCR7, CXCL13, HMGB1

Molecular functions related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.8CCL21, CXCL13
2phosphatidylserine bindingGO:00017869.7HMGB1, RPE65

Sources for Thymic Hyperplasia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet