MCID: THY043
MIFTS: 38

Thymic Hyperplasia malady

Endocrine category

Summaries for Thymic Hyperplasia

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33MalaCards
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MalaCards: Thymic Hyperplasia, also known as hyperplasia of thymus gland, is related to thymoma and thyroid cancer. An important gene associated with Thymic Hyperplasia is RPE65 (retinal pigment epithelium-specific protein 65kDa), and among its related pathways are HTLV-I infection and Class A/1 (Rhodopsin-like receptors). The compounds noxa and indole-3-carbinol have been mentioned in the context of this disorder. Affiliated tissues include lung, thymus and thyroid, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Thymic Hyperplasia

Sources:
43NIH Rare Diseases, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

thymic hyperplasia 43
hyperplasia of thymus gland 43
thymus hyperplasia 61


Related Diseases for Thymic Hyperplasia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Thymic Hyperplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma30.6TP63
2thyroid cancer30.0TP63, TSHR
3graves' disease10.7
4thyrotoxicosis10.5
5testicular germ cell tumor10.3
6myasthenia gravis with thymus hyperplasia10.2
7lambert-eaton myasthenic syndrome10.2
8lambert syndrome10.2
9mass syndrome10.2
10congenital diaphragmatic hernia10.1
11pierre robin sequence10.1
12burns10.0
13nodular goiter10.0
14pituitary hypoplasia10.0
15myelitis10.0
16acute myeloid leukemia10.0
17cushing's syndrome10.0
18systemic lupus erythematosus10.0
19acromegaly10.0
20beckwith-wiedemann syndrome10.0
21acquired immunodeficiency syndrome10.0
22sialadenitis10.0
23hypercalcemia10.0
24adult lymphoma10.0
25hypokalemic periodic paralysis10.0
26acute leukemia10.0
27synovial sarcoma10.0
28thrombocytopenia10.0
29thymic carcinoma10.0
30wilms tumor10.0
31transverse myelitis10.0
32myopathy - thyrotoxic10.0
33zimmermann-laband syndrome10.0
34germ cell tumors10.0
35hemihypertrophy10.0
36proteus syndrome, somatic10.0
37craniopharyngioma10.0POMC
38nelson syndrome10.0POMC
39adrenal carcinoma10.0POMC
40skin cancer10.0POMC
41endometrial carcinoma10.0CCND1
42esophageal cancer10.0CCND1
43prolactinoma10.0PTTG1, POMC
44mitral valve prolapse10.0TSHR
45pituitary tumors10.0POMC, PTTG1
46follicular thyroid carcinoma10.0PTTG1, TSHR
47thyroiditis10.0TSHR, POMC
48lymphoma, malt, somatic10.0CXCL13, CCND1
49hypersensitivity reaction type ii disease10.0TSHR, POMC
50ovarian cancer10.0XIAP, CCND1

Graphical network of the top 20 diseases related to Thymic Hyperplasia:



Diseases related to thymic hyperplasia

Clinical Features for Thymic Hyperplasia

Drugs & Therapeutics for Thymic Hyperplasia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Thymic Hyperplasia

Drug clinical trials:

Search ClinicalTrials for Thymic Hyperplasia

Search NIH Clinical Center for Thymic Hyperplasia

Search CenterWatch for Thymic Hyperplasia

Genetic Tests for Thymic Hyperplasia

Anatomical Context for Thymic Hyperplasia

Sources:
33MalaCards
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MalaCards organs/tissues related to Thymic Hyperplasia:

33
Lung, Thymus, Thyroid, Breast, Myeloid, T cells, B cells, Hypothalamus, Fetal lung, Fetal thyroid, Pituitary

Animal Models for Thymic Hyperplasia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Thymic Hyperplasia

Sources:
51PubMed
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Articles related to Thymic Hyperplasia:

(show top 50)    (show all 166)
idTitleAuthorsYear
1
Severe thymic hyperplasia in a newborn calf associated with impaired T-cell differentiation. (23864259)
2013
2
Thymic hyperplasia in Graves' disease. (23869315)
2013
3
Carcinoid tumor arising in a thymic bronchogenic cyst associated with thymic follicular hyperplasia. (22192804)
2012
4
Micronodular thymic carcinoma with lymphoid hyperplasia: a clinicopathological and immunohistochemical study of five cases. (22388764)
2012
5
Lambert-Eaton myasthenic syndrome and follicular thymic hyperplasia in systemic lupus erythematosus. (21427136)
2011
6
Unusual thymic hyperplasia mimicking lipomatous tumor in an eight-year-old boy with concomitant pericardial lipomatosis and right facial hemihypertrophy. (21603297)
2011
7
True thymic hyperplasia associated with thymic hemorrhage in an adult patient. (19640657)
2010
8
True thymic hyperplasia in an infant. (20713225)
2010
9
An adolescent with a mediastinal mass, diagnosed with Graves disease and thymic hyperplasia. (20100762)
2010
10
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia. (19847900)
2009
11
Primary mediastinal Hodgkin lymphoma and rebound thymic hyperplasia: differentiation with chemical-shift magnetic resonance imaging after treatment. (19521748)
2009
12
Rebound thymic hyperplasia after pneumonectomy and chemotherapy for primary synovial sarcoma. (18728544)
2008
13
Thyrotoxic myopathy mimicking myasthenic syndrome associated with thymic hyperplasia. (18310980)
2008
14
Thymic hyperplasia in a patient with recurrent transverse myelitis with clinical resolution after thymectomy. (18281453)
2008
15
False-positive iodine uptake in thymic hyperplasia on diagnostic I-123 whole-body scan after total thyroidectomy. (17242577)
2007
16
Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1. (17160015)
2007
17
Simultaneous diagnosis of CD3+ T-cell large granular lymphocyte leukaemia and true thymic hyperplasia. (17137624)
2007
18
An unusual cause of anterior mediastinal mass: thymic hyperplasia resulting from Graves disease. (16755190)
2006
19
True thymic hyperplasia associated with a unilocular thymic cyst: an unusual combination not previously reported. (16414543)
2006
20
A mediastinal mass: Graves' disease related thymic hyperplasia. (16314247)
2005
21
Thymic hyperplasia in thyroid cancer patients. (15729115)
2005
22
Massive benign thymic hyperplasia in a six-month-old girl: case report. (12953831)
2003
23
Thymic hyperplasia presenting as anterior mediastinal mass in 2 patients with Graves disease. (12005000)
2002
24
Thymic hyperplasia: a cause of respiratory distress. (11715897)
2001
25
Thymic hyperplasia as a source of ectopic ACTH production. (11075732)
2000
26
Chromosomal proviral sequences of human immunodeficiency virus in multiple thymic cell types in a patient with acquired immunodeficiency syndrome and massive thymic hyperplasia. (9849994)
1998
27
Toxic nodular goiter and thymic hyperplasia in an adult. Case report. (9557476)
1997
28
Thymic hyperplasia in patients with Graves' disease. Identification of thyrotropin receptors in human thymus. (8941638)
1996
29
Gonadal atrophy as a cause of thymic hyperplasia after chemotherapy. (8826874)
1996
30
Massive thymic hyperplasia: characterization of a rare mediastinal mass. (7877028)
1994
31
Thymic hyperplasia in newly diagnosed testicular germ cell tumors. (7933189)
1994
32
Thymic hyperplasia in adults following chemotherapy for malignancy. (7688954)
1993
33
Gallium-avid thymic hyperplasia in an adult after chemotherapy for Hodgkin disease. (8334644)
1993
34
Thymic hyperplasia masquerading as cardiomegaly: MRI validation. (1387113)
1992
35
Thymic hyperplasia associated with Hodgkin disease and thyrotoxicosis. (1525776)
1992
36
Paraneoplastic hypercalcemia in thymic hyperplasia. (1524047)
1992
37
In vitro interleukin-1 (IL-1) production in thymic hyperplasia and thymoma from patients with myasthenia gravis. (1795043)
1991
38
Rebound thymic hyperplasia five years after chemotherapy for Wilms' tumor. (1667681)
1991
39
Thymic hyperplasia following chemotherapy of a testicular germ cell tumor. Immunohistological evidence for a simple rebound phenomenon. (2536289)
1989
40
True thymic hyperplasia: an unrecognised cause of cardiac murmur? (3250049)
1988-1989
41
Myoid cell differentiation in true thymic hyperplasia and lymphoid hyperplasia. (3178429)
1988
42
Mediastinal mass following chemotherapeutic treatment of Hodgkin's disease: recurrent tumor or thymic hyperplasia? (3440903)
1987
43
Tumor-like massive thymic hyperplasia in childhood: a possible defect of T-cell maturation, histological and cytoenzymatic studies of three cases. (3489303)
1986
44
Thymic hyperplasia following successful chemotherapy. A report of two cases and review of the literature. (4027888)
1985
45
Massive thymic hyperplasia in an infant with Beckwith-Wiedemann syndrome. (3838440)
1985
46
Thymic hyperplasia in a case of Hodgkin's disease. (6604334)
1983
47
The CT detection of thymic hyperplasia in association with thyrotoxicosis: case report. (6641206)
1983
48
Thymic hyperplasia with massive enlargement: report of two cases with review of diagnostic criteria. (7218839)
1981
49
Immunological aspects of sarcoidosis associated with true thymic hyperplasia. (7457289)
1980
50
Comparison of thymic hyperplasia in myasthenia gravis and exophthalmic goiter. (18123746)
1948

Genetic Variations for Thymic Hyperplasia

Expression for genes affiliated with Thymic Hyperplasia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thymic Hyperplasia

Search GEO for disease gene expression data for Thymic Hyperplasia.

Pathways for genes affiliated with Thymic Hyperplasia

Sources:
30KEGG, 54Reactome
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Pathways related to Thymic Hyperplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1PTTG1, XIAP, CCND1
2
Hide members
8.4TSHR, CXCL13, POMC, CCL21

Compounds for genes affiliated with Thymic Hyperplasia

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 2BitterDB, 24HMDB, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Thymic Hyperplasia according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1noxa459.9TP63, XIAP
2indole-3-carbinol459.8CCND1, XIAP
3estrogen459.8TSHR, PTTG1
4sulindac45 1110.7CCND1, XIAP
5suberoylanilide hydroxamic acid459.7XIAP, CCND1
6vincristine45 50 1111.7CCND1, XIAP, POMC
7dutp459.6CCND1, XIAP
8methimazole45 2 1111.5POMC, TSHR
9teck459.4CCL21, CXCL13
10estradiol45 11 2411.3TSHR, POMC, XIAP, CCND1
11agar459.3PTTG1, XIAP, CCND1
12ribonucleic acid459.3POMC, PTTG1, TSHR
13progesterone45 60 29 11 2413.1CCND1, POMC, TSHR, TP63
14retinoic acid45 249.9TP63, TSHR, XIAP, CCND1, RPE65
15paraffin458.9CCND1, XIAP, POMC, TSHR, TP63
16thymidine45 249.9TP63, TSHR, PTTG1, CCND1
17phosphatidylinositol458.9TSHR, PTTG1, XIAP, CCND1
18vegf458.0TP63, TSHR, PTTG1, POMC, XIAP, CCND1
19calcium45 50 11 2410.6CCL21, XIAP, CXCL13, PTTG1, TSHR, TP63

GO Terms for genes affiliated with Thymic Hyperplasia

Sources:
16Gene Ontology
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Biological processes related to Thymic Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:0101659.6TP63, CCND1
2mitotic G1 DNA damage checkpointGO:0315719.3TP63, CCND1
3cell-cell signalingGO:0072678.3TSHR, CXCL13, POMC, CCL21

Molecular functions related to Thymic Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.1CXCL13, CCL21

Products for genes affiliated with Thymic Hyperplasia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thymic Hyperplasia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet