MCID: THY043
MIFTS: 36

Thymic Hyperplasia malady

Rare diseases, Endocrine diseases categories

Summaries for Thymic Hyperplasia

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MalaCards based summary: Thymic Hyperplasia, also known as hyperplasia of thymus gland, is related to thyroiditis and thyroid cancer. An important gene associated with Thymic Hyperplasia is RPE65 (retinal pigment epithelium-specific protein 65kDa), and among its related pathways are Small cell lung cancer and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The compounds indole-3-carbinol and dutp have been mentioned in the context of this disorder. Affiliated tissues include thymus, t cells and thyroid, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Aliases & Classifications for Thymic Hyperplasia

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Thymic Hyperplasia, Aliases & Descriptions:

Name: Thymic Hyperplasia 41
Hyperplasia of Thymus Gland 41
 
Thymus Hyperplasia 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


Related Diseases for Thymic Hyperplasia

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Graphical network of the top 20 diseases related to Thymic Hyperplasia:



Diseases related to thymic hyperplasia

Symptoms for Thymic Hyperplasia

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Drugs & Therapeutics for Thymic Hyperplasia

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Drug clinical trials:

Search ClinicalTrials for Thymic Hyperplasia

Search NIH Clinical Center for Thymic Hyperplasia

Genetic Tests for Thymic Hyperplasia

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Anatomical Context for Thymic Hyperplasia

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MalaCards organs/tissues related to Thymic Hyperplasia:

31
Thymus, T cells, Thyroid, Lung, Breast, Myeloid, Hypothalamus, Pituitary

Animal Models for Thymic Hyperplasia or affiliated genes

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MGI Mouse Phenotypes related to Thymic Hyperplasia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.0PTTG1, TP63, TSHR, CCND1, XIAP
2MP:00053797.9PTTG1, TP63, POMC, TSHR, CCND1, XIAP
3MP:00053977.7PTTG1, POMC, TSHR, CXCL13, CCND1, XIAP
4MP:00107687.7XIAP, CCND1, TSHR, POMC, TP63, PTTG1
5MP:00053867.6XIAP, PTTG1, TP63, POMC, TSHR, CCND1
6MP:00053847.6PTTG1, TP63, POMC, CXCL13, CCND1, XIAP
7MP:00053767.6PTTG1, TP63, POMC, TSHR, CCND1, RPE65
8MP:00053787.4PTTG1, TP63, POMC, TSHR, CCND1, XIAP
9MP:00053877.4PTTG1, TP63, POMC, TSHR, CXCL13, CCND1

Publications for Thymic Hyperplasia

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Articles related to Thymic Hyperplasia:

(show top 50)    (show all 174)
idTitleAuthorsYear
1
Chemical-shift MRI of rebound thymic hyperplasia with unusual appearance and intense (18)F-FDG uptake in adulthood: report of two cases. (24667047)
2014
2
Reactive thymic hyperplasia following chemotherapy for children with lymphoma: computed tomography may be able to provide valuable information to avoid over-treatment. (25079775)
2014
3
Severe thymic hyperplasia in a newborn calf associated with impaired T-cell differentiation. (23864259)
2013
4
FDG PET/CT findings of thyrotoxicosis induced thymic hyperplasia associated to interferon. (23036823)
2013
5
Thymic Hyperplasia Associated with Graves' Disease in a 10-year-old Boy. (23926397)
2011
6
Thymic hyperplasia after lung transplantation imitating posttransplant lymphoproliferative disorder. (23213605)
2011
7
Visual vignette. What is the diagnosis? Thymic hyperplasia associated with Graves disease. (21803716)
2011
8
Thymic hyperplasia and Graves disease: management of anterior mediastinal masses in patients with Graves disease. (19491074)
2009
9
Benign thymic hyperplasia: an unexpected cause of respiratory distress during inhalatory induction of anesthesia. (19624373)
2009
10
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia. (19847900)
2009
11
Rebound thymic hyperplasia after pneumonectomy and chemotherapy for primary synovial sarcoma. (18728544)
2008
12
Thyrotoxic myopathy mimicking myasthenic syndrome associated with thymic hyperplasia. (18310980)
2008
13
Benign thymic hyperplasia: an unexpected cause of respiratory distress during inhalatory induction of anesthesia. (19076582)
2008
14
Thymic hyperplasia in a child treated with growth hormone. (17141546)
2007
15
False-positive iodine uptake in thymic hyperplasia on diagnostic I-123 whole-body scan after total thyroidectomy. (17242577)
2007
16
Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1. (17160015)
2007
17
An unusual cause of anterior mediastinal mass: thymic hyperplasia resulting from Graves disease. (16755190)
2006
18
A mediastinal mass: Graves' disease related thymic hyperplasia. (16314247)
2005
19
Thymic hyperplasia following successful treatment for nodular-sclerosing Hodgkin's disease. (14565667)
2003
20
Thymic hyperplasia and lung carcinomas in a line of mice transgenic for keratin 5-driven HPV16 E6/E7 oncogenes. (11781829)
2001
21
Thymic hyperplasia: a cause of respiratory distress. (11715897)
2001
22
Iodine-131 uptake in thymic hyperplasia with atypical computed tomographic features. (10795701)
2000
23
Normalization of elevated CD4-/CD8- (double-negative) T cells after thymectomy parallels clinical remission in myasthenia gravis associated with thymic hyperplasia but not thymoma. (11026443)
2000
24
Cytologic diagnosis of true thymic hyperplasia by combined radiologic imaging and aspiration cytology: a case report including flow cytometric analysis. (11074650)
2000
25
Pseudo-myasthenia gravis and thymic hyperplasia in Graves' disease. (10451743)
1999
26
Chromosomal proviral sequences of human immunodeficiency virus in multiple thymic cell types in a patient with acquired immunodeficiency syndrome and massive thymic hyperplasia. (9849994)
1998
27
True massive thymic hyperplasia. (9022591)
1997
28
Induction of thymic hyperplasia and suppression of splenic T cells by lesioning of the anterior hypothalamus in aging Wistar rats. (9258247)
1997
29
Case report: true massive thymic hyperplasia. (8549051)
1996
30
Macrophage subpopulations in the thymic hyperplasia of patients with myasthenia gravis. (8688498)
1995
31
Massive thymic hyperplasia: characterization of a rare mediastinal mass. (7877028)
1994
32
Gallium-67 imaging for thymic hyperplasia in adults following chemotherapy. (8204178)
1993
33
Thymic hyperplasia in adults following chemotherapy for malignancy. (7688954)
1993
34
Massive thymic hyperplasia. (8494431)
1993
35
Thymic hyperplasia with hemorrhage simulating recurrent Hodgkin disease after chemotherapy-induced complete remission. (1382826)
1992
36
Thymic hyperplasia after chemotherapy: two case reports and a literature review. (1940299)
1991
37
Acromegaly and thymic hyperplasia: a case report. (2090673)
1990
38
A case of massive true thymic hyperplasia with non-Hodgkin's lymphoma. (2225994)
1990
39
Film panel cases Society of Pediatric Radiology. Thymic hyperplasia. (2349023)
1990
40
Thymic hyperplasia. A clue to the diagnosis of hyperthyroidism. (2220714)
1990
41
Thymic hyperplasia following chemotherapy of a testicular germ cell tumor. Immunohistological evidence for a simple rebound phenomenon. (2536289)
1989
42
Epithelial proliferation in thymic hyperplasia. An immunohistochemical study and correlation with the developing fetal thymus. (2705869)
1989
43
Thymic hyperplasia. II. Lymphofollicular hyperplasia of the thymus. An immunohistologic study. (2435953)
1987
44
Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen. (3118193)
1987
45
Mediastinal mass following chemotherapeutic treatment of Hodgkin's disease: recurrent tumor or thymic hyperplasia? (3440903)
1987
46
Thymic hyperplasia. I. True thymic hyperplasia. Review of the literature. (3560787)
1987
47
Thymic hyperplasia following successful chemotherapy. A report of two cases and review of the literature. (4027888)
1985
48
Thymic hyperplasia and neoplasia: a review of current concepts. (361541)
1978
49
The level of immunoglobulins in healthy children with thymic hyperplasia. (5370555)
1969
50
The level of immunoglobulins in sick children with thymic hyperplasia. (5370556)
1969

Variations for Thymic Hyperplasia

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Expression for genes affiliated with Thymic Hyperplasia

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Search GEO for disease gene expression data for Thymic Hyperplasia.

Pathways for genes affiliated with Thymic Hyperplasia

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Pathways related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CCND1, XIAP
2
Show member pathways
9.3CCL21, CXCL13
3
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling58
9.3CCL21, CXCL13
48.9PTTG1, CCND1, XIAP
5
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.9XIAP, CCND1, PTTG1
6
Show member pathways
8.6CCL21, CXCL13, TSHR, POMC
7
Show member pathways
7.9RPE65, POMC, TSHR, CXCL13, CCND1, CCL21

Compounds for genes affiliated with Thymic Hyperplasia

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Compounds related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

(show all 28)
idCompoundScoreTop Affiliating Genes
1indole-3-carbinol4310.0XIAP, CCND1
2dutp4310.0CCND1, XIAP
3sulindac43 1211.0CCND1, XIAP
4methimazole43 2 1212.0POMC, TSHR
5noxa4310.0XIAP, TP63
6suberoylanilide hydroxamic acid439.9XIAP, CCND1
7roscovitine439.9XIAP, CCND1
8flavopiridol43 1210.9CCND1, XIAP
9hematoxylin439.8RPE65, TP63
10rottlerin439.8CCND1, XIAP
11triiodothyronine439.8TSHR, POMC
12vincristine43 49 1211.8XIAP, CCND1, POMC
13teck439.7CCL21, CXCL13
14bortezomib43 49 1211.6CCND1, XIAP
15doxorubicin43 49 1211.5TP63, CCND1, XIAP
16estradiol43 24 1211.4XIAP, CCND1, TSHR, POMC
17cisplatin43 49 59 1212.3XIAP, CCND1, TP63
18agar439.2XIAP, CCND1, PTTG1
19ribonucleic acid439.2PTTG1, POMC, TSHR
20progesterone43 28 59 24 1213.2TP63, POMC, TSHR, CCND1
21retinoic acid43 2410.0TP63, TSHR, CCND1, RPE65, XIAP
22paraffin438.9TP63, POMC, TSHR, CCND1, XIAP
23ag 1478438.9CCND1, PTTG1
24phosphatidylinositol438.9PTTG1, TSHR, CCND1, XIAP
25thymidine43 249.8PTTG1, TP63, TSHR, CCND1
26estrogen438.4PTTG1, TP63, POMC, TSHR, CCND1
27vegf437.8XIAP, RPE65, CCND1, TSHR, POMC, TP63
28calcium43 49 24 1210.7PTTG1, TP63, TSHR, CXCL13, CCL21, XIAP

GO Terms for genes affiliated with Thymic Hyperplasia

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Biological processes related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:00101659.6CCND1, TP63
2mitotic G1 DNA damage checkpointGO:00315719.3CCND1, TP63
3cell-cell signalingGO:00072678.5CCL21, CXCL13, TSHR, POMC

Molecular functions related to Thymic Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.3CCL21, CXCL13

Products for genes affiliated with Thymic Hyperplasia

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Sources for Thymic Hyperplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet