MCID: THY023
MIFTS: 66

Thymoma malady

Cancer diseases, Rare diseases categories
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Summaries for Thymoma

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Sources:
65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Thymoma is a tumor originating from the epithelial cells of the thymus. Thymoma is an uncommon tumor,... more...

MalaCards: Thymoma, also known as primary thymic epithelial neoplasm, is related to myasthenia gravis and thyroiditis, and has symptoms including myasthenia, peritoneal diseases and bone marrow failure/pancytopenia. An important gene associated with Thymoma is AKT2 (v-akt murine thymoma viral oncogene homolog 2), and among its related pathways are NGF Pathway and Apoptosis and survival Caspase cascade. The compounds sc 79 and fpa 124 have been mentioned in the context of this disorder. Affiliated tissues include thymus, t cells and lung, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Description from OMIM:47 274230

Aliases & Classifications for Thymoma

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 49 
Rare tumors


Characteristics (Orphanet epidemiological data):

49
thymoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

thymoma 8 10 45 49 47 62
primary thymic epithelial neoplasm 49
primary thymic epithelial tumor 49
thymoma nos 8


External Ids:

Disease Ontology8 DOID:3275
NCIt40 C3411
MeSH35 D013945
SNOMED-CT via Orphanet59 128856005, 444231005
UMLS via Orphanet63 C0040100
OMIM47 274230
MESH via Orphanet36 D013945
ICD10 via Orphanet26 C37, D15.0

Related Diseases for Thymoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Thymoma family:

Malignant Type a Thymoma Malignant Type Ab Thymoma
Type C Thymoma Thymoma Type a
Thymoma Type B Thymoma Type Ab

Diseases related to Thymoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1myasthenia gravis31.2TNFRSF4, AIRE, CTLA4, RYR1
2thyroiditis30.6CTLA4
3leukemia30.4AKT1, TNFRSF4, EVPL, CD2, CD5
4systemic lupus erythematosus30.2CD2, TNFRSF4, CTLA4
5autoimmune hepatitis30.1AIRE, CTLA4
6lung cancer30.1CTLA4, SSTR2, AKT1, AKT2, NKX2-1
7hypothyroidism30.0AIRE, NKX2-1
8thymus cancer30.0NKX2-1, CD5
9hypoparathyroidism29.8AIRE, CTLA4
10vitiligo29.8AIRE, CTLA4
11diabetes mellitus29.7CTLA4, AIRE, AKT2, AKT1
12melanoma29.7AKT1, NKX2-1, CD2, CTLA4, SSTR2, AKT3
13graves' disease29.7NKX2-1, TNFRSF4, AIRE, CTLA4
14breast cancer29.6SSTR2, CTLA4, AKT2, AKT3, AKT1
15thymic carcinoma10.7
16pure red-cell aplasia10.6
17pemphigus10.5
18cervicitis10.5
19encephalitis10.4
20mediastinitis10.4
21good syndrome10.4
22spindle cell thymoma10.4
23myocarditis10.4
24candidiasis10.3
25limbic encephalitis10.3
26cortical thymoma10.3
27lichen planus10.3
28chronic mucocutaneous candidiasis10.3
29invasive malignant thymoma10.3
30stiff-person syndrome10.3
31giant cell myocarditis10.3
32thymic epithelial neoplasm10.3
33intestinal pseudo-obstruction10.2
34lupus erythematosus10.2
35myositis10.2
36paraneoplastic pemphigus10.2
37epithelial malignant thymoma10.2
38encapsulated thymoma10.2
39polymyositis10.2
40superior vena cava syndrome10.2
41thymic hyperplasia10.2
42paraneoplastic syndromes10.2
43dermatitis10.2
44lymphoblastic leukemia10.2
45type c thymoma10.2
46pemphigus erythematosus10.2
47noninvasive malignant thymoma10.1
48malignant type a thymoma10.1
49malignant type ab thymoma10.1
50pancytopenia10.1

Graphical network of the top 20 diseases related to Thymoma:



Diseases related to thymoma

Symptoms for Thymoma

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Sources:
47OMIM, 49Orphanet
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Symptoms by clinical synopsis from OMIM:

274230

Clinical features from OMIM:

274230

Symptoms:

49 (show all 35)
  • myasthenia
  • peritoneal diseases
  • bone marrow failure/pancytopenia
  • xerophthalmia/dry eyes
  • mediastinal anomalies
  • lymphocytes anomalies
  • asthenia/fatigue/weakness
  • thymus/thymic neoplasm/tumor/carcinoma/cancer/thymoma
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • cushingoid morphotype
  • myositis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • cough
  • thoracic/chest pain
  • mouth dryness/xerostomia
  • cutaneous rash
  • restricted joint mobility/joint stiffness/ankylosis
  • arthritis/synovitis/synovial proliferation
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • ptosis
  • myocardium anomalies/myocarditis
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • lymphadenopathy/polyadenopathies
  • bone/osseous neoplasm/tumor/carcinoma/cancer
  • alopecia
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • thymic aplasia/hypoplasia
  • thyroiditis
  • nephrotic syndrome
  • agammaglobulinemia/hypogammaglobulinemia/b-cell deficiency
  • hemolytic anemia
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • diplopia/double vision

Drugs & Therapeutics for Thymoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Thymoma

Search NIH Clinical Center for Thymoma

Genetic Tests for Thymoma

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Anatomical Context for Thymoma

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Sources:
33MalaCards
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MalaCards organs/tissues related to Thymoma:

33
Thymus, T cells, Lung, Thyroid, Bone, B cells, Bone marrow, Liver, Eye, Brain, Breast, Skin, Lymph node, Pituitary, Testes, Heart, Colon, Placenta, Endothelial

Animal Models for Thymoma or affiliated genes

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Sources:
37MGI
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Publications for Thymoma

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Sources:
52PubMed
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Articles related to Thymoma:

(show top 50)    (show all 859)
idTitleAuthorsYear
1
Extended Surgical Resections of Advanced Thymoma Masaoka Stages III and IVa Facilitate Outcome. (23775415)
2013
2
Imaging of a case of metaplastic thymoma on 18F-FDG PET/CT. (24212449)
2013
3
Characterization of malignant thrombus in an invasive thymoma with intravascular growth. (23705036)
2013
4
Port-site recurrence after complete resection of stage I thymoma by video-assisted thoracoscopic surgery: report of a case. (24241478)
2013
5
Thymoma: current diagnosis and treatment. (23769581)
2013
6
Teaching Video NeuroImages: myokymia and nerve hyperexcitability as components of Morvan syndrome due to malignant thymoma. (23359380)
2013
7
Thymoma originating in a giant thymolipoma: a rare intrathoracic lesion. (23992709)
2013
8
V-AKT murine thymoma viral oncogene homolog/mammalian target of rapamycin activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis. (22271091)
2012
9
Evaluation of the role of radiation therapy in the management of malignant thymoma. (21596484)
2012
10
Pulmonary metastasis from encapsulated cervical ectopic type a thymoma. (23176955)
2012
11
Unusual cause of cardiac compression in a trauma patient: cystic thymoma. (23358097)
2012
12
Expression of P120 catenin, Kaiso, and metastasis tumor antigen-2 in thymomas. (22833212)
2012
13
Myelodysplasia followed by Good's Syndrome: a unique manifestation associated with thymoma. (22453074)
2012
14
Management and outcomes of relapse after treatment for thymoma and thymic carcinoma. (22115206)
2011
15
Thymoma: inter-relationships among World Health Organization histology, Masaoka staging and myasthenia gravis and their independent prognostic significance: a single-centre experience. (21093283)
2011
16
Computed tomography findings predicting invasiveness of thymoma. (21623235)
2011
17
Oral erosive lichen planus and alopecia areata with Good's syndrome (thymoma with hypogammaglobulinemia). (21282092)
2011
18
Thymoma associated with malignancies may herald a hereditary cancer syndrome. (20734236)
2010
19
The occurrence of stiff person syndrome in a patient with thymoma: case report and literature review. (20509396)
2010
20
Spontaneous regression of an invasive thymoma. (20401719)
2010
21
Thymoma: Results of treatment and role of radiotherapy. (24376917)
2010
22
Bilateral exophthalmos in a rabbit. Diagnosis: Thymoma. (20729825)
2010
23
Cancer-associated retinopathy caused by benign thymoma. (20424218)
2010
24
Postoperative radiotherapy after surgical resection of thymoma: differing roles in localized and regional disease. (19427738)
2010
25
Imatinib mesylate in patients with WHO B3 thymomas and thymic carcinomas. (20197733)
2009
26
Giant cystic thymoma with haemorrhage and necrosis: an unusual case. (19445448)
2009
27
An unusual case of malignant thymoma associated graft-versus-host disease. (21853007)
2009
28
Association between thymoma and persistent hypothermia: a case report. (19946549)
2009
29
The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis. (19693092)
2009
30
Autoimmune haemolytic anaemia associated with a thymoma: case report and review of the literature. (19999396)
2009
31
Cystic thymoma coexisting with vascular dysplasia. (19024220)
2008
32
Thymomas: a cytological and immunohistochemical study, with emphasis on lymphoid and neuroendocrine markers. (17498299)
2007
33
Expression of autoimmune regulator gene (AIRE) and T regulatory cells in human thymomas. (17590173)
2007
34
Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1). (17334980)
2007
35
Pure red cell aplasia with malignant thymoma: a rarity. (17183851)
2006
36
Malignant thymoma associated with fatal myocarditis and polymyositis in a 32-year-old woman with a history of hairy cell leukemia. (16601447)
2006
37
Malignant melanoma of mediastinum misdiagnosed as a spindle cell thymoma in a fine needle aspirate: a case report. (16124173)
2005
38
Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia. (12515721)
2003
39
Serum level of the periostin, a homologue of an insect cell adhesion molecule, in thymoma patients. (11595127)
2001
40
Autocrine motility factor receptor expression associates with tumor progression in thymoma. (10891533)
2000
41
Thymoma and thymic carcinoma. (10366159)
1999
42
Thymoma-associated pancytopenia: effectiveness of cyclosporine A. (9829850)
1998
43
Resolution of exfoliative dermatitis and Malassezia pachydermatis overgrowth in a cat after surgical thymoma resection. (9358405)
1997
44
A new mouse gene, SRG3, related to the SWI3 of Saccharomyces cerevisiae, is required for apoptosis induced by glucocorticoids in a thymoma cell line. (9151708)
1997
45
Successful treatment of a patient with a thymoma and pure red-cell aplasia with octreotide and prednisone. (8995089)
1997
46
Oncogene proteins and proliferation antigens in thymomas: increased expression of epidermal growth factor receptor and Ki67 antigen. (7629292)
1995
47
Tissue distribution of very late activation antigens-1/6 and very late activation antigen ligands in the normal thymus and in thymoma. (8456937)
1993
48
Acute intestinal pseudo-obstruction due to malignant thymoma. (8266165)
1993
49
Thymic carcinosarcoma associated with a spindle cell thymoma: an immunohistochemical study. (1398523)
1992
50
Androgen therapy for refractory anemia: report of a case associated with thymoma. (13760488)
1960

Variations for Thymoma

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Expression for genes affiliated with Thymoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thymoma

Search GEO for disease gene expression data for Thymoma.

Pathways for genes affiliated with Thymoma

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Sources:
50PathCards, 53QIAGEN, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 54R&D Systems, 51PharmGKB, 57SinoBiological, 61Tocris Bioscience, 5Cell Signaling Technology
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Pathways related to Thymoma according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7AKT1, AKT3, AKT2
2
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.7AKT2, AKT3, AKT1
39.7AKT1, AKT3, AKT2
4
Show member pathways
Development A2B receptor action via G protein alpha s60
9.7AKT2, AKT3, AKT1
5
Show member pathways
Development Flt3 signaling60
9.7AKT2, AKT3, AKT1
69.7AKT1, AKT3, AKT2
7
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.7AKT2, AKT3, AKT1
8
Show member pathways
9.7AKT2, AKT3, AKT1
9
Show member pathways
IFN-gamma pathway38
9.7AKT1, AKT3, AKT2
10
Show member pathways
Immune response IL 3 activation and signaling pathway60
9.7AKT1, AKT3, AKT2
11
Show member pathways
9.7AKT1, AKT3, AKT2
12
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.7AKT1, AKT3, AKT2
13
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.7AKT2, AKT3, AKT1
149.7AKT2, AKT3, AKT1
15
Show member pathways
9.7AKT1, AKT3, AKT2
16
Show member pathways
Development A1 receptor signaling60
G protein signaling G Protein alpha q signaling cascades60
9.7AKT1, AKT3, AKT2
179.7AKT2, AKT3, AKT1
18
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis60
9.7AKT2, AKT3, AKT1
199.7AKT2, AKT3, AKT1
209.7AKT1, AKT3, AKT2
219.7AKT2, AKT3, AKT1
22
Show member pathways
9.7AKT2, AKT3, AKT1
239.7AKT2, AKT3, AKT1
249.7AKT1, AKT3, AKT2
25
Show member pathways
DNA damage Role of SUMO in p53 regulation60
9.7AKT1, AKT3, AKT2
26
Show member pathways
9.7AKT1, AKT3, AKT2
279.7AKT2, AKT3, AKT1
28
Show member pathways
9.7AKT2, AKT3, AKT1
299.7AKT1, AKT3, AKT2
309.7AKT2, AKT3, AKT1
319.7AKT2, AKT3, AKT1
32
Show member pathways
9.7AKT2, AKT3, AKT1
33
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling60
9.7AKT1, AKT3, AKT2
349.7AKT1, AKT3, AKT2
35
Show member pathways
9.7AKT1, AKT3, AKT2
369.7AKT2, AKT3, AKT1
379.7AKT2, AKT3, AKT1
389.7AKT1, AKT3, AKT2
39
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.7AKT2, AKT3, AKT1
40
Show member pathways
9.4AKT1, AKT3, AKT2, TNFRSF4
41
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.2AKT2, AKT3, AKT1, NKX2-1
42
Show member pathways
9.1AKT2, AKT3, AKT1, RYR1
43
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
9.1RYR1, AKT1, AKT3, AKT2
44
Show member pathways
9.0TNFRSF4, AKT2, AKT3, AKT1, CD2
45
Show member pathways
9.0TNFRSF4, AKT2, AKT3, AKT1, CD2
46
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.9AKT2, AKT3, AKT1, CTLA4
47
Show member pathways
8.9AKT2, AKT3, AKT1, CTLA4
48
Show member pathways
8.9CTLA4, AKT1, AKT3, AKT2
49
Show member pathways
8.9CTLA4, AKT1, AKT3, AKT2
50
Show member pathways
8.6AIRE, AKT2, AKT3, AKT1, CTLA4

Compounds for genes affiliated with Thymoma

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Sources:
61Tocris Bioscience, 45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR
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Compounds related to Thymoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1sc 796110.1AKT1, AKT3, AKT2
2fpa 1246110.1AKT2, AKT3, AKT1
310-debc hydrochloride6110.1AKT2, AKT3, AKT1
4api-16110.0AKT2, AKT3, AKT1
5api-26110.0AKT1, AKT3, AKT2
6sodium iodide459.7NKX2-1, SSTR2
7sb 20358045 6110.7AIRE, AKT2, AKT1
8ouabain45 1110.6RYR1, AKT1
9con a459.3CTLA4, CD2
10gnrh459.3AKT1, SSTR2, NKX2-1
11tamoxifen45 51 29 1112.2AKT2, AKT1, SSTR2
12ly294002459.2CTLA4, AKT1, AKT3, AKT2
13ionomycin459.1CTLA4, CD2, TNFRSF4
14paraffin459.0AKT1, SSTR2, NKX2-1, CD5
15wortmannin459.0AKT2, AKT1, CD2, CTLA4
16rapamycin458.8AKT2, AKT1, CTLA4, RYR1
17phosphatidylinositol458.8CTLA4, AKT1, AKT3, AKT2
18threonine458.6AKT2, AKT3, AKT1, NKX2-1, CTLA4
19estrogen458.3AKT2, AKT1, SSTR2, NKX2-1, CTLA4
20lipid458.2AKT2, AKT3, AKT1, CD2, CTLA4, RYR1
21glucose458.0AKT2, AKT1, SSTR2, CD2, CTLA4, RYR1
22serine457.8AIRE, AKT2, AKT3, AKT1, NKX2-1, CTLA4
23tyrosine457.4AIRE, AKT2, AKT1, SSTR2, NKX2-1, CD2

GO Terms for genes affiliated with Thymoma

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Sources:
16Gene Ontology
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Cellular components related to Thymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5CTLA4, CD5, CD2, TNFRSF4
2integral component of plasma membraneGO:0058877.1RYR1, TNFRSF4, SSTR2, CD2, CD5, CTLA4
3plasma membraneGO:0058866.4AKT2, AKT3, AKT1, SSTR2, CD2, CD5

Biological processes related to Thymoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of plasma membrane long-chain fatty acid transportGO:01074810.1AKT1, AKT2
2positive regulation of glucose metabolic processGO:01090710.1AKT1, AKT2
3peripheral nervous system myelin maintenanceGO:03228710.0AKT2, AKT1
4mammary gland epithelial cell differentiationGO:06064410.0AKT1, AKT2
5positive regulation of glucose importGO:04632610.0AKT1, AKT2
6positive regulation of glycogen biosynthetic processGO:0457259.9AKT1, AKT2
7glycogen biosynthetic processGO:0059789.7AKT1, AKT2
8T cell costimulationGO:0312959.1CTLA4, CD5, AKT1

Molecular functions related to Thymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:01630110.0AKT1, AKT2
2protein bindingGO:0055155.9RYR1, AIRE, AKT2, AKT3, AKT1, SSTR2

Products for genes affiliated with Thymoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thymoma

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet