MCID: THY023
MIFTS: 68

Thymoma malady

Cancer diseases, Rare diseases categories
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Summaries for Thymoma

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Disease Ontology:8 A thymus cancer that derives from epithelial cells located in the thymus. the tumor cells in a thymoma look similar to the normal cells of the thymus, grow slowly, and rarely spread beyond the thymus.

MalaCards based summary: Thymoma, also known as primary thymic epithelial neoplasm, is related to thyroiditis and myasthenia gravis, and has symptoms including mediastinal anomalies, lymphocytes anomalies and thymus/thymic neoplasm/tumor/carcinoma/cancer/thymoma. An important gene associated with Thymoma is AKT2 (v-akt murine thymoma viral oncogene homolog 2), and among its related pathways are NGF Pathway and Apoptosis and survival Caspase cascade. The compounds sc 79 and fpa 124 have been mentioned in the context of this disorder. Affiliated tissues include the thymus, thymus and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Wikipedia:65 Thymoma is a tumor originating from the epithelial cells of the thymus. Thymoma is an uncommon tumor,... more...

Description from OMIM:46 274230

Aliases & Classifications for Thymoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Thymoma, Aliases & Descriptions:

Name: Thymoma 8 10 44 48 46 62
Primary Thymic Epithelial Neoplasm 48
 
Primary Thymic Epithelial Tumor 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 48 
Rare tumors


Characteristics (Orphanet epidemiological data):

48
thymoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Normal


External Ids:

Disease Ontology8 DOID:3275
NCIt39 C3411
MeSH34 D013945
OMIM46 274230
MESH via Orphanet35 D013945
ICD10 via Orphanet26 C37, D15.0
UMLS via Orphanet63 C0040100

Related Diseases for Thymoma

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Diseases in the Thymoma family:

Malignant Type a Thymoma Malignant Type Ab Thymoma
Type C Thymoma Thymoma Type a
Thymoma Type B Thymoma Type Ab

Diseases related to Thymoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 235)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.1CTLA4
2myasthenia gravis31.0TNFRSF4, AIRE, CTLA4, RYR1
3thymus cancer30.3NKX2-1, CD5
4autoimmune hepatitis30.3AIRE, CTLA4
5hypothyroidism30.2AIRE, NKX2-1
6leukemia30.2AKT1, TNFRSF4, EVPL, CD2, CD5
7systemic lupus erythematosus30.1CD2, TNFRSF4, CTLA4
8hypoparathyroidism30.1AIRE, CTLA4
9vitiligo29.9AIRE, CTLA4
10diabetes mellitus29.8CTLA4, AIRE, AKT2, AKT1
11lung cancer29.8CTLA4, SSTR2, AKT1, AKT2, NKX2-1
12rheumatoid arthritis29.6AKT1, CTLA4, CD5, TNFRSF4
13graves' disease29.5NKX2-1, TNFRSF4, AIRE, CTLA4
14breast cancer29.3SSTR2, CTLA4, AKT2, AKT3, AKT1
15melanoma29.0AKT1, NKX2-1, CD2, CTLA4, SSTR2, AKT3
16thymic carcinoma10.7
17pure red-cell aplasia10.6
18pemphigus10.5
19cervicitis10.5
20mediastinitis10.5
21encephalitis10.5
22spindle cell thymoma10.5
23nonepidermolytic palmoplantar keratoderma10.4EVPL
24good syndrome10.4
25myocarditis10.4
26neuroendocrine tumor10.4SSTR2
27candidiasis10.4
28limbic encephalitis10.4
29cortical thymoma10.3
30wegener's granulomatosis10.3CTLA4
31lichen planus10.3
32stiff-person syndrome10.3
33invasive malignant thymoma10.3
34chronic mucocutaneous candidiasis10.3
35myositis10.3
36giant cell myocarditis10.3
37paraneoplastic pemphigus10.3
38epithelial malignant thymoma10.3
39intestinal pseudo-obstruction10.3
40lupus erythematosus10.3
41polymyositis10.3
42nodular goiter10.2CTLA4, TNFRSF4
43predominantly cortical thymoma10.2
44encapsulated thymoma10.2
45dermatitis10.2
46superior vena cava syndrome10.2
47thymic hyperplasia10.2
48paraneoplastic syndromes10.2
49type c thymoma10.2
50pancytopenia10.2

Graphical network of the top 20 diseases related to Thymoma:



Diseases related to thymoma

Symptoms for Thymoma

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Symptoms by clinical synopsis from OMIM:

274230

Clinical features from OMIM:

274230

Symptoms:

48 (show all 35)
  • mediastinal anomalies
  • lymphocytes anomalies
  • thymus/thymic neoplasm/tumor/carcinoma/cancer/thymoma
  • diplopia/double vision
  • ptosis
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • thoracic/chest pain
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • lymphadenopathy/polyadenopathies
  • myasthenia
  • asthenia/fatigue/weakness
  • xerophthalmia/dry eyes
  • mouth dryness/xerostomia
  • cutaneous rash
  • alopecia
  • peritoneal diseases
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • myocardium anomalies/myocarditis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • thymic aplasia/hypoplasia
  • nephrotic syndrome
  • thyroiditis
  • myositis
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • agammaglobulinemia/hypogammaglobulinemia/b-cell deficiency
  • bone marrow failure/pancytopenia
  • hemolytic anemia
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • bone/osseous neoplasm/tumor/carcinoma/cancer
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • cushingoid morphotype

HPO human phenotypes related to Thymoma:

(show all 33)
id Description Frequency HPO Source Accession
1 neoplasm of the thymus hallmark (90%) HP:0100521
2 mediastinal lymphadenopathy hallmark (90%) HP:0100721
3 ptosis typical (50%) HP:0000508
4 diplopia typical (50%) HP:0000651
5 respiratory insufficiency typical (50%) HP:0002093
6 fatigable weakness typical (50%) HP:0003473
7 feeding difficulties in infancy typical (50%) HP:0008872
8 chest pain typical (50%) HP:0100749
9 nephrotic syndrome occasional (7.5%) HP:0000100
10 xerostomia occasional (7.5%) HP:0000217
11 skin rash occasional (7.5%) HP:0000988
12 keratoconjunctivitis sicca occasional (7.5%) HP:0001097
13 arthritis occasional (7.5%) HP:0001369
14 limitation of joint mobility occasional (7.5%) HP:0001376
15 hypercortisolism occasional (7.5%) HP:0001578
16 alopecia occasional (7.5%) HP:0001596
17 abnormality of the myocardium occasional (7.5%) HP:0001637
18 abnormality of the pericardium occasional (7.5%) HP:0001697
19 hemolytic anemia occasional (7.5%) HP:0001878
20 abnormality of the pleura occasional (7.5%) HP:0002103
21 abnormality of the peritoneum occasional (7.5%) HP:0002585
22 neoplasm of the liver occasional (7.5%) HP:0002896
23 hypogammaglobulinemia occasional (7.5%) HP:0004313
24 neoplasm of the nervous system occasional (7.5%) HP:0004375
25 bone marrow hypocellularity occasional (7.5%) HP:0005528
26 aplasia/hypoplasia of the thymus occasional (7.5%) HP:0010515
27 neoplasm of the skeletal system occasional (7.5%) HP:0010622
28 neoplasm of the lung occasional (7.5%) HP:0100526
29 myositis occasional (7.5%) HP:0100614
30 thyroiditis occasional (7.5%) HP:0100646
31 autosomal recessive inheritance HP:0000007
32 respiratory insufficiency HP:0002093
33 thymoma HP:0100522

Drugs & Therapeutics for Thymoma

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Drug clinical trials:

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Genetic Tests for Thymoma

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Anatomical Context for Thymoma

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MalaCards organs/tissues related to Thymoma:

32
Thymus, T cells, Lung, Thyroid, Bone, B cells, Bone marrow, Liver, Eye, Brain, Breast, Skin, Lymph node, Heart, Colon, Placenta, Testes, Endothelial, Pituitary, Neutrophil

FMA organs/tissues related to Thymoma:

14
The thymus

Animal Models for Thymoma or affiliated genes

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Publications for Thymoma

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Articles related to Thymoma:

(show top 50)    (show all 888)
idTitleAuthorsYear
1
Histologic classification of thymoma: a practical guide for routine cases. (25396309)
2014
2
Thymoma complicated by acquired amegakaryocytic thrombocytopenia and pure red cell aplasia. (25361796)
2014
3
Extended Surgical Resections of Advanced Thymoma Masaoka Stages III and IVa Facilitate Outcome. (23775415)
2013
4
Imaging of a case of metaplastic thymoma on 18F-FDG PET/CT. (24212449)
2013
5
Characterization of malignant thrombus in an invasive thymoma with intravascular growth. (23705036)
2013
6
Port-site recurrence after complete resection of stage I thymoma by video-assisted thoracoscopic surgery: report of a case. (24241478)
2013
7
Thymoma: current diagnosis and treatment. (23769581)
2013
8
Teaching Video NeuroImages: myokymia and nerve hyperexcitability as components of Morvan syndrome due to malignant thymoma. (23359380)
2013
9
Thymoma originating in a giant thymolipoma: a rare intrathoracic lesion. (23992709)
2013
10
V-AKT murine thymoma viral oncogene homolog/mammalian target of rapamycin activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis. (22271091)
2012
11
Evaluation of the role of radiation therapy in the management of malignant thymoma. (21596484)
2012
12
Pulmonary metastasis from encapsulated cervical ectopic type a thymoma. (23176955)
2012
13
Unusual cause of cardiac compression in a trauma patient: cystic thymoma. (23358097)
2012
14
Expression of P120 catenin, Kaiso, and metastasis tumor antigen-2 in thymomas. (22833212)
2012
15
Myelodysplasia followed by Good's Syndrome: a unique manifestation associated with thymoma. (22453074)
2012
16
Management and outcomes of relapse after treatment for thymoma and thymic carcinoma. (22115206)
2011
17
Computed tomography findings predicting invasiveness of thymoma. (21623235)
2011
18
Oral erosive lichen planus and alopecia areata with Good's syndrome (thymoma with hypogammaglobulinemia). (21282092)
2011
19
Thymoma associated with malignancies may herald a hereditary cancer syndrome. (20734236)
2010
20
The occurrence of stiff person syndrome in a patient with thymoma: case report and literature review. (20509396)
2010
21
Spontaneous regression of an invasive thymoma. (20401719)
2010
22
Thymoma: Results of treatment and role of radiotherapy. (24376917)
2010
23
Bilateral exophthalmos in a rabbit. Diagnosis: Thymoma. (20729825)
2010
24
Cancer-associated retinopathy caused by benign thymoma. (20424218)
2010
25
Postoperative radiotherapy after surgical resection of thymoma: differing roles in localized and regional disease. (19427738)
2010
26
Imatinib mesylate in patients with WHO B3 thymomas and thymic carcinomas. (20197733)
2009
27
Giant cystic thymoma with haemorrhage and necrosis: an unusual case. (19445448)
2009
28
An unusual case of malignant thymoma associated graft-versus-host disease. (21853007)
2009
29
Association between thymoma and persistent hypothermia: a case report. (19946549)
2009
30
The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis. (19693092)
2009
31
Cystic thymoma coexisting with vascular dysplasia. (19024220)
2008
32
Thymomas: a cytological and immunohistochemical study, with emphasis on lymphoid and neuroendocrine markers. (17498299)
2007
33
Expression of autoimmune regulator gene (AIRE) and T regulatory cells in human thymomas. (17590173)
2007
34
Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1). (17334980)
2007
35
Pure red cell aplasia with malignant thymoma: a rarity. (17183851)
2006
36
Malignant thymoma associated with fatal myocarditis and polymyositis in a 32-year-old woman with a history of hairy cell leukemia. (16601447)
2006
37
Malignant melanoma of mediastinum misdiagnosed as a spindle cell thymoma in a fine needle aspirate: a case report. (16124173)
2005
38
Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia. (12515721)
2003
39
Serum level of the periostin, a homologue of an insect cell adhesion molecule, in thymoma patients. (11595127)
2001
40
Autocrine motility factor receptor expression associates with tumor progression in thymoma. (10891533)
2000
41
Thymoma and thymic carcinoma. (10366159)
1999
42
Thymoma-associated pancytopenia: effectiveness of cyclosporine A. (9829850)
1998
43
Resolution of exfoliative dermatitis and Malassezia pachydermatis overgrowth in a cat after surgical thymoma resection. (9358405)
1997
44
A new mouse gene, SRG3, related to the SWI3 of Saccharomyces cerevisiae, is required for apoptosis induced by glucocorticoids in a thymoma cell line. (9151708)
1997
45
Successful treatment of a patient with a thymoma and pure red-cell aplasia with octreotide and prednisone. (8995089)
1997
46
Oncogene proteins and proliferation antigens in thymomas: increased expression of epidermal growth factor receptor and Ki67 antigen. (7629292)
1995
47
Tissue distribution of very late activation antigens-1/6 and very late activation antigen ligands in the normal thymus and in thymoma. (8456937)
1993
48
Acute intestinal pseudo-obstruction due to malignant thymoma. (8266165)
1993
49
Thymic carcinosarcoma associated with a spindle cell thymoma: an immunohistochemical study. (1398523)
1992
50
Androgen therapy for refractory anemia: report of a case associated with thymoma. (13760488)
1960

Variations for Thymoma

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Expression for genes affiliated with Thymoma

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Expression patterns in normal tissues for genes affiliated with Thymoma

Search GEO for disease gene expression data for Thymoma.

Pathways for genes affiliated with Thymoma

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Pathways related to Thymoma according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7AKT2, AKT3, AKT1
2
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
9.7AKT2, AKT1, AKT3
39.7AKT2, AKT3, AKT1
4
Show member pathways
Development A2B receptor action via G protein alpha s60
9.7AKT2, AKT3, AKT1
5
Show member pathways
Development Flt3 signaling60
9.7AKT2, AKT1, AKT3
69.7AKT2, AKT3, AKT1
79.7AKT1, AKT3, AKT2
8
Show member pathways
9.7AKT3, AKT1, AKT2
9
Show member pathways
IFN-gamma pathway37
9.7AKT2, AKT1, AKT3
10
Show member pathways
Immune response IL 3 activation and signaling pathway60
9.7AKT3, AKT1, AKT2
11
Show member pathways
9.7AKT3, AKT2, AKT1
12
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.7AKT3, AKT1, AKT2
139.7AKT2, AKT3, AKT1
149.7AKT1, AKT3, AKT2
15
Show member pathways
9.7AKT2, AKT3, AKT1
16
Show member pathways
Development A1 receptor signaling60
G protein signaling G Protein alpha q signaling cascades60
9.7AKT2, AKT3, AKT1
17
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.7AKT3, AKT1, AKT2
18
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis60
9.7AKT2, AKT3, AKT1
199.7AKT1, AKT3, AKT2
209.7AKT2, AKT1, AKT3
219.7AKT1, AKT3, AKT2
22
Show member pathways
9.7AKT2, AKT3, AKT1
23
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.7AKT2, AKT3, AKT1
249.7AKT1, AKT2, AKT3
25
Show member pathways
DNA damage Role of SUMO in p53 regulation60
9.7AKT3, AKT2, AKT1
26
Show member pathways
9.7AKT1, AKT3, AKT2
279.7AKT3, AKT1, AKT2
28
Show member pathways
9.7AKT1, AKT2, AKT3
299.7AKT1, AKT3, AKT2
309.7AKT1, AKT3, AKT2
319.7AKT2, AKT1, AKT3
32
Show member pathways
9.7AKT3, AKT2, AKT1
33
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling60
9.7AKT2, AKT3, AKT1
349.7AKT1, AKT3, AKT2
359.7AKT2, AKT3, AKT1
369.7AKT2, AKT3, AKT1
379.7AKT3, AKT1, AKT2
38
Show member pathways
9.7AKT2, AKT1, AKT3
39
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.7AKT2, AKT3, AKT1
40
Show member pathways
9.4TNFRSF4, AKT2, AKT3, AKT1
41
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.2NKX2-1, AKT3, AKT2, AKT1
42
Show member pathways
9.1AKT2, AKT1, AKT3, RYR1
43
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
9.1RYR1, AKT1, AKT3, AKT2
44
Show member pathways
9.0AKT2, TNFRSF4, AKT1, CD2, AKT3
45
Show member pathways
9.0AKT3, AKT1, AKT2, TNFRSF4, CD2
46
Show member pathways
8.9AKT3, AKT1, AKT2, CTLA4
47
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.9AKT1, AKT2, AKT3, CTLA4
48
Show member pathways
8.9AKT1, AKT3, AKT2, CTLA4
49
Show member pathways
8.9AKT1, AKT3, AKT2, CTLA4
50
Show member pathways
8.6AKT3, AKT1, AKT2, CTLA4, AIRE

Compounds for genes affiliated with Thymoma

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Compounds related to Thymoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1sc 796110.1AKT1, AKT3, AKT2
2fpa 1246110.1AKT2, AKT3, AKT1
310-debc hydrochloride6110.1AKT2, AKT3, AKT1
4api-16110.0AKT2, AKT3, AKT1
5api-26110.0AKT1, AKT3, AKT2
6sodium iodide449.7NKX2-1, SSTR2
7sb 20358044 6110.7AIRE, AKT2, AKT1
8ouabain44 1110.6RYR1, AKT1
9con a449.3CTLA4, CD2
10gnrh449.3AKT1, SSTR2, NKX2-1
11tamoxifen44 50 28 1112.2AKT2, AKT1, SSTR2
12ly294002449.2CTLA4, AKT1, AKT3, AKT2
13ionomycin449.1CTLA4, CD2, TNFRSF4
14paraffin449.0AKT1, SSTR2, NKX2-1, CD5
15wortmannin449.0AKT2, AKT1, CD2, CTLA4
16rapamycin448.8AKT2, AKT1, CTLA4, RYR1
17phosphatidylinositol448.8CTLA4, AKT1, AKT3, AKT2
18threonine448.6AKT2, AKT3, AKT1, NKX2-1, CTLA4
19estrogen448.3AKT2, AKT1, SSTR2, NKX2-1, CTLA4
20lipid448.2AKT2, AKT3, AKT1, CD2, CTLA4, RYR1
21glucose448.0AKT2, AKT1, SSTR2, CD2, CTLA4, RYR1
22serine447.8AIRE, AKT2, AKT3, AKT1, NKX2-1, CTLA4
23tyrosine447.4AIRE, AKT2, AKT1, SSTR2, NKX2-1, CD2

GO Terms for genes affiliated with Thymoma

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Cellular components related to Thymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5CTLA4, CD5, CD2, TNFRSF4
2integral component of plasma membraneGO:0058877.1RYR1, TNFRSF4, SSTR2, CD2, CD5, CTLA4
3plasma membraneGO:0058866.4AKT2, AKT3, AKT1, SSTR2, CD2, CD5

Biological processes related to Thymoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of plasma membrane long-chain fatty acid transportGO:01074810.1AKT1, AKT2
2positive regulation of glucose metabolic processGO:01090710.1AKT1, AKT2
3peripheral nervous system myelin maintenanceGO:03228710.0AKT2, AKT1
4mammary gland epithelial cell differentiationGO:06064410.0AKT1, AKT2
5positive regulation of glucose importGO:04632610.0AKT1, AKT2
6positive regulation of glycogen biosynthetic processGO:0457259.9AKT1, AKT2
7glycogen biosynthetic processGO:0059789.7AKT1, AKT2
8T cell costimulationGO:0312959.1CTLA4, CD5, AKT1

Molecular functions related to Thymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:01630110.0AKT1, AKT2
2protein bindingGO:0055155.9RYR1, AIRE, AKT2, AKT3, AKT1, SSTR2

Products for genes affiliated with Thymoma

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  • Antibodies
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Sources for Thymoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet