Thymoma malady

Wikipedia: Thymoma is a tumor originating from the epithelial cells of the thymus. Thymoma is an uncommon tumor,...⁴⁴ more...

MalaCards: Thymoma, also known as thymoma nos (morphologic abnormality), is related to thymic carcinoma and dendritic cell thymoma. An important gene associated with Thymoma is AKT2 (v-akt murine thymoma viral oncogene homolog 2), and among its related pathways are Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR1 and Apoptosis and survival Role of CDK5 in neuronal death and survival. The compounds cholesterol and vitamin d have been mentioned in the context of this disorder. Affiliated tissues include thymus, small intestine and lung, and related mouse phenotypes are integument and vision/eye.

Aliases & Descriptions:

thymoma 6 8 32 43 thymoma nos (morphologic abnormality) 6

thymoma (morphologic abnormality) 6

Disease types for thymoma family:

type c thymoma

Diseases related to thymoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 956)

id	Related Disease	Score	Top Affiliating Genes
1	thymic carcinoma	31.9	KIT, VIM, BCL2, MUC1, CEACAM3, MSLN
2	dendritic cell thymoma	31.5	MSC, SLC4A3, HAVCR2
3	myasthenia gravis	30.4	VIP, VIPR1, BCL2, KCNA4, CHKB, MUSK
4	pure red-cell aplasia	28.8	PIK3C2A, CHGA, IL2, IFNA1, HLA-A, HLA-B
5	thymic epithelial tumor	28.5	KIT, BCL2, MUC1, CD5, MMP14, MMP2
6	lymphomatoid papulosis	28.0	B2M, JUNB, FAS, CCR3, TRG@, TRB@
7	primary hyperparathyroidism	27.6	CHGA, LBR, B2M, CALCA, PTHLH, SST
8	myotonic dystrophy	27.6	PIK3C2A, VIM, RAF1, BCL2, CHKB, ENO2
9	parathyroid adenoma	27.6	VIP, BCL2, CHGA, CALCA, PTHLH, TG
10	follicular dendritic cell sarcoma	27.4	VIM, EVPL, TP53, PPL, DSG3, DSP
11	dendritic cell sarcoma	27.4	VIM, EVPL, TP53, PPL, DSG3, DSP
12	limbic encephalitis	27.3	IFNG, AMPH, TPO, TG, GAD1
13	spiradenoma	27.3	TP53, KRT7, KRT14, DNTT
14	aplastic anemia	27.2	CD55, FAS, IFNG, TRB@, CYP2D6, CSF3
15	autoimmune thyroiditis	26.6	CHKB, CD55, IL12B, FAS, IFNG, CALCA
16	peripheral neuropathy	26.4	KCND3, MPO, IFNA1, IFNG, DMPK, NTRK1
17	myositis	25.4	PIK3C2A, VIM, BCL2, CHKB, MMP2, MMP9
18	hyperparathyroidism	25.0	VIP, VIPR1, CHGA, LBR, B2M, CDKN1A
19	pertussis	25.0	VIP, RAF1, CHGA, LBR, CD69, CD4
20	leukemia/lymphoma	24.8	BCL2, MUC1, XIAP, B2M, CGB, MPO
21	encephalitis	24.7	RAF1, BCL2, KCNH2, B2M, CD8A, CD4
22	pemphigus	24.3	MS4A1, IVL, MMP9, IL1A, IL1R1, IL1RAPL2
23	anemia	21.5	KIT, BCL2, CHGA, CHKB, LCK, B2M
24	carcinoma	21.5	PIK3C2A, KIT, RCVRN, VIM, VIP, VIPR1
25	neuropathy	20.6	PIK3C2A, VIM, VIP, KCNH2, KCND3, CHGA
26	lymphoblastic leukemia	20.3	KIT, BCL2, CHKB, LCK, LBR, XIAP
27	diabetes mellitus	19.1	PIK3C2A, VNN1, BCL2, CHGA, CHKB, MUSK
28	leukemia	18.8	PIK3C2A, KIT, RCVRN, VNN1, VIM, VIP
29	adenoma	17.7	KIT, VIM, VIP, VIPR1, RAF1, BCL2
30	thyroiditis	17.6	PIK3C2A, KIT, VIM, VIP, RAF1, BCL2
31	sarcoma	17.3	PIK3C2A, KIT, VIM, VIP, VIPR1, RAF1
32	pancreatitis	16.0	PIK3C2A, KIT, VNN1, VIM, VIP, VIPR1
33	neuronitis	15.2	PIK3C2A, KIT, RCVRN, VIM, VIP, VIPR1
34	ovarian small cell carcinoma	14.2	CALB2, PTHLH, DES, NKX2-1
35	diffuse infiltrative lymphocytosis syndrome	14.1	B2M, MS4A1, CD5, IL2, TRB@
36	juvenile rheumatoid arthritis	14.1	LBR, IL1A, IL1R1, IL1RAPL2, TRB@
37	schnitzler syndrome	14.0	IL18, IL1A, IL1R1, IL1RAPL2
38	mucinous cystadenocarcinoma	14.0	VIM, MUC1, CEACAM3, PTPRC, NKX2-1
39	centronuclear myopathy	14.0	CHKB, CDKN3, AMPH, TTN, DES, RYR1
40	pulmonary large cell neuroendocrine carcinoma	14.0	TP63, KRT7, KRT19, NKX2-1
41	neuroleptic malignant syndrome	14.0	PIK3C2A, CHKB, CYP2D6, RYR1, NMS
42	interstitial lung disease	14.0	LBR, IL1A, IL1R1, IL1RAPL2, EGFR, NKX2-1
43	episodic ataxia	14.0	KCND3, MUSK, ACHE, TTN, RYR1
44	parachordoma	14.0	VIM, MUC1, CEACAM3, KRT7, DES
45	rectum sarcomatoid carcinoma	14.0	VIM, MUC1, TP63, DES
46	polymorphous low-grade adenocarcinoma	14.0	KIT, VIM, CHKB, MUC1, CEACAM3, TP63
47	duchenne muscular dystrophy	14.0	PIK3C2A, CHKB, AQP4, TTN, DES, STS
48	bullous pemphigoid	14.0	IVL, IL7, EVPL, PPL, KRT14, DSG3
49	neuromuscular disease	14.0	CHKB, MUSK, DMPK, TTN, DES, RYR1
50	epithelioid leiomyosarcoma	14.0	VIM, ENO2, PTHLH, PTPRC, DES

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to thymoma:

²²

MGI Mouse Phenotypes related to thymoma:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	INF	KIT, RAF1, BCL2, MUC1, MUSK, LBR
2	vision/eye phenotype	MP:0005391	INF	KIT, RCVRN, VIM, RAF1, BCL2, MUC1
3	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, KIT, VNN1, VIM, VIP, VIPR1
4	cellular phenotype	MP:0005384	INF	KIT, VIM, VIPR1, RAF1, BCL2, ZBTB7B
5	digestive/alimentary phenotype	MP:0005381	INF	KIT, VIPR1, BCL2, MUC1, LBR, B2M
6	muscle phenotype	MP:0005369	INF	KIT, VIM, RAF1, BCL2, KCNH2, CHKB
7	normal phenotype	MP:0002873	INF	VIP, ZBTB7B, XIAP, , MSLN, CD2
8	endocrine/exocrine gland phenotype	MP:0005379	9.8	VIPR1, IL2, IFNG, AMPH, CACNA1B, GHR
9	hematopoietic system phenotype	MP:0005397	9.2	KIT, BCL2, ZBTB7B, XIAP, JUNB, CDKN1A
10	limbs/digits/tail phenotype	MP:0005371	8.9	KIT, CHKB, LBR, JUNB, MMP14, MMP9
11	liver/biliary system phenotype	MP:0005370	8.9	KIT, IL1R1, IL2, IFNG, AKT1, GHR
12	embryogenesis phenotype	MP:0005380	8.9	KIT, VIM, RAF1, KCNH2, LCK, FOS
13	renal/urinary system phenotype	MP:0005367	8.8	KIT, BCL2, CHGA, JUNB, CDKN1A, CD55
14	no phenotypic analysis	MP:0003012	8.3	ZBTB7B, MUC1, LBR, CD69, CD4, CD5
15	adipose tissue phenotype	MP:0005375	7.4	PIK3C2A, BCL2, LBR, CDKN1A, IL18, IL1R1
16	skeleton phenotype	MP:0005390	7.2	KIT, RAF1, MUSK, JUNB, CDKN1A, CD69
17	growth/size phenotype	MP:0005378	6.5	PIK3C2A, KIT, VNN1, VIPR1, RAF1, BCL2
18	behavior/neurological phenotype	MP:0005386	INF	KIT, VIM, VIP, VIPR1, KCNA4, CHKB
19	reproductive system phenotype	MP:0005389	INF	VIP, ZBTB7B, B2M, MMP14, MMP9, FOS
20	mortality/aging	MP:0010768	INF	PIK3C2A, VIPR1, KCNH2, MUSK, LBR, XIAP
21	immune system phenotype	MP:0005387	INF	KIT, VNN1, VIM, RAF1, ZBTB7B, LCK
22	respiratory system phenotype	MP:0005388	INF	MUSK, IL12B, AQP4, CALCA, TRD@, TP63
23	craniofacial phenotype	MP:0005382	INF	KIT, KCNH2, LBR, , IL12B, FBXW7
24	nervous system phenotype	MP:0003631	INF	KIT, RAF1, KCNA4, CHKB, LBR, CDKN1A
25	cardiovascular system phenotype	MP:0005385	INF	KIT, VIM, VIPR1, RAF1, BCL2, KCNH2
26	tumorigenesis	MP:0002006	INF	KIT, BCL2, MUC1, B2M, JUNB, CDKN1A
27	pigmentation phenotype	MP:0001186	INF	KIT, BCL2, FAS, TP53, PTEN, CYP19A1

Articles related to thymoma:

(show top 50)    (show all 161)

id	Title	Authors	Year	Affiliating Genes
1	Thymoma with nuclear expression of thyroid transcript ion factor-1: a potential diagnostic pitfall on core biopsy. (20823767)	Yan B.... Petersson F.	2011	NKX2-1
2	Rituximab treatment of stiff-person syndrome in a pat ient with thymoma, diabetes mellitus and autoimmune thyroiditis. (20071184)	Dupond J.L.... Hafsaoui C.	2010	GAD1, AMPH
3	Aquaporin-4 water channel expression by thymoma of pa tients with and without myasthenia gravis. (20728226)	Chan K.H.... Kung M.H.	2010	AQP4
4	Spiradenoma reminiscent of thymoma: report of a case and review of the literature. (18647207)	Levidou G.... Androulaki A.	2009	DNTT
5	Association of HLA-A in autoimmune myasthenia gravis with thymoma. (19278738)	Vandiedonck C.... Garchon H.J.	2009	HLA-A
6	Thymoma and thymic carcinoma arising in a thymolipoma: report of a unique case. (18480395)	Haddad H.... Sughayer M.	2009	KRT19
7	Case of agranulocytosis associated with thymoma (18318251)	Sato K.... Homma S.	2008	CSF3
8	Preferential expression of AChR epsilon-subunit in thymomas from patients with myasthenia gravis. (18657869)	Maclennan C.A.... Beeson D.	2008	CHRNE
9	Identifying alternative hyper-splicing signatures in MG-thymoma by exon arrays. (18545673)	Soreq L.... Soreq H.	2008	SRSF2
10	CRMP5 antibodies in patients with small-cell lung cancer or thymoma. (17657489)	Monstad S.E.... Vedeler C.A.	2008	DPYSL5
11	Common Cellular and Diverse Genetic Basis of Thymoma-associated Myasthenia Gravis: Role of MHC Class II and AIRE Genes and Genetic Polymorphisms. (18567864)	Strobel P.... Marx A.	2008	AIRE, CTLA4
12	The role of nuclear medicine in the management of thymomas. (18338540)	Treglia G.... Giordano A.	2007	SST
13	Hypereosinophilia in a patient with invasive thymoma with clonal T-lymphocyte expansion expressing CD4, CD8, and CD25 antigens. (16720555)	Sumi M.... Ohyashiki K.	2006	CD8A, IGES
14	Microscopic polyangiitis associated with thymoma, exacerbating after thymectomy. (17060003)	Parambil J.G.... Ryu J.H.	2006	MPO
15	The level of Bcl-2 and Fas expression in thymoma tissue from patients with myasthenia gravis (16750039)	Shen G.... Lin M.	2006	BCL2, FAS
16	Intestinal pseudo-obstruction as initial presentation of thymoma. (17090854)	Musthafa C.P.... Balakrishnan V.	2006	ACHE
17	Thymus CT scan and thymoma associated antibodies in myasthenia gravis with thymoma (16995304)	Li Y.F.... Cui L.Y.	2006	RYR1
18	Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma. (16574246)	Yoshikawa H.... Yamada M.	2006	IL12B
19	Rearrangement of T-cell receptor beta and gamma genes in thymoma. (15905344)	Nakajima J.... Takamoto S.	2005	TRB@, TRG@
20	Protein expression and gene amplification of epidermal growth factor receptor in thymomas. (15630697)	Ionescu D.N.... Dacic S.	2005	EGFR
21	Long-term disease-free survival of patients with radically resected thymomas: relevance of cell-cycle protein expression. (16206298)	Mineo T.C.... Baldi A.	2005	IFI27
22	Increased thymocyte CD4+CD8+ cells and T-cell receptor beta gene rearrangements in thymoma. (14621007)	Sakuraba M.... Ohnuki T.	2003	TRB@
23	Disease severity and outcome in thymoma myasthenia gravis: a long-term observation study. (14641516)	Romi F.... Aarli J.A.	2003	TTN, RYR1
24	Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis. (12653847)	Meager A.... Willcox N.	2003	IL18, IFNB1
25	Invasive thymoma with paraneoplastic retinopathy. (12874770)	Yamada G.... Abe S.	2003	RCVRN
26	Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in thymoma. (12616366)	Sasaki H.... Fujii Y.	2003	TYMS, DPYD
27	Autoantibodies to IL-12 in myasthenia gravis patients with thymoma; effects on the IFN-gamma responses of healthy CD4+ T cells. (12799027)	Zhang W.... Willcox N.	2003	IFNG
28	Titin and ryanodine receptor autoantibodies in dogs with thymoma and late-onset myasthenia gravis. (11182151)	Shelton G.D.... Aarli J.A.	2001	TTN, RYR1
29	Do titin and cytokine antibodies in MG patients predict thymoma or thymoma recurrence? (11706095)	Buckley C.... Vincent A.	2001	TTN, IFNA1
30	A case of myasthenia gravis accompanied by large thymoma and anti-GAD antibody (12080617)	Kitae S.... Nakamura S.	2001	GAD1
31	Cytokeratin profiles of the thymus and thymomas: histogenetic correlations and proposal for a histological classification of thymomas. (10792481)	Kuo T.	2000	CHKB
32	Heritable lympho-epithelial thymoma resulting from a transgene insertional mutation. (10644977)	Nakajima H.... Field L.J.	2000	THM
33	Effects of satratoxins and other macrocyclic trichothecenes on IL-2 production and viability of EL-4 thymoma cells. (10494915)	Lee M.G.... Pestka J.J.	1999	IL2
34	T-cell development in human thymoma. (10483584)	Inoue M.... Matsuda H.	1999	IL7
35	A giant invasive thymoma made resectable by cisplati n + vincristine + doxorubicin + etoposide (CODE) (10234303)	Hosokawa T.... Isobe H.	1999	CSF3
36	Expression of E-cadherin and alpha- and beta-catenins in thymoma. (9602713)	Pan C.C.... Wang L.S.	1998	CTNNA1
37	Differential regulation and transcriptional control of immediate early gene expression in forskolin-treated WEHI7.2 thymoma cells. (9544985)	Mao D.... Dowd D.R.	1998	FOS, JUNB, CREM
38	Diagnosis of thymoma and thymic atrophy in patients with myasthenia gravis (9441462)	Sund K.K.... Varhaug J.E.	1997	TTN
39	Malignant thymoma in a patient with HIV positivity: a case report with a review of the differential cytologic diagnoses. (9099551)	Fiorella R.M.... Kragel P.J.	1997	PTPRC
40	Detection of bcl-2 and p53 in thymoma: expression of bcl-2 as a reliable marker of tumor aggressiveness. (8892596)	Chen F.F.... Su I.J.	1996	TP53, BCL2
41	Effects of mycotoxins on cytokine production and proliferation in EL-4 thymoma cells. (8691508)	Marin M.L.... Pestka J.J.	1996	IL2
42	Effect of pertussis toxin and PGE2 on the functioning of the IL-2 promoter in interleukin-1 treated EL4.NOB-1 thymoma cells. (8674763)	McCarthy L.M.... O'Neill L.A.	1996	IL2
43	Intensive chemotherapy with cisplatin, doxorubicin, cyclophosphamide, etoposide and granulocyte colony-stimulating factor for advanced thymoma or thymic cancer: preliminary results. (7474409)	Oshita F.... Saijo N.	1995	CSF3
44	Thymomas express epitopes shared by the ryanodine receptor. (7499495)	Mygland A.... Gilhus N.E.	1995	RYR1
45	Recombinant glycosyl-phosphatidylinositol-anchored proteins are not associated with protein kinases in transfected thymoma cells. (7818491)	Clissold P.M.	1994	THY1
46	Concurrent invasive thymoma and T-cell lymphoblastic leukemia and lymphoma. A case report with necropsy findings and literature review of thymoma and associated hematologic neoplasm. (8160632)	Friedman H.D.... Poiesz B.J.	1994	TRB@
47	Anti-cardiac ryanodine receptor antibodies in thymoma -associated myasthenia gravis. (7948615)	Mygland A.... Gilhus N.E.	1994	RYR1, RYR2
48	Ryanodine receptor antibodies related to severity of thymoma associated myasthenia gravis. (8021674)	Mygland A.... Gilhus N.E.	1994	RYR1
49	Binding of human beta 2-microglobulin to murine EL4 thymoma cells upregulates MHC class I heavy-chain epitopes, inhibits IL-2 secretion and induces resistance to killing by natural killer cells. (7516913)	ClaAsson M.H.... Nissen M.H.	1994	IL2, B2M, HLA-B
50	Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells. (1988454)	Meier K.E.... Krebs E.G.	1991	CDKN3

Genes related to thymoma according to GeneCards:

(show top 50)    (show all 165)

id	Symbol	Description	Score	GeneCards Section Context
1	AKT2	v-akt murine thymoma viral oncogene homolog 2	11.0	Transcripts, Orthologs, Functions, Aliases & Descriptions
2	AKT1	v-akt murine thymoma viral oncogene homolog 1	11.0	Orthologs, Functions, Aliases & Descriptions, Transcripts
3	THM	thymoma	11.0	Aliases & Descriptions, Publications
4	AKT3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	11.0	Orthologs, Functions, Aliases & Descriptions, Transcripts
5	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
6	AIRE	autoimmune regulator	11.0	Publications
7	EVPL	envoplakin	11.0	Publications
8	TMSB4X	thymosin beta 4, X-linked	11.0	Publications
9	TTN	titin	11.0	Publications
10	THY1	Thy-1 cell surface antigen	11.0	Publications
11	TNFRSF4	tumor necrosis factor receptor superfamily, member 4	11.0
12	DNTT	deoxynucleotidyltransferase, terminal	11.0	Publications
13	CD5	CD5 molecule	11.0	Publications
14	SSTR2	somatostatin receptor 2	11.0	Publications
15	RYR1	ryanodine receptor 1 (skeletal)	11.0	Publications
16	NKX2-1	NK2 homeobox 1	11.0	Publications
17	DPYSL5	dihydropyrimidinase-like 5	11.0	Publications
18	PPL	periplakin	11.0	Publications
19	CD69	CD69 molecule	11.0	Publications
20	PRDX1	peroxiredoxin 1	11.0
21	CD2	CD2 molecule	11.0
22	PTMA	prothymosin, alpha	11.0
23	CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	11.0	Publications
24	DES	desmin	11.0	Publications
25	IL7	interleukin 7	11.0	Publications
26	LBR	lamin B receptor	11.0
27	NGFR	nerve growth factor receptor	11.0	Publications
28	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
29	CALB2	calbindin 2	11.0	Publications
30	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
31	CANX	calnexin	11.0
32	TP63	tumor protein p63	11.0	Publications
33	PTHLH	parathyroid hormone-like hormone	11.0	Publications
34	PTPRC	protein tyrosine phosphatase, receptor type, C	11.0	Publications
35	TRB@	T cell receptor beta locus	11.0	Publications
36	DSP	desmoplakin	11.0	Publications
37	MUC1	mucin 1, cell surface associated	11.0	Publications
38	LCK	lymphocyte-specific protein tyrosine kinase	11.0	Publications
39	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0
40	TXN	thioredoxin	11.0	Publications
41	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	11.0
42	IL2	interleukin 2	11.0	Publications
43	PRKCE	protein kinase C, epsilon	11.0	Publications
44	IL1A	interleukin 1, alpha	11.0	Publications
45	IL1R1	interleukin 1 receptor, type I	11.0
46	SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	11.0
47	PRKCA	protein kinase C, alpha	11.0
48	IL1RAPL2	interleukin 1 receptor accessory protein-like 2	11.0
49	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	11.0
50	AKTIP	AKT interacting protein	10.9	Orthologs

Pathways related to thymoma according to GeneDecks:

(show top 50)    (show all 229)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR141	11.1	PRKCA, AKT1, AKT2, AKT3, PRKCE
2	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.7	AKT3, NTRK1, BCL2
3	Development VEGF signaling and activation10	10.7	RAF1, FOS, AKT3, SRC, PRKCE, PRKCD
4	Development VEGF signaling via VEGFR2 - generic cascades10	10.7	PRKCA, RAF1, FOS, AKT1, AKT2, AKT3
5	Signal transduction Erk Interactions- Inhibition of Erk10	10.7	AKT1, LCK, GMFB, PRKCD, PRKCE, TRB@
6	Adipocytokines & Insulin Signaling37	10.6	PRKCD, AKT3, KRAS, FOS, PRKCE, PRKCA
7	VEGF Signaling Pathway34	10.5	PRKCE, AKT2, PRKCA, PRKCD, KRAS, PIK3C2A
8	Hematopoietic cell lineage20	10.5	CD55, IL1A, IL1R1, IL7, TPO, DNTT
9	EGF Pathway36	10.5	EGFR, PRKCE, PRKCD, AKT1, PRKCA, SRC
10	Signal transduction PTEN pathway10	10.4	AKT3, RAF1, SRC, PTEN, CDKN1A, AKT1
11	Jak-STAT signaling pathway20	10.4	IFNB1, TPO, IL12B, IL2, IL7, IFNA1
12	Development_Growth hormone signaling via PI3K/AKT and MAPK cascades41	10.4	JUNB, GHR, FOS, AKT2, AKT3, SRC
13	Development_VEGF signaling and activation41	10.3	FOS, RAF1, AKT2, AKT3, AKT1, ESR1
14	Endothelin-1 Signaling Pathway36	10.2	CSF3, IL2, IL7, SRC, PRKCD, NTRK1
15	Development Prolactin receptor signaling10	10.2	AKT3, PRLR, NR3C1, SRC, AKT2, BCL2
16	Development_Prolactin receptor signaling41	10.2	RAF1, PRKCD, NR3C1, PRLR, SRC, AKT3
17	Non-small cell lung cancer20	10.2	PRKCA, KRAS, AKT3, AKT2, AKT1, FHIT
18	Development Growth hormone signaling via PI3K/AKT and MAPK cascades10	10.2	RAF1, JUNB, FOS, AKT1, AKT2, AKT3
19	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	10.1	BCL2, AKT2, AKT1, RAF1, TP53, NTRK1
20	Development_EGFR signaling pathway41	10.1	MMP9, RAF1, MMP2, FOS, AKT1, AKT2
21	cAMP Pathway36	10.0	AKT2, AKT1, SRC, CACNA1B, RAF1, KIT
22	ErbB signaling pathway20	10.0	ABL2, EGFR, KRAS, SRC, AKT2, AKT3
23	STAT3 Pathway36	9.9	BCL2, IL18, IL12B, CD4, CD2, CDKN1A
24	Tec Kinases Signaling36	9.9	CD2, CD4, IL7, IL1A, IL1R1, PRKCA
25	14-3-3 Induced Intracellular Signaling36	9.8	PRKCA, PRKCD, PRKCE, PDGFRA, NTRK1, SRC
26	Glucocorticoid Receptor Signaling36	9.8	IL18, NGFR, SMARCC1, NR3C1, IL7, IL2
27	PTEN Pathway36	9.8	EGFR, PRKCD, PRKCE, TP53, PDGFRA, PDGFA
28	ERK Signaling36	9.8	IL7, IL18, CD2, MUSK, RAF1, KIT
29	p53 Mediated Apoptosis36	9.8	KIT, BCL2, AKT2, NTRK1, AKT3, PTEN
30	Apoptosis20	9.8	BCL2, IL1A, AKT2, IL1R1, TP53, FAS
31	T cell receptor signaling pathway20	9.8	KRAS, CTLA4, PTPRC, AKT3, AKT2, RAF1
32	UVC-Induced MAPK Signaling36	9.7	EGFR, PRKCE, PRKCD, SRC, TP53, FOS
33	Endometrial cancer20	9.7	EGFR, KRAS, CTNNA1, PTEN, AKT2, AKT1
34	Antioxidant Action of Vitamin-C36	9.7	CCR3, CD2, KIT, BCL2, CD4, FOS
35	Mitochondrial Apoptosis36	9.7	TP53, KIT, BCL2, IL2, PRKCA, NTRK1
36	Glioblastoma Multiforme36	9.6	PTEN, EGFR, PRKCD, CDKN1A, AKT1, AKT2
37	Glioma20	9.6	KRAS, PRKCA, EGFR, PDGFRA, PDGFA, RAF1
38	Melanoma20	9.5	PTEN, PDGFA, KRAS, EGFR, PDGFRA, TP53
39	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.5	CYP19A1, PRKCA, IL1A, CALCA, PRKCD, PRKCE
40	Akt Signaling36	9.4	AKT1S1, NGFR, PDGFRA, PDGFA, AKT1, CCR3
41	p38 Signaling36	9.4	LCK, IL2, KIT, BCL2, MUSK, SRC
42	MAPK signaling pathway20	9.3	RAF1, FOS, TP53, IL1A, IL1R1, CACNA1B
43	Prostate cancer20	9.3	BCL2, AKT1, AKT2, AKT3, TP53, PTEN
44	ILK Signaling36	9.3	PTGS2, NTRK1, PDGFA, PDGFRA, EGFR, TMSB4X
45	Type I diabetes mellitus20	9.1	IL1A, IL12B, GAD1, IL2, FAS, IFNG
46	Molecular Mechanisms of Cancer36	9.0	RAF1, BCL2, MUSK, CDKN1A, IL7, CTNNA1
47	Cytokine-cytokine receptor interaction20	8.9	IL1A, IL18, IL12B, KIT, GHR, PDGFRA
48	Pancreatic Adenocarcinoma36	8.8	MMP9, MMP2, CDKN1A, PDGFRA, RAF1, BCL2
49	JAK-STAT Pathway36	8.7	GHR, NGFR, PDGFA, PDGFRA, EGFR, PRLR
50	Pathways in cancer20	8.6	FAS, BCL2, CDKN1A, FOS, MMP9, MMP2

Compounds related to thymoma according to GeneDecks:

(show top 50)    (show all 416)

id	Compound	Score	Top Affiliating Genes
1	cholesterol32 9 18 9	INF	PIK3C2A, CHGA, CHKB, MUC1, LBR, B2M
2	vitamin d32	INF	VIM, CHGA, CHKB, LBR, B2M, JUNB
3	cysteine32	INF	RCVRN, RAF1, CHKB, MUC1, LCK, LBR
4	hematoxylin32	INF	KIT, VIM, CHGA, MUC1, CEACAM3, MS4A1
5	calcium32 9 18 9	INF	PIK3C2A, KIT, RCVRN, VIP, VIPR1, KCNA4
6	paraffin32	INF	KIT, VIM, BCL2, CHGA, CHKB, MUC1
7	tyrosine32	INF	PIK3C2A, KIT, VNN2, VIP, VIPR1, RAF1
8	gnrh32	10.6	VIM, RAF1, CGB, JUNB, CD69, AKT1
9	agar32	10.2	VIM, MUC1, XIAP, MMP14, FHIT, IL7
10	vincristine32 34 9 9	13.1	KIT, CGB, IFNA1, IFNB1, CALCA, TXN
11	glycogen32 18	10.9	PIK3C2A, KIT, VIM, CHGA, CHKB, CDKN3
12	ly29400232	9.7	PIK3C2A, CD69, CDKN3, MMP14, MMP2, MMP9
13	atp32	9.5	PIK3C2A, KIT, CHKB, LCK, LBR, JUNB
14	norepinephrine32 9 18 9	12.5	PIK3C2A, VIP, CHGA, CHKB, LBR, JUNB
15	epinephrine32 9 18 9	12.4	PIK3C2A, VIP, CHGA, CHKB, LBR, CD69
16	rapamycin32 42	10.4	KIT, VIM, RAF1, IL1R1, IL2, IFNG
17	estradiol32 9 18 9	12.4	VIM, CHKB, MUC1, XIAP, CGB, IL18
18	nitric oxide32 9 18 9	12.2	KIT, VIPR1, CHGA, CHKB, MUC1, CEACAM3
19	dopamine32 9 18 9	12.2	VIP, RAF1, KCNA4, CHKB, MMP9, FOS
20	acetylcholine32 9 18 9	12.0	PIK3C2A, VIM, VIP, RAF1, CHGA, MUSK
21	aspartate32	9.0	PIK3C2A, VIM, VIP, RAF1, CHKB, B2M
22	ribonucleic acid32	8.8	KIT, CHGA, MUC1, MMP14, MMP2, MMP9
23	n acetylcysteine32	8.6	RAF1, CDKN1A, MMP2, MMP9, FOS, FHIT
24	etoposide32 42 9 9	11.6	BCL2, CHGA, XIAP, CGB, CDKN1A, CDKN3
25	creatinine32	8.6	KCNH2, CHGA, MUC1, B2M, CGB, CEACAM3
26	adriamycin32	8.6	VIM, BCL2, MUC1, XIAP, B2M, CEACAM3
27	glutamate32	8.4	VIM, VIP, LCK, XIAP, JUNB, CD4
28	arsenite32 18	9.3	BCL2, KCNH2, LBR, XIAP, CDKN1A, CDKN3
29	cytarabine32 34 9 9	11.2	KIT, VIM, BCL2, MUC1, XIAP, MPO
30	indomethacin32 9 9	10.0	VIM, VIP, RAF1, B2M, MPO, CDKN3
31	gemcitabine32 34 9 9	10.3	BCL2, MUC1, XIAP, CDKN1A, MMP2, IFNB1
32	testosterone32 9 18 9	10.1	PIK3C2A, KIT, VIM, VIP, RAF1, KCNH2
33	actinomycin d32	6.7	KIT, VIM, VIPR1, BCL2, MUC1, XIAP
34	cycloheximide32	4.5	KIT, VIM, RAF1, BCL2, CHGA, LCK
35	methionine32	INF	KIT, VIM, KCNH2, CHGA, LBR, FHIT
36	gold32	INF	PIK3C2A, KIT, CHGA, MUC1, LBR, CEACAM3
37	tamoxifen32 34 9 9	INF	VIM, RAF1, BCL2, CHGA, CHKB, MUC1
38	methotrexate32 34 42 9 9	INF	PIK3C2A, KIT, VIM, CHKB, MUC1, CGB
39	arginine32	INF	PIK3C2A, VIP, KCNH2, CHGA, CHKB, LBR
40	adenylate32	INF	VIM, VIP, VIPR1, KCNH2, CHGA, CHKB
41	alanine32	INF	PIK3C2A, VIP, VIPR1, RAF1, KCNH2, CHKB
42	lactate32	INF	PIK3C2A, KIT, VIM, VIP, CHGA, CHKB
43	5fluorouracil32	INF	KIT, BCL2, MUC1, XIAP, CEACAM3, MPO
44	thymidine32 18	INF	VIP, RAF1, KCNH2, CHKB, MUC1, LBR
45	oxygen32 18	INF	PIK3C2A, BCL2, CHKB, LCK, XIAP, CEACAM3
46	curcumin32	INF	RAF1, BCL2, XIAP, CDKN1A, , MMP14
47	calcitriol32 42 9 18 9	INF	XIAP, B2M, JUNB, CDKN1A, , MMP14
48	pge232	INF	VIP, RAF1, JUNB, CD69, CD4,
49	phosphatidylinositol32	INF	PIK3C2A, KIT, RAF1, BCL2, LCK, XIAP
50	pd 98,05932	INF	KIT, RAF1, BCL2, XIAP, JUNB, CDKN1A

Cellular components related to thymoma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	INF	PPL, NR3C1, SMARCC1, CREM, NOB1, SRSF2
2	cytoplasm	GO:005737	INF	KRT7, WT1, PDGFRA, NR3C1, SSTR2, SULT1E1
3	cell surface	GO:009986	9.7	NGFR, PDGFA, SHH, THBD, PRLR, ADA
4	membrane raft	GO:045121	9.6	SHH, EGFR, THY1, PRKCA, KRAS, PTPRC
5	external side of plasma membrane	GO:009897	9.4	IFNG, TNFRSF4, PTPRC, CTLA4, THY1, ADA
6	protein complex	GO:043234	8.7	DPYSL5, SYP, PRKCA, RYR2, DPYSL2, NR3C1
7	extracellular region	GO:005576	8.5	TMSB4X, TXN, GHR, CALCA, IFNG, IFNB1
8	extracellular space	GO:005615	8.2	CALCA, GHR, PTHLH, SST, PDGFA, SHH
9	integral to plasma membrane	GO:005887	INF	NTRK1, CTLA4, SSTR2, PTPRC, TNFRSF4, TPO
10	plasma membrane	GO:005886	INF	CHRNE, SHH, KRAS, PDPN, PDGFRA, NGFR
11	cytosol	GO:005829	INF	DSG3, THY1, TTN, TYMS, ABL2,
12	membrane	GO:016020	INF	EGFR, ACHE, STK16, STS, SLC2A1,

Biological processes related to thymoma according to GeneDecks:

(show all 48)

id	Name	GO ID	Score	Top Affiliating Genes
1	skin development	GO:043588	10.8	NGFR, PDGFA, SHH, DSP, STS, RYR1
2	platelet activation	GO:030168	10.8	PRKCA, PRKCD, PRKCE, TTN, PDGFA, SRC
3	release of sequestered calcium ion into cytosol	GO:051209	10.6	RYR2, RYR1, PRKCE, PTPRC, LCK
4	natural killer cell activation	GO:030101	10.6	IFNB1, IL2, IL12B, CD2
5	response to interleukin-1	GO:070555	10.6	ETS1, GHR, SRC, PRKCA, IL1R1
6	pyrimidine nucleobase catabolic process	GO:006208	10.6	DPYSL5, DPYSL4, DPYSL2, DPYD
7	positive regulation of B cell proliferation	GO:030890	10.6	ADA, PTPRC, TNFRSF4, IL7, IL2, CDKN1A
8	regulation of peptidyl-tyrosine phosphorylation	GO:050730	10.6	PRKCA, PRKCE, EGFR, PDGFA
9	T cell differentiation	GO:030217	10.5	PTPRC, PTPN22, IL2, CD4, LCK, KIT
10	B cell proliferation	GO:042100	10.5	PRKCD, PTPRC, IFNB1, BCL2
11	cell-cell signaling	GO:007267	10.5	SHH, PDGFA, SSTR2, SST, PTHLH, TXN
12	protein phosphorylation	GO:006468	10.4	NTRK1, PRKCE, PRKCD, PRKCA, RUNX3, DMPK
13	axon guidance	GO:007411	10.4	NKX2-1, RUNX3, DPYSL5, DPYSL4, DPYSL2, ABL2
14	cell-cell adhesion	GO:016337	10.4	DSP, THY1, EGFR, PDPN, CD2, BCL2
15	response to corticosterone stimulus	GO:051412	10.3	PRKCA, NR3C1, CDKN1A, JUNB, BCL2
16	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	10.3	GHR, IL2, IL12B, KIT
17	T cell costimulation	GO:031295	10.3	LCK, CD4, CD5, AKT1, SRC, CTLA4
18	response to radiation	GO:009314	10.2	NR3C1, TXN, IL18, MMP9, BCL2, KIT
19	induction of apoptosis	GO:006917	10.2	RUNX3, PRKCE, WT1, PTEN, TP63, ETS1
20	response to organic cyclic compound	GO:014070	10.2	PRKCA, STS, CTNNA1, PTGS2, ENO2, IL1A
21	lymphoid progenitor cell differentiation	GO:002320	10.2	SHH, BCL2, KIT
22	activation of pro-apoptotic gene products	GO:008633	10.2	NMT1, AKT1, IFI27, FAS, BCL2
23	response to hyperoxia	GO:055093	10.2	PDPN, IL18, MMP9, CDKN1A
24	blood coagulation	GO:007596	10.1	PRKCA, SLC7A5, PRKCD, PRKCE, RAF1, LCK
25	immune response	GO:006955	10.1	AIRE, HLA-A, HLA-B, TNFRSF4, CTLA4, CSF3
26	anti-apoptosis	GO:006916	10.1	ETS1, AKT1, NR3C1, NGFR, PRLR, FAS
27	positive regulation of cell proliferation	GO:008284	10.0	PDGFRA, KRAS, SHH, EGFR, STS, CSF3
28	induction of apoptosis by intracellular signals	GO:008629	9.9	NMT1, PRKCA, TP53, AKT1, CDKN1A, XIAP
29	inflammatory response	GO:006954	9.9	PDPN, PTGS2, TNFRSF4, AKT1, CALCA, CCR3
30	positive regulation of fibroblast proliferation	GO:048146	9.9	EGFR, PDGFRA, PDGFA, NGFR, CDKN1A
31	response to estrogen stimulus	GO:043627	9.8	STS, KRT19, CTNNA1, ESR1, FAS, BCL2
32	nerve growth factor receptor signaling pathway	GO:048011	9.7	AKT1, AKT1S1, PTEN, SRC, NTRK1, NGFR
33	cellular component movement	GO:006928	9.7	PDPN, PTGS2, TXN, AMFR, IFNG, VIM
34	neuron apoptotic process	GO:051402	9.7	GAPDH, TP63, TP53, FAS, BCL2
35	fibroblast growth factor receptor signaling pathway	GO:008543	9.7	PRKCA, PRKCD, PRKCE, KRAS, SRC, PTEN
36	phosphatidylinositol-mediated signaling	GO:048015	9.6	TYMS, PDGFRA, NTRK1, PTEN, AKT1S1, AKT1
37	response to hypoxia	GO:001666	9.6	RAF1, BCL2, MMP9, IL18, IL1A, FAS
38	response to estradiol stimulus	GO:032355	9.4	PRKCA, SHH, CYP19A1, PTGS2, GHR, ESR1
39	cytokine-mediated signaling pathway	GO:019221	9.4	CSF3, KIT, B2M, IL1A, IFI27, IFNB1
40	humoral immune response	GO:006959	9.4	AIRE, IFNG, IFNB1, IL7, BCL2
41	epidermal growth factor receptor signaling pathway	GO:007173	9.4	EGFR, PRKCE, PRKCD, PRKCA, KRAS, SRC
42	cell surface receptor signaling pathway	GO:007166	9.4	PRLR, EGFR, SST, PTPRC, IFNG, IFNB1
43	negative regulation of apoptotic process	GO:043066	9.3	SHH, EGFR, WT1, CTNNA1, RAF1, BCL2
44	signal transduction	GO:007165	9.2	CHRNE, NR3C1, CREM, PDPN, EGFR, ABL2
45	positive regulation of nitric oxide biosynthetic process	GO:045429	9.1	EGFR, PTGS2, ESR1, AKT1, IFNG
46	negative regulation of cell proliferation	GO:008285	9.1	PTHLH, SST, SSTR2, NTRK1, WT1, PRKCA
47	apoptotic process	GO:006915	8.8	TP63, TNS4, PTEN, NGFR, SHH, DSG3
48	response to drug	GO:042493	8.4	IFNG, PTGS2, CYP19A1, SST, DPYSL2, GAD1

Molecular functions related to thymoma according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein tyrosine kinase activity	GO:004713	10.3	TTN, ABL2, EGFR, SRC, LCK, MUSK
2	transmembrane receptor protein tyrosine kinase activity	GO:004714	10.1	EGFR, PDGFRA, NTRK1, MUSK, KIT
3	transmembrane signaling receptor activity	GO:004888	9.9	CD69, CD4, CD5, IL1R1, NGFR, EGFR
4	protease binding	GO:002020	9.9	RYR1, TTN, TP53, IL1R1, BCL2, KIT
5	nitric-oxide synthase regulator activity	GO:030235	9.6	EGFR, ESR1, AKT1
6	identical protein binding	GO:042802	8.5	TP63, EGFR, TTN, SYP, PRDX1, SLC2A1
7	enzyme binding	GO:019899	8.5	CSF3, PRKCA, PRKCD, PRKCE, TTN, EGFR
8	protein homodimerization activity	GO:042803	8.5	PRLR, DPYD, ACHE, PDGFRA, PDGFA, NR3C1
9	protein binding	GO:005515	INF	TP53, CTNNA1, NTRK1, PPL, NR3C1, SMARCC1