MCID: THY023
MIFTS: 66

Thymoma malady

Cancer diseases category

Summaries for Thymoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Thymoma is a tumor originating from the epithelial cells of the thymus. Thymoma is an uncommon tumor,... more...

MalaCards: Thymoma, also known as primary thymic epithelial neoplasm, is related to myasthenia gravis and leukemia, and has symptoms including alopecia, peritoneal diseases and bone marrow failure/pancytopenia. An important gene associated with Thymoma is AKT2 (v-akt murine thymoma viral oncogene homolog 2), and among its related pathways are Akt Signaling and G-protein signaling G-Protein alpha-i signaling cascades. The compounds tyrosine and lipid have been mentioned in the context of this disorder. Affiliated tissues include thymus, t cells and lung, and related mouse phenotypes are cellular and normal.

Description from OMIM:46 274230

Aliases & Classifications for Thymoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
thymoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

thymoma 8 10 44 48 46 60
primary thymic epithelial neoplasm 48
primary thymic epithelial tumor 48
thymoma nos 8


External Ids:

Disease Ontology8 DOID:3275
MeSH34 D013945
NCIt39 C3411
SNOMED-CT via Orphanet57 128856005, 444231005
UMLS via Orphanet61 C0040100
OMIM46 274230
MESH via Orphanet35 D013945
ICD10 via Orphanet26 C37, D15.0

Related Diseases for Thymoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Thymoma family:

Malignant Type a Thymoma Malignant Type Ab Thymoma
Type C Thymoma Thymoma Type a
Thymoma Type B Thymoma Type Ab

Diseases related to Thymoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1myasthenia gravis31.3TNFRSF4, AIRE, RYR1
2leukemia30.4IFI27, TNFRSF4, AKT1, DNTT, CD5, CD2
3epithelial malignant thymoma30.3SLC4A3, HAVCR2
4lung cancer30.1IFI27, AKT2, NKX2-1, DPYSL5
5sarcoma30.0SSTR2, THY1, EVPL
6hepatitis30.0AIRE
7melanoma29.9IFI27, TNFRSF4, AKT1, AKT3, NKX2-1, SSTR2
8thymus cancer29.9CD5, NKX2-1
9tuberculosis29.9CD69
10papillary carcinoma29.9IFI27, NKX2-1, SSTR2
11graves' disease29.7TNFRSF4, NKX2-1, AIRE, CD69
12adenocarcinoma29.7IFI27, AKT1, AKT2, NKX2-1, SSTR2
13hodgkin's lymphoma29.7MSC
14neuroendocrine tumor29.7SSTR2, NKX2-1, IFI27
15breast cancer29.7IFI27, AKT1, AKT2, NKX2-1, SSTR2
16thymic carcinoma10.7
17pure red-cell aplasia10.6
18pemphigus10.5
19cervicitis10.4
20encephalitis10.4
21mediastinitis10.4
22good syndrome10.4
23spindle cell thymoma10.4
24combined thymoma10.4
25cortical thymoma10.3
26myocarditis10.3
27candidiasis10.3
28invasive malignant thymoma10.3
29thyroiditis10.3
30lichen planus10.3
31chronic mucocutaneous candidiasis10.2
32stiff-person syndrome10.2
33spindle cell carcinoma10.2
34encapsulated thymoma10.2
35intestinal obstruction10.2
36intestinal pseudo-obstruction10.2
37lupus erythematosus10.2
38myositis10.2
39systemic lupus erythematosus10.1
40dendritic cell thymoma10.1
41dermatitis10.1
42lymphoblastic leukemia10.1
43mixed type thymoma10.1
44type c thymoma10.1
45graft versus host disease10.1
46noninvasive malignant thymoma10.1
47pancytopenia10.1
48malignant type a thymoma10.1
49malignant type ab thymoma10.1
50predominantly cortical thymoma10.1

Graphical network of the top 20 diseases related to Thymoma:



Diseases related to thymoma

Clinical Features for Thymoma

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

274230

Clinical synopsis from OMIM:

274230

Symptoms:

48 (show all 35)
  • alopecia
  • peritoneal diseases
  • bone marrow failure/pancytopenia
  • xerophthalmia/dry eyes
  • mediastinal anomalies
  • lymphocytes anomalies
  • asthenia/fatigue/weakness
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • myasthenia
  • thymus/thymic neoplasm/tumor/carcinoma/cancer/thymoma
  • myositis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • cough
  • thoracic/chest pain
  • mouth dryness/xerostomia
  • cutaneous rash
  • restricted joint mobility/joint stiffness/ankylosis
  • arthritis/synovitis/synovial proliferation
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • ptosis
  • myocardium anomalies/myocarditis
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • cushingoid morphotype
  • lymphadenopathy/polyadenopathies
  • bone/osseous neoplasm/tumor/carcinoma/cancer
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • thymic aplasia/hypoplasia
  • thyroiditis
  • nephrotic syndrome
  • agammaglobulinemia/hypogammaglobulinemia/b-cell deficiency
  • hemolytic anemia
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • diplopia/double vision

Drugs & Therapeutics for Thymoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Thymoma

Drug clinical trials:

Search ClinicalTrials for Thymoma

Search NIH Clinical Center for Thymoma

Search CenterWatch for Thymoma

Genetic Tests for Thymoma

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Anatomical Context for Thymoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Thymoma:

32
Thymus, T cells, Lung, Thyroid, Bone, B cells, Liver, Bone marrow, Eye, Brain, Breast, Skin, Testes, Lymph node, Placenta, Heart, Endothelial, Pituitary, Colon

Animal Models for Thymoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Thymoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.2AKT2, AKT3, AKT1, HAVCR2, TNFRSF4, NKX2-1
2MP:000287311.1MSC, TNFRSF4, AKT1, AKT3, AKT2, AIRE
3MP:000538810.9TNFRSF4, AKT1, AKT2, NKX2-1, AIRE, RYR1
4MP:000539710.9TNFRSF4, HAVCR2, AKT1, AKT3, AKT2, AIRE
5MP:000538710.8TNFRSF4, HAVCR2, AKT1, AKT3, AKT2, AIRE
6MP:000538110.8MSC, RYR1, AIRE, SSTR2, NKX2-1, TNFRSF4
7MP:000363110.4NKX2-1, SSTR2, AIRE, DPYSL5, SLC4A3

Publications for Thymoma

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Sources:
50PubMed
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Articles related to Thymoma:

(show top 50)    (show all 869)
idTitleAuthorsYear
1
Late distant metastases of malignant thymoma associated with peripheral T-cell lymphocytosis. (24147431)
2013
2
Giant cell polymyositis and myocarditis associated with myasthenia gravis and thymoma. (22989101)
2013
3
Evaluation of the role of radiation therapy in the management of malignant thymoma. (21596484)
2012
4
Pulmonary metastasis from encapsulated cervical ectopic type a thymoma. (23176955)
2012
5
Aortic pseudoaneurysm due to graft infection after invasive thymoma resection. (23087306)
2012
6
Metaplastic thymoma of the mediastinum. A clinicopathologic, immunohistochemical, and genetic analysis. (22261452)
2012
7
An interesting collection of paraneoplastic syndromes in a patient with a malignant thymoma. (22761203)
2012
8
Thymoma-a clinico-pathological long-term study with emphasis on histology and adjuvant radiotherapy dose. (23154559)
2012
9
Long-term results of thoracoscopic thymectomy for thymoma without myasthenia gravis. (23206481)
2012
10
Ectopic thymoma presenting as a giant intrathoracic mass: a case report. (22800398)
2012
11
Thymoma and myasthenia gravis: clinical aspects and prognosis. (22371942)
2012
12
Does surgical debulking for advanced stages of thymoma improve survival? (22700684)
2012
13
Protein expression status of p53 and epidermal growth factor receptor in thymoma. (22866103)
2011
14
Prolonged survival in advanced thymoma: Effectiveness of sequential multiple lines of chemotherapy in an inoperable case. (22866110)
2011
15
Ectopic cervical thymoma in a patient with myasthenia gravis. (21733179)
2011
16
Standard report terms for chest computed tomography reports of anterior mediastinal masses suspicious for thymoma. (21847053)
2011
17
Spontaneous regression of an invasive thymoma. (20401719)
2010
18
Staging system of thymoma. (20859124)
2010
19
Acquired autoimmune polyglandular syndrome, thymoma, and an AIRE defect. (20181983)
2010
20
Fulminant giant cell myocarditis and cardiogenic shock: an unusual presentation of malignant thymoma. (20454573)
2010
21
Comparison of patterns of relapse in thymic carcinoma and thymoma. (19577051)
2009
22
Lymphoepithelial thymoma characterized by proliferation of spindle cells in a Samoyed dog. (19801913)
2009
23
Multimodality therapy for patients with invasive thymoma disseminated into the pleural cavity: the potential role of extrapleural pneumonectomy. (19699926)
2009
24
Post pericardiocentesis low cardiac output syndrome in a patient with malignant thymoma. (21686351)
2009
25
What is your diagnosis? Thymoma. (19210251)
2009
26
Tumours and tumour-like conditions of the thymus other than thymoma; a practical approach. (19054157)
2009
27
Association between thymoma and autoimmune enteropathy in adults. (16996380)
2006
28
Chronic mucocutaneous candidiasis associated with malignant thymoma and systemic lupus erythematosus with hypergammaglobulinemia: a case report and literature review. (16903322)
2006
29
Thymoma-associated exfoliative dermatitis in a rabbit. (16101800)
2005
30
Thymoma and thymic carcinoma: an update of the WHO Classification 2004. (16175459)
2005
31
Triad of thymoma, myasthenia gravis and pure red cell aplasia combined with SjAPgren's syndrome. (15296032)
2004
32
Clinical-pathologic conference: cutaneous paraneoplastic pemphigus associated with benign encapsulated thymoma. (12579111)
2003
33
A case of nonspecific interstitial pneumonia associated with thymoma. (12737285)
2003
34
Concurrent epithelial thymoma and T-cell lymphoblastic lymphoma. (17670116)
2003
35
Pure red cell aplasia associated with thymoma. (12437240)
2002
36
Surgical treatment of thymoma. (16093116)
2002
37
Ets-1 gene expression in patients with thymoma. (12561090)
2002
38
Thymoma and pancytopenia: a very rare association. (12091142)
2002
39
Recurrent genetic aberrations in thymoma and thymic carcinoma. (10880395)
2000
40
Thymoma-associated autoimmune enteropathy. A report of two cases. (10587704)
1999
41
Thrombotic thrombocytopenic purpura accompanied by transient pure red cell aplasia and thymoma. (9543602)
1998
42
Association of ocular toxoplasmosis and thymoma. (9279956)
1997
43
Effect of pertussis toxin and PGE2 on the functioning of the IL-2 promoter in interleukin-1 treated EL4.NOB-1 thymoma cells. (8674763)
1996
44
Limbic encephalitis and immunological perturbations in two patients with thymoma. (7608671)
1995
45
Recombinant glycosyl-phosphatidylinositol-anchored proteins are not associated with protein kinases in transfected thymoma cells. (7818491)
1994
46
Structural characterization of free glycolipids which are potential precursors for glycophosphatidylinositol anchors in mouse thymoma cell lines. (1429614)
1992
47
Patients with myasthenia gravis and thymoma have in their sera IgG autoantibodies against titin. (2242609)
1990
48
Effectiveness of interleukin-2 in invasive lymphoepithelial thymoma. (1972505)
1990
49
Severe diarrhea controlled by gamma globulin in a patient with agammaglobulinemia, amyloidosis, and thymoma. (4161743)
1966
50
BENIGN THYMOMA, REFRACTORY ANEMIA AND HYPOGAMMAGLOBULINEMIA--CASE REPORT. (14278243)
1965

Genetic Variations for Thymoma

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Expression for genes affiliated with Thymoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thymoma

Search GEO for disease gene expression data for Thymoma.

Pathways for genes affiliated with Thymoma

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Sources:
51QIAGEN, 12EMD Millipore, 55SinoBiological, 52R&D Systems, 53Reactome, 29KEGG, 59Tocris Bioscience, 37NCBI BioSystems Database, 4Cell Signaling Technology, 49PharmGKB
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Pathways related to Thymoma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7AKT2, CD2, AKT1, TNFRSF4, AKT3
2
G-protein signaling G-Protein alpha-i signaling cascades
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10.7RYR1, AKT2, AKT1, AKT3
3
Cell adhesion Integrin-mediated cell adhesion and migration
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10.7NKX2-1, AKT1, AKT2, AKT3
4
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10.7TNFRSF4, AKT1, AKT3, AKT2
5
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10.7AKT3, AKT1, AKT2, DPYSL5
6
Development A2B receptor- action via G-protein alpha s
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10.6AKT2, AKT3, AKT1
710.6AKT2, AKT3, AKT1
810.6AKT1, AKT3, AKT2
9
Apoptosis and survival Caspase cascade
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10.6AKT1, AKT3, AKT2
1010.6AKT1, AKT2, AKT3
1110.6AKT2, AKT3, AKT1
12
Hide members
10.6AKT1, AKT3, AKT2
13
Immune response IL-2 activation and signaling pathway
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10.6AKT1, AKT2, AKT3
14
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10.6AKT2, AKT1, AKT3
1510.6AKT2, AKT3, AKT1
16
Transcription Androgen Receptor nuclear signaling
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10.6AKT1, AKT2, AKT3
17
Immune response ICOS pathway in T-helper cell
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10.6AKT2, AKT3, AKT1
18
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10.6AKT3, AKT2, AKT1
19
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10.6AKT1, AKT2, AKT3
20
Hide members
10.6AKT3, AKT2, AKT1
2110.6AKT3, AKT2, AKT1
2210.6AKT3, AKT2, AKT1
2310.6AKT1, AKT3, AKT2
24
Hide members
10.6AKT2, AKT1, AKT3
25
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10.6AKT2, AKT3, AKT1
2610.6AKT1, AKT3, AKT2
27
Immune response IFN gamma signaling pathway
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10.6AKT2, AKT1, AKT3
28
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
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10.6AKT3, AKT1, AKT2
29
Hide members
10.6AKT1, AKT3, AKT2
3010.6AKT3, AKT2, AKT1
31
Hide members
10.6AKT2, AKT1, AKT3
32
Hide members
10.6AKT1, AKT3, AKT2
33
G-protein signaling Cross-talk between Ras-family GTPases
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10.6AKT1, AKT3, AKT2
34
Hide members
10.6AKT2, AKT3, AKT1
3510.6AKT1, AKT3, AKT2
3610.6AKT2, AKT3, AKT1
3710.6AKT2, AKT3, AKT1
3810.6AKT2, AKT1, AKT3
3910.6AKT1, AKT3, AKT2
4010.6AKT1, AKT3, AKT2
41
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10.6AKT1, AKT3, AKT2
4210.6AKT3, AKT1, AKT2
43
Hide members
10.6AKT1, AKT2, AKT3
4410.6AKT1, AKT2, AKT3
45
Hide members
10.6AKT2, AKT1, AKT3
4610.6AKT1, AKT2, AKT3
4710.6AKT3, AKT2, AKT1
48
Apoptosis and survival Lymphotoxin-beta receptor signaling
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10.6AKT1, AKT3, AKT2
49
Development Leptin signaling via PI3K-dependent pathway
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10.6AKT1, AKT3, AKT2
5010.6DNTT, CD5, CD2

Compounds for genes affiliated with Thymoma

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Sources:
44Novoseek, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank
See all sources

Compounds related to Thymoma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.2IFI27, AKT1, AKT2, NKX2-1, SSTR2, AIRE
2lipid4411.1IFI27, AKT1, AKT3, AKT2, CD2, CD69
3paraffin4411.0IFI27, AKT1, NKX2-1, SSTR2, DNTT, CD5
4sc 795911.0AKT2, AKT3, AKT1
5ly2940024410.9IFI27, AKT1, AKT3, AKT2, CD69
6fpa 1245910.9AKT1, AKT3, AKT2
710-debc hydrochloride5910.9AKT1, AKT3, AKT2
8serine4410.9AKT3, AKT2, NKX2-1, CD69, RYR1
9api-15910.9AKT1, AKT3, AKT2
10api-25910.9AKT2, AKT3, AKT1
11thymidine44 2411.9IFI27, SSTR2, DNTT, CD2, CD69
12gnrh4410.9AKT1, NKX2-1, SSTR2, CD69
13tamoxifen44 49 28 1113.7AKT1, AKT2, SSTR2
14mevastatin44 28 1112.6AKT1, IFI27
15dexamethasone44 49 28 1113.6NKX2-1, AKT1, IFI27
16rapamycin4410.6RYR1, AKT2, AKT1, IFI27
17sodium iodide4410.6NKX2-1, SSTR2
18bzatp44 2811.3DNTT, RYR1

GO Terms for genes affiliated with Thymoma

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16Gene Ontology
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Cellular components related to Thymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.0THY1, RYR1, CD2, CD5, AIRE, SSTR2
2external side of plasma membraneGO:00989710.6TNFRSF4, CD5, CD2, CD69, THY1
3integral to plasma membraneGO:00588710.6CD69, CD2, CD5, SSTR2, TNFRSF4, RYR1

Biological processes related to Thymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of plasma membrane long-chain fatty acid transportGO:01074810.7AKT2, AKT1
2positive regulation of glucose metabolic processGO:01090710.6AKT2, AKT1
3peripheral nervous system myelin maintenanceGO:03228710.6AKT2, AKT1
4glycogen biosynthetic processGO:00597810.6AKT2, AKT1
5mammary gland epithelial cell differentiationGO:06064410.5AKT1, AKT2
6positive regulation of glycogen biosynthetic processGO:04572510.3AKT2, AKT1

Products for genes affiliated with Thymoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thymoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet