MCID: THY023
MIFTS: 63

Thymoma malady

Cancer category

Summaries for Thymoma

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Thymoma is a tumor originating from the epithelial cells of the thymus. Thymoma is an uncommon tumor,... more...

MalaCards: Thymoma, also known as primary thymic epithelial neoplasm, is related to thymic carcinoma and epithelial malignant thymoma, and has symptoms including diplopia/double vision, ptosis and feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia. An important gene associated with Thymoma is AKT2 (v-akt murine thymoma viral oncogene homolog 2), and among its related pathways are PAK Pathway and G-protein signaling G-Protein alpha-i signaling cascades. The compounds tyrosine and lipid have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are cellular and normal.

Description from OMIM:47 274230

Aliases & Classifications for Thymoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Characteristics (Orphanet epidemiological data):

49
thymoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

thymoma 8 10 45 49 47 61
primary thymic epithelial neoplasm 49
primary thymic epithelial tumor 49
thymoma nos 8


External Ids:

Disease Ontology8 DOID:3275
MeSH35 D013945
NCIt40 C3411
SNOMED-CT via Orphanet58 128856005, 444231005
UMLS via Orphanet62 C0040100
OMIM47 274230
MESH via Orphanet36 D013945
ICD10 via Orphanet26 C37, D15.0

Related Diseases for Thymoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Thymoma family:

malignant type a thymoma malignant type ab thymoma
type c thymoma thymoma type a
thymoma type b thymoma type ab

Diseases related to Thymoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1thymic carcinoma31.1CD5, NKX2-1
2epithelial malignant thymoma30.3SLC4A3, HAVCR2
3tuberculosis29.9CD69
4papillary carcinoma29.9NKX2-1, IFI27, SSTR2
5graves' disease29.7TNFRSF4, NKX2-1, AIRE, CD69
6adenocarcinoma29.7IFI27, AKT2, NKX2-1, SSTR2, AKT1
7type c thymoma10.6
8good syndrome10.5
9pemphigus10.5
10thymoma type a10.4
11spindle cell thymoma10.4
12combined thymoma10.4
13cortical thymoma10.4
14limbic encephalitis10.3
15invasive malignant thymoma10.3
16lichen planus10.3
17giant cell myocarditis10.3
18chronic mucocutaneous candidiasis10.3
19stiff-person syndrome10.3
20thymic hyperplasia10.3
21superior vena cava syndrome10.3
22thymic epithelial neoplasm10.3
23paraneoplastic pemphigus10.3
24spindle cell carcinoma10.3
25encapsulated thymoma10.2
26lymphoblastic lymphoma10.2
27t-cell leukemia10.2
28thymic epithelial tumor10.2
29oral lichen planus10.2
30polymyositis10.2
31pemphigus erythematosus10.2
32systemic lupus erythematosus10.2
33n syndrome10.2
34paraneoplastic syndromes10.2
35thymoma type b10.2
36graft versus host disease10.1
37noninvasive malignant thymoma10.1
38pancytopenia10.1
39malignant type a thymoma10.1
40malignant type ab thymoma10.1
41predominantly cortical thymoma10.1
42adenoma10.1
43aplastic anemia10.1
44exfoliative dermatitis10.1
45pemphigus foliaceus10.1
46thymoma type ab10.1
47oral erosive lichen10.1
48refractory anemia10.1
49aregenerative anemia10.1
50cardiac tamponade10.1

Graphical network of the top 20 diseases related to Thymoma:



Diseases related to thymoma

Clinical Features for Thymoma

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

274230

Clinical synopsis from OMIM:

274230

Symptoms:

49 (show all 35)
  • diplopia/double vision
  • ptosis
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • asthenia/fatigue/weakness
  • cutaneous rash
  • mouth dryness/xerostomia
  • thoracic/chest pain
  • cough
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • myositis
  • myocardium anomalies/myocarditis
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • hemolytic anemia
  • agammaglobulinemia/hypogammaglobulinemia/b-cell deficiency
  • nephrotic syndrome
  • thyroiditis
  • thymic aplasia/hypoplasia
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • bone/osseous neoplasm/tumor/carcinoma/cancer
  • lymphadenopathy/polyadenopathies
  • cushingoid morphotype
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • thymus/thymic neoplasm/tumor/carcinoma/cancer/thymoma
  • myasthenia
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • alopecia
  • peritoneal diseases
  • bone marrow failure/pancytopenia
  • xerophthalmia/dry eyes
  • mediastinal anomalies
  • lymphocytes anomalies

Drugs & Therapeutics for Thymoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Thymoma

Drug clinical trials:

Search ClinicalTrials for Thymoma

Search NIH Clinical Center for Thymoma

Search CenterWatch for Thymoma

Genetic Tests for Thymoma

Anatomical Context for Thymoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Thymoma:

33
Skin, Liver, Brain, Lymph node, Lung, Bone marrow, Whole blood, Thymus, Heart, Small intestine, Colon, Thyroid, Breast, Placenta, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Pituitary

Animal Models for Thymoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Thymoma

Sources:
51PubMed
See all sources

Articles related to Thymoma:

(show top 50)    (show all 878)
idTitleAuthorsYear
1
Is thymectomy necessary in nonmyasthenic patients with early thymoma? (23594467)
2013
2
Ectopic Cervical Thymoma Accompanied by Good's Syndrome. (23364225)
2013
3
Ectopic hamartomatous thymoma: radiographic and clinicopathological features. (23422210)
2013
4
Effect of chemotherapy on autoimmune hepatitis in thymoma: a case report and literature review. (24379993)
2013
5
V-AKT murine thymoma viral oncogene homolog/mammalian target of rapamycin activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis. (22271091)
2012
6
Pathological comparative assessment of two cases of thymic cyst and cystic thymoma and review of the literature. (23272534)
2012
7
Spontaneous thymoma in a 10-week-old sprague-dawley rat. (22481857)
2012
8
Thymectomy for thymoma and myasthenia gravis. A survey of current surgical practice in thymic disease amongst EACTS members. (22374292)
2012
9
Acute presentation of autoimmune hepatitis in a patient with myasthenia gravis, thymoma, Hashimoto thyroiditis and connective tissue disorder. (22776553)
2012
10
High prevalence of infections and autoimmunity in patients with thymoma. (22261388)
2012
11
Anterior mediastinal paraganglioma mimicking thymoma. (22698609)
2012
12
Invasive thymoma in a child: a rare case report. (22325416)
2012
13
Totally cervical thymoma from the orthotopic thymus. (21766278)
2012
14
eComment: Video-assisted thymectomy for thymoma. (21257951)
2011
15
Malignant thymoma as etiology of bilateral, biventricular cardiac failure. (21954545)
2011
16
Comparison of surgical techniques for early-stage thymoma: feasibility of minimally invasive thymectomy and comparison with open resection. (21255798)
2011
17
The need for organization and collaboration: establishing a thymoma registry. (21070995)
2011
18
Platelet-derived growth factor and platelet-derived growth factor receptor-I+ expression in the normal human thymus and thymoma. (21645144)
2011
19
Atypical thymoma (World Health Organization Type B3) with neuroendocrine differentiation combined with hyperparathyroidism. (20736809)
2010
20
Malignant thymoma with immunodeficiency (Good syndrome) associated with mucormycosis. (20139744)
2010
21
Chronic cough in thymoma. (21485607)
2010
22
Giant cystic thymoma with haemorrhage and necrosis: an unusual case. (19445448)
2009
23
An unusual case of malignant thymoma associated graft-versus-host disease. (21853007)
2009
24
Autoimmune haemolytic anaemia associated with a thymoma: case report and review of the literature. (19999396)
2009
25
The value of transcapsular invasion in patients with thymoma. (19722737)
2009
26
Resolution of CD8+ lymphomatoid papulosis after surgical excision of the type AB-thymoma. (19542925)
2009
27
Pseudoischemic electrocardiogram in myasthenia gravis with thymoma: reversibility after thymectomy. (19330853)
2009
28
Thymoma: a focus on current therapeutic management. (19096319)
2009
29
Pure red cell aplasia associated with thymoma: Is thymectomy the cure? (18499248)
2009
30
Myasthenia gravis and autoimmune Addison disease in a patient with thymoma. (19808197)
2009
31
DNA ploidy in thymoma and associated multiple primary malignancies in the same patient. (19175064)
2008
32
Ectopic thymoma with pure red cell aplasia--ambiguity with indolence. (19059124)
2008
33
Familial occurrence of thymoma and autoimmune diseases with the constitutional translocation t(14;20)(q24.1;p12.3). (15942943)
2005
34
Thymoma-associated neuromyotonia with antibodies against voltage-gated potassium channels presenting as chronic intestinal pseudo-obstruction. (15753614)
2005
35
Thymoma-associated exfoliative dermatitis in cats. (15232147)
2004
36
The significance of titin antibodies in myasthenia gravis--correlation with thymoma and severity of myasthenia gravis. (15316806)
2004
37
Aplastic pancytopenia associated with thymoma. (11131928)
2000
38
Myasthenia gravis, thymoma, intestinal pseudo-obstruction, and neuronal nicotinic acetylcholine receptor antibody. (10514242)
1999
39
Pemphigus erythematosus associated with thymoma: a case report. (10500920)
1999
40
A giant invasive thymoma made resectable by cisplatin + vincristine + doxorubicin + etoposide (CODE)]. (10234303)
1999
41
Titin transcripts in thymomas. (9668270)
1998
42
Immunohistochemical staining for bcl-2 and mcl-1 in intrathyroidal epithelial thymoma (ITET)/carcinoma showing thymus-like differentiation (CASTLE) and cervical thymic carcinoma. (9796728)
1998
43
Intensive chemotherapy with cisplatin, doxorubicin, cyclophosphamide, etoposide and granulocyte colony-stimulating factor for advanced thymoma or thymic cancer: preliminary results. (7474409)
1995
44
Thymoma, myasthenia gravis, and relapsing polychondritis. (3382108)
1988
45
Intractable ventricular tachycardia in a patient with giant cell myocarditis, thymoma and myasthenia gravis. (3793292)
1986
46
A spindle cell varient of thymic carcinoid tumor. A clinical, histologic, and fine structural study with emphasis on its distinction from spindle cell thymoma. (946757)
1976
47
Chronic mucocutaneous candidiasis, myositis, and thymoma. A new triad. (4564702)
1972
48
Chronic mucocutaneous candidiasis of the adult. A report of a patient with an associated thymoma. (5009626)
1972
49
THE SYNDROME OF BENIGN THYMOMA AND PRIMARY AREGENERATIVE ANEMIA; AN ANALYSIS OF FORTY-THREE CASES. (14169820)
1964
50
The simultaneous occurrence of benign thymoma and refractory anemia. (13208746)
1954

Genetic Variations for Thymoma

Expression for genes affiliated with Thymoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Thymoma

Search GEO for disease gene expression data for Thymoma.

Pathways for genes affiliated with Thymoma

Sources:
52QIAGEN, 12EMD Millipore, 56SinoBiological, 53R&D Systems, 54Reactome, 30KEGG, 60Tocris Bioscience, 38NCBI BioSystems Database, 4Cell Signaling Technology, 50PharmGKB
See all sources

Pathways related to Thymoma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7TNFRSF4, CD2, AKT3, AKT1, AKT2
2
G-protein signaling G-Protein alpha-i signaling cascades
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10.7RYR1, AKT2, AKT1, AKT3
3
Cell adhesion Integrin-mediated cell adhesion and migration
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10.7NKX2-1, AKT1, AKT2, AKT3
4
Hide members
10.7TNFRSF4, AKT1, AKT3, AKT2
5
Hide members
10.7AKT2, AKT1, AKT3, DPYSL5
6
Development A2B receptor- action via G-protein alpha s
Hide members
10.6AKT1, AKT3, AKT2
710.6AKT2, AKT1, AKT3
810.6AKT1, AKT2, AKT3
9
Hide members
10.6AKT1, AKT2, AKT3
1010.6AKT1, AKT3, AKT2
1110.6AKT1, AKT2, AKT3
12
Hide members
10.6AKT2, AKT1, AKT3
13
Immune response IL-2 activation and signaling pathway
Hide members
10.6AKT1, AKT2, AKT3
14
Apoptosis and survival Caspase cascade
Hide members
10.6AKT3, AKT1, AKT2
1510.6AKT2, AKT1, AKT3
16
Hide members
10.6AKT3, AKT2, AKT1
17
Immune response ICOS pathway in T-helper cell
Hide members
10.6AKT1, AKT2, AKT3
18
Hide members
10.6AKT2, AKT3, AKT1
19
Hide members
10.6AKT1, AKT3, AKT2
20
Transcription Androgen Receptor nuclear signaling
Hide members
10.6AKT1, AKT3, AKT2
2110.6AKT3, AKT1, AKT2
2210.6AKT3, AKT2, AKT1
2310.6AKT3, AKT1, AKT2
24
Hide members
10.6AKT3, AKT1, AKT2
25
Hide members
10.6AKT1, AKT3, AKT2
2610.6AKT1, AKT3, AKT2
27
Immune response IFN gamma signaling pathway
Hide members
10.6AKT2, AKT1, AKT3
28
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
Hide members
10.6AKT3, AKT1, AKT2
29
Hide members
10.6AKT1, AKT3, AKT2
3010.6AKT3, AKT2, AKT1
31
Hide members
10.6AKT2, AKT1, AKT3
32
Hide members
10.6AKT1, AKT3, AKT2
33
G-protein signaling Cross-talk between Ras-family GTPases
Hide members
10.6AKT1, AKT3, AKT2
34
Hide members
10.6AKT2, AKT3, AKT1
3510.6AKT1, AKT3, AKT2
3610.6AKT2, AKT3, AKT1
3710.6AKT2, AKT3, AKT1
3810.6AKT2, AKT1, AKT3
3910.6AKT1, AKT3, AKT2
4010.6AKT1, AKT3, AKT2
41
Hide members
10.6AKT1, AKT3, AKT2
4210.6AKT3, AKT1, AKT2
43
Hide members
10.6AKT1, AKT2, AKT3
4410.6AKT1, AKT2, AKT3
45
Hide members
10.6AKT2, AKT1, AKT3
4610.6AKT1, AKT2, AKT3
4710.6AKT3, AKT2, AKT1
48
Apoptosis and survival Lymphotoxin-beta receptor signaling
Hide members
10.6AKT1, AKT3, AKT2
49
Development Leptin signaling via PI3K-dependent pathway
Hide members
10.6AKT1, AKT3, AKT2
5010.6CD5, CD2, DNTT

Compounds for genes affiliated with Thymoma

Sources:
45Novoseek, 60Tocris Bioscience, 24HMDB, 50PharmGKB, 29IUPHAR, 11DrugBank
See all sources

Compounds related to Thymoma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.2IFI27, AKT1, AKT2, NKX2-1, SSTR2, AIRE
2lipid4511.1IFI27, AKT1, AKT3, AKT2, CD2, CD69
3paraffin4511.0IFI27, AKT1, NKX2-1, SSTR2, DNTT, CD5
4sc 796011.0AKT2, AKT3, AKT1
5ly2940024510.9IFI27, AKT1, AKT3, AKT2, CD69
6fpa 1246010.9AKT1, AKT3, AKT2
710-debc hydrochloride6010.9AKT1, AKT3, AKT2
8serine4510.9AKT3, AKT2, NKX2-1, CD69, RYR1
9api-16010.9AKT1, AKT3, AKT2
10api-26010.9AKT2, AKT3, AKT1
11thymidine45 2411.9IFI27, SSTR2, DNTT, CD2, CD69
12gnrh4510.9AKT1, NKX2-1, SSTR2, CD69
13tamoxifen45 50 29 1113.7AKT1, AKT2, SSTR2
14mevastatin45 29 1112.6AKT1, IFI27
15dexamethasone45 50 29 1113.6NKX2-1, AKT1, IFI27
16rapamycin4510.6RYR1, AKT2, AKT1, IFI27
17sodium iodide4510.6NKX2-1, SSTR2
18bzatp45 2911.3DNTT, RYR1

GO Terms for genes affiliated with Thymoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Thymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.0AKT3, AKT2, SSTR2, AIRE, CD5, CD2
2external side of plasma membraneGO:00989710.6THY1, CD69, CD2, CD5, TNFRSF4
3integral to plasma membraneGO:00588710.6TNFRSF4, SSTR2, CD5, CD2, CD69, RYR1

Biological processes related to Thymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of plasma membrane long-chain fatty acid transportGO:01074810.7AKT2, AKT1
2positive regulation of glucose metabolic processGO:01090710.6AKT2, AKT1
3peripheral nervous system myelin maintenanceGO:03228710.6AKT2, AKT1
4glycogen biosynthetic processGO:00597810.6AKT2, AKT1
5mammary gland epithelial cell differentiationGO:06064410.5AKT1, AKT2
6positive regulation of glycogen biosynthetic processGO:04572510.3AKT2, AKT1

Products for genes affiliated with Thymoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thymoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet