MCID: THY023
MIFTS: 66

Thymoma malady

Cancer diseases category

Summaries for Thymoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Thymoma is a tumor originating from the epithelial cells of the thymus. Thymoma is an uncommon tumor,... more...

MalaCards: Thymoma, also known as primary thymic epithelial neoplasm, is related to myasthenia gravis and leukemia, and has symptoms including hemolytic anemia, hepatic/liver neoplasm/tumor/carcinoma/cancer and lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer. An important gene associated with Thymoma is AKT2 (v-akt murine thymoma viral oncogene homolog 2), and among its related pathways are PAK Pathway and G-protein signaling G-Protein alpha-i signaling cascades. The compounds tyrosine and lipid have been mentioned in the context of this disorder. Affiliated tissues include thymus, t cells and lung, and related mouse phenotypes are cellular and normal.

Description from OMIM:46 274230

Aliases & Classifications for Thymoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
thymoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

thymoma 8 10 44 48 46 60
primary thymic epithelial neoplasm 48
primary thymic epithelial tumor 48
thymoma nos 8


External Ids:

Disease Ontology8 DOID:3275
MeSH34 D013945
NCIt39 C3411
SNOMED-CT via Orphanet57 128856005, 444231005
UMLS via Orphanet61 C0040100
OMIM46 274230
MESH via Orphanet35 D013945
ICD10 via Orphanet26 C37, D15.0

Related Diseases for Thymoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Thymoma family:

Malignant Type a Thymoma Malignant Type Ab Thymoma
Type C Thymoma Thymoma Type a
Thymoma Type B Thymoma Type Ab

Diseases related to Thymoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1myasthenia gravis31.3TNFRSF4, AIRE, RYR1
2leukemia30.4IFI27, TNFRSF4, AKT1, DNTT, CD5, CD2
3epithelial malignant thymoma30.3SLC4A3, HAVCR2
4lung cancer30.1IFI27, AKT2, NKX2-1, DPYSL5
5sarcoma30.0SSTR2, THY1, EVPL
6hepatitis30.0AIRE
7melanoma29.9IFI27, TNFRSF4, AKT1, AKT3, NKX2-1, SSTR2
8thymus cancer29.9CD5, NKX2-1
9tuberculosis29.9CD69
10papillary carcinoma29.9IFI27, NKX2-1, SSTR2
11graves' disease29.7TNFRSF4, NKX2-1, AIRE, CD69
12adenocarcinoma29.7IFI27, AKT1, AKT2, NKX2-1, SSTR2
13hodgkin's lymphoma29.7MSC
14neuroendocrine tumor29.7SSTR2, NKX2-1, IFI27
15breast cancer29.7IFI27, AKT1, AKT2, NKX2-1, SSTR2
16thymic carcinoma10.7
17pure red-cell aplasia10.6
18pemphigus10.5
19cervicitis10.4
20encephalitis10.4
21mediastinitis10.4
22good syndrome10.4
23spindle cell thymoma10.4
24combined thymoma10.4
25cortical thymoma10.3
26myocarditis10.3
27candidiasis10.3
28invasive malignant thymoma10.3
29thyroiditis10.3
30lichen planus10.3
31chronic mucocutaneous candidiasis10.2
32stiff-person syndrome10.2
33spindle cell carcinoma10.2
34encapsulated thymoma10.2
35intestinal obstruction10.2
36intestinal pseudo-obstruction10.2
37lupus erythematosus10.2
38myositis10.2
39systemic lupus erythematosus10.1
40dendritic cell thymoma10.1
41dermatitis10.1
42lymphoblastic leukemia10.1
43mixed type thymoma10.1
44type c thymoma10.1
45graft versus host disease10.1
46noninvasive malignant thymoma10.1
47pancytopenia10.1
48malignant type a thymoma10.1
49malignant type ab thymoma10.1
50predominantly cortical thymoma10.1

Graphical network of the top 20 diseases related to Thymoma:



Diseases related to thymoma

Clinical Features for Thymoma

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

274230

Clinical synopsis from OMIM:

274230

Symptoms:

48 (show all 35)
  • hemolytic anemia
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • bone/osseous neoplasm/tumor/carcinoma/cancer
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • cushingoid morphotype
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • bone marrow failure/pancytopenia
  • agammaglobulinemia/hypogammaglobulinemia/b-cell deficiency
  • restricted joint mobility/joint stiffness/ankylosis
  • asthenia/fatigue/weakness
  • myasthenia
  • lymphadenopathy/polyadenopathies
  • cough
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • thoracic/chest pain
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • ptosis
  • diplopia/double vision
  • thymus/thymic neoplasm/tumor/carcinoma/cancer/thymoma
  • lymphocytes anomalies
  • xerophthalmia/dry eyes
  • mouth dryness/xerostomia
  • arthritis/synovitis/synovial proliferation
  • myositis
  • thyroiditis
  • nephrotic syndrome
  • thymic aplasia/hypoplasia
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • myocardium anomalies/myocarditis
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • peritoneal diseases
  • alopecia
  • cutaneous rash
  • mediastinal anomalies

Drugs & Therapeutics for Thymoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Thymoma

Drug clinical trials:

Search ClinicalTrials for Thymoma

Search NIH Clinical Center for Thymoma

Search CenterWatch for Thymoma

Genetic Tests for Thymoma

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Anatomical Context for Thymoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Thymoma:

32
Thymus, T cells, Lung, Thyroid, Bone, B cells, Liver, Bone marrow, Eye, Brain, Breast, Skin, Lymph node, Pituitary, Colon, Heart, Placenta, Testes, Endothelial

Animal Models for Thymoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Thymoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.2AKT2, AKT3, AKT1, HAVCR2, TNFRSF4, NKX2-1
2MP:000287311.1MSC, TNFRSF4, AKT1, AKT3, AKT2, AIRE
3MP:000538810.9TNFRSF4, AKT1, AKT2, NKX2-1, AIRE, RYR1
4MP:000539710.9TNFRSF4, HAVCR2, AKT1, AKT3, AKT2, AIRE
5MP:000538710.8TNFRSF4, HAVCR2, AKT1, AKT3, AKT2, AIRE
6MP:000538110.8MSC, RYR1, AIRE, SSTR2, NKX2-1, TNFRSF4
7MP:000363110.4NKX2-1, SSTR2, AIRE, DPYSL5, SLC4A3

Publications for Thymoma

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Sources:
50PubMed
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Articles related to Thymoma:

(show top 50)    (show all 869)
idTitleAuthorsYear
1
Intracaval and intracardiac extension of invasive thymoma complicated by superior and inferior vena cava syndrome. (23356226)
2013
2
Myocarditis after thymoma resection, with left ventricular hypokinesia mimicking acute coronary syndrome. (23483300)
2013
3
Current readings: The most influential and recent studies involving surgical management of thymoma. (24216530)
2013
4
Chemotherapy for thymic carcinoma and advanced thymoma in adults. (23970462)
2013
5
Myasthenia gravis associated with thymoma and toxic multinodular goiter. A case report. (23077950)
2012
6
Unusual clinical behaviour of thymoma with recurrent myasthenia gravis. (22378319)
2012
7
Follicular thyroid carcinoma in a patient with myasthenia gravis and thymoma: a rare association. (23074376)
2012
8
Thymomaptysis: unusual presentation of invasive thymoma. (22290246)
2012
9
Phosphoproteomic analysis of mouse thymoma cells treated with tributyltin oxide: TBTO affects proliferation and energy sensing pathways. (22174045)
2012
10
Thymoma: current concepts. (23176011)
2012
11
Which stages of thymoma benefit from adjuvant chemotherapy post-thymectomy? (22552797)
2012
12
Association of clinical and pathological variables with survival in thymoma. (22057358)
2012
13
First description of the role of A^a8,F-FDG-PET/CT as compared to CT, MRI to suspect a case of thymoma in a pediatric patient. (22413119)
2012
14
Thymoma and autoimmunity. (21317916)
2011
15
Type AB thymoma with brain metastasis: Report of a case. (21922373)
2011
16
SOX2 gene expression in normal human thymus and thymoma. (21190055)
2011
17
Ectopic thymoma presenting as a giant intrathoracic tumor: a case report. (21711524)
2011
18
Thymoma-associated paraneoplastic encephalitis (TAPE): diagnosis and treatment of a potentially fatal condition. (21167513)
2011
19
Thymoma-associated myasthenia gravis without acetylcholine receptor antibodies. (21236448)
2011
20
Recurrence of thymoma. (21459604)
2011
21
Thymoma associated with malignancies may herald a hereditary cancer syndrome. (20734236)
2010
22
Thymoma and paraneoplastic myasthenia gravis. (20380583)
2010
23
A comparative study of the spatial distribution of mast cells and microvessels in the foetal, adult human thymus and thymoma. (20002837)
2010
24
Diagnostic and clinical significance of D2-40 expression in the normal human thymus and thymoma. (20495736)
2010
25
The multidisciplinary approach to thymoma: combining molecular and clinical approaches. (20859125)
2010
26
Thymoma in children: report of 2 cases and review of the literature. (20055684)
2010
27
Management of pleural recurrence after curative resection of thymoma. (19379989)
2009
28
Association of HLA-A in autoimmune myasthenia gravis with thymoma. (19278738)
2009
29
Prognostic predictors and long-term outcome of postoperative irradiation in thymoma: a study of 241 patients. (19909016)
2009
30
Invasive thymoma with intraorbital metastases. (19293488)
2009
31
Thymoma with dissemination: efficacy of macroscopic total resection of disseminated nodules. (19424745)
2009
32
Preferential expression of AChR epsilon-subunit in thymomas from patients with myasthenia gravis. (18657869)
2008
33
Evidence-based pathology and the pathologic evaluation of thymomas: the World Health Organization classification can be simplified into only 3 categories other than thymic carcinoma. (18442102)
2008
34
Characteristics of thymoma successfully resected by videothoracoscopic surgery. (17342355)
2007
35
Voltage-gated potassium channel antibodies associated limbic encephalitis in a patient with invasive thymoma. (17028029)
2006
36
Fatal giant cell myocarditis after thymoma resection in myasthenia gravis. (16434294)
2006
37
Thymectomy for paraneoplastic stiff-person syndrome associated with invasive thymoma. (16798340)
2006
38
Von hippel-lindau disease associated with thymoma and myasthenia gravis. (19078784)
2005
39
Expression of calretinin and other mesothelioma-related markers in thymic carcinoma and thymoma. (14652817)
2003
40
Epidermal growth factor receptor expression in invasive thymoma. (11935304)
2002
41
Titin and ryanodine receptor autoantibodies in dogs with thymoma and late-onset myasthenia gravis. (11182151)
2001
42
Effects of satratoxins and other macrocyclic trichothecenes on IL-2 production and viability of EL-4 thymoma cells. (10494915)
1999
43
Thymoma-associated pancytopenia: effectiveness of cyclosporine A. (9829850)
1998
44
A case of giant cell myocarditis and malignant thymoma: a postmortem diagnosis by needle biopsy. (9474466)
1998
45
Pure red cell aplasia and myasthenia gravis with thymoma: a case report and review of the literature. (9861237)
1998
46
Malignant thymoma in a patient with HIV positivity: a case report with a review of the differential cytologic diagnoses. (9099551)
1997
47
Thymic carcinosarcoma associated with a spindle cell thymoma: an immunohistochemical study. (1398523)
1992
48
Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma. (1463094)
1992
49
Thymoma with pure red cell aplasia and hemophagocytic syndrome--one case report]. (1848151)
1991
50
Intractable ventricular tachycardia in a patient with giant cell myocarditis, thymoma and myasthenia gravis. (3793292)
1986

Genetic Variations for Thymoma

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Expression for genes affiliated with Thymoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thymoma

Search GEO for disease gene expression data for Thymoma.

Pathways for genes affiliated with Thymoma

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Sources:
51QIAGEN, 12EMD Millipore, 55SinoBiological, 52R&D Systems, 53Reactome, 29KEGG, 59Tocris Bioscience, 37NCBI BioSystems Database, 4Cell Signaling Technology, 49PharmGKB
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Pathways related to Thymoma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7TNFRSF4, CD2, AKT3, AKT1, AKT2
2
G-protein signaling G-Protein alpha-i signaling cascades
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10.7RYR1, AKT2, AKT1, AKT3
3
Cell adhesion Integrin-mediated cell adhesion and migration
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10.7NKX2-1, AKT1, AKT2, AKT3
4
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10.7TNFRSF4, AKT1, AKT3, AKT2
5
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10.7AKT2, AKT1, AKT3, DPYSL5
6
Development A2B receptor- action via G-protein alpha s
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10.6AKT1, AKT3, AKT2
710.6AKT2, AKT1, AKT3
810.6AKT1, AKT2, AKT3
9
Hide members
10.6AKT1, AKT2, AKT3
1010.6AKT1, AKT3, AKT2
1110.6AKT1, AKT2, AKT3
12
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10.6AKT2, AKT1, AKT3
13
Immune response IL-2 activation and signaling pathway
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10.6AKT1, AKT2, AKT3
14
Apoptosis and survival Caspase cascade
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10.6AKT3, AKT1, AKT2
1510.6AKT2, AKT1, AKT3
16
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10.6AKT3, AKT2, AKT1
17
Immune response ICOS pathway in T-helper cell
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10.6AKT1, AKT2, AKT3
18
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10.6AKT2, AKT3, AKT1
19
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10.6AKT1, AKT3, AKT2
20
Transcription Androgen Receptor nuclear signaling
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10.6AKT1, AKT3, AKT2
2110.6AKT3, AKT1, AKT2
2210.6AKT3, AKT2, AKT1
2310.6AKT3, AKT1, AKT2
24
Hide members
10.6AKT3, AKT1, AKT2
25
Hide members
10.6AKT1, AKT3, AKT2
2610.6AKT1, AKT3, AKT2
27
Immune response IFN gamma signaling pathway
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10.6AKT2, AKT1, AKT3
28
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
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10.6AKT3, AKT1, AKT2
29
Hide members
10.6AKT1, AKT3, AKT2
3010.6AKT3, AKT2, AKT1
31
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10.6AKT2, AKT1, AKT3
32
Hide members
10.6AKT1, AKT3, AKT2
33
G-protein signaling Cross-talk between Ras-family GTPases
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10.6AKT1, AKT3, AKT2
34
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10.6AKT2, AKT3, AKT1
3510.6AKT1, AKT3, AKT2
3610.6AKT2, AKT3, AKT1
3710.6AKT2, AKT3, AKT1
3810.6AKT2, AKT1, AKT3
3910.6AKT1, AKT3, AKT2
4010.6AKT1, AKT3, AKT2
41
Hide members
10.6AKT1, AKT3, AKT2
4210.6AKT3, AKT1, AKT2
43
Hide members
10.6AKT1, AKT2, AKT3
4410.6AKT1, AKT2, AKT3
45
Hide members
10.6AKT2, AKT1, AKT3
4610.6AKT1, AKT2, AKT3
4710.6AKT3, AKT2, AKT1
48
Apoptosis and survival Lymphotoxin-beta receptor signaling
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10.6AKT1, AKT3, AKT2
49
Development Leptin signaling via PI3K-dependent pathway
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10.6AKT1, AKT3, AKT2
5010.6CD5, CD2, DNTT

Compounds for genes affiliated with Thymoma

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Sources:
44Novoseek, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank
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Compounds related to Thymoma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.2IFI27, AKT1, AKT2, NKX2-1, SSTR2, AIRE
2lipid4411.1IFI27, AKT1, AKT3, AKT2, CD2, CD69
3paraffin4411.0IFI27, AKT1, NKX2-1, SSTR2, DNTT, CD5
4sc 795911.0AKT2, AKT3, AKT1
5ly2940024410.9IFI27, AKT1, AKT3, AKT2, CD69
6fpa 1245910.9AKT1, AKT3, AKT2
710-debc hydrochloride5910.9AKT1, AKT3, AKT2
8serine4410.9AKT3, AKT2, NKX2-1, CD69, RYR1
9api-15910.9AKT1, AKT3, AKT2
10api-25910.9AKT2, AKT3, AKT1
11thymidine44 2411.9IFI27, SSTR2, DNTT, CD2, CD69
12gnrh4410.9AKT1, NKX2-1, SSTR2, CD69
13tamoxifen44 49 28 1113.7AKT1, AKT2, SSTR2
14mevastatin44 28 1112.6AKT1, IFI27
15dexamethasone44 49 28 1113.6NKX2-1, AKT1, IFI27
16rapamycin4410.6RYR1, AKT2, AKT1, IFI27
17sodium iodide4410.6NKX2-1, SSTR2
18bzatp44 2811.3DNTT, RYR1

GO Terms for genes affiliated with Thymoma

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16Gene Ontology
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Cellular components related to Thymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.0AKT3, AKT2, SSTR2, AIRE, CD5, CD2
2external side of plasma membraneGO:00989710.6THY1, CD69, CD2, CD5, TNFRSF4
3integral to plasma membraneGO:00588710.6TNFRSF4, SSTR2, CD5, CD2, CD69, RYR1

Biological processes related to Thymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of plasma membrane long-chain fatty acid transportGO:01074810.7AKT2, AKT1
2positive regulation of glucose metabolic processGO:01090710.6AKT2, AKT1
3peripheral nervous system myelin maintenanceGO:03228710.6AKT2, AKT1
4glycogen biosynthetic processGO:00597810.6AKT2, AKT1
5mammary gland epithelial cell differentiationGO:06064410.5AKT1, AKT2
6positive regulation of glycogen biosynthetic processGO:04572510.3AKT2, AKT1

Products for genes affiliated with Thymoma

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  • Antibodies
  • Proteins
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Sources for Thymoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet