MCID: THY023
MIFTS: 57

Thymoma malady

Cancer diseases, Rare diseases categories

Aliases & Classifications for Thymoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Thymoma, Aliases & Descriptions:

Name: Thymoma 9 11 43 47 60
Primary Thymic Epithelial Neoplasm 47
 
Primary Thymic Epithelial Tumor 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 47 
Rare tumors


Characteristics (Orphanet epidemiological data):

47
thymoma:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:3275
MeSH33 D013945
NCIt38 C3411
Orphanet47 99867
MESH via Orphanet34 D013945
ICD10 via Orphanet26 C37, D15.0
UMLS via Orphanet61 C0040100

Summaries for Thymoma

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Disease Ontology:9 A thymus cancer that derives from epithelial cells located in the thymus. the tumor cells in a thymoma look similar to the normal cells of the thymus, grow slowly, and rarely spread beyond the thymus.

MalaCards based summary: Thymoma, also known as primary thymic epithelial neoplasm, is related to thymic carcinoma and thyroiditis, and has symptoms including neoplasm of the thymus, mediastinal lymphadenopathy and ptosis. An important gene associated with Thymoma is AKT2 (v-akt murine thymoma viral oncogene homolog 2), and among its related pathways are NGF Pathway and Apoptosis and survival Caspase cascade. The compounds sc 79 and fpa 124 have been mentioned in the context of this disorder. Affiliated tissues include the thymus, thymus and lung, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Wikipedia:63 Thymoma is a tumor originating from the epithelial cells of the thymus. Thymoma is an uncommon tumor,... more...

Related Diseases for Thymoma

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Diseases in the Thymoma family:

Malignant Type a Thymoma Malignant Type Ab Thymoma
Type C Thymoma Thymoma Type a
Thymoma Type B Thymoma Type Ab

Diseases related to Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 221)
idRelated DiseaseScoreTop Affiliating Genes
1thymic carcinoma31.4CD5, NKX2-1
2thyroiditis31.1CTLA4
3myasthenia gravis31.0AIRE, TNFRSF4, CTLA4, RYR1
4autoimmune hepatitis30.3AIRE, CTLA4
5hypothyroidism30.2NKX2-1, AIRE
6leukemia30.1TNFRSF4, AKT1, EVPL, CD2, CD5
7systemic lupus erythematosus30.1CTLA4, CD2, TNFRSF4
8hypoparathyroidism30.1CTLA4, AIRE
9lung cancer29.8CTLA4, NKX2-1, SSTR2, AKT1, AKT2
10rheumatoid arthritis29.6TNFRSF4, AKT1, CD5, CTLA4
11graves' disease29.5AIRE, TNFRSF4, NKX2-1, CTLA4
12melanoma29.0TNFRSF4, AKT3, AKT1, SSTR2, NKX2-1, CD2
13pure red-cell aplasia10.6
14pemphigus10.5
15cervicitis10.5
16encephalitis10.5
17mediastinitis10.5
18good syndrome10.5
19spindle cell thymoma10.5
20palmoplantar keratoderma, nonepidermolytic10.4EVPL
21myocarditis10.4
22limbic encephalitis10.4
23neuroendocrine tumor10.4SSTR2
24cortical thymoma10.3
25invasive malignant thymoma10.3
26candidiasis10.3
27lichen planus10.3
28stiff-person syndrome10.3
29wegener granulomatosis10.3CTLA4
30chronic mucocutaneous candidiasis10.3
31lupus erythematosus10.3
32myositis10.3
33giant cell myocarditis10.3
34thymic hyperplasia10.3
35paraneoplastic pemphigus10.3
36epithelial malignant thymoma10.3
37encapsulated thymoma10.3
38intestinal pseudo-obstruction10.3
39polymyositis10.3
40superior vena cava syndrome10.3
41type c thymoma10.2
42predominantly cortical thymoma10.2
43dermatitis10.2
44mixed type thymoma10.2
45paraneoplastic syndromes10.2
46nodular goiter10.2TNFRSF4, CTLA4
47lymphoblastic lymphoma10.2
48pemphigus foliaceus10.2
49noninvasive malignant thymoma10.2
50malignant type a thymoma10.2

Graphical network of the top 20 diseases related to Thymoma:



Diseases related to thymoma

Symptoms for Thymoma

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Symptoms:

 47 (show all 35)
  • mediastinal anomalies
  • lymphocytes anomalies
  • thymus/thymic neoplasm/tumor/carcinoma/cancer/thymoma
  • diplopia/double vision
  • ptosis
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • thoracic/chest pain
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • lymphadenopathy/polyadenopathies
  • myasthenia
  • asthenia/fatigue/weakness
  • xerophthalmia/dry eyes
  • mouth dryness/xerostomia
  • cutaneous rash
  • alopecia
  • peritoneal diseases
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • myocardium anomalies/myocarditis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • thymic aplasia/hypoplasia
  • nephrotic syndrome
  • thyroiditis
  • myositis
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • agammaglobulinemia/hypogammaglobulinemia/b-cell deficiency
  • bone marrow failure/pancytopenia
  • hemolytic anemia
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • bone/osseous neoplasm/tumor/carcinoma/cancer
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • cushingoid morphotype

HPO human phenotypes related to Thymoma:

(show all 30)
id Description Frequency HPO Source Accession
1 neoplasm of the thymus hallmark (90%) HP:0100521
2 mediastinal lymphadenopathy hallmark (90%) HP:0100721
3 ptosis typical (50%) HP:0000508
4 diplopia typical (50%) HP:0000651
5 respiratory insufficiency typical (50%) HP:0002093
6 fatigable weakness typical (50%) HP:0003473
7 feeding difficulties in infancy typical (50%) HP:0008872
8 chest pain typical (50%) HP:0100749
9 nephrotic syndrome occasional (7.5%) HP:0000100
10 xerostomia occasional (7.5%) HP:0000217
11 skin rash occasional (7.5%) HP:0000988
12 keratoconjunctivitis sicca occasional (7.5%) HP:0001097
13 arthritis occasional (7.5%) HP:0001369
14 limitation of joint mobility occasional (7.5%) HP:0001376
15 hypercortisolism occasional (7.5%) HP:0001578
16 alopecia occasional (7.5%) HP:0001596
17 abnormality of the myocardium occasional (7.5%) HP:0001637
18 abnormality of the pericardium occasional (7.5%) HP:0001697
19 hemolytic anemia occasional (7.5%) HP:0001878
20 abnormality of the pleura occasional (7.5%) HP:0002103
21 abnormality of the peritoneum occasional (7.5%) HP:0002585
22 neoplasm of the liver occasional (7.5%) HP:0002896
23 hypogammaglobulinemia occasional (7.5%) HP:0004313
24 neoplasm of the nervous system occasional (7.5%) HP:0004375
25 bone marrow hypocellularity occasional (7.5%) HP:0005528
26 aplasia/hypoplasia of the thymus occasional (7.5%) HP:0010515
27 neoplasm of the skeletal system occasional (7.5%) HP:0010622
28 neoplasm of the lung occasional (7.5%) HP:0100526
29 myositis occasional (7.5%) HP:0100614
30 thyroiditis occasional (7.5%) HP:0100646

Drugs & Therapeutics for Thymoma

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Drug clinical trials:

Search ClinicalTrials for Thymoma

Search NIH Clinical Center for Thymoma

Genetic Tests for Thymoma

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Anatomical Context for Thymoma

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MalaCards organs/tissues related to Thymoma:

31
Thymus, Lung, T cells, Bone, Thyroid, Bone marrow, Liver, B cells, Skin, Eye, Brain, Lymph node, Breast, Heart, Colon, Placenta, Testes, Endothelial, Pituitary, Neutrophil

FMA organs/tissues related to Thymoma:

14
The thymus

Animal Models for Thymoma or affiliated genes

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Publications for Thymoma

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Articles related to Thymoma:

(show top 50)    (show all 920)
idTitleAuthorsYear
1
Thymoma of the left thymic lobe with a contralateral small pleural implant successfully detected with diffusion-weighted MRI. (25702681)
2015
2
Immunohistochemical status of PD-L1 in thymoma and thymic carcinoma. (25799277)
2015
3
A case of good syndrome presumed secondary to metastatic pancreatic thymoma in a patient presenting with a myasthenic crisis postthymectomy. (25695921)
2015
4
A rare case of mixed type a thymoma and micronodular thymoma with lymphoid stroma. (25812662)
2015
5
Histologic classification of thymoma: a practical guide for routine cases. (25396309)
2014
6
Thymoma complicated by acquired amegakaryocytic thrombocytopenia and pure red cell aplasia. (25361796)
2014
7
Presence of autoimmune regulator and absence of desmoglein 1 in thymoma associated with a pemphigus foliaceus patient. (25523433)
2014
8
Extended Surgical Resections of Advanced Thymoma Masaoka Stages III and IVa Facilitate Outcome. (23775415)
2013
9
Imaging of a case of metaplastic thymoma on 18F-FDG PET/CT. (24212449)
2013
10
Characterization of malignant thrombus in an invasive thymoma with intravascular growth. (23705036)
2013
11
Port-site recurrence after complete resection of stage I thymoma by video-assisted thoracoscopic surgery: report of a case. (24241478)
2013
12
Thymoma: current diagnosis and treatment. (23769581)
2013
13
Teaching Video NeuroImages: myokymia and nerve hyperexcitability as components of Morvan syndrome due to malignant thymoma. (23359380)
2013
14
V-AKT murine thymoma viral oncogene homolog/mammalian target of rapamycin activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis. (22271091)
2012
15
Evaluation of the role of radiation therapy in the management of malignant thymoma. (21596484)
2012
16
Pulmonary metastasis from encapsulated cervical ectopic type a thymoma. (23176955)
2012
17
Unusual cause of cardiac compression in a trauma patient: cystic thymoma. (23358097)
2012
18
Expression of P120 catenin, Kaiso, and metastasis tumor antigen-2 in thymomas. (22833212)
2012
19
Management and outcomes of relapse after treatment for thymoma and thymic carcinoma. (22115206)
2011
20
Thymoma: inter-relationships among World Health Organization histology, Masaoka staging and myasthenia gravis and their independent prognostic significance: a single-centre experience. (21093283)
2011
21
Computed tomography findings predicting invasiveness of thymoma. (21623235)
2011
22
Thymoma associated with malignancies may herald a hereditary cancer syndrome. (20734236)
2010
23
The occurrence of stiff person syndrome in a patient with thymoma: case report and literature review. (20509396)
2010
24
Spontaneous regression of an invasive thymoma. (20401719)
2010
25
Thymoma: Results of treatment and role of radiotherapy. (24376917)
2010
26
Bilateral exophthalmos in a rabbit. Diagnosis: Thymoma. (20729825)
2010
27
Cancer-associated retinopathy caused by benign thymoma. (20424218)
2010
28
Imatinib mesylate in patients with WHO B3 thymomas and thymic carcinomas. (20197733)
2009
29
Giant cystic thymoma with haemorrhage and necrosis: an unusual case. (19445448)
2009
30
An unusual case of malignant thymoma associated graft-versus-host disease. (21853007)
2009
31
Association between thymoma and persistent hypothermia: a case report. (19946549)
2009
32
The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis. (19693092)
2009
33
Thymomas: a cytological and immunohistochemical study, with emphasis on lymphoid and neuroendocrine markers. (17498299)
2007
34
Expression of autoimmune regulator gene (AIRE) and T regulatory cells in human thymomas. (17590173)
2007
35
Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1). (17334980)
2007
36
Pure red cell aplasia with malignant thymoma: a rarity. (17183851)
2006
37
Malignant thymoma associated with fatal myocarditis and polymyositis in a 32-year-old woman with a history of hairy cell leukemia. (16601447)
2006
38
Malignant melanoma of mediastinum misdiagnosed as a spindle cell thymoma in a fine needle aspirate: a case report. (16124173)
2005
39
Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia. (12515721)
2003
40
Serum level of the periostin, a homologue of an insect cell adhesion molecule, in thymoma patients. (11595127)
2001
41
Autocrine motility factor receptor expression associates with tumor progression in thymoma. (10891533)
2000
42
Thymoma and thymic carcinoma. (10366159)
1999
43
Resolution of exfoliative dermatitis and Malassezia pachydermatis overgrowth in a cat after surgical thymoma resection. (9358405)
1997
44
A new mouse gene, SRG3, related to the SWI3 of Saccharomyces cerevisiae, is required for apoptosis induced by glucocorticoids in a thymoma cell line. (9151708)
1997
45
Successful treatment of a patient with a thymoma and pure red-cell aplasia with octreotide and prednisone. (8995089)
1997
46
Oncogene proteins and proliferation antigens in thymomas: increased expression of epidermal growth factor receptor and Ki67 antigen. (7629292)
1995
47
Tissue distribution of very late activation antigens-1/6 and very late activation antigen ligands in the normal thymus and in thymoma. (8456937)
1993
48
Acute intestinal pseudo-obstruction due to malignant thymoma. (8266165)
1993
49
Thymic carcinosarcoma associated with a spindle cell thymoma: an immunohistochemical study. (1398523)
1992
50
Androgen therapy for refractory anemia: report of a case associated with thymoma. (13760488)
1960

Variations for Thymoma

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Expression for genes affiliated with Thymoma

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Search GEO for disease gene expression data for Thymoma.

Pathways for genes affiliated with Thymoma

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Pathways related to Thymoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 109)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7AKT2, AKT3, AKT1
2
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
9.7AKT2, AKT1, AKT3
39.7AKT2, AKT3, AKT1
4
Show member pathways
Development A2B receptor action via G protein alpha s58
9.7AKT2, AKT3, AKT1
5
Show member pathways
Development Flt3 signaling58
9.7AKT2, AKT1, AKT3
69.7AKT2, AKT3, AKT1
79.7AKT1, AKT3, AKT2
8
Show member pathways
9.7AKT3, AKT1, AKT2
9
Show member pathways
IFN-gamma pathway36
9.7AKT2, AKT1, AKT3
10
Show member pathways
Immune response IL 3 activation and signaling pathway58
9.7AKT3, AKT1, AKT2
11
Show member pathways
9.7AKT3, AKT2, AKT1
12
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.7AKT3, AKT1, AKT2
139.7AKT2, AKT3, AKT1
149.7AKT1, AKT3, AKT2
15
Show member pathways
9.7AKT2, AKT3, AKT1
16
Show member pathways
Development A1 receptor signaling58
G protein signaling G Protein alpha q signaling cascades58
9.7AKT2, AKT3, AKT1
17
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.7AKT3, AKT1, AKT2
18
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis58
9.7AKT2, AKT3, AKT1
199.7AKT1, AKT3, AKT2
209.7AKT2, AKT1, AKT3
219.7AKT1, AKT3, AKT2
22
Show member pathways
9.7AKT2, AKT3, AKT1
23
Show member pathways
Cell cycle ESR1 regulation of G1 S transition58
Immune response MIF JAB1 signaling58
Cell cycle Cell cycle generic schema 58
9.7AKT2, AKT3, AKT1
249.7AKT1, AKT2, AKT3
25
Show member pathways
DNA damage Role of SUMO in p53 regulation58
9.7AKT3, AKT2, AKT1
26
Show member pathways
9.7AKT1, AKT3, AKT2
279.7AKT3, AKT1, AKT2
28
Show member pathways
9.7AKT1, AKT2, AKT3
299.7AKT1, AKT3, AKT2
309.7AKT1, AKT3, AKT2
319.7AKT2, AKT1, AKT3
32
Show member pathways
9.7AKT3, AKT2, AKT1
33
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling58
9.7AKT2, AKT3, AKT1
349.7AKT1, AKT3, AKT2
359.7AKT2, AKT3, AKT1
369.7AKT2, AKT3, AKT1
379.7AKT3, AKT1, AKT2
38
Show member pathways
9.7AKT2, AKT1, AKT3
39
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades58
9.7AKT2, AKT3, AKT1
40
Show member pathways
9.4TNFRSF4, AKT2, AKT3, AKT1
41
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility58
Cytoskeleton remodeling Integrin outside in signaling58
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases58
Cell adhesion Tight junctions58
Development MAG dependent inhibition of neurite outgrowth58
9.2NKX2-1, AKT3, AKT2, AKT1
42
Show member pathways
9.1AKT2, AKT1, AKT3, RYR1
43
Show member pathways
Development Beta adrenergic receptors regulation of ERK58
G protein signaling G Protein alpha s signaling cascades58
G protein signaling G Protein beta gamma signaling cascades58
9.1RYR1, AKT1, AKT3, AKT2
44
Show member pathways
9.0AKT2, TNFRSF4, AKT1, CD2, AKT3
45
Show member pathways
9.0AKT3, AKT1, AKT2, TNFRSF4, CD2
46
Show member pathways
8.9AKT3, AKT1, AKT2, CTLA4
47
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.9AKT1, AKT2, AKT3, CTLA4
48
Show member pathways
8.9AKT1, AKT3, AKT2, CTLA4
49
Show member pathways
8.9AKT1, AKT3, AKT2, CTLA4
50
Show member pathways
8.6AKT3, AKT1, AKT2, CTLA4, AIRE

Compounds for genes affiliated with Thymoma

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Compounds related to Thymoma according to GeneCards Suite gene sharing:

(show all 23)
idCompoundScoreTop Affiliating Genes
1sc 795910.1AKT1, AKT3, AKT2
2fpa 1245910.1AKT2, AKT3, AKT1
310-debc hydrochloride5910.1AKT2, AKT3, AKT1
4api-15910.0AKT2, AKT3, AKT1
5api-25910.0AKT1, AKT3, AKT2
6sodium iodide439.7NKX2-1, SSTR2
7sb 20358043 5910.7AIRE, AKT2, AKT1
8ouabain43 1210.6RYR1, AKT1
9con a439.3CTLA4, CD2
10gnrh439.3AKT1, SSTR2, NKX2-1
11tamoxifen43 49 28 1212.2AKT2, AKT1, SSTR2
12ly294002439.2CTLA4, AKT1, AKT3, AKT2
13ionomycin439.1CTLA4, CD2, TNFRSF4
14paraffin439.0AKT1, SSTR2, NKX2-1, CD5
15wortmannin439.0AKT2, AKT1, CD2, CTLA4
16rapamycin438.8AKT2, AKT1, CTLA4, RYR1
17phosphatidylinositol438.8CTLA4, AKT1, AKT3, AKT2
18threonine438.6AKT2, AKT3, AKT1, NKX2-1, CTLA4
19estrogen438.3AKT2, AKT1, SSTR2, NKX2-1, CTLA4
20lipid438.2AKT2, AKT3, AKT1, CD2, CTLA4, RYR1
21glucose438.0AKT2, AKT1, SSTR2, CD2, CTLA4, RYR1
22serine437.8AIRE, AKT2, AKT3, AKT1, NKX2-1, CTLA4
23tyrosine437.4AIRE, AKT2, AKT1, SSTR2, NKX2-1, CD2

GO Terms for genes affiliated with Thymoma

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Cellular components related to Thymoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.5CTLA4, CD5, CD2, TNFRSF4
2integral component of plasma membraneGO:00058877.1RYR1, TNFRSF4, SSTR2, CD2, CD5, CTLA4
3plasma membraneGO:00058866.4AKT2, AKT3, AKT1, SSTR2, CD2, CD5

Biological processes related to Thymoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of plasma membrane long-chain fatty acid transportGO:001074810.1AKT1, AKT2
2positive regulation of glucose metabolic processGO:001090710.1AKT1, AKT2
3peripheral nervous system myelin maintenanceGO:003228710.0AKT2, AKT1
4mammary gland epithelial cell differentiationGO:006064410.0AKT1, AKT2
5positive regulation of glucose importGO:004632610.0AKT1, AKT2
6positive regulation of glycogen biosynthetic processGO:00457259.9AKT1, AKT2
7glycogen biosynthetic processGO:00059789.7AKT1, AKT2
8T cell costimulationGO:00312959.1CTLA4, CD5, AKT1

Molecular functions related to Thymoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:001630110.0AKT1, AKT2
2protein bindingGO:00055155.9RYR1, AIRE, AKT2, AKT3, AKT1, SSTR2

Products for genes affiliated with Thymoma

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Sources for Thymoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet