MCID: THY035
MIFTS: 39

Thyroid Adenoma malady

Endocrine diseases category
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Summaries for Thyroid Adenoma

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Wikipedia:65 A thyroid adenoma is a benign tumor of the thyroid gland. more...

MalaCards based summary: Thyroid Adenoma, also known as thyroid gland follicular adenoma, is related to adenoma and thyrotoxicosis. An important gene associated with Thyroid Adenoma is THADA (thyroid adenoma associated), and among its related pathways are Vasopressin-regulated water reabsorption and Ca-dependent events. The compounds propylthiouracil and iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and bone, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Thyroid Adenoma

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Sources:
10DISEASES, 44Novoseek, 62UMLS
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Thyroid Adenoma, Aliases & Descriptions:

Name: Thyroid Adenoma 10 44
 
Thyroid Gland Follicular Adenoma 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Related Diseases for Thyroid Adenoma

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Graphical network of the top 20 diseases related to Thyroid Adenoma:



Diseases related to thyroid adenoma

Symptoms for Thyroid Adenoma

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Drugs & Therapeutics for Thyroid Adenoma

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Drug clinical trials:

Search ClinicalTrials for Thyroid Adenoma

Search NIH Clinical Center for Thyroid Adenoma

Genetic Tests for Thyroid Adenoma

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Anatomical Context for Thyroid Adenoma

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MalaCards organs/tissues related to Thyroid Adenoma:

32
Thyroid, Pituitary, Bone, Testis

Animal Models for Thyroid Adenoma or affiliated genes

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MGI Mouse Phenotypes related to Thyroid Adenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7DIO2, TSHR, ADCY6, ADCY8, ADCY5

Publications for Thyroid Adenoma

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Articles related to Thyroid Adenoma:

(show top 50)    (show all 164)
idTitleAuthorsYear
1
HA1rthle cell thyroid adenoma with an eggshell calcification: Sonographic-pathologic correlation. (23913794)
2013
2
Development of Graves' disease following radioiodine treatment for autonomously functioning thyroid adenoma: case report. (22649896)
2011
3
Follicular thyroid adenoma with eggshell calcification presenting as an intensely hypermetabolic lesion on 18F-FDG PET/CT. (19655340)
2010
4
Autonomous thyroid adenoma: only an adulthood disease? (19446102)
2009
5
Immunohistochemical distinction of follicular thyroid adenomas and follicular carcinomas. (18559722)
2008
6
Eosinophilic fasciitis and toxic thyroid adenoma--a novel association. (18714852)
2008
7
A domain of the thyroid adenoma associated gene (THADA) conserved in vertebrates becomes destroyed by chromosomal rearrangements observed in thyroid adenomas. (17889454)
2007
8
Markers of cell proliferation, apoptosis, and angiogenesis in thyroid adenomas: a comparative immunohistochemical and genetic investigation of functioning and nonfunctioning nodules. (17381350)
2007
9
Toxic thyroid adenoma presenting as hypokalemic periodic paralysis. (17917308)
2007
10
Spindle cell metaplasia arising in thyroid adenoma: characterization of its pathology and differential diagnosis. (16610245)
2006
11
Ectopic mediastinal thyroid adenoma. (15201004)
2004
12
Radioiodine or surgery for toxic thyroid adenoma: dissecting an important decision. A cost-effectiveness analysis. (15671772)
2004
13
Antithyroid treatment changes thyroid scintigraphy in autonomous thyroid adenoma. (12699599)
2003
14
Association of hyperfunctioning thyroid adenoma with thyroid cancer presenting as "trapping only" nodule at 99mTcO4- scintigraphy. (15008253)
2003
15
Functional cystic thyroid adenoma in a cat. (11469573)
2001
16
Diagnosis and surgical treatment of thyroid adenoma-induced hyperthyroidism in a green iguana (Iguana iguana). (12785702)
2001
17
Black thyroid adenoma. Clinical, histochemical, and ultrastructural features. (10937053)
2000
18
Reverse discordant Tc-99m and I-131 imaging in a patient with a toxic thyroid adenoma. (10634532)
2000
19
Appearance of anti TSH-receptor antibodies and clinical Graves' disease after radioiodine therapy for hyperfunctioning thyroid adenoma. (10195384)
1999
20
Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways. (10534767)
1999
21
Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms. (10566665)
1999
22
Pathogenesis of toxic thyroid adenomas and nodules: relevance of activating mutations in the TSH-receptor and Gs-alpha gene, the possible role of iodine deficiency and secondary and TSH-independent molecular mechanisms. (9867188)
1998
23
Graves' disease after percutaneous ethanol injection for the treatment of autonomous thyroid adenoma. (9648057)
1998
24
Hyperfunctioning thyroid adenoma concomitant with papillary thyroid carcinoma, follicular thyroid adenoma and primary hyperparathyroidism. (9625447)
1998
25
Clinical and genetic analysis of an inherited case of thyroid adenoma/cancer. (9368503)
1997
26
Telomerase activity: a marker to distinguish follicular thyroid adenoma from carcinoma. (9187112)
1997
27
Autonomous thyroid adenoma, papillary thyroid carcinoma, and ectopic parathyroid adenoma in a patient with primary hyperparathyroidism and a nontoxic multinodular goiter. (9227878)
1997
28
Oncogenic mutations in thyroid adenoma: methodological criteria. (8921827)
1996
29
Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades. (8592518)
1995
30
Electrochemical therapy (ECT) for thyroid adenoma during acupuncture anaesthesia: analysis of 46 patients. (7531029)
1994
31
Unusual scintigraphic findings in a thyroid adenoma. (8441041)
1993
32
Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. (8413627)
1993
33
Percutaneous intranodular ethanol injection: a new treatment for autonomous thyroid adenoma. (1506620)
1992
34
Antibodies to the ganglioside GD1b in a patient with motor neuron disease and thyroid adenoma. (1953407)
1991
35
Plasma fibronectin level in patients with functional thyroid adenoma. (2117837)
1990
36
Scintigraphic demonstration of ectopic autonomously functioning thyroid adenoma with normal cervical thyroid. (2318002)
1990
37
Thyroid adenoma following treatment of acute lymphocytic leukemia. (2198824)
1990
38
Expression of keratin 19 distinguishes papillary thyroid carcinoma from follicular carcinomas and follicular thyroid adenoma. (2479256)
1989
39
Trabecular thyroid adenoma. (3421418)
1988
40
Pleomorphic atypical thyroid adenoma arising in struma testis: light microscopic, ultrastructural and immunofluorescent studies. (7045638)
1982
41
A new familial cancer syndrome? A spectrum of malignant and benign tumors including retinoblastoma, carcinoma of the bladder and other genitourinary tumors, thyroid adenoma, and a probable case of multifocal osteosarcoma. (264592)
1977
42
Association of autonomous thyroid adenoma with chronic thyroiditis. (594631)
1977
43
Solitary hyperfunctioning thyroid adenoma in a child. Elevated T3 and T4 levels with normal TSH level. (1242753)
1975
44
Studies of calcitonin content in thyroid adenoma and goiter. (4677950)
1972
45
Assay of C-cell thyroid adenoma of man for calcitonin activity. (4631209)
1972
46
THE SURVIVAL OF RICKETTSIA PROWAZEKI IN THYROID ADENOMA OF A TYPHUS-LABORATORY WORKER. (14313642)
1965
47
The value of isotope scanning in the problem of the solitary thyroid adenoma. (13689082)
1961
48
Protean manifestations of hyperparathyroidism: report of a case with coexistent refractory gastric ulcer and metastatic thyroid adenoma. (13600716)
1958
49
The problem of the thyroid adenoma. (13064669)
1953
50
Radioactive iodine in the diagnosis and treatment of lingual thyroid adenoma. (12982012)
1952

Variations for Thyroid Adenoma

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Expression for genes affiliated with Thyroid Adenoma

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Expression patterns in normal tissues for genes affiliated with Thyroid Adenoma

Search GEO for disease gene expression data for Thyroid Adenoma.

Pathways for genes affiliated with Thyroid Adenoma

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Pathways related to Thyroid Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2ADCY3, ADCY9, ADCY6
2
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
38.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
4
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
5
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
6
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
7
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
8
Show member pathways
Calcium Regulation in the Cardiac Cell37
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
9
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
108.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
11
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
12
Show member pathways
UTP and CTP dephosphorylation II37
ATP ITP metabolism60
purine deoxyribonucleosides salvage37
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
13
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
14
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
15
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
16
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
17
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
18
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
19
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
20
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
21
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
22
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
23
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
24
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
25
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
268.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
278.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
28
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
29
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
308.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
31
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
328.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
338.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
348.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
358.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
36
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
378.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
38
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
39
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
408.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
418.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
42
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
43
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
44
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
45
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
46
Show member pathways
Signal transduction cAMP signaling60
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
47
Show member pathways
7.3TSHR, ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
48
Show member pathways
7.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6, TSHR
497.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6, TSHR
50
Show member pathways
7.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6, TSHR

Compounds for genes affiliated with Thyroid Adenoma

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Compounds related to Thyroid Adenoma according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1111.3TSHR, DIO2
2iodine44 2410.2DIO2, TSHR
3125i449.2DIO2, TSHR
4iodide44 2410.1DIO2, TSHR
5triiodothyronine449.1DIO2, TSHR
6methimazole44 2 1111.0TSHR, DIO2
7dopamine44 28 24 1111.8DIO2, ADCY6, ADCY5
8nkh 477618.5ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
9pacap 1-27618.5ADCY8, ADCY5, ADCY3, ADCY9, ADCY6
10mdl 12330a hydrochloride618.4ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
11kh 7618.4ADCY3, ADCY6, ADCY9, ADCY8, ADCY5
12sq 2253644 619.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
13Cyclic GMP248.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
14Pyruvic acid24 119.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
15nad28 249.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
16phosphoric acid44 249.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
17pyrophosphate44 249.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
18nadh44 24 1110.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
19Guanosine triphosphate248.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
20magnesium44 24 1110.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
21Adenosine triphosphate24 119.3ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
22adenylate448.1ADCY3, ADCY5, ADCY9, ADCY6, TSHR
23forskolin44 50 1110.0ADCY3, ADCY5, ADCY9, TSHR, DIO2
24cyclic amp44 248.6ADCY3, ADCY5, ADCY8, ADCY9, ADCY6, TSHR
25calcium44 50 24 1110.0ADCY3, ADCY5, ADCY8, ADCY9, ADCY6, TSHR

GO Terms for genes affiliated with Thyroid Adenoma

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Cellular components related to Thyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ciliumGO:0059299.4ADCY6, ADCY3
2membraneGO:0160209.0DIO2, ADCY6, ADCY8
3plasma membraneGO:0058866.6DIO2, ADCY3, ADCY5, ADCY8, ADCY9, ADCY6

Biological processes related to Thyroid Adenoma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1activation of protein kinase A activityGO:0341998.4ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
2cellular response to glucagon stimulusGO:0713778.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
3adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071898.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
4water transportGO:0068338.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
5adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:0071938.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
6activation of phospholipase C activityGO:0072028.3ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
7energy reserve metabolic processGO:0061128.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
8fibroblast growth factor receptor signaling pathwayGO:0085438.3ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
9epidermal growth factor receptor signaling pathwayGO:0071738.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
10neurotrophin TRK receptor signaling pathwayGO:0480118.2ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
11intracellular signal transductionGO:0355568.2ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
12synaptic transmissionGO:0072688.2ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
13transmembrane transportGO:0550858.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
14signal transductionGO:0071658.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
15innate immune responseGO:0450877.8ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
16small molecule metabolic processGO:0442817.5ADCY3, ADCY5, ADCY8, ADCY9, ADCY6, DIO2

Molecular functions related to Thyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metal ion bindingGO:0468728.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
2adenylate cyclase activityGO:0040168.0ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
3ATP bindingGO:0055247.8ADCY3, ADCY5, ADCY8, ADCY9, ADCY6

Products for genes affiliated with Thyroid Adenoma

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  • Antibodies
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Sources for Thyroid Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet