MCID: THY035
MIFTS: 32

Thyroid Adenoma malady

Endocrine diseases category

Summaries for Thyroid Adenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A thyroid adenoma is a benign tumor of the thyroid gland. more...

MalaCards: Thyroid Adenoma, also known as thyroid gland follicular adenoma, is related to thyroiditis and adenoma. An important gene associated with Thyroid Adenoma is THADA (thyroid adenoma associated), and among its related pathways are G-Beta Gamma Signaling and Calcium signaling pathway. The compounds 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE and 125i have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Thyroid Adenoma

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10DISEASES, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

thyroid adenoma 10 44
thyroid gland follicular adenoma 60


Related Diseases for Thyroid Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Thyroid Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.6SERPINA7, TSHR
2adenoma31.6CNC, ADCY1, TSHR, PAX8, LGALS3, PRKAR1A
3follicular adenoma30.9TSHR, LGALS3, PAX8, DIO2, GNAS
4graves' disease30.6TSHR, GNAS
5follicular thyroid carcinoma30.6LGALS3, TSHR, PAX8, DIO2
6hyperthyroidism30.6GNAS, DIO2, SERPINA7, TSHR
7goiter30.5SERPINA7, GNAS, TSHR, LGALS3, PAX8, DIO2
8papillary carcinoma30.4GNAS, PAX8, LGALS3, TSHR
9papillary thyroid carcinoma30.4LGALS3, PAX8, TSHR
10thyroid cancer30.4LGALS3, PAX8, PRKAR1A, GNAS, TSHR
11autoimmune thyroiditis30.3SERPINA7, LGALS3, TSHR
12thyrotoxicosis30.1SERPINA7, TSHR
13parathyroid adenoma30.1PRKAR1A, GNAS, LGALS3
14pituitary adenoma30.1LGALS3, SERPINA7, GNAS, PRKAR1A, CNC
15congenital hypothyroidism29.9SERPINA7, PAX8, TSHR, GNAS
16hypothyroidism29.9TSHR, SERPINA7, PAX8, DIO2, GNAS
17wermer syndrome29.9PRKAR1A
18acromegaly29.9GNAS, CNC, PRKAR1A
19papillary adenoma10.3
20hyperparathyroidism10.3
21multinodular goiter10.3
22primary hyperparathyroidism10.2
23osteoporosis10.1
24cervicitis10.1
25laryngitis10.1
26thyroid adenoma, hyperfunctioning, somatic10.1
27colorectal cancer10.0LGALS3
28breast cancer10.0PRKAR1A, LGALS3
29diabetes mellitus10.0GNB3
30mccune albright syndrome10.0GNAS, PRKAR1A, ADCY2
31pseudohypoparathyroidism10.0ADCY2, GNAS
32carney complex10.0PRKAR1A, GNAS
33endemic goiter10.0TSHR
34obesity10.0GNB3, DIO2, GNAS
35adrenal adenoma10.0PRKAR1A, CNC, GNAS
36thyroid agenesis10.0PAX8, TSHR, SERPINA7, LGALS3
37thyroid cancer, anaplastic10.0TSHR, LGALS3, PAX8
38insulin resistance10.0GNAS, GNB3, DIO2
39acrodysostosis10.0PRKAR1A, GNAS
40cushing's syndrome10.0GNAS, CNC, PRKAR1A
41euthyroid sick syndrome10.0SERPINA7
42ovarian cyst10.0CNC, GNAS
43hyperthyroxinemia10.0TSHR, SERPINA7
44pituitary tumors10.0PRKAR1A, CNC, LGALS3, GNAS
45pendred syndrome10.0PAX8
46nodular goiter10.0TSHR, LGALS3
47cholera10.0ADCY8, ADCY3, ADCY6, ADCY2, ADCY1, ADCY4
48adrenal gland hyperfunction10.0PRKAR1A, CNC
49nontoxic goiter10.0
50acute thyroiditis10.0

Graphical network of the top 20 diseases related to Thyroid Adenoma:



Diseases related to thyroid adenoma

Clinical Features for Thyroid Adenoma

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Drugs & Therapeutics for Thyroid Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Thyroid Adenoma

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Anatomical Context for Thyroid Adenoma

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32MalaCards
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MalaCards organs/tissues related to Thyroid Adenoma:

32
Thyroid

Animal Models for Thyroid Adenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thyroid Adenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9ADCY8, DIO2, PRKAR1A, PAX8, LGALS3, TSHR

Publications for Thyroid Adenoma

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Genetic Variations for Thyroid Adenoma

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Expression for genes affiliated with Thyroid Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroid Adenoma

Search GEO for disease gene expression data for Thyroid Adenoma.

Pathways for genes affiliated with Thyroid Adenoma

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 49PharmGKB
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Pathways related to Thyroid Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0GNB3, PRKAR1A, ADCY7, ADCY3, ADCY6, ADCY2
29.9GNAS, ADCY7, ADCY3, ADCY2, ADCY9, ADCY1
3
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9.9ADCY8, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
49.9ADCY6, ADCY3, ADCY7, ADCY2, ADCY9, ADCY4
59.9ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
69.9ADCY7, ADCY3, ADCY4, ADCY8, ADCY1, ADCY5
79.9ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
8
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9.9ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
9
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9.9ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
10
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9.8GNAS, GNB3, ADCY7, ADCY3, ADCY6, ADCY2
11
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9.8GNAS, GNB3, TSHR, ADCY7, ADCY3, ADCY6
12
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9.8ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
139.8ADCY2, ADCY6, ADCY3, ADCY7, GNAS, ADCY9
14
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9.8ADCY8, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
159.8ADCY1, ADCY5, ADCY9, ADCY2, ADCY6, ADCY3
169.8ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
17
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9.8GNAS, ADCY7, ADCY4, ADCY8, ADCY1, ADCY5
18
Development Endothelin-1/EDNRA signaling
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9.8ADCY4, GNAS, ADCY8, ADCY1, ADCY5, ADCY9
199.8ADCY8, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
209.8ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
219.8ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
22
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9.8ADCY3, ADCY7, PRKAR1A, GNB3, GNAS, ADCY6
23
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9.8ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
24
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9.8ADCY6, ADCY3, ADCY7, PRKAR1A, ADCY2, ADCY9
259.8PRKAR1A, ADCY7, ADCY3, ADCY6, ADCY2, ADCY9
26
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9.8LGALS3, ADCY7, ADCY4, ADCY8, ADCY1, ADCY5
27
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9.8ADCY9, ADCY2, ADCY6, ADCY3, ADCY7, GNB3
28
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9.8ADCY6, ADCY3, ADCY7, GNB3, ADCY2, ADCY9
29
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9.8GNB3, ADCY7, ADCY3, ADCY6, ADCY2, ADCY9
30
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9.8ADCY6, ADCY3, ADCY7, GNB3, ADCY2, ADCY9
31
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9.8GNAS, ADCY5, ADCY9, ADCY2, ADCY6, ADCY3
32
Hide members
9.8ADCY8, ADCY1, GNAS, ADCY5, ADCY9, ADCY2
33
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9.8ADCY8, GNAS, GNB3, ADCY1, ADCY5, ADCY9
34
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
9.8GNAS, PRKAR1A, ADCY7, ADCY4, ADCY8, ADCY1
359.8ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
36
Hide members
9.8ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
37
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9.8ADCY3, ADCY7, PRKAR1A, GNB3, ADCY6, ADCY2
38
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9.8ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
39
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9.8GNB3, PRKAR1A, ADCY7, ADCY3, ADCY6, ADCY2
40
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9.8ADCY3, ADCY7, PRKAR1A, GNB3, ADCY6, ADCY2
41
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9.8ADCY3, ADCY7, PRKAR1A, GNB3, ADCY6, ADCY2
42
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9.8ADCY3, ADCY7, PRKAR1A, GNB3, ADCY6, ADCY2
439.8ADCY1, ADCY5, ADCY9, ADCY2, ADCY6, ADCY3
449.8ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
45
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9.8ADCY6, ADCY3, ADCY7, PRKAR1A, ADCY2, ADCY9
46
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9.7ADCY7, PRKAR1A, GNB3, GNAS, ADCY3, ADCY6
47
G-protein signaling G-Protein alpha-i signaling cascades
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9.7ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
48
Hide members
9.7ADCY6, ADCY3, ADCY7, PRKAR1A, GNB3, GNAS
49
Hide members
9.7ADCY2, ADCY6, ADCY3, ADCY7, PRKAR1A, GNB3
50
Signal transduction cAMP signaling
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9.7ADCY4, GNAS, GNB3, PRKAR1A, ADCY8, ADCY1

Compounds for genes affiliated with Thyroid Adenoma

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Sources:
11DrugBank, 44Novoseek, 24HMDB, 2BitterDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Thyroid Adenoma according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
12',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE1110.6GNAS, ADCY5, ADCY2
2125i4410.6TSHR, SERPINA7, DIO2
3iodide44 2411.6DIO2, PAX8, SERPINA7, TSHR
4iodine44 2411.6GNAS, TSHR, SERPINA7, DIO2
5methimazole44 2 1112.5TSHR, SERPINA7, DIO2
6thyroxine44 2411.5SERPINA7, TSHR, DIO2, PAX8
7sialic acid4410.5TSHR, GNAS, SERPINA7, LGALS3
8ribonucleic acid4410.5PAX8, TSHR, SERPINA7, GNAS, DIO2
9triiodothyronine4410.5DIO2, SERPINA7, TSHR
10acth4410.4GNAS, LGALS3, SERPINA7, TSHR, ADCY1
11isoproterenol44 1111.4ADCY2, ADCY1, ADCY3, GNAS, ADCY7
12glucose4410.4TSHR, DIO2, SERPINA7
13sodium iodide4410.4PAX8, TSHR
14Liothyronine11 2411.4SERPINA7, DIO2
15dopamine44 28 11 2413.3GNAS, GNB3, DIO2, SERPINA7, ADCY5, ADCY6
16nkh 4775910.3ADCY4, ADCY6, ADCY3, ADCY7, ADCY2, ADCY9
17threonine4410.3DIO2, LGALS3, SERPINA7, GNAS, PAX8, TSHR
18sq 2253659 4411.3ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
19kh 75910.3ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
20mdl 12330a hydrochloride5910.3ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
21Pyruvic acid11 2411.3ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
22pacap 1-275910.3ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
23arginine4410.3SERPINA7, ADCY1, LGALS3, PRKAR1A, GNAS, TSHR
24nad28 2411.3ADCY3, ADCY6, ADCY2, ADCY5, ADCY4, ADCY8
25phosphoric acid44 2411.3ADCY5, ADCY1, ADCY6, ADCY4, ADCY8, ADCY9
26nadh44 11 2412.3ADCY5, ADCY1, ADCY8, ADCY4, ADCY2, ADCY6
27adenylate4410.3ADCY1, ADCY6, ADCY5, ADCY9, ADCY2, GNAS
28pyrophosphate44 2411.3ADCY3, ADCY7, ADCY2, ADCY5, ADCY1, ADCY8
29progesterone44 59 28 11 2414.3TSHR, GNAS, LGALS3, SERPINA7, ADCY1
30Adenosine triphosphate11 2411.2ADCY6, ADCY2, ADCY9, ADCY5, ADCY1, ADCY8
31asparagine4410.2TSHR, SERPINA7, GNAS
32magnesium44 11 2412.2ADCY5, ADCY8, PRKAR1A, ADCY1, ADCY4, ADCY7
33forskolin44 49 1112.2ADCY9, TSHR, DIO2, PRKAR1A, ADCY3, ADCY7
34propylthiouracil44 2 1112.1TSHR, DIO2
35cyclic amp44 2411.0GNAS, PRKAR1A, CNC, TSHR, ADCY7, ADCY3
36calcium44 49 11 2412.9ADCY5, ADCY2, ADCY1, LGALS3, ADCY6, ADCY3

GO Terms for genes affiliated with Thyroid Adenoma

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16Gene Ontology
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Cellular components related to Thyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:01602010.1ADCY4, ADCY8, ADCY2, ADCY6, DIO2, GNAS
2plasma membraneGO:0058869.2ADCY4, GNAS, GNB3, DIO2, PRKAR1A, LGALS3

Biological processes related to Thyroid Adenoma according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.4ADCY5, GNAS
2cellular response to catecholamine stimulusGO:07187010.3ADCY6, GNAS
3cAMP biosynthetic processGO:00617110.2GNAS, ADCY6, ADCY2, ADCY1, ADCY4
4adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.2ADCY6, ADCY3, ADCY7, ADCY4, ADCY8, ADCY1
5adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.2ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
6activation of phospholipase C activityGO:00720210.2ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
7fibroblast growth factor receptor signaling pathwayGO:00854310.1ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
8activation of protein kinase A activityGO:03419910.1PRKAR1A, ADCY7, ADCY3, ADCY4, ADCY8, ADCY1
9epidermal growth factor receptor signaling pathwayGO:00717310.1PRKAR1A, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
10cellular response to prostaglandin E stimulusGO:07138010.1ADCY6, GNAS
11intracellular signal transductionGO:03555610.1ADCY4, PRKAR1A, ADCY7, ADCY3, ADCY6, ADCY2
12neurotrophin TRK receptor signaling pathwayGO:04801110.0ADCY8, PRKAR1A, ADCY3, ADCY2, ADCY9, ADCY7
13water transportGO:00683310.0ADCY8, ADCY4, GNAS, PRKAR1A, ADCY7, ADCY3
14synaptic transmissionGO:00726810.0GNB3, ADCY8, ADCY9, ADCY4, ADCY1, ADCY5
15cellular response to glucagon stimulusGO:07137710.0ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
16transmembrane transportGO:05508510.0ADCY4, ADCY8, ADCY1, ADCY5, ADCY2, ADCY6
17energy reserve metabolic processGO:00611210.0ADCY2, ADCY6, ADCY3, ADCY7, PRKAR1A, GNB3
18innate immune responseGO:0450879.9ADCY5, LGALS3, ADCY3, ADCY6, ADCY2, ADCY9
19signal transductionGO:0071659.8ADCY6, ADCY3, ADCY7, PRKAR1A, ADCY2, ADCY9
20small molecule metabolic processGO:0442819.7ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2

Molecular functions related to Thyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase bindingGO:00817910.3ADCY5, ADCY2
2calcium- and calmodulin-responsive adenylate cyclase activityGO:00829410.3ADCY1, ADCY2, ADCY8
3thyroid-stimulating hormone receptor activityGO:00499610.1PAX8, TSHR
4adenylate cyclase activityGO:00401610.0ADCY4, GNAS, ADCY7, ADCY3, ADCY6, ADCY2
5metal ion bindingGO:0468729.8ADCY6, ADCY7, ADCY4, ADCY8, ADCY1, ADCY5
6ATP bindingGO:0055249.8ADCY6, ADCY4, ADCY8, ADCY1, ADCY5, ADCY9

Products for genes affiliated with Thyroid Adenoma

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  • Antibodies
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Sources for Thyroid Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet