MCID: THY035
MIFTS: 39

Thyroid Adenoma malady

Endocrine diseases category

Summaries for Thyroid Adenoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 A thyroid adenoma is a benign tumor of the thyroid gland. more...

MalaCards: Thyroid Adenoma, also known as thyroid gland follicular adenoma, is related to adenoma and hyperthyroidism. An important gene associated with Thyroid Adenoma is THADA (thyroid adenoma associated), and among its related pathways are Vasopressin-regulated water reabsorption and Ca-dependent events. The compounds propylthiouracil and iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and bone, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Thyroid Adenoma

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11DISEASES, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

thyroid adenoma 11 46
thyroid gland follicular adenoma 63


Related Diseases for Thyroid Adenoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Thyroid Adenoma:



Diseases related to thyroid adenoma

Symptoms for Thyroid Adenoma

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Drugs & Therapeutics for Thyroid Adenoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Thyroid Adenoma

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Anatomical Context for Thyroid Adenoma

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34MalaCards
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MalaCards organs/tissues related to Thyroid Adenoma:

34
Thyroid, Pituitary, Bone, Testis

Animal Models for Thyroid Adenoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Thyroid Adenoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7DIO2, TSHR, ADCY6, ADCY8, ADCY5

Publications for Thyroid Adenoma

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53PubMed
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Articles related to Thyroid Adenoma:

(show top 50)    (show all 162)
idTitleAuthorsYear
1
HA1rthle cell thyroid adenoma with an eggshell calcification: Sonographic-pathologic correlation. (23913794)
2013
2
Development of Graves' disease following radioiodine treatment for autonomously functioning thyroid adenoma: case report. (22649896)
2011
3
Proliferation of a chronic thyroid adenoma. (22715225)
2011
4
Follicular thyroid adenoma with eggshell calcification presenting as an intensely hypermetabolic lesion on 18F-FDG PET/CT. (19655340)
2010
5
Autonomous thyroid adenoma: only an adulthood disease? (19446102)
2009
6
Immunohistochemical distinction of follicular thyroid adenomas and follicular carcinomas. (18559722)
2008
7
Eosinophilic fasciitis and toxic thyroid adenoma--a novel association. (18714852)
2008
8
A domain of the thyroid adenoma associated gene (THADA) conserved in vertebrates becomes destroyed by chromosomal rearrangements observed in thyroid adenomas. (17889454)
2007
9
Markers of cell proliferation, apoptosis, and angiogenesis in thyroid adenomas: a comparative immunohistochemical and genetic investigation of functioning and nonfunctioning nodules. (17381350)
2007
10
Toxic thyroid adenoma presenting as hypokalemic periodic paralysis. (17917308)
2007
11
Spindle cell metaplasia arising in thyroid adenoma: characterization of its pathology and differential diagnosis. (16610245)
2006
12
Ectopic mediastinal thyroid adenoma. (15201004)
2004
13
Radioiodine or surgery for toxic thyroid adenoma: dissecting an important decision. A cost-effectiveness analysis. (15671772)
2004
14
Antithyroid treatment changes thyroid scintigraphy in autonomous thyroid adenoma. (12699599)
2003
15
Association of hyperfunctioning thyroid adenoma with thyroid cancer presenting as "trapping only" nodule at 99mTcO4- scintigraphy. (15008253)
2003
16
Functional cystic thyroid adenoma in a cat. (11469573)
2001
17
Diagnosis and surgical treatment of thyroid adenoma-induced hyperthyroidism in a green iguana (Iguana iguana). (12785702)
2001
18
Black thyroid adenoma. Clinical, histochemical, and ultrastructural features. (10937053)
2000
19
Reverse discordant Tc-99m and I-131 imaging in a patient with a toxic thyroid adenoma. (10634532)
2000
20
Appearance of anti TSH-receptor antibodies and clinical Graves' disease after radioiodine therapy for hyperfunctioning thyroid adenoma. (10195384)
1999
21
Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways. (10534767)
1999
22
Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms. (10566665)
1999
23
Pathogenesis of toxic thyroid adenomas and nodules: relevance of activating mutations in the TSH-receptor and Gs-alpha gene, the possible role of iodine deficiency and secondary and TSH-independent molecular mechanisms. (9867188)
1998
24
Graves' disease after percutaneous ethanol injection for the treatment of autonomous thyroid adenoma. (9648057)
1998
25
Hyperfunctioning thyroid adenoma concomitant with papillary thyroid carcinoma, follicular thyroid adenoma and primary hyperparathyroidism. (9625447)
1998
26
Clinical and genetic analysis of an inherited case of thyroid adenoma/cancer. (9368503)
1997
27
Telomerase activity: a marker to distinguish follicular thyroid adenoma from carcinoma. (9187112)
1997
28
Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas. (9253356)
1997
29
Autonomous thyroid adenoma, papillary thyroid carcinoma, and ectopic parathyroid adenoma in a patient with primary hyperparathyroidism and a nontoxic multinodular goiter. (9227878)
1997
30
Oncogenic mutations in thyroid adenoma: methodological criteria. (8921827)
1996
31
Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades. (8592518)
1995
32
Electrochemical therapy (ECT) for thyroid adenoma during acupuncture anaesthesia: analysis of 46 patients. (7531029)
1994
33
Unusual scintigraphic findings in a thyroid adenoma. (8441041)
1993
34
Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. (8413627)
1993
35
Percutaneous intranodular ethanol injection: a new treatment for autonomous thyroid adenoma. (1506620)
1992
36
Antibodies to the ganglioside GD1b in a patient with motor neuron disease and thyroid adenoma. (1953407)
1991
37
Plasma fibronectin level in patients with functional thyroid adenoma. (2117837)
1990
38
Scintigraphic demonstration of ectopic autonomously functioning thyroid adenoma with normal cervical thyroid. (2318002)
1990
39
Thyroid adenoma following treatment of acute lymphocytic leukemia. (2198824)
1990
40
Trabecular thyroid adenoma. (3421418)
1988
41
Pleomorphic atypical thyroid adenoma arising in struma testis: light microscopic, ultrastructural and immunofluorescent studies. (7045638)
1982
42
A new familial cancer syndrome? A spectrum of malignant and benign tumors including retinoblastoma, carcinoma of the bladder and other genitourinary tumors, thyroid adenoma, and a probable case of multifocal osteosarcoma. (264592)
1977
43
Association of autonomous thyroid adenoma with chronic thyroiditis. (594631)
1977
44
Solitary hyperfunctioning thyroid adenoma in a child. Elevated T3 and T4 levels with normal TSH level. (1242753)
1975
45
Studies of calcitonin content in thyroid adenoma and goiter. (4677950)
1972
46
Assay of C-cell thyroid adenoma of man for calcitonin activity. (4631209)
1972
47
THE SURVIVAL OF RICKETTSIA PROWAZEKI IN THYROID ADENOMA OF A TYPHUS-LABORATORY WORKER. (14313642)
1965
48
The value of isotope scanning in the problem of the solitary thyroid adenoma. (13689082)
1961
49
The problem of the thyroid adenoma. (13064669)
1953
50
Radioactive iodine in the diagnosis and treatment of lingual thyroid adenoma. (12982012)
1952

Variations for Thyroid Adenoma

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Expression for genes affiliated with Thyroid Adenoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroid Adenoma

Search GEO for disease gene expression data for Thyroid Adenoma.

Pathways for genes affiliated with Thyroid Adenoma

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Sources:
51PathCards, 31KEGG, 56Reactome, 61Thomson Reuters, 54QIAGEN, 52PharmGKB, 39NCBI BioSystems Database, 13EMD Millipore
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Pathways related to Thyroid Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2ADCY3, ADCY9, ADCY6
2
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
38.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
4
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
5
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
6
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
7
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
8
Show member pathways
Calcium Regulation in the Cardiac Cell39
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
9
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
108.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
11
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
12
Show member pathways
UTP and CTP dephosphorylation II39
ATP ITP metabolism61
purine deoxyribonucleosides salvage39
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
13
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
14
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
15
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
16
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
17
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
18
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
19
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
20
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
21
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
22
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
23
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
24
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
25
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
268.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
278.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
28
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
29
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
308.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
31
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
328.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
338.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
348.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
358.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
36
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
378.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
38
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
39
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
408.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
418.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
42
Show member pathways
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
43
Show member pathways
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
44
Show member pathways
Development Beta adrenergic receptors regulation of ERK61
G protein signaling G Protein alpha s signaling cascades61
G protein signaling G Protein beta gamma signaling cascades61
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
45
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
8.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
46
Show member pathways
Signal transduction cAMP signaling61
8.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
47
Show member pathways
7.3TSHR, ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
48
Show member pathways
7.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6, TSHR
497.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6, TSHR
50
Show member pathways
7.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6, TSHR

Compounds for genes affiliated with Thyroid Adenoma

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Sources:
46Novoseek, 3BitterDB, 12DrugBank, 25HMDB, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB
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Compounds related to Thyroid Adenoma according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1propylthiouracil46 3 1211.3TSHR, DIO2
2iodine46 2510.2DIO2, TSHR
3125i469.2DIO2, TSHR
4iodide46 2510.1DIO2, TSHR
5triiodothyronine469.1DIO2, TSHR
6methimazole46 3 1211.0TSHR, DIO2
7dopamine46 30 25 1211.8DIO2, ADCY6, ADCY5
8nkh 477628.5ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
9pacap 1-27628.5ADCY8, ADCY5, ADCY3, ADCY9, ADCY6
10mdl 12330a hydrochloride628.4ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
11kh 7628.4ADCY3, ADCY6, ADCY9, ADCY8, ADCY5
12sq 2253646 629.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
13Cyclic GMP258.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
14Pyruvic acid25 129.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
15nad30 259.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
16phosphoric acid46 259.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
17pyrophosphate46 259.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
18nadh46 25 1210.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
19Guanosine triphosphate258.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
20magnesium46 25 1210.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
21Adenosine triphosphate25 129.3ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
22adenylate468.1ADCY3, ADCY5, ADCY9, ADCY6, TSHR
23forskolin46 52 1210.0ADCY3, ADCY5, ADCY9, TSHR, DIO2
24cyclic amp46 258.6ADCY3, ADCY5, ADCY8, ADCY9, ADCY6, TSHR
25calcium46 52 25 1210.0ADCY3, ADCY5, ADCY8, ADCY9, ADCY6, TSHR

GO Terms for genes affiliated with Thyroid Adenoma

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17Gene Ontology
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Cellular components related to Thyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ciliumGO:0059299.4ADCY6, ADCY3
2membraneGO:0160209.0DIO2, ADCY6, ADCY8
3plasma membraneGO:0058866.6DIO2, ADCY3, ADCY5, ADCY8, ADCY9, ADCY6

Biological processes related to Thyroid Adenoma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1activation of protein kinase A activityGO:0341998.4ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
2cellular response to glucagon stimulusGO:0713778.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
3adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071898.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
4water transportGO:0068338.4ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
5adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:0071938.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
6activation of phospholipase C activityGO:0072028.3ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
7energy reserve metabolic processGO:0061128.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
8fibroblast growth factor receptor signaling pathwayGO:0085438.3ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
9epidermal growth factor receptor signaling pathwayGO:0071738.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
10neurotrophin TRK receptor signaling pathwayGO:0480118.2ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
11intracellular signal transductionGO:0355568.2ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
12synaptic transmissionGO:0072688.2ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
13transmembrane transportGO:0550858.1ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
14signal transductionGO:0071658.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
15innate immune responseGO:0450877.8ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
16small molecule metabolic processGO:0442817.5ADCY3, ADCY5, ADCY8, ADCY9, ADCY6, DIO2

Molecular functions related to Thyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metal ion bindingGO:0468728.1ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
2adenylate cyclase activityGO:0040168.0ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
3ATP bindingGO:0055247.8ADCY3, ADCY5, ADCY8, ADCY9, ADCY6

Products for genes affiliated with Thyroid Adenoma

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Sources for Thyroid Adenoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet