Thyroid Adenoma malady

Wikipedia: A thyroid adenoma is a benign tumor of the thyroid gland.⁴⁴ more...

MalaCards: Thyroid Adenoma, also known as thyroid gland follicular adenoma, is related to hyperthyroidism and follicular adenoma. An important gene associated with Thyroid Adenoma is THADA (thyroid adenoma associated), and among its related pathways are Adenylate cyclase activating pathway and Adenylate cyclase-activating neuropeptides. The compounds nkh 477 and bpipp have been mentioned in the context of this disorder. Affiliated tissues include thyroid and pituitary, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

thyroid adenoma 7 8 32 thyroid gland follicular adenoma 43

Diseases related to thyroid adenoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 325)

id	Related Disease	Score	Top Affiliating Genes
1	hyperthyroidism	29.1	SERPINA7, BGLAP, PAX8, GNAS, TXNRD2, TRH
2	follicular adenoma	29.0	RET, LGALS3, TPO, PTEN, TG
3	multinodular goiter	27.6	GNAS, HRAS, TRH, TPO, SHBG, TSHR
4	thyroid carcinoma	27.2	PIK3CA, RET, BRAF, RAF1, RASSF1, BGLAP
5	goiter	26.9	RET, SERPINA7, BRAF, BGLAP, PAX8, LGALS3
6	adenoma	21.8	ZNF331, PIK3CA, PDE4A, RET, CNC, SERPINA7
7	thyroiditis	21.3	ZNF331, PIK3CA, PDE4A, RET, CNC, SERPINA7
8	carcinoma	17.8	PIK3CA, PDE4A, RET, CNC, SERPINA7, BRAF
9	acrodysostosis	13.7	APC, GNAS, PRKAR1A
10	toxic diffuse goiter	13.7	TPO, TSHR, TG
11	pendred syndrome	13.7	PAX8, TPO, DIO2, TG
12	colorectal cancer, somatic	13.7	PIK3CA, BRAF, APC
13	carney complex	13.7	CNC, GNAS, PTEN, PRKAR1A
14	odontogenic myxoma	13.6	CNC, GNAS, PRKAR1A
15	plummer's disease	13.6	TPO, SHBG, TG
16	wermer syndrome	13.6	RET, CNC, GNAS, PRKAR1A
17	myxedema	13.6	TPO, TSHR, TG
18	familial male-limited precocious puberty	13.6	APC, GNAS, SHBG, TSHR
19	thyroid agenesis	13.6	SERPINA7, PAX8, LGALS3, TSHR, TG
20	struma ovarii	13.6	RET, BRAF, TSHR, TG
21	thyroxine-binding globulin deficiency	13.6	SERPINA7, TG
22	thyrotoxic periodic paralysis	13.6	SCN4A, TPO, TSHR
23	neonatal thyrotoxicosis	13.6	TXNRD2, TRH, TSHR
24	cowden disease	13.6	PIK3CA, RET, CNC, PTEN
25	pseudohypoparathyroidism type ia	13.6	APC, GNAS, TRH
26	primary pigmented nodular adrenocortical disease	13.5	CNC, GNAS, PRKAR1A, PRKACA
27	total iodide organification defect	13.5	TPO, TG
28	iodine hypothyroidism	13.5	TPO, TG
29	hyperthyroxinemia	13.5	SERPINA7, TRH, TPO, TSHR
30	euthyroid sick syndrome	13.5	SERPINA7, TRH, DIO2
31	hashimoto's encephalitis	13.5	TPO, TG
32	adrenal hyperplasia	13.5	CNC, SERPINA7, GNAS, SHBG, PRKAR1A
33	nodular goiter	13.5	TRH, TPO, TSHR, TG
34	neuroendocrine tumor	13.5	RET, RAF1, RASSF1, PAX8, IFI27, GNAS
35	clear cell adenocarcinoma	13.5	PIK3CA, PAX8, IFI27, PTEN
36	endogenous depression	13.4	TRH, TPO, TG
37	peutz-jeghers syndrome	13.4	CNC, APC, PTEN, PRKAR1A
38	kidney cancer	13.4	PIK3CA, BRAF, RAF1, RASSF1
39	mucinoses	13.4	SERPINA7, TRH, TPO, TSHR, TG
40	endemic goiter	13.4	SERPINA7, TRH, TPO, TSHR, TG
41	atrophy of thyroid	13.4	TRH, TPO
42	cardiofaciocutaneous syndrome	13.4	BRAF, RAF1, HRAS
43	albright's hereditary osteodystrophy	13.4	APC, GNAS, ADCY10
44	neuroectodermal endocrine syndrome	13.4	RET, SERPINA7, GNAS, TRH, SHBG
45	diabetes insipidus	13.4	TRH, TPO, TSHR, TG, ADCY2
46	thyroid hormone resistance syndrome	13.4	SERPINA7, TXNRD2, TRH, SHBG, TG
47	pulmonic stenosis	13.3	BRAF, RAF1, HRAS
48	hypothyroidism	13.3	TRH, TPO, SHBG, TSHR, TG
49	thyroid medullary carcinoma	13.3	RET, BRAF, PAX8, LGALS3, TPO, TSHR
50	adrenal adenoma	13.3	CNC, GNAS, PRKAR1A, ADCY10

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to thyroid adenoma:

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MGI Mouse Phenotypes related to thyroid adenoma:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.0	PRKAR1A, TRH, FHL5, PAX8, RET, GNAS
2	hematopoietic system phenotype	MP:0005397	9.4	PRKAR1A, TG, APC, LGALS3, BRAF, BCL2
3	immune system phenotype	MP:0005387	9.2	DNASE1, RAF1, PRKAR1A, PDE4A, BRAF, ADCY9
4	no phenotypic analysis	MP:0003012	8.9	PAX8, MUC1, APC, GNAI1, GNAS, HRAS
5	reproductive system phenotype	MP:0005389	8.8	PIK3CA, PAX8, FHL5, APC, HRAS, TSHR
6	skeleton phenotype	MP:0005390	8.6	ITGB2, FLNB, APC, GNAS, HRAS, PTEN
7	adipose tissue phenotype	MP:0005375	8.6	BRAF, PIK3CA, BCL2, APC, GNAS, PTEN
8	renal/urinary system phenotype	MP:0005367	8.3	PAX8, BCL2, LGALS3, DIO2, PTEN, PPARG
9	tumorigenesis	MP:0002006	8.0	BRAF, RET, PIK3CA, BCL2, MUC1, APC
10	normal phenotype	MP:0002873	8.0	HRAS, ADCY3, PRKAR1A, RET, BRAF, LGALS1
11	muscle phenotype	MP:0005369	7.9	APC, LGALS1, SCN4A, RAF1, BRAF, RET
12	integument phenotype	MP:0010771	7.8	BRAF, GNAS, RAF1, MUC1, LGALS3, HRAS
13	behavior/neurological phenotype	MP:0005386	7.6	APC, GNAI1, HRAS, PPARG, CREB1, TSHR
14	nervous system phenotype	MP:0003631	7.2	TG, GNAI1, LGALS3, TXNRD2, ADCY8, LGALS1
15	mortality/aging	MP:0010768	6.6	CREB1, PPARG, PTEN, TPO, BRAF, TSHR
16	growth/size phenotype	MP:0005378	6.4	PPARG, TSHR, PIK3CA, TG, PRKAR1A, PRKACA
17	cellular phenotype	MP:0005384	6.3	RET, TXNRD2, GNAS, APC, FLNB, ITGB2
18	cardiovascular system phenotype	MP:0005385	5.6	PIK3CA, ADCY6, ADCY10, CXCL12, PRKAR1A, CREB1
19	homeostasis/metabolism phenotype	MP:0005376	4.8	DIO2, PIK3CA, PPARG, CREB1, CREB3L3, TSHR

Articles related to thyroid adenoma:

(show all 35)

id	Title	Authors	Year	Affiliating Genes
1	The two stem cell microRNA gene clusters C19MC and miR-371-3 are activated by specific chromosomal rearrangements in a subgroup of thyroid adenomas. (20209130)	Rippe V.... Bullerdiek J.	2010	MIR512-1, MIR371A, MIR519A1
2	Prevalence of mutations in TSHR, GNAS, PRKAR1A and RAS genes in a large series of toxic thyroid adenomas from Galicia, an iodine-deficient area in NW Spain. (18694911)	Palos-Paz F.... Victoria B.	2008	GNAS, PRKAR1A, TSHR
3	A domain of the thyroid adenoma associated gene (THADA) conserved in vertebrates becomes destroyed by chromosomal rearrangements observed in thyroid adenomas. (17889454)	Drieschner N.... Nimzyk R.	2007	THADA
4	Markers of cell proliferation, apoptosis, and angiogenesis in thyroid adenomas: a comparative immunohistochemical and genetic investigation of functioning and nonfunctioning nodules. (17381350)	Viacava P.... Naccarato A.G.	2007	HRAS, BCL2, GNAS
5	Protein synthesis inhibitors, in synergy with 5-azacytidine, restore sodium/iodide symporter gene expression in human thyroid adenoma cell line, KAK-1, suggesting trans-active transcriptional repressor. (17164311)	Li W.... Ain K.B.	2007	DNASE1, SLC5A5
6	Toxic thyroid adenoma presenting as hypokalemic periodic paralysis. (17917308)	Tagami T.... Naruse M.	2007	SCN4A
7	Spindle cell metaplasia arising in thyroid adenoma: characterization of its pathology and differential diagnosis. (16610245)	Shikama Y.... Yagihashi S.	2006	TG
8	Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas. (12955091)	Rippe V.... Bullerdiek J.	2003	THADA
9	A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas. (14610350)	Meiboom M.... Bullerdiek J.	2003	ZNF331
10	Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas. (12208673)	O'Donovan N.... Marti U.	2002	FCGBP
11	Expression of cAMP-responsive element binding protein and inducible cAMP early repressor in hyperfunctioning thyroid adenomas. (12039695)	Peri A.... Chiovato L.	2002	TSHR, FHL5, CREB3L3
12	Non-autoimmune hyperthyroidism and hyperfunctioning thyroid adenomas caused by activating mutation of the thyrotropin receptor (11857916)	Kosugi S.	2002	TSHR
13	Molecular cytogenetic investigations define a subgroup of thyroid adenomas with 2p21 breakpoints clustered to a region of less than 450 kb. (12063398)	Bol S.... Bullerdiek J.	2001	THADA
14	Reduced expression of stromal-derived factor 1 in autonomous thyroid adenomas and its regulation in thyroid-derived cells. (11443213)	Aust G.... Simchen C.	2001	ITGB2, TPO, CXCL12
15	The 3',5'-cyclic adenosine monophosphate response element binding protein (CREB) is functionally reduced in human toxic thyroid adenomas. (10650954)	Brunetti A.... Russo D.	2000	GNAS, CREB1
16	Induction of specific phosphodiesterase isoforms by constitutive activation of the cAMP pathway in autonomous thyroid adenomas. (10946896)	Persani L.... Conti M.	2000	GNAS, PDE4A, TSHR
17	Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms. (10566665)	Tonacchera M.... Chiovato L.	1999	TSHR
18	Mutations in the thyrotropin receptor gene in the pathogenesis of toxic thyroid adenomas, toxic goiter nodules and autosomal dominant hyperthyroidism (10355046)	Derwahl M.	1999	GNAS
19	Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours. (10526256)	Esapa C.T.... Harris P.E.	1999	PRKACA, GNAS
20	Thyrotropin receptor mutations in hyperfunctioning thyroid adenomas from Brazil. (10595453)	Nogueira C.R.... Medeiros-Neto G.	1999	GNAS, TSHR
21	Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways. (10534767)	Yeh J.J.... Eng C.	1999	PTEN
22	Gs alpha mutations in hyperfunctioning thyroid adenomas. (10714366)	Murakami M.... Mori M.	1999	TSHR
23	Pathogenesis of toxic thyroid adenomas and nodules: relevance of activating mutations in the TSH-receptor and Gs-alpha gene, the possible role of iodine deficiency and secondary and TSH-independent molecular mechanisms. (9867188)	Derwahl M.... Broecker M.	1998	GNAS
24	Immunohistochemical analysis of thyroid adenomas with Hurthle cells. (9534199)	Kanthan R.... Radhi J.M.	1998	BCL2, MUC1, TG
25	Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas. (9253356)	Parma J.... Vassart G.	1997	TSHR
26	Thyrotropin receptor mutations in hyperfunctioning thyroid adenomas: new mutants, new second messenger and new frequency. (8590945)	Bertherat J.	1996	TSHR
27	Low incidence of the stimulatory G protein alpha-subunit mutations in autonomously functioning thyroid adenomas in Japan. (8837326)	Tanaka K.... Nagataki S.	1996	GNAS
28	TSH receptor and Gs-alpha gene mutations in the pathogenesis of toxic thyroid adenomas--a note of caution. (8768829)	Derwahl M.	1996	GNAS, TSHR
29	Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas. (8626855)	Derwahl M.... Filetti S.	1996	TSHR, ADCY10
30	Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades. (8592518)	Parma J.... Vassart G.	1995	TSHR
31	Expression of functional stimulatory guanine nucleotide binding protein in nonfunctioning thyroid adenomas is not correlated to adenylate cyclase activity and growth of these tumors. (7745026)	Hamacher C.... Derwahl M.	1995	ADCY10
32	Dissociation of thyrotropin-dependent enzyme activities, reduced iodide transport, and preserved iodide organification in nonfunctioning thyroid adenoma and multinodular goiter. (8027249)	Masini-Repiso A.M.... Coleoni A.H.	1994	TPO
33	Direct effect of protirelin (TRH) on PB[123I] in autonomous thyroid adenoma. (7524634)	Kallee E.... Wahl R.	1993	TRH
34	Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. (8413627)	Parma J.... Vassart G.	1993	GNAS, TSHR
35	Bone turnover in overt and subclinical hyperthyroidism due to autonomous thyroid adenoma. (1292974)	De Menis E.... Conte N.	1992	BGLAP

Genes related to thyroid adenoma according to GeneCards:

(show top 50)    (show all 61)

id	Symbol	Description	Score	GeneCards Section Context
1	THADA	thyroid adenoma associated	11.1	Proteins, Publications, Aliases & Descriptions, Transcripts (show all 5 sections) Orthologs
2	DIO2	deiodinase, iodothyronine, type II	11.1	Summaries
3	ADCY6	adenylate cyclase 6	11.1	Summaries
4	ADCY4	adenylate cyclase 4	11.1	Summaries
5	ADCY3	adenylate cyclase 3	11.1	Summaries
6	ADCY7	adenylate cyclase 7	11.1	Summaries
7	ADCY5	adenylate cyclase 5	11.1	Summaries
8	ADCY2	adenylate cyclase 2 (brain)	11.1	Summaries
9	ADCY1	adenylate cyclase 1 (brain)	11.1	Summaries
10	ADCY9	adenylate cyclase 9	11.1	Summaries
11	ADCY8	adenylate cyclase 8 (brain)	11.1	Summaries
12	ZNF331	zinc finger protein 331	11.0	Publications, Aliases & Descriptions
13	PAX8	paired box 8	11.0	Summaries
14	TSHR	thyroid stimulating hormone receptor	11.0	Publications
15	CNC	Carney complex, multiple neoplasia and lentiginosis	11.0
16	GNAS	GNAS complex locus	11.0	Publications
17	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	11.0
18	PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha	11.0	Publications
19	TXNRD2	thioredoxin reductase 2	11.0
20	IFI27	interferon, alpha-inducible protein 27	11.0
21	LGALS1	lectin, galactoside-binding, soluble, 1	11.0
22	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
23	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0
24	GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	11.0
25	TPO	thyroid peroxidase	11.0	Publications
26	GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	11.0
27	RET	ret proto-oncogene	11.0
28	RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	11.0
29	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	11.0
30	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0
31	TG	thyroglobulin	11.0	Publications
32	APC	adenomatous polyposis coli	11.0
33	SHBG	sex hormone-binding globulin	11.0
34	PTEN	phosphatase and tensin homolog	11.0	Publications
35	PPARG	peroxisome proliferator-activated receptor gamma	11.0
36	MIR371A	microRNA 371a	10.9	Publications
37	MIR512-1	microRNA 512-1	10.9	Publications
38	MIR517A	microRNA 517a	10.9	Publications
39	MIR519A1	microRNA 519a-1	10.9	Publications
40	CREB3L3	cAMP responsive element binding protein 3-like 3	10.9	Publications
41	SLC5A5	solute carrier family 5 (sodium iodide symporter), member 5	10.9	Publications
42	SCN4A	sodium channel, voltage-gated, type IV, alpha subunit	10.9	Publications
43	ZNF708	zinc finger protein 708	10.9	Disorders
44	FHL5	four and a half LIM domains 5	10.9	Publications
45	ZNF131	zinc finger protein 131	10.9	Disorders
46	ZNF138	zinc finger protein 138	10.9	Disorders
47	FCGBP	Fc fragment of IgG binding protein	10.9	Publications
48	DNASE1	deoxyribonuclease I	10.9	Publications
49	TRH	thyrotropin-releasing hormone	10.9	Publications
50	PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	10.9	Publications

Pathways related to thyroid adenoma according to GeneDecks:

(show top 50)    (show all 204)

id	Pathway	Score	Top Affiliating Genes
1	Adenylate cyclase activating pathway38	10.3	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
2	Adenylate cyclase-activating neuropeptides10	10.3	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
3	Regulation of CFTR gating (normal and CF)41	10.0	ADCY9, PRKAR1A, ADCY7, ADCY5, ADCY4, ADCY2
4	Breast Cancer Regulation by Stathmin136	9.9	RAF1, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
5	Neurophysiological process PGE2-induced pain processing10	9.9	ADCY9, GNAS, PRKAR1A, ADCY7, ADCY5, ADCY4
6	Neurophysiological process_PGE2-induced pain processing41	9.9	GNAS, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
7	Gastric acid secretion20	9.9	PRKACA, GNAS, GNAI1, ADCY1, ADCY9, ADCY7
8	Bile secretion20	9.8	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
9	Development_Beta-adrenergic receptors signaling via cAMP41	9.8	PRKACA, PRKAR1A, PPARG, GNAS, ADCY1, ADCY9
10	Glutamatergic synapse20	9.8	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
11	Vascular smooth muscle contraction20	9.8	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
12	Development Beta-adrenergic receptors signaling via cAMP10	9.8	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
13	Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation41	9.8	PRKACA, PRKAR1A, GNB3, GNAS, ADCY1, ADCY3
14	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation10	9.8	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
15	Proton Pump Inhibitor Pathway, Pharmacodynamics34	9.8	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
16	Hedgehog Signaling in Mammals36	9.7	GNB3, GNAI1, PRKAR1A, PRKACA, ADCY9, ADCY7
17	Colorectal Cancer Metastasis36	9.6	ADCY9, APC, BRAF, GNB3, PRKAR1A, ADCY7
18	Progesterone-mediated oocyte maturation20	9.5	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
19	GnRH signaling pathway20	9.5	PRKACA, HRAS, GNAS, RAF1, ADCY1, ADCY3
20	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics34	9.5	ADCY9, GNAI1, PDE4A, GNAS, GNB3, ADCY7
21	Development_Endothelin-1/EDNRA signaling41	9.5	ADCY2, ADCY8, ADCY6, ADCY3, ADCY1, HRAS
22	Development Endothelin-1/EDNRA signaling10	9.5	ADCY5, ADCY4, ADCY2, ADCY8, ADCY6, ADCY3
23	Regulation of CFTR activity (norm and CF)41	9.5	ADCY8, ADCY6, ADCY3, ADCY1, PRKACA, PRKAR1A
24	Gap junction20	9.5	ADCY7, RAF1, GNAI1, GNAS, ADCY5, ADCY4
25	Thrombin Signaling36	9.4	ADCY4, RAF1, ADCY2, ADCY8, ADCY6, ADCY3
26	G-AlphaI Signaling36	9.2	ADCY7, GNAI1, RAF1, BRAF, GNB3, HRAS
27	Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling41	9.2	ADCY3, ADCY1, PRKACA, PRKAR1A, GNAI1, ADCY6
28	Development_Role of Activin A in cell differentiation and proliferation41	9.1	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
29	Development Role of Activin A in cell differentiation and proliferation10	9.1	ADCY6, ADCY3, ADCY1, PRKACA, PRKAR1A, CREB1
30	Sperm Motility36	9.1	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
31	Beta-2 adrenergic-dependent CFTR expression41	9.1	ADCY4, ADCY2, ADCY8, ADCY6, ADCY3, ADCY1
32	Development_Beta-adrenergic receptors regulation of ERK41	8.9	ADCY1, PRKACA, PRKAR1A, HRAS, GNB3, GNAS
33	Signal transduction_cAMP signaling41	8.9	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
34	Development Beta-adrenergic receptors regulation of ERK10	8.9	ADCY9, ADCY7, GNB3, GNAS, GNAI1, RAF1
35	Signaling in Gap Junctions36	8.8	ADCY7, ADCY5, ADCY4, ADCY2, ADCY8, ADCY6
36	Signal transduction cAMP signaling10	8.8	ADCY2, ADCY8, ADCY6, ADCY3, ADCY1, PRKACA
37	Signal transduction_PKA signaling41	8.7	ADCY1, PRKACA, PRKAR1A, CREB1, GNAS, GNAI1
38	Signal transduction PKA signaling10	8.7	ADCY9, ADCY7, ADCY5, ADCY4, PDE4A, GNAI1
39	Chemokine signaling pathway20	8.6	PRKACA, HRAS, GNB3, GNAI1, RAF1, BRAF
40	Melanogenesis20	8.4	ADCY6, ADCY3, ADCY1, PRKACA, CREB3L3, CREB1
41	Relaxin Pathway36	8.4	ADCY6, ADCY3, ADCY1, PRKACA, PRKAR1A, CREB1
42	PKA Signaling36	8.3	PRKACA, PRKAR1A, CREB1, GNB3, GNAI1, SCN4A
43	Activation of cAMP-Dependent PKA36	8.1	ADCY2, SCN4A, RAF1, GNAI1, GNB3, ADCY8
44	GnRH Signaling36	8.1	ADCY1, PRKACA, PRKAR1A, CREB1, HRAS, GNB3
45	Molecular Mechanisms of Cancer36	7.9	ADCY9, HRAS, GNB3, APC, ITGB2, BCL2
46	Cholinergic synapse20	7.8	ADCY8, ADCY6, ADCY3, ADCY1, PRKACA, CREB3L3
47	Activation of PKA through GPCR36	7.7	ADCY9, ADCY7, ADCY5, HRAS, GNB3, GNAI1
48	cAMP Pathway36	7.7	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
49	ERK Signaling36	7.1	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ITGB2
50	MAPK Signaling36	7.0	PRKACA, PRKAR1A, CREB1, HRAS, GNB3, GNAI1

Compounds related to thyroid adenoma according to GeneDecks:

(show top 50)    (show all 154)

id	Compound	Score	Top Affiliating Genes
1	nkh 47742	10.4	ADCY5, ADCY4, ADCY2, ADCY8, ADCY6, ADCY3
2	bpipp42	10.4	ADCY9, ADCY7, ADCY5, ADCY1, ADCY3, ADCY6
3	pacap 1-3842	10.3	ADCY1, ADCY8, ADCY6, ADCY3, ADCY2, ADCY4
4	Pyruvic acid9 18 9	12.3	ADCY7, ADCY9, ADCY1, ADCY3, ADCY6, ADCY8
5	rapamycin32 42	11.1	LGALS1, BRAF, HRAS, RAF1
6	sodium iodide32	10.1	SLC5A5, RET, PAX8, TPO, TSHR, TG
7	iodide32 18	10.9	SERPINA7, BRAF, PAX8, SLC5A5, TPO, DIO2
8	iodine32 18	10.8	SLC5A5, TG, TSHR, DIO2, SERPINA7, BRAF
9	ly29400232	9.7	PIK3CA, RET, ITGB2, IFI27, GNAI1, HRAS
10	threonine32	9.7	SERPINA7, CXCL12, DIO2, GNAS, GNAI1, SCN4A
11	sq 2253632 42	10.6	PDE4A, ADCY1, ADCY10, ADCY3, ADCY6, ADCY8
12	glucose32	9.6	TRH, PDE4A, APC, LGALS1, BRAF, GNAI1
13	triiodothyronine32	9.6	TRH, TPO, TG, DIO2, SHBG, SERPINA7
14	methimazole32 9 9	11.5	SERPINA7, BGLAP, DIO2, TRH, TSHR
15	agar32	9.3	LGALS1, MUC1, RET, RASSF1, BRAF, TG
16	crcs32	9.2	APC, PIK3CA, MUC1, PTEN, HRAS, RASSF1
17	thyroxine32 18	10.0	TG, SERPINA7, PPARG, DIO2, TPO, TRH
18	aspartate32	9.0	DNASE1, TG, SHBG, TXNRD2, TPO, RET
19	lithium32 34 9 18 9	12.5	ADCY1, CREB1, TPO, TRH, GNB3, GNAI1
20	estrogen32	8.4	SERPINA7, RAF1, RASSF1, BGLAP, LGALS3, APC
21	pge232	8.4	GNAS, ADCY10, ADCY1, CREB1, PPARG, GNAI1
22	acth32	8.4	CREB1, SERPINA7, GNAI1, TRH, TPO, ADCY1
23	kt 572032 42	9.3	PDE4A, RAF1, ADCY10, PRKAR1A, PRKACA, CREB1
24	dopamine32 9 18 9	11.1	PIK3CA, PDE4A, RET, RAF1, APC, GNAI1
25	guanine32 9 18 9	11.1	HRAS, GNB3, TXNRD2, CREB1, TSHR, TG
26	alanine32	8.0	PPARG, SHBG, RET, DIO2, SERPINA7, BRAF
27	isoproterenol32 9 9	10.0	GNAS, CREB1, DNASE1, ADCY1, ADCY10, ADCY3
28	magnesium32 9 18 9	10.9	ADCY2, ADCY10, ADCY9, ADCY7, ADCY5, ITGB2
29	ibmx32	7.8	PPARG, PRKACA, ITGB2, PDE4A, CREB1, ADCY1
30	retinoic acid32 42 18	9.6	RAF1, RASSF1, BGLAP, LGALS3, ITGB2, APC
31	paraffin32	7.5	PTEN, TG, TSHR, IFI27, HRAS, APC
32	arginine32	7.5	SCN4A, SERPINA7, ADCY10, ADCY1, RET, PDE4A
33	progesterone32 42 9 18 9	11.4	CXCL12, TSHR, SHBG, PIK3CA, BCL2, PTEN
34	phosphatidylinositol32	7.3	LGALS3, PIK3CA, RET, BRAF, RAF1, BCL2
35	phosphoinositide32	7.2	IFI27, ITGB2, PIK3CA, RAF1, LGALS3, APC
36	wortmannin32 42	8.2	LGALS3, APC, ITGB2, RAF1, BRAF, GNAI1
37	cisplatin32 34 9 9	10.0	BRAF, MUC1, PIK3CA, RAF1, RASSF1, BGLAP
38	testosterone32 9 18 9	10.0	IFI27, TPO, TRH, PIK3CA, APC, MUC1
39	oligonucleotide32	6.9	HRAS, GNAS, IFI27, APC, ITGB2, TRH
40	genistein32 9 18 9	9.9	HRAS, IFI27, ITGB2, RAF1, RET, TPO
41	forskolin32 42 9 9	9.8	PRKAR1A, PRKACA, ADCY1, ADCY10, ADCY3, TSHR
42	cyclic amp32 18	7.7	RET, PDE4A, ADCY9, ADCY7, ADCY5, ADCY4
43	cycloheximide32	6.6	ADCY10, CXCL12, TG, CREB1, PPARG, DIO2
44	adenylate32	6.5	ADCY9, TG, DNASE1, PRKAR1A, CXCL12, ADCY1
45	lipid32	6.2	TXNRD2, TRH, PTEN, PPARG, CREB1, SHBG
46	tyrosine32	6.1	PIK3CA, PDE4A, RET, SERPINA7, BRAF, DIO2
47	vegf32	5.8	CXCL12, PIK3CA, PDE4A, BCL2, RAF1, BRAF
48	dexamethasone32 42 34 9 9	9.2	TRH, GNAI1, PPARG, CREB1, DNASE1, PRKAR1A
49	calcium32 9 18 9	8.2	CREB1, DIO2, PTEN, TPO, TRH, TXNRD2
50	serine32	5.1	HRAS, LGALS1, PAX8, BRAF, BGLAP, RASSF1

Cellular components related to thyroid adenoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	5.9	ADCY9, TPO, TRH, HRAS, GNB3, GNAS
2	nucleus	GO:005634	4.9	ADCY1, LGALS1, BCL2, PAX8, RASSF1, RAF1

Biological processes related to thyroid adenoma according to GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone biosynthetic process	GO:042446	10.3	TG, TPO, DIO2
2	adenylate cyclase-activating G-protein coupled receptor signaling pathway	GO:007189	10.2	ADCY9, ADCY4, ADCY5, ADCY7, TSHR, ADCY8
3	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	GO:007193	10.2	ADCY5, ADCY4, ADCY2, ADCY8, ADCY6, ADCY3
4	thyroid hormone generation	GO:006590	10.1	SLC5A5, TPO, DIO2
5	cAMP biosynthetic process	GO:006171	9.9	ADCY6, GNAS, ADCY1, ADCY2, ADCY4, ADCY10
6	activation of protein kinase A activity	GO:034199	9.9	ADCY5, PRKAR1A, ADCY7, ADCY4, ADCY2, ADCY8
7	water transport	GO:006833	9.8	ADCY6, ADCY9, ADCY7, ADCY3, ADCY1, PRKACA
8	cellular response to glucagon stimulus	GO:071377	9.7	GNAS, GNB3, PRKAR1A, ADCY5, ADCY4, ADCY2
9	energy reserve metabolic process	GO:006112	9.7	ADCY2, ADCY8, ADCY9, ADCY6, ADCY3, ADCY1
10	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.7	BRAF, RAF1, BCL2, PIK3CA
11	response to peptide hormone stimulus	GO:043434	9.7	SERPINA7, BRAF, GNAI1, CXCL12
12	response to corticosterone stimulus	GO:051412	9.6	TRH, SERPINA7, BCL2
13	intracellular signal transduction	GO:035556	9.6	ADCY7, ADCY9, ADCY4, ADCY8, ADCY6, ADCY3
14	transmembrane transport	GO:055085	9.5	ADCY8, ADCY4, ADCY5, ADCY6, ADCY3, SLC5A5
15	activation of phospholipase C activity	GO:007202	9.1	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
16	small molecule metabolic process	GO:044281	9.0	PIK3CA, GNAS, GNB3, TPO, PTEN, DIO2
17	blood coagulation	GO:007596	8.7	ITGB2, GNAI1, RAF1, PIK3CA, GNAS, PRKACA
18	synaptic transmission	GO:007268	8.6	GNB3, ADCY7, ADCY8, ADCY4, ADCY9, ADCY5
19	epidermal growth factor receptor signaling pathway	GO:007173	8.3	PIK3CA, RAF1, ADCY6, ADCY5, HRAS, PTEN
20	fibroblast growth factor receptor signaling pathway	GO:008543	8.3	PTEN, HRAS, RAF1, BRAF, PIK3CA, CREB1
21	nerve growth factor receptor signaling pathway	GO:048011	8.2	ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
22	response to drug	GO:042493	7.9	SERPINA7, BGLAP, PDE4A, LGALS1, APC, PPARG
23	signal transduction	GO:007165	6.8	TG, CREB1, RAF1, TRH, LGALS1, FLNB

Molecular functions related to thyroid adenoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	thyroid-stimulating hormone receptor activity	GO:004996	10.3	TSHR, PAX8
2	calcium- and calmodulin-responsive adenylate cyclase activity	GO:008294	10.2	ADCY8, ADCY2, ADCY5, ADCY6, ADCY1
3	adenylate cyclase activity	GO:004016	9.6	GNAS, ADCY9, ADCY7, ADCY4, ADCY2, ADCY8
4	metal ion binding	GO:046872	9.2	ADCY6, ADCY9, ADCY7, ADCY5, PDE4A, RAF1
5	ATP binding	GO:005524	8.4	ADCY9, PIK3CA, RET, BRAF, ADCY4, RAF1