MCID: THY035
MIFTS: 32

Thyroid Adenoma malady

Endocrine diseases category

Summaries for Thyroid Adenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A thyroid adenoma is a benign tumor of the thyroid gland. more...

MalaCards: Thyroid Adenoma, also known as thyroid gland follicular adenoma, is related to thyroiditis and adenoma. An important gene associated with Thyroid Adenoma is THADA (thyroid adenoma associated), and among its related pathways are G-Beta Gamma Signaling and Calcium signaling pathway. The compounds 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE and 125i have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Thyroid Adenoma

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10DISEASES, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

thyroid adenoma 10 44
thyroid gland follicular adenoma 60


Related Diseases for Thyroid Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Thyroid Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.6SERPINA7, TSHR
2adenoma31.6CNC, ADCY1, TSHR, PAX8, LGALS3, PRKAR1A
3follicular adenoma30.9TSHR, LGALS3, PAX8, DIO2, GNAS
4graves' disease30.6TSHR, GNAS
5follicular thyroid carcinoma30.6LGALS3, TSHR, PAX8, DIO2
6hyperthyroidism30.6GNAS, DIO2, SERPINA7, TSHR
7goiter30.5SERPINA7, GNAS, TSHR, LGALS3, PAX8, DIO2
8papillary carcinoma30.4GNAS, PAX8, LGALS3, TSHR
9papillary thyroid carcinoma30.4LGALS3, PAX8, TSHR
10thyroid cancer30.4LGALS3, PAX8, PRKAR1A, GNAS, TSHR
11autoimmune thyroiditis30.3SERPINA7, LGALS3, TSHR
12thyrotoxicosis30.1SERPINA7, TSHR
13parathyroid adenoma30.1PRKAR1A, GNAS, LGALS3
14pituitary adenoma30.1LGALS3, SERPINA7, GNAS, PRKAR1A, CNC
15congenital hypothyroidism29.9SERPINA7, PAX8, TSHR, GNAS
16hypothyroidism29.9TSHR, SERPINA7, PAX8, DIO2, GNAS
17wermer syndrome29.9PRKAR1A
18acromegaly29.9GNAS, CNC, PRKAR1A
19papillary adenoma10.3
20hyperparathyroidism10.3
21multinodular goiter10.3
22primary hyperparathyroidism10.2
23osteoporosis10.1
24cervicitis10.1
25laryngitis10.1
26thyroid adenoma, hyperfunctioning, somatic10.1
27colorectal cancer10.0LGALS3
28breast cancer10.0PRKAR1A, LGALS3
29diabetes mellitus10.0GNB3
30mccune albright syndrome10.0GNAS, PRKAR1A, ADCY2
31pseudohypoparathyroidism10.0ADCY2, GNAS
32carney complex10.0PRKAR1A, GNAS
33endemic goiter10.0TSHR
34obesity10.0GNB3, DIO2, GNAS
35adrenal adenoma10.0PRKAR1A, CNC, GNAS
36thyroid agenesis10.0PAX8, TSHR, SERPINA7, LGALS3
37thyroid cancer, anaplastic10.0TSHR, LGALS3, PAX8
38insulin resistance10.0GNAS, GNB3, DIO2
39acrodysostosis10.0PRKAR1A, GNAS
40cushing's syndrome10.0GNAS, CNC, PRKAR1A
41euthyroid sick syndrome10.0SERPINA7
42ovarian cyst10.0CNC, GNAS
43hyperthyroxinemia10.0TSHR, SERPINA7
44pituitary tumors10.0PRKAR1A, CNC, LGALS3, GNAS
45pendred syndrome10.0PAX8
46nodular goiter10.0TSHR, LGALS3
47cholera10.0ADCY8, ADCY3, ADCY6, ADCY2, ADCY1, ADCY4
48adrenal gland hyperfunction10.0PRKAR1A, CNC
49nontoxic goiter10.0
50acute thyroiditis10.0

Graphical network of the top 20 diseases related to Thyroid Adenoma:



Diseases related to thyroid adenoma

Clinical Features for Thyroid Adenoma

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Drugs & Therapeutics for Thyroid Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Thyroid Adenoma

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Anatomical Context for Thyroid Adenoma

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32MalaCards
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MalaCards organs/tissues related to Thyroid Adenoma:

32
Thyroid

Animal Models for Thyroid Adenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thyroid Adenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9ADCY8, DIO2, PRKAR1A, PAX8, LGALS3, TSHR

Publications for Thyroid Adenoma

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Genetic Variations for Thyroid Adenoma

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Expression for genes affiliated with Thyroid Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroid Adenoma

Search GEO for disease gene expression data for Thyroid Adenoma.

Pathways for genes affiliated with Thyroid Adenoma

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 12EMD Millipore
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Pathways related to Thyroid Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0ADCY9, ADCY2, ADCY6, ADCY7, PRKAR1A, ADCY3
29.9ADCY8, ADCY1, ADCY9, ADCY2, ADCY7, ADCY4
3
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9.9ADCY3, ADCY7, GNAS, ADCY6, ADCY2, ADCY8
49.9ADCY8, ADCY9, ADCY4, ADCY3, ADCY7, ADCY2
59.9ADCY2, ADCY9, ADCY5, ADCY1, ADCY8, ADCY4
6
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9.9ADCY9, ADCY7, ADCY2, ADCY6, ADCY3, ADCY1
79.9ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
8
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9.9ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
99.9ADCY7, ADCY3, ADCY6, ADCY8, ADCY5, ADCY4
10
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9.8GNAS, GNB3, ADCY6, ADCY2, ADCY9, ADCY5
11
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9.8ADCY1, ADCY5, ADCY9, ADCY2, ADCY6, ADCY3
12
Hide members
9.8TSHR, ADCY7, ADCY3, ADCY4, ADCY8, ADCY1
13
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9.8GNAS, ADCY7, ADCY3, ADCY6, ADCY2, ADCY9
149.8ADCY3, ADCY7, GNAS, ADCY6, ADCY2, ADCY4
159.8ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
16
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9.8GNAS, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
17
Development Endothelin-1/EDNRA signaling
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9.8ADCY9, ADCY5, ADCY1, ADCY8, ADCY4, ADCY2
189.8ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
199.8ADCY3, ADCY7, GNAS, ADCY4, ADCY8, ADCY1
209.8ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
219.8ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
22
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9.8ADCY1, ADCY5, ADCY9, ADCY2, ADCY6, ADCY3
23
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9.8ADCY6, ADCY5, ADCY4, ADCY8, ADCY1, ADCY9
249.8ADCY2, ADCY6, ADCY8, ADCY1, ADCY5, ADCY9
25
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9.8PRKAR1A, ADCY7, ADCY3, ADCY6, ADCY2, ADCY9
26
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9.8LGALS3, ADCY7, ADCY3, ADCY6, ADCY2, ADCY9
27
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9.8ADCY6, ADCY2, ADCY5, ADCY3, ADCY4, ADCY8
28
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9.8ADCY4, GNB3, ADCY7, ADCY3, ADCY6, ADCY2
29
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9.8ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
30
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9.8ADCY3, ADCY4, ADCY8, ADCY5, ADCY2, ADCY6
31
Hide members
9.8ADCY8, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
32
Hide members
9.8ADCY8, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
33
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9.8ADCY8, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
34
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
9.8ADCY9, ADCY2, ADCY6, ADCY3, ADCY7, PRKAR1A
359.8GNAS, PRKAR1A, ADCY7, ADCY3, ADCY6, ADCY2
36
Hide members
9.8ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
37
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9.8ADCY5, ADCY4, ADCY1, GNB3, ADCY3, ADCY6
38
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9.8GNB3, PRKAR1A, ADCY7, ADCY3, ADCY6, ADCY2
39
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9.8GNB3, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
409.8ADCY2, ADCY5, ADCY1, ADCY8, ADCY4, ADCY9
419.8ADCY2, ADCY6, ADCY3, ADCY7, PRKAR1A, GNB3
42
Hide members
9.8GNB3, ADCY3, ADCY8, ADCY6, ADCY2, ADCY9
43
Hide members
9.8ADCY8, ADCY3, PRKAR1A, ADCY6, ADCY2, ADCY9
44
Hide members
9.8ADCY2, ADCY1, ADCY3, ADCY7, PRKAR1A, ADCY9
45
Hide members
9.8ADCY4, ADCY7, ADCY3, ADCY6, PRKAR1A, ADCY2
46
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9.7GNAS, GNB3, ADCY4, ADCY8, ADCY1, ADCY5
47
Signal transduction cAMP signaling
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9.7ADCY4, ADCY8, GNAS, GNB3, PRKAR1A, ADCY5
48
Hide members
9.7ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
49
Hide members
9.7PRKAR1A, GNB3, GNAS, ADCY7, ADCY3, ADCY4
50
G-protein signaling G-Protein alpha-i signaling cascades
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9.7ADCY6, ADCY3, ADCY7, PRKAR1A, GNB3, GNAS

Compounds for genes affiliated with Thyroid Adenoma

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Sources:
11DrugBank, 44Novoseek, 24HMDB, 2BitterDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Thyroid Adenoma according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
12',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE1110.6GNAS, ADCY2, ADCY5
2125i4410.6DIO2, SERPINA7, TSHR
3iodide44 2411.6TSHR, SERPINA7, PAX8, DIO2
4iodine44 2411.6GNAS, DIO2, SERPINA7, TSHR
5methimazole44 2 1112.5TSHR, SERPINA7, DIO2
6thyroxine44 2411.5DIO2, PAX8, SERPINA7, TSHR
7sialic acid4410.5TSHR, SERPINA7, LGALS3, GNAS
8ribonucleic acid4410.5TSHR, SERPINA7, PAX8, DIO2, GNAS
9triiodothyronine4410.5TSHR, SERPINA7, DIO2
10acth4410.4GNAS, LGALS3, SERPINA7, TSHR, ADCY1
11isoproterenol44 1111.4GNAS, ADCY7, ADCY3, ADCY2, ADCY1
12glucose4410.4TSHR, SERPINA7, DIO2
13sodium iodide4410.4TSHR, PAX8
14Liothyronine11 2411.4SERPINA7, DIO2
15dopamine44 28 11 2413.3GNAS, GNB3, DIO2, SERPINA7, ADCY6, ADCY2
16Pyruvic acid11 2411.3ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
17threonine4410.3GNAS, DIO2, PAX8, LGALS3, SERPINA7, TSHR
18pacap 1-275910.3ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
19kh 75910.3ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
20mdl 12330a hydrochloride5910.3ADCY4, ADCY8, ADCY1, ADCY7, ADCY3, ADCY6
21nkh 4775910.3ADCY8, ADCY4, ADCY1, ADCY5, ADCY9, ADCY2
22sq 2253659 4411.3ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
23arginine4410.3GNAS, PRKAR1A, LGALS3, SERPINA7, TSHR, ADCY1
24nad28 2411.3ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
25phosphoric acid44 2411.3ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
26pyrophosphate44 2411.3ADCY8, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
27adenylate4410.3GNAS, PRKAR1A, TSHR, ADCY3, ADCY6, ADCY2
28nadh44 11 2412.3ADCY7, ADCY4, ADCY8, ADCY1, ADCY5, ADCY9
29progesterone44 59 28 11 2414.3GNAS, LGALS3, SERPINA7, TSHR, ADCY1
30Adenosine triphosphate11 2411.2ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
31asparagine4410.2GNAS, SERPINA7, TSHR
32magnesium44 11 2412.2PRKAR1A, ADCY7, ADCY3, ADCY6, ADCY2, ADCY9
33forskolin44 49 1112.2GNAS, DIO2, PRKAR1A, PAX8, TSHR, ADCY7
34propylthiouracil44 2 1112.1TSHR, DIO2
35cyclic amp44 2411.0GNAS, PRKAR1A, CNC, TSHR, ADCY7, ADCY3
36calcium44 49 11 2412.9ADCY7, TSHR, LGALS3, PRKAR1A, DIO2, GNAS

GO Terms for genes affiliated with Thyroid Adenoma

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16Gene Ontology
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Cellular components related to Thyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:01602010.1ADCY4, ADCY8, ADCY2, ADCY6, DIO2, GNAS
2plasma membraneGO:0058869.2ADCY4, GNAS, GNB3, DIO2, PRKAR1A, LGALS3

Biological processes related to Thyroid Adenoma according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.4ADCY5, GNAS
2cellular response to catecholamine stimulusGO:07187010.3GNAS, ADCY6
3cAMP biosynthetic processGO:00617110.2GNAS, ADCY6, ADCY2, ADCY1, ADCY4
4adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.2ADCY7, ADCY3, ADCY6, ADCY2, ADCY4, ADCY8
5adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.2ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
6activation of phospholipase C activityGO:00720210.2ADCY1, ADCY5, ADCY9, ADCY2, ADCY6, ADCY3
7fibroblast growth factor receptor signaling pathwayGO:00854310.2ADCY2, ADCY6, ADCY3, ADCY7, PRKAR1A, ADCY9
8activation of protein kinase A activityGO:03419910.1ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
9epidermal growth factor receptor signaling pathwayGO:00717310.1ADCY8, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
10cellular response to prostaglandin E stimulusGO:07138010.1ADCY6, GNAS
11intracellular signal transductionGO:03555610.1ADCY6, ADCY3, ADCY7, PRKAR1A, ADCY2, ADCY9
12neurotrophin TRK receptor signaling pathwayGO:04801110.0ADCY6, ADCY3, ADCY7, PRKAR1A, ADCY2, ADCY9
13water transportGO:00683310.0GNAS, ADCY4, ADCY8, ADCY1, ADCY5, ADCY9
14synaptic transmissionGO:00726810.0ADCY6, ADCY3, ADCY7, GNB3, ADCY2, ADCY9
15energy reserve metabolic processGO:00611210.0ADCY4, GNAS, GNB3, ADCY8, ADCY1, ADCY5
16cellular response to glucagon stimulusGO:07137710.0ADCY8, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
17transmembrane transportGO:05508510.0ADCY3, ADCY7, PRKAR1A, GNAS, ADCY6, ADCY2
18innate immune responseGO:0450879.9ADCY3, ADCY7, LGALS3, PRKAR1A, ADCY6, ADCY2
19signal transductionGO:0071659.8PRKAR1A, ADCY7, ADCY3, ADCY6, ADCY2, ADCY9
20small molecule metabolic processGO:0442819.7GNAS, GNB3, DIO2, PRKAR1A, ADCY7, ADCY3

Molecular functions related to Thyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase bindingGO:00817910.3ADCY5, ADCY2
2calcium- and calmodulin-responsive adenylate cyclase activityGO:00829410.3ADCY2, ADCY1, ADCY8
3thyroid-stimulating hormone receptor activityGO:00499610.1TSHR, PAX8
4adenylate cyclase activityGO:00401610.0ADCY4, GNAS, ADCY7, ADCY3, ADCY6, ADCY2
5metal ion bindingGO:0468729.8GNAS, ADCY7, ADCY3, ADCY6, ADCY2, ADCY9
6ATP bindingGO:0055249.8ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5

Products for genes affiliated with Thyroid Adenoma

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  • Antibodies
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Sources for Thyroid Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet