MCID: THY028
MIFTS: 74

Thyroid Cancer malady

Cancer diseases, Endocrine diseases categories

Summaries for Thyroid Cancer

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MedlinePlus:34 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it makes hormones that help the body work normally. there are several types of cancer of the thyroid gland. you are at greater risk if you are between ages 25 and 65 are a woman are asian have a family member who has had thyroid disease have had radiation treatments to your head or neck you should see a doctor if you have a lump or swelling in your neck. doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose thyroid cancer. treatment depends on the type of cancer you have and how far the cancer has spread. many patients receive a combination of treatments. they may include surgery, radioactive iodine, hormone treatment, radiation therapy, chemotherapy, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards based summary: Thyroid Cancer, also known as thyroid carcinoma, is related to thyroiditis and goiter. An important gene associated with Thyroid Cancer is NKX2-1 (NK2 homeobox 1), and among its related pathways are EGFR Transactivation by Gastrin and SHC1 events in ERBB2 signaling. The drugs interferon alfa-2b and thyroglobulin and the compounds panitumumab and phenylacetate have been mentioned in the context of this disorder. Affiliated tissues include the thryoid gl, thyroid and testes, and related mouse phenotypes are muscle and adipose tissue.

Disease Ontology:10 An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.

Wikipedia:65 Thyroid cancer is a cancer originating from follicular or parafollicular thyroid cells. more...

Aliases & Classifications for Thyroid Cancer

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Thyroid Cancer, Aliases & Descriptions:

Name: Thyroid Cancer 10 12 45 34
Thyroid Carcinoma 10 45 62
Malignant Neoplasm of Thyroid Gland 10 62
Neoplasm of Thyroid Gland 10 62
Thyroid Gland Neoplasm 10 62
 
Thyroid Neoplasm 10 62
Malignant Tumour of Thyroid Gland 10
Head and Neck Cancer, Thyroid 10
Malignant Neoplasm of Thyroid 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology10 DOID:1781, DOID:3963
NCIt40 C7510, C4815
ICD9CM29 193
MeSH35 D013964
ICD1027 C73

Related Diseases for Thyroid Cancer

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Diseases related to Thyroid Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 313)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis32.4TG, TSHR, CALCA
2goiter31.1NKX2-1, CALCA, RET, TSHR, PAX8, BRAF
3graves' disease30.8TSHR, PAX8, TG, NKX2-1
4multiple endocrine neoplasia30.8CALCA, RET, TG
5thyroid carcinoma, follicular30.8PTEN, HRAS, NRAS
6struma ovarii30.7TSHR, TG, NKX2-1
7multinodular goiter30.7TSHR, CALCA, TG
8nodular goiter30.7CALCA, RET, TSHR, BRAF, TG, HRAS
9thyroid carcinoma, papillary30.6EGF, CDKN1A, KISS1R, RASSF1, RET, TSHR
10endemic goiter30.6TG, TSHR
11thyrotoxicosis30.5TG, TSHR
12hypothyroidism30.5NKX2-1, TSHR, TG
13pituitary adenoma30.5PTTG1, RET, PPARG
14retinoblastoma30.4HRAS, PPARG, PIK3CA, RASSF1, CDKN1A, EGF
15adenocarcinoma30.4CDKN1A, HRAS, BRAF, PTEN, RASSF1, PTTG1
16autoimmune thyroiditis30.4TG, CALCA
17medullary thyroid carcinoma, familial30.4CALCA, RET
18paraganglioma30.4CALCA, RET, TG
19adenoma30.4TG, BRAF, PAX8, TSHR, RET, CALCA
20melanoma30.4TSHR, PIK3CA, PTEN, CDKN1A, BRAF, NKX2-1
21leukemia30.3PIK3CA, CDKN1A, PTTG1, TSHR, NRAS, EGF
22papillary carcinoma30.3HRAS, NKX2-1, CALCA, RET, TSHR, PAX8
23hashimoto thyroiditis30.3RET, TSHR, BRAF, TG, CALCA
24neuroendocrine tumor30.3NKX2-1, RASSF1, RET, PAX8, CALCA
25subacute thyroiditis30.2TSHR, TG
26neuroma30.2RET, CALCA
27thyroid cancer, anaplastic30.1RET, TSHR, PAX8, BRAF, CALCA, NKX2-1
28breast cancer30.1EGF, CDKN1A, RASSF1, NKX2-1, PTEN, PIK3CA
29thyroid adenoma30.1PPARG, PIK3CA, PTEN, TG, BRAF, TSHR
30myxedema30.0TG, TSHR
31adenomatous polyposis coli30.0BRAF, RASSF1, NRAS, PPARG
32nontoxic goiter30.0TG, TSHR
33cowden disease30.0PTEN, RET, PIK3CA
34islet cell tumor30.0CALCA, RET
35glioblastoma multiforme29.9EGF, PIK3CA, CDKN1A, PTEN
36brain cancer29.9PTEN, EGF, CDKN1A, PIK3CA
37astrocytoma29.9PTTG1, PIK3CA, EGF, PTEN, HRAS, CDKN1A
38glioblastoma29.9PPARG, EGF, HRAS, CDKN1A, RASSF1, PTEN
39hepatocellular carcinoma29.9KISS1R, CDKN1A, RASSF1, HRAS, NKX2-1, PTEN
40follicular adenoma29.8HRAS, TG, PTEN, PPARG, NKX2-1, CALCA
41cervicitis10.6
42endotheliitis10.5
43thyroid carcinoma, hurthle cell10.5
44familial papillary thyroid carcinoma10.4
45hyperthyroidism10.4
46pheochromocytoma10.4
47hyperparathyroidism10.4
48mediastinitis10.3
49carcinoma showing thymus-like differentiation10.3
50nonmedullary thyroid carcinoma, with or without cell oxyphilia10.3

Graphical network of the top 20 diseases related to Thyroid Cancer:



Diseases related to thyroid cancer

Symptoms for Thyroid Cancer

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Drugs & Therapeutics for Thyroid Cancer

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Genetic Tests for Thyroid Cancer

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Anatomical Context for Thyroid Cancer

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MalaCards organs/tissues related to Thyroid Cancer:

33
Thyroid, Testes, Lymph node, Endothelial, Bone, Lung, Pituitary, Breast, T cells, Liver, Salivary gland, Skin, Ovary, Myeloid, Thymus, Brain, Colon, Prostate, Testis, Cervix, Nk cells

FMA organs/tissues related to Thyroid Cancer:

16
The thryoid gl

Animal Models for Thyroid Cancer or affiliated genes

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MGI Mouse Phenotypes related to Thyroid Cancer:

37 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1CDKN1A, RET, BRAF, PTEN, PIK3CA, PPARG
2MP:00053759.1PPARG, PIK3CA, PTTG1, PTEN, BRAF, CDKN1A
3MP:00053889.0PTEN, BRAF, RET, CALCA, NKX2-1, CDKN1A
4MP:00053708.9PPARG, PTEN, BRAF, NRAS, KISS1R, CDKN1A
5MP:00053918.9PPARG, PIK3CA, PTEN, BRAF, NRAS, CDKN1A
6MP:00053818.9PTEN, BRAF, RET, NKX2-1, NRAS, KISS1R
7MP:00053778.9PPARG, PAX8, TSHR, CALCA, CDKN1A
8MP:00053908.7PPARG, PTEN, BRAF, PAX8, CALCA, NKX2-1
9MP:00030128.7PPARG, PIK3CA, PTTG1, PAX8, RET, NKX2-1
10MP:00107718.5PPARG, PIK3CA, PTEN, BRAF, CALCA, NRAS
11MP:00020068.4PPARG, PIK3CA, PTEN, BRAF, RET, CALCA
12MP:00028738.4PPARG, PTEN, BRAF, RET, CALCA, NRAS
13MP:00053978.3PPARG, PTTG1, PTEN, TG, BRAF, TSHR
14MP:00053808.2PTEN, PTTG1, PIK3CA, PPARG, BRAF, PAX8
15MP:00053678.2PPARG, PTTG1, PTEN, BRAF, PAX8, RET
16MP:00053858.1PAX8, BRAF, PTEN, PIK3CA, PPARG, RET
17MP:00053848.1PTEN, PTTG1, PIK3CA, PPARG, BRAF, PAX8
18MP:00053868.0BRAF, PTEN, PTTG1, PIK3CA, PPARG, TSHR
19MP:00053877.9BRAF, PTEN, PTTG1, PIK3CA, PPARG, TSHR
20MP:00053897.9PPARG, PIK3CA, PTTG1, PTEN, BRAF, PAX8
21MP:00053797.6HRAS, PPARG, PIK3CA, PTTG1, PTEN, TG
22MP:00036317.5BRAF, TG, PTEN, PTTG1, PIK3CA, PPARG
23MP:00053787.4BRAF, TG, PTEN, PTTG1, PIK3CA, PPARG
24MP:00107687.2PAX8, BRAF, PTEN, PTTG1, PIK3CA, PPARG
25MP:00053767.1PAX8, BRAF, TG, PTEN, PTTG1, PIK3CA

Publications for Thyroid Cancer

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Articles related to Thyroid Cancer:

(show top 50)    (show all 1661)
idTitleAuthorsYear
1
Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations. (25855579)
2015
2
Association of the miR-149 Rs2292832 Polymorphism with Papillary Thyroid Cancer Risk and Clinicopathologic Characteristics in a Chinese Population. (25405731)
2014
3
Commentary on: Implications of thyroglobulin antibody positivity in patients with differentiated thyroid cancer: a clinical position statement. (23987661)
2013
4
Evolving approaches to patients with advanced differentiated thyroid cancer. (23575762)
2013
5
Synoptic pathology reporting for thyroid cancer: a review and institutional experience. (24053206)
2013
6
Vandetanib: a novel targeted therapy for the treatment of metastatic or locally advanced medullary thyroid cancer. (23640345)
2013
7
High-Risk Patients with Differentiated Thyroid Cancer T4 Primary Tumors Achieve Remnant Ablation Equally Well Using rhTSH or Thyroid Hormone Withdrawal. (24040896)
2013
8
Differentiated thyroid cancer: indications and extent of central neck dissection--our experience. (24282633)
2013
9
Severe Hyponatremia Following Radioactive Iodine Therapy in Patients with Differentiated Thyroid Cancer. (24093878)
2013
10
Immunohistochemical detection of mutated BRAF V600E supports the clonal origin of BRAF-induced thyroid cancers along the spectrum of disease progression. (23775351)
2013
11
The current status of lymph node dissection in the treatment of papillary thyroid cancer. A literature review. (24045534)
2013
12
MK-2206 causes growth suppression and reduces neuroendocrine tumor marker production in medullary thyroid cancer through Akt inhibition. (23900743)
2013
13
Clinical behavior and genetics of nonsyndromic, familial nonmedullary thyroid cancer. (23652675)
2013
14
Marginal treatment benefit in anaplastic thyroid cancer. (23839797)
2013
15
Accidental discovery of lung metastases from differentiated thyroid cancer by 99mTc sodium pertechnetate scan in a patient with secondary hyperparathyroidism. (22889782)
2012
16
Incidental detection of hyperfunctioning thyroid cancer metastases in patients presenting with thyrotoxicosis. (22837931)
2012
17
BRAF(V600E) mutation in Turkish patients with papillary thyroid cancer: strong correlation with indicators of tumor aggressiveness. (22426956)
2012
18
Extended RET gene analysis in patients with apparently sporadic medullary thyroid cancer: clinical benefits and cost. (22648435)
2012
19
Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer. (21826673)
2012
20
Rearranged anaplastic lymphoma kinase (ALK) gene in adult-onset papillary thyroid cancer amongst atomic bomb survivors. (23050789)
2012
21
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. (21606412)
2011
22
Current role of metaiodobenzylguanidine in the diagnosis of pheochromocytoma and medullary thyroid cancer. (21803186)
2011
23
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. (22105174)
2011
24
Germline RET sequence variation I852M and occult medullary thyroid cancer: harmless polymorphism or causative mutation? (21711375)
2011
25
Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. (20371662)
2010
26
Thyroid cancers amongst goiter population in a Nigerian tertiary hospital: surgical and radiographic perspective. (21526634)
2010
27
The mitogen-activated protein kinase (MAPK) signaling pathway in papillary thyroid cancer. From the molecular bases to clinical practice]. (19627734)
2009
28
Follicular thyroid cancer cell growth inhibition by proteosome inhibitor MG132. (19552924)
2009
29
Medullary thyroid cancer: molecular biology and novel molecular therapies. (19468197)
2009
30
Ablative free thyroxine to thyroglobulin ratio as a predictor of differentiated thyroid cancer recurrence. (19769825)
2009
31
Genetic aspects of familial thyroid cancer. (19465682)
2009
32
The follow-up of patients with differentiated thyroid cancer and undetectable thyroglobulin (Tg) and Tg antibodies during ablation. (18166820)
2008
33
Fluorodeoxyglucose PET/CT in patients with differentiated thyroid cancer and elevated thyroglobulin after total thyroidectomy and (131)I ablation. (17538522)
2008
34
Dysregulated RET signaling in thyroid cancer. (18502331)
2008
35
Predicting the development of Cushing's syndrome in medullary thyroid cancer: utility of proopiomelanocortin messenger ribonucleic acid in situ hybridization. (17696832)
2007
36
Normocalcemic, subclinical, asymptomatic primary hyperparathyroidism in patients with goiter or papillary thyroid cancer--preliminary report. Normocalcemic primary hyperparathyroidism and thyroid pathology. (17966885)
2007
37
Positive predictive value of detectable stimulated tg during the first year after therapy of thyroid cancer and the value of comparison with Tg-ablation and Tg measured after 24 months. (17123341)
2006
38
Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer. (16263812)
2006
39
Risk of thyroid cancer after childhood exposure to ionizing radiation for tinea capitis. (17018661)
2006
40
Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. (15767343)
2005
41
Increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer. (16189643)
2005
42
Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. (15743786)
2005
43
Papillary thyroid cancer with chest metastases only detected using radioactive iodine. (15605906)
2004
44
Treatment of iodine-negative thyroglobulin-positive thyroid cancer: differences in outcome in patients with macrometastases and patients with micrometastases. (15232654)
2004
45
Procedure guidelines for radioiodine therapy of differentiated thyroid cancer (version 2)]. (15316577)
2004
46
Pulmonary epithelioid hemangioendothelioma coexistent with pulmonary metastasis of thyroid cancer. (11518122)
2001
47
Treating the patient with differentiated thyroid cancer with thyroglobulin-positive iodine-131 diagnostic scan-negative metastases: including comments on the role of serum thyroglobulin monitoring in tumor surveillance. (10787191)
2000
48
18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography localizes residual thyroid cancer in patients with negative diagnostic (131)I whole body scans and elevated serum thyroglobulin levels. (10404792)
1999
49
A case of follicular thyroid cancer with tracheal stenosis responded to external radiation therapy. (10378657)
1999
50
Infrequent CDKN2 mutation in human differentiated thyroid cancers. (8561866)
1996

Variations for Thyroid Cancer

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Expression for genes affiliated with Thyroid Cancer

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Search GEO for disease gene expression data for Thyroid Cancer.

Pathways for genes affiliated with Thyroid Cancer

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Pathways related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
EGFR-dependent Endothelin signaling events38
9.9HRAS, EGF, NRAS
2
Show member pathways
9.9HRAS, EGF, NRAS
39.9HRAS, RET, PIK3CA
49.9EGF, HRAS, PIK3CA
5
Show member pathways
9.9HRAS, NRAS, BRAF
69.8PIK3CA, BRAF, HRAS
7
Show member pathways
9.7NRAS, PIK3CA, HRAS, EGF
8
Show member pathways
9.7NRAS, HRAS, BRAF, PIK3CA
99.7NRAS, HRAS, PIK3CA, BRAF
10
Show member pathways
9.7HRAS, EGF, NRAS, BRAF
11
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.7HRAS, CDKN1A, PTEN, PIK3CA
12
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
9.6PPARG, NRAS, HRAS, BRAF
139.6PTEN, BRAF, CDKN1A, HRAS
149.5EGF, RASSF1, BRAF, PIK3CA
159.5PAX8, BRAF, PIK3CA, HRAS
16
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.5CDKN1A, HRAS, PIK3CA, PTEN, NRAS
17
Show member pathways
9.5BRAF, HRAS, RET, NRAS, PIK3CA
18
Show member pathways
9.5NRAS, PIK3CA, EGF, HRAS, BRAF
19
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.5NRAS, PIK3CA, PTEN, BRAF, HRAS
20
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.5PTEN, HRAS, CDKN1A, EGF, PIK3CA
21
Show member pathways
9.4HRAS, EGF, NRAS, BRAF, PTEN
22
Show member pathways
9.4NRAS, HRAS, PIK3CA, CDKN1A, BRAF
239.4HRAS, BRAF, NRAS, CDKN1A, PIK3CA
24
Show member pathways
9.4NRAS, PIK3CA, PPARG, BRAF, HRAS
25
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.4HRAS, PTEN, PIK3CA, BRAF, CDKN1A
269.3PTTG1, PIK3CA, NRAS, CDKN1A, HRAS
279.3PTEN, HRAS, EGF, CDKN1A, NRAS, PIK3CA
28
Show member pathways
9.3CDKN1A, PTEN, HRAS, EGF, NRAS, PIK3CA
29
Show member pathways
9.3PIK3CA, PTEN, NRAS, HRAS, CDKN1A, EGF
30
Show member pathways
9.3EGF, HRAS, CDKN1A, PIK3CA, PTEN, NRAS
31
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.3NRAS, HRAS, RET, BRAF, PIK3CA, EGF
32
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
9.2EGF, HRAS, NRAS, BRAF, PTEN, PIK3CA
33
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.2PIK3CA, BRAF, NRAS, EGF, HRAS, PTEN
349.2EGF, PIK3CA, PTTG1, PTEN, CDKN1A
359.2NRAS, RASSF1, CDKN1A, HRAS, PTEN, PIK3CA
369.2PIK3CA, CDKN1A, HRAS, BRAF, EGF, NRAS
37
Show member pathways
9.2PIK3CA, BRAF, NRAS, CDKN1A, HRAS, EGF
38
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.2PIK3CA, EGF, BRAF, NRAS, HRAS, CDKN1A
399.2EGF, CDKN1A, NRAS, BRAF, PTEN, HRAS
40
Show member pathways
9.2PIK3CA, HRAS, BRAF, NRAS, EGF, RASSF1
41
Show member pathways
9.2BRAF, PPARG, PTEN, NRAS, EGF, HRAS
429.1BRAF, HRAS, NRAS, RET, PAX8, PPARG
43
Show member pathways
Signal transduction PTEN pathway60
9.0PIK3CA, HRAS, EGF, CDKN1A, NRAS, BRAF
44
Show member pathways
9.0BRAF, HRAS, EGF, CDKN1A, NRAS, PTEN
45
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.0PTEN, PIK3CA, BRAF, NRAS, CDKN1A, HRAS
46
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.0PIK3CA, PPARG, PTEN, BRAF, NRAS, EGF
47
Show member pathways
Signaling Pathways in Glioblastoma38
8.8PTEN, NRAS, PIK3CA, EGF, CDKN1A, BRAF
488.7HRAS, PTEN, PIK3CA, BRAF, CALCA, NRAS
49
Show member pathways
8.2KISS1R, HRAS, EGF, PIK3CA, CDKN1A, PTEN
508.0RET, PPARG, HRAS, EGF, CDKN1A, RASSF1

Compounds for genes affiliated with Thyroid Cancer

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Compounds related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1panitumumab45 51 1312.1EGF, BRAF, PTEN
2phenylacetate4510.1HRAS, CDKN1A, PPARG
3mithramycin459.9CDKN1A, PPARG, CALCA
4iodine45 2610.8BRAF, TSHR, TG
5gefitinib45 51 1311.8CDKN1A, EGF, PIK3CA, PTEN
6crcs459.8PTEN, HRAS, RASSF1, BRAF, PIK3CA
7gemcitabine45 51 1311.8PTEN, CDKN1A, EGF, HRAS
8rosiglitazone30 45 51 26 1313.8PPARG, TSHR, CDKN1A, PIK3CA, PTEN
9imatinib45 51 1311.7CDKN1A, PIK3CA, PTEN, BRAF, RET
10phosphotyrosine459.7RET, PIK3CA, HRAS, PTEN, EGF
11lovastatin45 51 61 30 1313.7PTEN, CDKN1A, EGF, HRAS
12calcitriol45 61 26 1312.6EGF, CDKN1A, CALCA, PTEN, TG
13sodium iodide459.6TG, BRAF, PAX8, TSHR, RET, NKX2-1
14thyroxine45 2610.6TG, PAX8, CALCA, TSHR, PPARG
15iodide45 2610.6PIK3CA, TG, BRAF, PAX8, TSHR, NKX2-1
1612-o-tetradecanoylphorbol 13-acetate459.6HRAS, CDKN1A, TSHR, BRAF, RET, EGF
17phosphoinositide459.5BRAF, TSHR, EGF, HRAS, PIK3CA, PTEN
18paclitaxel45 51 1311.5CDKN1A, HRAS, BRAF, PTEN, PIK3CA, EGF
19methionine459.5HRAS, PTEN, TSHR, RET, RASSF1
20aspartate459.5TSHR, PTEN, BRAF, HRAS, TG, RET
21ribonucleic acid459.4TG, PTTG1, RET, PAX8, NKX2-1, TSHR
22pge2459.4PTEN, CALCA, PPARG, CDKN1A, EGF, HRAS
23adenylate459.4CALCA, EGF, TSHR, TG, PIK3CA, HRAS
24pd 98,059459.4HRAS, CDKN1A, BRAF, PTEN, PIK3CA, RET
25wortmannin459.4PIK3CA, EGF, PTEN, CDKN1A, RET, BRAF
26sodium45 2610.4PAX8, TSHR, NKX2-1, HRAS, TG, PIK3CA
27forskolin45 51 1311.4CALCA, TSHR, BRAF, EGF, PAX8, NKX2-1
28rapamycin459.3PIK3CA, EGF, CDKN1A, BRAF, PPARG, PTEN
29arginine459.3TSHR, RET, TG, BRAF, PIK3CA, HRAS
30thymidine45 2610.3HRAS, TSHR, TG, PTTG1, EGF, PIK3CA
31paraffin459.3PTEN, TG, BRAF, RET, CDKN1A, TSHR
32testosterone45 61 26 1312.3PIK3CA, CALCA, PTEN, EGF, RET, TG
33genistein45 30 61 3 26 1314.3EGF, CDKN1A, PTEN, PPARG, PIK3CA, TG
34progesterone45 30 61 26 1313.2CDKN1A, PTEN, HRAS, PIK3CA, BRAF, TSHR
35cyclic amp45 2610.2HRAS, NKX2-1, TSHR, CALCA, RET, EGF
36ly294002459.2RET, PIK3CA, HRAS, EGF, CDKN1A, PTEN
37cisplatin45 51 61 1312.2EGF, PIK3CA, PTEN, HRAS, BRAF, TG
38phosphatidylinositol459.1PIK3CA, PTTG1, PTEN, BRAF, TSHR, RET
39alanine459.0PPARG, KISS1R, RASSF1, RET, TSHR, BRAF
40h2o2459.0PIK3CA, PTEN, TG, CDKN1A, EGF, HRAS
41cysteine458.9TG, TSHR, PTTG1, PTEN, RET, EGF
42oligonucleotide458.7RASSF1, PTEN, BRAF, PAX8, TSHR, RET
43threonine458.5RET, PTEN, BRAF, PAX8, TSHR, HRAS
44agar458.5HRAS, CDKN1A, RASSF1, NRAS, RET, BRAF
45tyrosine458.4BRAF, TG, HRAS, PTEN, TSHR, RET
46retinoic acid45 269.4EGF, CDKN1A, RASSF1, NKX2-1, TSHR, PIK3CA
47calcium45 51 26 1311.4CALCA, KISS1R, PTEN, EGF, HRAS, PIK3CA
48serine458.3HRAS, BRAF, TG, CDKN1A, RASSF1, NKX2-1
49vegf458.2PIK3CA, PTTG1, HRAS, PTEN, TSHR, PPARG
50estrogen458.0PPARG, BRAF, HRAS, EGF, PIK3CA, PTTG1

GO Terms for genes affiliated with Thyroid Cancer

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Cellular components related to Thyroid Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058868.5PTEN, BRAF, TSHR, NRAS, RASSF1, KISS1R
2cytosolGO:00058298.1HRAS, NNMT, PPARG, PIK3CA, PTTG1, PTEN

Biological processes related to Thyroid Cancer according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Rac protein signal transductionGO:003502210.3NRAS, HRAS
2regulation of synaptic transmission, GABAergicGO:003222810.3HRAS, NRAS
3thyroid-stimulating hormone signaling pathwayGO:003819410.3PAX8, TSHR
4thyroid gland developmentGO:003087810.1NKX2-1, PAX8, TG
5positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:0200006010.1PTEN, EGF
6MAPK cascadeGO:000016510.1RET, NRAS, HRAS
7endothelial cell migrationGO:004354210.1PIK3CA, PTEN, CALCA
8striated muscle cell differentiationGO:005114610.0HRAS, NRAS
9response to arsenic-containing substanceGO:004668510.0PTEN, CDKN1A
10Ras protein signal transductionGO:000726510.0NRAS, RASSF1, CDKN1A, HRAS
11negative regulation of neuron apoptotic processGO:004352410.0HRAS, NRAS, BRAF, PIK3CA
12leukocyte migrationGO:00509009.9HRAS, NRAS, PIK3CA
13phosphatidylinositol-mediated signalingGO:00480159.9EGF, CDKN1A, PTEN, PIK3CA
14organ regenerationGO:00311009.8NNMT, PPARG, CDKN1A
15positive regulation of cell proliferationGO:00082849.8HRAS, EGF, NRAS, TSHR, PTEN
16activation of MAPKK activityGO:00001869.7BRAF, NRAS, KISS1R, EGF, HRAS
17negative regulation of cell proliferationGO:00082859.7PTEN, RNF139, KISS1R, CDKN1A, HRAS
18Fc-epsilon receptor signaling pathwayGO:00380959.6PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
19epidermal growth factor receptor signaling pathwayGO:00071739.6PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
20positive regulation of transcription, DNA-templatedGO:00458939.5EGF, NKX2-1, RET, PAX8, PPARG
21response to drugGO:00424939.5NNMT, PPARG, PTEN, RET, CDKN1A
22fibroblast growth factor receptor signaling pathwayGO:00085439.4HRAS, PIK3CA, PTEN, BRAF, NRAS, CDKN1A
23innate immune responseGO:00450879.4PPARG, PIK3CA, PTEN, NRAS, CDKN1A, EGF
24neurotrophin TRK receptor signaling pathwayGO:00480119.4PIK3CA, PTEN, BRAF, NRAS, CDKN1A, EGF
25protein phosphorylationGO:00064689.2BRAF, RET, CALCA, CDKN1A

Molecular functions related to Thyroid Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid-stimulating hormone receptor activityGO:000499610.0PAX8, TSHR
2protein bindingGO:00055156.4PPARG, PIK3CA, PTTG1, PTEN, BRAF, PAX8

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
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