MCID: THY028
MIFTS: 73

Thyroid Cancer malady

Cancer, Endocrine categories

Summaries for Thyroid Cancer

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it makes hormones that help the body work normally. there are several types of cancer of the thyroid gland. you are at greater risk if you are between ages 25 and 65 are a woman are asian have a family member who has had thyroid disease have had radiation treatments to your head or neck you should see a doctor if you have a lump or swelling in your neck. doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose thyroid cancer. treatment depends on the type of cancer you have and how far the cancer has spread. many patients receive a combination of treatments. they may include surgery, radioactive iodine, hormone treatment, radiation therapy, chemotherapy, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Thyroid Cancer, also known as thyroid carcinoma, is related to thyroid cancer, anaplastic and thyroiditis. An important gene associated with Thyroid Cancer is NKX2-1 (NK2 homeobox 1), and among its related pathways are Signaling by GPCR and Pathways in cancer. The drugs interferon alfa-2b and thyroglobulin and the compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include the thryoid gl, skin and ovary, and related mouse phenotypes are growth/size and mortality/aging.

Disease Ontology:8 An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.

Wikipedia:64 Thyroid cancer is a malignant neoplasm originating from follicular or parafollicular thyroid cells. more...

Aliases & Classifications for Thyroid Cancer

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Endocrine


Aliases & Descriptions:

thyroid cancer 8 10 45 34
thyroid carcinoma 8 45 61
thyroid neoplasm 8 61
malignant neoplasm of thyroid gland 8
malignant tumour of thyroid gland 8
head and neck cancer, thyroid 8
malignant neoplasm of thyroid 61
neoplasm of thyroid gland 8
thyroid gland neoplasm 8
thyroid neoplasms 45


External Ids:

Disease Ontology8 DOID:1781, DOID:3963
ICD9CM27 193
NCIt40 C7510, C4815
MeSH35 D013964
ICD1025 C73

Related Diseases for Thyroid Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Thyroid Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 347)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid cancer, anaplastic31.4TSHR, EGF, PIK3CA, PPARG, CALCA, BRAF
2thyroiditis30.9CALCA, TSHR, TG
3papillary carcinoma30.8PPARG, CALCA, BRAF, NKX2-1, PAX8, HRAS
4adenoma30.7TG, PAX8, PTTG1, TSHR, RASSF1, HRAS
5thyroid adenoma30.7BRAF, PIK3CA, RET, RASSF1, PPARG, TG
6graves' disease30.7TG, PAX8, TSHR, NKX2-1
7squamous cell carcinoma30.6CDKN1A, PTTG1, PTEN, RASSF1, HRAS, EGF
8multinodular goiter30.6CALCA, TG, TSHR
9nodular goiter30.6RET, BRAF, TSHR, TG, HRAS, CALCA
10multiple endocrine neoplasia30.6TG, RET, CALCA
11thyroid medullary carcinoma30.5CALCA, BRAF, NKX2-1, TG, RET
12struma ovarii30.5TSHR, NKX2-1, TG
13adenocarcinoma30.4PTTG1, BRAF, PTEN, PIK3CA, RASSF1, HRAS
14familial adenomatous polyposis30.4RASSF1, NRAS, PPARG, BRAF
15thyroid carcinoma, follicular, somatic30.4PTEN, HRAS
16endemic goiter30.4TSHR, TG
17thyrotoxicosis30.4TSHR, TG
18phaeochromocytoma30.4CALCA, RET
19paraganglioma30.3TG, RET, CALCA
20insulin resistance30.3PIK3CA, PPARG
21autoimmune thyroiditis30.3TG
22colorectal cancer30.2EGF, CDKN1A, HRAS, RASSF1, PPARG, BRAF
23teratoma30.2NKX2-1, TG
24familial medullary thyroid carcinoma30.2CALCA, RET
25nontoxic goiter30.2TG, TSHR
26thymoma30.2NKX2-1
27thyroid agenesis30.1TSHR, TG, PAX8, NKX2-1
28acute leukemia30.1HRAS, PIK3CA
29pituitary tumors30.1PTTG1, PPARG
30myxedema29.9TSHR, TG
31astrocytoma29.9PTTG1, EGF, PIK3CA, CDKN1A, PTEN, RASSF1
32wilms tumor29.9RASSF1, PAX8, NKX2-1
33brain cancer29.9PIK3CA, EGF, CDKN1A, PTEN
34cowden disease29.9PIK3CA, PTEN, RET
35subacute thyroiditis29.9TSHR, TG
36ataxia telangiectasia29.8CDKN1A, PIK3CA
37celiac disease29.8TG
38bone carcinoma10.6
39cribriform carcinoma10.5
40vascular cancer10.5
41thyroid hurthle cell carcinoma10.5
42thyroid cancer, childhood10.4
43tall cell variant papillary carcinoma10.4
44papillary squamous carcinoma10.4
45trachea carcinoma10.3
46pheochromocytoma10.3
47breast papillary carcinoma10.3
48adrenal carcinoma10.3
49mucoepidermoid thyroid carcinoma10.3
50nonmedullary thyroid carcinoma, with or without cell oxyphilia10.3

Graphical network of the top 20 diseases related to Thyroid Cancer:



Diseases related to thyroid cancer

Clinical Features for Thyroid Cancer

Drugs & Therapeutics for Thyroid Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Thyroid Cancer

Drug clinical trials:

Search ClinicalTrials for Thyroid Cancer

Search NIH Clinical Center for Thyroid Cancer

Search CenterWatch for Thyroid Cancer

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Thyroid Cancer

Anatomical Context for Thyroid Cancer

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Thyroid Cancer:

33
Skin, Ovary, Liver, Brain, Lymph node, Lung, Whole blood, Thymus, Colon, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Prostate, Testis, Cervix, Myeloid, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Appendix, Fetal thyroid, Pancreatic islet, Pituitary

FMA organs/tissues related to Thyroid Cancer:

14
The thryoid gl

Animal Models for Thyroid Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Thyroid Cancer:

37 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537812.9NRAS, NKX2-1, EGF, PIK3CA, PPARG, BRAF
2MP:001076812.9BRAF, CALCA, PPARG, PIK3CA, NKX2-1, NRAS
3MP:000538512.5BRAF, CALCA, PPARG, PIK3CA, NKX2-1, NRAS
4MP:000538612.4NKX2-1, PIK3CA, PPARG, CALCA, BRAF, CDKN1A
5MP:000538712.4BRAF, PPARG, PIK3CA, EGF, NRAS, CDKN1A
6MP:000200612.4BRAF, CALCA, PPARG, PIK3CA, NKX2-1, NRAS
7MP:000538412.4NRAS, NKX2-1, PIK3CA, PPARG, BRAF, CDKN1A
8MP:000537912.2TG, PIK3CA, EGF, CDKN1A, RET, HRAS
9MP:000363112.2PPARG, NKX2-1, CDKN1A, RET, HRAS, KISS1R
10MP:000287312.1BRAF, CALCA, PPARG, EGF, NRAS, RET
11MP:000538912.1BRAF, PIK3CA, EGF, CDKN1A, RET, PAX8
12MP:000539712.0BRAF, PPARG, NRAS, CDKN1A, RET, KISS1R
13MP:000301212.0PPARG, PIK3CA, NKX2-1, NRAS, CDKN1A, RET
14MP:000537611.9CALCA, PIK3CA, NRAS, RET, KISS1R, PAX8
15MP:000538111.8BRAF, EGF, NKX2-1, NRAS, CDKN1A, RET
16MP:001077111.7CALCA, PIK3CA, NRAS, CDKN1A, HRAS, KISS1R
17MP:000536711.5PPARG, RET, KISS1R, PAX8, PTTG1
18MP:000537011.3PPARG, NRAS, CDKN1A, KISS1R, PTEN, BRAF
19MP:000538011.3PPARG, RET, PAX8, PTTG1
20MP:000539011.1NKX2-1, CDKN1A, HRAS, PAX8
21MP:000538810.8CDKN1A, PTEN
22MP:000537510.7PTTG1
23MP:000539110.7EGF, PPARG
24MP:000537710.5TSHR, PAX8

Publications for Thyroid Cancer

Sources:
51PubMed
See all sources

Articles related to Thyroid Cancer:

(show top 50)    (show all 1772)
idTitleAuthorsYear
1
A Fas-Associated via Death Domain Promoter Polymorphism (rs10898853, -16C/T) as a Risk Factor for Papillary Thyroid Cancer. (24434721)
2014
2
Update: The Status of Clinical Trials of Kinase Inhibitors in Thyroid Cancer. (24423326)
2014
3
Commentary on: Implications of thyroglobulin antibody positivity in patients with differentiated thyroid cancer: a clinical position statement. (23987661)
2013
4
Successful use of sorafenib after bortezomib failure in metastatic follicular thyroid cancer - a case report. (23774152)
2013
5
Anaplastic thyroid cancer: ultrasonographic findings and the role of ultrasonography-guided fine needle aspiration biopsy. (24142644)
2013
6
Histone deacetylation of NIS promoter underlies BRAF V600E-promoted NIS silencing in thyroid cancer. (24243688)
2013
7
Metastatic mechanisms in follicular cell-derived thyroid cancer. (24036131)
2013
8
Chemotherapy for anaplastic thyroid cancer using docetaxel and cisplatin: report of eight cases. (24122002)
2013
9
Clinical comments related to medullary thyroid cancer diagnosis and management. (23514614)
2013
10
"Is there any association between insulin resistance and thyroid cancer? : a case control study" (23564559)
2013
11
Influence of chronic autoimmune thyroiditis and papillary thyroid cancer on serum calcitonin levels. (23327335)
2013
12
Genetic screening in families with multiple endocrine neoplasia type 2A for possible medullary thyroid cancer. (23595407)
2013
13
RTN4IP1 is down-regulated in thyroid cancer and has tumor-suppressive function. (23393170)
2013
14
Is above age 45 appropriate for upstaging well-differentiated papillary thyroid cancer? (24013977)
2013
15
Comparison of surgical outcomes between papillary thyroid cancer patients treated with theA Harmonic ACE scalpel and LigaSure Precise instrument during conventional thyroidectomy: aA single-blind prospective randomized controlledA trial. (24332551)
2013
16
Prototype imaging protocols for monitoring the efficacy of iodine-131 ablation in differentiated thyroid cancer. (24137580)
2013
17
Dickkopf-1 inhibits thyroid cancer cell survival and migration through regulation of I^-catenin/E-cadherin signaling. (23261982)
2013
18
E-cadherin expression is more associated with histopathological type of thyroid cancer than with the metastatic potential of tumors. (23264214)
2012
19
MiR-365 regulates lung cancer and developmental gene thyroid transcription factor 1. (22185756)
2012
20
Down-regulation of matrix metalloproteinase-7 inhibits metastasis of human anaplastic thyroid cancer cell line. (22042554)
2012
21
HER2-positive male breast cancer with thyroid cancer: an institutional report and review of literature. (22585608)
2012
22
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. (22105174)
2011
23
Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFI^ signaling. (21383698)
2011
24
Down-regulation of I^-N-acetyl-D-glucosaminidase increases Akt1 activity in thyroid anaplastic cancer cells. (21637923)
2011
25
Recombinant human thyrotropin in follow-up of patients with differentiated thyroid cancer. (20429310)
2010
26
F-18 FDG-PET/CT evaluation of patients with differentiated thyroid cancer with negative I-131 total body scan and high thyroglobulin level. (19851169)
2009
27
Regulation of uptake of 18F-FDG by a follicular human thyroid cancer cell line with mutation-activated K-ras. (19652218)
2009
28
Notch1 mediates growth suppression of papillary and follicular thyroid cancer cells by histone deacetylase inhibitors. (19190121)
2009
29
Lessons from a review of thyroglobulin assays in the management of thyroid cancer. (18613899)
2008
30
Targeted therapeutic approach for an anaplastic thyroid cancer in vitro and in vivo. (18616678)
2008
31
Association between decreased WWOX protein expression and thyroid cancer development. (18047428)
2007
32
Risk of thyroid cancer after childhood exposure to ionizing radiation for tinea capitis. (17018661)
2006
33
Specific subtelomere loss on chromosome der(11)t(3;11)(q23;q23)x2 in anaplastic thyroid cancer cell line OCUT-1. (16786150)
2006
34
Smoking and susceptibility to thyroid cancer: an inverse association with CYP1A1 allelic variants. (17158763)
2006
35
Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. (15743786)
2005
36
Profile of thyroid hormones in breast cancer patients. (15917958)
2005
37
Disturbed expression of type 1 and type 2 iodothyronine deiodinase as well as titf1/nkx2-1 and pax-8 transcription factor genes in papillary thyroid cancer. (16279847)
2005
38
Gene therapy for thyroid cancer: current status and future prospects. (15242569)
2004
39
Gene therapy of thyroid cancer via retrovirally-driven combined expression of human interleukin-2 and herpes simplex virus thymidine kinase. (12534360)
2003
40
Radioiodine lobar ablation as an alternative to completion thyroidectomy in patients with differentiated thyroid cancer. (12548045)
2003
41
The helix-loop-helix protein, Id-1, is overexpressed and regulates growth in papillary thyroid cancer. (12947323)
2003
42
Evaluation of germline sequence variants of GFRA1, GFRA2, and GFRA3 genes in a cohort of Spanish patients with sporadic medullary thyroid cancer. (12490080)
2002
43
Management of papillary and follicular (differentiated) thyroid cancer: new paradigms using recombinant human thyrotropin. (12542401)
2002
44
Serum thyroglobulin measurements in differentiated thyroid cancer. (10989968)
2000
45
Non-131I-scintigraphy in the treatment and follow-up of thyroid cancer. Single-photon-emitters or FDG-PET? (10568135)
1999
46
Diagnostic value of technetium-99m methoxyisobutyl isonitrile (99mTc-MIBI) scintigraphy in detecting thyroid cancer metastases: a critical evaluation. (9920363)
1998
47
Role of non surgical therapeutics in the treatment of patients with medullary cancer of the thyroid]. (8734287)
1996
48
Radioiodine therapy for thyroid cancer. (8608780)
1995
49
Unusual association of somatostatin-secreting thyroid cancer and a calcitonin-secreting duodenal endocrine tumor. Is it an entity?]. (7912917)
1993
50
Studies on human cancer using sponge matrix tissue culture. I. The growth patterns of a malignant melanoma, adenocarcinoma of the parotid gland, papillary adenocarcinoma of the thyroid gland, adenocarcinoma of the pancreas, and epidermoid carcinoma of the uterine cervix (Gey's HeLa strain). (13238257)
1954

Genetic Variations for Thyroid Cancer

Expression for genes affiliated with Thyroid Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Thyroid Cancer

Search GEO for disease gene expression data for Thyroid Cancer.

Pathways for genes affiliated with Thyroid Cancer

Sources:
54Reactome, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 50PharmGKB, 60Tocris Bioscience, 53R&D Systems
See all sources

Pathways related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.9NRAS, EGF, BRAF, PTEN, CALCA, PIK3CA
211.7CDKN1A, BRAF, PPARG, PIK3CA, EGF, NRAS
3
Hide members
11.5HRAS, NRAS, CDKN1A, EGF, PTEN, PIK3CA
411.3CDKN1A, NRAS, PIK3CA, HRAS, PTEN, RASSF1
5
Hide members
11.3PIK3CA, EGF, CDKN1A, PTEN, HRAS, NRAS
6
Hide members
11.3NRAS, PIK3CA, CDKN1A, EGF, HRAS, PTEN
711.3HRAS, PTEN, EGF, NRAS, PIK3CA, CDKN1A
811.3PTEN, HRAS, NRAS, PIK3CA, EGF, CDKN1A
9
Hide members
11.3PIK3CA, CDKN1A, HRAS, PTEN, EGF, NRAS
10
Hide members
11.3PIK3CA, EGF, PTEN, HRAS, NRAS, BRAF
11
Hide members
11.3PIK3CA, EGF, NRAS, HRAS, PTEN, BRAF
12
Translation Insulin regulation of translation
Hide members
11.3HRAS, NRAS, EGF, PTEN, PIK3CA, BRAF
13
Hide members
11.3BRAF, EGF, CDKN1A, HRAS, NRAS, PIK3CA
14
Hide members
11.3NRAS, BRAF, EGF, CDKN1A, HRAS, PIK3CA
1511.3EGF, BRAF, PIK3CA, NRAS, HRAS, CDKN1A
16
Hide members
11.3PTEN, HRAS, NRAS, EGF, PPARG, BRAF
1711.3HRAS, CDKN1A, EGF, BRAF, NRAS, PTEN
18
Hide members
11.3PIK3CA, BRAF, HRAS, EGF, NRAS, RET
1911.3RET, PAX8, BRAF, PPARG, NRAS, HRAS
20
Hide members
11.2NRAS, PIK3CA, CDKN1A, HRAS, PTEN
21
Hide members
11.2HRAS, BRAF, NRAS, EGF, PIK3CA
22
Hide members
11.2HRAS, BRAF, PIK3CA, NRAS, PTEN
23
Hide members
11.2BRAF, PTEN, HRAS, NRAS, EGF
24
Hide members
11.2HRAS, PIK3CA, NRAS, PPARG, BRAF
2511.2BRAF, NRAS, CDKN1A, HRAS, PIK3CA
26
Transcription Androgen Receptor nuclear signaling
Hide members
11.2EGF, PTEN, CDKN1A, PIK3CA, HRAS
27
Hide members
11.2PTEN, CDKN1A, PIK3CA, BRAF, HRAS
28
Hide members
11.2HRAS, RET, NRAS, PIK3CA, BRAF
2911.2PTTG1, PIK3CA, NRAS, CDKN1A, HRAS
3011.2CDKN1A, EGF, PIK3CA, PTEN, PTTG1
31
Hide members
11.0EGF, HRAS, PIK3CA, NRAS
32
Hide members
11.0EGF, HRAS, NRAS, PIK3CA
33
Hide members
11.0NRAS, EGF, HRAS, BRAF
34
Hide members
11.0BRAF, PTEN, HRAS, NRAS
35
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
11.0BRAF, PPARG, HRAS, NRAS
36
Development Ligand-independent activation of ESR1 and ESR2
Hide members
11.0PPARG, PIK3CA, EGF, HRAS
37
Hide members
11.0BRAF, CDKN1A, HRAS, NRAS
38
Hide members
11.0PIK3CA, HRAS, PTEN, CDKN1A
3911.0BRAF, EGF, RASSF1, PIK3CA
4011.0BRAF, CDKN1A, HRAS, PTEN
4111.0PIK3CA, BRAF, PAX8, HRAS
4210.9PIK3CA, NRAS, HRAS
43
Hide members
10.9HRAS, NRAS, PIK3CA
44
Hide members
10.9EGF, NRAS, HRAS
45
Hide members
10.9HRAS, NRAS, BRAF
46
Hide members
10.9BRAF, NRAS, HRAS
4710.9EGF, HRAS, PIK3CA
48
G-protein signaling Cross-talk between Ras-family GTPases
Hide members
10.9HRAS, PIK3CA, BRAF
4910.9RET, PIK3CA, HRAS
50
G-protein signaling H-RAS regulation pathway
Hide members
10.9HRAS, PIK3CA, RET

Compounds for genes affiliated with Thyroid Cancer

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1vegf4512.6PTTG1, PTEN, HRAS, CALCA, CDKN1A, EGF
2retinoic acid45 2413.6PIK3CA, TSHR, TG, RASSF1, HRAS, RET
3tyrosine4512.6HRAS, RET, NRAS, NKX2-1, TSHR, EGF
4agar4512.5RET, HRAS, PTEN, CDKN1A, NRAS, EGF
5threonine4512.5PIK3CA, BRAF, EGF, HRAS, TSHR, CDKN1A
6oligonucleotide4512.3BRAF, NKX2-1, NRAS, CDKN1A, RET, HRAS
7ly2940024512.0BRAF, PTEN, HRAS, RET, CDKN1A, EGF
8calcium45 50 11 2415.0PTTG1, HRAS, PTEN, RET, TSHR, KISS1R
9paraffin4512.0TG, BRAF, RET, HRAS, NKX2-1, TSHR
10genistein45 29 60 2 11 2417.0RET, CDKN1A, PTEN, HRAS, TG, EGF
11cisplatin45 50 60 1115.0TG, HRAS, RASSF1, PIK3CA, EGF, BRAF
12cyclic amp45 2413.0BRAF, CALCA, PTEN, TSHR, HRAS, RET
13progesterone45 60 29 11 2416.0NKX2-1, BRAF, PIK3CA, EGF, CDKN1A, HRAS
14phosphatidylinositol4512.0EGF, RET, PTTG1, TSHR, PIK3CA, BRAF
15alanine4511.9TG, PTEN, BRAF, TSHR, PPARG, KISS1R
16serine4511.9RASSF1, HRAS, RET, NKX2-1, PAX8, PIK3CA
17rapamycin4511.9PIK3CA, PPARG, BRAF, PTEN, HRAS, CDKN1A
18pd 98,0594511.9PIK3CA, EGF, CDKN1A, RET, BRAF, HRAS
19wortmannin4511.9EGF, PIK3CA, BRAF, CDKN1A, RET, PTEN
20thymidine45 2412.8PTTG1, PIK3CA, EGF, CDKN1A, HRAS, TSHR
21testosterone45 60 11 2414.8RET, TG, PTEN, EGF, PPARG, PIK3CA
22sodium iodide4511.8TSHR, PAX8, RET, NKX2-1, BRAF, TG
23arginine4511.7TSHR, PTEN, HRAS, PIK3CA, BRAF, RET
24ribonucleic acid4511.7TSHR, RET, PTTG1, NKX2-1, TG, PAX8
2512-o-tetradecanoylphorbol 13-acetate4511.7BRAF, CDKN1A, EGF, TSHR, HRAS, RET
26paclitaxel45 50 1113.7BRAF, PIK3CA, EGF, CDKN1A, HRAS, PTEN
27phosphoinositide4511.6TSHR, HRAS, PIK3CA, EGF, BRAF, PTEN
28forskolin45 50 1113.6EGF, CALCA, TSHR, PAX8, NKX2-1, BRAF
29iodide45 2412.6PAX8, BRAF, PIK3CA, NKX2-1, TG
30crcs4511.6PTEN, PIK3CA, RASSF1, HRAS, BRAF
31aspartate4511.6PTEN, HRAS, TG, RET, BRAF, TSHR
32rosiglitazone45 50 29 11 2415.5PIK3CA, CDKN1A, PTEN, TSHR, PPARG
33thyroxine45 2412.5TSHR, TG, PAX8, CALCA, PPARG
34imatinib45 50 1113.5BRAF, PIK3CA, CDKN1A, PTEN, RET
35calcitriol45 60 11 2414.5CDKN1A, CALCA, EGF, PTEN, TG
36phosphotyrosine4511.4EGF, PIK3CA, RET, HRAS, PTEN
37adenylate4511.4CALCA, PIK3CA, TG, TSHR, EGF, HRAS
38estrogen4511.3TG, TSHR, PTTG1
39h2o24511.3PTEN, EGF, CDKN1A, HRAS, TG, PIK3CA
40gefitinib45 50 1113.3PTEN, CDKN1A, EGF, PIK3CA
41panitumumab45 50 1113.3PTEN, EGF, BRAF
42gemcitabine45 50 1113.2CDKN1A, HRAS, EGF, PTEN
43phenylacetate4511.2HRAS, CDKN1A, PPARG
44pge24511.2HRAS, CDKN1A, PTEN
45lovastatin45 50 60 29 1115.1PTEN, CDKN1A, EGF, HRAS
46sodium45 2412.1TG, PAX8
47methionine4511.1HRAS, RASSF1, PTEN, TSHR, RET
48iodine45 2412.1TG, TSHR, BRAF
49manumycin4510.9CDKN1A, EGF, HRAS
50gf 109203x45 6011.7CDKN1A, HRAS, PPARG, EGF

GO Terms for genes affiliated with Thyroid Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Thyroid Cancer according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathwayGO:00854311.8PTEN, HRAS, CDKN1A, NRAS, EGF, PIK3CA
2neurotrophin TRK receptor signaling pathwayGO:04801111.8BRAF, PIK3CA, EGF, NRAS, CDKN1A, HRAS
3innate immune responseGO:04508711.7PPARG, PIK3CA, EGF, NRAS, CDKN1A, HRAS
4Fc-epsilon receptor signaling pathwayGO:03809511.6PIK3CA, EGF, NRAS, CDKN1A, HRAS, PTEN
5epidermal growth factor receptor signaling pathwayGO:00717311.6PIK3CA, EGF, NRAS, CDKN1A, HRAS, PTEN
6activation of MAPKK activityGO:00018611.5BRAF, EGF, NRAS, HRAS, KISS1R
7negative regulation of cell proliferationGO:00828511.4CDKN1A, RNF139, HRAS, KISS1R, PTEN
8Ras protein signal transductionGO:00726511.3NRAS, CDKN1A, HRAS, RASSF1
9positive regulation of cell proliferationGO:00828411.3EGF, NRAS, HRAS, PTEN, TSHR
10phosphatidylinositol-mediated signalingGO:04801511.2PIK3CA, EGF, CDKN1A, PTEN
11positive regulation of transcription, DNA-dependentGO:04589311.2PPARG, EGF, NKX2-1, RET, PAX8
12thyroid gland developmentGO:03087811.1TG, PAX8, NKX2-1
13endothelial cell migrationGO:04354211.1CALCA, PIK3CA, PTEN
14MAPK cascadeGO:00016511.0HRAS, RET, NRAS
15positive regulation of Rac protein signal transductionGO:03502210.9HRAS, NRAS
16positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.8PTEN, EGF
17regulation of synaptic transmission, GABAergicGO:03222810.7HRAS, NRAS
18striated muscle cell differentiationGO:05114610.5HRAS, NRAS

Molecular functions related to Thyroid Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.4TSHR, BRAF, CALCA, PPARG, PIK3CA, EGF
2thyroid-stimulating hormone receptor activityGO:00499610.8TSHR, PAX8

Products for genes affiliated with Thyroid Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thyroid Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet