MCID: THY028
MIFTS: 63

Thyroid Cancer malady

Cancer diseases, Endocrine diseases categories

Aliases & Classifications for Thyroid Cancer

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Thyroid Cancer, Aliases & Descriptions:

Name: Thyroid Cancer 9 11 43 32
Thyroid Carcinoma 9 43 60
Thyroid Neoplasm 9 60
Malignant Neoplasm of Thyroid Gland 9
Malignant Tumour of Thyroid Gland 9
 
Head and Neck Cancer, Thyroid 9
Malignant Neoplasm of Thyroid 60
Neoplasm of Thyroid Gland 9
Thyroid Gland Neoplasm 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:1781, DOID:3963
NCIt38 C7510, C4815
ICD9CM27 193
MeSH33 D013964
ICD1025 C73

Summaries for Thyroid Cancer

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MedlinePlus:32 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it makes hormones that help the body work normally. there are several types of cancer of the thyroid gland. you are at greater risk if you are between ages 25 and 65 are a woman are asian have a family member who has had thyroid disease have had radiation treatments to your head or neck you should see a doctor if you have a lump or swelling in your neck. doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose thyroid cancer. treatment depends on the type of cancer you have and how far the cancer has spread. many patients receive a combination of treatments. they may include surgery, radioactive iodine, hormone treatment, radiation therapy, chemotherapy, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards based summary: Thyroid Cancer, also known as thyroid carcinoma, is related to thyroiditis and thyroid carcinoma, follicular. An important gene associated with Thyroid Cancer is NKX2-1 (NK2 homeobox 1), and among its related pathways are EGFR Transactivation by Gastrin and SHC1 events in ERBB2 signaling. The drugs interferon alfa-2b and thyroglobulin and the compounds panitumumab and phenylacetate have been mentioned in the context of this disorder. Affiliated tissues include the thryoid gl, thyroid and testes, and related mouse phenotypes are muscle and adipose tissue.

Disease Ontology:9 An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.

Wikipedia:63 Thyroid cancer is a cancer originating from follicular or parafollicular thyroid cells. more...

Related Diseases for Thyroid Cancer

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Diseases related to Thyroid Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 312)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis32.8TG, TSHR, CALCA
2thyroid carcinoma, follicular31.3PTEN, NRAS, HRAS
3struma ovarii31.3TG, TSHR, NKX2-1
4multiple endocrine neoplasia31.2TG, RET, CALCA
5multinodular goiter31.2CALCA, TSHR, TG
6endemic goiter31.1TG, TSHR
7graves' disease31.1TG, PAX8, TSHR, NKX2-1
8hypothyroidism31.0NKX2-1, TSHR, TG
9goiter31.0TG, BRAF, PAX8, TSHR, RET, CALCA
10thyrotoxicosis31.0TG, TSHR
11autoimmune thyroiditis31.0TG, CALCA
12medullary thyroid carcinoma, familial31.0RET, CALCA
13paraganglioma30.8TG, RET, CALCA
14subacute thyroiditis30.8TG, TSHR
15nodular goiter30.8TG, BRAF, TSHR, RET, CALCA, HRAS
16pituitary adenoma30.6RET, PTTG1, PPARG
17neuroma30.6RET, CALCA
18nontoxic goiter30.5TG, TSHR
19retinoblastoma30.5PPARG, PIK3CA, RASSF1, CDKN1A, EGF, HRAS
20myxedema30.5TSHR, TG
21hashimoto thyroiditis30.5TG, BRAF, TSHR, RET, CALCA
22cowden disease30.5RET, PTEN, PIK3CA
23neuroendocrine tumor30.4PAX8, RET, CALCA, NKX2-1, RASSF1
24islet cell tumor30.4RET, CALCA
25leukemia30.3PIK3CA, PTTG1, TSHR, NRAS, CDKN1A, EGF
26glioblastoma multiforme30.3PIK3CA, PTEN, CDKN1A, EGF
27adenomatous polyposis coli30.3PPARG, BRAF, NRAS, RASSF1
28brain cancer30.2PIK3CA, PTEN, CDKN1A, EGF
29melanoma30.2PIK3CA, PTEN, BRAF, TSHR, NKX2-1, NRAS
30adenocarcinoma30.1PIK3CA, PTTG1, PTEN, BRAF, NKX2-1, RASSF1
31breast cancer30.0PIK3CA, PTTG1, PTEN, NKX2-1, RASSF1, CDKN1A
32papillary carcinoma30.0PAX8, TSHR, RET, CALCA, NKX2-1, HRAS
33thyroid adenoma30.0PPARG, PIK3CA, PTEN, TG, BRAF, TSHR
34glioblastoma29.9PPARG, PIK3CA, PTEN, RASSF1, CDKN1A, EGF
35astrocytoma29.8PIK3CA, PTTG1, PTEN, RASSF1, CDKN1A, EGF
36hepatocellular carcinoma29.6PIK3CA, PTTG1, PTEN, NKX2-1, RASSF1, KISS1R
37thyroid carcinoma, papillary29.5EGF, CDKN1A, KISS1R, NNMT, PPARG, PIK3CA
38thyroid cancer, anaplastic29.5PAX8, TSHR, RET, CALCA, NKX2-1, CDKN1A
39adenoma29.5PPARG, PTTG1, TG, BRAF, PAX8, TSHR
40follicular adenoma29.4PPARG, PTEN, TG, BRAF, PAX8, TSHR
41cervicitis10.6
42leopard syndrome10.6HRAS
43endotheliitis10.5
44cowden syndrome 110.5PTEN
45thyroid carcinoma, hurthle cell10.5
46familial papillary thyroid carcinoma10.5
47toxic diffuse goiter10.5TSHR, TG
48cardiofaciocutaneous syndrome10.4BRAF
49hyperthyroidism10.4
50spitz nevus10.4BRAF, HRAS

Graphical network of the top 20 diseases related to Thyroid Cancer:



Diseases related to thyroid cancer

Symptoms for Thyroid Cancer

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Drugs & Therapeutics for Thyroid Cancer

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Genetic Tests for Thyroid Cancer

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Anatomical Context for Thyroid Cancer

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MalaCards organs/tissues related to Thyroid Cancer:

31
Thyroid, Testes, Lymph node, Endothelial, Bone, Lung, Pituitary, Breast, T cells, Liver, Salivary gland, Skin, Ovary, Myeloid, Thymus, Brain, Colon, Prostate, Testis, Cervix, Nk cells

FMA organs/tissues related to Thyroid Cancer:

14
The thryoid gl

Animal Models for Thyroid Cancer or affiliated genes

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MGI Mouse Phenotypes related to Thyroid Cancer:

35 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1CDKN1A, RET, BRAF, PTEN, PIK3CA, PPARG
2MP:00053759.1PPARG, PIK3CA, PTTG1, PTEN, BRAF, CDKN1A
3MP:00053889.0PTEN, BRAF, RET, CALCA, NKX2-1, CDKN1A
4MP:00053708.9PPARG, PTEN, BRAF, NRAS, KISS1R, CDKN1A
5MP:00053918.9PPARG, PIK3CA, PTEN, BRAF, NRAS, CDKN1A
6MP:00053818.9PTEN, BRAF, RET, NKX2-1, NRAS, KISS1R
7MP:00053778.9PPARG, PAX8, TSHR, CALCA, CDKN1A
8MP:00053908.7PPARG, PTEN, BRAF, PAX8, CALCA, NKX2-1
9MP:00030128.7PPARG, PIK3CA, PTTG1, PAX8, RET, NKX2-1
10MP:00107718.5PPARG, PIK3CA, PTEN, BRAF, CALCA, NRAS
11MP:00020068.4PPARG, PIK3CA, PTEN, BRAF, RET, CALCA
12MP:00028738.4PPARG, PTEN, BRAF, RET, CALCA, NRAS
13MP:00053978.3PPARG, PTTG1, PTEN, TG, BRAF, TSHR
14MP:00053808.2PTEN, PTTG1, PIK3CA, PPARG, BRAF, PAX8
15MP:00053678.2PPARG, PTTG1, PTEN, BRAF, PAX8, RET
16MP:00053858.1PAX8, BRAF, PTEN, PIK3CA, PPARG, RET
17MP:00053848.1PTEN, PTTG1, PIK3CA, PPARG, BRAF, PAX8
18MP:00053868.0BRAF, PTEN, PTTG1, PIK3CA, PPARG, TSHR
19MP:00053877.9BRAF, PTEN, PTTG1, PIK3CA, PPARG, TSHR
20MP:00053897.9PPARG, PIK3CA, PTTG1, PTEN, BRAF, PAX8
21MP:00053797.6HRAS, PPARG, PIK3CA, PTTG1, PTEN, TG
22MP:00036317.5BRAF, TG, PTEN, PTTG1, PIK3CA, PPARG
23MP:00053787.4BRAF, TG, PTEN, PTTG1, PIK3CA, PPARG
24MP:00107687.2PAX8, BRAF, PTEN, PTTG1, PIK3CA, PPARG
25MP:00053767.1PAX8, BRAF, TG, PTEN, PTTG1, PIK3CA

Publications for Thyroid Cancer

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Articles related to Thyroid Cancer:

(show top 50)    (show all 1661)
idTitleAuthorsYear
1
Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations. (25855579)
2015
2
Association of the miR-149 Rs2292832 Polymorphism with Papillary Thyroid Cancer Risk and Clinicopathologic Characteristics in a Chinese Population. (25405731)
2014
3
Commentary on: Implications of thyroglobulin antibody positivity in patients with differentiated thyroid cancer: a clinical position statement. (23987661)
2013
4
Evolving approaches to patients with advanced differentiated thyroid cancer. (23575762)
2013
5
Synoptic pathology reporting for thyroid cancer: a review and institutional experience. (24053206)
2013
6
Vandetanib: a novel targeted therapy for the treatment of metastatic or locally advanced medullary thyroid cancer. (23640345)
2013
7
High-Risk Patients with Differentiated Thyroid Cancer T4 Primary Tumors Achieve Remnant Ablation Equally Well Using rhTSH or Thyroid Hormone Withdrawal. (24040896)
2013
8
Differentiated thyroid cancer: indications and extent of central neck dissection--our experience. (24282633)
2013
9
Severe Hyponatremia Following Radioactive Iodine Therapy in Patients with Differentiated Thyroid Cancer. (24093878)
2013
10
Immunohistochemical detection of mutated BRAF V600E supports the clonal origin of BRAF-induced thyroid cancers along the spectrum of disease progression. (23775351)
2013
11
The current status of lymph node dissection in the treatment of papillary thyroid cancer. A literature review. (24045534)
2013
12
MK-2206 causes growth suppression and reduces neuroendocrine tumor marker production in medullary thyroid cancer through Akt inhibition. (23900743)
2013
13
Clinical behavior and genetics of nonsyndromic, familial nonmedullary thyroid cancer. (23652675)
2013
14
Marginal treatment benefit in anaplastic thyroid cancer. (23839797)
2013
15
Accidental discovery of lung metastases from differentiated thyroid cancer by 99mTc sodium pertechnetate scan in a patient with secondary hyperparathyroidism. (22889782)
2012
16
Incidental detection of hyperfunctioning thyroid cancer metastases in patients presenting with thyrotoxicosis. (22837931)
2012
17
BRAF(V600E) mutation in Turkish patients with papillary thyroid cancer: strong correlation with indicators of tumor aggressiveness. (22426956)
2012
18
Extended RET gene analysis in patients with apparently sporadic medullary thyroid cancer: clinical benefits and cost. (22648435)
2012
19
Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer. (21826673)
2012
20
Rearranged anaplastic lymphoma kinase (ALK) gene in adult-onset papillary thyroid cancer amongst atomic bomb survivors. (23050789)
2012
21
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. (21606412)
2011
22
Current role of metaiodobenzylguanidine in the diagnosis of pheochromocytoma and medullary thyroid cancer. (21803186)
2011
23
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. (22105174)
2011
24
Germline RET sequence variation I852M and occult medullary thyroid cancer: harmless polymorphism or causative mutation? (21711375)
2011
25
Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. (20371662)
2010
26
Thyroid cancers amongst goiter population in a Nigerian tertiary hospital: surgical and radiographic perspective. (21526634)
2010
27
The mitogen-activated protein kinase (MAPK) signaling pathway in papillary thyroid cancer. From the molecular bases to clinical practice]. (19627734)
2009
28
Follicular thyroid cancer cell growth inhibition by proteosome inhibitor MG132. (19552924)
2009
29
Medullary thyroid cancer: molecular biology and novel molecular therapies. (19468197)
2009
30
Ablative free thyroxine to thyroglobulin ratio as a predictor of differentiated thyroid cancer recurrence. (19769825)
2009
31
Genetic aspects of familial thyroid cancer. (19465682)
2009
32
The follow-up of patients with differentiated thyroid cancer and undetectable thyroglobulin (Tg) and Tg antibodies during ablation. (18166820)
2008
33
Fluorodeoxyglucose PET/CT in patients with differentiated thyroid cancer and elevated thyroglobulin after total thyroidectomy and (131)I ablation. (17538522)
2008
34
Dysregulated RET signaling in thyroid cancer. (18502331)
2008
35
Predicting the development of Cushing's syndrome in medullary thyroid cancer: utility of proopiomelanocortin messenger ribonucleic acid in situ hybridization. (17696832)
2007
36
Normocalcemic, subclinical, asymptomatic primary hyperparathyroidism in patients with goiter or papillary thyroid cancer--preliminary report. Normocalcemic primary hyperparathyroidism and thyroid pathology. (17966885)
2007
37
Positive predictive value of detectable stimulated tg during the first year after therapy of thyroid cancer and the value of comparison with Tg-ablation and Tg measured after 24 months. (17123341)
2006
38
Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer. (16263812)
2006
39
Risk of thyroid cancer after childhood exposure to ionizing radiation for tinea capitis. (17018661)
2006
40
Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. (15767343)
2005
41
Increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer. (16189643)
2005
42
Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. (15743786)
2005
43
Papillary thyroid cancer with chest metastases only detected using radioactive iodine. (15605906)
2004
44
Treatment of iodine-negative thyroglobulin-positive thyroid cancer: differences in outcome in patients with macrometastases and patients with micrometastases. (15232654)
2004
45
Procedure guidelines for radioiodine therapy of differentiated thyroid cancer (version 2)]. (15316577)
2004
46
Pulmonary epithelioid hemangioendothelioma coexistent with pulmonary metastasis of thyroid cancer. (11518122)
2001
47
Treating the patient with differentiated thyroid cancer with thyroglobulin-positive iodine-131 diagnostic scan-negative metastases: including comments on the role of serum thyroglobulin monitoring in tumor surveillance. (10787191)
2000
48
18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography localizes residual thyroid cancer in patients with negative diagnostic (131)I whole body scans and elevated serum thyroglobulin levels. (10404792)
1999
49
A case of follicular thyroid cancer with tracheal stenosis responded to external radiation therapy. (10378657)
1999
50
Infrequent CDKN2 mutation in human differentiated thyroid cancers. (8561866)
1996

Variations for Thyroid Cancer

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Expression for genes affiliated with Thyroid Cancer

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Search GEO for disease gene expression data for Thyroid Cancer.

Pathways for genes affiliated with Thyroid Cancer

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Pathways related to Thyroid Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 92)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
EGFR-dependent Endothelin signaling events36
9.9HRAS, EGF, NRAS
2
Show member pathways
9.9HRAS, EGF, NRAS
39.9HRAS, RET, PIK3CA
49.9EGF, HRAS, PIK3CA
5
Show member pathways
9.9HRAS, NRAS, BRAF
69.8PIK3CA, BRAF, HRAS
7
Show member pathways
9.7NRAS, PIK3CA, HRAS, EGF
8
Show member pathways
9.7NRAS, HRAS, BRAF, PIK3CA
99.7NRAS, HRAS, PIK3CA, BRAF
10
Show member pathways
9.7HRAS, EGF, NRAS, BRAF
11
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.7HRAS, CDKN1A, PTEN, PIK3CA
12
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells58
Oncostatin M Signaling Pathway36
9.6PPARG, NRAS, HRAS, BRAF
139.6PTEN, BRAF, CDKN1A, HRAS
149.5EGF, RASSF1, BRAF, PIK3CA
159.5PAX8, BRAF, PIK3CA, HRAS
16
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.5CDKN1A, HRAS, PIK3CA, PTEN, NRAS
17
Show member pathways
9.5BRAF, HRAS, RET, NRAS, PIK3CA
18
Show member pathways
9.5NRAS, PIK3CA, EGF, HRAS, BRAF
19
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
9.5NRAS, PIK3CA, PTEN, BRAF, HRAS
20
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.5PTEN, HRAS, CDKN1A, EGF, PIK3CA
21
Show member pathways
9.4HRAS, EGF, NRAS, BRAF, PTEN
22
Show member pathways
9.4NRAS, HRAS, PIK3CA, CDKN1A, BRAF
239.4HRAS, BRAF, NRAS, CDKN1A, PIK3CA
24
Show member pathways
9.4NRAS, PIK3CA, PPARG, BRAF, HRAS
25
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.4HRAS, PTEN, PIK3CA, BRAF, CDKN1A
269.3PTTG1, PIK3CA, NRAS, CDKN1A, HRAS
279.3PTEN, HRAS, EGF, CDKN1A, NRAS, PIK3CA
28
Show member pathways
9.3CDKN1A, PTEN, HRAS, EGF, NRAS, PIK3CA
29
Show member pathways
9.3PIK3CA, PTEN, NRAS, HRAS, CDKN1A, EGF
30
Show member pathways
9.3EGF, HRAS, CDKN1A, PIK3CA, PTEN, NRAS
31
Show member pathways
Development ERBB family signaling58
Development GDNF family signaling58
9.3NRAS, HRAS, RET, BRAF, PIK3CA, EGF
32
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
9.2EGF, HRAS, NRAS, BRAF, PTEN, PIK3CA
33
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.2PIK3CA, BRAF, NRAS, EGF, HRAS, PTEN
349.2EGF, PIK3CA, PTTG1, PTEN, CDKN1A
359.2NRAS, RASSF1, CDKN1A, HRAS, PTEN, PIK3CA
369.2PIK3CA, CDKN1A, HRAS, BRAF, EGF, NRAS
37
Show member pathways
9.2PIK3CA, BRAF, NRAS, CDKN1A, HRAS, EGF
38
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.2PIK3CA, EGF, BRAF, NRAS, HRAS, CDKN1A
399.2EGF, CDKN1A, NRAS, BRAF, PTEN, HRAS
40
Show member pathways
9.2PIK3CA, HRAS, BRAF, NRAS, EGF, RASSF1
41
Show member pathways
9.2BRAF, PPARG, PTEN, NRAS, EGF, HRAS
429.1BRAF, HRAS, NRAS, RET, PAX8, PPARG
43
Show member pathways
Signal transduction PTEN pathway58
9.0PIK3CA, HRAS, EGF, CDKN1A, NRAS, BRAF
44
Show member pathways
9.0BRAF, HRAS, EGF, CDKN1A, NRAS, PTEN
45
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
9.0PTEN, PIK3CA, BRAF, NRAS, CDKN1A, HRAS
46
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
9.0PIK3CA, PPARG, PTEN, BRAF, NRAS, EGF
47
Show member pathways
Signaling Pathways in Glioblastoma36
8.8PTEN, NRAS, PIK3CA, EGF, CDKN1A, BRAF
488.7HRAS, PTEN, PIK3CA, BRAF, CALCA, NRAS
49
Show member pathways
8.2KISS1R, HRAS, EGF, PIK3CA, CDKN1A, PTEN
508.0RET, PPARG, HRAS, EGF, CDKN1A, RASSF1

Compounds for genes affiliated with Thyroid Cancer

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Compounds related to Thyroid Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1panitumumab43 49 1212.1EGF, BRAF, PTEN
2phenylacetate4310.1HRAS, CDKN1A, PPARG
3mithramycin439.9CDKN1A, PPARG, CALCA
4iodine43 2410.8BRAF, TSHR, TG
5gefitinib43 49 1211.8CDKN1A, EGF, PIK3CA, PTEN
6crcs439.8PTEN, HRAS, RASSF1, BRAF, PIK3CA
7gemcitabine43 49 1211.8PTEN, CDKN1A, EGF, HRAS
8rosiglitazone28 43 49 24 1213.8PPARG, TSHR, CDKN1A, PIK3CA, PTEN
9imatinib43 49 1211.7CDKN1A, PIK3CA, PTEN, BRAF, RET
10phosphotyrosine439.7RET, PIK3CA, HRAS, PTEN, EGF
11lovastatin43 49 59 28 1213.7PTEN, CDKN1A, EGF, HRAS
12calcitriol43 59 24 1212.6EGF, CDKN1A, CALCA, PTEN, TG
13sodium iodide439.6TG, BRAF, PAX8, TSHR, RET, NKX2-1
14thyroxine43 2410.6TG, PAX8, CALCA, TSHR, PPARG
15iodide43 2410.6PIK3CA, TG, BRAF, PAX8, TSHR, NKX2-1
1612-o-tetradecanoylphorbol 13-acetate439.6HRAS, CDKN1A, TSHR, BRAF, RET, EGF
17phosphoinositide439.5BRAF, TSHR, EGF, HRAS, PIK3CA, PTEN
18paclitaxel43 49 1211.5CDKN1A, HRAS, BRAF, PTEN, PIK3CA, EGF
19methionine439.5HRAS, PTEN, TSHR, RET, RASSF1
20aspartate439.5TSHR, PTEN, BRAF, HRAS, TG, RET
21ribonucleic acid439.4TG, PTTG1, RET, PAX8, NKX2-1, TSHR
22pge2439.4PTEN, CALCA, PPARG, CDKN1A, EGF, HRAS
23adenylate439.4CALCA, EGF, TSHR, TG, PIK3CA, HRAS
24pd 98,059439.4HRAS, CDKN1A, BRAF, PTEN, PIK3CA, RET
25wortmannin439.4PIK3CA, EGF, PTEN, CDKN1A, RET, BRAF
26sodium43 2410.4PAX8, TSHR, NKX2-1, HRAS, TG, PIK3CA
27forskolin43 49 1211.4CALCA, TSHR, BRAF, EGF, PAX8, NKX2-1
28rapamycin439.3PIK3CA, EGF, CDKN1A, BRAF, PPARG, PTEN
29arginine439.3TSHR, RET, TG, BRAF, PIK3CA, HRAS
30thymidine43 2410.3HRAS, TSHR, TG, PTTG1, EGF, PIK3CA
31paraffin439.3PTEN, TG, BRAF, RET, CDKN1A, TSHR
32testosterone43 59 24 1212.3PIK3CA, CALCA, PTEN, EGF, RET, TG
33genistein43 28 59 2 24 1214.3EGF, CDKN1A, PTEN, PPARG, PIK3CA, TG
34progesterone43 28 59 24 1213.2CDKN1A, PTEN, HRAS, PIK3CA, BRAF, TSHR
35cyclic amp43 2410.2HRAS, NKX2-1, TSHR, CALCA, RET, EGF
36ly294002439.2RET, PIK3CA, HRAS, EGF, CDKN1A, PTEN
37cisplatin43 49 59 1212.2EGF, PIK3CA, PTEN, HRAS, BRAF, TG
38phosphatidylinositol439.1PIK3CA, PTTG1, PTEN, BRAF, TSHR, RET
39alanine439.0PPARG, KISS1R, RASSF1, RET, TSHR, BRAF
40h2o2439.0PIK3CA, PTEN, TG, CDKN1A, EGF, HRAS
41cysteine438.9TG, TSHR, PTTG1, PTEN, RET, EGF
42oligonucleotide438.7RASSF1, PTEN, BRAF, PAX8, TSHR, RET
43threonine438.5RET, PTEN, BRAF, PAX8, TSHR, HRAS
44agar438.5HRAS, CDKN1A, RASSF1, NRAS, RET, BRAF
45tyrosine438.4BRAF, TG, HRAS, PTEN, TSHR, RET
46retinoic acid43 249.4EGF, CDKN1A, RASSF1, NKX2-1, TSHR, PIK3CA
47calcium43 49 24 1211.4CALCA, KISS1R, PTEN, EGF, HRAS, PIK3CA
48serine438.3HRAS, BRAF, TG, CDKN1A, RASSF1, NKX2-1
49vegf438.2PIK3CA, PTTG1, HRAS, PTEN, TSHR, PPARG
50estrogen438.0PPARG, BRAF, HRAS, EGF, PIK3CA, PTTG1

GO Terms for genes affiliated with Thyroid Cancer

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Cellular components related to Thyroid Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058868.5PTEN, BRAF, TSHR, NRAS, RASSF1, KISS1R
2cytosolGO:00058298.1HRAS, NNMT, PPARG, PIK3CA, PTTG1, PTEN

Biological processes related to Thyroid Cancer according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Rac protein signal transductionGO:003502210.3NRAS, HRAS
2regulation of synaptic transmission, GABAergicGO:003222810.3HRAS, NRAS
3thyroid-stimulating hormone signaling pathwayGO:003819410.3PAX8, TSHR
4thyroid gland developmentGO:003087810.1NKX2-1, PAX8, TG
5positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:0200006010.1PTEN, EGF
6MAPK cascadeGO:000016510.1RET, NRAS, HRAS
7endothelial cell migrationGO:004354210.1PIK3CA, PTEN, CALCA
8striated muscle cell differentiationGO:005114610.0HRAS, NRAS
9response to arsenic-containing substanceGO:004668510.0PTEN, CDKN1A
10Ras protein signal transductionGO:000726510.0NRAS, RASSF1, CDKN1A, HRAS
11negative regulation of neuron apoptotic processGO:004352410.0HRAS, NRAS, BRAF, PIK3CA
12leukocyte migrationGO:00509009.9HRAS, NRAS, PIK3CA
13phosphatidylinositol-mediated signalingGO:00480159.9EGF, CDKN1A, PTEN, PIK3CA
14organ regenerationGO:00311009.8NNMT, PPARG, CDKN1A
15positive regulation of cell proliferationGO:00082849.8HRAS, EGF, NRAS, TSHR, PTEN
16activation of MAPKK activityGO:00001869.7BRAF, NRAS, KISS1R, EGF, HRAS
17negative regulation of cell proliferationGO:00082859.7PTEN, RNF139, KISS1R, CDKN1A, HRAS
18Fc-epsilon receptor signaling pathwayGO:00380959.6PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
19epidermal growth factor receptor signaling pathwayGO:00071739.6PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
20positive regulation of transcription, DNA-templatedGO:00458939.5EGF, NKX2-1, RET, PAX8, PPARG
21response to drugGO:00424939.5NNMT, PPARG, PTEN, RET, CDKN1A
22fibroblast growth factor receptor signaling pathwayGO:00085439.4HRAS, PIK3CA, PTEN, BRAF, NRAS, CDKN1A
23innate immune responseGO:00450879.4PPARG, PIK3CA, PTEN, NRAS, CDKN1A, EGF
24neurotrophin TRK receptor signaling pathwayGO:00480119.4PIK3CA, PTEN, BRAF, NRAS, CDKN1A, EGF
25protein phosphorylationGO:00064689.2BRAF, RET, CALCA, CDKN1A

Molecular functions related to Thyroid Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid-stimulating hormone receptor activityGO:000499610.0PAX8, TSHR
2protein bindingGO:00055156.4PPARG, PIK3CA, PTTG1, PTEN, BRAF, PAX8

Products for genes affiliated with Thyroid Cancer

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Sources for Thyroid Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet