MCID: THY028
MIFTS: 76

Thyroid Cancer malady

Cancer diseases, Endocrine diseases categories

Summaries for Thyroid Cancer

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it makes hormones that help the body work normally. there are several types of cancer of the thyroid gland. you are at greater risk if you are between ages 25 and 65 are a woman are asian have a family member who has had thyroid disease have had radiation treatments to your head or neck you should see a doctor if you have a lump or swelling in your neck. doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose thyroid cancer. treatment depends on the type of cancer you have and how far the cancer has spread. many patients receive a combination of treatments. they may include surgery, radioactive iodine, hormone treatment, radiation therapy, chemotherapy, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Thyroid Cancer, also known as thyroid carcinoma, is related to thyroiditis and goiter. An important gene associated with Thyroid Cancer is NKX2-1 (NK2 homeobox 1), and among its related pathways are Signaling by GPCR and Pathways in cancer. The drugs interferon alfa-2b and thyroglobulin and the compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include the thryoid gl, thyroid and testes, and related mouse phenotypes are growth/size and mortality/aging.

Disease Ontology:8 An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.

Wikipedia:63 Thyroid cancer is a malignant neoplasm originating from follicular or parafollicular thyroid cells. more...

Aliases & Classifications for Thyroid Cancer

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

thyroid cancer 8 10 44 33
thyroid carcinoma 8 44 60
thyroid neoplasm 8 60
malignant neoplasm of thyroid gland 8
malignant tumour of thyroid gland 8
head and neck cancer, thyroid 8
malignant neoplasm of thyroid 60
neoplasm of thyroid gland 8
thyroid gland neoplasm 8


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Disease Ontology8 DOID:1781, DOID:3963
ICD9CM27 193
NCIt39 C7510, C4815
MeSH34 D013964
ICD1025 C73

Related Diseases for Thyroid Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Thyroid Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 364)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis32.2CALCA, TSHR, TG
2goiter31.0TG, TSHR, PAX8, BRAF, CALCA, NKX2-1
3papillary thyroid carcinoma30.9EGF, CDKN1A, RET, KISS1R, RASSF1, PAX8
4cervical cancer30.8PIK3CA, EGF, CDKN1A, RASSF1
5papillary carcinoma30.8BRAF, CALCA, PPARG, NKX2-1, RET, HRAS
6graves' disease30.7NKX2-1, PAX8, TSHR, TG
7squamous cell carcinoma30.6PIK3CA, EGF, NKX2-1, CDKN1A, HRAS, RASSF1
8multinodular goiter30.6CALCA, TSHR, TG
9follicular thyroid carcinoma30.6BRAF, CALCA, PPARG, NKX2-1, RET, PAX8
10nodular goiter30.6BRAF, CALCA, RET, HRAS, TSHR, TG
11hyperthyroidism30.5TSHR, TG
12thyroid medullary carcinoma30.5BRAF, CALCA, NKX2-1, RET, TG
13struma ovarii30.5NKX2-1, TSHR, TG
14adenoma30.5BRAF, CALCA, PPARG, NKX2-1, NRAS, CDKN1A
15lung cancer30.4PPARG, PIK3CA, EGF, NKX2-1, CDKN1A, HRAS
16hyperparathyroidism30.4RET, CALCA
17adenocarcinoma30.4BRAF, PIK3CA, EGF, NKX2-1, CDKN1A, HRAS
18breast cancer30.4PIK3CA, EGF, NKX2-1, CDKN1A, RASSF1, PTEN
19familial adenomatous polyposis30.4BRAF, PPARG, NRAS, RASSF1
20thyroid carcinoma, follicular, somatic30.4HRAS, PTEN
21endemic goiter30.4TSHR, TG
22autoimmune thyroiditis30.4TG
23retinoblastoma30.3PPARG, PIK3CA, EGF, CDKN1A, HRAS, RASSF1
24thyroid cancer, anaplastic30.3BRAF, CALCA, PPARG, PIK3CA, EGF, NKX2-1
25pituitary adenoma30.3PTTG1, RET, PPARG
26melanoma30.3BRAF, PIK3CA, NKX2-1, NRAS, CDKN1A, HRAS
27phaeochromocytoma30.3RET, CALCA
28hypothyroidism30.3NKX2-1, TSHR, TG
29thyrotoxicosis30.3TG, TSHR
30obesity30.3PPARG
31lung adenocarcinoma30.3BRAF, PIK3CA, EGF, NKX2-1, CDKN1A, HRAS
32ovarian cancer30.3BRAF, PIK3CA, EGF, NKX2-1, CDKN1A, RASSF1
33leukemia30.3PIK3CA, EGF, NRAS, CDKN1A, HRAS, PTTG1
34paraganglioma30.2TG, RET, CALCA
35colorectal cancer30.2BRAF, PPARG, PIK3CA, EGF, NRAS, CDKN1A
36thymoma30.2NKX2-1
37neuroendocrine tumor30.2CALCA, NKX2-1, RET, RASSF1, PAX8
38sarcoma30.2HRAS, NRAS, BRAF
39familial medullary thyroid carcinoma30.2CALCA, RET
40nontoxic goiter30.2TSHR, TG
41pancreatic cancer30.0BRAF, PPARG, PIK3CA, EGF, NRAS, CDKN1A
42pancreatitis30.0NRAS, HRAS
43acute leukemia30.0PIK3CA, HRAS
44hemangioma30.0NKX2-1, RET
45parathyroid adenoma30.0RET, CALCA
46myxedema29.8TG, TSHR
47hepatocellular carcinoma29.8PIK3CA, NKX2-1, CDKN1A, HRAS, KISS1R, RASSF1
48astrocytoma29.8PIK3CA, EGF, CDKN1A, HRAS, RASSF1, PTEN
49lung small cell carcinoma29.8CALCA, PIK3CA, NKX2-1, RASSF1
50follicular adenoma29.8BRAF, CALCA, PPARG, NKX2-1, RET, HRAS

Graphical network of the top 20 diseases related to Thyroid Cancer:



Diseases related to thyroid cancer

Clinical Features for Thyroid Cancer

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Drugs & Therapeutics for Thyroid Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Thyroid Cancer

Drug clinical trials:

Search ClinicalTrials for Thyroid Cancer

Search NIH Clinical Center for Thyroid Cancer

Search CenterWatch for Thyroid Cancer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Thyroid Cancer

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Anatomical Context for Thyroid Cancer

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Thyroid Cancer:

32
Thyroid, Testes, Lymph node, Breast, Lung, Endothelial, Bone, Pituitary, Colon, T cells, Salivary gland, Skin, Ovary, Pancreas, Cervix, Prostate, Myeloid, Testis, Brain, Liver, Thymus, Nk cells, Appendix

FMA organs/tissues related to Thyroid Cancer:

14
The thryoid gl

Animal Models for Thyroid Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thyroid Cancer:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537812.9NRAS, NKX2-1, EGF, PIK3CA, PPARG, BRAF
2MP:001076812.9BRAF, CALCA, PPARG, PIK3CA, NKX2-1, NRAS
3MP:000538512.5BRAF, CALCA, PPARG, PIK3CA, NKX2-1, NRAS
4MP:000538612.4NKX2-1, PIK3CA, PPARG, CALCA, BRAF, CDKN1A
5MP:000538712.4BRAF, PPARG, PIK3CA, EGF, NRAS, CDKN1A
6MP:000200612.4BRAF, CALCA, PPARG, PIK3CA, NKX2-1, NRAS
7MP:000538412.4NRAS, NKX2-1, PIK3CA, PPARG, BRAF, CDKN1A
8MP:000537912.2TG, PIK3CA, EGF, CDKN1A, RET, HRAS
9MP:000363112.2PPARG, NKX2-1, CDKN1A, RET, HRAS, KISS1R
10MP:000287312.1BRAF, CALCA, PPARG, EGF, NRAS, RET
11MP:000538912.1BRAF, PIK3CA, EGF, CDKN1A, RET, PAX8
12MP:000539712.0BRAF, PPARG, NRAS, CDKN1A, RET, KISS1R
13MP:000301212.0PPARG, PIK3CA, NKX2-1, NRAS, CDKN1A, RET
14MP:000537611.9CALCA, PIK3CA, NRAS, RET, KISS1R, PAX8
15MP:000538111.8BRAF, EGF, NKX2-1, NRAS, CDKN1A, RET
16MP:001077111.7CALCA, PIK3CA, NRAS, CDKN1A, HRAS, KISS1R
17MP:000536711.5PPARG, RET, KISS1R, PAX8, PTTG1
18MP:000537011.3PPARG, NRAS, CDKN1A, KISS1R, PTEN, BRAF
19MP:000538011.3PPARG, RET, PAX8, PTTG1
20MP:000539011.1NKX2-1, CDKN1A, HRAS, PAX8
21MP:000538810.8CDKN1A, PTEN
22MP:000537510.7PTTG1
23MP:000539110.7EGF, PPARG
24MP:000537710.5TSHR, PAX8

Publications for Thyroid Cancer

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50PubMed
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Articles related to Thyroid Cancer:

(show top 50)    (show all 1764)
idTitleAuthorsYear
1
(131)I treatment for thyroid cancer and risk of developing primary hyperparathyroidism: a cohort study. (23982456)
2014
2
Vandetanib: a novel targeted therapy for the treatment of metastatic or locally advanced medullary thyroid cancer. (23640345)
2013
3
Clinical behavior and genetics of nonsyndromic, familial nonmedullary thyroid cancer. (23652675)
2013
4
Patterns of Structural Recurrence in Papillary Thyroid Cancer. (24149717)
2013
5
Metastasis of thyroid cancer to the sternum after total thyroidectomy and laryngectomy. (24159407)
2013
6
Clinicopathologic characteristics of synchronous primary thyroid cancer detected by initial staging 18F-FDG PET-CT examination in patients with underlying malignancy. (23510334)
2013
7
Metastatic squamous cell carcinoma thyroid from functionally cured cancer cervix. (24163519)
2013
8
Regulatory T cells and plasmacytoid dendritic cells contribute to the immune escape of papillary thyroid cancer coexisting with multinodular non-toxic goiter. (23264145)
2013
9
Risk of thyroid cancer in first-degree relatives of patients with non-medullary thyroid cancer by histology type and age at diagnosis: a joint study from five Nordic countries. (23585692)
2013
10
Incidental finding on a SPECT/CT of a retroperitoneal leiomyosarcoma imitating a hiatal hernia in 131I whole-body scan in thyroid cancer evaluation. (23850374)
2013
11
Is routine prophylactic central neck dissection indicated for low-risk papillary thyroid cancer: can we determine cost-effectiveness if we are unsure about its effectiveness and safety? (24238040)
2013
12
Re: "Sleep disturbance and incidence of thyroid cancer in postmenopausal women. the Women's Health Initiative". (23897646)
2013
13
Managing newly diagnosed thyroid cancer. (24101616)
2013
14
A rare case of laryngotracheal chondrosarcoma in a patient with past history of radioiodine therapy for thyroid cancer. (24223389)
2013
15
Optimal Timing of Surgery for Differentiated Thyroid Cancer in Pregnant Women. (24248429)
2013
16
Follicular variant of papillary thyroid cancer: encapsulated, nonencapsulated, and diffuse: distinct biologic and clinical entities. (22431868)
2012
17
Comparison of the expression levels of napsin A, thyroid transcription factor-1, and p63 in nonsmall cell lung cancer using cytocentrifuged bronchial brushings. (21717589)
2011
18
Treatment results and prognostic factors in primary thyroid lymphoma patients: a rare cancer network study. (20587509)
2011
19
Thyroglobulin and anti-thyroglobulin assays in thyroid cancer monitoring. (19154731)
2009
20
Knockdown of IG20 gene expression renders thyroid cancer cells susceptible to apoptosis. (19190106)
2009
21
Anti-tumoral effect of a celecoxib low dose on a model of human medullary thyroid cancer in nude mice. (19281427)
2009
22
Galectin-3 in diagnosis of thyroid cancer]. (18652236)
2008
23
Case-control study of anaplastic thyroid cancer: goiter patients as controls. (18287867)
2008
24
C8orf4/TC-1 (thyroid cancer-1) gene expression in thyroid cancer and goiter. (17167272)
2007
25
99mTc-sestamibi radio-guided surgery of loco-regional 131Iodine-negative recurrent thyroid cancer. (17267163)
2007
26
Patients treated for differentiated thyroid cancer with negative 131I whole-body scans and elevated thyroglobulin levels: a possible course]. (17524307)
2007
27
Sensitivity of [99mTc]methoxyisobutylisonitrile scan in patients with metastatic differentiated thyroid cancer. (17473819)
2007
28
Clinical implications of pre-operative rapid BRAF analysis for papillary thyroid cancer. (17429154)
2007
29
Paneling human thyroid cancer cell lines for candidate proteins for targeted anti-angiogenic therapy. (16475167)
2006
30
High incidence of thyroid cancer in long-standing goiters with thyroglobulin mutations. (16187918)
2005
31
Altered expression of cyclins and cell cycle inhibitors in papillary thyroid cancer: prognostic implications. (15929668)
2005
32
Recombinant human thyrotropin is helpful in the follow-up and 131I therapy of patients with thyroid cancer: a report of the results and benefits using recombinant human thyrotropin in clinical routine. (15876162)
2005
33
FDG-PET in head and neck, and thyroid cancer. (16086543)
2005
34
Controversies in the follow-up and management of well-differentiated thyroid cancer. (15027888)
2004
35
Clinical behavior and outcome of papillary thyroid cancers smaller than 1.5 cm in diameter: study of 299 cases. (15292295)
2004
36
Projecting the time trend of thyroid cancers: its impact on assessment of radiation-induced cancer risks. (15545767)
2004
37
Characterization of a thyroid hormone-mediated short-loop feedback control of TSH receptor gene in an anaplastic human thyroid cancer cell line. (12429043)
2002
38
Clinical impact of retinoids in redifferentiation therapy of advanced thyroid cancer: final results of a pilot study. (12029551)
2002
39
Two unusual sites of colon cancer metastases and a rare thyroid lymphoma. Case 2. Chemotherapy-responsive right artial metastasis from colon carcinoma. (11481366)
2001
40
Double primary cancers of the breast and thyroid in women: molecular analysis and genetic implications. (14574011)
2001
41
Transcriptional activation of the thyroglobulin promoter directing suicide gene expression by thyroid transcription factor-1 in thyroid cancer cells. (11325833)
2001
42
Thyroid cancer. (11165748)
2001
43
From amplification to gene in thyroid cancer: a high-resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization. (9683604)
1998
44
Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer. (8770310)
1996
45
Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1. (8751579)
1996
46
Analysis of the RET gene and medullary cancer of the thyroid. Contribution to the diagnosis and treatment]. (8734283)
1996
47
Is residence in areas of endemic goiter a risk factor for thyroid cancer? (7768633)
1995
48
Thyroid cancer after radiotherapy for skin hemangioma in infancy. (7972685)
1994
49
Serum thyroglobulin measurements in thyroid cancer: evaluation of 'false' positive results. (1769134)
1991
50
An autopsy case of primary multiple tumor (remarkable diffuse adenomyomatosis uteri combined with cancer of portio vaginalis, adenoma of thyroid gland and mucocele of appendix) [Japanese text]. (14906566)
1951

Genetic Variations for Thyroid Cancer

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Expression for genes affiliated with Thyroid Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroid Cancer

Search GEO for disease gene expression data for Thyroid Cancer.

Pathways for genes affiliated with Thyroid Cancer

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Sources:
53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 49PharmGKB, 59Tocris Bioscience, 52R&D Systems
See all sources

Pathways related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.9NRAS, EGF, BRAF, PTEN, CALCA, PIK3CA
211.7CDKN1A, BRAF, PPARG, PIK3CA, EGF, NRAS
3
Hide members
11.5HRAS, NRAS, CDKN1A, EGF, PTEN, PIK3CA
411.3CDKN1A, NRAS, PIK3CA, HRAS, PTEN, RASSF1
5
Hide members
11.3PIK3CA, EGF, CDKN1A, PTEN, HRAS, NRAS
6
Hide members
11.3NRAS, PIK3CA, CDKN1A, EGF, HRAS, PTEN
711.3HRAS, PTEN, EGF, NRAS, PIK3CA, CDKN1A
811.3PTEN, HRAS, NRAS, PIK3CA, EGF, CDKN1A
9
Hide members
11.3PIK3CA, CDKN1A, HRAS, PTEN, EGF, NRAS
10
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11.3PIK3CA, EGF, PTEN, HRAS, NRAS, BRAF
11
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11.3PIK3CA, EGF, NRAS, HRAS, PTEN, BRAF
12
Translation Insulin regulation of translation
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11.3HRAS, NRAS, EGF, PTEN, PIK3CA, BRAF
13
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11.3BRAF, EGF, CDKN1A, HRAS, NRAS, PIK3CA
14
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11.3NRAS, BRAF, EGF, CDKN1A, HRAS, PIK3CA
1511.3EGF, BRAF, PIK3CA, NRAS, HRAS, CDKN1A
16
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11.3PTEN, HRAS, NRAS, EGF, PPARG, BRAF
1711.3HRAS, CDKN1A, EGF, BRAF, NRAS, PTEN
18
Hide members
11.3PIK3CA, BRAF, HRAS, EGF, NRAS, RET
1911.3RET, PAX8, BRAF, PPARG, NRAS, HRAS
20
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11.2NRAS, PIK3CA, CDKN1A, HRAS, PTEN
21
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11.2HRAS, BRAF, NRAS, EGF, PIK3CA
22
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11.2HRAS, BRAF, PIK3CA, NRAS, PTEN
23
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11.2BRAF, PTEN, HRAS, NRAS, EGF
24
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11.2HRAS, PIK3CA, NRAS, PPARG, BRAF
2511.2BRAF, NRAS, CDKN1A, HRAS, PIK3CA
26
Transcription Androgen Receptor nuclear signaling
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11.2EGF, PTEN, CDKN1A, PIK3CA, HRAS
27
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11.2PTEN, CDKN1A, PIK3CA, BRAF, HRAS
28
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11.2HRAS, RET, NRAS, PIK3CA, BRAF
2911.2PTTG1, PIK3CA, NRAS, CDKN1A, HRAS
3011.2CDKN1A, EGF, PIK3CA, PTEN, PTTG1
31
Hide members
11.0EGF, HRAS, PIK3CA, NRAS
32
Hide members
11.0EGF, HRAS, NRAS, PIK3CA
33
Hide members
11.0NRAS, EGF, HRAS, BRAF
34
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11.0BRAF, PTEN, HRAS, NRAS
35
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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11.0BRAF, PPARG, HRAS, NRAS
36
Development Ligand-independent activation of ESR1 and ESR2
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11.0PPARG, PIK3CA, EGF, HRAS
37
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11.0BRAF, CDKN1A, HRAS, NRAS
38
Hide members
11.0PIK3CA, HRAS, PTEN, CDKN1A
3911.0BRAF, EGF, RASSF1, PIK3CA
4011.0BRAF, CDKN1A, HRAS, PTEN
4111.0PIK3CA, BRAF, PAX8, HRAS
4210.9PIK3CA, NRAS, HRAS
43
Hide members
10.9HRAS, NRAS, PIK3CA
44
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10.9EGF, NRAS, HRAS
45
Hide members
10.9HRAS, NRAS, BRAF
46
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10.9BRAF, NRAS, HRAS
4710.9EGF, HRAS, PIK3CA
48
G-protein signaling Cross-talk between Ras-family GTPases
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10.9HRAS, PIK3CA, BRAF
4910.9RET, PIK3CA, HRAS
50
G-protein signaling H-RAS regulation pathway
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10.9HRAS, PIK3CA, RET

Compounds for genes affiliated with Thyroid Cancer

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1vegf4412.6PTTG1, PTEN, HRAS, CALCA, CDKN1A, EGF
2retinoic acid44 2413.6PIK3CA, TSHR, TG, RASSF1, HRAS, RET
3tyrosine4412.6HRAS, RET, NRAS, NKX2-1, TSHR, EGF
4agar4412.5RET, HRAS, PTEN, CDKN1A, NRAS, EGF
5threonine4412.5PIK3CA, BRAF, EGF, HRAS, TSHR, CDKN1A
6oligonucleotide4412.3BRAF, NKX2-1, NRAS, CDKN1A, RET, HRAS
7ly2940024412.0BRAF, PTEN, HRAS, RET, CDKN1A, EGF
8calcium44 49 11 2415.0PTTG1, HRAS, PTEN, RET, TSHR, KISS1R
9paraffin4412.0TG, BRAF, RET, HRAS, NKX2-1, TSHR
10genistein44 28 59 2 11 2417.0RET, CDKN1A, PTEN, HRAS, TG, EGF
11cisplatin44 49 59 1115.0TG, HRAS, RASSF1, PIK3CA, EGF, BRAF
12cyclic amp44 2413.0BRAF, CALCA, PTEN, TSHR, HRAS, RET
13progesterone44 59 28 11 2416.0NKX2-1, BRAF, PIK3CA, EGF, CDKN1A, HRAS
14phosphatidylinositol4412.0EGF, RET, PTTG1, TSHR, PIK3CA, BRAF
15alanine4411.9TG, PTEN, BRAF, TSHR, PPARG, KISS1R
16serine4411.9RASSF1, HRAS, RET, NKX2-1, PAX8, PIK3CA
17rapamycin4411.9PIK3CA, PPARG, BRAF, PTEN, HRAS, CDKN1A
18pd 98,0594411.9PIK3CA, EGF, CDKN1A, RET, BRAF, HRAS
19wortmannin4411.9EGF, PIK3CA, BRAF, CDKN1A, RET, PTEN
20thymidine44 2412.8PTTG1, PIK3CA, EGF, CDKN1A, HRAS, TSHR
21testosterone44 59 11 2414.8RET, TG, PTEN, EGF, PPARG, PIK3CA
22sodium iodide4411.8TSHR, PAX8, RET, NKX2-1, BRAF, TG
23arginine4411.7TSHR, PTEN, HRAS, PIK3CA, BRAF, RET
24ribonucleic acid4411.7TSHR, RET, PTTG1, NKX2-1, TG, PAX8
2512-o-tetradecanoylphorbol 13-acetate4411.7BRAF, CDKN1A, EGF, TSHR, HRAS, RET
26paclitaxel44 49 1113.7BRAF, PIK3CA, EGF, CDKN1A, HRAS, PTEN
27phosphoinositide4411.6TSHR, HRAS, PIK3CA, EGF, BRAF, PTEN
28forskolin44 49 1113.6EGF, CALCA, TSHR, PAX8, NKX2-1, BRAF
29iodide44 2412.6PAX8, BRAF, PIK3CA, NKX2-1, TG
30crcs4411.6PTEN, PIK3CA, RASSF1, HRAS, BRAF
31aspartate4411.6PTEN, HRAS, TG, RET, BRAF, TSHR
32rosiglitazone44 49 28 11 2415.5PIK3CA, CDKN1A, PTEN, TSHR, PPARG
33thyroxine44 2412.5TSHR, TG, PAX8, CALCA, PPARG
34imatinib44 49 1113.5BRAF, PIK3CA, CDKN1A, PTEN, RET
35calcitriol44 59 11 2414.5CDKN1A, CALCA, EGF, PTEN, TG
36phosphotyrosine4411.4EGF, PIK3CA, RET, HRAS, PTEN
37adenylate4411.4CALCA, PIK3CA, TG, TSHR, EGF, HRAS
38estrogen4411.3TG, TSHR, PTTG1
39h2o24411.3PTEN, EGF, CDKN1A, HRAS, TG, PIK3CA
40gefitinib44 49 1113.3PTEN, CDKN1A, EGF, PIK3CA
41panitumumab44 49 1113.3PTEN, EGF, BRAF
42gemcitabine44 49 1113.2CDKN1A, HRAS, EGF, PTEN
43phenylacetate4411.2HRAS, CDKN1A, PPARG
44pge24411.2HRAS, CDKN1A, PTEN
45lovastatin44 49 59 28 1115.1PTEN, CDKN1A, EGF, HRAS
46sodium44 2412.1TG, PAX8
47methionine4411.1HRAS, RASSF1, PTEN, TSHR, RET
48iodine44 2412.1TG, TSHR, BRAF
49manumycin4410.9CDKN1A, EGF, HRAS
50gf 109203x44 5911.7CDKN1A, HRAS, PPARG, EGF

GO Terms for genes affiliated with Thyroid Cancer

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Sources:
16Gene Ontology
See all sources

Biological processes related to Thyroid Cancer according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathwayGO:00854311.8PTEN, HRAS, CDKN1A, NRAS, EGF, PIK3CA
2neurotrophin TRK receptor signaling pathwayGO:04801111.8BRAF, PIK3CA, EGF, NRAS, CDKN1A, HRAS
3innate immune responseGO:04508711.7PPARG, PIK3CA, EGF, NRAS, CDKN1A, HRAS
4Fc-epsilon receptor signaling pathwayGO:03809511.6PIK3CA, EGF, NRAS, CDKN1A, HRAS, PTEN
5epidermal growth factor receptor signaling pathwayGO:00717311.6PIK3CA, EGF, NRAS, CDKN1A, HRAS, PTEN
6activation of MAPKK activityGO:00018611.5BRAF, EGF, NRAS, HRAS, KISS1R
7negative regulation of cell proliferationGO:00828511.4CDKN1A, RNF139, HRAS, KISS1R, PTEN
8Ras protein signal transductionGO:00726511.3NRAS, CDKN1A, HRAS, RASSF1
9positive regulation of cell proliferationGO:00828411.3EGF, NRAS, HRAS, PTEN, TSHR
10phosphatidylinositol-mediated signalingGO:04801511.2PIK3CA, EGF, CDKN1A, PTEN
11positive regulation of transcription, DNA-dependentGO:04589311.2PPARG, EGF, NKX2-1, RET, PAX8
12thyroid gland developmentGO:03087811.1TG, PAX8, NKX2-1
13endothelial cell migrationGO:04354211.1CALCA, PIK3CA, PTEN
14MAPK cascadeGO:00016511.0HRAS, RET, NRAS
15positive regulation of Rac protein signal transductionGO:03502210.9HRAS, NRAS
16positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.8PTEN, EGF
17regulation of synaptic transmission, GABAergicGO:03222810.7HRAS, NRAS
18striated muscle cell differentiationGO:05114610.5HRAS, NRAS

Molecular functions related to Thyroid Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.4TSHR, BRAF, CALCA, PPARG, PIK3CA, EGF
2thyroid-stimulating hormone receptor activityGO:00499610.8TSHR, PAX8

Products for genes affiliated with Thyroid Cancer

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Sources for Thyroid Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet