MCID: THY028
MIFTS: 76

Thyroid Cancer malady

Cancer diseases, Endocrine diseases categories

Summaries for Thyroid Cancer

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it makes hormones that help the body work normally. there are several types of cancer of the thyroid gland. you are at greater risk if you are between ages 25 and 65 are a woman are asian have a family member who has had thyroid disease have had radiation treatments to your head or neck you should see a doctor if you have a lump or swelling in your neck. doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose thyroid cancer. treatment depends on the type of cancer you have and how far the cancer has spread. many patients receive a combination of treatments. they may include surgery, radioactive iodine, hormone treatment, radiation therapy, chemotherapy, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Thyroid Cancer, also known as thyroid carcinoma, is related to thyroiditis and goiter. An important gene associated with Thyroid Cancer is NKX2-1 (NK2 homeobox 1), and among its related pathways are Signaling by GPCR and Pathways in cancer. The drugs interferon alfa-2b and thyroglobulin and the compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include the thryoid gl, thyroid and testes, and related mouse phenotypes are growth/size and mortality/aging.

Disease Ontology:8 An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.

Wikipedia:63 Thyroid cancer is a malignant neoplasm originating from follicular or parafollicular thyroid cells. more...

Aliases & Classifications for Thyroid Cancer

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

thyroid cancer 8 10 44 33
thyroid carcinoma 8 44 60
thyroid neoplasm 8 60
malignant neoplasm of thyroid gland 8
malignant tumour of thyroid gland 8
head and neck cancer, thyroid 8
malignant neoplasm of thyroid 60
neoplasm of thyroid gland 8
thyroid gland neoplasm 8


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Disease Ontology8 DOID:1781, DOID:3963
ICD9CM27 193
NCIt39 C7510, C4815
MeSH34 D013964
ICD1025 C73

Related Diseases for Thyroid Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Thyroid Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 364)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis32.2CALCA, TSHR, TG
2goiter31.0TG, TSHR, PAX8, BRAF, CALCA, NKX2-1
3papillary thyroid carcinoma30.9EGF, CDKN1A, RET, KISS1R, RASSF1, PAX8
4cervical cancer30.8PIK3CA, EGF, CDKN1A, RASSF1
5papillary carcinoma30.8BRAF, CALCA, PPARG, NKX2-1, RET, HRAS
6graves' disease30.7NKX2-1, PAX8, TSHR, TG
7squamous cell carcinoma30.6PIK3CA, EGF, NKX2-1, CDKN1A, HRAS, RASSF1
8multinodular goiter30.6CALCA, TSHR, TG
9follicular thyroid carcinoma30.6BRAF, CALCA, PPARG, NKX2-1, RET, PAX8
10nodular goiter30.6BRAF, CALCA, RET, HRAS, TSHR, TG
11hyperthyroidism30.5TSHR, TG
12thyroid medullary carcinoma30.5BRAF, CALCA, NKX2-1, RET, TG
13struma ovarii30.5NKX2-1, TSHR, TG
14adenoma30.5BRAF, CALCA, PPARG, NKX2-1, NRAS, CDKN1A
15lung cancer30.4PPARG, PIK3CA, EGF, NKX2-1, CDKN1A, HRAS
16hyperparathyroidism30.4RET, CALCA
17adenocarcinoma30.4BRAF, PIK3CA, EGF, NKX2-1, CDKN1A, HRAS
18breast cancer30.4PIK3CA, EGF, NKX2-1, CDKN1A, RASSF1, PTEN
19familial adenomatous polyposis30.4BRAF, PPARG, NRAS, RASSF1
20thyroid carcinoma, follicular, somatic30.4HRAS, PTEN
21endemic goiter30.4TSHR, TG
22autoimmune thyroiditis30.4TG
23retinoblastoma30.3PPARG, PIK3CA, EGF, CDKN1A, HRAS, RASSF1
24thyroid cancer, anaplastic30.3BRAF, CALCA, PPARG, PIK3CA, EGF, NKX2-1
25pituitary adenoma30.3PTTG1, RET, PPARG
26melanoma30.3BRAF, PIK3CA, NKX2-1, NRAS, CDKN1A, HRAS
27phaeochromocytoma30.3RET, CALCA
28hypothyroidism30.3NKX2-1, TSHR, TG
29thyrotoxicosis30.3TG, TSHR
30obesity30.3PPARG
31lung adenocarcinoma30.3BRAF, PIK3CA, EGF, NKX2-1, CDKN1A, HRAS
32ovarian cancer30.3BRAF, PIK3CA, EGF, NKX2-1, CDKN1A, RASSF1
33leukemia30.3PIK3CA, EGF, NRAS, CDKN1A, HRAS, PTTG1
34paraganglioma30.2TG, RET, CALCA
35colorectal cancer30.2BRAF, PPARG, PIK3CA, EGF, NRAS, CDKN1A
36thymoma30.2NKX2-1
37neuroendocrine tumor30.2CALCA, NKX2-1, RET, RASSF1, PAX8
38sarcoma30.2HRAS, NRAS, BRAF
39familial medullary thyroid carcinoma30.2CALCA, RET
40nontoxic goiter30.2TSHR, TG
41pancreatic cancer30.0BRAF, PPARG, PIK3CA, EGF, NRAS, CDKN1A
42pancreatitis30.0NRAS, HRAS
43acute leukemia30.0PIK3CA, HRAS
44hemangioma30.0NKX2-1, RET
45parathyroid adenoma30.0RET, CALCA
46myxedema29.8TG, TSHR
47hepatocellular carcinoma29.8PIK3CA, NKX2-1, CDKN1A, HRAS, KISS1R, RASSF1
48astrocytoma29.8PIK3CA, EGF, CDKN1A, HRAS, RASSF1, PTEN
49lung small cell carcinoma29.8CALCA, PIK3CA, NKX2-1, RASSF1
50follicular adenoma29.8BRAF, CALCA, PPARG, NKX2-1, RET, HRAS

Graphical network of the top 20 diseases related to Thyroid Cancer:



Diseases related to thyroid cancer

Clinical Features for Thyroid Cancer

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Drugs & Therapeutics for Thyroid Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Thyroid Cancer

Drug clinical trials:

Search ClinicalTrials for Thyroid Cancer

Search NIH Clinical Center for Thyroid Cancer

Search CenterWatch for Thyroid Cancer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Thyroid Cancer

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Anatomical Context for Thyroid Cancer

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Thyroid Cancer:

32
Thyroid, Testes, Lymph node, Breast, Lung, Endothelial, Bone, Pituitary, Colon, T cells, Salivary gland, Skin, Ovary, Pancreas, Cervix, Prostate, Myeloid, Testis, Brain, Liver, Thymus, Nk cells, Appendix

FMA organs/tissues related to Thyroid Cancer:

14
The thryoid gl

Animal Models for Thyroid Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thyroid Cancer:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537812.9NRAS, NKX2-1, EGF, PIK3CA, PPARG, BRAF
2MP:001076812.9BRAF, CALCA, PPARG, PIK3CA, NKX2-1, NRAS
3MP:000538512.5BRAF, CALCA, PPARG, PIK3CA, NKX2-1, NRAS
4MP:000538612.4NKX2-1, PIK3CA, PPARG, CALCA, BRAF, CDKN1A
5MP:000538712.4BRAF, PPARG, PIK3CA, EGF, NRAS, CDKN1A
6MP:000200612.4BRAF, CALCA, PPARG, PIK3CA, NKX2-1, NRAS
7MP:000538412.4NRAS, NKX2-1, PIK3CA, PPARG, BRAF, CDKN1A
8MP:000537912.2TG, PIK3CA, EGF, CDKN1A, RET, HRAS
9MP:000363112.2PPARG, NKX2-1, CDKN1A, RET, HRAS, KISS1R
10MP:000287312.1BRAF, CALCA, PPARG, EGF, NRAS, RET
11MP:000538912.1BRAF, PIK3CA, EGF, CDKN1A, RET, PAX8
12MP:000539712.0BRAF, PPARG, NRAS, CDKN1A, RET, KISS1R
13MP:000301212.0PPARG, PIK3CA, NKX2-1, NRAS, CDKN1A, RET
14MP:000537611.9CALCA, PIK3CA, NRAS, RET, KISS1R, PAX8
15MP:000538111.8BRAF, EGF, NKX2-1, NRAS, CDKN1A, RET
16MP:001077111.7CALCA, PIK3CA, NRAS, CDKN1A, HRAS, KISS1R
17MP:000536711.5PPARG, RET, KISS1R, PAX8, PTTG1
18MP:000537011.3PPARG, NRAS, CDKN1A, KISS1R, PTEN, BRAF
19MP:000538011.3PPARG, RET, PAX8, PTTG1
20MP:000539011.1NKX2-1, CDKN1A, HRAS, PAX8
21MP:000538810.8CDKN1A, PTEN
22MP:000537510.7PTTG1
23MP:000539110.7EGF, PPARG
24MP:000537710.5TSHR, PAX8

Publications for Thyroid Cancer

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50PubMed
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Articles related to Thyroid Cancer:

(show top 50)    (show all 1764)
idTitleAuthorsYear
1
Down-regulation of Thyroid Hormone Receptor I^1 Gene Expression in Gastric Cancer Involves Promoter Methylation. (24434154)
2014
2
Predictive factors of thyroid cancer in patients with graves' disease. (24166025)
2014
3
Notch pathway is activated by MAPK signaling and influences papillary thyroid cancer proliferation. (23544172)
2013
4
Lung uptake on I-131 therapy and short-term outcome in patients with lung metastasis from differentiated thyroid cancer. (24374647)
2013
5
The role of chemotherapy and latest emerging target therapies in anaplastic thyroid cancer. (24092989)
2013
6
The contributions of gamma probe to lesion detectability and surgical safety in recurrent thyroid cancer at risk. (24003398)
2013
7
Significant associations between X-ray repair cross-complementing group 3 genetic polymorphisms and thyroid cancer risk. (24277376)
2013
8
Graves' Disease that Developed Shortly after Surgery for Thyroid Cancer. (24396683)
2013
9
A long non-coding RNA, PTCSC3, as a tumor suppressor and a target of miRNAs in thyroid cancer cells. (23599737)
2013
10
Treatment of advanced medullary thyroid cancer. (23514632)
2013
11
DNA methylation signatures identify biologically distinct thyroid cancer subtypes. (23666970)
2013
12
Epidemiology of thyroid cancer in an area of epidemic thyroid goiter. (23533411)
2013
13
Iodine-131 in sewage sludge from a small water pollution control plant serving a thyroid cancer treatment facility. (23799495)
2013
14
Increased incidence of thyroid cancer in Latina, Italy: a possible role of detection of subclinical disease. (23518150)
2013
15
Approach to follow-up of the patient with differentiated thyroid cancer and positive anti-thyroglobulin antibodies. (23922347)
2013
16
Sorafenib in radioiodine-refractory differentiated thyroid cancer: a meta-analysis. (24302666)
2013
17
An hypothesis on the presumed association between thyroid goiter and gastric cancer. (23271410)
2013
18
Glucagon-Like Peptide-1 Receptor Imaging with [Lys (40) (Ahx-HYNIC- (99 m) Tc/EDDA)NH 2 ]-Exendin-4 for the Diagnosis of Recurrence or Dissemination of Medullary Thyroid Cancer: A Preliminary Report. (23606839)
2013
19
Is BRAF mutation associated with lymph node metastasis in patients with papillary thyroid cancer? (23062653)
2012
20
Optimal surgical management of well-differentiated thyroid cancer arising in struma ovarii: a series of 4 patients and a review of 53 reported cases. (22181336)
2012
21
The prevalence of thyroid cancer and benign thyroid disease in patients with familial adenomatous polyposis may be higher than previously recognized. (22425061)
2012
22
Current role of metaiodobenzylguanidine in the diagnosis of pheochromocytoma and medullary thyroid cancer. (21803186)
2011
23
Both BRAF V600E mutation and older age (a8Y 65 years) are associated with recurrent papillary thyroid cancer. (21594703)
2011
24
Screening for thyroid cancer in patients with familial adenomatous polyposis. (21173694)
2011
25
Evaluation of the PAX8/PPARG translocation in follicular thyroid cancer with a 4-color reverse-transcription PCR assay and automated high-resolution fragment analysis. (20056739)
2010
26
Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues. (19779036)
2010
27
Targeting vascular endothelial growth factor receptor in thyroid cancer: the intracellular and extracellular implications. (20103668)
2010
28
Thyroid cancer is the most common cancer associated with acromegaly. (20217483)
2010
29
Immunoanalysis indicates that the sodium iodide symporter is not overexpressed in intracellular compartments in thyroid and breast cancers. (19029227)
2009
30
Serum thyroglobulin measurement in the follow-up of patients treated for differentiated thyroid cancer. (19910901)
2009
31
Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer. (19825987)
2009
32
Galectin-3 regulates apoptosis and doxorubicin chemoresistance in papillary thyroid cancer cells. (19124005)
2009
33
Identification of differentially expressed genes in papillary thyroid cancers. (19259350)
2009
34
Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study. (18073307)
2008
35
Normocalcemic, subclinical, asymptomatic primary hyperparathyroidism in patients with goiter or papillary thyroid cancer--preliminary report. Normocalcemic primary hyperparathyroidism and thyroid pathology. (17966885)
2007
36
Selective growth inhibition in BRAF mutant thyroid cancer by the mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244. (17878251)
2007
37
Thyrotoxicosis revealing metastases of unrecognized thyroid cancer: a report on two cases. (17905194)
2007
38
Prognostic significance of successful ablation with radioiodine of differentiated thyroid cancer patients. (15762184)
2005
39
Estimation of sodium/iodide symporter gene expression (NIS) in thyroid cancer by RT-PCR technique (preliminary study)]. (16335670)
2005
40
Preoperative determination of serum thyroglobulin to identify patients with differentiated thyroid cancer who may present recurrence without increased thyroglobulin. (16116831)
2005
41
Thymic hyperplasia in thyroid cancer patients. (15729115)
2005
42
Value of (124)I-PET/CT in staging of patients with differentiated thyroid cancer. (15232708)
2004
43
Differentiated thyroid carcinomas from children and adolescents express IGF-I and the IGF-I receptor (IGF-I-R). Cancers with the most intense IGF-I-R expression may be more aggressive. (14973173)
2004
44
Choroidal and skin metastases from papillary thyroid cancer: case and a review of the literature. (15531474)
2004
45
The role of apoptosis-inducing receptors of the tumor necrosis factor family in thyroid cancer. (12904168)
2003
46
Association of hyperfunctioning thyroid adenoma with thyroid cancer presenting as "trapping only" nodule at 99mTcO4- scintigraphy. (15008253)
2003
47
Susceptibility of thyroid cancer cells to 7-hydroxystaurosporine-induced apoptosis correlates with Bcl-2 protein level. (11525264)
2001
48
Expression of cholecystokinin-B/gastrin receptors in medullary thyroid cancer. (10452255)
1999
49
Fine-needle biopsy of cervical lymph nodes in patients with thyroid cancer: a prospective comparison of cytopathologic and tissue marker analysis. (8497644)
1993
50
Results of a screening program for C-cell disease (medullary thyroid cancer and C-cell hyperplasia). (2311068)
1990

Genetic Variations for Thyroid Cancer

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Expression for genes affiliated with Thyroid Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroid Cancer

Search GEO for disease gene expression data for Thyroid Cancer.

Pathways for genes affiliated with Thyroid Cancer

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Sources:
53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 49PharmGKB, 59Tocris Bioscience, 52R&D Systems
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Pathways related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.9NRAS, EGF, BRAF, PTEN, CALCA, PIK3CA
211.7CDKN1A, BRAF, PPARG, PIK3CA, EGF, NRAS
3
Hide members
11.5HRAS, NRAS, CDKN1A, EGF, PTEN, PIK3CA
411.3CDKN1A, NRAS, PIK3CA, HRAS, PTEN, RASSF1
5
Hide members
11.3PIK3CA, EGF, CDKN1A, PTEN, HRAS, NRAS
6
Hide members
11.3NRAS, PIK3CA, CDKN1A, EGF, HRAS, PTEN
711.3HRAS, PTEN, EGF, NRAS, PIK3CA, CDKN1A
811.3PTEN, HRAS, NRAS, PIK3CA, EGF, CDKN1A
9
Hide members
11.3PIK3CA, CDKN1A, HRAS, PTEN, EGF, NRAS
10
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11.3PIK3CA, EGF, PTEN, HRAS, NRAS, BRAF
11
Hide members
11.3PIK3CA, EGF, NRAS, HRAS, PTEN, BRAF
12
Translation Insulin regulation of translation
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11.3HRAS, NRAS, EGF, PTEN, PIK3CA, BRAF
13
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11.3BRAF, EGF, CDKN1A, HRAS, NRAS, PIK3CA
14
Hide members
11.3NRAS, BRAF, EGF, CDKN1A, HRAS, PIK3CA
1511.3EGF, BRAF, PIK3CA, NRAS, HRAS, CDKN1A
16
Hide members
11.3PTEN, HRAS, NRAS, EGF, PPARG, BRAF
1711.3HRAS, CDKN1A, EGF, BRAF, NRAS, PTEN
18
Hide members
11.3PIK3CA, BRAF, HRAS, EGF, NRAS, RET
1911.3RET, PAX8, BRAF, PPARG, NRAS, HRAS
20
Hide members
11.2NRAS, PIK3CA, CDKN1A, HRAS, PTEN
21
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11.2HRAS, BRAF, NRAS, EGF, PIK3CA
22
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11.2HRAS, BRAF, PIK3CA, NRAS, PTEN
23
Hide members
11.2BRAF, PTEN, HRAS, NRAS, EGF
24
Hide members
11.2HRAS, PIK3CA, NRAS, PPARG, BRAF
2511.2BRAF, NRAS, CDKN1A, HRAS, PIK3CA
26
Transcription Androgen Receptor nuclear signaling
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11.2EGF, PTEN, CDKN1A, PIK3CA, HRAS
27
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11.2PTEN, CDKN1A, PIK3CA, BRAF, HRAS
28
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11.2HRAS, RET, NRAS, PIK3CA, BRAF
2911.2PTTG1, PIK3CA, NRAS, CDKN1A, HRAS
3011.2CDKN1A, EGF, PIK3CA, PTEN, PTTG1
31
Hide members
11.0EGF, HRAS, PIK3CA, NRAS
32
Hide members
11.0EGF, HRAS, NRAS, PIK3CA
33
Hide members
11.0NRAS, EGF, HRAS, BRAF
34
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11.0BRAF, PTEN, HRAS, NRAS
35
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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11.0BRAF, PPARG, HRAS, NRAS
36
Development Ligand-independent activation of ESR1 and ESR2
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11.0PPARG, PIK3CA, EGF, HRAS
37
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11.0BRAF, CDKN1A, HRAS, NRAS
38
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11.0PIK3CA, HRAS, PTEN, CDKN1A
3911.0BRAF, EGF, RASSF1, PIK3CA
4011.0BRAF, CDKN1A, HRAS, PTEN
4111.0PIK3CA, BRAF, PAX8, HRAS
4210.9PIK3CA, NRAS, HRAS
43
Hide members
10.9HRAS, NRAS, PIK3CA
44
Hide members
10.9EGF, NRAS, HRAS
45
Hide members
10.9HRAS, NRAS, BRAF
46
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10.9BRAF, NRAS, HRAS
4710.9EGF, HRAS, PIK3CA
48
G-protein signaling Cross-talk between Ras-family GTPases
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10.9HRAS, PIK3CA, BRAF
4910.9RET, PIK3CA, HRAS
50
G-protein signaling H-RAS regulation pathway
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10.9HRAS, PIK3CA, RET

Compounds for genes affiliated with Thyroid Cancer

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1vegf4412.6EGF, PIK3CA, PPARG, CALCA, BRAF, CDKN1A
2retinoic acid44 2413.6BRAF, PPARG, PIK3CA, EGF, NKX2-1, CDKN1A
3tyrosine4412.6NRAS, NKX2-1, EGF, PIK3CA, BRAF, CDKN1A
4agar4412.5TG, BRAF, PIK3CA, EGF, NRAS, CDKN1A
5threonine4412.5BRAF, PIK3CA, EGF, NKX2-1, CDKN1A, RET
6oligonucleotide4412.3CDKN1A, NRAS, NKX2-1, BRAF, RET, HRAS
7ly2940024412.0BRAF, PPARG, PIK3CA, EGF, CDKN1A, RET
8calcium44 49 11 2415.0BRAF, CALCA, PIK3CA, EGF, RET, HRAS
9paraffin4412.0BRAF, NKX2-1, CDKN1A, RET, HRAS, PTEN
10genistein44 28 59 2 11 2417.0PPARG, PIK3CA, EGF, CDKN1A, RET, HRAS
11cisplatin44 49 59 1115.0BRAF, PIK3CA, EGF, CDKN1A, HRAS, RASSF1
12cyclic amp44 2413.0BRAF, CALCA, EGF, NKX2-1, RET, HRAS
13progesterone44 59 28 11 2416.0BRAF, PIK3CA, EGF, NKX2-1, CDKN1A, HRAS
14phosphatidylinositol4412.0BRAF, PIK3CA, EGF, RET, HRAS, PTEN
15alanine4411.9BRAF, PPARG, RET, KISS1R, RASSF1, PTEN
16serine4411.9PIK3CA, NKX2-1, RET, HRAS, RASSF1, PAX8
17rapamycin4411.9BRAF, PPARG, PIK3CA, EGF, CDKN1A, HRAS
18pd 98,0594411.9BRAF, PIK3CA, EGF, CDKN1A, RET, HRAS
19wortmannin4411.9BRAF, PIK3CA, EGF, CDKN1A, RET, HRAS
20thymidine44 2412.8PIK3CA, EGF, CDKN1A, HRAS, PTTG1, TSHR
21testosterone44 59 11 2414.8CALCA, PPARG, PIK3CA, EGF, RET, PTEN
22sodium iodide4411.8BRAF, NKX2-1, RET, PAX8, TSHR, TG
23arginine4411.7BRAF, PIK3CA, RET, HRAS, PTEN, TSHR
24ribonucleic acid4411.7NKX2-1, RET, PAX8, PTTG1, TSHR, TG
2512-o-tetradecanoylphorbol 13-acetate4411.7BRAF, EGF, CDKN1A, RET, HRAS, TSHR
26paclitaxel44 49 1113.7BRAF, PIK3CA, EGF, CDKN1A, HRAS, PTEN
27phosphoinositide4411.6BRAF, PIK3CA, EGF, HRAS, PTEN, TSHR
28forskolin44 49 1113.6BRAF, CALCA, EGF, NKX2-1, PAX8, TSHR
29iodide44 2412.6BRAF, PIK3CA, NKX2-1, PAX8, TG
30crcs4411.6BRAF, PIK3CA, HRAS, RASSF1, PTEN
31aspartate4411.6BRAF, RET, HRAS, PTEN, TSHR, TG
32rosiglitazone44 49 28 11 2415.5PPARG, PIK3CA, CDKN1A, PTEN, TSHR
33thyroxine44 2412.5CALCA, PPARG, PAX8, TSHR, TG
34imatinib44 49 1113.5BRAF, PIK3CA, CDKN1A, RET, PTEN
35calcitriol44 59 11 2414.5CALCA, EGF, CDKN1A, PTEN, TG
36phosphotyrosine4411.4PIK3CA, EGF, RET, HRAS, PTEN
37adenylate4411.4CALCA, PIK3CA, EGF, HRAS, TSHR, TG
38estrogen4411.3TG, TSHR, PTTG1
39h2o24411.3EGF, CDKN1A, HRAS, PTEN, TG, PIK3CA
40gefitinib44 49 1113.3PIK3CA, EGF, CDKN1A, PTEN
41panitumumab44 49 1113.3BRAF, EGF, PTEN
42gemcitabine44 49 1113.2PTEN, HRAS, CDKN1A, EGF
43phenylacetate4411.2HRAS, CDKN1A, PPARG
44pge24411.2PTEN, HRAS, CDKN1A
45lovastatin44 49 59 28 1115.1EGF, CDKN1A, HRAS, PTEN
46sodium44 2412.1TG, PAX8
47methionine4411.1RET, HRAS, RASSF1, PTEN, TSHR
48iodine44 2412.1BRAF, TSHR, TG
49manumycin4410.9HRAS, CDKN1A, EGF
50gf 109203x44 5911.7HRAS, CDKN1A, EGF, PPARG

GO Terms for genes affiliated with Thyroid Cancer

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Sources:
16Gene Ontology
See all sources

Biological processes related to Thyroid Cancer according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathwayGO:00854311.8PTEN, HRAS, CDKN1A, NRAS, EGF, PIK3CA
2neurotrophin TRK receptor signaling pathwayGO:04801111.8BRAF, PIK3CA, EGF, NRAS, CDKN1A, HRAS
3innate immune responseGO:04508711.7PPARG, PIK3CA, EGF, NRAS, CDKN1A, HRAS
4Fc-epsilon receptor signaling pathwayGO:03809511.6PIK3CA, EGF, NRAS, CDKN1A, HRAS, PTEN
5epidermal growth factor receptor signaling pathwayGO:00717311.6PIK3CA, EGF, NRAS, CDKN1A, HRAS, PTEN
6activation of MAPKK activityGO:00018611.5BRAF, EGF, NRAS, HRAS, KISS1R
7negative regulation of cell proliferationGO:00828511.4CDKN1A, RNF139, HRAS, KISS1R, PTEN
8Ras protein signal transductionGO:00726511.3NRAS, CDKN1A, HRAS, RASSF1
9positive regulation of cell proliferationGO:00828411.3EGF, NRAS, HRAS, PTEN, TSHR
10phosphatidylinositol-mediated signalingGO:04801511.2PIK3CA, EGF, CDKN1A, PTEN
11positive regulation of transcription, DNA-dependentGO:04589311.2PPARG, EGF, NKX2-1, RET, PAX8
12thyroid gland developmentGO:03087811.1TG, PAX8, NKX2-1
13endothelial cell migrationGO:04354211.1CALCA, PIK3CA, PTEN
14MAPK cascadeGO:00016511.0HRAS, RET, NRAS
15positive regulation of Rac protein signal transductionGO:03502210.9HRAS, NRAS
16positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.8PTEN, EGF
17regulation of synaptic transmission, GABAergicGO:03222810.7HRAS, NRAS
18striated muscle cell differentiationGO:05114610.5HRAS, NRAS

Molecular functions related to Thyroid Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.4BRAF, CALCA, PPARG, PIK3CA, EGF, NKX2-1
2thyroid-stimulating hormone receptor activityGO:00499610.8PAX8, TSHR

Products for genes affiliated with Thyroid Cancer

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Sources for Thyroid Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet