MCID: THY028
MIFTS: 73

Thyroid Cancer malady

Cancer diseases, Endocrine diseases categories
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Summaries for Thyroid Cancer

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it makes hormones that help the body work normally. there are several types of cancer of the thyroid gland. you are at greater risk if you are between ages 25 and 65 are a woman are asian have a family member who has had thyroid disease have had radiation treatments to your head or neck you should see a doctor if you have a lump or swelling in your neck. doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose thyroid cancer. treatment depends on the type of cancer you have and how far the cancer has spread. many patients receive a combination of treatments. they may include surgery, radioactive iodine, hormone treatment, radiation therapy, chemotherapy, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Thyroid Cancer, also known as thyroid carcinoma, is related to thyroiditis and goiter. An important gene associated with Thyroid Cancer is NKX2-1 (NK2 homeobox 1), and among its related pathways are EGFR Transactivation by Gastrin and SHC1 events in ERBB2 signaling. The drugs interferon alfa-2b and thyroglobulin and the compounds panitumumab and phenylacetate have been mentioned in the context of this disorder. Affiliated tissues include the thryoid gl, thyroid and testes, and related mouse phenotypes are muscle and adipose tissue.

Disease Ontology:8 An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.

Wikipedia:65 Thyroid cancer is a cancer originating from follicular or parafollicular thyroid cells. more...

Aliases & Classifications for Thyroid Cancer

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

thyroid cancer 8 10 45 34
thyroid carcinoma 8 45 62
thyroid neoplasm 8 62
malignant neoplasm of thyroid gland 8
malignant tumour of thyroid gland 8
head and neck cancer, thyroid 8
malignant neoplasm of thyroid 62
neoplasm of thyroid gland 8
thyroid gland neoplasm 8


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Disease Ontology8 DOID:1781, DOID:3963
NCIt40 C7510, C4815
ICD9CM27 193
MeSH35 D013964
ICD1025 C73

Related Diseases for Thyroid Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Thyroid Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 321)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis32.4TG, TSHR, CALCA
2goiter31.0TG, BRAF, PAX8, TSHR, RET, CALCA
3graves' disease30.8TG, PAX8, TSHR, NKX2-1
4multiple endocrine neoplasia30.7TG, RET, CALCA
5multinodular goiter30.7CALCA, TSHR, TG
6struma ovarii30.7TG, TSHR, NKX2-1
7thyroid carcinoma, follicular, somatic30.6PTEN, NRAS, HRAS
8nodular goiter30.5TG, BRAF, TSHR, RET, CALCA, HRAS
9endemic goiter30.5TG, TSHR
10hypothyroidism30.5NKX2-1, TSHR, TG
11papillary carcinoma30.5PAX8, TSHR, RET, CALCA, NKX2-1, HRAS
12familial adenomatous polyposis30.5PPARG, BRAF, NRAS, RASSF1
13papillary thyroid carcinoma30.5EGF, CDKN1A, KISS1R, NNMT, PPARG, PIK3CA
14thyrotoxicosis30.5TG, TSHR
15pituitary adenoma30.5RET, PTTG1, PPARG
16retinoblastoma30.4PPARG, PIK3CA, RASSF1, CDKN1A, EGF, HRAS
17autoimmune thyroiditis30.4TG, CALCA
18thyroid medullary carcinoma30.4NKX2-1, CALCA, RET, BRAF, TG
19paraganglioma30.4TG, RET, CALCA
20adenocarcinoma30.4PIK3CA, PTTG1, PTEN, BRAF, NKX2-1, RASSF1
21follicular thyroid carcinoma30.4PPARG, PTEN, TG, BRAF, PAX8, TSHR
22melanoma30.3PIK3CA, PTEN, BRAF, TSHR, NKX2-1, NRAS
23leukemia30.3PIK3CA, PTTG1, TSHR, NRAS, CDKN1A, EGF
24lung adenocarcinoma30.2PIK3CA, BRAF, NKX2-1, RASSF1, CDKN1A, EGF
25neuroma30.2RET, CALCA
26neuroendocrine tumor30.2PAX8, RET, CALCA, NKX2-1, RASSF1
27adenoma30.2PPARG, PTTG1, TG, BRAF, PAX8, TSHR
28familial medullary thyroid carcinoma30.2RET, CALCA
29breast cancer30.2PIK3CA, PTTG1, PTEN, NKX2-1, RASSF1, CDKN1A
30thyroid cancer, anaplastic30.2PAX8, TSHR, RET, CALCA, NKX2-1, CDKN1A
31cowden syndrome 130.1PTEN
32myxedema30.1TSHR, TG
33thyroid adenoma30.0PPARG, PIK3CA, PTEN, TG, BRAF, TSHR
34subacute thyroiditis30.0TG, TSHR
35nontoxic goiter30.0TG, TSHR
36squamous cell carcinoma of the head and neck30.0EGF, CDKN1A, RASSF1, PIK3CA
37cowden disease30.0RET, PTEN, PIK3CA
38glioblastoma multiforme29.9PIK3CA, PTEN, CDKN1A, EGF
39brain cancer29.9PIK3CA, PTEN, CDKN1A, EGF
40colon cancer29.9PIK3CA, PTTG1, BRAF, CDKN1A, EGF, HRAS
41astrocytoma29.9PIK3CA, PTTG1, PTEN, RASSF1, CDKN1A, EGF
42hepatocellular carcinoma29.8PIK3CA, PTTG1, PTEN, NKX2-1, RASSF1, KISS1R
43follicular adenoma29.7PPARG, PTEN, TG, BRAF, PAX8, TSHR
44cervicitis10.6
45endotheliitis10.5
46familial papillary thyroid carcinoma10.4
47thyroid hurthle cell carcinoma10.4
48hyperthyroidism10.4
49mediastinitis10.3
50nonmedullary thyroid carcinoma, with or without cell oxyphilia10.3

Graphical network of the top 20 diseases related to Thyroid Cancer:



Diseases related to thyroid cancer

Symptoms for Thyroid Cancer

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Drugs & Therapeutics for Thyroid Cancer

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Thyroid Cancer

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Anatomical Context for Thyroid Cancer

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Thyroid Cancer:

33
Thyroid, Testes, Lymph node, Endothelial, Bone, Lung, Breast, Pituitary, T cells, Salivary gland, Liver, Skin, Myeloid, Ovary, Brain, Nk cells, Colon, Thymus, Prostate, Testis, Cervix

FMA organs/tissues related to Thyroid Cancer:

14
The thryoid gl

Animal Models for Thyroid Cancer or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Thyroid Cancer:

37 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1CDKN1A, RET, BRAF, PTEN, PIK3CA, PPARG
2MP:00053759.1PPARG, PIK3CA, PTTG1, PTEN, BRAF, CDKN1A
3MP:00053889.0PTEN, BRAF, RET, CALCA, NKX2-1, CDKN1A
4MP:00053708.9PPARG, PTEN, BRAF, NRAS, KISS1R, CDKN1A
5MP:00053918.9PPARG, PIK3CA, PTEN, BRAF, NRAS, CDKN1A
6MP:00053818.9PTEN, BRAF, RET, NKX2-1, NRAS, KISS1R
7MP:00053778.9PPARG, PAX8, TSHR, CALCA, CDKN1A
8MP:00053908.7PPARG, PTEN, BRAF, PAX8, CALCA, NKX2-1
9MP:00030128.7PPARG, PIK3CA, PTTG1, PAX8, RET, NKX2-1
10MP:00107718.5PPARG, PIK3CA, PTEN, BRAF, CALCA, NRAS
11MP:00020068.4PPARG, PIK3CA, PTEN, BRAF, RET, CALCA
12MP:00028738.4PPARG, PTEN, BRAF, RET, CALCA, NRAS
13MP:00053978.3PPARG, PTTG1, PTEN, TG, BRAF, TSHR
14MP:00053808.2PTEN, PTTG1, PIK3CA, PPARG, BRAF, PAX8
15MP:00053678.2PPARG, PTTG1, PTEN, BRAF, PAX8, RET
16MP:00053858.1PAX8, BRAF, PTEN, PIK3CA, PPARG, RET
17MP:00053848.1PTEN, PTTG1, PIK3CA, PPARG, BRAF, PAX8
18MP:00053868.0BRAF, PTEN, PTTG1, PIK3CA, PPARG, TSHR
19MP:00053877.9BRAF, PTEN, PTTG1, PIK3CA, PPARG, TSHR
20MP:00053897.9PPARG, PIK3CA, PTTG1, PTEN, BRAF, PAX8
21MP:00053797.6HRAS, PPARG, PIK3CA, PTTG1, PTEN, TG
22MP:00036317.5BRAF, TG, PTEN, PTTG1, PIK3CA, PPARG
23MP:00053787.4BRAF, TG, PTEN, PTTG1, PIK3CA, PPARG
24MP:00107687.2PAX8, BRAF, PTEN, PTTG1, PIK3CA, PPARG
25MP:00053767.1PAX8, BRAF, TG, PTEN, PTTG1, PIK3CA

Publications for Thyroid Cancer

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52PubMed
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Articles related to Thyroid Cancer:

(show top 50)    (show all 1597)
idTitleAuthorsYear
1
Commentary on: Implications of thyroglobulin antibody positivity in patients with differentiated thyroid cancer: a clinical position statement. (23987661)
2013
2
Evolving approaches to patients with advanced differentiated thyroid cancer. (23575762)
2013
3
Synoptic pathology reporting for thyroid cancer: a review and institutional experience. (24053206)
2013
4
Vandetanib: a novel targeted therapy for the treatment of metastatic or locally advanced medullary thyroid cancer. (23640345)
2013
5
High-Risk Patients with Differentiated Thyroid Cancer T4 Primary Tumors Achieve Remnant Ablation Equally Well Using rhTSH or Thyroid Hormone Withdrawal. (24040896)
2013
6
Differentiated thyroid cancer: indications and extent of central neck dissection--our experience. (24282633)
2013
7
Severe Hyponatremia Following Radioactive Iodine Therapy in Patients with Differentiated Thyroid Cancer. (24093878)
2013
8
MK-2206 causes growth suppression and reduces neuroendocrine tumor marker production in medullary thyroid cancer through Akt inhibition. (23900743)
2013
9
Clinical behavior and genetics of nonsyndromic, familial nonmedullary thyroid cancer. (23652675)
2013
10
Marginal treatment benefit in anaplastic thyroid cancer. (23839797)
2013
11
Notch pathway is activated by MAPK signaling and influences papillary thyroid cancer proliferation. (23544172)
2013
12
Accidental discovery of lung metastases from differentiated thyroid cancer by 99mTc sodium pertechnetate scan in a patient with secondary hyperparathyroidism. (22889782)
2012
13
Incidental detection of hyperfunctioning thyroid cancer metastases in patients presenting with thyrotoxicosis. (22837931)
2012
14
BRAF(V600E) mutation in Turkish patients with papillary thyroid cancer: strong correlation with indicators of tumor aggressiveness. (22426956)
2012
15
Extended RET gene analysis in patients with apparently sporadic medullary thyroid cancer: clinical benefits and cost. (22648435)
2012
16
Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer. (21826673)
2012
17
Rearranged anaplastic lymphoma kinase (ALK) gene in adult-onset papillary thyroid cancer amongst atomic bomb survivors. (23050789)
2012
18
Expression of estrogen and androgen receptors in differentiated thyroid cancer: an additional criterion to assess the patient's risk. (22531679)
2012
19
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. (21606412)
2011
20
Current role of metaiodobenzylguanidine in the diagnosis of pheochromocytoma and medullary thyroid cancer. (21803186)
2011
21
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. (22105174)
2011
22
Germline RET sequence variation I852M and occult medullary thyroid cancer: harmless polymorphism or causative mutation? (21711375)
2011
23
Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. (20371662)
2010
24
Thyroid cancers amongst goiter population in a Nigerian tertiary hospital: surgical and radiographic perspective. (21526634)
2010
25
The mitogen-activated protein kinase (MAPK) signaling pathway in papillary thyroid cancer. From the molecular bases to clinical practice]. (19627734)
2009
26
Follicular thyroid cancer cell growth inhibition by proteosome inhibitor MG132. (19552924)
2009
27
Medullary thyroid cancer: molecular biology and novel molecular therapies. (19468197)
2009
28
Ablative free thyroxine to thyroglobulin ratio as a predictor of differentiated thyroid cancer recurrence. (19769825)
2009
29
Genetic aspects of familial thyroid cancer. (19465682)
2009
30
The follow-up of patients with differentiated thyroid cancer and undetectable thyroglobulin (Tg) and Tg antibodies during ablation. (18166820)
2008
31
Fluorodeoxyglucose PET/CT in patients with differentiated thyroid cancer and elevated thyroglobulin after total thyroidectomy and (131)I ablation. (17538522)
2008
32
Dysregulated RET signaling in thyroid cancer. (18502331)
2008
33
Predicting the development of Cushing's syndrome in medullary thyroid cancer: utility of proopiomelanocortin messenger ribonucleic acid in situ hybridization. (17696832)
2007
34
Normocalcemic, subclinical, asymptomatic primary hyperparathyroidism in patients with goiter or papillary thyroid cancer--preliminary report. Normocalcemic primary hyperparathyroidism and thyroid pathology. (17966885)
2007
35
Differential effects of cetuximab and AEE 788 on epidermal growth factor receptor (EGF-R) and vascular endothelial growth factor receptor (VEGF-R) in thyroid cancer cell lines. (17873319)
2007
36
Positive predictive value of detectable stimulated tg during the first year after therapy of thyroid cancer and the value of comparison with Tg-ablation and Tg measured after 24 months. (17123341)
2006
37
Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer. (16263812)
2006
38
Risk of thyroid cancer after childhood exposure to ionizing radiation for tinea capitis. (17018661)
2006
39
Additive antitumor effects of gefitinib and imatinib on anaplastic thyroid cancer cells. (16435154)
2006
40
Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. (15767343)
2005
41
Increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer. (16189643)
2005
42
Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. (15743786)
2005
43
Papillary thyroid cancer with chest metastases only detected using radioactive iodine. (15605906)
2004
44
Treatment of iodine-negative thyroglobulin-positive thyroid cancer: differences in outcome in patients with macrometastases and patients with micrometastases. (15232654)
2004
45
Procedure guidelines for radioiodine therapy of differentiated thyroid cancer (version 2)]. (15316577)
2004
46
Pulmonary epithelioid hemangioendothelioma coexistent with pulmonary metastasis of thyroid cancer. (11518122)
2001
47
Treating the patient with differentiated thyroid cancer with thyroglobulin-positive iodine-131 diagnostic scan-negative metastases: including comments on the role of serum thyroglobulin monitoring in tumor surveillance. (10787191)
2000
48
18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography localizes residual thyroid cancer in patients with negative diagnostic (131)I whole body scans and elevated serum thyroglobulin levels. (10404792)
1999
49
A case of follicular thyroid cancer with tracheal stenosis responded to external radiation therapy. (10378657)
1999
50
Infrequent CDKN2 mutation in human differentiated thyroid cancers. (8561866)
1996

Variations for Thyroid Cancer

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Expression for genes affiliated with Thyroid Cancer

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroid Cancer

Search GEO for disease gene expression data for Thyroid Cancer.

Pathways for genes affiliated with Thyroid Cancer

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 60Thomson Reuters, 61Tocris Bioscience, 53QIAGEN, 30KEGG, 12EMD Millipore, 51PharmGKB, 54R&D Systems
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Pathways related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
EGFR-dependent Endothelin signaling events38
9.9HRAS, EGF, NRAS
2
Show member pathways
9.9NRAS, EGF, HRAS
39.9RET, HRAS, PIK3CA
49.9HRAS, EGF, PIK3CA
5
Show member pathways
9.9BRAF, NRAS, HRAS
69.8PIK3CA, BRAF, HRAS
7
Show member pathways
9.7HRAS, EGF, NRAS, PIK3CA
8
Show member pathways
9.7PIK3CA, BRAF, NRAS, HRAS
99.7PIK3CA, BRAF, NRAS, HRAS
10
Show member pathways
9.7BRAF, NRAS, EGF, HRAS
11
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.7HRAS, CDKN1A, PTEN, PIK3CA
12
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
9.6PPARG, BRAF, NRAS, HRAS
139.6PTEN, BRAF, CDKN1A, HRAS
149.5PIK3CA, BRAF, RASSF1, EGF
159.5PIK3CA, BRAF, PAX8, HRAS
16
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.5PIK3CA, PTEN, NRAS, CDKN1A, HRAS
17
Show member pathways
9.5PIK3CA, BRAF, RET, NRAS, HRAS
18
Show member pathways
9.5HRAS, EGF, NRAS, BRAF, PIK3CA
19
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.5PIK3CA, PTEN, BRAF, NRAS, HRAS
20
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.5HRAS, EGF, CDKN1A, PTEN, PIK3CA
21
Show member pathways
9.4PTEN, BRAF, NRAS, EGF, HRAS
229.4PIK3CA, BRAF, NRAS, CDKN1A, HRAS
23
Show member pathways
9.4HRAS, CDKN1A, NRAS, BRAF, PIK3CA
24
Show member pathways
9.4PPARG, PIK3CA, BRAF, NRAS, HRAS
25
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.4PIK3CA, PTEN, BRAF, CDKN1A, HRAS
269.3HRAS, CDKN1A, NRAS, PTTG1, PIK3CA
27
Show member pathways
9.3PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
28
Show member pathways
9.3PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
29
Show member pathways
9.3PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
309.3PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
31
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.3PIK3CA, BRAF, RET, NRAS, EGF, HRAS
32
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
9.2PIK3CA, PTEN, BRAF, NRAS, EGF, HRAS
33
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.2PIK3CA, PTEN, BRAF, NRAS, EGF, HRAS
349.2PIK3CA, PTTG1, PTEN, CDKN1A, EGF
359.2PIK3CA, PTEN, NRAS, RASSF1, CDKN1A, HRAS
36
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.2PIK3CA, BRAF, NRAS, CDKN1A, EGF, HRAS
379.2PIK3CA, BRAF, NRAS, CDKN1A, EGF, HRAS
38
Show member pathways
9.2PIK3CA, BRAF, NRAS, CDKN1A, EGF, HRAS
399.2PTEN, BRAF, NRAS, CDKN1A, EGF, HRAS
40
Show member pathways
9.2PIK3CA, BRAF, NRAS, RASSF1, EGF, HRAS
41
Show member pathways
9.2HRAS, EGF, NRAS, BRAF, PTEN, PPARG
429.1PPARG, BRAF, PAX8, RET, NRAS, HRAS
43
Show member pathways
Signal transduction PTEN pathway60
9.0PIK3CA, PTEN, BRAF, NRAS, CDKN1A, EGF
44
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.0PIK3CA, PTEN, BRAF, NRAS, CDKN1A, EGF
45
Show member pathways
9.0PIK3CA, PTEN, BRAF, NRAS, CDKN1A, EGF
46
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.0PPARG, PIK3CA, PTEN, BRAF, NRAS, EGF
47
Show member pathways
Signaling Pathways in Glioblastoma38
8.8PIK3CA, PTEN, BRAF, NRAS, RASSF1, CDKN1A
488.7PIK3CA, PTEN, BRAF, CALCA, NRAS, CDKN1A
49
Show member pathways
8.2PIK3CA, PTEN, BRAF, TSHR, CALCA, NRAS
508.0HRAS, PPARG, PIK3CA, PTEN, BRAF, PAX8

Compounds for genes affiliated with Thyroid Cancer

About this section
Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1panitumumab45 51 1112.1EGF, BRAF, PTEN
2phenylacetate4510.1PPARG, CDKN1A, HRAS
3mithramycin459.9CDKN1A, CALCA, PPARG
4iodine45 2410.8TSHR, BRAF, TG
5gefitinib45 51 1111.8PIK3CA, PTEN, CDKN1A, EGF
6crcs459.8PIK3CA, PTEN, BRAF, RASSF1, HRAS
7gemcitabine45 51 1111.8HRAS, EGF, CDKN1A, PTEN
8rosiglitazone29 45 51 24 1113.8PPARG, PIK3CA, PTEN, TSHR, CDKN1A
9imatinib45 51 1111.7PIK3CA, PTEN, BRAF, RET, CDKN1A
10phosphotyrosine459.7PIK3CA, PTEN, RET, EGF, HRAS
11lovastatin45 51 61 29 1113.7HRAS, EGF, CDKN1A, PTEN
12calcitriol45 61 24 1112.6PTEN, TG, CALCA, CDKN1A, EGF
13sodium iodide459.6TG, NKX2-1, RET, TSHR, PAX8, BRAF
14thyroxine45 2410.6PPARG, TG, PAX8, TSHR, CALCA
15iodide45 2410.6PIK3CA, TG, BRAF, PAX8, TSHR, NKX2-1
1612-o-tetradecanoylphorbol 13-acetate459.6BRAF, TSHR, RET, CDKN1A, EGF, HRAS
17phosphoinositide459.5PIK3CA, PTEN, BRAF, TSHR, EGF, HRAS
18paclitaxel45 51 1111.5PIK3CA, PTEN, BRAF, CDKN1A, EGF, HRAS
19methionine459.5PTEN, TSHR, RET, RASSF1, HRAS
20aspartate459.5HRAS, RET, TSHR, BRAF, TG, PTEN
21ribonucleic acid459.4PTTG1, TG, PAX8, TSHR, RET, NKX2-1
22pge2459.4PPARG, PTEN, CALCA, CDKN1A, EGF, HRAS
23adenylate459.4PIK3CA, TG, TSHR, CALCA, EGF, HRAS
24pd 98,059459.4PIK3CA, PTEN, BRAF, RET, CDKN1A, EGF
25wortmannin459.4PIK3CA, PTEN, BRAF, RET, CDKN1A, EGF
26sodium45 2410.4PIK3CA, TG, BRAF, PAX8, TSHR, NKX2-1
27forskolin45 51 1111.4BRAF, PAX8, TSHR, CALCA, NKX2-1, EGF
28rapamycin459.3PPARG, PIK3CA, PTEN, BRAF, CDKN1A, EGF
29arginine459.3PIK3CA, PTEN, TG, BRAF, TSHR, RET
30thymidine45 2410.3PIK3CA, PTTG1, TG, TSHR, CDKN1A, EGF
31paraffin459.3PTEN, TG, BRAF, TSHR, RET, NKX2-1
32testosterone45 61 24 1112.3PPARG, PIK3CA, PTEN, TG, RET, CALCA
33genistein45 29 61 3 24 1114.3PPARG, PIK3CA, PTEN, TG, RET, CDKN1A
34progesterone45 29 61 24 1113.2PIK3CA, PTEN, BRAF, TSHR, NKX2-1, CDKN1A
35cyclic amp45 2410.2PTEN, BRAF, TSHR, RET, CALCA, NKX2-1
36ly294002459.2PPARG, PIK3CA, PTEN, BRAF, RET, CDKN1A
37cisplatin45 51 61 1112.2PIK3CA, PTEN, TG, BRAF, RASSF1, CDKN1A
38phosphatidylinositol459.1PIK3CA, PTTG1, PTEN, BRAF, TSHR, RET
39alanine459.0PPARG, PTEN, TG, BRAF, TSHR, RET
40h2o2459.0PIK3CA, PTEN, TG, CDKN1A, EGF, HRAS
41cysteine458.9PTTG1, PTEN, TG, TSHR, RET, EGF
42oligonucleotide458.7TSHR, PAX8, BRAF, PTEN, RET, NKX2-1
43threonine458.5PIK3CA, PTEN, BRAF, PAX8, TSHR, RET
44agar458.5RASSF1, NRAS, RET, BRAF, TG, PTEN
45tyrosine458.4TSHR, BRAF, TG, PTEN, PIK3CA, RET
46retinoic acid45 249.4BRAF, TG, PTEN, PIK3CA, PPARG, TSHR
47calcium45 51 24 1111.4PIK3CA, PTTG1, PTEN, BRAF, TSHR, RET
48serine458.3PAX8, BRAF, TG, PTEN, PIK3CA, TSHR
49vegf458.2PPARG, PIK3CA, PTTG1, PTEN, TG, BRAF
50estrogen458.0HRAS, EGF, CDKN1A, RASSF1, NKX2-1, CALCA

GO Terms for genes affiliated with Thyroid Cancer

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16Gene Ontology
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Cellular components related to Thyroid Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.5PTEN, BRAF, TSHR, NRAS, RASSF1, KISS1R
2cytosolGO:0058298.1HRAS, NNMT, PPARG, PIK3CA, PTTG1, PTEN

Biological processes related to Thyroid Cancer according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Rac protein signal transductionGO:03502210.3NRAS, HRAS
2regulation of synaptic transmission, GABAergicGO:03222810.3HRAS, NRAS
3thyroid-stimulating hormone signaling pathwayGO:03819410.3PAX8, TSHR
4thyroid gland developmentGO:03087810.1NKX2-1, PAX8, TG
5positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.1PTEN, EGF
6MAPK cascadeGO:00016510.1RET, NRAS, HRAS
7endothelial cell migrationGO:04354210.1PIK3CA, PTEN, CALCA
8striated muscle cell differentiationGO:05114610.0HRAS, NRAS
9response to arsenic-containing substanceGO:04668510.0PTEN, CDKN1A
10Ras protein signal transductionGO:00726510.0NRAS, RASSF1, CDKN1A, HRAS
11negative regulation of neuron apoptotic processGO:04352410.0HRAS, NRAS, BRAF, PIK3CA
12leukocyte migrationGO:0509009.9HRAS, NRAS, PIK3CA
13phosphatidylinositol-mediated signalingGO:0480159.9EGF, CDKN1A, PTEN, PIK3CA
14organ regenerationGO:0311009.8NNMT, PPARG, CDKN1A
15positive regulation of cell proliferationGO:0082849.8HRAS, EGF, NRAS, TSHR, PTEN
16activation of MAPKK activityGO:0001869.7BRAF, NRAS, KISS1R, EGF, HRAS
17negative regulation of cell proliferationGO:0082859.7PTEN, RNF139, KISS1R, CDKN1A, HRAS
18Fc-epsilon receptor signaling pathwayGO:0380959.6PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
19epidermal growth factor receptor signaling pathwayGO:0071739.6PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
20positive regulation of transcription, DNA-templatedGO:0458939.5EGF, NKX2-1, RET, PAX8, PPARG
21response to drugGO:0424939.5NNMT, PPARG, PTEN, RET, CDKN1A
22fibroblast growth factor receptor signaling pathwayGO:0085439.4HRAS, PIK3CA, PTEN, BRAF, NRAS, CDKN1A
23innate immune responseGO:0450879.4PPARG, PIK3CA, PTEN, NRAS, CDKN1A, EGF
24neurotrophin TRK receptor signaling pathwayGO:0480119.4PIK3CA, PTEN, BRAF, NRAS, CDKN1A, EGF
25protein phosphorylationGO:0064689.2BRAF, RET, CALCA, CDKN1A

Molecular functions related to Thyroid Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid-stimulating hormone receptor activityGO:00499610.0TSHR, PAX8
2protein bindingGO:0055156.4HRAS, PPARG, PIK3CA, PTTG1, PTEN, BRAF

Products for genes affiliated with Thyroid Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thyroid Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet