MCID: THY028
MIFTS: 74

Thyroid Cancer malady

Cancer diseases, Endocrine diseases categories

Summaries for Thyroid Cancer

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MedlinePlus:33 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it makes hormones that help the body work normally. there are several types of cancer of the thyroid gland. you are at greater risk if you are between ages 25 and 65 are a woman are asian have a family member who has had thyroid disease have had radiation treatments to your head or neck you should see a doctor if you have a lump or swelling in your neck. doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose thyroid cancer. treatment depends on the type of cancer you have and how far the cancer has spread. many patients receive a combination of treatments. they may include surgery, radioactive iodine, hormone treatment, radiation therapy, chemotherapy, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards based summary: Thyroid Cancer, also known as thyroid carcinoma, is related to thyroiditis and struma ovarii. An important gene associated with Thyroid Cancer is NKX2-1 (NK2 homeobox 1), and among its related pathways are EGFR Transactivation by Gastrin and SHC1 events in ERBB2 signaling. The drugs interferon alfa-2b and thyroglobulin and the compounds panitumumab and phenylacetate have been mentioned in the context of this disorder. Affiliated tissues include the thryoid gl, thyroid and testes, and related mouse phenotypes are muscle and adipose tissue.

Disease Ontology:9 An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.

Wikipedia:64 Thyroid cancer is a cancer originating from follicular or parafollicular thyroid cells. more...

Aliases & Classifications for Thyroid Cancer

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Thyroid Cancer, Aliases & Descriptions:

Name: Thyroid Cancer 9 11 44 33
Thyroid Carcinoma 9 44 61
Malignant Neoplasm of Thyroid Gland 9 61
Neoplasm of Thyroid Gland 9 61
Thyroid Gland Neoplasm 9 61
 
Thyroid Neoplasm 9 61
Malignant Tumour of Thyroid Gland 9
Head and Neck Cancer, Thyroid 9
Malignant Neoplasm of Thyroid 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:1781, DOID:3963
NCIt39 C7510, C4815
ICD9CM28 193
MeSH34 D013964

Related Diseases for Thyroid Cancer

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Diseases related to Thyroid Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 334)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis32.8TG, TSHR, CALCA
2struma ovarii31.2TG, TSHR, NKX2-1
3multiple endocrine neoplasia31.2TG, RET, CALCA
4multinodular goiter31.1CALCA, TSHR, TG
5endemic goiter31.1TG, TSHR
6graves' disease31.1TG, PAX8, TSHR, NKX2-1
7thyroid carcinoma, follicular, somatic31.1PTEN, NRAS, HRAS
8hypothyroidism31.0NKX2-1, TSHR, TG
9thyrotoxicosis31.0TG, TSHR
10goiter31.0TG, BRAF, PAX8, TSHR, RET, CALCA
11autoimmune thyroiditis30.9TG, CALCA
12paraganglioma30.8TG, RET, CALCA
13familial adenomatous polyposis30.8PPARG, BRAF, NRAS, RASSF1
14nodular goiter30.7TG, BRAF, TSHR, RET, CALCA, HRAS
15familial medullary thyroid carcinoma30.7RET, CALCA
16cowden syndrome 130.7PTEN
17thyroid medullary carcinoma30.7NKX2-1, CALCA, RET, BRAF, TG
18neuroma30.6RET, CALCA
19pituitary adenoma30.6RET, PTTG1, PPARG
20subacute thyroiditis30.6TG, TSHR
21myxedema30.6TSHR, TG
22retinoblastoma30.5PPARG, PIK3CA, RASSF1, CDKN1A, EGF, HRAS
23nontoxic goiter30.5TG, TSHR
24cowden disease30.4RET, PTEN, PIK3CA
25neuroendocrine tumor30.4PAX8, RET, CALCA, NKX2-1, RASSF1
26lung adenocarcinoma30.3PIK3CA, BRAF, NKX2-1, RASSF1, CDKN1A, EGF
27papillary carcinoma30.2PAX8, TSHR, RET, CALCA, NKX2-1, HRAS
28squamous cell carcinoma of the head and neck30.2EGF, CDKN1A, RASSF1, PIK3CA
29leukemia30.2PIK3CA, PTTG1, TSHR, NRAS, CDKN1A, EGF
30glioblastoma multiforme30.2PIK3CA, PTEN, CDKN1A, EGF
31brain cancer30.2PIK3CA, PTEN, CDKN1A, EGF
32melanoma30.1PIK3CA, PTEN, BRAF, TSHR, NKX2-1, NRAS
33adenocarcinoma30.1PIK3CA, PTTG1, PTEN, BRAF, NKX2-1, RASSF1
34breast cancer30.1PIK3CA, PTTG1, PTEN, NKX2-1, RASSF1, CDKN1A
35follicular thyroid carcinoma30.1PPARG, PTEN, TG, BRAF, PAX8, TSHR
36thyroid adenoma29.9PPARG, PIK3CA, PTEN, TG, BRAF, TSHR
37glioblastoma29.8PPARG, PIK3CA, PTEN, RASSF1, CDKN1A, EGF
38papillary thyroid carcinoma29.6EGF, CDKN1A, KISS1R, NNMT, PPARG, PIK3CA
39thyroid cancer, anaplastic29.5PAX8, TSHR, RET, CALCA, NKX2-1, CDKN1A
40thyroid hurthle cell carcinoma29.5PPARG, PIK3CA, PTTG1, PTEN, TG, BRAF
41adenoma29.5PPARG, PTTG1, TG, BRAF, PAX8, TSHR
42follicular adenoma29.4PPARG, PTEN, TG, BRAF, PAX8, TSHR
43leopard syndrome10.6HRAS
44cervicitis10.5
45endotheliitis10.5
46toxic diffuse goiter10.5TSHR, TG
47cardiofaciocutaneous syndrome10.5BRAF
48familial papillary thyroid carcinoma10.4
49spitz nevus10.4BRAF, HRAS
50hyperthyroidism10.4

Graphical network of the top 20 diseases related to Thyroid Cancer:



Diseases related to thyroid cancer

Symptoms for Thyroid Cancer

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Drugs & Therapeutics for Thyroid Cancer

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Genetic Tests for Thyroid Cancer

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Anatomical Context for Thyroid Cancer

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MalaCards organs/tissues related to Thyroid Cancer:

32
Thyroid, Testes, Lymph node, Endothelial, Bone, Lung, Breast, Pituitary, T cells, Liver, Salivary gland, Skin, Ovary, Myeloid, Thymus, Brain, Colon, Prostate, Testis, Cervix, Nk cells

FMA organs/tissues related to Thyroid Cancer:

15
The thryoid gl

Animal Models for Thyroid Cancer or affiliated genes

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MGI Mouse Phenotypes related to Thyroid Cancer:

36 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1CDKN1A, RET, BRAF, PTEN, PIK3CA, PPARG
2MP:00053759.1PPARG, PIK3CA, PTTG1, PTEN, BRAF, CDKN1A
3MP:00053889.0PTEN, BRAF, RET, CALCA, NKX2-1, CDKN1A
4MP:00053708.9PPARG, PTEN, BRAF, NRAS, KISS1R, CDKN1A
5MP:00053918.9PPARG, PIK3CA, PTEN, BRAF, NRAS, CDKN1A
6MP:00053818.9PTEN, BRAF, RET, NKX2-1, NRAS, KISS1R
7MP:00053778.9PPARG, PAX8, TSHR, CALCA, CDKN1A
8MP:00053908.7PPARG, PTEN, BRAF, PAX8, CALCA, NKX2-1
9MP:00030128.7PPARG, PIK3CA, PTTG1, PAX8, RET, NKX2-1
10MP:00107718.5PPARG, PIK3CA, PTEN, BRAF, CALCA, NRAS
11MP:00020068.4PPARG, PIK3CA, PTEN, BRAF, RET, CALCA
12MP:00028738.4PPARG, PTEN, BRAF, RET, CALCA, NRAS
13MP:00053978.3PPARG, PTTG1, PTEN, TG, BRAF, TSHR
14MP:00053808.2PTEN, PTTG1, PIK3CA, PPARG, BRAF, PAX8
15MP:00053678.2PPARG, PTTG1, PTEN, BRAF, PAX8, RET
16MP:00053858.1PAX8, BRAF, PTEN, PIK3CA, PPARG, RET
17MP:00053848.1PTEN, PTTG1, PIK3CA, PPARG, BRAF, PAX8
18MP:00053868.0BRAF, PTEN, PTTG1, PIK3CA, PPARG, TSHR
19MP:00053877.9BRAF, PTEN, PTTG1, PIK3CA, PPARG, TSHR
20MP:00053897.9PPARG, PIK3CA, PTTG1, PTEN, BRAF, PAX8
21MP:00053797.6HRAS, PPARG, PIK3CA, PTTG1, PTEN, TG
22MP:00036317.5BRAF, TG, PTEN, PTTG1, PIK3CA, PPARG
23MP:00053787.4BRAF, TG, PTEN, PTTG1, PIK3CA, PPARG
24MP:00107687.2PAX8, BRAF, PTEN, PTTG1, PIK3CA, PPARG
25MP:00053767.1PAX8, BRAF, TG, PTEN, PTTG1, PIK3CA

Publications for Thyroid Cancer

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Articles related to Thyroid Cancer:

(show top 50)    (show all 1636)
idTitleAuthorsYear
1
Association of the miR-149 Rs2292832 Polymorphism with Papillary Thyroid Cancer Risk and Clinicopathologic Characteristics in a Chinese Population. (25405731)
2014
2
Commentary on: Implications of thyroglobulin antibody positivity in patients with differentiated thyroid cancer: a clinical position statement. (23987661)
2013
3
Evolving approaches to patients with advanced differentiated thyroid cancer. (23575762)
2013
4
Vandetanib: a novel targeted therapy for the treatment of metastatic or locally advanced medullary thyroid cancer. (23640345)
2013
5
High-Risk Patients with Differentiated Thyroid Cancer T4 Primary Tumors Achieve Remnant Ablation Equally Well Using rhTSH or Thyroid Hormone Withdrawal. (24040896)
2013
6
Differentiated thyroid cancer: indications and extent of central neck dissection--our experience. (24282633)
2013
7
Severe Hyponatremia Following Radioactive Iodine Therapy in Patients with Differentiated Thyroid Cancer. (24093878)
2013
8
Immunohistochemical detection of mutated BRAF V600E supports the clonal origin of BRAF-induced thyroid cancers along the spectrum of disease progression. (23775351)
2013
9
The current status of lymph node dissection in the treatment of papillary thyroid cancer. A literature review. (24045534)
2013
10
MK-2206 causes growth suppression and reduces neuroendocrine tumor marker production in medullary thyroid cancer through Akt inhibition. (23900743)
2013
11
Clinical behavior and genetics of nonsyndromic, familial nonmedullary thyroid cancer. (23652675)
2013
12
Marginal treatment benefit in anaplastic thyroid cancer. (23839797)
2013
13
Accidental discovery of lung metastases from differentiated thyroid cancer by 99mTc sodium pertechnetate scan in a patient with secondary hyperparathyroidism. (22889782)
2012
14
Incidental detection of hyperfunctioning thyroid cancer metastases in patients presenting with thyrotoxicosis. (22837931)
2012
15
BRAF(V600E) mutation in Turkish patients with papillary thyroid cancer: strong correlation with indicators of tumor aggressiveness. (22426956)
2012
16
Extended RET gene analysis in patients with apparently sporadic medullary thyroid cancer: clinical benefits and cost. (22648435)
2012
17
Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer. (21826673)
2012
18
Rearranged anaplastic lymphoma kinase (ALK) gene in adult-onset papillary thyroid cancer amongst atomic bomb survivors. (23050789)
2012
19
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. (21606412)
2011
20
Current role of metaiodobenzylguanidine in the diagnosis of pheochromocytoma and medullary thyroid cancer. (21803186)
2011
21
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. (22105174)
2011
22
Germline RET sequence variation I852M and occult medullary thyroid cancer: harmless polymorphism or causative mutation? (21711375)
2011
23
Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. (20371662)
2010
24
Thyroid cancers amongst goiter population in a Nigerian tertiary hospital: surgical and radiographic perspective. (21526634)
2010
25
The mitogen-activated protein kinase (MAPK) signaling pathway in papillary thyroid cancer. From the molecular bases to clinical practice]. (19627734)
2009
26
Follicular thyroid cancer cell growth inhibition by proteosome inhibitor MG132. (19552924)
2009
27
Medullary thyroid cancer: molecular biology and novel molecular therapies. (19468197)
2009
28
Ablative free thyroxine to thyroglobulin ratio as a predictor of differentiated thyroid cancer recurrence. (19769825)
2009
29
Genetic aspects of familial thyroid cancer. (19465682)
2009
30
The follow-up of patients with differentiated thyroid cancer and undetectable thyroglobulin (Tg) and Tg antibodies during ablation. (18166820)
2008
31
Fluorodeoxyglucose PET/CT in patients with differentiated thyroid cancer and elevated thyroglobulin after total thyroidectomy and (131)I ablation. (17538522)
2008
32
Dysregulated RET signaling in thyroid cancer. (18502331)
2008
33
Predicting the development of Cushing's syndrome in medullary thyroid cancer: utility of proopiomelanocortin messenger ribonucleic acid in situ hybridization. (17696832)
2007
34
Normocalcemic, subclinical, asymptomatic primary hyperparathyroidism in patients with goiter or papillary thyroid cancer--preliminary report. Normocalcemic primary hyperparathyroidism and thyroid pathology. (17966885)
2007
35
Differential effects of cetuximab and AEE 788 on epidermal growth factor receptor (EGF-R) and vascular endothelial growth factor receptor (VEGF-R) in thyroid cancer cell lines. (17873319)
2007
36
Positive predictive value of detectable stimulated tg during the first year after therapy of thyroid cancer and the value of comparison with Tg-ablation and Tg measured after 24 months. (17123341)
2006
37
Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer. (16263812)
2006
38
Risk of thyroid cancer after childhood exposure to ionizing radiation for tinea capitis. (17018661)
2006
39
Additive antitumor effects of gefitinib and imatinib on anaplastic thyroid cancer cells. (16435154)
2006
40
Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. (15767343)
2005
41
Increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer. (16189643)
2005
42
Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. (15743786)
2005
43
Papillary thyroid cancer with chest metastases only detected using radioactive iodine. (15605906)
2004
44
Treatment of iodine-negative thyroglobulin-positive thyroid cancer: differences in outcome in patients with macrometastases and patients with micrometastases. (15232654)
2004
45
Procedure guidelines for radioiodine therapy of differentiated thyroid cancer (version 2)]. (15316577)
2004
46
Pulmonary epithelioid hemangioendothelioma coexistent with pulmonary metastasis of thyroid cancer. (11518122)
2001
47
Treating the patient with differentiated thyroid cancer with thyroglobulin-positive iodine-131 diagnostic scan-negative metastases: including comments on the role of serum thyroglobulin monitoring in tumor surveillance. (10787191)
2000
48
18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography localizes residual thyroid cancer in patients with negative diagnostic (131)I whole body scans and elevated serum thyroglobulin levels. (10404792)
1999
49
A case of follicular thyroid cancer with tracheal stenosis responded to external radiation therapy. (10378657)
1999
50
Infrequent CDKN2 mutation in human differentiated thyroid cancers. (8561866)
1996

Variations for Thyroid Cancer

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Expression for genes affiliated with Thyroid Cancer

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Expression patterns in normal tissues for genes affiliated with Thyroid Cancer

Search GEO for disease gene expression data for Thyroid Cancer.

Pathways for genes affiliated with Thyroid Cancer

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Pathways related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
EGFR-dependent Endothelin signaling events37
9.9HRAS, EGF, NRAS
2
Show member pathways
9.9HRAS, EGF, NRAS
39.9HRAS, RET, PIK3CA
49.9EGF, HRAS, PIK3CA
5
Show member pathways
9.9HRAS, NRAS, BRAF
69.8PIK3CA, BRAF, HRAS
7
Show member pathways
9.7NRAS, PIK3CA, HRAS, EGF
8
Show member pathways
9.7NRAS, HRAS, BRAF, PIK3CA
99.7NRAS, HRAS, PIK3CA, BRAF
10
Show member pathways
9.7HRAS, EGF, NRAS, BRAF
11
Show member pathways
Immune response IL 4 signaling pathway59
Signal transduction AKT signaling59
9.7HRAS, CDKN1A, PTEN, PIK3CA
12
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells59
Oncostatin M Signaling Pathway37
9.6PPARG, NRAS, HRAS, BRAF
139.6PTEN, BRAF, CDKN1A, HRAS
149.5EGF, RASSF1, BRAF, PIK3CA
159.5PAX8, BRAF, PIK3CA, HRAS
16
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.5CDKN1A, HRAS, PIK3CA, PTEN, NRAS
17
Show member pathways
9.5BRAF, HRAS, RET, NRAS, PIK3CA
18
Show member pathways
9.5NRAS, PIK3CA, EGF, HRAS, BRAF
19
Show member pathways
Immune response BCR pathway59
Fc-epsilon receptor I signaling in mast cells37
9.5NRAS, PIK3CA, PTEN, BRAF, HRAS
20
Show member pathways
Translation Non genomic rapid action of Androgen Receptor59
9.5PTEN, HRAS, CDKN1A, EGF, PIK3CA
21
Show member pathways
9.4HRAS, EGF, NRAS, BRAF, PTEN
22
Show member pathways
9.4NRAS, HRAS, PIK3CA, CDKN1A, BRAF
239.4HRAS, BRAF, NRAS, CDKN1A, PIK3CA
24
Show member pathways
9.4NRAS, PIK3CA, PPARG, BRAF, HRAS
25
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway59
9.4HRAS, PTEN, PIK3CA, BRAF, CDKN1A
269.3PTTG1, PIK3CA, NRAS, CDKN1A, HRAS
279.3PTEN, HRAS, EGF, CDKN1A, NRAS, PIK3CA
28
Show member pathways
9.3CDKN1A, PTEN, HRAS, EGF, NRAS, PIK3CA
29
Show member pathways
9.3PIK3CA, PTEN, NRAS, HRAS, CDKN1A, EGF
30
Show member pathways
9.3EGF, HRAS, CDKN1A, PIK3CA, PTEN, NRAS
31
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
9.3NRAS, HRAS, RET, BRAF, PIK3CA, EGF
32
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
9.2EGF, HRAS, NRAS, BRAF, PTEN, PIK3CA
33
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
9.2PIK3CA, BRAF, NRAS, EGF, HRAS, PTEN
349.2EGF, PIK3CA, PTTG1, PTEN, CDKN1A
359.2NRAS, RASSF1, CDKN1A, HRAS, PTEN, PIK3CA
369.2PIK3CA, CDKN1A, HRAS, BRAF, EGF, NRAS
37
Show member pathways
9.2PIK3CA, BRAF, NRAS, CDKN1A, HRAS, EGF
38
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.2PIK3CA, EGF, BRAF, NRAS, HRAS, CDKN1A
399.2EGF, CDKN1A, NRAS, BRAF, PTEN, HRAS
40
Show member pathways
9.2PIK3CA, HRAS, BRAF, NRAS, EGF, RASSF1
41
Show member pathways
9.2BRAF, PPARG, PTEN, NRAS, EGF, HRAS
429.1BRAF, HRAS, NRAS, RET, PAX8, PPARG
43
Show member pathways
Signal transduction PTEN pathway59
9.0PIK3CA, HRAS, EGF, CDKN1A, NRAS, BRAF
44
Show member pathways
9.0BRAF, HRAS, EGF, CDKN1A, NRAS, PTEN
45
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.0PTEN, PIK3CA, BRAF, NRAS, CDKN1A, HRAS
46
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
9.0PIK3CA, PPARG, PTEN, BRAF, NRAS, EGF
47
Show member pathways
Signaling Pathways in Glioblastoma37
8.8PTEN, NRAS, PIK3CA, EGF, CDKN1A, BRAF
488.7HRAS, PTEN, PIK3CA, BRAF, CALCA, NRAS
49
Show member pathways
8.2KISS1R, HRAS, EGF, PIK3CA, CDKN1A, PTEN
508.0RET, PPARG, HRAS, EGF, CDKN1A, RASSF1

Compounds for genes affiliated with Thyroid Cancer

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Compounds related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1panitumumab44 50 1212.1EGF, BRAF, PTEN
2phenylacetate4410.1HRAS, CDKN1A, PPARG
3mithramycin449.9CDKN1A, PPARG, CALCA
4iodine44 2510.8BRAF, TSHR, TG
5gefitinib44 50 1211.8CDKN1A, EGF, PIK3CA, PTEN
6crcs449.8PTEN, HRAS, RASSF1, BRAF, PIK3CA
7gemcitabine44 50 1211.8PTEN, CDKN1A, EGF, HRAS
8rosiglitazone29 44 50 25 1213.8PPARG, TSHR, CDKN1A, PIK3CA, PTEN
9imatinib44 50 1211.7CDKN1A, PIK3CA, PTEN, BRAF, RET
10phosphotyrosine449.7RET, PIK3CA, HRAS, PTEN, EGF
11lovastatin44 50 60 29 1213.7PTEN, CDKN1A, EGF, HRAS
12calcitriol44 60 25 1212.6EGF, CDKN1A, CALCA, PTEN, TG
13sodium iodide449.6TG, BRAF, PAX8, TSHR, RET, NKX2-1
14thyroxine44 2510.6TG, PAX8, CALCA, TSHR, PPARG
15iodide44 2510.6PIK3CA, TG, BRAF, PAX8, TSHR, NKX2-1
1612-o-tetradecanoylphorbol 13-acetate449.6HRAS, CDKN1A, TSHR, BRAF, RET, EGF
17phosphoinositide449.5BRAF, TSHR, EGF, HRAS, PIK3CA, PTEN
18paclitaxel44 50 1211.5CDKN1A, HRAS, BRAF, PTEN, PIK3CA, EGF
19methionine449.5HRAS, PTEN, TSHR, RET, RASSF1
20aspartate449.5TSHR, PTEN, BRAF, HRAS, TG, RET
21ribonucleic acid449.4TG, PTTG1, RET, PAX8, NKX2-1, TSHR
22pge2449.4PTEN, CALCA, PPARG, CDKN1A, EGF, HRAS
23adenylate449.4CALCA, EGF, TSHR, TG, PIK3CA, HRAS
24pd 98,059449.4HRAS, CDKN1A, BRAF, PTEN, PIK3CA, RET
25wortmannin449.4PIK3CA, EGF, PTEN, CDKN1A, RET, BRAF
26sodium44 2510.4PAX8, TSHR, NKX2-1, HRAS, TG, PIK3CA
27forskolin44 50 1211.4CALCA, TSHR, BRAF, EGF, PAX8, NKX2-1
28rapamycin449.3PIK3CA, EGF, CDKN1A, BRAF, PPARG, PTEN
29arginine449.3TSHR, RET, TG, BRAF, PIK3CA, HRAS
30thymidine44 2510.3HRAS, TSHR, TG, PTTG1, EGF, PIK3CA
31paraffin449.3PTEN, TG, BRAF, RET, CDKN1A, TSHR
32testosterone44 60 25 1212.3PIK3CA, CALCA, PTEN, EGF, RET, TG
33genistein44 29 60 3 25 1214.3EGF, CDKN1A, PTEN, PPARG, PIK3CA, TG
34progesterone44 29 60 25 1213.2CDKN1A, PTEN, HRAS, PIK3CA, BRAF, TSHR
35cyclic amp44 2510.2HRAS, NKX2-1, TSHR, CALCA, RET, EGF
36ly294002449.2RET, PIK3CA, HRAS, EGF, CDKN1A, PTEN
37cisplatin44 50 60 1212.2EGF, PIK3CA, PTEN, HRAS, BRAF, TG
38phosphatidylinositol449.1PIK3CA, PTTG1, PTEN, BRAF, TSHR, RET
39alanine449.0PPARG, KISS1R, RASSF1, RET, TSHR, BRAF
40h2o2449.0PIK3CA, PTEN, TG, CDKN1A, EGF, HRAS
41cysteine448.9TG, TSHR, PTTG1, PTEN, RET, EGF
42oligonucleotide448.7RASSF1, PTEN, BRAF, PAX8, TSHR, RET
43threonine448.5RET, PTEN, BRAF, PAX8, TSHR, HRAS
44agar448.5HRAS, CDKN1A, RASSF1, NRAS, RET, BRAF
45tyrosine448.4BRAF, TG, HRAS, PTEN, TSHR, RET
46retinoic acid44 259.4EGF, CDKN1A, RASSF1, NKX2-1, TSHR, PIK3CA
47calcium44 50 25 1211.4CALCA, KISS1R, PTEN, EGF, HRAS, PIK3CA
48serine448.3HRAS, BRAF, TG, CDKN1A, RASSF1, NKX2-1
49vegf448.2PIK3CA, PTTG1, HRAS, PTEN, TSHR, PPARG
50estrogen448.0PPARG, BRAF, HRAS, EGF, PIK3CA, PTTG1

GO Terms for genes affiliated with Thyroid Cancer

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Cellular components related to Thyroid Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.5PTEN, BRAF, TSHR, NRAS, RASSF1, KISS1R
2cytosolGO:0058298.1HRAS, NNMT, PPARG, PIK3CA, PTTG1, PTEN

Biological processes related to Thyroid Cancer according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Rac protein signal transductionGO:03502210.3NRAS, HRAS
2regulation of synaptic transmission, GABAergicGO:03222810.3HRAS, NRAS
3thyroid-stimulating hormone signaling pathwayGO:03819410.3PAX8, TSHR
4thyroid gland developmentGO:03087810.1NKX2-1, PAX8, TG
5positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.1PTEN, EGF
6MAPK cascadeGO:00016510.1RET, NRAS, HRAS
7endothelial cell migrationGO:04354210.1PIK3CA, PTEN, CALCA
8striated muscle cell differentiationGO:05114610.0HRAS, NRAS
9response to arsenic-containing substanceGO:04668510.0PTEN, CDKN1A
10Ras protein signal transductionGO:00726510.0NRAS, RASSF1, CDKN1A, HRAS
11negative regulation of neuron apoptotic processGO:04352410.0HRAS, NRAS, BRAF, PIK3CA
12leukocyte migrationGO:0509009.9HRAS, NRAS, PIK3CA
13phosphatidylinositol-mediated signalingGO:0480159.9EGF, CDKN1A, PTEN, PIK3CA
14organ regenerationGO:0311009.8NNMT, PPARG, CDKN1A
15positive regulation of cell proliferationGO:0082849.8HRAS, EGF, NRAS, TSHR, PTEN
16activation of MAPKK activityGO:0001869.7BRAF, NRAS, KISS1R, EGF, HRAS
17negative regulation of cell proliferationGO:0082859.7PTEN, RNF139, KISS1R, CDKN1A, HRAS
18Fc-epsilon receptor signaling pathwayGO:0380959.6PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
19epidermal growth factor receptor signaling pathwayGO:0071739.6PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
20positive regulation of transcription, DNA-templatedGO:0458939.5EGF, NKX2-1, RET, PAX8, PPARG
21response to drugGO:0424939.5NNMT, PPARG, PTEN, RET, CDKN1A
22fibroblast growth factor receptor signaling pathwayGO:0085439.4HRAS, PIK3CA, PTEN, BRAF, NRAS, CDKN1A
23innate immune responseGO:0450879.4PPARG, PIK3CA, PTEN, NRAS, CDKN1A, EGF
24neurotrophin TRK receptor signaling pathwayGO:0480119.4PIK3CA, PTEN, BRAF, NRAS, CDKN1A, EGF
25protein phosphorylationGO:0064689.2BRAF, RET, CALCA, CDKN1A

Molecular functions related to Thyroid Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid-stimulating hormone receptor activityGO:00499610.0PAX8, TSHR
2protein bindingGO:0055156.4PPARG, PIK3CA, PTTG1, PTEN, BRAF, PAX8

Products for genes affiliated with Thyroid Cancer

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Sources for Thyroid Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet