Thyroid Cancer malady

MedlinePlus: Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it makes hormones that help the body work normally. anyone can get cancer of the thyroid gland. but certain factors may increase the risk. these include being between ages 25 and 65 being a woman being asian having a family member who has had thyroid disease having radiation treatments to your head or neck you should see a doctor if you have a lump or swelling in your neck. your doctor can order tests to see if you have cancer and, if so, which type. treatment depends on the type and how far the cancer has spread. they include surgery, radioactive iodine, hormone treatment, radiation therapy or chemotherapy. some patients receive a combination of treatments. nih: national cancer institute²³

MalaCards: Thyroid Cancer, also known as thyroid neoplasm, is related to thyroiditis and carcinoma. An important gene associated with Thyroid Cancer is C8orf4 (chromosome 8 open reading frame 4), and among its related pathways are Neurotrophin signaling pathway and Breast Cancer Regulation by Stathmin1. The drugs prednisone and prednisolone tebutate and the compounds estrogen and serine have been mentioned in the context of this disorder. Affiliated tissues include the thryoid gl, whole blood and lymph node, and related mouse phenotypes are growth/size and mortality/aging.

Disease Ontology: An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.⁶

Genetics Home Reference: Multiple endocrine neoplasia is part of a group of disorders that affect the body's network of hormone-producing glands (the endocrine system). Hormones are chemical messengers that travel through the bloodstream and regulate the function of cells and tissues throughout the body. Multiple endocrine neoplasia involves tumors in at least two endocrine glands; tumors can also develop in other organs and tissues. These growths can be noncancerous (benign) or cancerous (malignant). If the tumors become cancerous, some cases can be life-threatening.¹⁷

Wikipedia: Thyroid cancer is a thyroid neoplasm that is malignant. It can be treated with radioactive iodine or...⁴⁴ more...

Aliases & Descriptions:

thyroid cancer 6 8 32 23 thyroid neoplasm 6 43 malignant neoplasm of thyroid gland 6 malignant tumour of thyroid gland 6 malignant neoplasm of thyroid 43

neoplasm of thyroid gland 6 thyroid gland neoplasm 6 malignant neoplasms 43 thyroid neoplasms 32 neoplasms 43

Diseases related to thyroid cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1479)

id	Related Disease	Score	Top Affiliating Genes
1	thyroiditis	64.9	ZNF197, ZNF79, PIK3CA, PIK3R1, PIK3CG, WDR3
2	carcinoma	53.3	ZNF135, ZNF79, PIK3CA, PIK3R1, PIK3CG, LRP1B
3	prostatitis	44.3	ZNF79, PIK3CA, PIK3R1, PIK3CG, LRP1B, LRP2
4	leukemia	41.7	PIK3CA, PIK3R1, PIK3CG, RFC1, NCOA3, KIT
5	melanoma	41.7	PIK3CA, PIK3R1, PIK3CG, NCOA3, RET, KIT
6	adenocarcinoma	41.5	PIK3CA, PIK3R1, PIK3CG, NCOA3, RET, KIT
7	pancreatitis	40.4	PIK3CA, PIK3R1, PIK3CG, LRP2, NCOA3, RET
8	papillary thyroid carcinoma	40.0	NCOA4, RET, SERPINB5, BRAF, VEGFC, RARA
9	cervicitis	39.0	PIK3CA, PIK3CG, RFC1, RET, KIT, PCNA
10	neuronitis	38.8	PIK3CA, PIK3R1, PIK3CG, LRP2, RET, KIT
11	adenoma	37.8	PIK3CA, NCOA3, RET, KIT, KISS1, KISS1R
12	goiter	36.4	RET, BRAF, VEGFA, VEGFC, LMOD1, BGLAP
13	hepatocellular carcinoma	36.3	PIK3CA, PIK3R1, PIK3CG, NCOA3, RET, KIT
14	lung carcinoma	35.9	PIK3CA, PIK3R1, PIK3CG, LRP1B, PCNA, BUB1
15	renal cell carcinoma	35.9	PIK3CA, RET, KIT, KISS1, KISS1R, PCNA
16	gastric cancer	35.7	PIK3CA, PIK3R1, PIK3CG, LRP1B, RFC1, NCOA3
17	thyroid cancer, follicular	35.6	PIK3CA, RASSF1, KDR, CDKN1A, FOS, CALCA
18	thyroid cancer, anaplastic	35.4	PIK3CA, RET, BRAF, RAN, PAX8, BCL2L1
19	breast carcinoma	35.0	PIK3CA, PIK3R1, PIK3CG, NCOA3, KIT, KISS1
20	hepatitis	35.0	PIK3CA, PIK3R1, PIK3CG, NCOA3, KIT, PCNA
21	thyroid carcinoma	34.5	PIK3CA, PIK3CG, RET, PCNA, NBN, VIM
22	sarcoma	34.3	PIK3CA, PIK3R1, PIK3CG, NCOA3, RET, KIT
23	pituitary tumor	33.7	LIF, LGALS3, CHGA, CDKN1B, FGF2, FGFR4
24	multiple endocrine neoplasia	33.6	RET, SDHB, SDHC, SDHD, CHGA, JUN
25	nasopharynx carcinoma	33.4	PIK3CA, PCNA, NAT2, VEGFC, RAF1, RASSF1
26	liver cancer	33.3	PIK3CG, SERPINB5, NAT2, VEGFA, MYC, BMP6
27	tongue cancer	33.2	VEGFC, BCL2L1, LGALS1, CDKN1A, CDH1, MMP2
28	pancreatic cancer	33.1	RET, SERPINB5, VEGFA, RAF1, RAN, RAC1
29	ovarian cancer	32.8	NBN, CDK6, CDKN1A, CDK2, CDKN2B, CDKN1B
30	esophagitis	32.6	PIK3CA, PIK3CG, LRP1B, NCOA3, RET, KIT
31	lung benign neoplasm	32.6	PIK3CG, RARA, RARB, RAF1, RASSF1, KDR
32	autoimmune thyroiditis	32.3	RET, BRAF, LMOD1, LGALS3, CD40, CD55
33	basal cell carcinoma	32.2	RARA, BCL2, LGALS1, LGALS3, BAX, XRCC3
34	hypoxia	32.2	PIK3CA, PIK3R1, PIK3CG, RET, KIT, PCNA
35	myeloid leukemia	32.1	PIK3CA, PIK3R1, PIK3CG, NCOA3, KIT, PCNA
36	hypothyroidism	32.1	LRP2, RET, BRAF, LMOD1, PAX8, LGALS3
37	salivary gland cancer	31.9	KIT, SERPINB5, BIRC2, BIRC5, CFLAR, MMP9
38	brain cancer	31.9	VEGFA, RAD51, BAX, INSR, IL13, ENO2
39	anaplastic carcinoma	31.8	RET, VIM, BRAF, PAX8, LGALS1, LGALS3
40	neuroendocrine tumor	31.7	RET, RAF1, RASSF1, PAX8, SDHD, CHGA
41	multiple endocrine neoplasia type 2a	31.7	RET, SDHB, SDHC, SDHD, MEN1, CALCA
42	ovarian carcinoma	31.7	PIK3CA, PIK3CG, NCOA3, KIT, KISS1, KISS1R
43	pancreatic ductal adenocarcinoma	31.6	SERPINB5, VIM, BRAF, VEGFA, VEGFC, VCP
44	testicular cancer	31.3	NAT2, VEGFC, BMP6, RAC1, LGALS1, B2M
45	paraganglioma	31.2	RET, KIT, PCNA, VIM, LIF, BCL2
46	parathyroid adenoma	31.1	RET, PCNA, GCM2, BGLAP, BCL2, LGALS3
47	myelodysplastic syndrome	31.0	KIT, RARA, RAN, BIRC5, CFLAR, MPO
48	glioblastoma	30.9	PIK3CA, PIK3CG, VEGFA, RAC1, BIRC5, KDR
49	ovarian mucinous neoplasm	30.9	PIK3CA, PCNA, SERPINB5, BRAF, MYC, CHGA
50	b-cell lymphomas	30.8	NBN, MYC, BIRC2, BIRC5, BCL2, BCL2L1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], doxorubicin hydrochloride, interferon alfa-2b, levothyroxine, levothyroxine sodium, linolenic acid, liothyronine, liothyronine sodium, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product], thyroglobulin, thyroid, thyroid pwdr [va product], thyroid,bovine

MalaCards organs/tissues related to thyroid cancer:

²²

FMA organs/tissues related to thyroid cancer:

¹¹

MGI Mouse Phenotypes related to thyroid cancer:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	20.1	PIK3CA, PIK3R1, PIK3CG, LRP2, NCOA3, RET
2	mortality/aging	MP:0010768	17.8	PIK3CA, RET, KISS1, KISS1R, SERPINB5, BRAF
3	homeostasis/metabolism phenotype	MP:0005376	16.5	PIK3CA, PIK3R1, PIK3CG, LRP2, NCOA3, RET
4	nervous system phenotype	MP:0003631	16.1	KIT, KISS1, KISS1R, GCM2, NBN, BRAF
5	embryogenesis phenotype	MP:0005380	15.9	PIK3CA, NCOA3, RET, KIT, BUB1B, GCM2
6	immune system phenotype	MP:0005387	15.7	NCOA3, KIT, KISS1R, BUB1, BUB1B, NBN
7	behavior/neurological phenotype	MP:0005386	15.6	PIK3CA, LRP2, NCOA3, KIT, KISS1R, NBN
8	hematopoietic system phenotype	MP:0005397	15.4	KIT, KISS1R, PCNA, BUB1, BUB1B, NBN
9	integument phenotype	MP:0010771	15.1	PIK3CG, NCOA3, KIT, KISS1, KISS1R, BUB1B
10	cellular phenotype	MP:0005384	15.0	PIK3CA, PIK3R1, PIK3CG, LRP2, NCOA3, RET
11	cardiovascular system phenotype	MP:0005385	15.0	PIK3CA, PIK3R1, PIK3CG, RET, KIT, VIM
12	renal/urinary system phenotype	MP:0005367	14.1	LRP2, NCOA3, RET, KIT, KISS1, KISS1R
13	reproductive system phenotype	MP:0005389	14.0	PIK3CA, NCOA3, RET, KISS1, KISS1R, BUB1
14	digestive/alimentary phenotype	MP:0005381	13.9	LRP2, NCOA3, RET, KIT, KISS1, KISS1R
15	endocrine/exocrine gland phenotype	MP:0005379	13.6	LRP2, RET, KISS1, KISS1R, BUB1, GCM2
16	craniofacial phenotype	MP:0005382	13.4	LRP2, NCOA3, KIT, GCM2, NBN, LPAR1
17	normal phenotype	MP:0002873	13.4	PIK3R1, LRP1B, RET, KISS1R, BUB1, BRAF
18	skeleton phenotype	MP:0005390	12.6	PIK3CG, LRP2, KIT, BUB1B, GCM2, BRAF
19	vision/eye phenotype	MP:0005391	12.2	PIK3CA, LRP2, KIT, BUB1B, VIM, BRAF
20	tumorigenesis	MP:0002006	12.1	PIK3CA, PIK3R1, NCOA3, RET, KIT, BUB1
21	hearing/vestibular/ear phenotype	MP:0005377	12.0	LRP2, NCOA3, KIT, MYC, RARA, RARB
22	respiratory system phenotype	MP:0005388	12.0	LRP2, RET, LPAR2, LIF, LDHA, MT2A
23	no phenotypic analysis	MP:0003012	11.9	PIK3R1, LRP2, RET, PCNA, BUB1, VEGFA
24	limbs/digits/tail phenotype	MP:0005371	11.8	RET, KIT, VEGFA, RARA, RARB, RAC1
25	muscle phenotype	MP:0005369	11.6	PIK3CA, PIK3R1, PIK3CG, NCOA3, RET, KIT
26	pigmentation phenotype	MP:0001186	11.5	KIT, BRAF, MYC, RAC1, BCL2, LEF1
27	liver/biliary system phenotype	MP:0005370	11.4	NCOA3, KIT, BUB1, VEGFA, RASSF2, LIG4
28	other phenotype	MP:0005395	10.3	BUB1, RARA, RARB, KDR, AXIN1, CDKN2A
29	adipose tissue phenotype	MP:0005375	9.7	PIK3CA, PIK3R1, NCOA3, BUB1B, BRAF, LPAR1

Articles related to thyroid cancer:

(show top 50)    (show all 833)

id	Title	Authors	Year	Affiliating Genes
1	Progression of BRAF-induced thyroid cancer is associa ted with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFI^ signaling. (21383698)	Knauf J.A.... Fagin J.A.	2011	BRAF
2	The BRAFV600E mutation: what is it really orchestrati ng in thyroid cancer? (21321384)	Nucera C.... Parangi S.	2010	BRAF
3	Selenium decreases thyroid cancer cell growth by incr easing expression of GADD153 and GADD34. (20043261)	Kato M.A.... Fahey T.J.	2010	DDIT3, PPP1R15A
4	BRAF(V600E) mutation influences hypoxia-inducible fac tor-1alpha expression levels in papillary thyroid cancer. (20473281)	Zerilli M.... Rodolico V.	2010	BRAF, HIF1A
5	Iodine induces apoptosis via regulating MAPKs-related p53, p21, and Bcl-xL in thyroid cancer cells. (20138958)	Liu X.H.... van Hasselt C.A.	2010	CDKN1A
6	WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population. (20578902)	Akdi A.... VelA!zquez A.	2010	WDR3
7	GST genes expression as prognostic factor in papilla ry thyroid cancer (19629346)	GonAsalves A.J.... Nakai M.Y.	2009	GSTT1, GSTM1
8	Detection and identification of specific serum bioma rkers in papillary thyroid cancer (19615280)	Wang J.X.... Zheng S.	2009	APOC1
9	CD133+ anaplastic thyroid cancer cells initiate tumor s in immunodeficient mice and are regulated by thyrotropin. (19404394)	FRIEDMAN S.... Lin R.Y.	2009	PROM1
10	Loss of Rap1GAP in papillary thyroid cancer. (19066305)	Nellore A.... Brose M.S.	2009	RAP1GAP
11	Expression of hepatocyte nuclear factor-1alpha mRNA in human anaplastic thyroid cancer cell lines and tumors. (18399756)	Xu J.... Hershman J.M.	2008	HNF1A, HNF1B
12	High cathepsin K levels in men with differentiated thyroid cancer on suppressive L-thyroxine therapy. (18302515)	Mikosch P.... Pietschmann P.	2008	CTSK
13	Evidence of acute pancreatitis in a patient with radioresistant-differentiated thyroid cancer. (18390021)	Elias A.N.... Hofflich H.	2008	PPARA
14	PET scan valuable in subset of patients with negative I-131 scan, rising thyroglobulin levels in differentiated thyroid cancer patie nts. (18685889)	Ramakant P.... Verma A.K.	2008	TG
15	C8orf4/TC-1 (thyroid cancer-1) gene expression in thyroid cancer and goiter. (17167272)	de Melo Martins P.C.... Garicochea B.	2007	C8orf4
16	Genome-wide expression analysis of Middle Eastern papillary thyroid cancer reveals c-MET as a novel target for cancer therapy. (17703498)	Siraj A.K.... Al-Kuraya K.S.	2007	MET
17	US diagnosis of cervical recurrence in patients opera ted on thyroid cancer: sonographic features and clinical significance. (17270376)	Lee Y.H.... Song J.J.	2007	TG
18	Isotretinoin as a diagnostic tool for localization of thyroid tissue in a thyroid cancer patient: a case report. (17956163)	Coelho S.M.... Vaisman M.	2007	TG
19	Redefining functional sensitivity of thyroglobulin assay on Immulite platform: implications in thyroid cancer management. (17892441)	Giovanella L.... Ghelfo A.	2007	TG
20	Thyroid-stimulating hormone receptor messenger ribonucleic acid measurement in blood as a marker for circulating thyroid cancer cells and its role in the preoperative diagnosis of thyroid cancer. (17118994)	Chia S.Y.... Gupta M.K.	2007	TSHR
21	Erythropoietin in thyroid cancer. (16699298)	Yates C.M.... Francis G.L.	2006	EPOR, EPO, CSN2
22	Pituitary tumor-transforming gene regulates multiple downstream angiogenic genes in thyroid cancer. (16394085)	Kim D.S.... McCabe C.J.	2006	THBS1, ID3, PTTG1
23	TP53 codon 72 polymorphism in radiation-associated human papillary thyroid cancer. (16525684)	Rogounovitch T.I.... Yamashita S.	2006	TP53
24	Acute lymphoblastic leukemia with t(4;11)(q21;q23) after iodine-131 treatment for thyroid cancer (16440804)	Iuchi Y.... Kohgo Y.	2005	MPO
25	Efficacy of epidermal growth factor receptor-targeted molecular therapy in anaplastic thyroid cancer cell lines. (15785737)	Nobuhara Y.... Hirakawa K.	2005	EGF
26	Prognostic significance of successful ablation with radioiodine of differentiated thyroid cancer patients. (15762184)	Verburg F.A.... de Klerk J.M.	2005	TG
27	Altered expression of cyclins and cell cycle inhibitors in papillary thyroid cancer: prognostic implications. (15929668)	Pickett C.A.... Bronner M.P.	2005	CDKN1A, IFI27
28	Epidermal growth factor receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer. (15623643)	Schiff B.A.... Myers J.N.	2004	EGFR, EGF
29	Predictive value for disease progression of serum thy roglobulin levels measured in the postoperative period and after (131)I ablatio n therapy in patients with differentiated thyroid cancer. (15181134)	Toubeau M.... Brunotte F.	2004	TG
30	Redifferentiation therapy in advanced thyroid cancer. (15379720)	Haugen B.R.	2004	RARB
31	Activation of the hepatocyte growth factor (HGF)-Met system in papillary thyroid cancer: biological effects of HGF in thyroid cancer cells depend on Met expression levels. (15192042)	Mineo R.... Belfiore A.	2004	MET, HGF
32	Interleukin-4 stimulates papillary thyroid cancer cell survival: implications in patients with thyroid cancer and concomitant Graves' disease. (15181072)	Vella V.... Belfiore A.	2004	IL4
33	Treatment of iodine negative, thyroglobulin positive, thyroid cancer patients: do we miss the target when we shoot in the dark? (12813190)	Kabasakal L.	2003	TG
34	18F-FDG-PET in the follow-up of thyroid cancer. (12558561)	Lind P.... Gomez I.	2003	TG
35	The helix-loop-helix protein, Id-1, is overexpressed and regulates growth in papillary thyroid cancer. (12947323)	Kebebew E.... Clark O.H.	2003	ID1
36	Kinetics of iodide uptake and efflux in various human thyroid cancer cells by expressing sodium iodide symporter gene via a recombinant adenovirus. (12792733)	Lee W.W.... Lee H.	2003	TPO, TSHR
37	Quantitative detection of peripheral thyroglobulin mRNA has limited clinical value in the follow-up of thyroid cancer patients. (12542917)	Span P.N.... Sweep C.G.	2003	TG
38	Determination of galectin-3 messenger ribonucleic Acid overexpression in papillary thyroid cancer by quantitative reverse transcription-polymerase chain reaction. (12364475)	Bernet V.J.... Ringel M.D.	2002	GAPDH, LGALS3
39	Multigenerational familial medullary thyroid cancer (FMTC): evidence for FMTC phenocopies and association with papillary thyroid cancer. (11849247)	Fugazzola L.... Beck-Peccoz P.	2002	RET
40	Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells. (11994395)	Ringel M.D.... Saji M.	2002	MAPK1, MAPK10, KISS1R
41	Characterization of a thyroid hormone-mediated short-loop feedback control of TSH receptor gene in an anaplastic human thyroid cancer cell line. (12429043)	Chen S.T.... Lin K.H.	2002	THRB, TSHR
42	Radiopeptide transmitted internal irradiation of non-iodophil thyroid cancer and conventionally untreatable medullary thyroid cancer using. (11403179)	Waldherr C.... Mueller-Brand J.	2001	SST
43	Transcriptional activation of the thyroglobulin promoter directing suicide gene expression by thyroid transcription factor-1 in thyroid cancer cells. (11325833)	Shimura H.... Onaya T.	2001	PAX8, TG, FOXE1
44	18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography localizes residual thyroid cancer in patients with negative diagnostic (131)I whole body scans and elevated serum thyroglobulin levels. (10404792)	Wang W.... Robbins R.J.	1999	TG
45	Loss of heterozygosity of the long arm of chromosome 7 in follicular and anaplastic thyroid cancer, but not in papillary thyroid cancer. (10487693)	Trovato M.... Benvenga S.	1999	MET, HGF
46	Possible relation of osteopontin to development of psammoma bodies in human papillary thyroid cancer. (9870857)	Tunio G.M.... Kitamura Y.	1998	SPP1
47	Evaluation and treatment of persistent thyroglobulinemia in patients with well-differentiated thyroid cancer. (9330589)	Pachucki J.... Burmeister L.A.	1997	TG
48	Expression of p21 ras protein as a prognostic factor in papillary thyroid cancer. (7908818)	Basolo F.... Pacini F.	1994	CDKN1A
49	Transforming growth factor-beta 1 is a negative regulator for differentiated thyroid cancer: studies of growth, migration, invasion, and adhesion of cultured follicular and papillary thyroid cancer cell lines. (8077365)	HAPlting T.... Duh Q.Y.	1994	EGF, TGFB1
50	Follow-up study of postoperative patients with thyroid cancer by thallium-201 scintigraphy and serum thyroglobulin measurement. (1941144)	Iida Y.... Konishi J.	1991	TG

Genes related to thyroid cancer according to GeneCards:

(show top 50)    (show all 441)

id	Symbol	Description	Score	GeneCards Section Context
1	C8orf4	chromosome 8 open reading frame 4	11.1	Publications, Summaries, Aliases & Descriptions
2	NKX2-1	NK2 homeobox 1	11.0	Summaries, Publications
3	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.0	Pathways & Interactions, Publications, Summaries
4	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	11.0	Publications, Pathways & Interactions, Summaries
5	RNF139	ring finger protein 139	11.0	Summaries
6	ITIH5	inter-alpha-trypsin inhibitor heavy chain family, member 5	11.0	Summaries
7	TG	thyroglobulin	11.0	Publications
8	TSHR	thyroid stimulating hormone receptor	11.0	Publications
9	RET	ret proto-oncogene	11.0	Publications, Pathways & Interactions
10	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0	Publications
11	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	11.0	Publications
12	PTEN	phosphatase and tensin homolog	11.0	Publications
13	EGF	epidermal growth factor	11.0	Publications
14	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
15	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Pathways & Interactions, Publications
16	NNMT	nicotinamide N-methyltransferase	11.0	Publications
17	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0	Pathways & Interactions, Publications
18	PAX8	paired box 8	11.0	Pathways & Interactions, Publications
19	KISS1R	KISS1 receptor	11.0	Publications
20	PTTG1	pituitary tumor-transforming 1	11.0	Publications
21	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
22	TPO	thyroid peroxidase	11.0	Publications
23	CCDC6	coiled-coil domain containing 6	11.0	Publications, Pathways & Interactions
24	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
25	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	11.0	Publications
26	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	11.0	Pathways & Interactions, Publications
27	MAPK10	mitogen-activated protein kinase 10	11.0	Publications
28	VEGFC	vascular endothelial growth factor C	11.0	Publications
29	MET	met proto-oncogene (hepatocyte growth factor receptor)	11.0	Publications
30	THRB	thyroid hormone receptor, beta	11.0	Publications
31	SLC5A5	solute carrier family 5 (sodium iodide symporter), member 5	10.9	Publications
32	NCOA4	nuclear receptor coactivator 4	10.9	Pathways & Interactions, Publications
33	ECM1	extracellular matrix protein 1	10.9
34	KISS1	KiSS-1 metastasis-suppressor	10.9	Publications
35	ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	10.9	Publications
36	ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	10.9	Publications
37	THRA	thyroid hormone receptor, alpha	10.9	Publications
38	CCKBR	cholecystokinin B receptor	10.9	Publications
39	IBSP	integrin-binding sialoprotein	10.9	Publications
40	SERPINB5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	10.9	Publications
41	HNF1B	HNF1 homeobox B	10.9	Publications
42	TIMP3	TIMP metallopeptidase inhibitor 3	10.9	Publications
43	EFNB2	ephrin-B2	10.9
44	SLC26A4	solute carrier family 26, member 4	10.9	Publications
45	S100A1	S100 calcium binding protein A1	10.9	Publications
46	GSTT1	glutathione S-transferase theta 1	10.9	Publications
47	GSTM1	glutathione S-transferase mu 1	10.9	Publications
48	EPOR	erythropoietin receptor	10.9	Publications
49	PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha	10.9	Publications
50	PRDX5	peroxiredoxin 5	10.9

Pathways related to thyroid cancer according to GeneDecks:

(show top 50)    (show all 372)

id	Pathway	Score	Top Affiliating Genes
1	Neurotrophin signaling pathway20	12.2	PIK3CA, PIK3CG, BRAF, RAF1, RAC1, BAX
2	Breast Cancer Regulation by Stathmin136	12.2	PIK3R1, RAF1, RAC1, AXL, MST1R, FGF1
3	Integrin Pathway36	12.2	PIK3R1, BRAF, MYC, RAF1, RAC1, JUN
4	FAK1 Signaling36	12.1	PIK3R1, BRAF, RAF1, RAC1, ITGAL, ITGB1
5	Thyroid cancer20	12.1	NCOA4, RET, BRAF, MYC, PAX8, LEF1
6	Paxillin Interactions36	12.0	PIK3R1, KIT, VEGFC, RAC1, KDR, AXL
7	Endometrial cancer20	12.0	PIK3CA, PIK3R1, PIK3CG, BRAF, MYC, RAF1
8	Glioma20	11.9	PIK3CA, PIK3R1, PIK3CG, BRAF, RAF1, MTOR
9	p53 Signaling36	11.8	BCL2, BAX, CDKN1A, FOS, MDM2, MAPK10
10	Development_Neurotrophin family signaling41	11.8	PIK3CA, PIK3R1, BRAF, RAF1, RAC1, BAX
11	Development_PDGF signaling via MAPK cascades41	11.8	PIK3CA, PIK3R1, RAF1, RAC1, JUN, MAP2K2
12	Development FGFR signaling pathway10	11.7	PIK3CA, PIK3R1, RAF1, RAC1, JUN, FGF2
13	cAMP Pathway36	11.6	PIK3R1, KIT, BRAF, VEGFC, BMP6, RAF1
14	Transcription PPAR Pathway10	11.6	PIK3CA, PIK3R1, RAF1, MED1, MAPK3, MAPK14
15	Development EGFR signaling via small GTPases10	11.6	PIK3CA, PIK3R1, MYC, RAF1, RAC1, FOS
16	Development CNTF receptor signaling10	11.6	PIK3CA, PIK3R1, MTOR, FOS, MAP2K2, MAPK3
17	Development_HGF signaling pathway41	11.5	PIK3CA, PIK3R1, RAF1, RAC1, JUN, CDH1
18	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	11.5	PIK3CA, PIK3R1, RAF1, BCL2, BAX, JUN
19	Development Prolactin receptor signaling10	11.5	PIK3CA, PIK3R1, MYC, RAF1, RAC1, BCL2
20	MAPK Signaling36	11.5	PIK3R1, KIT, BRAF, VEGFC, MYC, BMP6
21	Apoptosis and Autophagy3	11.5	SERPINB5, MYC, BIRC2, BIRC5, BCL2, BCL2L1
22	JAK-STAT Pathway36	11.5	PIK3R1, KIT, VEGFC, MYC, BMP6, RAF1
23	Development Flt3 signaling10	11.4	PIK3CA, PIK3R1, RAF1, RAC1, BCL2L1, JUN
24	ERK Signaling36	11.4	PIK3R1, KIT, BRAF, VEGFC, MYC, BMP6
25	Activation of cAMP-Dependent PKA36	11.4	VEGFC, RAF1, KDR, AXL, MST1R, ATF1
26	Rac1 Pathway36	11.4	PIK3R1, BMP6, RAF1, RAC1, KDR, JUN
27	TGF-Beta Pathway36	11.4	PIK3R1, VEGFC, BMP6, KDR, BCL2, BAX
28	Regulation of actin cytoskeleton20	11.3	PIK3R1, BRAF, RAF1, ITGAL, ITGB1, FN1
29	IP3 Pathway36	11.3	PIK3R1, VEGFC, BMP6, KDR, FLT4, FGF1
30	Cytoskeleton remodeling_Integrin outside-in signaling41	11.2	RAF1, RAC1, LEF1, JUN, ITGB1, FN1
31	Cell Cycle / Checkpoint Control3	11.2	PCNA, BUB1B, NBN, VCP, RAD51, RAD52
32	Renal cell carcinoma20	11.2	PIK3R1, RAF1, RAC1, JUN, MET, MAP2K2
33	Development_Endothelin-1/EDNRA signaling41	11.1	RAC1, MAPK14, MAPK10, CCND1, GNAQ, GNAS
34	Pancreatic Adenocarcinoma36	11.1	PIK3R1, KIT, BRAF, VEGFC, BMP6, RAF1
35	Antioxidant Action of Vitamin-C36	11.1	KIT, VEGFC, BMP6, RAC1, LIF, KDR
36	Pathway_PA16598005034	11.1	BRAF, MYC, RAF1, KDR, JUN, FLT4
37	p53 Mediated Apoptosis36	11.1	PIK3R1, KIT, VEGFC, BMP6, KDR, BCL2
38	Pancreatic cancer20	11.0	CDK6, AKT2, AKT3
39	Actin-Based Motility by Rho Family GTPases36	10.9	ITGAL, FGFR4, IL2, IGF1, CTGF, NTRK1
40	Development IGF-RI signaling10	10.9	PIK3CA, PIK3R1, MYC, RAF1, BCL2L1, MTOR
41	Signal transduction AKT signaling10	10.8	PIK3R1
42	Endothelin-1 Signaling Pathway36	10.8	PIK3R1, KIT, BRAF, MYC, BMP6, RAF1
43	Cell cycle20	10.8	PCNA, BUB1, BUB1B, MYC, CDK6, CDKN1A
44	Toll-like receptor signaling pathway20	10.8	PIK3CA, PIK3R1, PIK3CG, RAC1, JUN, CD40
45	MAPK signaling pathway20	10.7	BRAF, MYC, RAF1, RAC1, JUN, FOS
46	p70S6K Signaling36	10.7	PIK3R1, KIT, VEGFC, BMP6, RAF1, RAC1
47	Cellular Apoptosis Pathway36	10.1	PIK3R1, KIT, VEGFC, BMP6, BIRC2, KDR
48	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	9.9	MYC, RAF1, BCL2, BAX, JUN, FOS
49	T cell receptor signaling pathway20	9.7	PIK3CA, PIK3R1, PIK3CG, RAF1, JUN, CD40LG
50	Cytokine-cytokine receptor interaction20	9.3	KIT, VEGFA, VEGFC, LIF, KDR, CD40LG

Compounds related to thyroid cancer according to GeneDecks:

(show top 50)    (show all 428)

id	Compound	Score	Top Affiliating Genes
1	estrogen32	15.9	PIK3R1, NCOA3, NCOA4, KISS1, PCNA, SERPINB5
2	serine32	15.0	PIK3CA, PIK3R1, PIK3CG, LRP2, RET, KIT
3	vegf32	14.5	PIK3CA, PIK3R1, PIK3CG, RET, KIT, PCNA
4	adenylate32	13.4	PIK3CA, PIK3CG, VIM, RARB, CHKA, CHGA
5	dopamine32 9 18 9	16.0	PIK3CA, RET, LMOD1, BMP6, RARB, RAF1
6	h2o232	12.8	PIK3R1, PIK3CG, RAD51, RAN, LIF, BGLAP
7	arginine32	12.4	PIK3CA, RFC1, NCOA3, RET, BRAF, LPAR1
8	nmda32 42	13.3	PIK3CA, KISS1R, VIM, BCL2L1, SDHB, CDKN3
9	retinoid32	12.3	NCOA3, VIM, MYC, BMP6, RARA, RARB
10	guanine32 9 18 9	15.2	RAD51, RAF1, RAC1, BIRC5, CHGA, UGT1A1
11	glyceraldehyde 3-phosphate32	12.2	KISS1, KISS1R, VEGFC, BIRC5, SDHB, LGALS1
12	12-o-tetradecanoylphorbol 13-acetate32	12.1	RET, BRAF, MYC, BMP6, RARA, RARB
13	phospholipid32	12.0	PIK3R1, LRP2, LPAR1, LPAR2, MUC1, S100A1
14	camptothecin32 42 9 9	14.7	PIK3CG, PCNA, NBN, MYC, RAD51, RAD52
15	fatty acid32	11.6	BRAF, LPAR2, LGALS3, CHKA, CDKN1B, CDKN2A
16	pkcs32	11.5	PIK3R1, PIK3CG, RAF1, P2RY2, FOS, MBP
17	inositol32	11.5	CHGA, P2RY2, INSR, FGF1, MBP, HSPG2
18	nacl32	11.4	RAD51, LIG4, LIF, XRCC5, S100A1, P2RX7
19	leptomycin b32	11.4	RAN, BIRC5, LGALS3, CDKN1A, CDKN1B, CDH1
20	u012632 42	12.3	PIK3CG, JUN, MMP1, MAP2K2, MAPK14, MAPK10
21	sp 60012532 42	12.3	PIK3CG, BIRC2, CDKN1A, CD40, MMP1, IL13
22	rottlerin32 42	12.3	PIK3R1, PIK3CG, RAC1, JUN, CDK6, CD40LG
23	phenylalanine32	11.2	PIK3R1, UGT1A1, ASCL1, INSR, MC1R, HNF1A
24	phosphatidylcholine32	11.2	VIM, RAF1, RAC1, CHKA, ITGB1, FN1
25	acth32	11.2	LGALS3, MUC1, CEACAM1, INS, IL1RN, APC
26	hematoxylin32	11.1	KIT, PCNA, VIM, LGALS3, CHKA, CHGA
27	1,25 dihydroxy vitamin d332	11.1	MYC, BMP6, RARA, RAF1, LIF, BGLAP
28	creatinine32	11.1	PCNA, BMP6, SDHB, CHKA, CHGA, MUC1
29	etoposide32 42 9 9	14.0	PIK3CA, PIK3R1, PIK3CG, PCNA, MYC, RARA
30	geldanamycin32 9 9	12.9	PIK3R1, PIK3CG, BRAF, VEGFA, RAF1, BIRC5
31	cytochalasin d32 42	11.9	PIK3CG, VIM, RAF1, RAC1, CGA, CDKN3
32	ag 147832	10.9	PIK3CA, PIK3CG, RAF1, JUN, CDK2, CDKN1B
33	chloramphenicol32 9 9	12.9	NCOA4, VIM, MYC, RARA, RARB, RAF1
34	pd15303532	10.8	PIK3CG, VEGFA, BIRC5, JUN, MMP1, MAPK14
35	ibmx32	10.8	RARB, RAF1, CGA, CDK2, CDKN3, MMP2
36	quercetin32 42 9 18 9	14.6	PIK3CA, PIK3R1, PIK3CG, RAF1, BIRC5, BCL2
37	butyrate32	10.6	NCOA3, RET, PCNA, VIM, MYC, BMP6
38	sodium dodecylsulfate32	10.3	MYC, BMP6, RAF1, LGALS3, CDH1, MMP1
39	hydroxyproline32 18	11.2	BMP6, BGLAP, ITGB1, MMP1, MMP2, MMP9
40	5fluorouracil32	10.2	PIK3CA, PIK3CG, KIT, PCNA, VEGFA, LIF
41	losartan32 34 9 9	13.2	PCNA, BMP6, UGT1A1, MMP1, FOS, MAPK3
42	doxycycline32 9 9	12.0	CDK2, CDKN2B, CDKN2A, CD40LG, MMP1, MMP2
43	prostacyclin32	9.7	VEGFA, BMP6, KDR, CGA, FN1, INSR
44	sulindac32 9 9	11.7	PCNA, BIRC5, BCL2, BCL2L1, BAX, CDKN1A
45	infliximab32 9 9	11.6	VEGFA, BGLAP, MMP1, MMP3, FGF2, IL10
46	troglitazone32 42 9 9	12.3	PIK3CG, BMP6, RARA, BIRC5, BCL2, UGT1A1
47	alpha tocopherol32	9.1	RARB, LIF, BGLAP, CHKA, CDKN3, ITGAL
48	actinomycin d32	9.0	PIK3CA, PIK3CG, KIT, VIM, VEGFA, MYC
49	folate32	9.0	LRP2, VIM, NAT2, MYC, RARA, RASSF1
50	tacrolimus32 34 9 9	11.8	PIK3CA, PCNA, MYC, BMP6, RAF1, MTOR

Cellular components related to thyroid cancer according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	17.5	ZNF197, ZNF135, ZNF79, WDR3, NCOA3, NCOA4
2	cytoplasm	GO:005737	16.4	PIK3CG, NCOA3, KIT, PCNA, BUB1B, SERPINB5
3	cytosol	GO:005829	15.2	PIK3CA, PIK3R1, PIK3CG, BUB1, BUB1B, VIM
4	plasma membrane	GO:005886	15.1	PIK3R1, PIK3CG, LRP2, KIT, KISS1R, VIM
5	nucleoplasm	GO:005654	13.0	RFC1, NCOA3, PCNA, RBBP4, NBN, MYC
6	perinuclear region of cytoplasm	GO:048471	12.2	BUB1B, RAD51, MT2A, MT1G, XRCC3, AXIN1
7	extracellular region	GO:005576	11.8	KISS1, VEGFA, VEGFC, BGLAP, KDR, CHGA
8	mitochondrion	GO:005739	11.8	RAD51, PARK7, BCL2, BCL2L1, SDHB, SDHC
9	integral to plasma membrane	GO:005887	11.1	RET, LPAR1, LPAR2, KDR, UGT1A1, MUC1
10	cell surface	GO:009986	10.4	KISS1R, VEGFA, LPAR1, LPAR2, RARA, LGALS1
11	platelet alpha granule lumen	GO:031093	9.7	VEGFA, VEGFC, FN1, IGF1, ALB, PDGFA
12	external side of plasma membrane	GO:009897	9.3	KIT, KDR, P2RX7, B2M, CD40LG, CD40
13	extracellular space	GO:005615	8.9	LRP2, KIT, SERPINB5, VEGFA, VEGFC, BMP6

Biological processes related to thyroid cancer according to GeneDecks:

(show top 50)    (show all 69)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	13.4	RET, KIT, VEGFC, RAP1GAP, RARA, RASSF2
2	apoptotic process	GO:006915	12.8	BUB1, BUB1B, NBN, VIM, RAF1, RAC1
3	angiogenesis	GO:001525	12.5	PIK3CA, PIK3CG, VEGFA, VEGFC, KDR, CEACAM1
4	fibroblast growth factor receptor signaling pathway	GO:008543	12.1	PIK3CA, PIK3R1, BRAF, RAF1, MTOR, CDKN1B
5	heart development	GO:007507	12.0	PCNA, RAF1, ID1, ID3, GNAQ, CASP3
6	small molecule metabolic process	GO:044281	12.0	PIK3CA, PIK3R1, PIK3CG, LRP2, NCOA3, NAT2
7	nerve growth factor receptor signaling pathway	GO:048011	12.0	PIK3CA, PIK3R1, BRAF, RAF1, RAC1, MTOR
8	response to organic cyclic compound	GO:014070	11.7	LEF1, UGT1A1, P2RX7, MSH2, ATF1, JUN
9	organ regeneration	GO:031100	11.7	LRP2, LIF, LEF1, UGT1A1, CDKN1A, MKI67
10	epidermal growth factor receptor signaling pathway	GO:007173	11.6	PIK3CA, PIK3R1, RAF1, MTOR, CDKN1B, MDM2
11	negative regulation of cell proliferation	GO:008285	11.5	KISS1R, RBBP4, RARB, RAF1, LIF, JUN
12	blood coagulation	GO:007596	11.5	PIK3CA, PIK3R1, PIK3CG, VEGFA, VEGFC, RAF1
13	negative regulation of transcription from RNA polymerase II promoter	GO:000122	11.4	MYC, RARB, LEF1, S100A1, FOXE1, FGFR1
14	cell cycle arrest	GO:007050	11.4	NBN, MYC, RASSF1, MSH2, CDK6, CDKN1A
15	aging	GO:007568	11.4	LRP2, P2RY1, P2RY2, JUN, FAS, CALCA
16	positive regulation of cell proliferation	GO:008284	11.3	KIT, NBN, VEGFA, VEGFC, MYC, RARA
17	cell proliferation	GO:008283	11.3	LRP2, PCNA, BUB1, BUB1B, NBN, RAF1
18	Ras protein signal transduction	GO:007265	11.2	RAF1, RASSF1, CDKN1A, CDK2, CDKN2A, FGF2
19	positive regulation of fibroblast proliferation	GO:048146	11.2	MYC, LIG4, XRCC4, JUN, CDK6, CDKN1A
20	negative regulation of transcription, DNA-dependent	GO:045892	11.1	RARA, BIRC5, LEF1, CITED1, XRCC5, JUN
21	positive regulation of ERK1 and ERK2 cascade	GO:070374	11.1	BRAF, KDR, P2RY1, CD44, FLT4, FGF2
22	negative regulation of neuron apoptotic process	GO:043524	11.1	BRAF, LIG4, PARK7, BCL2, BCL2L1, CITED1
23	activation of MAPKK activity	GO:000186	11.1	KISS1R, RAF1, MAP2K2, NTRK1, NRAS
24	positive regulation of MAPK cascade	GO:043410	10.9	KIT, LPAR1, LPAR2, LIF, KDR, P2RX7
25	positive regulation of transcription, DNA-dependent	GO:045893	10.9	NCOA3, NCOA4, RET, MYC, RARA, RAN
26	platelet activation	GO:030168	10.8	PIK3CA, PIK3R1, PIK3CG, VEGFA, VEGFC, RAF1
27	phosphatidylinositol-mediated signaling	GO:048015	10.8	PIK3CA, PIK3R1, PCNA, BUB1B, MTOR, AURKA
28	transcription initiation from RNA polymerase II promoter	GO:006367	10.7	MYC, RARA, RARB, CDKN2B, MED1, MEN1
29	insulin receptor signaling pathway	GO:008286	10.7	PIK3CA, PIK3R1, RAF1, MTOR, INS, INSR
30	positive regulation of cell migration	GO:030335	10.7	RET, VEGFA, KDR, LEF1, CGA, ITGB1
31	protein autophosphorylation	GO:046777	10.7	KIT, KDR, MTOR, AURKA, FLT4, FLT3
32	cell-cell signaling	GO:007267	10.6	CGA, CD97, INS, INSL3, FGFR2, IL10
33	positive regulation of peptidyl-serine phosphorylation	GO:033138	10.5	PIK3CA, BRAF, VEGFA, RAF1, LIF, BCL2
34	response to ethanol	GO:045471	10.5	BGLAP, BCL2, MMP9, INSR, IL13, IL4
35	positive regulation of transcription from RNA polymerase II promoter	GO:045944	10.4	NCOA3, VEGFA, MYC, BMP6, RARA, RARB
36	activation of MAPK activity	GO:000187	10.4	KIT, LPAR1, LPAR2, P2RX7, INSR, FGF2
37	negative regulation of apoptotic process	GO:043066	10.3	PIK3CG, GCM2, BRAF, VEGFA, MYC, RAF1
38	positive regulation of protein phosphorylation	GO:001934	10.3	VEGFA, MTOR, P2RY1, AXIN1, CD40, FLT4
39	inflammatory response	GO:006954	10.3	PIK3CG, KIT, BMP6, RAC1, PARK7, P2RX7
40	positive regulation of MAP kinase activity	GO:043406	10.2	PIK3CG, VEGFA, MST1R, CD40, FLT3, FGFR1
41	positive regulation of apoptotic process	GO:043065	10.2	LPAR1, RARB, BAX, P2RX7, ITGB1, MMP9
42	positive regulation of DNA replication	GO:045740	10.2	ATF1, JUN, INS, INSR, MET, IL3
43	MAPK cascade	GO:000165	10.1	RET, MYC, RAF1, INS, FGFR1, MEN1
44	response to drug	GO:042493	10.0	LRP2, NBN, VEGFC, MYC, BGLAP, PARK7
45	induction of apoptosis	GO:006917	10.0	BAX, CDKN1B, CDKN2A, FASLG, FAS, MAPK1
46	response to glucocorticoid stimulus	GO:051384	9.7	BGLAP, INSR, IL10, IL1RN, FAS, ANXA3
47	response to hypoxia	GO:001666	9.5	VEGFA, RAF1, BCL2, MMP9, FAS, ANGPT2
48	positive regulation of protein kinase B signaling cascade	GO:051897	9.5	PIK3CG, MTOR, AXL, MST1R, INS, INSR
49	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	VEGFA, LIF, MTOR, CD44, ITGB1, INS
50	anti-apoptosis	GO:006916	9.3	PIK3CA, BRAF, BIRC2, BIRC5, BCL2, BCL2L1

Molecular functions related to thyroid cancer according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	17.5	EPOR, GADD45G, GADD45GIP1, GAPDH, GAS6, JUN
2	ATP binding	GO:005524	13.2	RPS6KB1, ADCY10, ADCY1, NDUFA13, EGFR, ABCC1
3	sequence-specific DNA binding transcription factor activity	GO:003700	12.0	HIF1A, WT1, NFKB1, RXRB, RXRA, NOTCH1
4	receptor binding	GO:005102	11.5	GFRA1, GFRA3, PRDX5, CXCL1, CXCL10, CXCL12
5	protein homodimerization activity	GO:042803	11.4	KIT, VEGFA, RAP1GAP, BIRC5, PARK7, BCL2
6	transcription factor binding	GO:008134	11.2	CTNNB1, HIF1A, TWIST1, THRA, TCF3, TCF7L2
7	protein heterodimerization activity	GO:046982	11.1	ATF1, ITGAL, ITGB1, MET, MCL1, ENO2
8	protein tyrosine kinase activity	GO:004713	11.1	IGF1R, ERBB2, TEK, SRC, SHC1, EGFR
9	transcription regulatory region DNA binding	GO:044212	10.9	TNF, CTNNB1, PPARG, RXRA, RXRB, NFKB1
10	transmembrane receptor protein tyrosine kinase activity	GO:004714	10.8	TYRO3, EGFR, NTRK1, TEK, ERBB2, ALK
11	steroid hormone receptor activity	GO:003707	10.8	RXRA, RXRB, RXRG, THRA, THRB, PGR
12	identical protein binding	GO:042802	10.6	TFG, SLC2A1, ADIPOQ, EPOR, IGF1R, HSP90AA1
13	enzyme binding	GO:019899	10.5	RARA, RAC1, PPARG, NOTCH1, RXRA, WWOX
14	hormone activity	GO:005179	9.8	SST, TSHB, TG, POMC, ADIPOQ, EPO
15	growth factor activity	GO:008083	9.8	PDGFA, PDGFB, EGF, TYMP, TGFA, TGFB1