MCID: THY028
MIFTS: 73

Thyroid Cancer malady

Cancer diseases, Endocrine diseases categories

Summaries for Thyroid Cancer

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Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it makes hormones that help the body work normally. there are several types of cancer of the thyroid gland. you are at greater risk if you are between ages 25 and 65 are a woman are asian have a family member who has had thyroid disease have had radiation treatments to your head or neck you should see a doctor if you have a lump or swelling in your neck. doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose thyroid cancer. treatment depends on the type of cancer you have and how far the cancer has spread. many patients receive a combination of treatments. they may include surgery, radioactive iodine, hormone treatment, radiation therapy, chemotherapy, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Thyroid Cancer, also known as thyroid carcinoma, is related to thyroiditis and goiter. An important gene associated with Thyroid Cancer is NKX2-1 (NK2 homeobox 1), and among its related pathways are EGFR Transactivation by Gastrin and SHC1 events in ERBB2 signaling. The drugs interferon alfa-2b and thyroglobulin and the compounds panitumumab and phenylacetate have been mentioned in the context of this disorder. Affiliated tissues include the thryoid gl, thyroid and testes, and related mouse phenotypes are muscle and adipose tissue.

Disease Ontology:9 An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.

Wikipedia:66 Thyroid cancer is a cancer originating from follicular or parafollicular thyroid cells. more...

Aliases & Classifications for Thyroid Cancer

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 41NCIt, 28ICD9CM, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

thyroid cancer 9 11 46 35
thyroid carcinoma 9 46 63
thyroid neoplasm 9 63
malignant neoplasm of thyroid gland 9
malignant tumour of thyroid gland 9
head and neck cancer, thyroid 9
malignant neoplasm of thyroid 63
neoplasm of thyroid gland 9
thyroid gland neoplasm 9


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Disease Ontology9 DOID:1781, DOID:3963
NCIt41 C7510, C4815
ICD9CM28 193
MeSH36 D013964
ICD1026 C73

Related Diseases for Thyroid Cancer

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Thyroid Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 321)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis32.4TG, TSHR, CALCA
2goiter31.0TG, BRAF, PAX8, TSHR, RET, CALCA
3graves' disease30.8TG, PAX8, TSHR, NKX2-1
4multiple endocrine neoplasia30.7TG, RET, CALCA
5multinodular goiter30.7CALCA, TSHR, TG
6struma ovarii30.7TG, TSHR, NKX2-1
7thyroid carcinoma, follicular, somatic30.6PTEN, NRAS, HRAS
8nodular goiter30.5TG, BRAF, TSHR, RET, CALCA, HRAS
9endemic goiter30.5TG, TSHR
10hypothyroidism30.5NKX2-1, TSHR, TG
11papillary carcinoma30.5PAX8, TSHR, RET, CALCA, NKX2-1, HRAS
12familial adenomatous polyposis30.5PPARG, BRAF, NRAS, RASSF1
13papillary thyroid carcinoma30.5EGF, CDKN1A, KISS1R, NNMT, PPARG, PIK3CA
14thyrotoxicosis30.5TG, TSHR
15pituitary adenoma30.5RET, PTTG1, PPARG
16retinoblastoma30.4PPARG, PIK3CA, RASSF1, CDKN1A, EGF, HRAS
17autoimmune thyroiditis30.4TG, CALCA
18thyroid medullary carcinoma30.4NKX2-1, CALCA, RET, BRAF, TG
19paraganglioma30.4TG, RET, CALCA
20adenocarcinoma30.4PIK3CA, PTTG1, PTEN, BRAF, NKX2-1, RASSF1
21follicular thyroid carcinoma30.4PPARG, PTEN, TG, BRAF, PAX8, TSHR
22melanoma30.3PIK3CA, PTEN, BRAF, TSHR, NKX2-1, NRAS
23leukemia30.3PIK3CA, PTTG1, TSHR, NRAS, CDKN1A, EGF
24lung adenocarcinoma30.2PIK3CA, BRAF, NKX2-1, RASSF1, CDKN1A, EGF
25neuroma30.2RET, CALCA
26neuroendocrine tumor30.2PAX8, RET, CALCA, NKX2-1, RASSF1
27adenoma30.2PPARG, PTTG1, TG, BRAF, PAX8, TSHR
28familial medullary thyroid carcinoma30.2RET, CALCA
29breast cancer30.2PIK3CA, PTTG1, PTEN, NKX2-1, RASSF1, CDKN1A
30thyroid cancer, anaplastic30.2PAX8, TSHR, RET, CALCA, NKX2-1, CDKN1A
31cowden syndrome 130.1PTEN
32myxedema30.1TSHR, TG
33thyroid adenoma30.0PPARG, PIK3CA, PTEN, TG, BRAF, TSHR
34subacute thyroiditis30.0TG, TSHR
35nontoxic goiter30.0TG, TSHR
36squamous cell carcinoma of the head and neck30.0EGF, CDKN1A, RASSF1, PIK3CA
37cowden disease30.0RET, PTEN, PIK3CA
38glioblastoma multiforme29.9PIK3CA, PTEN, CDKN1A, EGF
39brain cancer29.9PIK3CA, PTEN, CDKN1A, EGF
40colon cancer29.9PIK3CA, PTTG1, BRAF, CDKN1A, EGF, HRAS
41astrocytoma29.9PIK3CA, PTTG1, PTEN, RASSF1, CDKN1A, EGF
42hepatocellular carcinoma29.8PIK3CA, PTTG1, PTEN, NKX2-1, RASSF1, KISS1R
43follicular adenoma29.7PPARG, PTEN, TG, BRAF, PAX8, TSHR
44cervicitis10.6
45endotheliitis10.5
46familial papillary thyroid carcinoma10.4
47thyroid hurthle cell carcinoma10.4
48hyperthyroidism10.4
49mediastinitis10.3
50nonmedullary thyroid carcinoma, with or without cell oxyphilia10.3

Graphical network of the top 20 diseases related to Thyroid Cancer:



Diseases related to thyroid cancer

Symptoms for Thyroid Cancer

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Drugs & Therapeutics for Thyroid Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Thyroid Cancer

Drug clinical trials:

Search ClinicalTrials for Thyroid Cancer

Search NIH Clinical Center for Thyroid Cancer

Search CenterWatch for Thyroid Cancer

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Thyroid Cancer

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Anatomical Context for Thyroid Cancer

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Thyroid Cancer:

34
Thyroid, Testes, Lymph node, Endothelial, Bone, Lung, Breast, Pituitary, T cells, Salivary gland, Liver, Skin, Myeloid, Ovary, Brain, Nk cells, Colon, Thymus, Prostate, Testis, Cervix

FMA organs/tissues related to Thyroid Cancer:

15
The thryoid gl

Animal Models for Thyroid Cancer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Thyroid Cancer:

38 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1CDKN1A, RET, BRAF, PTEN, PIK3CA, PPARG
2MP:00053759.1PPARG, PIK3CA, PTTG1, PTEN, BRAF, CDKN1A
3MP:00053889.0PTEN, BRAF, RET, CALCA, NKX2-1, CDKN1A
4MP:00053708.9PPARG, PTEN, BRAF, NRAS, KISS1R, CDKN1A
5MP:00053918.9PPARG, PIK3CA, PTEN, BRAF, NRAS, CDKN1A
6MP:00053818.9PTEN, BRAF, RET, NKX2-1, NRAS, KISS1R
7MP:00053778.9PPARG, PAX8, TSHR, CALCA, CDKN1A
8MP:00053908.7PPARG, PTEN, BRAF, PAX8, CALCA, NKX2-1
9MP:00030128.7PPARG, PIK3CA, PTTG1, PAX8, RET, NKX2-1
10MP:00107718.5PPARG, PIK3CA, PTEN, BRAF, CALCA, NRAS
11MP:00020068.4PPARG, PIK3CA, PTEN, BRAF, RET, CALCA
12MP:00028738.4PPARG, PTEN, BRAF, RET, CALCA, NRAS
13MP:00053978.3PPARG, PTTG1, PTEN, TG, BRAF, TSHR
14MP:00053808.2PTEN, PTTG1, PIK3CA, PPARG, BRAF, PAX8
15MP:00053678.2PPARG, PTTG1, PTEN, BRAF, PAX8, RET
16MP:00053858.1PAX8, BRAF, PTEN, PIK3CA, PPARG, RET
17MP:00053848.1PTEN, PTTG1, PIK3CA, PPARG, BRAF, PAX8
18MP:00053868.0BRAF, PTEN, PTTG1, PIK3CA, PPARG, TSHR
19MP:00053877.9BRAF, PTEN, PTTG1, PIK3CA, PPARG, TSHR
20MP:00053897.9PPARG, PIK3CA, PTTG1, PTEN, BRAF, PAX8
21MP:00053797.6HRAS, PPARG, PIK3CA, PTTG1, PTEN, TG
22MP:00036317.5BRAF, TG, PTEN, PTTG1, PIK3CA, PPARG
23MP:00053787.4BRAF, TG, PTEN, PTTG1, PIK3CA, PPARG
24MP:00107687.2PAX8, BRAF, PTEN, PTTG1, PIK3CA, PPARG
25MP:00053767.1PAX8, BRAF, TG, PTEN, PTTG1, PIK3CA

Publications for Thyroid Cancer

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53PubMed
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Articles related to Thyroid Cancer:

(show top 50)    (show all 1597)
idTitleAuthorsYear
1
Commentary on: Implications of thyroglobulin antibody positivity in patients with differentiated thyroid cancer: a clinical position statement. (23987661)
2013
2
Evolving approaches to patients with advanced differentiated thyroid cancer. (23575762)
2013
3
Synoptic pathology reporting for thyroid cancer: a review and institutional experience. (24053206)
2013
4
Vandetanib: a novel targeted therapy for the treatment of metastatic or locally advanced medullary thyroid cancer. (23640345)
2013
5
High-Risk Patients with Differentiated Thyroid Cancer T4 Primary Tumors Achieve Remnant Ablation Equally Well Using rhTSH or Thyroid Hormone Withdrawal. (24040896)
2013
6
Differentiated thyroid cancer: indications and extent of central neck dissection--our experience. (24282633)
2013
7
Severe Hyponatremia Following Radioactive Iodine Therapy in Patients with Differentiated Thyroid Cancer. (24093878)
2013
8
MK-2206 causes growth suppression and reduces neuroendocrine tumor marker production in medullary thyroid cancer through Akt inhibition. (23900743)
2013
9
Clinical behavior and genetics of nonsyndromic, familial nonmedullary thyroid cancer. (23652675)
2013
10
Marginal treatment benefit in anaplastic thyroid cancer. (23839797)
2013
11
Notch pathway is activated by MAPK signaling and influences papillary thyroid cancer proliferation. (23544172)
2013
12
Accidental discovery of lung metastases from differentiated thyroid cancer by 99mTc sodium pertechnetate scan in a patient with secondary hyperparathyroidism. (22889782)
2012
13
Incidental detection of hyperfunctioning thyroid cancer metastases in patients presenting with thyrotoxicosis. (22837931)
2012
14
BRAF(V600E) mutation in Turkish patients with papillary thyroid cancer: strong correlation with indicators of tumor aggressiveness. (22426956)
2012
15
Extended RET gene analysis in patients with apparently sporadic medullary thyroid cancer: clinical benefits and cost. (22648435)
2012
16
Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer. (21826673)
2012
17
Rearranged anaplastic lymphoma kinase (ALK) gene in adult-onset papillary thyroid cancer amongst atomic bomb survivors. (23050789)
2012
18
Expression of estrogen and androgen receptors in differentiated thyroid cancer: an additional criterion to assess the patient's risk. (22531679)
2012
19
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. (21606412)
2011
20
Current role of metaiodobenzylguanidine in the diagnosis of pheochromocytoma and medullary thyroid cancer. (21803186)
2011
21
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. (22105174)
2011
22
Germline RET sequence variation I852M and occult medullary thyroid cancer: harmless polymorphism or causative mutation? (21711375)
2011
23
Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. (20371662)
2010
24
Thyroid cancers amongst goiter population in a Nigerian tertiary hospital: surgical and radiographic perspective. (21526634)
2010
25
The mitogen-activated protein kinase (MAPK) signaling pathway in papillary thyroid cancer. From the molecular bases to clinical practice]. (19627734)
2009
26
Follicular thyroid cancer cell growth inhibition by proteosome inhibitor MG132. (19552924)
2009
27
Medullary thyroid cancer: molecular biology and novel molecular therapies. (19468197)
2009
28
Ablative free thyroxine to thyroglobulin ratio as a predictor of differentiated thyroid cancer recurrence. (19769825)
2009
29
Genetic aspects of familial thyroid cancer. (19465682)
2009
30
The follow-up of patients with differentiated thyroid cancer and undetectable thyroglobulin (Tg) and Tg antibodies during ablation. (18166820)
2008
31
Fluorodeoxyglucose PET/CT in patients with differentiated thyroid cancer and elevated thyroglobulin after total thyroidectomy and (131)I ablation. (17538522)
2008
32
Dysregulated RET signaling in thyroid cancer. (18502331)
2008
33
Predicting the development of Cushing's syndrome in medullary thyroid cancer: utility of proopiomelanocortin messenger ribonucleic acid in situ hybridization. (17696832)
2007
34
Normocalcemic, subclinical, asymptomatic primary hyperparathyroidism in patients with goiter or papillary thyroid cancer--preliminary report. Normocalcemic primary hyperparathyroidism and thyroid pathology. (17966885)
2007
35
Differential effects of cetuximab and AEE 788 on epidermal growth factor receptor (EGF-R) and vascular endothelial growth factor receptor (VEGF-R) in thyroid cancer cell lines. (17873319)
2007
36
Positive predictive value of detectable stimulated tg during the first year after therapy of thyroid cancer and the value of comparison with Tg-ablation and Tg measured after 24 months. (17123341)
2006
37
Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer. (16263812)
2006
38
Risk of thyroid cancer after childhood exposure to ionizing radiation for tinea capitis. (17018661)
2006
39
Additive antitumor effects of gefitinib and imatinib on anaplastic thyroid cancer cells. (16435154)
2006
40
Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. (15767343)
2005
41
Increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer. (16189643)
2005
42
Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. (15743786)
2005
43
Papillary thyroid cancer with chest metastases only detected using radioactive iodine. (15605906)
2004
44
Treatment of iodine-negative thyroglobulin-positive thyroid cancer: differences in outcome in patients with macrometastases and patients with micrometastases. (15232654)
2004
45
Procedure guidelines for radioiodine therapy of differentiated thyroid cancer (version 2)]. (15316577)
2004
46
Pulmonary epithelioid hemangioendothelioma coexistent with pulmonary metastasis of thyroid cancer. (11518122)
2001
47
Treating the patient with differentiated thyroid cancer with thyroglobulin-positive iodine-131 diagnostic scan-negative metastases: including comments on the role of serum thyroglobulin monitoring in tumor surveillance. (10787191)
2000
48
18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography localizes residual thyroid cancer in patients with negative diagnostic (131)I whole body scans and elevated serum thyroglobulin levels. (10404792)
1999
49
A case of follicular thyroid cancer with tracheal stenosis responded to external radiation therapy. (10378657)
1999
50
Infrequent CDKN2 mutation in human differentiated thyroid cancers. (8561866)
1996

Variations for Thyroid Cancer

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Expression for genes affiliated with Thyroid Cancer

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroid Cancer

Search GEO for disease gene expression data for Thyroid Cancer.

Pathways for genes affiliated with Thyroid Cancer

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters, 62Tocris Bioscience, 54QIAGEN, 31KEGG, 13EMD Millipore, 52PharmGKB, 55R&D Systems
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Pathways related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
EGFR-dependent Endothelin signaling events39
9.9HRAS, EGF, NRAS
2
Show member pathways
9.9NRAS, EGF, HRAS
39.9RET, HRAS, PIK3CA
49.9HRAS, EGF, PIK3CA
5
Show member pathways
9.9BRAF, NRAS, HRAS
69.8PIK3CA, BRAF, HRAS
7
Show member pathways
9.7HRAS, EGF, NRAS, PIK3CA
8
Show member pathways
9.7PIK3CA, BRAF, NRAS, HRAS
99.7PIK3CA, BRAF, NRAS, HRAS
10
Show member pathways
9.7BRAF, NRAS, EGF, HRAS
11
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.7HRAS, CDKN1A, PTEN, PIK3CA
12
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.6PPARG, BRAF, NRAS, HRAS
139.6PTEN, BRAF, CDKN1A, HRAS
149.5PIK3CA, BRAF, RASSF1, EGF
159.5PIK3CA, BRAF, PAX8, HRAS
16
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.5PIK3CA, PTEN, NRAS, CDKN1A, HRAS
17
Show member pathways
9.5PIK3CA, BRAF, RET, NRAS, HRAS
18
Show member pathways
9.5HRAS, EGF, NRAS, BRAF, PIK3CA
19
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
9.5PIK3CA, PTEN, BRAF, NRAS, HRAS
20
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
9.5HRAS, EGF, CDKN1A, PTEN, PIK3CA
21
Show member pathways
9.4PTEN, BRAF, NRAS, EGF, HRAS
229.4PIK3CA, BRAF, NRAS, CDKN1A, HRAS
23
Show member pathways
9.4HRAS, CDKN1A, NRAS, BRAF, PIK3CA
24
Show member pathways
9.4PPARG, PIK3CA, BRAF, NRAS, HRAS
25
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.4PIK3CA, PTEN, BRAF, CDKN1A, HRAS
269.3HRAS, CDKN1A, NRAS, PTTG1, PIK3CA
27
Show member pathways
9.3PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
28
Show member pathways
9.3PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
29
Show member pathways
9.3PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
309.3PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
31
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
9.3PIK3CA, BRAF, RET, NRAS, EGF, HRAS
32
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
9.2PIK3CA, PTEN, BRAF, NRAS, EGF, HRAS
33
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.2PIK3CA, PTEN, BRAF, NRAS, EGF, HRAS
349.2PIK3CA, PTTG1, PTEN, CDKN1A, EGF
359.2PIK3CA, PTEN, NRAS, RASSF1, CDKN1A, HRAS
36
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.2PIK3CA, BRAF, NRAS, CDKN1A, EGF, HRAS
379.2PIK3CA, BRAF, NRAS, CDKN1A, EGF, HRAS
38
Show member pathways
9.2PIK3CA, BRAF, NRAS, CDKN1A, EGF, HRAS
399.2PTEN, BRAF, NRAS, CDKN1A, EGF, HRAS
40
Show member pathways
9.2PIK3CA, BRAF, NRAS, RASSF1, EGF, HRAS
41
Show member pathways
9.2HRAS, EGF, NRAS, BRAF, PTEN, PPARG
429.1PPARG, BRAF, PAX8, RET, NRAS, HRAS
43
Show member pathways
Signal transduction PTEN pathway61
9.0PIK3CA, PTEN, BRAF, NRAS, CDKN1A, EGF
44
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
9.0PIK3CA, PTEN, BRAF, NRAS, CDKN1A, EGF
45
Show member pathways
9.0PIK3CA, PTEN, BRAF, NRAS, CDKN1A, EGF
46
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
9.0PPARG, PIK3CA, PTEN, BRAF, NRAS, EGF
47
Show member pathways
Signaling Pathways in Glioblastoma39
8.8PIK3CA, PTEN, BRAF, NRAS, RASSF1, CDKN1A
488.7PIK3CA, PTEN, BRAF, CALCA, NRAS, CDKN1A
49
Show member pathways
8.2PIK3CA, PTEN, BRAF, TSHR, CALCA, NRAS
508.0HRAS, PPARG, PIK3CA, PTEN, BRAF, PAX8

Compounds for genes affiliated with Thyroid Cancer

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Thyroid Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1panitumumab46 52 1212.1EGF, BRAF, PTEN
2phenylacetate4610.1PPARG, CDKN1A, HRAS
3mithramycin469.9CDKN1A, CALCA, PPARG
4iodine46 2510.8TSHR, BRAF, TG
5gefitinib46 52 1211.8PIK3CA, PTEN, CDKN1A, EGF
6crcs469.8PIK3CA, PTEN, BRAF, RASSF1, HRAS
7gemcitabine46 52 1211.8HRAS, EGF, CDKN1A, PTEN
8rosiglitazone30 46 52 25 1213.8PPARG, PIK3CA, PTEN, TSHR, CDKN1A
9imatinib46 52 1211.7PIK3CA, PTEN, BRAF, RET, CDKN1A
10phosphotyrosine469.7PIK3CA, PTEN, RET, EGF, HRAS
11lovastatin46 52 62 30 1213.7HRAS, EGF, CDKN1A, PTEN
12calcitriol46 62 25 1212.6PTEN, TG, CALCA, CDKN1A, EGF
13sodium iodide469.6TG, NKX2-1, RET, TSHR, PAX8, BRAF
14thyroxine46 2510.6PPARG, TG, PAX8, TSHR, CALCA
15iodide46 2510.6PIK3CA, TG, BRAF, PAX8, TSHR, NKX2-1
1612-o-tetradecanoylphorbol 13-acetate469.6BRAF, TSHR, RET, CDKN1A, EGF, HRAS
17phosphoinositide469.5PIK3CA, PTEN, BRAF, TSHR, EGF, HRAS
18paclitaxel46 52 1211.5PIK3CA, PTEN, BRAF, CDKN1A, EGF, HRAS
19methionine469.5PTEN, TSHR, RET, RASSF1, HRAS
20aspartate469.5HRAS, RET, TSHR, BRAF, TG, PTEN
21ribonucleic acid469.4PTTG1, TG, PAX8, TSHR, RET, NKX2-1
22pge2469.4PPARG, PTEN, CALCA, CDKN1A, EGF, HRAS
23adenylate469.4PIK3CA, TG, TSHR, CALCA, EGF, HRAS
24pd 98,059469.4PIK3CA, PTEN, BRAF, RET, CDKN1A, EGF
25wortmannin469.4PIK3CA, PTEN, BRAF, RET, CDKN1A, EGF
26sodium46 2510.4PIK3CA, TG, BRAF, PAX8, TSHR, NKX2-1
27forskolin46 52 1211.4BRAF, PAX8, TSHR, CALCA, NKX2-1, EGF
28rapamycin469.3PPARG, PIK3CA, PTEN, BRAF, CDKN1A, EGF
29arginine469.3PIK3CA, PTEN, TG, BRAF, TSHR, RET
30thymidine46 2510.3PIK3CA, PTTG1, TG, TSHR, CDKN1A, EGF
31paraffin469.3PTEN, TG, BRAF, TSHR, RET, NKX2-1
32testosterone46 62 25 1212.3PPARG, PIK3CA, PTEN, TG, RET, CALCA
33genistein46 30 62 3 25 1214.3PPARG, PIK3CA, PTEN, TG, RET, CDKN1A
34progesterone46 30 62 25 1213.2PIK3CA, PTEN, BRAF, TSHR, NKX2-1, CDKN1A
35cyclic amp46 2510.2PTEN, BRAF, TSHR, RET, CALCA, NKX2-1
36ly294002469.2PPARG, PIK3CA, PTEN, BRAF, RET, CDKN1A
37cisplatin46 52 62 1212.2PIK3CA, PTEN, TG, BRAF, RASSF1, CDKN1A
38phosphatidylinositol469.1PIK3CA, PTTG1, PTEN, BRAF, TSHR, RET
39alanine469.0PPARG, PTEN, TG, BRAF, TSHR, RET
40h2o2469.0PIK3CA, PTEN, TG, CDKN1A, EGF, HRAS
41cysteine468.9PTTG1, PTEN, TG, TSHR, RET, EGF
42oligonucleotide468.7TSHR, PAX8, BRAF, PTEN, RET, NKX2-1
43threonine468.5PIK3CA, PTEN, BRAF, PAX8, TSHR, RET
44agar468.5RASSF1, NRAS, RET, BRAF, TG, PTEN
45tyrosine468.4TSHR, BRAF, TG, PTEN, PIK3CA, RET
46retinoic acid46 259.4BRAF, TG, PTEN, PIK3CA, PPARG, TSHR
47calcium46 52 25 1211.4PIK3CA, PTTG1, PTEN, BRAF, TSHR, RET
48serine468.3PAX8, BRAF, TG, PTEN, PIK3CA, TSHR
49vegf468.2PPARG, PIK3CA, PTTG1, PTEN, TG, BRAF
50estrogen468.0HRAS, EGF, CDKN1A, RASSF1, NKX2-1, CALCA

GO Terms for genes affiliated with Thyroid Cancer

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17Gene Ontology
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Cellular components related to Thyroid Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.5PTEN, BRAF, TSHR, NRAS, RASSF1, KISS1R
2cytosolGO:0058298.1HRAS, NNMT, PPARG, PIK3CA, PTTG1, PTEN

Biological processes related to Thyroid Cancer according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Rac protein signal transductionGO:03502210.3NRAS, HRAS
2regulation of synaptic transmission, GABAergicGO:03222810.3HRAS, NRAS
3thyroid-stimulating hormone signaling pathwayGO:03819410.3PAX8, TSHR
4thyroid gland developmentGO:03087810.1NKX2-1, PAX8, TG
5positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.1PTEN, EGF
6MAPK cascadeGO:00016510.1RET, NRAS, HRAS
7endothelial cell migrationGO:04354210.1PIK3CA, PTEN, CALCA
8striated muscle cell differentiationGO:05114610.0HRAS, NRAS
9response to arsenic-containing substanceGO:04668510.0PTEN, CDKN1A
10Ras protein signal transductionGO:00726510.0NRAS, RASSF1, CDKN1A, HRAS
11negative regulation of neuron apoptotic processGO:04352410.0HRAS, NRAS, BRAF, PIK3CA
12leukocyte migrationGO:0509009.9HRAS, NRAS, PIK3CA
13phosphatidylinositol-mediated signalingGO:0480159.9EGF, CDKN1A, PTEN, PIK3CA
14organ regenerationGO:0311009.8NNMT, PPARG, CDKN1A
15positive regulation of cell proliferationGO:0082849.8HRAS, EGF, NRAS, TSHR, PTEN
16activation of MAPKK activityGO:0001869.7BRAF, NRAS, KISS1R, EGF, HRAS
17negative regulation of cell proliferationGO:0082859.7PTEN, RNF139, KISS1R, CDKN1A, HRAS
18Fc-epsilon receptor signaling pathwayGO:0380959.6PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
19epidermal growth factor receptor signaling pathwayGO:0071739.6PIK3CA, PTEN, NRAS, CDKN1A, EGF, HRAS
20positive regulation of transcription, DNA-templatedGO:0458939.5EGF, NKX2-1, RET, PAX8, PPARG
21response to drugGO:0424939.5NNMT, PPARG, PTEN, RET, CDKN1A
22fibroblast growth factor receptor signaling pathwayGO:0085439.4HRAS, PIK3CA, PTEN, BRAF, NRAS, CDKN1A
23innate immune responseGO:0450879.4PPARG, PIK3CA, PTEN, NRAS, CDKN1A, EGF
24neurotrophin TRK receptor signaling pathwayGO:0480119.4PIK3CA, PTEN, BRAF, NRAS, CDKN1A, EGF
25protein phosphorylationGO:0064689.2BRAF, RET, CALCA, CDKN1A

Molecular functions related to Thyroid Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid-stimulating hormone receptor activityGO:00499610.0TSHR, PAX8
2protein bindingGO:0055156.4HRAS, PPARG, PIK3CA, PTTG1, PTEN, BRAF

Products for genes affiliated with Thyroid Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thyroid Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet