Thyroid Carcinoma malady

Wikipedia: Thyroid neoplasm is a neoplasm or tumor of the thyroid. It can be a benign tumor such as thyroid...⁴⁴ more...

MalaCards: Thyroid Carcinoma, also known as head and neck cancer, thyroid, is related to thyroiditis and carcinoma. An important gene associated with Thyroid Carcinoma is RET (ret proto-oncogene), and among its related pathways are Pathways in cancer and MAPK Signaling. The compounds serine and vegf have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Aliases & Descriptions:

thyroid carcinoma 6 7 32 43 head and neck cancer, thyroid 6

cancer of head and neck 43

Diseases related to thyroid carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 879)

id	Related Disease	Score	Top Affiliating Genes
1	thyroiditis	103.0	PIK3CA, PIK3C2A, PIK3CG, LRP1, NCAM1, NCOA4
2	carcinoma	102.3	PIK3CA, PIK3C2A, PIK3CG, LRP1, NCAM1, NCOA4
3	leukemia	64.6	PIK3CA, PIK3C2A, PIK3CG, LRP1, NCAM1, RECK
4	adenocarcinoma	62.9	PIK3CA, PIK3C2A, PIK3CG, LRP1, NCAM1, RECK
5	neuronitis	62.4	PIK3CA, PIK3C2A, PIK3CG, LRP1, NCAM1, PDE1C
6	melanoma	62.2	PIK3CA, PIK3C2A, PIK3CG, LRP1, NCAM1, PDE1C
7	adenoma	62.0	PIK3CA, NCAM1, RECK, RET, RETN, KIT
8	hepatitis	61.1	PIK3CA, PIK3C2A, PIK3CG, LRP1, NCAM1, RETN
9	cervicitis	59.9	PIK3CA, PIK3CG, RECK, RET, KIT, SFN
10	papillary thyroid carcinoma	53.7	NCOA4, RET, SERPINB5, NAA15, BRAF, VEGFC
11	colon cancer	53.4	PIK3CA, PIK3CG, NCAM1, RECK, RETN, CNR2
12	neuroblastoma	52.0	ZNF121, PIK3CA, PIK3CG, LRP1, NCAM1, PDE1C
13	lung carcinoma	48.4	PIK3CA, PIK3CG, NCAM1, RECK, PCNA, BUB1
14	colon carcinoma	46.1	PIK3CA, PIK3CG, NCAM1, KIT, SELE, SELP
15	pheochromocytoma	45.1	PIK3C2A, NCAM1, RET, KIT, PCSK2, VIP
16	polyposis	44.4	PIK3CG, RET, PCNA, BUB1, BUB1B, RB1
17	retinoblastoma	44.1	PIK3CA, PIK3CG, NCAM1, RECK, KIT, PCNA
18	pituitary adenoma	42.9	NCAM1, RECK, RET, KIT, PCSK2, PCNA
19	multiple endocrine neoplasia	42.3	RET, VIP, VHL, SDHB, SDHC, SDHD
20	lung adenocarcinoma	42.1	PIK3CA, PIK3CG, RB1, SERPINA1, BRAF, VEGFA
21	goiter	41.5	RET, SELE, NAALADL1, BRAF, VHL, VEGFA
22	prostatitis	40.1	PIK3CA, PIK3C2A, PIK3CG, LRP1, NCAM1, NCOA4
23	carcinoid tumors	39.8	NCAM1, RET, PCSK2, PCNA, VIP, RAF1
24	familial adenomatous polyposis	39.7	PCNA, RB1, VIM, BRAF, VHL, MYC
25	pancreatitis	39.0	PIK3CA, PIK3C2A, PIK3CG, LRP1, NCAM1, RECK
26	familial medullary thyroid carcinoma	39.0	RET, SDHB, SDHC, SDHD, FOS, MAPK3
27	thyroid cancer, anaplastic	38.9	PIK3CA, RET, BRAF, BMP7, RAN, PAX8
28	graves' disease	38.6	RETN, SELE, VDR, LMOD1, MYC, BMP6
29	hyperparathyroidism	37.8	RET, PCNA, SELE, VIP, VEGFA, VDR
30	paraganglioma	37.7	NCAM1, RET, KIT, PCNA, VIM, VIP
31	noma	37.3	PIK3CA, PIK3CG, RET, KIT, PCNA, RB1
32	neuroendocrine tumor	37.1	NCAM1, RET, VIP, MYCN, RAF1, RASSF1
33	multiple endocrine neoplasia type 2a	37.1	RET, VHL, SDHB, SDHC, SDHD, MEN1
34	herpes simplex	37.1	PIK3CA, PIK3CG, RECK, PCNA, VIM, NAA15
35	thyroid cancer	36.2	RET, SERPINB5, BRAF, PAX8, LGALS1, LGALS3
36	thyroid adenoma	35.9	PIK3CA, RET, BRAF, RAF1, RASSF1, BGLAP
37	duodenitis	35.9	PIK3CG, KIT, PCNA, VIP, BRAF, VDR
38	thyroid medullary carcinoma	35.8	NCAM1, RET, BRAF, VEGFC, PAX8, LGALS3
39	hyperthyroidism	35.7	PIK3C2A, RETN, PCSK2, SELE, SELP, LPO
40	colorectal cancer	35.6	PIK3CA, PIK3CG, NCAM1, RECK, RET, RETN
41	follicular adenoma	35.2	RET, RAP1A, RAP1B, BIRC5, LGALS3, S100A4
42	hirschsprung's disease	35.0	NCAM1, RET, VIP, ARTN, CTSD, NTRK1
43	multinodular goiter	34.8	NAALADL1, VHL, VEGFA, LEP, IL1A, IL1B
44	folliculitis	34.8	KIAA1671, NACA, ZFP36L2, BCL6, MPP1, ARPP19
45	thyroid cancer, follicular	34.6	PIK3CA, RASSF1, KDR, CDKN1A, FOS, CALCA
46	hepatocellular carcinoma	34.5	PIK3CA, PIK3CG, NCAM1, RECK, RET, CNR2
47	gastric cancer	34.1	PIK3CA, PIK3CG, RECK, RETN, KIT, PCNA
48	cushing's syndrome	33.9	RET, RETN, BGLAP, LEP, CHGA, INS
49	anaplastic carcinoma	33.7	RET, VIM, BRAF, PAX8, LGALS1, LGALS3
50	nodular goiter	33.1	RET, BRAF, VEGFC, LGALS3, CD86, CD80

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to thyroid carcinoma:

²²

MGI Mouse Phenotypes related to thyroid carcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	30.3	PIK3CA, PIK3C2A, PIK3CG, LRP1, RET, RETN
2	growth/size phenotype	MP:0005378	29.1	PIK3CA, PIK3C2A, PIK3CG, LRP1, RECK, RET
3	cellular phenotype	MP:0005384	28.6	PIK3CA, PIK3CG, NCAM1, RET, KIT, KIAA0101
4	mortality/aging	MP:0010768	26.9	PIK3CA, PIK3C2A, LRP1, NCAM1, RECK, RET
5	cardiovascular system phenotype	MP:0005385	25.5	PIK3CA, PIK3CG, LRP1, RECK, RET, KIT
6	nervous system phenotype	MP:0003631	24.1	LRP1, RECK, KIT, RB1, SELP, BRAF
7	immune system phenotype	MP:0005387	21.7	LRP1, CNR2, KIT, KIAA0101, SFN, BUB1
8	reproductive system phenotype	MP:0005389	21.5	PIK3CA, RET, SFN, PCSK2, BUB1, BUB1B
9	behavior/neurological phenotype	MP:0005386	21.2	PIK3CA, LRP1, NCAM1, KIT, PCSK2, RB1
10	digestive/alimentary phenotype	MP:0005381	21.1	RET, KIT, SFN, RB1, BRAF, VHL
11	vision/eye phenotype	MP:0005391	20.9	PIK3CA, NCAM1, KIT, SFN, BUB1B, RB1
12	tumorigenesis	MP:0002006	20.8	PIK3CA, RET, KIT, SFN, BUB1, BUB1B
13	muscle phenotype	MP:0005369	20.2	PIK3CA, PIK3CG, LRP1, RET, KIT, BUB1B
14	normal phenotype	MP:0002873	19.8	LRP1, RET, BUB1, SELE, VIP, BRAF
15	integument phenotype	MP:0010771	19.0	PIK3CG, RECK, CNR2, KIT, SFN, PCSK2
16	skeleton phenotype	MP:0005390	18.6	PIK3CG, LRP1, RECK, KIT, SFN, BUB1B
17	hematopoietic system phenotype	MP:0005397	18.4	KIT, KIAA0101, SFN, PCNA, BUB1, BUB1B
18	renal/urinary system phenotype	MP:0005367	17.7	RET, KIT, SELP, BRAF, VHL, MYCN
19	embryogenesis phenotype	MP:0005380	17.2	PIK3CA, RECK, RET, KIT, SFN, BUB1B
20	limbs/digits/tail phenotype	MP:0005371	15.5	RECK, RET, KIT, SFN, RB1, VHL
21	endocrine/exocrine gland phenotype	MP:0005379	15.2	RET, SFN, PCSK2, BUB1, MYT1, RARG
22	no phenotypic analysis	MP:0003012	15.2	RET, PCNA, BUB1, RB1, VEGFA, MYC
23	hearing/vestibular/ear phenotype	MP:0005377	14.5	KIT, SFN, RB1, VDR, MYC, BMP7
24	adipose tissue phenotype	MP:0005375	14.0	PIK3CA, PIK3C2A, LRP1, RETN, BUB1B, RB1
25	craniofacial phenotype	MP:0005382	14.0	KIT, LMNB1, MYCN, BMP1, RARG, RASA1
26	liver/biliary system phenotype	MP:0005370	13.8	RECK, RETN, KIT, SFN, BUB1, VHL
27	pigmentation phenotype	MP:0001186	13.8	KIT, RB1, BRAF, MYC, BMP7, BCL2
28	respiratory system phenotype	MP:0005388	12.6	RET, SELP, MYCN, LIF, BDNF, BCL6
29	other phenotype	MP:0005395	12.0	RECK, BUB1, RARG, RARA, RARB, CLU

Articles related to thyroid carcinoma:

(show top 50)    (show all 1503)

id	Title	Authors	Year	Affiliating Genes
1	Use of sodium iodide symporter expression in differen tiated thyroid carcinomas. (21521301)	Morari E.C.... Ward L.S.	2011	SLC5A5
2	Medullary thyroid carcinoma cell lines contain a self -renewing CD133+ population that is dependent on ret proto-oncogene activity. (19897677)	Zhu W.... Cote G.J.	2010	RET
3	Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma. (20008098)	Uddin S.... Al-Kuraya K.S.	2010	AKT1, PIK3CA, LEP
4	Coexistent familial nonmultiple endocrine neoplasia m edullary thyroid carcinoma and papillary thyroid carcinoma associated with RET polymorphism. (20463576)	Gul K.... Cakir B.	2010	RET
5	Successful treatment of anaplastic thyroid carcinoma with a combination of oral valproic acid, chemotherapy, radiation and surgery. (19088401)	Noguchi H.... Noguchi S.	2009	HDAC9
6	Influence of age and primary tumor size on the risk for residual/recurrent well-differentiated thyroid carcinoma. (19260133)	Orlov S.... Walfish P.G.	2009	TG
7	Detection and molecular characterization of a novel BRAF activated domain mutation in follicular variant of papillary thyroid carcinoma. (19200582)	Santarpia L.... El-Naggar A.K.	2009	BRAF
8	Occurrence of medullary thyroid carcinoma, bronchial carcinoid tumor, and papillary thyroid carcinoma in a family bearing the RET G691S polymorphism. (19411807)	Rotondi M.... Chiovato L.	2009	RET
9	Serum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma. (18376194)	Yu X.M.... Luk J.M.	2008	VEGFC
10	Limited value of repeat recombinant human thyrotropin (rhTSH)-stimulated thyroglobulin testing in differentiated thyroid carcinoma patients with previous negative rhTSH-stimulated thyroglobulin and undetectable basal serum thyroglobulin levels. (17971424)	Castagna M.G.... Pacini F.	2008	TG
11	Familial non-medullary thyroid carcinoma: an update. (18931957)	NosAc V.	2008	PTEN
12	Mutation Analysis of RAP1 Gene in Papillary Thyroid Carcinomas. (18948674)	Matsuse M.... Yamashita S.	2008	BRAF, RAP1A, RAP1B
13	Rosiglitazone effect on radioiodine uptake in thyroid carcinoma patients with high thyroglobulin but negative total body scan: a correlation with the expression of peroxisome proliferator-activated receptor-gamma. (18630997)	Tepmongkol S.... Ruangvejvorachai P.	2008	PPARG, TG
14	Low-level genomic instability is a feature of papillary thyroid carcinoma: an array comparative genomic hybridization study of laser capture microdissected papillary thyroid carcinoma tumors and clonal cell lines. (17227125)	Finn S.... Sheils O.	2007	RET, BRAF, PDGFB
15	Y791F RET mutation and early onset of medullary thyroid carcinoma in a Brazilian kindred: evaluation of phenotype-modifying effect of germline variants. (17610518)	Tamanaha R.... Cerutti J.M.	2007	RET
16	BRAF in papillary thyroid carcinoma of ovary (struma ovarii). (17721188)	Schmidt J.... Nose V.	2007	BRAF
17	HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma. (17639057)	Ciampi R.... Nikiforov Y.E.	2007	RET, HOOK3
18	Nitric oxide in papillary thyroid carcinoma: induction of vascular endothelial growth factor D and correlation with lymph node metastasis. (16418215)	Nakamura Y.... Kakudo K.	2006	FIGF
19	Maspin protein expression: a special feature of papillary thyroid carcinoma. (17671538)	Shams T.M.... Shams M.E.	2006	SERPINB5
20	Efficacy of radioiodine therapy in the treatment of elevated serum thyroglobulin in patients with differentiated thyroid carcinoma and negative whole-body iodine scan. (16794517)	Saghari M.... Beiki D.	2006	TG
21	Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a novel gene responsible for anaplastic thyroid carcinoma. (15789362)	Mizutani K.... Emi M.	2005	KIAA0101
22	Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness. (15998773)	Guarino V.... Santoro M.	2005	SPP1
23	Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. (15562011)	Sorrentino R.... Portella G.	2005	AURKB
24	Diagnostic modalities in patients affected by differentiated thyroid carcinoma with high thyroglobulin levels and total body Iodium-131 negative: PET/CT use after recTSH (15765025)	Biscontini G.... Rossetti C.	2004	TG
25	Cribriform-morular variant of papillary thyroid carcinoma: ultrastructural study and somatic/germline mutation analysis of the APC gene. (15205109)	Kameyama K.... Ito K.	2004	APC
26	BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas. (15126572)	Puxeddu E.... Santeusanio F.	2004	BRAF
27	Microarray analysis of metastasis-associated gene expression profiling in a murine model of thyroid carcinoma pulmonary metastasis: identification of S100A4 (Mts1) gene overexpression as a poor prognostic marker for thyroid carcinoma. (15579771)	Zou M.... Shi Y.	2004	S100A4, EZR
28	The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma. (15277225)	Melillo R.M.... Santoro M.	2004	RET
29	Erythropoietin and the erythropoietin receptor are expressed by papillary thyroid carcinoma from children and adolescents. Expression of erythropoietin receptor might be a favorable prognostic indicator. (14584755)	Eccles T.G.... Francis G.L.	2003	EPOR, EPO
30	FDG PET and alternative imaging in the management of thyroid carcinoma. (14737730)	Al-Nahhas A.M.	2003	TG
31	Papillary thyroid carcinoma in patients with RET proto-oncogene germline mutation. (12193298)	Brauckhoff M.... Dralle H.	2002	RET
32	Expression of receptor-type tyrosine kinase, Axl, and its ligand, Gas6, in pediatric thyroid carcinomas around chernobyl. (12490074)	Ito M.... Yamashita S.	2002	AXL, GAS6
33	Glandular patterns in a thyroid carcinoma with insular and anaplastic features: a case with possible implications for the classification of thyroid carcinomas. (12478492)	Fadare O.... Sinard J.H.	2002	CALCA
34	From gene to disease; from the RET gene to multiple endocrine neoplasia types 2A and 2B, sporadic and familial medullary thyroid carcinoma, Hirschsprung disease and papillary thyroid carcinoma (11757244)	Hofstra R.M.... Lips C.J.	2001	RET
35	Diagnostic approach, genetic screening and prognostic factors of medullary thyroid carcinoma. (11370543)	Corsello S.M.... Summaria V.	2000	RET, CALCA
36	Dedifferentiation of neoplastic cells in medullary thyroid carcinoma: report of a case. (10552340)	Osaka M.... Suzuki T.	1999	CALCA, CHGA
37	No correlation between RET immunostaining and the codon 918 mutation in sporadic medullary thyroid carcinoma. (10367632)	Bockhorn M.... Broelsch C.E.	1999	RET
38	Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas. (9927064)	Nakamura H.... Okada Y.	1999	MMP2, MMP14, MMP15
39	Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomas. (9827724)	Elisei R.... Fagin J.A.	1998	CDK4, CDKN2A, CDKN2B
40	Genetic testing in medullary thyroid carcinoma syndromes: mutation types and clinical significance. (9146685)	Heshmati H.M.... Thibodeau S.N.	1997	RET
41	Decreased growth rate and tumour formation of human anaplastic thyroid carcinoma cells transfected with a human thyrotropin receptor cDNA in NMRI nude mice treated with propylthiouracil. (8892315)	Gustavsson B.... Heldin N.E.	1996	TSHR
42	Medullary thyroid carcinoma in children with multiple endocrine neoplasia types 2A and 2B. (8632274)	Skinner M.A.... Wells S.A.	1996	RET
43	RET proto-oncogene mutations in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma. (7575334)	Cote G.J.... Gagel R.F.	1995	RET
44	Mutations in the cysteine-rich region of the RET proto-oncogene in patients diagnosed as having sporadic medullary thyroid carcinoma. (8556059)	Kimura T.... Saito S.	1995	RET
45	Pentagastrin stimulation test and early diagnosis of medullary thyroid carcinoma using an immunoradiometric assay of calcitonin: comparison with genetic screening in hereditary medullary thyroid carcinoma. (7904611)	Barbot N.... Bigorgne J.C.	1994	CALCA
46	Polyamines regulate human medullary thyroid carcinoma TT-cell proliferation and secretion of calcitonin and calcitonin gene-related peptide. (7958401)	Sjoholm A.... Nygren P.	1994	ODC1, CALCA, AMD1
47	Immunohistochemical analysis of expression of nm23-H1/nucleoside diphosphate kinase in human thyroid carcinomas: lack of correlation between its expression and lymph node metastasis. (8396479)	Luo W.... Izumi M.	1993	NME1
48	Increase in cytoplasmic Ca2+ and stimulation of calcitonin secretion from human medullary thyroid carcinoma cells by the gastrin-releasing peptide. (1627139)	Abe Y.... Kameya T.	1992	GRP
49	Expression and processing of human preprogastrin in murine medullary thyroid carcinoma cells. (1709790)	Daugherty D.F.... Yamada T.	1991	GAST
50	Strong association between an HLA-DR antigen and thyroid carcinoma. (6814009)	Panza N.... Zappacosta S.	1982	HLA-DRB1

Genes related to thyroid carcinoma according to GeneCards:

(show top 50)    (show all 614)

id	Symbol	Description	Score	GeneCards Section Context
1	RET	ret proto-oncogene	11.1	Publications, Aliases & Descriptions, UniProt Related, Summaries
2	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.1	Publications, Summaries
3	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	11.1	Publications, Summaries
4	NCOA4	nuclear receptor coactivator 4	11.1	Publications, Functions, Summaries
5	PCM1	pericentriolar material 1	11.1	Publications, Summaries
6	PTCPRN	Papillary thyroid carcinoma with papillary renal neoplasia	11.0	Aliases & Descriptions, Publications
7	NMTC1	Nonmedullary thyroid carcinoma 1	11.0	Aliases & Descriptions, Publications
8	TCO	Thyroid carcinoma, nonmedullary, with cell oxyphilia	11.0	Aliases & Descriptions
9	CLDN7	claudin 7	11.0	Summaries
10	NGFR	nerve growth factor receptor	11.0	Summaries
11	NGF	nerve growth factor (beta polypeptide)	11.0	Summaries
12	NTRK2	neurotrophic tyrosine kinase, receptor, type 2	11.0	Publications, Summaries
13	CCDC6	coiled-coil domain containing 6	11.0	Publications, Aliases & Descriptions
14	HCC	thyroid carcinoma, Hurthle cell	11.0	Aliases & Descriptions
15	KIAA0101	KIAA0101	11.0	Publications, Expressions, Aliases & Descriptions
16	PTCSC1	papillary thyroid carcinoma susceptibility candidate 1 (non-protein coding)	11.0	Aliases & Descriptions
17	BDNF	brain-derived neurotrophic factor	11.0	Summaries
18	TG	thyroglobulin	11.0	Publications
19	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
20	PTEN	phosphatase and tensin homolog	11.0	Publications
21	NKX2-1	NK2 homeobox 1	11.0	Publications
22	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
23	TSHR	thyroid stimulating hormone receptor	11.0	Publications
24	PAX8	paired box 8	11.0	Publications
25	SLC26A4	solute carrier family 26, member 4	11.0	Publications
26	TPO	thyroid peroxidase	11.0	Publications
27	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
28	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.0	Publications
29	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications
30	EGF	epidermal growth factor	11.0	Publications
31	PTCSC3	papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding)	11.0	Aliases & Descriptions
32	SLC5A5	solute carrier family 5 (sodium iodide symporter), member 5	11.0	Publications
33	S100A4	S100 calcium binding protein A4	11.0	Publications
34	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
35	VEGFC	vascular endothelial growth factor C	11.0	Publications
36	APC	adenomatous polyposis coli	11.0	Publications
37	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	11.0	Publications
38	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications, Functions
39	DPP4	dipeptidyl-peptidase 4	11.0	Publications
40	GDNF	glial cell derived neurotrophic factor	11.0	Publications
41	MET	met proto-oncogene (hepatocyte growth factor receptor)	11.0	Publications
42	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications
43	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	11.0	Publications
44	PTK2	PTK2 protein tyrosine kinase 2	11.0	Publications
45	THRB	thyroid hormone receptor, beta	11.0	Publications
46	TP53	tumor protein p53	11.0	Publications
47	DIO2	deiodinase, iodothyronine, type II	11.0	Publications
48	KRT19	keratin 19	11.0	Publications
49	DUOX1	dual oxidase 1	11.0	Publications
50	LMOD1	leiomodin 1 (smooth muscle)	11.0	Publications

Pathways related to thyroid carcinoma according to GeneDecks:

(show top 50)    (show all 316)

id	Pathway	Score	Top Affiliating Genes
1	Pathways in cancer20	17.4	PIK3CA, PIK3CG, NCOA4, RET, RB1, VEGFA
2	MAPK Signaling36	16.1	KIT, BRAF, VEGFC, LMTK3, MYC, BMP1
3	Antioxidant Action of Vitamin-C36	15.7	KIT, VEGFC, BMP1, BMP6, BMP7, UTS2
4	cAMP Pathway36	15.2	PDE1C, KIT, BRAF, VEGFC, BMP1, BMP6
5	Focal adhesion20	15.0	PIK3CA, PIK3CG, BRAF, VEGFC, RAP1A, RAF1
6	Cellular Apoptosis Pathway36	14.9	KIT, VEGFC, BMP1, BMP6, BMP7, UTS2
7	Renin-Angiotensin Pathway36	14.8	KIT, VEGFC, BMP1, BMP6, BMP7, RAF1
8	Mitochondrial Apoptosis36	14.7	KIT, VEGFC, BMP1, BMP6, BMP7, UTS2
9	ERK Signaling36	14.6	KIT, BRAF, VEGFC, LMTK3, MYC, BMP1
10	Breast Cancer Regulation by Stathmin136	14.2	LMTK3, BMP1, BMP7, RAF1, UTS2, PAK1
11	Activation of PKA through GPCR36	14.2	PDE1C, KIT, BRAF, VEGFC, LMTK3, BMP1
12	Cytokine-cytokine receptor interaction20	14.0	KIT, VEGFA, VEGFC, BMP7, LIF, KDR
13	Ras Pathway36	14.0	KIT, BRAF, VEGFC, LMTK3, BMP1, BMP7
14	ERK5 Signaling36	13.9	KIT, VEGFC, MYC, BMP1, BMP6, BMP7
15	Rac1 Pathway36	13.9	BMP1, BMP6, BMP7, RAF1, UTS2, PAK1
16	Rap1 Pathway36	13.8	BRAF, VEGFC, BMP1, BMP6, BMP7, RAP1A
17	Neurotrophin signaling pathway20	13.6	PIK3CA, PIK3CG, BRAF, RAP1A, RAF1, RAP1B
18	Activation of cAMP-Dependent PKA36	13.6	PDE1C, VEGFC, LMTK3, BMP1, BMP7, RAP1A
19	NF-KappaB (p50-p65) Pathway36	13.6	VEGFC, BMP1, BMP6, BMP7, UTS2, BDNF
20	MAPK signaling pathway20	13.6	BRAF, MYC, RAP1A, RAF1, RAP1B, RASA1
21	Bladder cancer20	13.3	RB1, BRAF, VEGFA, VEGFC, MYC, RAF1
22	Development_HGF signaling pathway41	13.2	PIK3CA, RAP1A, RAF1, RAPGEF1, JUN, CDH1
23	Cell adhesion_PLAU signaling41	13.1	PIK3CA, RAF1, BCAR1, ITGB1, MET, ILK
24	NF-KappaB Family Pathway36	13.0	VEGFC, BMP1, BMP6, BMP7, UTS2, BDNF
25	Thyroid cancer20	13.0	NCOA4, RET, BRAF, MYC, PAX8, CDH1
26	Renal cell carcinoma20	13.0	VHL, RAP1A, RAF1, RAP1B, RAPGEF1, PAK1
27	Apoptosis20	13.0	PIK3CA, PIK3CG, BCL2, BCL2L1, BAX, XIAP
28	Angiogenesis3	12.9	RECK, SERPINB5, VHL, VEGFC, KDR, ITGA6
29	Apoptosis and Autophagy3	12.9	SERPINB5, LMNB1, MYC, MYCN, BIK, BIRC5
30	Apoptosis and survival BAD phosphorylation10	12.7	PIK3CA, SFN, RAF1, BCL2, BCL2L1, BAX
31	Endothelin-1 Signaling Pathway36	12.7	KIT, BRAF, LMTK3, MYC, BMP1, BMP6
32	p53 Signaling36	12.7	SFN, BCL2, BAX, ATM, CDKN1A, CDK4
33	mTOR Pathway36	12.6	VEGFC, BMP1, BMP6, BMP7, UTS2, BDNF
34	Cell adhesion PLAU signaling10	12.5	PIK3CA, RAF1, BCAR1, ITGB1, MET, HRAS
35	Development HGF signaling pathway10	12.4	PIK3CA, RAP1A, RAF1, RAPGEF1, JUN, FOS
36	Regulation of actin cytoskeleton20	12.4	BRAF, RAF1, PAK1, BCAR1, MSN, ITGA2
37	Tyrosine Kinases / Adaptors3	12.3	RET, KIT, VEGFC, KDR, BCAR1, AXL
38	Signal transduction PTEN pathway10	12.2	PIK3CA, PCNA, RAF1, BCAR1, MTOR, JUN
39	GDNF-Family Ligands and Receptor Interactions36	12.1	RAF1, RASA1, PAK1, JUN, FOS, MAPK8
40	Development_VEGF signaling via VEGFR2 - generic cascades41	12.1	PIK3CA, VEGFA, RAF1, RASA1, PAK1, JUN
41	Germ Cell-Sertoli Cell Junction Dynamics36	12.0	PAK1, BCAR1, JUP, CDH2, ITGB1, ILK
42	Actin-Based Motility by Rho Family GTPases36	11.9	BMP1, BMP7, UTS2, PAK1, BDNF, ITGA6
43	Cell adhesion ECM remodeling10	11.7	MSN, CD44, ITGB1, MMP1, MMP14, MMP15
44	Influenza A20	11.5	PIK3CA, PIK3CG, RAF1, JUN, IL1A, IL1B
45	Cell adhesion_ECM remodeling41	11.5	MSN, CD44, ITGB1, MMP1, MMP14, MMP15
46	Adhesion3	11.3	NCAM1, RAP1A, RAP1B, CEACAM5, JUP, CDH2
47	Development VEGF signaling via VEGFR2 - generic cascades10	11.3	PIK3CA, VEGFA, RAF1, RASA1, KDR, JUN
48	Signal transduction_PTEN pathway41	11.2	PCNA, BCAR1, ITGB1, IGF1R, CASP9, PDPK1
49	Colorectal cancer20	11.1	PIK3CG, BRAF, MSH3, FOS, MAPK8, MAP2K1
50	Regulation of eIF4 and p70S6K36	INF	VEGFC, BMP1, BAX, CD80, ITGA2, ITGA6

Compounds related to thyroid carcinoma according to GeneDecks:

(show top 50)    (show all 423)

id	Compound	Score	Top Affiliating Genes
1	serine32	26.1	PIK3CA, PIK3CG, LRP1, NCAM1, RECK, RET
2	vegf32	22.9	PIK3CA, PIK3C2A, PIK3CG, LRP1, NCAM1, RECK
3	estrogen32	21.3	NCOA4, RETN, PCNA, SERPINB5, SERPINA1, VIP
4	butyrate32	17.6	RET, PCNA, RB1, VIM, VDR, MYC
5	superoxide32 18	18.6	PIK3CA, PIK3C2A, SFN, RB1, LPO, RAP1A
6	actinomycin d32	17.2	PIK3CA, PIK3CG, RETN, KIT, RB1, SELE
7	arginine32	17.0	PIK3CA, PIK3C2A, RECK, RET, CNR2, PCSK2
8	5fluorouracil32	16.0	PIK3CA, PIK3CG, KIT, PCNA, RB1, SELE
9	lactate32	15.9	PIK3CA, PIK3C2A, NCAM1, RECK, KIT, PCNA
10	agar32	15.5	PIK3CA, RET, RB1, VIM, BRAF, MYCN
11	glutamine32	15.1	PIK3CG, NCAM1, KIT, PCNA, VIM, VIP
12	aspartate32	15.1	PIK3C2A, RET, RETN, PCNA, SELP, VIM
13	etoposide32 42 9 9	17.9	PIK3CA, PIK3CG, RECK, PCNA, RB1, SELE
14	dopamine32 9 18 9	17.7	PIK3CA, NCAM1, RET, SELE, VIP, LMOD1
15	indomethacin32 9 9	16.6	PCNA, VIM, VIP, MYC, BMP6, RAF1
16	ag 147832	13.9	PIK3CA, PIK3CG, RAF1, BAK1, JUN, CDK2
17	h2o232	13.4	PIK3CG, SERPINA1, VIP, LPO, RAN, UTS2
18	phospholipid32	13.4	SERPINA1, CLU, SCT, MUC1, MT-CYB, S100A1
19	carbohydrates32	13.0	RECK, SELE, SELP, BSG, LGALS1, LGALS3
20	cytochalasin d32 42	13.9	PIK3CG, SELE, VIM, RAF1, PAK1, BCAR1
21	geldanamycin32 9 9	14.9	PIK3CG, BRAF, VEGFA, RAF1, BIRC5, PARP1
22	quercetin32 42 9 18 9	16.8	PIK3CA, PIK3C2A, PIK3CG, SELE, LPO, RAF1
23	troglitazone32 42 9 9	15.7	PIK3CG, RB1, SELE, VDR, BMP6, RARA
24	polysaccharide32	12.6	NCAM1, RECK, SELE, SELP, SERPINA1, BMP6
25	lactacystin32	12.6	PIK3CG, SELE, VDR, MYC, MYCN, RAF1
26	cytarabine32 34 9 9	15.5	KIT, PCNA, RB1, VIM, MYC, LIF
27	catecholamine32	12.4	PIK3C2A, RET, VIM, MYCN, SDHB, SDHD
28	methylcellulose32	12.4	KIT, LIF, CDH1, FGF2, IL1A, IL6
29	batimastat32 42 9 9	15.3	CD36, MMP1, MMP11, MMP14, MMP15, MMP16
30	anisomycin32 42 9 9	15.0	PIK3CG, MYC, RAF1, BDNF, MTOR, CFLAR
31	corticosterone32 18	13.0	VIP, LIF, BGLAP, BDNF, LEPR, FOS
32	daunorubicin32 9 9	14.0	LPO, MYC, RAF1, BIRC5, BCL2, BCL2L1
33	caffeine32 34 9 18 9	15.9	PCNA, VIP, VDR, BMP6, BGLAP, CHGA
34	cytosine32 18	12.9	SERPINB5, RASSF1, CDH1, APC, TXNRD2, TNFSF10
35	17-(allylamino)-17-demethoxygeldanamycin32	11.9	KIT, BRAF, RAF1, BIRC5, CDK6, CDKN1A
36	inositol32	11.7	BDNF, CHGA, LBR, MINPP1, INSR, FGF1
37	c2ceramide32	11.7	PIK3CG, PARP1, BCL2L1, BAX, JUN, IL1B
38	tpck32	11.6	PIK3CG, PARP1, BCL2L1, BAK1, JUN, IL1B
39	sialic acid32	11.5	NCAM1, RECK, LPO, CLU, LGALS1, S100B
40	vinblastine32 9 9	13.5	BUB1B, VIM, RAF1, BIRC5, BDNF, KDR
41	carboplatin32 34 9 9	14.2	RB1, VEGFA, LIF, PARP1, KDR, BCL2
42	sp 60012532 42	12.1	PIK3CG, BIK, CDKN1A, MMP1, CASP3, AKT1
43	sodium nitroprusside32	11.0	PIK3C2A, PCNA, VIP, BMP6, S100B, FASLG
44	verapamil32 34 9 18 9	15.0	LRP1, RECK, VIP, MYC, UTS2, CDH1
45	temozolomide32 9 9	13.0	PCNA, VIM, VEGFA, PARP1, XRCC1, CDKN1A
46	gsno32	10.9	SELP, CEBPB, JUN, CDKN3, FN1, INSR
47	3,3-diindolylmethane32	10.8	VEGFA, BIRC5, PARP1, BAX, CFLAR, CDK6
48	polyethylene glycol32	10.7	SELE, VIP, MUC1, CDH1, FN1, INSR
49	2-deoxyglucose32	10.4	PIK3CG, FOS, INS, INSR, GRP, ANXA5
50	taxane32	9.6	VEGFA, BIRC5, KDR, BCL2, MTOR, MTHFR

Cellular components related to thyroid carcinoma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	18.2	PIK3CA, PIK3C2A, PIK3CG, PDE1C, KIF23, PCM1
2	extracellular region	GO:005576	17.8	NCAM1, RETN, SERPINA1, VIP, VEGFA, VEGFC
3	extracellular space	GO:005615	16.7	KIT, SFN, PCSK2, SELE, SELP, SERPINB5
4	integral to plasma membrane	GO:005887	15.8	LRP1, RET, CNR2, SELP, KDR, SCTR
5	nucleoplasm	GO:005654	14.6	KIF23, PCNA, RB1, VHL, VDR, LMNB1
6	cell surface	GO:009986	12.9	NCAM1, VEGFA, RARA, LGALS1, AXL, MSN
7	external side of plasma membrane	GO:009897	12.1	NCAM1, KIT, SELP, KDR, S1PR1, CD36
8	platelet alpha granule lumen	GO:031093	11.1	SERPINA1, VEGFA, VEGFC, CLU, FN1, FIGF
9	plasma membrane	GO:005886	INF	PIK3C2A, PIK3CG, NCAM1, RECK, CNR2, KIT
10	nucleus	GO:005634	INF	ZNF20, ZNF121, PIK3C2A, LRP1, NCOA4, KIT
11	cytoplasm	GO:005737	INF	PIK3C2A, PIK3CG, LRP1, KIT, SFN, PCNA

Biological processes related to thyroid carcinoma according to GeneDecks:

(show top 50)    (show all 75)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	18.0	PDE1C, RET, KIT, SFN, VEGFC, VDR
2	apoptotic process	GO:006915	16.1	SFN, BUB1, BUB1B, VIM, LMNB1, RASSF5
3	negative regulation of cell proliferation	GO:008285	14.9	SFN, VHL, VDR, RARG, RARB, RAF1
4	positive regulation of transcription, DNA-dependent	GO:045893	14.5	NCOA4, RET, RB1, NAA15, VHL, MYC
5	negative regulation of transcription, DNA-dependent	GO:045892	14.4	RB1, VDR, BMP7, RARA, BIRC5, BCL6
6	negative regulation of transcription from RNA polymerase II promoter	GO:000122	14.4	VHL, VDR, MYC, RARG, RARB, PARP1
7	blood coagulation	GO:007596	14.3	PIK3CA, PIK3CG, KIF23, SELP, SERPINA1, BSG
8	anti-apoptosis	GO:006916	14.0	PIK3CA, BRAF, VHL, BIRC5, BDNF, BCL2
9	cell proliferation	GO:008283	14.0	SFN, PCNA, BUB1, BUB1B, RAF1, RAP1B
10	response to drug	GO:042493	13.9	VEGFC, MYC, UTS2, BGLAP, BDNF, BCL2
11	negative regulation of apoptotic process	GO:043066	13.9	PIK3CG, BRAF, VEGFA, MYC, RAF1, CLU
12	positive regulation of transcription from RNA polymerase II promoter	GO:045944	13.8	RB1, VEGFA, VDR, MYC, MYCN, BMP6
13	positive regulation of cell proliferation	GO:008284	13.8	KIT, VIP, VEGFA, VEGFC, MYC, RARA
14	response to hypoxia	GO:001666	13.6	SERPINA1, VEGFA, RAF1, UTS2, PAK1, BCL2
15	positive regulation of apoptotic process	GO:043065	13.4	RARG, RARB, CLU, BCL6, BAK1, BAX
16	nerve growth factor receptor signaling pathway	GO:048011	13.2	PIK3CA, PDE1C, BRAF, RAP1A, RAF1, RAPGEF1
17	platelet activation	GO:030168	13.1	PIK3CA, PIK3CG, SELP, SERPINA1, VEGFA, VEGFC
18	angiogenesis	GO:001525	13.0	PIK3CA, PIK3CG, NAA15, VEGFA, VEGFC, KDR
19	negative regulation of neuron apoptotic process	GO:043524	13.0	BRAF, RASA1, BDNF, BCL2, BCL2L1, CITED1
20	epidermal growth factor receptor signaling pathway	GO:007173	12.7	PIK3CA, PIK3C2A, PDE1C, RAF1, BCAR1, MTOR
21	cell-cell signaling	GO:007267	12.6	S100A9, CD86, CD80, CD97, AR, INS
22	Ras protein signal transduction	GO:007265	12.5	RB1, RAF1, RASSF1, CDKN1A, CDK2, CDKN2A
23	heart development	GO:007507	12.5	PCNA, RAF1, ATM, CASP3, CASP8, HOPX
24	fibroblast growth factor receptor signaling pathway	GO:008543	12.5	PIK3CA, PDE1C, BRAF, RAF1, MTOR, CDKN1B
25	response to lipopolysaccharide	GO:032496	12.3	CNR2, SELE, SELP, SERPINA1, CITED1, S100A8
26	mitotic cell cycle	GO:000278	12.3	KIF23, PCNA, PCM1, BUB1, BUB1B, RB1
27	cell cycle arrest	GO:007050	12.3	RB1, MYC, RASSF1, ATM, CDK6, CDKN1A
28	platelet degranulation	GO:002576	12.3	SELP, SERPINA1, VEGFA, VEGFC, CLU, CD36
29	positive regulation of peptidyl-serine phosphorylation	GO:033138	12.2	PIK3CA, BRAF, VEGFA, RAF1, LIF, PAK1
30	inflammatory response	GO:006954	12.0	PIK3CG, CNR2, KIT, SELE, SELP, BMP6
31	MAPK cascade	GO:000165	12.0	RET, MYC, RAF1, PAK1, CDK1, INS
32	positive regulation of ERK1 and ERK2 cascade	GO:070374	12.0	BRAF, KDR, CD44, FGF2, FGFR3, FGFR4
33	positive regulation of cell migration	GO:030335	11.9	RET, VEGFA, KDR, BCAR1, S1PR1, ITGB1
34	protein autophosphorylation	GO:046777	11.8	KIT, PAK1, KDR, MTOR, AURKA, AURKB
35	positive regulation of angiogenesis	GO:045766	11.8	VEGFA, UTS2, KDR, MMP9, FLT1, FGF1
36	G1/S transition of mitotic cell cycle	GO:000082	11.7	PCNA, RB1, BCL2, CKS1B, CDK6, CDKN1A
37	response to organic cyclic compound	GO:014070	11.5	SELP, SERPINA1, BAK1, JUN, CDKN1A, CDK1
38	phosphatidylinositol-mediated signaling	GO:048015	11.4	PIK3CA, PIK3C2A, PCNA, BUB1B, UBE2C, MTOR
39	positive regulation of fibroblast proliferation	GO:048146	11.3	MYC, UTS2, S100A6, JUN, CDK6, CDKN1A
40	positive regulation of protein phosphorylation	GO:001934	11.3	VEGFA, MTOR, INSR, FGF1, IL1B, FAM129A
41	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	11.3	KIT, SELP, KDR, FLT1, INS, FGFR1
42	positive regulation of MAPK cascade	GO:043410	11.2	KIT, LIF, KDR, LEP, CD36, CDH2
43	activation of MAPKK activity	GO:000186	11.2	RAF1, NTRK1, NRAS, CRK
44	activation of MAPK activity	GO:000187	11.2	KIT, CDK1, IRAK1, INSR, FGF2, MET
45	response to estradiol stimulus	GO:032355	11.1	SERPINA1, VDR, RARA, AURKA, MMP15, MMP9
46	insulin receptor signaling pathway	GO:008286	11.1	PIK3CA, PIK3C2A, RAF1, BCAR1, MTOR, CDK1
47	positive regulation of smooth muscle cell proliferation	GO:048661	11.0	S1PR1, JUN, FLT1, IL6, IL6R, IGF1
48	aging	GO:007568	10.9	VDR, BAK1, JUN, IL1B, FAS, CCL2
49	positive regulation of protein kinase B signaling cascade	GO:051897	10.6	PIK3CG, MTOR, AXL, INS, INSR, ILK
50	response to ethanol	GO:045471	10.4	BGLAP, BCL2, BAK1, S100A8, S100A9, CDK1

Molecular functions related to thyroid carcinoma according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	GAS6, GAB1, GAPDH, EPOR, EPO, EPCAM
2	ATP binding	GO:005524	14.3	NME1, RUNX3, PRKCA, DCK, STK11, TGFBR2
3	protein homodimerization activity	GO:042803	14.0	HPGD, JUP, JUN, MSH3, CEBPB, QPRT
4	identical protein binding	GO:042802	14.0	BAX, PCNA, PCM1, VIM, RAF1, BAK1
5	growth factor activity	GO:008083	13.4	GDNF, GDF15, HGF, CSF3, PDGFB, PDGFA
6	protein heterodimerization activity	GO:046982	13.3	HIF1A, EGFR, PDGFB, PDGFA, TP53, ERBB2
7	protein kinase binding	GO:019901	12.8	PTEN, TP53, TRAF6, CCND1, CCND3, CCNA2
8	transcription regulatory region DNA binding	GO:044212	11.7	HIF1A, NFKB1, PHB, SMAD6, SMAD4, AHR
9	cytokine activity	GO:005125	11.5	TNFRSF11B, TNFSF10, TNFSF11, SPP1, NRG1, EDN1
10	hormone activity	GO:005179	11.5	GAST, CALCA, IAPP, IGF1, CCK, INSL3
11	transmembrane receptor protein tyrosine kinase activity	GO:004714	11.4	TRIM27, TEK, DDR2, NTRK1, NTRK3, EGFR
12	transcription factor binding	GO:008134	11.2	TP53, TNFRSF10A, SP1, CTNNB1, HIF1A, AHR
13	protein kinase activity	GO:004672	10.9	PTK2, TEK, TRIM24, AKT3, AKT1, DAPK1
14	protein tyrosine kinase activity	GO:004713	10.5	ERBB3, ERBB4, ERBB2, TEK, SRC, PDGFRB
15	enzyme binding	GO:019899	INF	PTEN, IL6R, AR, MSH3, BIRC5, RARA
16	receptor binding	GO:005102	INF	FASLG, RARA, RASA1, UTS2, GRP, INSL3