MCID: THY095
MIFTS: 55

Thyroid Carcinoma, Follicular malady

Genetic diseases, Rare diseases, Endocrine diseases, Cancer diseases categories

Aliases & Classifications for Thyroid Carcinoma, Follicular

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Aliases & Descriptions for Thyroid Carcinoma, Follicular:

Name: Thyroid Carcinoma, Follicular 46 9 42
Follicular Thyroid Carcinoma 8 42 61
Thyroid Follicular Carcinoma 44 22
Thyroid Cancer, Follicular 42 61
Follicular Adenocarcinoma, Well Differentiated 8
Follicular Carcinoma of the Thyroid Gland 8
Thyroid Carcinoma, Follicular, Somatic 46
 
Thyroid Gland Adenocarcinoma 61
Follicular Adenocarcinoma 8
Follicular Thyroid Cancer 44
Thyroid Adenocarcinoma 8
Follicular Carcinoma 8
Ftc 42


Classifications:



External Ids:

OMIM46 188470
Disease Ontology8 DOID:3962
NCIt39 C8054
MeSH33 D018263

Summaries for Thyroid Carcinoma, Follicular

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OMIM:46 Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95%... (188470) more...

MalaCards based summary: Thyroid Carcinoma, Follicular, also known as follicular thyroid carcinoma, is related to neuroblastoma and goiter, and has symptoms including autosomal dominant inheritance, abnormality of metabolism/homeostasis and follicular thyroid carcinoma. An important gene associated with Thyroid Carcinoma, Follicular is NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog), and among its related pathways are Long-term depression and Signalling to ERKs. The compounds panitumumab and gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and lymph node, and related mouse phenotypes are limbs/digits/tail and liver/biliary system.

Disease Ontology:8 A thyroid carcinoma that has material basis in follicular cells.

Wikipedia:64 Follicular thyroid cancer accounts for 15% of thyroid cancer and occurs more commonly in women over 50... more...

Related Diseases for Thyroid Carcinoma, Follicular

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Diseases related to Thyroid Carcinoma, Follicular via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1neuroblastoma30.8AKT1
2goiter30.7RET, BRAF
3pancreatitis30.5HRAS, NRAS, KRAS
4papillary carcinoma30.4HRAS, BRAF, RET
5adenomatous polyposis coli30.1NRAS, KRAS, BRAF
6thyroid carcinoma, papillary30.0PTEN, BRAF, HRAS, RET
7sarcoma30.0BRAF, HRAS, KRAS, NRAS
8medullary thyroid carcinoma, familial29.9RET, BRAF
9follicular adenoma29.8BRAF, PTEN, HRAS, RET
10adenoma29.8BRAF, KRAS, RET, HRAS, NRAS
11thyroid adenoma29.7PIK3CA, RET, BRAF, PTEN
12thyroid cancer29.5PIK3CA, RET, HRAS, PTEN, BRAF
13adenocarcinoma29.3AKT1, HRAS, KRAS, PIK3CA, PTEN, BRAF
14thyroiditis10.8
15leopard syndrome10.5HRAS
16hyperthyroidism10.5
17cowden syndrome 110.5PTEN
18pilocytic astrocytoma10.5PTEN
19mediastinitis10.5
20proteus syndrome, somatic10.5PTEN
21lipomatosis10.4PTEN
22multinodular goiter10.4
23cervicitis10.4
24thyrotoxicosis10.4
25familial papillary or follicular thyroid carcinoma10.4
26choroiditis10.3
27graves' disease10.3
28back pain10.3
29endotheliitis10.3
30bone marrow cancer10.3NRAS, KRAS
31thyroid carcinoma, hurthle cell10.3
32bannayan-riley-ruvalcaba syndrome10.3MINPP1, PTEN
33papillary follicular thyroid adenocarcinoma10.2
34large cell carcinoma10.2HRAS, KRAS
35gastric cancer, somatic10.2KRAS, PIK3CA
36exanthem10.2HRAS, KRAS, NRAS
37leukemia, juvenile myelomonocytic10.2HRAS, NRAS, KRAS
38gallbladder cancer10.2KRAS, NRAS, HRAS
39pleuropulmonary blastoma10.2
40hematopoietic stem cell transplantation10.2
41myasthenia gravis10.2
42sinusitis10.2
43subacute thyroiditis10.2
44olfactory neuroblastoma10.2
45blastoma10.2
46thrombocytosis10.2
47acromegaly10.2
48situs inversus10.2
49primary hyperparathyroidism10.2
50down syndrome10.2

Graphical network of the top 20 diseases related to Thyroid Carcinoma, Follicular:



Diseases related to thyroid carcinoma, follicular

Symptoms for Thyroid Carcinoma, Follicular

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Symptoms by clinical synopsis from OMIM:

188470

Clinical features from OMIM:

188470

HPO human phenotypes related to Thyroid Carcinoma, Follicular:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of metabolism/homeostasis HP:0001939
3 follicular thyroid carcinoma HP:0006731

Drugs & Therapeutics for Thyroid Carcinoma, Follicular

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Drug clinical trials:

Search ClinicalTrials for Thyroid Carcinoma, Follicular

Search NIH Clinical Center for Thyroid Carcinoma, Follicular

Genetic Tests for Thyroid Carcinoma, Follicular

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Genetic tests related to Thyroid Carcinoma, Follicular:

id Genetic test Affiliating Genes
1 Thyroid Cancer, Follicular22

Anatomical Context for Thyroid Carcinoma, Follicular

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MalaCards organs/tissues related to Thyroid Carcinoma, Follicular:

31
Thyroid, Bone, Lymph node, Lung

Animal Models for Thyroid Carcinoma, Follicular or affiliated genes

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MGI Mouse Phenotypes related to Thyroid Carcinoma, Follicular:

35 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.4PTEN, RET, NRAS, KRAS
2MP:00053708.4AKT1, BRAF, KRAS, PTEN, NRAS
3MP:00053758.2PIK3CA, PTEN, BRAF, AKT1
4MP:00053918.1KRAS, NRAS, BRAF, PTEN, PIK3CA
5MP:00053678.0HRAS, RET, KRAS, PTEN, BRAF
6MP:00053818.0KRAS, NRAS, RET, BRAF, PTEN
7MP:00053887.7RET, PTEN, BRAF, AKT1, KRAS, HRAS
8MP:00107717.6PIK3CA, PTEN, BRAF, AKT1, NRAS, KRAS
9MP:00053697.4BRAF, KRAS, RET, AKT1, PIK3CA, PTEN
10MP:00053977.3AKT1, RET, NRAS, KRAS, BRAF, PTEN
11MP:00053897.3BRAF, PIK3CA, AKT1, RET, PTEN, KRAS
12MP:00053807.1PTEN, RET, AKT1, BRAF, KRAS, PIK3CA
13MP:00053797.1AKT1, KRAS, PTEN, PIK3CA, HRAS, RET
14MP:00028737.1NRAS, PTEN, AKT1, BRAF, KRAS, MINPP1
15MP:00053877.0KRAS, RET, AKT1, BRAF, PTEN, PIK3CA
16MP:00053867.0PTEN, BRAF, AKT1, RET, KRAS, HRAS
17MP:00053847.0PIK3CA, KRAS, NRAS, RET, BRAF, AKT1
18MP:00036317.0HRAS, PTEN, PIK3CA, KRAS, RET, AKT1
19MP:00020066.8KRAS, HRAS, NRAS, RET, AKT1, BRAF
20MP:00053856.8KRAS, HRAS, PIK3CA, PTEN, RET, BRAF
21MP:00053786.8PIK3CA, PTEN, BRAF, AKT1, RET, NRAS
22MP:00053766.8PTEN, BRAF, AKT1, PIK3CA, HRAS, KRAS
23MP:00107686.7PIK3CA, PTEN, BRAF, AKT1, RET, NRAS

Publications for Thyroid Carcinoma, Follicular

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Articles related to Thyroid Carcinoma, Follicular:

idTitleAuthorsYear
1
Comparison of proliferating cell nuclear antigen, thyroid transcription factor-1, Ki-67, p63, p53 and high-molecular weight cytokeratin expressions in papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. (21315633)
2011
2
Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. (20526288)
2010
3
Hyperfunctioning thyroid adenoma concomitant with papillary thyroid carcinoma, follicular thyroid adenoma and primary hyperparathyroidism. (9625447)
1998

Variations for Thyroid Carcinoma, Follicular

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Clinvar genetic disease variations for Thyroid Carcinoma, Follicular:

5
id Gene Variation Type Significance SNP ID Assembly Location
1HRASNM_005343.2(HRAS): c.181C> A (p.Gln61Lys)single nucleotide variantPathogenicrs28933406GRCh37Chr 11, 533875: 533875
2NRASNM_002524.4(NRAS): c.182A> G (p.Gln61Arg)single nucleotide variantPathogenicrs11554290GRCh37Chr 1, 115256529: 115256529
3BRAFNM_004333.4(BRAF): c.1801A> G (p.Lys601Glu)single nucleotide variantPathogenicrs121913364GRCh37Chr 7, 140453134: 140453134
4MINPP1NM_004897.4(MINPP1): c.122C> T (p.Ser41Leu)single nucleotide variantPathogenicrs119486096GRCh37Chr 10, 89264794: 89264794
5MINPP1NM_004897.4(MINPP1): c.809A> G (p.Gln270Arg)single nucleotide variantPathogenicrs104894171GRCh37Chr 10, 89268264: 89268264

Cosmic variations for Thyroid Carcinoma, Follicular:

6 (show all 128)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1778PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
21666844PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
3760PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
433600PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
529110PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
617446PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
729097PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
833601PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
929329PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
1029106PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
1112597PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
12759PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
1329108PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
14775PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
1533599PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
1629096PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
1728544PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
1827133PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
1917443PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
2012458PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
2133598PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
22763PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
2329095PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
24527KRASthyroid,NS,carcinoma,papillary carcinoma3
25522KRASthyroid,NS,carcinoma,follicular carcinoma3
26518KRASthyroid,NS,carcinoma,follicular carcinoma3
27528KRASthyroid,NS,carcinoma,papillary carcinoma3
2826146KRASthyroid,NS,carcinoma,papillary carcinoma3
29548KRASthyroid,NS,carcinoma,papillary carcinoma3
30529KRASthyroid,NS,carcinoma,papillary carcinoma3
31551KRASthyroid,NS,carcinoma,follicular carcinoma3
32552KRASthyroid,NS,carcinoma,follicular carcinoma3
33521KRASthyroid,NS,carcinoma,papillary carcinoma3
34517KRASthyroid,NS,carcinoma,papillary carcinoma3
35533KRASthyroid,NS,carcinoma,papillary carcinoma3
36516KRASthyroid,NS,carcinoma,papillary carcinoma3
37520KRASthyroid,NS,carcinoma,papillary carcinoma3
38549KRASthyroid,NS,carcinoma,papillary carcinoma3
39532KRASthyroid,NS,carcinoma,follicular carcinoma3
40485HRASthyroid,NS,carcinoma,papillary carcinoma3
41486HRASthyroid,NS,carcinoma,papillary carcinoma3
42490HRASthyroid,NS,carcinoma,papillary carcinoma3
433736923HRASthyroid,NS,carcinoma,follicular carcinoma3
44500HRASthyroid,NS,carcinoma,follicular carcinoma3
45480HRASthyroid,NS,carcinoma,papillary carcinoma3
46488HRASthyroid,NS,carcinoma,papillary carcinoma3
47110720HRASthyroid,NS,carcinoma,papillary carcinoma3
48481HRASthyroid,NS,carcinoma,papillary carcinoma3
49483HRASthyroid,NS,carcinoma,papillary carcinoma3
50482HRASthyroid,NS,carcinoma,papillary carcinoma3
51484HRASthyroid,NS,carcinoma,papillary carcinoma3
52496HRASthyroid,NS,carcinoma,papillary carcinoma3
53503HRASthyroid,NS,carcinoma,follicular carcinoma3
54498HRASthyroid,NS,carcinoma,follicular carcinoma3
55499HRASthyroid,NS,carcinoma,follicular carcinoma3
56564NRASthyroid,NS,carcinoma,papillary carcinoma3
57586NRASthyroid,NS,carcinoma,papillary carcinoma3
58585NRASthyroid,NS,carcinoma,papillary carcinoma3
59579NRASthyroid,NS,carcinoma,follicular carcinoma3
60573NRASthyroid,NS,carcinoma,papillary carcinoma3
61570NRASthyroid,NS,carcinoma,papillary carcinoma3
62562NRASthyroid,NS,carcinoma,papillary carcinoma3
63583NRASthyroid,NS,carcinoma,papillary carcinoma3
64584NRASthyroid,NS,carcinoma,follicular carcinoma3
65580NRASthyroid,NS,carcinoma,follicular carcinoma3
6628049NRASthyroid,NS,carcinoma,follicular carcinoma3
6728048NRASthyroid,NS,carcinoma,papillary carcinoma3
6810834TP53thyroid,NS,carcinoma,papillary carcinoma3
6943624TP53thyroid,NS,carcinoma,follicular carcinoma3
70144150TP53thyroid,NS,carcinoma,follicular carcinoma3
7143981TP53thyroid,NS,carcinoma,papillary carcinoma3
7243980TP53thyroid,NS,carcinoma,papillary carcinoma3
7310739TP53thyroid,NS,carcinoma,papillary carcinoma3
7443979TP53thyroid,NS,carcinoma,papillary carcinoma3
7510656TP53thyroid,NS,carcinoma,follicular carcinoma3
7610771TP53thyroid,NS,carcinoma,papillary carcinoma3
7710704TP53thyroid,NS,carcinoma,papillary carcinoma3
7810867TP53thyroid,NS,carcinoma,papillary carcinoma3
7910863TP53thyroid,NS,carcinoma,papillary carcinoma3
8023653PTENthyroid,NS,carcinoma,follicular carcinoma3
8123654PTENthyroid,NS,carcinoma,follicular carcinoma3
8223652PTENthyroid,NS,carcinoma,follicular carcinoma3
8323649PTENthyroid,NS,carcinoma,follicular carcinoma3
845224PTENthyroid,NS,carcinoma,follicular carcinoma3
8523650PTENthyroid,NS,carcinoma,follicular carcinoma3
865092PTENthyroid,NS,carcinoma,papillary carcinoma3
8723651PTENthyroid,NS,carcinoma,follicular carcinoma3
885033PTENthyroid,NS,carcinoma,follicular carcinoma3
895034PTENthyroid,NS,carcinoma,follicular carcinoma3
905759CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
915760CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
925662CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
935706CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
945762CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
955707CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
965761CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
975723CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
9821549BRAFthyroid,NS,carcinoma,papillary carcinoma3
9930671BRAFthyroid,NS,carcinoma,papillary carcinoma3
1001131BRAFthyroid,NS,carcinoma,papillary carcinoma3
10113982BRAFthyroid,NS,carcinoma,papillary carcinoma3
102476BRAFthyroid,NS,carcinoma,papillary carcinoma3
103478BRAFthyroid,NS,carcinoma,papillary carcinoma3
104475BRAFthyroid,NS,carcinoma,papillary carcinoma3
10596532IDH1thyroid,NS,carcinoma,follicular carcinoma3
10696531IDH1thyroid,NS,carcinoma,papillary carcinoma3
10796534IDH1thyroid,NS,carcinoma,papillary carcinoma3
10896533IDH1thyroid,NS,carcinoma,follicular carcinoma3
10997131IDH1thyroid,NS,carcinoma,papillary carcinoma3
11096923IDH1thyroid,NS,carcinoma,papillary carcinoma3
11114193SMAD4thyroid,NS,carcinoma,papillary carcinoma3
11214196SMAD4thyroid,NS,carcinoma,papillary carcinoma3
11314189SMAD4thyroid,NS,carcinoma,papillary carcinoma3
11414186SMAD4thyroid,NS,carcinoma,papillary carcinoma3
11514185SMAD4thyroid,NS,carcinoma,papillary carcinoma3
11620897EGFRthyroid,NS,carcinoma,papillary carcinoma3
11720896EGFRthyroid,NS,carcinoma,papillary carcinoma3
11813182EGFRthyroid,NS,carcinoma,papillary carcinoma3
1196224EGFRthyroid,NS,carcinoma,papillary carcinoma3
12029274EGFRthyroid,NS,carcinoma,papillary carcinoma3
12127899GNASthyroid,NS,carcinoma,papillary carcinoma3
12227887GNASthyroid,NS,carcinoma,papillary carcinoma3
12313224CDKN2Athyroid,NS,carcinoma,follicular carcinoma3
12413292CDKN2Athyroid,NS,carcinoma,papillary carcinoma3
12533765AKT1thyroid,NS,carcinoma,papillary carcinoma3
126786FLT3thyroid,NS,carcinoma,papillary carcinoma3
127707METthyroid,NS,carcinoma,follicular carcinoma3
12817721VHLthyroid,NS,carcinoma,papillary carcinoma3

Expression for genes affiliated with Thyroid Carcinoma, Follicular

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Search GEO for disease gene expression data for Thyroid Carcinoma, Follicular.

Pathways for genes affiliated with Thyroid Carcinoma, Follicular

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Pathways related to Thyroid Carcinoma, Follicular according to GeneCards Suite gene sharing:

(show top 50)    (show all 165)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.8HRAS, KRAS, NRAS, BRAF
2
Show member pathways
8.8HRAS, KRAS, NRAS, BRAF
3
Show member pathways
8.7PIK3CA, HRAS, KRAS, NRAS
48.6PTEN, AKT1, HRAS, PIK3CA
58.5AKT1, BRAF, HRAS, PIK3CA
68.5AKT1, BRAF, PIK3CA, HRAS
78.4PTEN, BRAF, HRAS, NRAS, AKT1
8
Show member pathways
8.4HRAS, AKT1, NRAS, KRAS, PTEN
98.4KRAS, AKT1, HRAS, NRAS, PTEN
10
Show member pathways
8.3BRAF, AKT1, KRAS, HRAS, NRAS
11
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells59
Oncostatin M Signaling Pathway36
8.3KRAS, NRAS, AKT1, BRAF, HRAS
12
Show member pathways
8.2HRAS, PIK3CA, BRAF, NRAS, KRAS
13
Show member pathways
8.2KRAS, HRAS, NRAS, PIK3CA, BRAF
14
Show member pathways
8.2KRAS, NRAS, HRAS, PIK3CA, BRAF
15
Show member pathways
Immune response CD16 signaling in NK cells59
8.2NRAS, HRAS, PIK3CA, KRAS, BRAF
16
Show member pathways
8.1HRAS, AKT1, PIK3CA, KRAS, NRAS
178.1KRAS, AKT1, PIK3CA, HRAS, NRAS
188.1HRAS, KRAS, AKT1, NRAS, PIK3CA
19
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling59
Leptin signaling pathway36
8.1KRAS, NRAS, AKT1, HRAS, PIK3CA
20
Show member pathways
8.1KRAS, AKT1, HRAS, PIK3CA, NRAS
218.0HRAS, KRAS, NRAS, RET, BRAF
22
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
7.8PTEN, HRAS, NRAS, AKT1, BRAF, PIK3CA
23
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
7.7AKT1, NRAS, KRAS, HRAS, PTEN, PIK3CA
24
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
7.7AKT1, PTEN, PIK3CA, HRAS, KRAS, NRAS
25
Show member pathways
7.7HRAS, KRAS, NRAS, AKT1, PTEN, PIK3CA
267.7PTEN, HRAS, AKT1, KRAS, PIK3CA, NRAS
27
Show member pathways
Cytoskeleton remodeling FAK signaling59
Development Endothelin 1 EDNRA transactivation of EGFR59
7.7PIK3CA, KRAS, PTEN, AKT1, HRAS, NRAS
28
Show member pathways
7.7KRAS, PIK3CA, PTEN, NRAS, HRAS, AKT1
29
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
7.7AKT1, PIK3CA, NRAS, HRAS, BRAF, KRAS
30
Show member pathways
Development EDNRB signaling59
Development ACM2 and ACM4 activation of ERK59
Cell adhesion Integrin inside out signaling59
Development G Proteins mediated regulation MARK ERK signaling59
Signal transduction IP3 signaling59
Development Angiotensin signaling via PYK259
Development EPO induced MAPK pathway59
7.7AKT1, BRAF, PIK3CA, NRAS, KRAS, HRAS
31
Show member pathways
7.7NRAS, BRAF, KRAS, HRAS, AKT1, PIK3CA
32
Show member pathways
7.7PIK3CA, BRAF, AKT1, KRAS, HRAS, NRAS
33
Show member pathways
7.7NRAS, HRAS, PIK3CA, BRAF, AKT1, KRAS
347.7PIK3CA, BRAF, AKT1, NRAS, KRAS, HRAS
35
Show member pathways
7.7KRAS, NRAS, PIK3CA, AKT1, BRAF, HRAS
367.7PIK3CA, BRAF, AKT1, NRAS, KRAS, HRAS
377.7PIK3CA, HRAS, KRAS, NRAS, AKT1, BRAF
38
Show member pathways
7.7PIK3CA, HRAS, KRAS, NRAS, AKT1, BRAF
39
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
7.6PTEN, BRAF, HRAS, AKT1, KRAS, PIK3CA
40
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
7.4BRAF, AKT1, NRAS, RET, HRAS, PIK3CA
41
Show member pathways
Signal transduction PTEN pathway59
7.3KRAS, NRAS, AKT1, BRAF, PTEN, PIK3CA
42
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
7.3BRAF, HRAS, KRAS, NRAS, AKT1, PTEN
43
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
7.3PIK3CA, AKT1, BRAF, NRAS, KRAS, HRAS
44
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
7.3NRAS, KRAS, PIK3CA, PTEN, BRAF, AKT1
457.3HRAS, KRAS, NRAS, AKT1, BRAF, PIK3CA
46
Show member pathways
Immune response BCR pathway59
Fc-epsilon receptor I signaling in mast cells36
7.3PIK3CA, BRAF, AKT1, NRAS, KRAS, HRAS
47
Show member pathways
7.3PIK3CA, HRAS, BRAF, KRAS, NRAS, PTEN
48
Show member pathways
Signaling Pathways in Glioblastoma36
7.3PIK3CA, KRAS, HRAS, NRAS, AKT1, BRAF
49
Show member pathways
6.9BRAF, HRAS, KRAS, NRAS, RET, AKT1
506.5KRAS, HRAS, RET, AKT1, BRAF, PTEN

Compounds for genes affiliated with Thyroid Carcinoma, Follicular

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Compounds related to Thyroid Carcinoma, Follicular according to GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1panitumumab44 50 1111.5PTEN, KRAS, BRAF
2gemcitabine44 50 1111.5AKT1, PTEN, HRAS
3farnesyl diphosphate44 28 1111.4HRAS, AKT1, KRAS
4cetuximab44 50 1111.4KRAS, BRAF, PTEN
5sodium iodide449.4RET, BRAF
6ptdins(3)p449.3PIK3CA, AKT1
7erlotinib44 50 1111.2PTEN, KRAS, PIK3CA
8phosphatidylinositol-3,4,5-trisphosphate44 2410.1PTEN, AKT1, PIK3CA
9quercetin44 60 24 1112.0AKT1, PTEN, PIK3CA
10regorafenib50 1110.0RET, KRAS, BRAF
11herbimycin a44 609.9AKT1, RET, HRAS
12inositol448.9MINPP1, AKT1, PTEN, PIK3CA
13doxorubicin44 50 1110.9AKT1, HRAS, PIK3CA, PTEN
14arsenite44 249.8PTEN, PIK3CA, AKT1
15gefitinib44 50 1110.8PTEN, PIK3CA, KRAS, AKT1
16progesterone44 28 60 24 1112.7HRAS, BRAF, PTEN, PIK3CA
17cyclic amp44 249.6PTEN, BRAF, HRAS, RET
18ceramide448.6PIK3CA, AKT1, PTEN
19phosphotyrosine448.6HRAS, PTEN, RET, PIK3CA
20crcs448.6KRAS, BRAF, PTEN, PIK3CA, HRAS
21leucine448.5RET, PIK3CA, PTEN, HRAS
22glucose448.4AKT1, HRAS, BRAF, PTEN, PIK3CA
23h2o2448.4PIK3CA, HRAS, KRAS, AKT1, PTEN
24gtp44 289.4KRAS, BRAF, PIK3CA, AKT1, HRAS
25aspartate448.3RET, HRAS, AKT1, PTEN, BRAF
26valine448.2BRAF, AKT1, RET, HRAS, KRAS
27genistein44 28 60 1 24 1113.1HRAS, RET, PTEN, AKT1, PIK3CA
28atp44 289.1HRAS, RET, BRAF, PTEN, PIK3CA
29testosterone44 60 24 1111.1PTEN, AKT1, RET, PIK3CA
30imatinib44 50 1110.1PIK3CA, PTEN, BRAF, RET, KRAS
31paclitaxel44 50 1110.0BRAF, HRAS, KRAS, AKT1, PTEN, PIK3CA
32rapamycin448.0AKT1, PIK3CA, BRAF, KRAS, HRAS, PTEN
33phosphoinositide448.0AKT1, KRAS, BRAF, PTEN, HRAS, PIK3CA
34cisplatin44 50 60 1111.0HRAS, AKT1, PTEN, PIK3CA, BRAF, KRAS
35oligonucleotide448.0KRAS, HRAS, PTEN, NRAS, BRAF, RET
36estrogen448.0PIK3CA, PTEN, AKT1, BRAF, KRAS, HRAS
37adp44 28 249.9PIK3CA, RET, PTEN, BRAF, AKT1
38paraffin447.8BRAF, KRAS, RET, AKT1, PTEN, HRAS
39pd 98,059447.7HRAS, RET, AKT1, PTEN, PIK3CA, BRAF
40arginine447.7PIK3CA, HRAS, RET, BRAF, AKT1, PTEN
41threonine447.7BRAF, AKT1, RET, HRAS, PTEN, PIK3CA
42agar447.4PTEN, HRAS, RET, NRAS, AKT1, BRAF
43ly294002447.2BRAF, PTEN, PIK3CA, HRAS, AKT1, RET
44wortmannin447.2RET, AKT1, PIK3CA, BRAF, HRAS, KRAS
45vegf447.2KRAS, RET, AKT1, BRAF, HRAS, PTEN
46phosphatidylinositol447.2RET, KRAS, AKT1, PIK3CA, PTEN, BRAF
47retinoic acid44 248.2PIK3CA, BRAF, AKT1, RET, KRAS, HRAS
48lipid447.2HRAS, KRAS, PIK3CA, PTEN, BRAF, AKT1
49serine447.2KRAS, RET, AKT1, BRAF, PTEN, PIK3CA
50tyrosine446.9PTEN, HRAS, PIK3CA, NRAS, KRAS, RET

GO Terms for genes affiliated with Thyroid Carcinoma, Follicular

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Cellular components related to Thyroid Carcinoma, Follicular according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058867.3HRAS, KRAS, NRAS, AKT1, BRAF, PTEN

Biological processes related to Thyroid Carcinoma, Follicular according to GeneCards Suite gene sharing:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1regulation of neuron projection developmentGO:00109759.8PTEN, AKT1
2negative regulation of cell sizeGO:00457929.8PTEN, AKT1
3inositol phosphate metabolic processGO:00436479.7PTEN, MINPP1
4positive regulation of Rac protein signal transductionGO:00350229.7HRAS, KRAS, NRAS
5regulation of synaptic transmission, GABAergicGO:00322289.7KRAS, NRAS, HRAS
6regulation of long-term neuronal synaptic plasticityGO:00481699.6KRAS, HRAS, NRAS
7visual learningGO:00085429.6HRAS, NRAS, KRAS
8positive regulation of nitric-oxide synthase activityGO:00510009.6AKT1, KRAS
9Ras protein signal transductionGO:00072659.6HRAS, KRAS, NRAS
10endothelial cell migrationGO:00435429.6PTEN, PIK3CA
11GTP catabolic processGO:00061849.5HRAS, NRAS, KRAS
12social behaviorGO:00351769.5HRAS, KRAS, PTEN
13positive regulation of MAP kinase activityGO:00434069.5HRAS, KRAS
14actin cytoskeleton organizationGO:00300369.5HRAS, KRAS, NRAS
15positive regulation of protein phosphorylationGO:00019349.4AKT1, HRAS, KRAS
16axon guidanceGO:00074119.4KRAS, NRAS, HRAS
17protein kinase B signalingGO:00434919.3PTEN, PIK3CA, AKT1
18activation of MAPKK activityGO:00001869.2KRAS, HRAS, NRAS, BRAF
19cell proliferationGO:00082839.2AKT1, PTEN, HRAS
20positive regulation of peptidyl-serine phosphorylationGO:00331389.2PIK3CA, BRAF, AKT1
21striated muscle cell differentiationGO:00511469.2NRAS, KRAS, AKT1, HRAS
22positive regulation of cell proliferationGO:00082849.1PTEN, HRAS, KRAS, NRAS
23small GTPase mediated signal transductionGO:00072649.1NRAS, KRAS, HRAS, BRAF
24phosphatidylinositol-mediated signalingGO:00480159.1PTEN, AKT1, PIK3CA
25leukocyte migrationGO:00509009.0KRAS, PIK3CA, NRAS, HRAS
26MAPK cascadeGO:00001658.8KRAS, HRAS, RET, NRAS
27negative regulation of neuron apoptotic processGO:00435248.6PIK3CA, BRAF, NRAS, KRAS, HRAS
28insulin receptor signaling pathwayGO:00082868.5PIK3CA, AKT1, NRAS, KRAS, HRAS
29blood coagulationGO:00075968.5NRAS, PIK3CA, KRAS, HRAS, AKT1
30protein phosphorylationGO:00064688.4RET, BRAF, AKT1
31Fc-epsilon receptor signaling pathwayGO:00380958.1PTEN, NRAS, HRAS, PIK3CA, KRAS, AKT1
32epidermal growth factor receptor signaling pathwayGO:00071738.1HRAS, KRAS, NRAS, PTEN, PIK3CA, AKT1
33innate immune responseGO:00450878.1NRAS, KRAS, HRAS, AKT1, PTEN, PIK3CA
34fibroblast growth factor receptor signaling pathwayGO:00085437.7BRAF, PTEN, AKT1, NRAS, KRAS, PIK3CA
35neurotrophin TRK receptor signaling pathwayGO:00480117.7NRAS, PTEN, BRAF, PIK3CA, AKT1, KRAS

Molecular functions related to Thyroid Carcinoma, Follicular according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:00163019.0AKT1, PIK3CA
2protein serine/threonine kinase activityGO:00046748.9AKT1, BRAF, PIK3CA
3protein bindingGO:00055156.7HRAS, PIK3CA, PTEN, BRAF, AKT1, RET

Sources for Thyroid Carcinoma, Follicular

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet