MCID: THY095
MIFTS: 55

Thyroid Carcinoma, Follicular malady

Genetic diseases, Rare diseases, Endocrine diseases, Cancer diseases categories

Summaries for Thyroid Carcinoma, Follicular

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OMIM:45 Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95%... (188470) more...

MalaCards based summary: Thyroid Carcinoma, Follicular, also known as follicular thyroid carcinoma, is related to neuroblastoma and goiter, and has symptoms including autosomal dominant inheritance, abnormality of metabolism/homeostasis and follicular thyroid carcinoma. An important gene associated with Thyroid Carcinoma, Follicular is NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog), and among its related pathways are Long-term depression and Signalling to ERKs. The compounds panitumumab and gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and lymph node, and related mouse phenotypes are limbs/digits/tail and liver/biliary system.

Disease Ontology:9 A thyroid carcinoma that has material basis in follicular cells.

Wikipedia:63 Follicular thyroid cancer accounts for 15% of thyroid cancer and occurs more commonly in women over 50... more...

Aliases & Classifications for Thyroid Carcinoma, Follicular

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Thyroid Carcinoma, Follicular, Aliases & Descriptions:

Name: Thyroid Carcinoma, Follicular 45 10 41
Follicular Thyroid Carcinoma 9 41 60
Thyroid Follicular Carcinoma 43 22
Thyroid Cancer, Follicular 41 60
Follicular Adenocarcinoma, Well Differentiated 9
Follicular Carcinoma of the Thyroid Gland 9
Thyroid Carcinoma, Follicular, Somatic 45
 
Thyroid Gland Adenocarcinoma 60
Follicular Adenocarcinoma 9
Follicular Thyroid Cancer 43
Thyroid Adenocarcinoma 9
Follicular Carcinoma 9
Ftc 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


External Ids:

OMIM45 188470
Disease Ontology9 DOID:3962
NCIt38 C8054
MeSH33 D018263

Related Diseases for Thyroid Carcinoma, Follicular

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Diseases related to Thyroid Carcinoma, Follicular via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1neuroblastoma30.8AKT1
2goiter30.7RET, BRAF
3pancreatitis30.5HRAS, NRAS, KRAS
4papillary carcinoma30.4HRAS, BRAF, RET
5adenomatous polyposis coli30.1NRAS, KRAS, BRAF
6thyroid carcinoma, papillary30.0PTEN, BRAF, HRAS, RET
7sarcoma30.0BRAF, HRAS, KRAS, NRAS
8medullary thyroid carcinoma, familial29.9RET, BRAF
9follicular adenoma29.8BRAF, PTEN, HRAS, RET
10adenoma29.8BRAF, KRAS, RET, HRAS, NRAS
11thyroid adenoma29.7PIK3CA, RET, BRAF, PTEN
12thyroid cancer29.5PIK3CA, RET, HRAS, PTEN, BRAF
13adenocarcinoma29.3AKT1, HRAS, KRAS, PIK3CA, PTEN, BRAF
14thyroiditis10.8
15leopard syndrome10.5HRAS
16hyperthyroidism10.5
17cowden syndrome 110.5PTEN
18pilocytic astrocytoma10.5PTEN
19mediastinitis10.5
20proteus syndrome, somatic10.5PTEN
21lipomatosis10.4PTEN
22multinodular goiter10.4
23cervicitis10.4
24thyrotoxicosis10.4
25familial papillary or follicular thyroid carcinoma10.4
26choroiditis10.3
27graves' disease10.3
28back pain10.3
29endotheliitis10.3
30bone marrow cancer10.3NRAS, KRAS
31thyroid carcinoma, hurthle cell10.3
32bannayan-riley-ruvalcaba syndrome10.3MINPP1, PTEN
33papillary follicular thyroid adenocarcinoma10.2
34large cell carcinoma10.2HRAS, KRAS
35gastric cancer, somatic10.2KRAS, PIK3CA
36exanthem10.2HRAS, KRAS, NRAS
37leukemia, juvenile myelomonocytic10.2HRAS, NRAS, KRAS
38gallbladder cancer10.2KRAS, NRAS, HRAS
39pleuropulmonary blastoma10.2
40hematopoietic stem cell transplantation10.2
41myasthenia gravis10.2
42sinusitis10.2
43subacute thyroiditis10.2
44olfactory neuroblastoma10.2
45blastoma10.2
46thrombocytosis10.2
47acromegaly10.2
48situs inversus10.2
49primary hyperparathyroidism10.2
50down syndrome10.2

Graphical network of the top 20 diseases related to Thyroid Carcinoma, Follicular:



Diseases related to thyroid carcinoma, follicular

Symptoms for Thyroid Carcinoma, Follicular

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Symptoms by clinical synopsis from OMIM:

188470

Clinical features from OMIM:

188470

HPO human phenotypes related to Thyroid Carcinoma, Follicular:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of metabolism/homeostasis HP:0001939
3 follicular thyroid carcinoma HP:0006731

Drugs & Therapeutics for Thyroid Carcinoma, Follicular

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Drug clinical trials:

Search ClinicalTrials for Thyroid Carcinoma, Follicular

Search NIH Clinical Center for Thyroid Carcinoma, Follicular

Genetic Tests for Thyroid Carcinoma, Follicular

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Genetic tests related to Thyroid Carcinoma, Follicular:

id Genetic test Affiliating Genes
1 Thyroid Cancer, Follicular22

Anatomical Context for Thyroid Carcinoma, Follicular

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MalaCards organs/tissues related to Thyroid Carcinoma, Follicular:

31
Thyroid, Bone, Lymph node, Lung

Animal Models for Thyroid Carcinoma, Follicular or affiliated genes

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MGI Mouse Phenotypes related to Thyroid Carcinoma, Follicular:

35 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.4KRAS, NRAS, RET, PTEN
2MP:00053708.4PTEN, BRAF, AKT1, NRAS, KRAS
3MP:00053758.2PIK3CA, PTEN, BRAF, AKT1
4MP:00053918.1PIK3CA, PTEN, BRAF, NRAS, KRAS
5MP:00053678.0PTEN, BRAF, RET, KRAS, HRAS
6MP:00053818.0KRAS, NRAS, RET, BRAF, PTEN
7MP:00053887.7PTEN, BRAF, AKT1, RET, KRAS, HRAS
8MP:00107717.6PIK3CA, PTEN, BRAF, AKT1, NRAS, KRAS
9MP:00053697.4PIK3CA, PTEN, BRAF, AKT1, RET, KRAS
10MP:00053977.3PTEN, BRAF, AKT1, RET, NRAS, KRAS
11MP:00053897.3PIK3CA, PTEN, BRAF, AKT1, RET, KRAS
12MP:00053807.1PIK3CA, PTEN, BRAF, AKT1, RET, NRAS
13MP:00053797.1PIK3CA, PTEN, BRAF, AKT1, RET, KRAS
14MP:00028737.1PTEN, BRAF, AKT1, RET, MINPP1, NRAS
15MP:00053877.0PIK3CA, PTEN, BRAF, AKT1, RET, NRAS
16MP:00053867.0PIK3CA, PTEN, BRAF, AKT1, RET, KRAS
17MP:00053847.0PIK3CA, PTEN, BRAF, AKT1, RET, NRAS
18MP:00036317.0PIK3CA, PTEN, BRAF, AKT1, RET, KRAS
19MP:00020066.8HRAS, PIK3CA, PTEN, BRAF, AKT1, RET
20MP:00053856.8PIK3CA, PTEN, BRAF, AKT1, RET, NRAS
21MP:00053786.8PIK3CA, PTEN, BRAF, AKT1, RET, NRAS
22MP:00053766.8PIK3CA, PTEN, BRAF, AKT1, RET, NRAS
23MP:00107686.7PIK3CA, PTEN, BRAF, AKT1, RET, NRAS

Publications for Thyroid Carcinoma, Follicular

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Articles related to Thyroid Carcinoma, Follicular:

idTitleAuthorsYear
1
Comparison of proliferating cell nuclear antigen, thyroid transcription factor-1, Ki-67, p63, p53 and high-molecular weight cytokeratin expressions in papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. (21315633)
2011
2
Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. (20526288)
2010
3
Hyperfunctioning thyroid adenoma concomitant with papillary thyroid carcinoma, follicular thyroid adenoma and primary hyperparathyroidism. (9625447)
1998

Variations for Thyroid Carcinoma, Follicular

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Clinvar genetic disease variations for Thyroid Carcinoma, Follicular:

6
id Gene Variation Type Significance SNP ID Assembly Location
1HRASNM_005343.2(HRAS): c.181C> A (p.Gln61Lys)single nucleotide variantPathogenicrs28933406GRCh37Chr 11, 533875: 533875
2NRASNM_002524.4(NRAS): c.182A> G (p.Gln61Arg)single nucleotide variantPathogenicrs11554290GRCh37Chr 1, 115256529: 115256529
3BRAFNM_004333.4(BRAF): c.1801A> G (p.Lys601Glu)single nucleotide variantPathogenicrs121913364GRCh37Chr 7, 140453134: 140453134
4MINPP1NM_004897.4(MINPP1): c.122C> T (p.Ser41Leu)single nucleotide variantPathogenicrs119486096GRCh37Chr 10, 89264794: 89264794
5MINPP1NM_004897.4(MINPP1): c.809A> G (p.Gln270Arg)single nucleotide variantPathogenicrs104894171GRCh37Chr 10, 89268264: 89268264

Cosmic variations for Thyroid Carcinoma, Follicular:

7 (show all 128)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1778PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
21666844PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
3760PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
433600PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
529110PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
617446PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
729097PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
833601PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
929329PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
1029106PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
1112597PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
12759PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
1329108PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
14775PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
1533599PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
1629096PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
1728544PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
1827133PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
1917443PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
2012458PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
2133598PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
22763PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
2329095PIK3CAthyroid,NS,carcinoma,follicular carcinoma3
24527KRASthyroid,NS,carcinoma,papillary carcinoma3
25522KRASthyroid,NS,carcinoma,follicular carcinoma3
26518KRASthyroid,NS,carcinoma,follicular carcinoma3
27528KRASthyroid,NS,carcinoma,papillary carcinoma3
2826146KRASthyroid,NS,carcinoma,papillary carcinoma3
29548KRASthyroid,NS,carcinoma,papillary carcinoma3
30529KRASthyroid,NS,carcinoma,papillary carcinoma3
31551KRASthyroid,NS,carcinoma,follicular carcinoma3
32552KRASthyroid,NS,carcinoma,follicular carcinoma3
33521KRASthyroid,NS,carcinoma,papillary carcinoma3
34517KRASthyroid,NS,carcinoma,papillary carcinoma3
35533KRASthyroid,NS,carcinoma,papillary carcinoma3
36516KRASthyroid,NS,carcinoma,papillary carcinoma3
37520KRASthyroid,NS,carcinoma,papillary carcinoma3
38549KRASthyroid,NS,carcinoma,papillary carcinoma3
39532KRASthyroid,NS,carcinoma,follicular carcinoma3
40485HRASthyroid,NS,carcinoma,papillary carcinoma3
41486HRASthyroid,NS,carcinoma,papillary carcinoma3
42490HRASthyroid,NS,carcinoma,papillary carcinoma3
433736923HRASthyroid,NS,carcinoma,follicular carcinoma3
44500HRASthyroid,NS,carcinoma,follicular carcinoma3
45480HRASthyroid,NS,carcinoma,papillary carcinoma3
46488HRASthyroid,NS,carcinoma,papillary carcinoma3
47110720HRASthyroid,NS,carcinoma,papillary carcinoma3
48481HRASthyroid,NS,carcinoma,papillary carcinoma3
49483HRASthyroid,NS,carcinoma,papillary carcinoma3
50482HRASthyroid,NS,carcinoma,papillary carcinoma3
51484HRASthyroid,NS,carcinoma,papillary carcinoma3
52496HRASthyroid,NS,carcinoma,papillary carcinoma3
53503HRASthyroid,NS,carcinoma,follicular carcinoma3
54498HRASthyroid,NS,carcinoma,follicular carcinoma3
55499HRASthyroid,NS,carcinoma,follicular carcinoma3
56564NRASthyroid,NS,carcinoma,papillary carcinoma3
57586NRASthyroid,NS,carcinoma,papillary carcinoma3
58585NRASthyroid,NS,carcinoma,papillary carcinoma3
59579NRASthyroid,NS,carcinoma,follicular carcinoma3
60573NRASthyroid,NS,carcinoma,papillary carcinoma3
61570NRASthyroid,NS,carcinoma,papillary carcinoma3
62562NRASthyroid,NS,carcinoma,papillary carcinoma3
63583NRASthyroid,NS,carcinoma,papillary carcinoma3
64584NRASthyroid,NS,carcinoma,follicular carcinoma3
65580NRASthyroid,NS,carcinoma,follicular carcinoma3
6628049NRASthyroid,NS,carcinoma,follicular carcinoma3
6728048NRASthyroid,NS,carcinoma,papillary carcinoma3
6810834TP53thyroid,NS,carcinoma,papillary carcinoma3
6943624TP53thyroid,NS,carcinoma,follicular carcinoma3
70144150TP53thyroid,NS,carcinoma,follicular carcinoma3
7143981TP53thyroid,NS,carcinoma,papillary carcinoma3
7243980TP53thyroid,NS,carcinoma,papillary carcinoma3
7310739TP53thyroid,NS,carcinoma,papillary carcinoma3
7443979TP53thyroid,NS,carcinoma,papillary carcinoma3
7510656TP53thyroid,NS,carcinoma,follicular carcinoma3
7610771TP53thyroid,NS,carcinoma,papillary carcinoma3
7710704TP53thyroid,NS,carcinoma,papillary carcinoma3
7810867TP53thyroid,NS,carcinoma,papillary carcinoma3
7910863TP53thyroid,NS,carcinoma,papillary carcinoma3
8023653PTENthyroid,NS,carcinoma,follicular carcinoma3
8123654PTENthyroid,NS,carcinoma,follicular carcinoma3
8223652PTENthyroid,NS,carcinoma,follicular carcinoma3
8323649PTENthyroid,NS,carcinoma,follicular carcinoma3
845224PTENthyroid,NS,carcinoma,follicular carcinoma3
8523650PTENthyroid,NS,carcinoma,follicular carcinoma3
865092PTENthyroid,NS,carcinoma,papillary carcinoma3
8723651PTENthyroid,NS,carcinoma,follicular carcinoma3
885033PTENthyroid,NS,carcinoma,follicular carcinoma3
895034PTENthyroid,NS,carcinoma,follicular carcinoma3
905759CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
915760CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
925662CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
935706CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
945762CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
955707CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
965761CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
975723CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
9821549BRAFthyroid,NS,carcinoma,papillary carcinoma3
9930671BRAFthyroid,NS,carcinoma,papillary carcinoma3
1001131BRAFthyroid,NS,carcinoma,papillary carcinoma3
10113982BRAFthyroid,NS,carcinoma,papillary carcinoma3
102476BRAFthyroid,NS,carcinoma,papillary carcinoma3
103478BRAFthyroid,NS,carcinoma,papillary carcinoma3
104475BRAFthyroid,NS,carcinoma,papillary carcinoma3
10596532IDH1thyroid,NS,carcinoma,follicular carcinoma3
10696531IDH1thyroid,NS,carcinoma,papillary carcinoma3
10796534IDH1thyroid,NS,carcinoma,papillary carcinoma3
10896533IDH1thyroid,NS,carcinoma,follicular carcinoma3
10997131IDH1thyroid,NS,carcinoma,papillary carcinoma3
11096923IDH1thyroid,NS,carcinoma,papillary carcinoma3
11114193SMAD4thyroid,NS,carcinoma,papillary carcinoma3
11214196SMAD4thyroid,NS,carcinoma,papillary carcinoma3
11314189SMAD4thyroid,NS,carcinoma,papillary carcinoma3
11414186SMAD4thyroid,NS,carcinoma,papillary carcinoma3
11514185SMAD4thyroid,NS,carcinoma,papillary carcinoma3
11620897EGFRthyroid,NS,carcinoma,papillary carcinoma3
11720896EGFRthyroid,NS,carcinoma,papillary carcinoma3
11813182EGFRthyroid,NS,carcinoma,papillary carcinoma3
1196224EGFRthyroid,NS,carcinoma,papillary carcinoma3
12029274EGFRthyroid,NS,carcinoma,papillary carcinoma3
12127899GNASthyroid,NS,carcinoma,papillary carcinoma3
12227887GNASthyroid,NS,carcinoma,papillary carcinoma3
12313224CDKN2Athyroid,NS,carcinoma,follicular carcinoma3
12413292CDKN2Athyroid,NS,carcinoma,papillary carcinoma3
12533765AKT1thyroid,NS,carcinoma,papillary carcinoma3
126786FLT3thyroid,NS,carcinoma,papillary carcinoma3
127707METthyroid,NS,carcinoma,follicular carcinoma3
12817721VHLthyroid,NS,carcinoma,papillary carcinoma3

Expression for genes affiliated with Thyroid Carcinoma, Follicular

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Search GEO for disease gene expression data for Thyroid Carcinoma, Follicular.

Pathways for genes affiliated with Thyroid Carcinoma, Follicular

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Pathways related to Thyroid Carcinoma, Follicular according to GeneCards Suite gene sharing:

(show top 50)    (show all 165)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.8HRAS, KRAS, NRAS, BRAF
2
Show member pathways
8.8HRAS, KRAS, NRAS, BRAF
3
Show member pathways
8.7PIK3CA, HRAS, KRAS, NRAS
48.6PTEN, AKT1, HRAS, PIK3CA
58.5AKT1, BRAF, HRAS, PIK3CA
68.5AKT1, BRAF, PIK3CA, HRAS
78.4PTEN, BRAF, HRAS, NRAS, AKT1
8
Show member pathways
8.4HRAS, AKT1, NRAS, KRAS, PTEN
98.4KRAS, AKT1, HRAS, NRAS, PTEN
10
Show member pathways
8.3BRAF, AKT1, KRAS, HRAS, NRAS
11
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells58
Oncostatin M Signaling Pathway36
8.3KRAS, NRAS, AKT1, BRAF, HRAS
12
Show member pathways
8.2HRAS, PIK3CA, BRAF, NRAS, KRAS
13
Show member pathways
8.2KRAS, HRAS, NRAS, PIK3CA, BRAF
14
Show member pathways
8.2KRAS, NRAS, HRAS, PIK3CA, BRAF
15
Show member pathways
Immune response CD16 signaling in NK cells58
8.2NRAS, HRAS, PIK3CA, KRAS, BRAF
16
Show member pathways
8.1HRAS, AKT1, PIK3CA, KRAS, NRAS
178.1KRAS, AKT1, PIK3CA, HRAS, NRAS
188.1HRAS, KRAS, AKT1, NRAS, PIK3CA
19
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
8.1KRAS, NRAS, AKT1, HRAS, PIK3CA
20
Show member pathways
8.1KRAS, AKT1, HRAS, PIK3CA, NRAS
218.0HRAS, KRAS, NRAS, RET, BRAF
22
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
7.8PTEN, HRAS, NRAS, AKT1, BRAF, PIK3CA
23
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
7.7AKT1, NRAS, KRAS, HRAS, PTEN, PIK3CA
24
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
7.7AKT1, PTEN, PIK3CA, HRAS, KRAS, NRAS
25
Show member pathways
7.7HRAS, KRAS, NRAS, AKT1, PTEN, PIK3CA
267.7PTEN, HRAS, AKT1, KRAS, PIK3CA, NRAS
27
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
7.7PIK3CA, KRAS, PTEN, AKT1, HRAS, NRAS
28
Show member pathways
7.7KRAS, PIK3CA, PTEN, NRAS, HRAS, AKT1
29
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
7.7AKT1, PIK3CA, NRAS, HRAS, BRAF, KRAS
30
Show member pathways
Development EDNRB signaling58
Development ACM2 and ACM4 activation of ERK58
Cell adhesion Integrin inside out signaling58
Development G Proteins mediated regulation MARK ERK signaling58
Signal transduction IP3 signaling58
Development Angiotensin signaling via PYK258
Development EPO induced MAPK pathway58
7.7AKT1, BRAF, PIK3CA, NRAS, KRAS, HRAS
31
Show member pathways
7.7NRAS, BRAF, KRAS, HRAS, AKT1, PIK3CA
32
Show member pathways
7.7PIK3CA, BRAF, AKT1, KRAS, HRAS, NRAS
33
Show member pathways
7.7NRAS, HRAS, PIK3CA, BRAF, AKT1, KRAS
347.7PIK3CA, BRAF, AKT1, NRAS, KRAS, HRAS
35
Show member pathways
7.7KRAS, NRAS, PIK3CA, AKT1, BRAF, HRAS
367.7PIK3CA, BRAF, AKT1, NRAS, KRAS, HRAS
377.7PIK3CA, HRAS, KRAS, NRAS, AKT1, BRAF
38
Show member pathways
7.7PIK3CA, HRAS, KRAS, NRAS, AKT1, BRAF
39
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
7.6PTEN, BRAF, HRAS, AKT1, KRAS, PIK3CA
40
Show member pathways
Development ERBB family signaling58
Development GDNF family signaling58
7.4BRAF, AKT1, NRAS, RET, HRAS, PIK3CA
41
Show member pathways
Signal transduction PTEN pathway58
7.3KRAS, NRAS, AKT1, BRAF, PTEN, PIK3CA
42
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
7.3BRAF, HRAS, KRAS, NRAS, AKT1, PTEN
43
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
7.3PIK3CA, AKT1, BRAF, NRAS, KRAS, HRAS
44
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
7.3NRAS, KRAS, PIK3CA, PTEN, BRAF, AKT1
457.3HRAS, KRAS, NRAS, AKT1, BRAF, PIK3CA
46
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
7.3PIK3CA, BRAF, AKT1, NRAS, KRAS, HRAS
47
Show member pathways
7.3PIK3CA, HRAS, BRAF, KRAS, NRAS, PTEN
48
Show member pathways
Signaling Pathways in Glioblastoma36
7.3PIK3CA, KRAS, HRAS, NRAS, AKT1, BRAF
49
Show member pathways
6.9BRAF, HRAS, KRAS, NRAS, RET, AKT1
506.5KRAS, HRAS, RET, AKT1, BRAF, PTEN

Compounds for genes affiliated with Thyroid Carcinoma, Follicular

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Compounds related to Thyroid Carcinoma, Follicular according to GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1panitumumab43 49 1211.5PTEN, KRAS, BRAF
2gemcitabine43 49 1211.5AKT1, PTEN, HRAS
3farnesyl diphosphate43 28 1211.4HRAS, AKT1, KRAS
4cetuximab43 49 1211.4KRAS, BRAF, PTEN
5sodium iodide439.4RET, BRAF
6ptdins(3)p439.3PIK3CA, AKT1
7erlotinib43 49 1211.2PTEN, KRAS, PIK3CA
8phosphatidylinositol-3,4,5-trisphosphate43 2410.1PTEN, AKT1, PIK3CA
9quercetin43 59 24 1212.0AKT1, PTEN, PIK3CA
10regorafenib49 1210.0RET, KRAS, BRAF
11herbimycin a43 599.9AKT1, RET, HRAS
12inositol438.9MINPP1, AKT1, PTEN, PIK3CA
13doxorubicin43 49 1210.9AKT1, HRAS, PIK3CA, PTEN
14arsenite43 249.8PTEN, PIK3CA, AKT1
15gefitinib43 49 1210.8PTEN, PIK3CA, KRAS, AKT1
16progesterone43 28 59 24 1212.7HRAS, BRAF, PTEN, PIK3CA
17cyclic amp43 249.6PTEN, BRAF, HRAS, RET
18ceramide438.6PIK3CA, AKT1, PTEN
19phosphotyrosine438.6HRAS, PTEN, RET, PIK3CA
20crcs438.6KRAS, BRAF, PTEN, PIK3CA, HRAS
21leucine438.5RET, PIK3CA, PTEN, HRAS
22glucose438.4AKT1, HRAS, BRAF, PTEN, PIK3CA
23h2o2438.4PIK3CA, HRAS, KRAS, AKT1, PTEN
24gtp43 289.4KRAS, BRAF, PIK3CA, AKT1, HRAS
25aspartate438.3RET, HRAS, AKT1, PTEN, BRAF
26valine438.2BRAF, AKT1, RET, HRAS, KRAS
27genistein43 28 59 2 24 1213.1HRAS, RET, PTEN, AKT1, PIK3CA
28atp43 289.1HRAS, RET, BRAF, PTEN, PIK3CA
29testosterone43 59 24 1211.1PTEN, AKT1, RET, PIK3CA
30imatinib43 49 1210.1PIK3CA, PTEN, BRAF, RET, KRAS
31paclitaxel43 49 1210.0BRAF, HRAS, KRAS, AKT1, PTEN, PIK3CA
32rapamycin438.0AKT1, PIK3CA, BRAF, KRAS, HRAS, PTEN
33phosphoinositide438.0AKT1, KRAS, BRAF, PTEN, HRAS, PIK3CA
34cisplatin43 49 59 1211.0HRAS, AKT1, PTEN, PIK3CA, BRAF, KRAS
35oligonucleotide438.0KRAS, HRAS, PTEN, NRAS, BRAF, RET
36estrogen438.0PIK3CA, PTEN, AKT1, BRAF, KRAS, HRAS
37adp43 28 249.9PIK3CA, RET, PTEN, BRAF, AKT1
38paraffin437.8BRAF, KRAS, RET, AKT1, PTEN, HRAS
39pd 98,059437.7HRAS, RET, AKT1, PTEN, PIK3CA, BRAF
40arginine437.7PIK3CA, HRAS, RET, BRAF, AKT1, PTEN
41threonine437.7BRAF, AKT1, RET, HRAS, PTEN, PIK3CA
42agar437.4PTEN, HRAS, RET, NRAS, AKT1, BRAF
43ly294002437.2BRAF, PTEN, PIK3CA, HRAS, AKT1, RET
44wortmannin437.2RET, AKT1, PIK3CA, BRAF, HRAS, KRAS
45vegf437.2KRAS, RET, AKT1, BRAF, HRAS, PTEN
46phosphatidylinositol437.2RET, KRAS, AKT1, PIK3CA, PTEN, BRAF
47retinoic acid43 248.2PIK3CA, BRAF, AKT1, RET, KRAS, HRAS
48lipid437.2HRAS, KRAS, PIK3CA, PTEN, BRAF, AKT1
49serine437.2KRAS, RET, AKT1, BRAF, PTEN, PIK3CA
50tyrosine436.9PTEN, HRAS, PIK3CA, NRAS, KRAS, RET

GO Terms for genes affiliated with Thyroid Carcinoma, Follicular

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Cellular components related to Thyroid Carcinoma, Follicular according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058867.3HRAS, KRAS, NRAS, AKT1, BRAF, PTEN

Biological processes related to Thyroid Carcinoma, Follicular according to GeneCards Suite gene sharing:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell sizeGO:00457929.8PTEN, AKT1
2regulation of neuron projection developmentGO:00109759.8PTEN, AKT1
3inositol phosphate metabolic processGO:00436479.7MINPP1, PTEN
4positive regulation of Rac protein signal transductionGO:00350229.7NRAS, KRAS, HRAS
5regulation of synaptic transmission, GABAergicGO:00322289.7NRAS, KRAS, HRAS
6regulation of long-term neuronal synaptic plasticityGO:00481699.6NRAS, KRAS, HRAS
7visual learningGO:00085429.6NRAS, KRAS, HRAS
8positive regulation of nitric-oxide synthase activityGO:00510009.6AKT1, KRAS
9Ras protein signal transductionGO:00072659.6HRAS, KRAS, NRAS
10endothelial cell migrationGO:00435429.6PTEN, PIK3CA
11GTP catabolic processGO:00061849.5HRAS, KRAS, NRAS
12social behaviorGO:00351769.5HRAS, KRAS, PTEN
13actin cytoskeleton organizationGO:00300369.5HRAS, KRAS, NRAS
14positive regulation of protein phosphorylationGO:00019349.4AKT1, KRAS, HRAS
15axon guidanceGO:00074119.4NRAS, KRAS, HRAS
16positive regulation of MAP kinase activityGO:00434069.3KRAS, HRAS
17protein kinase B signalingGO:00434919.3PIK3CA, PTEN, AKT1
18activation of MAPKK activityGO:00001869.2HRAS, KRAS, NRAS, BRAF
19cell proliferationGO:00082839.2HRAS, AKT1, PTEN
20positive regulation of peptidyl-serine phosphorylationGO:00331389.2AKT1, BRAF, PIK3CA
21striated muscle cell differentiationGO:00511469.2HRAS, KRAS, NRAS, AKT1
22positive regulation of cell proliferationGO:00082849.2PTEN, NRAS, KRAS, HRAS
23small GTPase mediated signal transductionGO:00072649.1BRAF, NRAS, KRAS, HRAS
24phosphatidylinositol-mediated signalingGO:00480159.1AKT1, PTEN, PIK3CA
25leukocyte migrationGO:00509009.0HRAS, KRAS, NRAS, PIK3CA
26MAPK cascadeGO:00001658.8RET, NRAS, KRAS, HRAS
27negative regulation of neuron apoptotic processGO:00435248.6PIK3CA, BRAF, NRAS, KRAS, HRAS
28protein phosphorylationGO:00064688.6BRAF, AKT1, RET
29insulin receptor signaling pathwayGO:00082868.5HRAS, KRAS, NRAS, AKT1, PIK3CA
30blood coagulationGO:00075968.5HRAS, KRAS, NRAS, AKT1, PIK3CA
31Fc-epsilon receptor signaling pathwayGO:00380958.1PIK3CA, PTEN, AKT1, NRAS, KRAS, HRAS
32epidermal growth factor receptor signaling pathwayGO:00071738.1PIK3CA, PTEN, AKT1, NRAS, KRAS, HRAS
33innate immune responseGO:00450878.1HRAS, KRAS, NRAS, AKT1, PTEN, PIK3CA
34fibroblast growth factor receptor signaling pathwayGO:00085437.7HRAS, PIK3CA, PTEN, BRAF, AKT1, NRAS
35neurotrophin TRK receptor signaling pathwayGO:00480117.7PIK3CA, PTEN, BRAF, AKT1, NRAS, KRAS

Molecular functions related to Thyroid Carcinoma, Follicular according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:00163019.0AKT1, PIK3CA
2protein serine/threonine kinase activityGO:00046748.9AKT1, BRAF, PIK3CA
3protein bindingGO:00055156.7HRAS, PIK3CA, PTEN, BRAF, AKT1, RET

Products for genes affiliated with Thyroid Carcinoma, Follicular

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Thyroid Carcinoma, Follicular

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet