MCID: THY059
MIFTS: 34

Thyroid Carcinoma, Follicular, Somatic malady

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Summaries for Thyroid Carcinoma, Follicular, Somatic

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MalaCards based summary: Thyroid Carcinoma, Follicular, Somatic is related to leopard syndrome and cardiofaciocutaneous syndrome, and has symptoms including An important gene associated with Thyroid Carcinoma, Follicular, Somatic is HRAS (Harvey rat sarcoma viral oncogene homolog), and among its related pathways are Bisphosphonate Pathway, Pharmacodynamics and EGFR Transactivation by Gastrin. The compounds panitumumab and cetuximab have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and lymph node, and related mouse phenotypes are craniofacial and tumorigenesis.

Description from OMIM:46 188470

Aliases & Classifications for Thyroid Carcinoma, Follicular, Somatic

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Thyroid Carcinoma, Follicular, Somatic, Aliases & Descriptions:

Name: Thyroid Carcinoma, Follicular, Somatic 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Related Diseases for Thyroid Carcinoma, Follicular, Somatic

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Diseases related to Thyroid Carcinoma, Follicular, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1leopard syndrome10.4HRAS
2cardiofaciocutaneous syndrome10.4BRAF
3pilocytic astrocytoma10.3PTEN
4spitz nevus10.2HRAS, BRAF
5costello syndrome10.2BRAF, HRAS
6exanthem10.2NRAS, HRAS
7juvenile myelomonocytic leukemia10.2HRAS, NRAS
8nodular goiter10.2HRAS, BRAF
9gallbladder cancer10.2HRAS, NRAS
10skin benign neoplasm10.2BRAF, HRAS
11lynch syndrome10.2BRAF, NRAS
12congenital heart disease10.2BRAF, HRAS
13oligodendroglioma10.1PTEN, BRAF
14developmental disabilities10.1HRAS, BRAF
15uveal melanoma10.1BRAF, NRAS
16follicular thyroid carcinoma10.1BRAF, PTEN
17papillary thyroid carcinoma10.1BRAF, PTEN
18papillary carcinoma10.1BRAF, HRAS
19thyroid adenoma10.1PTEN, BRAF
20endometrial carcinoma10.1BRAF, PTEN
21thyroid cancer, anaplastic10.1BRAF, PTEN
22cholangiocarcinoma10.1NRAS, BRAF
23short stature10.1HRAS, BRAF
24pancreatitis10.0NRAS, HRAS
25non-small cell lung carcinoma10.0HRAS, BRAF
26bannayan-riley-ruvalcaba syndrome10.0PTEN, MINPP1
27noonan syndrome10.0BRAF, NRAS, HRAS
28sarcoma10.0HRAS, NRAS, BRAF
29familial adenomatous polyposis10.0BRAF, NRAS
30lung cancer10.0NRAS, PTEN, HRAS
31follicular adenoma10.0BRAF, HRAS, PTEN
32thyroid hurthle cell carcinoma10.0PTEN, BRAF, HRAS
33pancreatic cancer9.9BRAF, HRAS, NRAS
34colorectal cancer9.9PTEN, HRAS, BRAF
35adenoma9.9HRAS, BRAF, NRAS
36malignant glioma9.9BRAF, PTEN, HRAS
37colonic benign neoplasm9.8PTEN, BRAF, HRAS
38ovarian cancer9.7HRAS, BRAF, NRAS, PTEN
39melanoma9.7HRAS, PTEN, BRAF, NRAS
40breast cancer9.7NRAS, PTEN, BRAF, HRAS
41adenocarcinoma9.6PTEN, BRAF, HRAS

Graphical network of the top 20 diseases related to Thyroid Carcinoma, Follicular, Somatic:



Diseases related to thyroid carcinoma, follicular, somatic

Symptoms for Thyroid Carcinoma, Follicular, Somatic

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Symptoms by clinical synopsis from OMIM:

188470

Clinical features from OMIM:

188470

HPO human phenotypes related to Thyroid Carcinoma, Follicular, Somatic:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of metabolism/homeostasis HP:0001939
3 follicular thyroid carcinoma HP:0006731

Drugs & Therapeutics for Thyroid Carcinoma, Follicular, Somatic

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Drug clinical trials:

Search ClinicalTrials for Thyroid Carcinoma, Follicular, Somatic

Search NIH Clinical Center for Thyroid Carcinoma, Follicular, Somatic

Genetic Tests for Thyroid Carcinoma, Follicular, Somatic

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Anatomical Context for Thyroid Carcinoma, Follicular, Somatic

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MalaCards organs/tissues related to Thyroid Carcinoma, Follicular, Somatic:

32
Thyroid, Bone, Lymph node, Lung

Animal Models for Thyroid Carcinoma, Follicular, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Thyroid Carcinoma, Follicular, Somatic:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9HRAS, BRAF, PTEN
2MP:00020068.4PTEN, BRAF, NRAS, HRAS
3MP:00107718.3PTEN, BRAF, NRAS, HRAS
4MP:00053858.1HRAS, NRAS, BRAF, PTEN
5MP:00028737.6HRAS, NRAS, MINPP1, BRAF, PTEN

Publications for Thyroid Carcinoma, Follicular, Somatic

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Variations for Thyroid Carcinoma, Follicular, Somatic

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Clinvar genetic disease variations for Thyroid Carcinoma, Follicular, Somatic:

6
id Gene Name Type Significance SNP ID Assembly Location
1HRASNM_005343.2(HRAS): c.181C> A (p.Gln61Lys)single nucleotide variantPathogenicrs28933406GRCh37Chr 11, 533875: 533875
2NRASNM_002524.4(NRAS): c.182A> G (p.Gln61Arg)single nucleotide variantPathogenicrs11554290GRCh37Chr 1, 115256529: 115256529
3BRAFNM_004333.4(BRAF): c.1801A> G (p.Lys601Glu)single nucleotide variantPathogenicrs121913364GRCh37Chr 7, 140453134: 140453134
4MINPP1NM_004897.4(MINPP1): c.122C> T (p.Ser41Leu)single nucleotide variantPathogenicrs119486096GRCh37Chr 10, 89264794: 89264794
5MINPP1NM_004897.4(MINPP1): c.809A> G (p.Gln270Arg)single nucleotide variantPathogenicrs104894171GRCh37Chr 10, 89268264: 89268264

Expression for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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Expression patterns in normal tissues for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

Search GEO for disease gene expression data for Thyroid Carcinoma, Follicular, Somatic.

Pathways for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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Pathways related to Thyroid Carcinoma, Follicular, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NRAS, HRAS
2
Show member pathways
EGFR-dependent Endothelin signaling events37
9.5HRAS, NRAS
3
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.0BRAF, HRAS, NRAS
49.0HRAS, NRAS, BRAF
5
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.0HRAS, NRAS, BRAF
6
Show member pathways
9.0BRAF, NRAS, HRAS
7
Show member pathways
9.0BRAF, HRAS, NRAS
8
Show member pathways
9.0BRAF, HRAS, NRAS
9
Show member pathways
9.0HRAS, NRAS, BRAF
10
Show member pathways
9.0HRAS, NRAS, BRAF
11
Show member pathways
9.0BRAF, HRAS, NRAS
12
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.0HRAS, NRAS, BRAF
139.0HRAS, NRAS, BRAF
14
Show member pathways
9.0NRAS, BRAF, HRAS
15
Show member pathways
Immune response CD16 signaling in NK cells60
9.0HRAS, BRAF, NRAS
16
Show member pathways
9.0BRAF, NRAS, HRAS
17
Show member pathways
9.0HRAS, NRAS, BRAF
18
Show member pathways
9.0HRAS, BRAF, NRAS
19
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
9.0HRAS, NRAS, BRAF
209.0NRAS, BRAF, HRAS
21
Show member pathways
9.0BRAF, NRAS, HRAS
229.0HRAS, NRAS, BRAF
23
Show member pathways
9.0NRAS, HRAS, BRAF
249.0BRAF, NRAS, HRAS
25
Show member pathways
9.0NRAS, BRAF, HRAS
26
Show member pathways
8.9HRAS, NRAS, PTEN
27
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.9HRAS, NRAS, PTEN
28
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.9HRAS, NRAS, PTEN
29
Show member pathways
8.9PTEN, NRAS, HRAS
308.9PTEN, NRAS, HRAS
31
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.9PTEN, NRAS, HRAS
32
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.9BRAF, PTEN, HRAS
338.9BRAF, PTEN, HRAS
34
Show member pathways
Signal transduction PTEN pathway60
8.4HRAS, PTEN, BRAF, NRAS
35
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
8.4PTEN, NRAS, BRAF, HRAS
36
Show member pathways
Signaling Pathways in Glioblastoma37
8.4HRAS, NRAS, BRAF, PTEN
37
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.4NRAS, BRAF, PTEN, HRAS
38
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
8.4HRAS, BRAF, NRAS, PTEN
39
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.4HRAS, NRAS, PTEN, BRAF
40
Show member pathways
8.4HRAS, BRAF, PTEN, NRAS
41
Show member pathways
8.4BRAF, NRAS, PTEN, HRAS
42
Show member pathways
8.4NRAS, BRAF, PTEN, HRAS
43
Show member pathways
8.4NRAS, BRAF, HRAS, PTEN
44
Show member pathways
8.4PTEN, HRAS, NRAS, BRAF
458.4PTEN, NRAS, BRAF, HRAS
46
Show member pathways
8.4PTEN, HRAS, NRAS, BRAF
47
Show member pathways
8.4NRAS, BRAF, HRAS, PTEN
48
Show member pathways
8.4PTEN, BRAF, NRAS, HRAS
498.4PTEN, BRAF, NRAS, HRAS
50
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.4PTEN, BRAF, NRAS, HRAS

Compounds for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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Compounds related to Thyroid Carcinoma, Follicular, Somatic according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1panitumumab44 50 1111.7BRAF, PTEN
2cetuximab44 50 1111.6BRAF, PTEN
3gemcitabine44 50 1111.6PTEN, HRAS
4lovastatin44 50 61 28 1113.5HRAS, PTEN
5crcs449.3PTEN, BRAF, HRAS
6paclitaxel44 50 1111.2HRAS, BRAF, PTEN
7rapamycin449.2HRAS, BRAF, PTEN
8pd 98,059449.2PTEN, BRAF, HRAS
9ly294002449.2HRAS, BRAF, PTEN
10wortmannin449.2PTEN, BRAF, HRAS
11phosphoinositide449.2HRAS, BRAF, PTEN
12paraffin449.2PTEN, BRAF, HRAS
13cisplatin44 50 61 1112.2HRAS, BRAF, PTEN
14aspartate449.2HRAS, BRAF, PTEN
15cyclic amp44 2410.1HRAS, BRAF, PTEN
16progesterone44 28 61 24 1113.1PTEN, BRAF, HRAS
17vegf449.1HRAS, BRAF, PTEN
18arginine449.1PTEN, BRAF, HRAS
19phosphatidylinositol449.1HRAS, BRAF, PTEN
20threonine449.0PTEN, BRAF, HRAS
21estrogen448.9HRAS, BRAF, PTEN
22retinoic acid44 249.9PTEN, BRAF, HRAS
23glucose448.9HRAS, BRAF, PTEN
24atp44 289.8HRAS, BRAF, PTEN
25agar448.7HRAS, NRAS, BRAF, PTEN
26inositol448.7MINPP1, PTEN
27oligonucleotide448.7PTEN, BRAF, NRAS, HRAS
28tyrosine448.6PTEN, BRAF, NRAS, HRAS

GO Terms for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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Biological processes related to Thyroid Carcinoma, Follicular, Somatic according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Rac protein signal transductionGO:0350229.8HRAS, NRAS
2regulation of synaptic transmission, GABAergicGO:0322289.8HRAS, NRAS
3striated muscle cell differentiationGO:0511469.8NRAS, HRAS
4regulation of long-term neuronal synaptic plasticityGO:0481699.8HRAS, NRAS
5visual learningGO:0085429.8NRAS, HRAS
6protein heterooligomerizationGO:0512919.7HRAS, BRAF
7MAPK cascadeGO:0001659.7HRAS, NRAS
8social behaviorGO:0351769.7HRAS, PTEN
9Ras protein signal transductionGO:0072659.7NRAS, HRAS
10organ morphogenesisGO:0098879.6HRAS, BRAF
11positive regulation of ERK1 and ERK2 cascadeGO:0703749.6HRAS, BRAF
12leukocyte migrationGO:0509009.5NRAS, HRAS
13insulin receptor signaling pathwayGO:0082869.5HRAS, NRAS
14GTP catabolic processGO:0061849.4HRAS, NRAS
15activation of MAPKK activityGO:0001869.3HRAS, NRAS, BRAF
16negative regulation of neuron apoptotic processGO:0435249.3BRAF, NRAS, HRAS
17inositol phosphate metabolic processGO:0436479.3MINPP1, PTEN
18small GTPase mediated signal transductionGO:0072649.3BRAF, NRAS, HRAS
19Fc-epsilon receptor signaling pathwayGO:0380959.2HRAS, NRAS, PTEN
20actin cytoskeleton organizationGO:0300369.2HRAS, NRAS
21epidermal growth factor receptor signaling pathwayGO:0071739.2HRAS, NRAS, PTEN
22positive regulation of cell proliferationGO:0082849.1HRAS, NRAS, PTEN
23innate immune responseGO:0450879.0HRAS, NRAS, PTEN
24fibroblast growth factor receptor signaling pathwayGO:0085438.7HRAS, NRAS, BRAF, PTEN
25neurotrophin TRK receptor signaling pathwayGO:0480118.7PTEN, BRAF, NRAS, HRAS

Products for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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Sources for Thyroid Carcinoma, Follicular, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet