MCID: THY059
MIFTS: 22

Thyroid Carcinoma, Follicular, Somatic malady

Cancer category

Summaries for Thyroid Carcinoma, Follicular, Somatic

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47OMIM, 33MalaCards
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MalaCards: Thyroid Carcinoma, Follicular, Somatic is related to familial adenomatous polyposis and myelodysplastic syndromes. An important gene associated with Thyroid Carcinoma, Follicular, Somatic is HRAS (Harvey rat sarcoma viral oncogene homolog), and among its related pathways are Pathways in cancer and VEGF Signaling Pathway. The compounds crcs and lovastatin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and thyroid, and related mouse phenotypes are integument and tumorigenesis.

Description from OMIM:47 188470

Aliases & Classifications for Thyroid Carcinoma, Follicular, Somatic

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47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

thyroid carcinoma, follicular, somatic 47


Related Diseases for Thyroid Carcinoma, Follicular, Somatic

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Thyroid Carcinoma, Follicular, Somatic:



Diseases related to thyroid carcinoma, follicular, somatic

Clinical Features for Thyroid Carcinoma, Follicular, Somatic

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47OMIM
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Clinical features from OMIM:

188470

Clinical synopsis from OMIM:

188470

Drugs & Therapeutics for Thyroid Carcinoma, Follicular, Somatic

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Thyroid Carcinoma, Follicular, Somatic

Drug clinical trials:

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Search NIH Clinical Center for Thyroid Carcinoma, Follicular, Somatic

Search CenterWatch for Thyroid Carcinoma, Follicular, Somatic

Genetic Tests for Thyroid Carcinoma, Follicular, Somatic

Anatomical Context for Thyroid Carcinoma, Follicular, Somatic

Sources:
33MalaCards
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MalaCards organs/tissues related to Thyroid Carcinoma, Follicular, Somatic:

33
Lymph node, Lung, Thyroid

Animal Models for Thyroid Carcinoma, Follicular, Somatic or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Thyroid Carcinoma, Follicular, Somatic:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5PTEN, HRAS, NRAS
2MP:00020068.2PTEN, HRAS, NRAS

Publications for Thyroid Carcinoma, Follicular, Somatic

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51PubMed
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Articles related to Thyroid Carcinoma, Follicular, Somatic:

idTitleAuthorsYear
1
Two somatic TSH receptor mutations in a patient with toxic metastasising follicular thyroid carcinoma and non-functional lung metastases. (14713269)
2003
2
Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas. (11297621)
2001

Genetic Variations for Thyroid Carcinoma, Follicular, Somatic

Expression for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

Search GEO for disease gene expression data for Thyroid Carcinoma, Follicular, Somatic.

Pathways for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

Sources:
30KEGG, 50PharmGKB, 56SinoBiological, 60Tocris Bioscience, 54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Thyroid Carcinoma, Follicular, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0NRAS
2
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9.3NRAS, HRAS
3
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9.3NRAS, HRAS
4
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9.3NRAS, HRAS
5
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9.3NRAS, HRAS
6
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9.3NRAS, HRAS
79.3NRAS, HRAS
8
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9.3NRAS, HRAS
9
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9.3NRAS, HRAS
10
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9.3NRAS, HRAS
119.3HRAS, NRAS
129.3HRAS, NRAS
139.3HRAS, NRAS
149.3HRAS, NRAS
159.3HRAS, NRAS
169.3HRAS, NRAS
17
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9.3HRAS, NRAS
18
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9.3HRAS, NRAS
19
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9.3HRAS, NRAS
20
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9.3HRAS, NRAS
219.3HRAS, NRAS
22
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9.0PTEN, HRAS
239.0PTEN, HRAS
24
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9.0HRAS, PTEN
25
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8.5NRAS, HRAS, PTEN
26
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8.5NRAS, HRAS, PTEN
27
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8.5NRAS, HRAS, PTEN
288.5PTEN, NRAS, HRAS
29
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8.5PTEN, HRAS, NRAS
30
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8.5PTEN, HRAS, NRAS
31
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8.5PTEN, NRAS, HRAS
32
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8.5PTEN, NRAS, HRAS
33
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8.5NRAS, PTEN, HRAS
34
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8.5NRAS, PTEN, HRAS
35
Development Endothelin-1/EDNRA signaling
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8.5PTEN, HRAS, NRAS
36
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8.5NRAS, PTEN, HRAS
37
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8.5NRAS, PTEN, HRAS
388.5NRAS, PTEN, HRAS
39
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8.5PTEN, NRAS, HRAS
40
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8.5HRAS, PTEN, NRAS
41
Translation Insulin regulation of translation
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8.5NRAS, PTEN, HRAS
42
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8.5HRAS, PTEN, NRAS
43
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8.5PTEN, NRAS, HRAS
448.5PTEN, HRAS, NRAS
458.5PTEN, NRAS, HRAS
46
Hide members
8.5PTEN, HRAS, NRAS
478.5PTEN, HRAS, NRAS
48
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8.5HRAS, NRAS, PTEN
49
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8.5HRAS, NRAS, PTEN
50
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8.5HRAS, NRAS, PTEN

Compounds for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank
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Compounds related to Thyroid Carcinoma, Follicular, Somatic according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1crcs459.0PTEN, HRAS
2lovastatin45 50 60 29 1113.0PTEN, HRAS
3gemcitabine45 50 1110.7PTEN, HRAS
4agar458.6PTEN, HRAS, NRAS
5oligonucleotide458.4NRAS, HRAS, PTEN

GO Terms for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

Sources:
16Gene Ontology
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Biological processes related to Thyroid Carcinoma, Follicular, Somatic according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Rac protein signal transductionGO:0350229.7HRAS, NRAS
2regulation of synaptic transmission, GABAergicGO:0322289.6NRAS, HRAS
3striated muscle cell differentiationGO:0511469.6HRAS, NRAS
4regulation of long-term neuronal synaptic plasticityGO:0481699.6HRAS, NRAS
5visual learningGO:0085429.5HRAS, NRAS
6activation of MAPKK activityGO:0001869.5NRAS, HRAS
7MAPK cascadeGO:0001659.4NRAS, HRAS
8Ras protein signal transductionGO:0072659.4HRAS, NRAS
9negative regulation of neuron apoptotic processGO:0435249.3HRAS, NRAS
10insulin receptor signaling pathwayGO:0082869.3HRAS, NRAS
11social behaviorGO:0351769.3PTEN, HRAS
12leukocyte migrationGO:0509009.2NRAS, HRAS
13actin cytoskeleton organizationGO:0300369.0HRAS, NRAS
14fibroblast growth factor receptor signaling pathwayGO:0085438.8PTEN, HRAS, NRAS
15Fc-epsilon receptor signaling pathwayGO:0380958.8PTEN, HRAS, NRAS
16epidermal growth factor receptor signaling pathwayGO:0071738.8NRAS, HRAS, PTEN
17neurotrophin TRK receptor signaling pathwayGO:0480118.8PTEN, HRAS, NRAS
18positive regulation of cell proliferationGO:0082848.7NRAS, HRAS, PTEN
19innate immune responseGO:0450878.7PTEN, HRAS, NRAS

Products for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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Sources for Thyroid Carcinoma, Follicular, Somatic

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet