MCID: THY059
MIFTS: 28

Thyroid Carcinoma, Follicular, Somatic malady

Cancer diseases category

Summaries for Thyroid Carcinoma, Follicular, Somatic

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46OMIM, 32MalaCards
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MalaCards: Thyroid Carcinoma, Follicular, Somatic is related to familial adenomatous polyposis and myelodysplastic syndromes. An important gene associated with Thyroid Carcinoma, Follicular, Somatic is HRAS (Harvey rat sarcoma viral oncogene homolog), and among its related pathways are Pathways in cancer and VEGF Signaling Pathway. The compounds crcs and lovastatin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and lymph node, and related mouse phenotypes are integument and tumorigenesis.

Description from OMIM:46 188470

Aliases & Classifications for Thyroid Carcinoma, Follicular, Somatic

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46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

thyroid carcinoma, follicular, somatic 46


Related Diseases for Thyroid Carcinoma, Follicular, Somatic

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Thyroid Carcinoma, Follicular, Somatic:



Diseases related to thyroid carcinoma, follicular, somatic

Clinical Features for Thyroid Carcinoma, Follicular, Somatic

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46OMIM
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Clinical features from OMIM:

188470

Clinical synopsis from OMIM:

188470

Drugs & Therapeutics for Thyroid Carcinoma, Follicular, Somatic

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Thyroid Carcinoma, Follicular, Somatic

Drug clinical trials:

Search ClinicalTrials for Thyroid Carcinoma, Follicular, Somatic

Search NIH Clinical Center for Thyroid Carcinoma, Follicular, Somatic

Search CenterWatch for Thyroid Carcinoma, Follicular, Somatic

Genetic Tests for Thyroid Carcinoma, Follicular, Somatic

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Anatomical Context for Thyroid Carcinoma, Follicular, Somatic

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32MalaCards
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MalaCards organs/tissues related to Thyroid Carcinoma, Follicular, Somatic:

32
Thyroid, Bone, Lymph node, Lung

Animal Models for Thyroid Carcinoma, Follicular, Somatic or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thyroid Carcinoma, Follicular, Somatic:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5PTEN, HRAS, NRAS
2MP:00020068.2PTEN, HRAS, NRAS

Publications for Thyroid Carcinoma, Follicular, Somatic

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Genetic Variations for Thyroid Carcinoma, Follicular, Somatic

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Expression for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

Search GEO for disease gene expression data for Thyroid Carcinoma, Follicular, Somatic.

Pathways for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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Sources:
29KEGG, 49PharmGKB, 55SinoBiological, 59Tocris Bioscience, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Thyroid Carcinoma, Follicular, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0NRAS
2
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9.3NRAS, HRAS
3
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9.3NRAS, HRAS
4
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9.3NRAS, HRAS
5
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9.3NRAS, HRAS
6
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9.3NRAS, HRAS
79.3NRAS, HRAS
8
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9.3NRAS, HRAS
9
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9.3NRAS, HRAS
10
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9.3NRAS, HRAS
119.3HRAS, NRAS
129.3HRAS, NRAS
139.3HRAS, NRAS
149.3HRAS, NRAS
159.3HRAS, NRAS
169.3HRAS, NRAS
17
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9.3HRAS, NRAS
18
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9.3HRAS, NRAS
19
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9.3HRAS, NRAS
20
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9.3HRAS, NRAS
219.3HRAS, NRAS
22
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9.0PTEN, HRAS
239.0PTEN, HRAS
24
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9.0HRAS, PTEN
25
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8.5NRAS, HRAS, PTEN
26
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8.5NRAS, HRAS, PTEN
27
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8.5NRAS, HRAS, PTEN
288.5PTEN, NRAS, HRAS
29
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8.5PTEN, HRAS, NRAS
30
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8.5PTEN, HRAS, NRAS
31
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8.5PTEN, NRAS, HRAS
32
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8.5PTEN, NRAS, HRAS
33
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8.5NRAS, PTEN, HRAS
34
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8.5NRAS, PTEN, HRAS
35
Development Endothelin-1/EDNRA signaling
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8.5PTEN, HRAS, NRAS
36
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8.5NRAS, PTEN, HRAS
37
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8.5NRAS, PTEN, HRAS
388.5NRAS, PTEN, HRAS
39
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8.5PTEN, NRAS, HRAS
40
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8.5HRAS, PTEN, NRAS
41
Translation Insulin regulation of translation
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8.5NRAS, PTEN, HRAS
42
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8.5HRAS, PTEN, NRAS
43
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8.5PTEN, NRAS, HRAS
448.5PTEN, HRAS, NRAS
458.5PTEN, NRAS, HRAS
46
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8.5PTEN, HRAS, NRAS
478.5PTEN, HRAS, NRAS
48
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8.5HRAS, NRAS, PTEN
49
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8.5HRAS, NRAS, PTEN
50
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8.5HRAS, NRAS, PTEN

Compounds for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank
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Compounds related to Thyroid Carcinoma, Follicular, Somatic according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1crcs449.0PTEN, HRAS
2lovastatin44 49 59 28 1113.0PTEN, HRAS
3gemcitabine44 49 1110.7PTEN, HRAS
4agar448.6PTEN, HRAS, NRAS
5oligonucleotide448.4PTEN, NRAS, HRAS

GO Terms for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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16Gene Ontology
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Biological processes related to Thyroid Carcinoma, Follicular, Somatic according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Rac protein signal transductionGO:0350229.7HRAS, NRAS
2regulation of synaptic transmission, GABAergicGO:0322289.6HRAS, NRAS
3striated muscle cell differentiationGO:0511469.6HRAS, NRAS
4regulation of long-term neuronal synaptic plasticityGO:0481699.6NRAS, HRAS
5visual learningGO:0085429.5NRAS, HRAS
6activation of MAPKK activityGO:0001869.5HRAS, NRAS
7MAPK cascadeGO:0001659.4HRAS, NRAS
8Ras protein signal transductionGO:0072659.4NRAS, HRAS
9negative regulation of neuron apoptotic processGO:0435249.3NRAS, HRAS
10insulin receptor signaling pathwayGO:0082869.3HRAS, NRAS
11social behaviorGO:0351769.3HRAS, PTEN
12leukocyte migrationGO:0509009.2NRAS, HRAS
13actin cytoskeleton organizationGO:0300369.0HRAS, NRAS
14fibroblast growth factor receptor signaling pathwayGO:0085438.8NRAS, HRAS, PTEN
15Fc-epsilon receptor signaling pathwayGO:0380958.8PTEN, HRAS, NRAS
16epidermal growth factor receptor signaling pathwayGO:0071738.8HRAS, NRAS, PTEN
17neurotrophin TRK receptor signaling pathwayGO:0480118.8HRAS, NRAS, PTEN
18positive regulation of cell proliferationGO:0082848.7HRAS, PTEN, NRAS
19innate immune responseGO:0450878.7NRAS, HRAS, PTEN

Products for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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  • Antibodies
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Sources for Thyroid Carcinoma, Follicular, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet