Thyroid Carcinoma, Follicular, Somatic malady

MalaCards: Thyroid Carcinoma, Follicular, Somatic, also known as thyroid carcinoma, is related to papillary thyroid carcinoma and goiter. An important gene associated with Thyroid Carcinoma, Follicular, Somatic is HRAS (v-Ha-ras Harvey rat sarcoma viral oncogene homolog), and among its related pathways are Transcription_Receptor-mediated HIF regulation and Transcription Receptor-mediated HIF regulation. The compounds crcs and gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include thyroid.

OMIM: 188470

thyroid carcinoma, follicular, somatic 33 thyroid carcinoma 43

Diseases related to thyroid carcinoma, follicular, somatic by text searches and GeneDecks gene sharing:

(show top 50)    (show all 99)

id	Related Disease	Score	Top Affiliating Genes
1	papillary thyroid carcinoma	38.4	PTEN, HRAS
2	goiter	31.1	HRAS, PTEN
3	familial adenomatous polyposis	30.6	PTEN, HRAS
4	follicular adenoma	30.1	PTEN, HRAS
5	thyroid adenoma	28.3	PTEN, HRAS
6	thyroid carcinoma	15.0
7	carcinoma	15.0
8	thyroiditis	15.0
9	brain cancer	12.5	HRAS, PTEN
10	juvenile myelomonocytic leukemia	12.5	HRAS, PTEN
11	pilocytic astrocytoma	12.5	PTEN, HRAS
12	nevus	12.4	HRAS, PTEN
13	gallbladder carcinoma	12.4	PTEN, HRAS
14	nonencapsulated sclerosing carcinoma	12.4	PTEN, HRAS
15	papilloma	12.4	PTEN, HRAS
16	neurofibromatosis	12.4	HRAS, PTEN
17	soft tissue sarcoma	12.4	HRAS, PTEN
18	squamous cell carcinoma of the head and neck	12.3	PTEN, HRAS
19	skin cancer	12.3	PTEN, HRAS
20	germ cell tumor	12.3	HRAS, PTEN
21	bladder carcinoma	12.2	PTEN, HRAS
22	rectal cloacogenic carcinoma	12.2	PTEN, HRAS
23	liver cancer	12.1	PTEN, HRAS
24	renal carcinoma	12.0	PTEN, HRAS
25	non-small cell lung carcinoma	11.8	HRAS, PTEN
26	familial medullary thyroid carcinoma	11.0
27	follicular thyroid carcinoma	10.7
28	multiple endocrine neoplasia	10.4
29	multiple endocrine neoplasia type 2a	9.5
30	adenoma	8.9
31	pheochromocytoma	8.7
32	hirschsprung's disease	8.6
33	cervicitis	8.2
34	polyposis	8.2
35	papillary carcinoma	8.2
36	thyroid cancer	7.8
37	cushing's syndrome	7.6
38	retinoblastoma	7.6
39	carcinoid tumors	7.3
40	familial papillary thyroid carcinoma	7.3
41	graves' disease	7.3
42	thyroid medullary carcinoma	7.3
43	thyroid carcinoma with thyrotoxicosis	7.3
44	thyroid cancer, anaplastic	7.3
45	thyroid cancer, follicular	7.3
46	thyroid cancer, medullary	7.3
47	thyroid carcinoma, papillary, with papillary renal neoplasia	6.9
48	thyroid carcinoma, nonmedullary, with cell oxyphilia	6.9
49	thyroid carcinoma, nonmedullary, 1	6.9
50	hurthle cell thyroid cancer	6.9

Clinical features from OMIM: 188470

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to thyroid carcinoma, follicular, somatic:

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Genes related to thyroid carcinoma, follicular, somatic according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.0
2	PTEN	phosphatase and tensin homolog	11.0

Pathways related to thyroid carcinoma, follicular, somatic according to GeneDecks:

(show all 31)

id	Pathway	Score	Top Affiliating Genes
1	Transcription_Receptor-mediated HIF regulation41	9.5	PTEN, HRAS
2	Transcription Receptor-mediated HIF regulation10	9.5	HRAS, PTEN
3	Endometrial cancer20	9.5	PTEN, HRAS
4	Signal transduction PTEN pathway10	9.5	PTEN, HRAS
5	Signal transduction_PTEN pathway41	9.5	PTEN, HRAS
6	IL-4 Pathway36	9.5	PTEN, HRAS
7	Glioma20	9.5	HRAS, PTEN
8	Development IGF-RI signaling10	9.5	HRAS, PTEN
9	Cytoskeleton remodeling_FAK signaling41	9.5	HRAS, PTEN
10	Cytoskeleton remodeling FAK signaling10	9.5	PTEN, HRAS
11	Development_IGF-1 receptor signaling41	9.5	PTEN, HRAS
12	Translation_Non-genomic (rapid) action of Androgen Receptor41	9.5	HRAS, PTEN
13	Melanoma20	9.5	HRAS, PTEN
14	Translation Non-genomic (rapid) action of Androgen Receptor10	9.5	HRAS, PTEN
15	IL-2 Pathway36	9.4	HRAS, PTEN
16	ErbB2-ErbB3 Heterodimers36	9.4	PTEN, HRAS
17	Immune response BCR pathway10	9.4	PTEN, HRAS
18	Immune response_BCR pathway41	9.4	PTEN, HRAS
19	Prostate cancer20	9.4	PTEN, HRAS
20	Glioblastoma Multiforme36	9.4	PTEN, HRAS
21	PI3K Signaling in B-Lymphocyte36	9.4	PTEN, HRAS
22	Tight junction20	9.4	PTEN, HRAS
23	IGF1R Signaling36	9.3	HRAS, PTEN
24	FAK1 Signaling36	9.3	HRAS, PTEN
25	Sertoli-Sertoli Cell Junction Dynamics36	9.3	PTEN, HRAS
26	Focal adhesion20	9.2	HRAS, PTEN
27	IP3 Pathway36	9.2	HRAS, PTEN
28	Epithelial Tight Junctions36	9.1	HRAS, PTEN
29	Pathways in cancer20	9.1	PTEN, HRAS
30	Epithelial Adherens Junctions36	9.0	PTEN, HRAS
31	PTEN Pathway36	8.8	PTEN, HRAS

Compounds related to thyroid carcinoma, follicular, somatic according to GeneDecks:

(show all 17)

id	Compound	Score	Top Affiliating Genes
1	crcs32	9.4	PTEN, HRAS
2	gemcitabine32 34 9 9	12.4	PTEN, HRAS
3	lovastatin32 42 9 9	12.4	PTEN, HRAS
4	agar32	9.4	PTEN, HRAS
5	phosphotyrosine32	9.4	HRAS, PTEN
6	methionine32	9.4	PTEN, HRAS
7	paclitaxel32 34 9 9	12.4	HRAS, PTEN
8	phospholipid32	9.4	HRAS, PTEN
9	rapamycin32 42	10.3	HRAS, PTEN
10	doxorubicin32 34 9 9	12.3	HRAS, PTEN
11	pd 98,05932	9.3	HRAS, PTEN
12	ly29400232	9.2	HRAS, PTEN
13	wortmannin32 42	10.2	HRAS, PTEN
14	estradiol32 9 18 9	12.1	PTEN, HRAS
15	genistein32 9 18 9	12.1	PTEN, HRAS
16	phosphoinositide32	9.0	HRAS, PTEN
17	paraffin32	8.8	HRAS, PTEN

Biological processes related to thyroid carcinoma, follicular, somatic according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	social behavior	GO:035176	9.3	PTEN, HRAS
2	fibroblast growth factor receptor signaling pathway	GO:008543	9.2	PTEN, HRAS
3	epidermal growth factor receptor signaling pathway	GO:007173	9.2	HRAS, PTEN
4	nerve growth factor receptor signaling pathway	GO:048011	9.1	HRAS, PTEN
5	positive regulation of cell proliferation	GO:008284	9.1	PTEN, HRAS
6	cell proliferation	GO:008283	9.0	PTEN, HRAS
7	negative regulation of cell proliferation	GO:008285	8.8	HRAS, PTEN