MCID: THY059
MIFTS: 31

Thyroid Carcinoma, Follicular, Somatic malady

Cancer diseases category

Summaries for Thyroid Carcinoma, Follicular, Somatic

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48OMIM, 34MalaCards
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MalaCards: Thyroid Carcinoma, Follicular, Somatic is related to follicular adenoma and papillary thyroid carcinoma. An important gene associated with Thyroid Carcinoma, Follicular, Somatic is HRAS (Harvey rat sarcoma viral oncogene homolog), and among its related pathways are PDGFR-beta signaling pathway and Kit Receptor Signaling Pathway. The compounds crcs and gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and lung, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Description from OMIM:48 188470

Aliases & Classifications for Thyroid Carcinoma, Follicular, Somatic

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48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

thyroid carcinoma, follicular, somatic 48


Related Diseases for Thyroid Carcinoma, Follicular, Somatic

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18GeneCards, 19GeneDecks
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Diseases related to Thyroid Carcinoma, Follicular, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1follicular adenoma10.0PTEN, HRAS
2papillary thyroid carcinoma10.0HRAS, PTEN
3thyroid cancer10.0HRAS, PTEN
4exanthem10.0NRAS, HRAS
5juvenile myelomonocytic leukemia10.0HRAS, NRAS
6astrocytoma10.0PTEN, HRAS
7gallbladder cancer10.0NRAS, HRAS
8noonan syndrome10.0NRAS, HRAS
9prostate cancer10.0PTEN, HRAS
10pancreatitis10.0HRAS, NRAS
11chronic myeloid leukemia10.0HRAS, NRAS
12sarcoma10.0NRAS, HRAS
13colorectal cancer10.0PTEN, HRAS
14endometrial carcinoma9.9HRAS, PTEN, NRAS
15lung cancer9.9PTEN, NRAS, HRAS
16ovarian cancer9.9PTEN, HRAS, NRAS
17melanoma9.9PTEN, HRAS, NRAS
18breast cancer9.9PTEN, NRAS, HRAS

Graphical network of diseases related to Thyroid Carcinoma, Follicular, Somatic:



Diseases related to thyroid carcinoma, follicular, somatic

Symptoms for Thyroid Carcinoma, Follicular, Somatic

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48OMIM
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Symptoms by clinical synopsis from OMIM:

188470

Clinical features from OMIM:

188470

Drugs & Therapeutics for Thyroid Carcinoma, Follicular, Somatic

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Thyroid Carcinoma, Follicular, Somatic

Drug clinical trials:

Search ClinicalTrials for Thyroid Carcinoma, Follicular, Somatic

Search NIH Clinical Center for Thyroid Carcinoma, Follicular, Somatic

Search CenterWatch for Thyroid Carcinoma, Follicular, Somatic

Genetic Tests for Thyroid Carcinoma, Follicular, Somatic

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Anatomical Context for Thyroid Carcinoma, Follicular, Somatic

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34MalaCards
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MalaCards organs/tissues related to Thyroid Carcinoma, Follicular, Somatic:

34
Thyroid, Bone, Lung, Lymph node

Animal Models for Thyroid Carcinoma, Follicular, Somatic or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Thyroid Carcinoma, Follicular, Somatic:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5HRAS, NRAS, PTEN
2MP:00053858.5HRAS, NRAS, PTEN
3MP:00107718.4HRAS, NRAS, PTEN
4MP:00028738.2PTEN, NRAS, HRAS

Publications for Thyroid Carcinoma, Follicular, Somatic

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Variations for Thyroid Carcinoma, Follicular, Somatic

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Sources:
1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Thyroid Carcinoma, Follicular, Somatic:

1
id Gene Name Type Significance SNP ID Assembly Location
1HRASNM_005343.2(HRAS): c.181C> A (p.Gln61Lys)single nucleotide variantPathogenicrs28933406GRCh37Chr 11, 533875: 533875
2NRASNM_002524.4(NRAS): c.182A> G (p.Gln61Arg)single nucleotide variantPathogenicrs11554290GRCh37Chr 1, 115256529: 115256529
3BRAFNM_004333.4(BRAF): c.1801A> G (p.Lys601Glu)single nucleotide variantPathogenicrs121913364GRCh37Chr 7, 140453134: 140453134
4MINPP1NM_004897.4(MINPP1): c.122C> T (p.Ser41Leu)single nucleotide variantPathogenicrs119486096GRCh37Chr 10, 89264794: 89264794
5MINPP1NM_004897.4(MINPP1): c.809A> G (p.Gln270Arg)single nucleotide variantPathogenicrs104894171GRCh37Chr 10, 89268264: 89268264

Expression for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

Search GEO for disease gene expression data for Thyroid Carcinoma, Follicular, Somatic.

Pathways for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 31KEGG, 56Reactome, 61Thomson Reuters, 52PharmGKB, 62Tocris Bioscience, 58SinoBiological, 55R&D Systems
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Pathways related to Thyroid Carcinoma, Follicular, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3PTEN, HRAS
2
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)39
9.3HRAS, PTEN
39.0HRAS, NRAS
49.0HRAS, NRAS
5
Show member pathways
9.0NRAS, HRAS
6
Show member pathways
9.0NRAS, HRAS
79.0HRAS, NRAS
8
Show member pathways
9.0HRAS, NRAS
99.0NRAS, HRAS
10
Show member pathways
9.0HRAS, NRAS
11
Show member pathways
9.0NRAS, HRAS
12
Show member pathways
9.0NRAS, HRAS
13
Show member pathways
9.0HRAS, NRAS
14
Show member pathways
9.0NRAS, HRAS
15
Show member pathways
9.0NRAS, HRAS
16
Show member pathways
9.0HRAS, NRAS
17
Show member pathways
9.0NRAS, HRAS
18
Show member pathways
9.0HRAS, NRAS
199.0NRAS, HRAS
209.0NRAS, HRAS
21
Show member pathways
EGFR-dependent Endothelin signaling events39
9.0HRAS, NRAS
22
Show member pathways
8.5PTEN, HRAS, NRAS
23
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
8.5PTEN, HRAS, NRAS
24
Show member pathways
8.5PTEN, HRAS, NRAS
25
Show member pathways
8.5PTEN, NRAS, HRAS
26
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.5NRAS, HRAS, PTEN
27
Show member pathways
8.5NRAS, HRAS, PTEN
28
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
8.5NRAS, HRAS, PTEN
29
Show member pathways
Signaling Pathways in Glioblastoma39
8.5HRAS, NRAS, PTEN
30
Show member pathways
Signal transduction PTEN pathway61
8.5HRAS, NRAS, PTEN
318.5PTEN, NRAS, HRAS
32
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
8.5HRAS, NRAS, PTEN
338.5PTEN, NRAS, HRAS
34
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.5NRAS, PTEN, HRAS
35
Show member pathways
8.5PTEN, NRAS, HRAS
36
Show member pathways
8.5PTEN, NRAS, HRAS
37
Show member pathways
8.5PTEN, NRAS, HRAS
388.5NRAS, HRAS, PTEN
39
Show member pathways
8.5NRAS, HRAS, PTEN
40
Show member pathways
8.5NRAS, HRAS, PTEN
418.5NRAS, PTEN, HRAS
42
Show member pathways
8.5PTEN, NRAS, HRAS
43
Show member pathways
8.5NRAS, PTEN, HRAS
448.5NRAS, HRAS, PTEN
45
Show member pathways
8.5NRAS, PTEN, HRAS
46
Show member pathways
8.5PTEN, NRAS, HRAS
47
Show member pathways
8.5NRAS, HRAS, PTEN
48
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
8.5NRAS, HRAS, PTEN
49
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
8.5HRAS, PTEN, NRAS
50
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
8.5HRAS, PTEN, NRAS

Compounds for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Thyroid Carcinoma, Follicular, Somatic according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1crcs469.6HRAS, PTEN
2gemcitabine46 52 1211.6PTEN, HRAS
3lovastatin46 52 62 30 1213.6HRAS, PTEN
4phosphotyrosine469.5PTEN, HRAS
5methionine469.5HRAS, PTEN
6paclitaxel46 52 1211.4HRAS, PTEN
7phospholipid469.4HRAS, PTEN
8rapamycin469.3PTEN, HRAS
9wortmannin469.3HRAS, PTEN
10pd 98,059469.2HRAS, PTEN
11ly294002469.0HRAS, PTEN
12agar468.8HRAS, NRAS, PTEN
13oligonucleotide468.8HRAS, NRAS, PTEN
14tyrosine468.7HRAS, NRAS, PTEN

GO Terms for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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17Gene Ontology
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Biological processes related to Thyroid Carcinoma, Follicular, Somatic according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1social behaviorGO:0351769.6HRAS, PTEN
2positive regulation of Rac protein signal transductionGO:0350229.4HRAS, NRAS
3regulation of synaptic transmission, GABAergicGO:0322289.4HRAS, NRAS
4striated muscle cell differentiationGO:0511469.3NRAS, HRAS
5regulation of long-term neuronal synaptic plasticityGO:0481699.3HRAS, NRAS
6visual learningGO:0085429.3NRAS, HRAS
7activation of MAPKK activityGO:0001869.3HRAS, NRAS
8MAPK cascadeGO:0001659.2NRAS, HRAS
9Ras protein signal transductionGO:0072659.2HRAS, NRAS
10leukocyte migrationGO:0509009.2HRAS, NRAS
11negative regulation of neuron apoptotic processGO:0435249.1NRAS, HRAS
12GTP catabolic processGO:0061849.1HRAS, NRAS
13actin cytoskeleton organizationGO:0300369.0HRAS, NRAS
14axon guidanceGO:0074119.0HRAS, NRAS
15insulin receptor signaling pathwayGO:0082868.9NRAS, HRAS
16fibroblast growth factor receptor signaling pathwayGO:0085438.9HRAS, NRAS, PTEN
17Fc-epsilon receptor signaling pathwayGO:0380958.8PTEN, NRAS, HRAS
18epidermal growth factor receptor signaling pathwayGO:0071738.8HRAS, NRAS, PTEN
19neurotrophin TRK receptor signaling pathwayGO:0480118.8HRAS, NRAS, PTEN
20positive regulation of cell proliferationGO:0082848.8PTEN, NRAS, HRAS
21innate immune responseGO:0450878.7HRAS, NRAS, PTEN
22small GTPase mediated signal transductionGO:0072648.7HRAS, NRAS

Products for genes affiliated with Thyroid Carcinoma, Follicular, Somatic

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Thyroid Carcinoma, Follicular, Somatic

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet